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4. Clinical and immunologic responses in melanoma patients vaccinated with MAGE-A3-genetically modified lymphocytes

Author

Russo, Vincenzo, Pilla, Lorenzo, Lunghi, Francesca, Crocchiolo, Roberto, Greco, Raffaella, Ciceri, Fabio, Maggioni, Daniela, Fontana, Raffaella, Mukenge, Sylvain, Rivoltini, Licia, Rigamonti, Gianluigi, Mercuri, Santo Raffaele, Nicoletti, Roberto, Maschio, Alessandro Del, Gianolli, Luigi, Fazio, Ferruccio, Marchianò, Alfonso, Florio, Annabella Di, Maio, Michele, Salomoni, Monica, Gallo-Stampino, Corrado, Fiacco, Matteo Del, Lambiase, Antonio, Coulie, Pierre G., Patuzzo, Roberto, Parmiani, Giorgio, Traversari, Catia, Bordignon, Claudio, Santinami, Mario, and Bregni, Marco

Published
2013
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9. Energy metabolism in diabetic and nondiabetic heart transplant recipients. (Pathophysiology/Complications)

Author

Benedini, Stefano, Fiocchi, Roberto, Battezzati, Alberto, Scifo, Paola, Sereni, Lucia Piceni, Gamba, Amando, Mammana, Carmelo, Maschio, Alessandro Del, Perseghin, Gianluca, and Luzi, Livio

Subjects
Diabetes -- Physiological aspects -- Research, Heart -- Transplantation, Health, Physiological aspects
Abstract

OBJECTIVE -- This study examined the metabolic effects of heart transplantation in patients in end-stage cardiac failure. RESEARCH DESIGN AND METHODS -- A total of 18 patients after heart transplantation [...]

Published
2002

11. Additional file 4: Table S3. of Chromogranin-A production and fragmentation in patients with Takayasu arteritis

Author

Tombetti, Enrico, Colombo, Barbara, Chio, Maria Di, Sartorelli, Silvia, Papa, Maurizio, Annalaura Salerno, Bozzolo, Enrica, Tombolini, Elisabetta, Benedetti, Giulia, Godi, Claudia, Lanzani, Chiara, Rovere-Querini, Patrizia, Maschio, Alessandro Del, Ambrosi, Alessandro, Cobelli, Francesco De, Sabbadini, Maria, Baldissera, Elena, Corti, Angelo, and Manfredi, Angelo

Subjects
endocrine system
Abstract

CgA peptides in patients with TA stratified for therapy with steroids or immunosuppressive agents. (DOC 63 kb)

Published
2016
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12. Additional file 5: Table S2. of Chromogranin-A production and fragmentation in patients with Takayasu arteritis

Author

Tombetti, Enrico, Colombo, Barbara, Chio, Maria Di, Sartorelli, Silvia, Papa, Maurizio, Annalaura Salerno, Bozzolo, Enrica, Tombolini, Elisabetta, Benedetti, Giulia, Godi, Claudia, Lanzani, Chiara, Rovere-Querini, Patrizia, Maschio, Alessandro Del, Ambrosi, Alessandro, Cobelli, Francesco De, Sabbadini, Maria, Baldissera, Elena, Corti, Angelo, and Manfredi, Angelo

Subjects
endocrine system
Abstract

Four-way analysis of the variance (ANOVA) of the levels of CgA peptides and of the anti-angiogenic CgA potential. (DOC 44 kb)

Published
2016
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13. Additional file 2: Table S1. of Chromogranin-A production and fragmentation in patients with Takayasu arteritis

Author

Tombetti, Enrico, Colombo, Barbara, Chio, Maria Di, Sartorelli, Silvia, Papa, Maurizio, Annalaura Salerno, Bozzolo, Enrica, Tombolini, Elisabetta, Benedetti, Giulia, Godi, Claudia, Lanzani, Chiara, Rovere-Querini, Patrizia, Maschio, Alessandro Del, Ambrosi, Alessandro, Cobelli, Francesco De, Sabbadini, Maria, Baldissera, Elena, Corti, Angelo, and Manfredi, Angelo

Subjects
endocrine system
Abstract

CgA peptides in TA patients with and without arterial hypertension, stratified for therapy with PPIs. (DOC 49 kb)

Published
2016
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14. Early T1 Myocardial MRI Mapping: Value in Detecting Myocardial Hyperemia in Acute Myocarditis

Author

Palmisano, Anna, Benedetti, Giulia, Faletti, Riccardo, Rancoita, Paola M. V., Gatti, Marco, Peretto, Giovanni, Sala, Simone, Boccia, Edda, Francone, Marco, Galea, Nicola, Basso, Cristina, Maschio, Alessandro Del, Cobelli, Francesco De, and Esposito, Antonio

Abstract

Early myocardial T1 shortening can be used to quantify myocardial hyperemia in participants with acute myocarditis.

