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1. Contact-force local impedance algorithm to guide effective pulmonary vein isolation in AF patients: 1-year outcome from an international multicenter clinical setting

Author

Solimene, Franscesco, Maggio, Ruggero, De Sanctis, Valerio, Escande, William, Malacrida, Maurizio, Stabile, Giuseppe, Zakine, Cyril, Champ-Rigot, Laure, Anselmino, Matteo, Ferraro, Anna, Mantica, Massimo, Zucchelli, Giulio, Dell’Era, Gabriele, Mascia, Giuseppe, Ricci Maga, Renata, Pandozi, Claudio, Rossi, Pietro, Scaglione, Marco, Zingarini, Gianluca, Garnier, Fabien, Loricchio, Maria Luisa, Pelargonio, Gemma, and Lepillier, Antoine

Published
2024
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2. Long-term clinical outcomes of patients with drug-induced type 1 Brugada electrocardiographic pattern: A nationwide cohort registry study

Author

Notarstefano, Pasquale, Adducci, Carmen, Franchetti, Livia Pardo, Berlier, Nicola, Sarubbi, Berardo, Sasso, Ferdinando Carlo, Golino, Paolo, Vicentini, Alessandro, Barca, Luca, Porto, Italo, Martini, Nicolò, Carrozzi, Chiara, Tola, Gianfranco, Floris, Roberto, Russo, Vincenzo, Caturano, Alfredo, Migliore, Federico, Guerra, Federico, Francia, Pietro, Nesti, Martina, Conte, Giulio, Perini, Alessandro Paoletti, Mascia, Giuseppe, Albani, Stefano, Marchese, Procolo, Santobuono, Vincenzo Ezio, Dendramis, Gregory, Rossi, Andrea, Attena, Emilio, Ghidini, Andrea Ottonelli, Sciarra, Luigi, Palamà, Zefferino, Baldi, Enrico, Romeo, Emanuele, D’Onofrio, Antonio, and Nigro, Gerardo

Published
2024
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3. Subcutaneous versus transvenous implantable cardioverter-defibrillator among drug-induced type-1 ECG pattern Brugada syndrome: a propensity score matching analysis from IBRYD study

Author

Russo, Vincenzo, Caturano, Alfredo, Guerra, Federico, Migliore, Federico, Mascia, Giuseppe, Rossi, Andrea, Nesti, Martina, Santobuono, Vincenzo Ezio, Attena, Emilio, Tola, Gianfranco, Sciarra, Luigi, Conte, Giulio, Paoletti Perini, Alessandro, Francia, Pietro, Dendramis, Gregory, Palamà, Zefferino, Albani, Stefano, Ottonelli Ghidini, Andrea, Calò, Leonardo, D’Onofrio, Antonio, and Baldi, Enrico

Published
2023
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4. Short- and Long-term Patient-Reported Outcomes of Subcutaneous Implantable Cardioverter-Defibrillator Therapy: Results from the RHYTHM DETECT Registry

Author

Bisignani, Antonio, primary, De Bonis, Silvana, additional, Palmisano, Pietro, additional, Bianchi, Valter, additional, Pecora, Domenico, additional, Tola, Gianfranco, additional, Nigro, Gerardo, additional, Caravati, Fabrizio, additional, Mascia, Giuseppe, additional, Rordorf, Roberto, additional, Notarstefano, Pasquale, additional, Polselli, Marco, additional, Bianchi, Stefano, additional, Lovecchio, Mariolina, additional, Valsecchi, Sergio, additional, and Droghetti, Andrea, additional

Published
2024
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7. Correction to: Subcutaneous versus transvenous implantable cardioverter-defibrillator among drug-induced type-1 ECG pattern Brugada syndrome: a propensity score matching analysis from IBRYD study

Author

Russo, Vincenzo, Caturano, Alfredo, Guerra, Federico, Migliore, Federico, Mascia, Giuseppe, Rossi, Andrea, Nesti, Martina, Santobuono, Vincenzo Ezio, Attena, Emilio, Tola, Gianfranco, Sciarra, Luigi, Conte, Giulio, Paoletti Perini, Alessandro, Francia, Pietro, Dendramis, Gregory, Palamà, Zefferino, Albani, Stefano, Ottonelli Ghidini, Andrea, Calò, Leonardo, D’Onofrio, Antonio, and Baldi, Enrico

Published
2023
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9. Italian Cardiological Guidelines (COCIS) for Competitive Sport Eligibility in athletes with heart disease: update 2024.

Author

ZEPPILLI, Paolo, Biffi, Alessandro, Cammarano, Michela, Castelletti, Silvia, Cavarretta, Elena, Cecchi, Franco, Colivicchi, Furio, Contursi, Maurizio, Corrado, Domenico, D'andrea, Antonello, Deferrari, Francesco, Delise, Pietro, Russo, Antonio Dello, Gabrielli, Domenico, Giada, Franco, Indolfi, Ciro, Maestrini, Viviana, Mascia, Giuseppe, MOS, Lucio, and Oliva, Fabrizio

Published
2024
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10. The RV1-V3 transition ratio: A novel electrocardiographic criterion for the differentiation of right versus left outflow tract premature ventricular complexes

Author

Efremidis, Michael, Vlachos, Konstantinos, Kyriakopoulou, Maria, Mililis, Panagiotis, Martin, Claire A., Bazoukis, George, Dragasis, Stylianos, Megarisiotou, Athanasia, Unger, Philippe, Frontera, Antonio, Mascia, Giuseppe, Saplaouras, Athanasios, Xydonas, Sotirios, Valkanas, Kosmas, Sacher, Frédéric, Jaïs, Pierre, and Letsas, Konstantinos P.

Published
2021
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11. Provisional Circulatory Support with Extracorporeal Membrane Oxygenation during Ventricular Tachycardia Ablation in Intermediate Risk Patients: A Case Series.

Author

Mascia, Giuseppe, Barca, Luca, Sartori, Paolo, Bianco, Daniele, Della Bona, Roberta, Di Donna, Paolo, and Porto, Italo

Subjects
*EXTRACORPOREAL membrane oxygenation, *VENTRICULAR arrhythmia, *VENTRICULAR tachycardia, *CATHETER ablation, *CARDIOGENIC shock, *ARTERIAL catheterization
Abstract

Background: Cardiogenic shock with acute hemodynamic decompensation may be one of the most serious risks in patients affected by ventricular tachycardia (VT). Its proper identification may have important implications in terms of pharmacological management, as might procedural planning in case of patients undergoing catheter ablation. Methods: We describe a case series of patients with provisional strategies for circulatory support in VT ablation, including the use of venoarterial extracorporeal membrane oxygenation (VA-ECMO) and vascular accesses in the electrophysiology lab but no initial ECMO activation due to an estimated intermediate pre-procedural risk from the case-series population. Results: In total, 10 patients (mean age 70 ± 11 years old, 9 males) with severe cardiomyopathy were admitted for incessant ventricular arrhythmia episodes, further diagnosis, and therapy planning; 1/10 patients (10%), documenting a PAINESD score of 14, underwent VA-ECMO cannulation due to electromechanical dissociation. All 10 patients were discharged alive. Conclusions: A pre-defined strategy before VT ablation is crucial. In our case series, the use of provisional circulatory support with VA-ECMO during incessant ablation of ventricular arrhythmia was a safe and winning alternative to upfront strategies. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Aspirin in Primary Prevention: Looking for Those Who Enjoy It.