Published
2020
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16. Multicenter Surveillance of Women at High Genetic Breast Cancer Risk Using Mammography, Ultrasonography, and Contrast-Enhanced Magnetic Resonance Imaging (the High Breast Cancer Risk Italian 1 Study) Final Results

Author

Sardanelli F, Podo F, Santoro F, Manoukian S, Bergonzi S, Trecate G, Vergnaghi D, Federico M, Cortesi L, Corcione S, Morassut S, Di Maggio C, Cilotti A, Martincich L, Calabrese M, Zuiani C, Preda L, Bonanni B, Carbonaro LA, Contegiacomo A, Panizza P, Di Cesare E, Savarese A, Crecco M, Tonutti M, Belli P, Maschio A. Del, for the High Breast Cancer Risk Italian 1 Study, TURCHETTI, DANIELA, Sardanelli, F, Podo, F, Santoro, F, Manoukian, S, Bergonzi, S, Trecate, G, Vergnaghi, D, Federico, M, Cortesi, L, Corcione, S, Morassut, S, Di Maggio, C, Cilotti, A, Martincich, L, Calabrese, M, Zuiani, C, Preda, L, Bonanni, B, Carbonaro, La, Contegiacomo, A, Panizza, P, Di Cesare, E, Savarese, A, Crecco, M, Turchetti, D, Tonutti, M, Belli, P, DEL MASCHIO, Alessandro, Sardanelli F, Podo F, Santoro F, Manoukian S, Bergonzi S, Trecate G, Vergnaghi D, Federico M, Cortesi L, Corcione S, Morassut S, Di Maggio C, Cilotti A, Martincich L, Calabrese M, Zuiani C, Preda L, Bonanni B, Carbonaro LA, Contegiacomo A, Panizza P, Di Cesare E, Savarese A, Crecco M, Turchetti D, Tonutti M, Belli P, Maschio A Del, and for the High Breast Cancer Risk Italian 1 (HIBCRIT-1) Study

Subjects
Oncology, magnetic resonance imaging (MRI), breast neoplasms, BRCA1–2, high risk of breast cancer, Statistics as Topic, Contrast Media, Risk Factors, BRCA 1-2, Medicine, Prospective Studies, skin and connective tissue diseases, Contrast-enhanced Magnetic Resonance Imaging, Ultrasonography, medicine.diagnostic_test, BRCA1 Protein, ultrasonography, General Medicine, Middle Aged, Magnetic Resonance Imaging, Italy, Population Surveillance, Female, Radiology, medicine.symptom, MRI, Mammography, Adult, medicine.medical_specialty, mammography, Breast neoplasma, Breast Neoplasms, GENETIC RISK, Asymptomatic, Risk Assessment, Sensitivity and Specificity, Statistics, Nonparametric, Young Adult, Breast cancer, Genetic breast cancer, BREAST CANCER, Predictive Value of Tests, Internal medicine, Confidence Intervals, Humans, Radiology, Nuclear Medicine and imaging, Genetic Testing, Aged, Chi-Square Distribution, business.industry, BRCA mutation, Magnetic resonance imaging, BRCA1, medicine.disease, BRCA2, ROC Curve, business
Abstract

OBJECTIVES: : To prospectively compare clinical breast examination, mammography, ultrasonography, and contrast-enhanced magnetic resonance imaging (MRI) in a multicenter surveillance of high-risk women. MATERIALS AND METHODS: : We enrolled asymptomatic women aged ≥ 25: BRCA mutation carriers; first-degree relatives of BRCA mutation carriers, and women with strong family history of breast/ovarian cancer, including those with previous personal breast cancer. RESULTS: : A total of 18 centers enrolled 501 women and performed 1592 rounds (3.2 rounds/woman). Forty-nine screen-detected and 3 interval cancers were diagnosed: 44 invasive, 8 ductal carcinoma in situ; only 4 pT2 stage; 32 G3 grade. Of 39 patients explored for nodal status, 28 (72%) were negative. Incidence per year-woman resulted 3.3% overall, 2.1%