Author

Della Bona, Roberta, Giubilato, Simona, Palmieri, Marco, Benenati, Stefano, Rossini, Roberta, Di Fusco, Stefania Angela, Novarese, Filippo, Mascia, Giuseppe, Gasparetto, Nicola, Di Monaco, Antonio, Gatto, Laura, Zilio, Filippo, Sorini Dini, Carlotta, Borrello, Francesco, Geraci, Giovanna, Riccio, Carmine, De Luca, Leonardo, Colivicchi, Furio, Grimaldi, Massimo, and Giulizia, Michele Massimo

Subjects
ANTILIPEMIC agents, ASPIRIN, CANCER prevention, CARDIOVASCULAR diseases risk factors, DISEASE risk factors
Abstract

Based on a wealth of evidence, aspirin is one of the cornerstones of secondary prevention of cardiovascular disease. However, despite several studies showing efficacy also in primary prevention, an unopposed excess risk of bleeding leading to a very thin safety margin is evident in subjects without a clear acute cardiovascular event. Overall, the variability in recommendations from different scientific societies for aspirin use in primary prevention is a classic example of failure of simple risk stratification models based on competing risks (atherothrombosis vs. bleeding), perceived to be opposed but intertwined at the pathophysiological level. Notably, cardiovascular risk is dynamic in nature and cannot be accurately captured by scores, which do not always consider risk enhancers. Furthermore, the widespread use of other potent medications in primary prevention, such as lipid-lowering and anti-hypertensive drugs, might be reducing the benefit of aspirin in recent trials. Some authors, drawing from specific pathophysiological data, have suggested that specific subgroups might benefit more from aspirin. This includes patients with diabetes and those with obesity; sex-based differences are considered as well. Moreover, molecular analysis of platelet reactivity has been proposed. A beneficial effect of aspirin has also been demonstrated for the prevention of cancer, especially colorectal. This review explores evidence and controversies concerning the use of aspirin in primary prevention, considering new perspectives in order to provide a comprehensive individualized approach. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Long-term clinical outcomes of patients with drug-induced type 1 Brugada electrocardiographic pattern: A nationwide cohort registry study

Author

Russo, Vincenzo, primary, Caturano, Alfredo, additional, Migliore, Federico, additional, Guerra, Federico, additional, Francia, Pietro, additional, Nesti, Martina, additional, Conte, Giulio, additional, Perini, Alessandro Paoletti, additional, Mascia, Giuseppe, additional, Albani, Stefano, additional, Marchese, Procolo, additional, Santobuono, Vincenzo Ezio, additional, Dendramis, Gregory, additional, Rossi, Andrea, additional, Attena, Emilio, additional, Ghidini, Andrea Ottonelli, additional, Sciarra, Luigi, additional, Palamà, Zefferino, additional, Baldi, Enrico, additional, Romeo, Emanuele, additional, D’Onofrio, Antonio, additional, Nigro, Gerardo, additional, Notarstefano, Pasquale, additional, Adducci, Carmen, additional, Franchetti, Livia Pardo, additional, Berlier, Nicola, additional, Sarubbi, Berardo, additional, Sasso, Ferdinando Carlo, additional, Golino, Paolo, additional, Vicentini, Alessandro, additional, Barca, Luca, additional, Porto, Italo, additional, Martini, Nicolò, additional, Carrozzi, Chiara, additional, Tola, Gianfranco, additional, and Floris, Roberto, additional

Published
2024
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17. The influence of age on the psychological profile of patients with cardiac implantable electronic devices: results from the Italian population in a multicenter study conducted by the European Heart Rhythm Association

Author

Fumagalli, Stefano, Pieragnoli, Paolo, Haugaa, Kristina H., Potpara, Tatjana S., Rasero, Laura, Ramacciati, Nicola, Ricciardi, Giuseppe, Solimene, Francesco, Mascia, Giuseppe, Mascioli, Giosuè, Zuo, Giulia, Roberts, Anna T., Marchionni, Niccolò, Lenarczyk, Radoslaw, Boveda, Serge, and Dagres, Nikolaos

Published
2019
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19. Insight into contact force local impedance technology for predicting effective pulmonary vein isolation

Author

Lepillier, Antoine, primary, Maggio, Ruggero, additional, De Sanctis, Valerio, additional, Malacrida, Maurizio, additional, Stabile, Giuseppe, additional, Zakine, Cyril, additional, Champ-Rigot, Laure, additional, Anselmino, Matteo, additional, Segreti, Luca, additional, Dell’Era, Gabriele, additional, Garnier, Fabien, additional, Mascia, Giuseppe, additional, Pandozi, Claudio, additional, Dello Russo, Antonio, additional, Scaglione, Marco, additional, Cosaro, Giuseppe, additional, Ferraro, Anna, additional, Paziaud, Olivier, additional, Maglia, Giampiero, additional, and Solimene, Francesco, additional