Published
2011

18. Apparent diffusion coefficient in the evaluation of side-specific extracapsular extension in prostate cancer: Development and external validation of a nomogram of clinical use

Author

Giganti, Francesco, primary, Coppola, Andrea, additional, Ambrosi, Alessandro, additional, Ravelli, Silvia, additional, Esposito, Antonio, additional, Freschi, Massimo, additional, Briganti, Alberto, additional, Scattoni, Vincenzo, additional, Salonia, Andrea, additional, Gallina, Andrea, additional, Dehò, Federico, additional, Cardone, Gianpiero, additional, Balconi, Giuseppe, additional, Gaboardi, Franco, additional, Montorsi, Francesco, additional, Maschio, Alessandro Del, additional, and De Cobelli, Francesco, additional

Published
2016
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19. Leukocytes recruited by tumor-derived HMGB1 sustain peritoneal carcinomatosis

Author

Cottone, Lucia, primary, Capobianco, Annalisa, additional, Gualteroni, Chiara, additional, Monno, Antonella, additional, Raccagni, Isabella, additional, Valtorta, Silvia, additional, Canu, Tamara, additional, Tomaso, Tiziano Di, additional, Lombardo, Angelo, additional, Esposito, Antonio, additional, Moresco, Rosa Maria, additional, Maschio, Alessandro Del, additional, Naldini, Luigi, additional, Rovere-Querini, Patrizia, additional, Bianchi, Marco E., additional, and Manfredi, Angelo A., additional

Published
2016
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20. Clinical and immunologic responses in melanoma patients vaccinated with MAGE-A3-genetically modified lymphocytes.

Author

UCL - SSS/DDUV - Institut de Duve, Russo, Vincenzo, Pilla, Lorenzo, Lunghi, Francesca, Crocchiolo, Roberto, Greco, Raffaella, Ciceri, Fabio, Maggioni, Daniela, Fontana, Raffaella, Mukenge, Sylvain, Rivoltini, Licia, Rigamonti, Gianluigi, Mercuri, Santo Raffaele, Nicoletti, Roberto, Maschio, Alessandro Del, Gianolli, Luigi, Fazio, Ferruccio, Marchianò, Alfonso, Florio, Annabella Di, Maio, Michele, Salomoni, Monica, Gallo-Stampino, Corrado, Fiacco, Matteo Del, Lambiase, Antonio, Coulie, Pierre, Patuzzo, Roberto, Parmiani, Giorgio, Traversari, Catia, Bordignon, Claudio, Santinami, Mario, Bregni, Marco, UCL - SSS/DDUV - Institut de Duve, Russo, Vincenzo, Pilla, Lorenzo, Lunghi, Francesca, Crocchiolo, Roberto, Greco, Raffaella, Ciceri, Fabio, Maggioni, Daniela, Fontana, Raffaella, Mukenge, Sylvain, Rivoltini, Licia, Rigamonti, Gianluigi, Mercuri, Santo Raffaele, Nicoletti, Roberto, Maschio, Alessandro Del, Gianolli, Luigi, Fazio, Ferruccio, Marchianò, Alfonso, Florio, Annabella Di, Maio, Michele, Salomoni, Monica, Gallo-Stampino, Corrado, Fiacco, Matteo Del, Lambiase, Antonio, Coulie, Pierre, Patuzzo, Roberto, Parmiani, Giorgio, Traversari, Catia, Bordignon, Claudio, Santinami, Mario, and Bregni, Marco

Abstract

Cancer vaccines have recently been shown to induce some clinical benefits. The relationship between clinical activity and anti-vaccine T cell responses is somewhat controversial. Indeed, in many trials it has been documented that the induction of vaccine-specific T cells exceeds the clinical responses observed. Here, we evaluate immunological and clinical responses in 23 MAGE-A3(+) melanoma patients treated with autologous lymphocytes genetically engineered to express the tumor antigen MAGE-A3 and the viral gene product thymidine kinase of the herpes simplex virus (HSV-TK). HSV-TK was used as safety system in case of adverse events and as tracer antigen to monitor the immune competence of treated patients. The increase of anti-TK and anti-MAGE-A3 T-cells after vaccination was observed in 90 and 27% of patients, respectively. Among 19 patients with measurable disease, we observed a disease control rate of 26.3%, with one objective clinical response, and four durable, stable diseases. Three patients out of five with no evidence of disease (NED) at the time of vaccination remained NED after 73+, 70+ and 50+ months. Notably, we report that only patients experiencing MAGE-A3-specific immune responses showed a clinical benefit. Additionally, we report that responder and non-responder patients activate and expand T cells against the tracer antigen TK in a similar way, suggesting that local rather than systemic immune suppression might be involved in limiting clinically relevant antitumor immune responses.

Published
2013

21. Magnetic Resonance Imaging at 7T Reveals Common Events in Age-Related Sarcopenia and in the Homeostatic Response to Muscle Sterile Injury

Author

Esposito, Antonio, primary, Campana, Lara, additional, Palmisano, Anna, additional, De Cobelli, Francesco, additional, Canu, Tamara, additional, Santarella, Francesco, additional, Colantoni, Caterina, additional, Monno, Antonella, additional, Vezzoli, Michela, additional, Pezzetti, Giulio, additional, Manfredi, Angelo A., additional, Rovere-Querini, Patrizia, additional, and Maschio, Alessandro Del, additional

Published
2013
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22. Clinical and immunologic responses in melanoma patients vaccinated with MAGE-A3-genetically modified lymphocytes

Author

Russo, Vincenzo, primary, Pilla, Lorenzo, additional, Lunghi, Francesca, additional, Crocchiolo, Roberto, additional, Greco, Raffaella, additional, Ciceri, Fabio, additional, Maggioni, Daniela, additional, Fontana, Raffaella, additional, Mukenge, Sylvain, additional, Rivoltini, Licia, additional, Rigamonti, Gianluigi, additional, Mercuri, Santo Raffaele, additional, Nicoletti, Roberto, additional, Maschio, Alessandro Del, additional, Gianolli, Luigi, additional, Fazio, Ferruccio, additional, Marchianò, Alfonso, additional, Florio, Annabella Di, additional, Maio, Michele, additional, Salomoni, Monica, additional, Gallo-Stampino, Corrado, additional, Fiacco, Matteo Del, additional, Lambiase, Antonio, additional, Coulie, Pierre G., additional, Patuzzo, Roberto, additional, Parmiani, Giorgio, additional, Traversari, Catia, additional, Bordignon, Claudio, additional, Santinami, Mario, additional, and Bregni, Marco, additional

Published
2012
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23. T Cell Suicide Gene Therapy Prompts Thymic Renewal in Adults After Haploidentical Hematopoietic Stem Cell Transplantation in the Absence of Post-Transplant Immunesuppression

Author

Vago, Luca, primary, Oliveira, Giacomo, additional, Bondanza, Attilio, additional, Noviello, Maddalena, additional, Soldati, Corrado, additional, Ghio, Domenico, additional, Brigida, Immacolata, additional, Greco, Raffaella, additional, Stanghellini, Maria Teresa Lupo, additional, Peccatori, Jacopo, additional, Fracchia, Sergio, additional, Fiacco, Matteo Del, additional, Traversari, Catia, additional, Aiuti, Alessandro, additional, Lambiase, Antonio, additional, Maschio, Alessandro Del, additional, Bordignon, Claudio, additional, Ciceri, Fabio, additional, and Bonini, Chiara, additional

Published
2011
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24. Multicenter Surveillance of Women at High Genetic Breast Cancer Risk Using Mammography, Ultrasonography, and Contrast-Enhanced Magnetic Resonance Imaging (the High Breast Cancer Risk Italian 1 Study)

Author

Sardanelli, Francesco, primary, Podo, Franca, additional, Santoro, Filippo, additional, Manoukian, Siranoush, additional, Bergonzi, Silvana, additional, Trecate, Giovanna, additional, Vergnaghi, Daniele, additional, Federico, Massimo, additional, Cortesi, Laura, additional, Corcione, Stefano, additional, Morassut, Sandro, additional, Di Maggio, Cosimo, additional, Cilotti, Anna, additional, Martincich, Laura, additional, Calabrese, Massimo, additional, Zuiani, Chiara, additional, Preda, Lorenzo, additional, Bonanni, Bernardo, additional, Carbonaro, Luca A., additional, Contegiacomo, Alma, additional, Panizza, Pietro, additional, Di Cesare, Ernesto, additional, Savarese, Antonella, additional, Crecco, Marcello, additional, Turchetti, Daniela, additional, Tonutti, Maura, additional, Belli, Paolo, additional, and Maschio, Alessandro Del, additional

Published
2011
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25. Gadobenate dimeglumine-enhanced magnetic resonance angiography of the pelvic arteries.