Published
2023
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22. PO-02-070 COMBINED LOCAL IMPEDANCE AND CONTACT FORCE FOR SUCCESSFUL RADIOFREQUENCY ABLATION OF ATRIAL FIBRILLATION

Author

Stabile, Giuseppe, primary, Lepillier, Antoine, additional, Anselmino, Matteo, additional, Maggio, Ruggero, additional, DeSanctis, Valerio, additional, ZAKINE, Cyril, additional, RIGOT, Laure CHAMP, additional, Dell'Era, Gabriele, additional, Garnier, Fabien, additional, Mascia, Giuseppe, additional, Segreti, Luca, additional, Escande, William, additional, Cosaro, Giuseppe, additional, Malacrida, Maurizio, additional, Maglia, Giampiero, additional, and Solimene, Francesco, additional

Published
2023
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24. Corrigendum to “Syncope in hypertrophic cardiomyopathy (part I): An updated systematic review and meta-analysis” [International Journal of Cardiology Volume 357, 15 June 2022, Pages 88–94].

Author

Mascia, Giuseppe, primary, Crotti, Lia, additional, Groppelli, Antonella, additional, Canepa, Marco, additional, Merlo, Andrea Carlo, additional, Benenati, Stefano, additional, Di Donna, Paolo, additional, Bona, Roberta Della, additional, Soranna, Davide, additional, Zambon, Antonella, additional, Porto, Italo, additional, Olivotto, Iacopo, additional, Parati, Gianfranco, additional, Brignole, Michele, additional, and Cecchi, Franco, additional

Published
2023
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25. Subcutaneous versus transvenous implantable cardioverter-defibrillator among drug-induced type-1 ECG pattern Brugada syndrome: a propensity score matching analysis from IBRYD study

Author

IBRYD Study Group, Russo, Vincenzo, Caturano, Alfredo, Guerra, Federico, Migliore, Federico, Mascia, Giuseppe, Rossi, Andrea, Nesti, Martina, Santobuono, Vincenzo Ezio, Attena, Emilio, Tola, Gianfranco, Sciarra, Luigi, Conte, Giulio, Paoletti Perini, Alessandro, Francia, Pietro, Dendramis, Gregory, Palamà, Zefferino, Albani, Stefano, Ottonelli Ghidini, Andrea, Calo, Leonardo, D'Onofrio, Antonio, Baldi, Enrico, Clinical sciences, Russo, Vincenzo, Caturano, Alfredo, Guerra, Federico, Migliore, Federico, Mascia, Giuseppe, Rossi, Andrea, Nesti, Martina, Santobuono, Vincenzo Ezio, Attena, Emilio, Tola, Gianfranco, Sciarra, Luigi, Conte, Giulio, Paoletti Perini, Alessandro, Francia, Pietro, Dendramis, Gregory, Palamà, Zefferino, Albani, Stefano, Ottonelli Ghidini, Andrea, Calò, Leonardo, D'Onofrio, Antonio, and Baldi, Enrico

Subjects
surgery, Sudden cardiac death, Drug-induced type 1 Brugada syndrome, Subcutaneous cardioverter-defibrillator, Brugada syndrome, ICD-related complication, ICD-related infection, Implantable cardioverter-defibrillator, Inappropriate shock, Transvenous cardioverter-defibrillator, Cardiology and Cardiovascular Medicine
Abstract