Author

Wikstrom, J., Wasser, M.N., Pattynama, P.M., Bonomo, L., Hamm, B.K., Maschio, A. del, Knopp, M.V., Marchal, G., Barentsz, J.O., Oudkerk, M., Hentrich, H.R., Dapra, M., Kirchin, M.A., Shen, N., Spinazzi, A., Ahlstrom, H., Wikstrom, J., Wasser, M.N., Pattynama, P.M., Bonomo, L., Hamm, B.K., Maschio, A. del, Knopp, M.V., Marchal, G., Barentsz, J.O., Oudkerk, M., Hentrich, H.R., Dapra, M., Kirchin, M.A., Shen, N., Spinazzi, A., and Ahlstrom, H.

Abstract

Item does not contain fulltext, RATIONALE AND OBJECTIVES: To evaluate 4 doses of gadobenate dimeglumine (Gd-BOPTA) for contrast-enhanced magnetic resonance angiography (CE-MRA) of the pelvic arteries and to compare CE-MRA with unenhanced time-of-flight MRA (2D-TOF-MRA). METHODS: A multicenter Phase II dose-finding study was performed in 136 patients with Gd-BOPTA doses of 0.025, 0.05, 0.1, and 0.2 mmol/kg bodyweight. Evaluation of CE-MRA images and comparison with 2D-TOF-MRA images was performed onsite and by 2 blinded offsite reviewers in terms of subjective image quality, number of lesions detected, and confidence in lesion characterization. RESULTS: Significant (P < 0.05) improvements over unenhanced findings were observed for CE-MRA at all dose levels. For reviewer 1 and the onsite investigators, the overall image quality increased up to a dose of 0.1 mmol/kg and then plateaued. For reviewer 2, increased image quality was noted up to a dose of 0.2 mmol/kg. Significant (P < 0.005) increases in diagnostic confidence on CE-MRA versus unenhanced MRA was observed for all dose groups by reviewer 1 and the onsite investigators and for the 0.1 and 0.2 mmol/kg dose groups by reviewer 2. No serious adverse events were recorded that were attributable to the study drug and no trends in laboratory parameters, vital signs, or electrocardiogram recordings were observed. CONCLUSIONS: Gadobenate dimeglumine-enhanced MRA is safe and significantly more effective than unenhanced 2D-TOF-MRA for imaging the pelvic arteries. A dose of 0.1 mmol/kg appears the most appropriate dose for subsequent Phase III clinical evaluation.

Published
2003

26. Feasibility of safe ultra-high (EQD2>100 Gy) dose escalation on dominant intra-prostatic lesions (DILs) by Helical Tomotheraphy

Author

Maggio, Angelo, primary, Fiorino, Claudio, additional, Mangili, Paola, additional, Cozzarini, Cesare, additional, de Cobelli, Francesco, additional, Cattaneo, Giovanni Mauro, additional, Rancati, Tiziana, additional, Maschio, Alessandro Del, additional, Muzio, Nadia Di, additional, and Calandrino, Riccardo, additional

Published
2010
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28. Defining the optimal biological dose of NGR-hTNF, a selective vascular targeting agent, in advanced solid tumours

Author

Gregorc, Vanesa, primary, Citterio, Giovanni, additional, Vitali, Giordano, additional, Spreafico, Anna, additional, Scifo, Paola, additional, Borri, Anna, additional, Donadoni, Giovanni, additional, Rossoni, Gilda, additional, Corti, Angelo, additional, Caligaris-Cappio, Federico, additional, Maschio, Alessandro Del, additional, Esposito, Antonio, additional, De Cobelli, Francesco, additional, Dell’Acqua, Flavio, additional, Troysi, Antonella, additional, Bruzzi, Paolo, additional, Lambiase, Antonio, additional, and Bordignon, Claudio, additional

Published
2010
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29. Gadobenate dimeglumine-enhanced MR angiography of the abdominal aorta and renal arteries.

Author

Kroencke, T.J., Wasser, M.N., Pattynama, P.M., Barentsz, J.O., Grabbe, E., Marchal, G., Knopp, M.V., Schneider, G., Bonomo, L., Pennell, D.J., Maschio, A. del, Hentrich, H.R., Dapra, M., Kirchin, M.A., Spinazzi, A., Taupitz, M., Hamm, B.K., Kroencke, T.J., Wasser, M.N., Pattynama, P.M., Barentsz, J.O., Grabbe, E., Marchal, G., Knopp, M.V., Schneider, G., Bonomo, L., Pennell, D.J., Maschio, A. del, Hentrich, H.R., Dapra, M., Kirchin, M.A., Spinazzi, A., Taupitz, M., and Hamm, B.K.

Abstract

Item does not contain fulltext, OBJECTIVE: This study was conducted to determine the efficacy and safety of four different doses of gadobenate dimeglumine for contrast-enhanced three-dimensional MR angiography of the abdominal aorta and renal arteries. SUBJECTS AND METHODS: Ninety-four patients with suspected abnormality of the abdominal aorta or renal arteries underwent unenhanced three-dimensional gradient-recalled echo time-of-flight MR angiography and contrast-enhanced MR angiography after the IV injection of one of four doses of gadobenate dimeglumine (0.025, 0.05, 0.1, and 0.2 mmol/kg of body weight). Efficacy was assessed on-site and by two blinded off-site reviewers in terms of change in total diagnostic quality score and diagnostic quality score per vessel segment from baseline unenhanced time-of-flight MR angiography to contrast-enhanced MR angiography. Secondary efficacy end points included lesion count and level of confidence in lesion characterization. Safety assessments comprised adverse event monitoring, physical evaluation, vital signs, ECG, and laboratory investigations. RESULTS: A significant change in the total diagnostic quality score from unenhanced to contrast-enhanced MR angiography was observed at all doses. The change increased with increased dose, plateauing at the 0.1 mmol/kg dose level. More patients with lesions detected and increased reviewer confidence for lesion characterization were noted on contrast-enhanced MR angiography compared with unenhanced MR angiography, although no dose-related trends were observed. All doses were well tolerated, and no significant changes in safety parameters were observed. CONCLUSION: Gadobenate dimeglumine is an effective and safe agent for contrast-enhanced MR angiography of the abdominal aorta and renal arteries. A dose of 0.1 mmol/kg of body weight appears to be the most suitable.

Published
2002

32. Insulin resistance and whole body energy homeostasis in obese adolescents with fatty liver disease

Author

Perseghin, Gianluca, primary, Bonfanti, Riccardo, additional, Magni, Serena, additional, Lattuada, Guido, additional, De Cobelli, Francesco, additional, Canu, Tamara, additional, Esposito, Antonio, additional, Scifo, Paola, additional, Ntali, Georgia, additional, Costantino, Federica, additional, Bosio, Laura, additional, Ragogna, Francesca, additional, Maschio, Alessandro Del, additional, Chiumello, Giuseppe, additional, and Luzi, Livio, additional

Published
2006
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38. Renal Arterial Stenosis: Prospective Comparison of Color Doppler US and Breath-hold, Three-dimensional, Dynamic, Gadolinium-enhanced MR Angiography

Author

De Cobelli, Francesco, primary, Venturini, Massimo, additional, Vanzulli, Angelo, additional, Sironi, Sandro, additional, Salvioni, Marco, additional, Angeli, Enzo, additional, Scifo, Paola, additional, Garancini, Maria Paola, additional, Quartagno, Rita, additional, Bianchi, Giuseppe, additional, and Maschio, Alessandro Del, additional

Published
2000
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40. Comparison of clinical-radiological and molecular findings in hypochondroplasia

Author

Prinster, Chiara, primary, Carrera, Paola, additional, Maschio, Maurizia Del, additional, Weber, Giovanna, additional, Maghnie, Mohamad, additional, Vigone, Maria Cristina, additional, Mora, Stefano, additional, Tonini, Giorgio, additional, Rigon, Franco, additional, Beluffi, Giampiero, additional, Severi, Francesca, additional, Chiumello, Giuseppe, additional, and Ferrari, Maurizio, additional

Published
1998
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43. Near‐infrared interactance

Author

Brambilla, P, primary, Munzoni, P, additional, Beccaria, L, additional, Sironi, S, additional, Maschio, A Del, additional, and Chiumello, G, additional

Published
1994
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47. Endoscopic methylene blue test

Author

Pallini, P, primary, Costa, F, additional, Chiozzini, G, additional, Maschio, O Del, additional, Bortoluzzi, F, additional, Bettetto, G, additional, Tanturri, A, additional, and Staggioro, A, additional

Published
1993
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48. Feasibility of safe ultra-high (EQD2>100 Gy) dose escalation on dominant intra-prostatic lesions (DILs) by Helical Tomotheraphy.