No real-world data are available about the complications rate in drug-induced type 1 Brugada Syndrome (BrS) patients with an implantable cardioverter-defibrillator (ICD). Aim of our study is to compare the device-related complications, infections, and inappropriate therapies among drug-induced type 1 BrS patients with transvenous- ICD (TV-ICD) versus subcutaneous-ICD (S-ICD). Data for this study were sourced from the IBRYD (Italian BRugada sYnDrome) registry which includes 619 drug-induced type-1 BrS patients followed at 20 Italian tertiary referral hospitals. For the present analysis, we selected 258 consecutive BrS patients implanted with ICD. 198 patients (76.7%) received a TV-ICD, while 60 a S-ICD (23.4%). And were followed-up for a median time of 84.3 [46.5–147] months. ICD inappropriate therapies were experienced by 16 patients (6.2%). 14 patients (7.1%) in the TVICD group and 2 patients (3.3%) in S-ICD group (log-rank P = 0.64). ICD-related complications occurred in 31 patients (12%); 29 (14.6%) in TV-ICD group and 2 (3.3%) in S-ICD group (log-rank P = 0.41). ICD-related infections occurred in 10 patients (3.88%); 9 (4.5%) in TV-ICD group and 1 (1.8%) in S-ICD group (log-rank P = 0.80). After balancing for potential confounders using the propensity score matching technique, no differences were found in terms of clinical outcomes between the two groups. In a real-world setting of drug-induced type-1 BrS patients with ICD, no significant differences in inappropriate ICD therapies, device-related complications, and infections were shown among S-ICD vs TV-ICD. However, a reduction in lead-related complications was observed in the S-ICD group. In conclusion, our evidence suggests that S-ICD is at least non-inferior to TV-ICD in this population and may also reduce the risk of lead-related complications which can expose the patients to the necessity of lead extractions.

Published
2022

27. Long-Term Outcomes of Transvenous Lead Extraction: A Comparison in Patients with or without Infection from the Italian Region with the Oldest Population.

Author

Barca, Luca, Mascia, Giuseppe, Di Donna, Paolo, Sartori, Paolo, Bianco, Daniele, Della Bona, Roberta, Benenati, Stefano, Merlo, Andrea Carlo, Buongiorno, Antonia Luisa, Kaufman, Niki, Vena, Antonio, Bassetti, Matteo, and Porto, Italo

Subjects
*OLDER people, *ATRIAL fibrillation, *OLDER patients, *ARTIFICIAL implants, *ELECTRONIC equipment
Abstract

Background: The gold standard for the treatment of cardiac implantable electronic devices (CIEDs)-related infection and lead malfunction is transvenous lead extraction (TLE). To date, the risk of mortality directly related to TLE procedures is relatively low, but data on post-procedural and long-term mortality are limited, even more in the aging population. Methods: Consecutive patients with CIEDs who underwent TLE were retrospectively studied. The primary outcome was the endpoint of death, considering independent predictors of long-term clinical outcomes in the TLE aging population comparing patients with and without infection. Results: One hundred nineteen patients (male 77%; median age 76 years) were included in the analysis. Eighty-two patients (69%) documented infection, and thirty-seven (31%) were extracted for a different reason. Infected patients were older (80 vs. 68 years, p-value > 0.001) with more implanted catheters (p-value < 0.001). At the last follow-up (FU) available (median FU 4.1 years), mortality reached 37% of the patient population, showing a statistically significant difference between infected versus non-infected groups. At univariable analysis, age at TLE, atrial fibrillation, and anemia remained significant correlates of mortality; at multivariable analysis, only patients with anemia and atrial fibrillation have a 2.3-fold (HR 2.34; CI 1.16–4.75) and a 2.5-fold (HR 2.46; CI 1.33–4.54) increased rate of death, respectively. Conclusion: Our long-term data showed that aging patients who underwent TLE for CIED-related infection exhibit a high mortality risk during a long-term follow-up, potentially leading to a rapid and effective procedural approach in this patient population. [ABSTRACT FROM AUTHOR]

Published
2023
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29. Erratum: AV junction ablation and cardiac resynchronization for patients with permanent atrial fibrillation and narrow QRS: The APAF-CRT mortality trial (European Heart Journal (2021) DOI: 10.1093/eurheartj/ehab569)

Author

Brignole, Michele, Pentimalli, Francesco, Palmisano, Pietro, Landolina, Maurizio, Quartieri, Fabio, Occhetta, Eraldo, Calò, Leonardo, Mascia, Giuseppe, Mont, Lluis, Vernooy, Kevin, van Dijk, Vincent, Allaart, Cor, Fauchier, Laurent, Gasparini, Maurizio, Parati, Gianfranco, Soranna, Davide, Rienstra, Michiel, van Gelder, Isabelle C., Cardiology, ACS - Heart failure & arrhythmias, ACS - Microcirculation, and AII - Infectious diseases

Abstract

In the originally published version of this manuscript, there were errors in the Table 2 data. In the "Drug (n = 70)" column, in row 5 it should read "8/26 (31%)" instead of "8/28 (29%)" and in row 6 it should read "12/44 (27%)" instead of "12/42 (29%)". These errors have now been corrected online.

Published
2022

30. Corrigendum to: AV junction ablation and cardiac resynchronization for patients with permanent atrial fibrillation and narrow QRS: the APAF-CRT mortality trial

Author

Brignole, Michele, primary, Pentimalli, Francesco, additional, Palmisano, Pietro, additional, Landolina, Maurizio, additional, Quartieri, Fabio, additional, Occhetta, Eraldo, additional, Calò, Leonardo, additional, Mascia, Giuseppe, additional, Mont, Lluis, additional, Vernooy, Kevin, additional, van Dijk, Vincent, additional, Allaart, Cor, additional, Fauchier, Laurent, additional, Gasparini, Maurizio, additional, Parati, Gianfranco, additional, Soranna, Davide, additional, Rienstra, Michiel, additional, and Van Gelder, Isabelle C, additional

Published
2021
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32. Is His‐optimized superior to conventional cardiac resynchronization therapy in improving heart failure? Results from a propensity‐matched study

Author

Senes, Jacopo, primary, Mascia, Giuseppe, additional, Bottoni, Nicola, additional, Oddone, Daniele, additional, Donateo, Paolo, additional, Grimaldi, Teresa, additional, Minneci, Calogero, additional, Bertolozzi, Iacopo, additional, Brignole, Michele, additional, Puggioni, Enrico, additional, and Coluccia, Giovanni, additional

Published
2021
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35. Brugada syndrome and syncope: a practical approach for diagnosis and treatment

Author

Mascia, G, Della Bona, R, Ameri, P, Canepa, M, Porto, I, Parati, G, Crotti, L, Brignole, M, Mascia, Giuseppe, Della Bona, Roberta, Ameri, Pietro, Canepa, Marco, Porto, Italo, Parati, Gianfranco, Crotti, Lia, Brignole, Michele, Mascia, G, Della Bona, R, Ameri, P, Canepa, M, Porto, I, Parati, G, Crotti, L, Brignole, M, Mascia, Giuseppe, Della Bona, Roberta, Ameri, Pietro, Canepa, Marco, Porto, Italo, Parati, Gianfranco, Crotti, Lia, and Brignole, Michele

Abstract

Syncope in patients with Brugada electrocardiogram pattern may represent a conundrum in the decision algorithm because incidental benign forms, especially neurally mediated syncope, are very frequent in this syndrome similarly to the general population. Arrhythmic syncope in Brugada syndrome typically results from a self-terminating sustained ventricular tachycardia or paroxysmal ventricular fibrillation, potentially leading to sudden cardiac death. Distinguishing syncope due to malignant arrhythmias from a benign form is often difficult unless an electrocardiogram is recorded during the episode. We performed a review of the existing literature and propose a practical approach for diagnosis and treatment of the patients with Brugada syndrome and syncope.

Published
2021

37. Interpretation of elevated high-sensitivity cardiac troponin I in elite soccer players previously infected by severe acute respiratory syndrome coronavirus 2

Author

Mascia, Giuseppe, primary, Pescetelli, Fabio, additional, Baldari, Amedeo, additional, Gatto, Piero, additional, Seitun, Sara, additional, Sartori, Paolo, additional, Pieroni, Maurizio, additional, Calò, Leonardo, additional, Della Bona, Roberta, additional, and Porto, Italo, additional

Published
2021
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45. Atrial fibrillation in Brugada syndrome: Current perspectives

Author

Vlachos, Konstantinos, primary, Mascia, Giuseppe, additional, Martin, Claire A., additional, Bazoukis, George, additional, Frontera, Antonio, additional, Cheniti, Ghassen, additional, Letsas, Konstantinos P., additional, Efremidis, Micheal, additional, Georgopoulos, Stamatis, additional, Gkalapis, Charis, additional, Duchateau, Josselin, additional, Parmbrun, Thomas, additional, Derval, Nicholas, additional, Hocini, Mélèze, additional, Haissaguerre, Michel, additional, Jais, Pierre, additional, and Sacher, Frédéric, additional

Published
2020
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47. AV junction ablation and cardiac resynchronization for patients with permanent atrial fibrillation and narrow QRS: the APAF-CRT mortality trial.

Author

Brignole, Michele, Pentimalli, Francesco, Palmisano, Pietro, Landolina, Maurizio, Quartieri, Fabio, Occhetta, Eraldo, Calò, Leonardo, Mascia, Giuseppe, Mont, Lluis, Vernooy, Kevin, Dijk, Vincent van, Allaart, Cor, Fauchier, Laurent, Gasparini, Maurizio, Parati, Gianfranco, Soranna, Davide, Rienstra, Michiel, Gelder, Isabelle C Van, and Investigators, for the APAF-CRT Trial

Subjects
ATRIAL fibrillation, HEART failure, CARDIAC pacing, CATHETER ablation, PATIENTS
Abstract

Aims  In patients with atrial fibrillation (AF) and heart failure (HF), strict and regular rate control with atrioventricular junction ablation and biventricular pacemaker (Ablation + CRT) has been shown to be superior to pharmacological rate control in reducing HF hospitalizations. However, whether it also improves survival is unknown. Methods and results  In this international, open-label, blinded outcome trial, we randomly assigned patients with severely symptomatic permanent AF >6 months, narrow QRS (≤110 ms) and at least one HF hospitalization in the previous year to Ablation + CRT or to pharmacological rate control. We hypothesized that Ablation + CRT is superior in reducing the primary endpoint of all-cause mortality. A total of 133 patients were randomized. The mean age was 73 ± 10 years, and 62 (47%) were females. The trial was stopped for efficacy at interim analysis after a median of 29 months of follow-up per patient. The primary endpoint occurred in 7 patients (11%) in the Ablation + CRT arm and in 20 patients (29%) in the Drug arm [hazard ratio (HR) 0.26, 95% confidence interval (CI) 0.10–0.65; P  = 0.004]. The estimated death rates at 2 years were 5% and 21%, respectively; at 4 years, 14% and 41%. The benefit of Ablation + CRT of all-cause mortality was similar in patients with ejection fraction (EF) ≤35% and in those with >35%. The secondary endpoint combining all-cause mortality or HF hospitalization was significantly lower in the Ablation + CRT arm [18 (29%) vs. 36 (51%); HR 0.40, 95% CI 0.22–0.73; P  = 0.002]. Conclusions  Ablation + CRT was superior to pharmacological therapy in reducing mortality in patients with permanent AF and narrow QRS who were hospitalized for HF, irrespective of their baseline EF. Study registration ClinicalTrials.gov Identifier: NCT02137187. [ABSTRACT FROM AUTHOR]

Published
2021
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49. The influence of age on the psychological profile of patients with cardiac implantable electronic devices: results from the Italian population in a multicenter study conducted by the European Heart Rhythm Association

Author

Fumagalli, Stefano, primary, Pieragnoli, Paolo, additional, Haugaa, Kristina H., additional, Potpara, Tatjana S., additional, Rasero, Laura, additional, Ramacciati, Nicola, additional, Ricciardi, Giuseppe, additional, Solimene, Francesco, additional, Mascia, Giuseppe, additional, Mascioli, Giosuè, additional, Zuo, Giulia, additional, Roberts, Anna T., additional, Marchionni, Niccolò, additional, Lenarczyk, Radoslaw, additional, Boveda, Serge, additional, and Dagres, Nikolaos, additional

Published
2018
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