Author

Maggio, Angelo, Fiorino, Claudio, Mangili, Paola, Cozzarini, Cesare, de Cobelli, Francesco, Cattaneo, Giovanni Mauro, Rancati, Tiziana, Maschio, Alessandro Del, Muzio, Nadia Di, and Calandrino, Riccardo

Subjects
RADIATION injuries, COMPUTER software, DIFFUSION, DOSE-response relationship (Radiation), MAGNETIC resonance imaging, PROSTATE tumors, RADIATION doses, RECTUM, STATISTICS, TOMOGRAPHY, PILOT projects, DATA analysis, PREVENTION
Abstract

Purpose. To verify the possibility of using Helical Tomotherapy to safely escalate dose to single or multiple highly radioresistant dominant intra-prostatic lesions (DILs) as assessed by functional magnetic resonance imaging (MRI). Material. In seven intermediate/high risk patients, T2WI, T1WI and DWI MRI imaging showed evidence of one DIL in four patients and two DILs in three patients in the peripheral zone of the prostate. The planning strategy was to deliver median doses of 80, 90, 100 and 120 Gy to PTVDIL while delivering 71.4 Gy/28 fractions (EQD2=75 Gy) to the remaining portion of PTV. A higher priority was assigned to rectal constraints relative to DIL coverage. Rectal NTCP calculations were performed using the most recently available model data. Results. The median dose to DIL could safely be escalated to at least 100 Gy (EQD2,α/β=10=113 Gy) without violating safe constraints for the organs at risk. Typical rectal NTCP values were around or below 1-3% for G3 toxicity and 5-7% for G2-G3 toxicity. For the 100 Gy DIL dose boost strategy, mean D95% of DIL and PTVDIL were 98.8 Gy and 86.7 Gy, respectively. The constraints for bladder, urethra and femoral heads were always respected. Conclusions. IGRT by Helical Tomotherapy may permit the safe escalation of EQD2,α/β=10 to at least 113 Gy to DILs without significantly increasing rectal NTCP compared to plans without dose escalation. A Phase I-II clinical study is warranted. [ABSTRACT FROM AUTHOR]

Published
2011
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49. Left ventricular function and energy metabolism in middle-aged men undergoing long-lasting sustained aerobic oxidative training.

Author

Perseghin, G, De Cobelli, F, Esposito, A, Belloni, E, Lattuada, G, Canu, T, Invernizzi, P L, Ragogna, F, La Torre, A, Scifo, P, Alberti, G, Maschio, A Del, and Luzi, L

Abstract

Objective: Ageing of the human heart is characterised by morphological, functional and metabolic changes. Short-term interventions and cross-sectional studies in older individuals questioned the possibility that physical exercise may reverse these alterations. In this study we aimed to assess whether in middle-aged men involved in regular and long lasting physical activity these alterations were attenuated. Design: Left ventricular (LV) magnetic resonance imaging (MRI) and three-dimensional image selected in-vivo spectroscopy (3D-ISIS) P magnetic resonance spectroscopy (MRS) were performed using a 1.5T scanner in 20 healthy, young and 25 healthy middle-aged non-obese men with a sedentary lifestyle (11 young and 14 middle-aged) or undergoing regular aerobic oxidative training (9 young and 11 middle-aged). Insulin sensitivity was estimated by the homeostatic model assessment 2 (HOMA-2) model. Results: Sedentary young and middle-aged men were not different with respect to LV morphological parameters and systolic function. The phosphocreatine/ATP (PCr/ATP) ratio (marker of high energy phosphates metabolism) and the LV E-peak filling rate/A-peak filling rate ratio (E/A ratio) were lower in sedentary middle-aged than physically active subjects. Parameters of LV systolic function and the PCr/ATP ratio were not different in the middle-aged compared with the young trained men; the E/A peak flow ratio was higher in the middle-aged trained men than in the middle-aged sedentary men. Within the entire population, the PCr/ATP ratio and the E/A peak flow ratio were associated with insulin sensitivity. Conclusions: Trained middle-aged subjects showed a better pattern of LV energy metabolism and of diastolic function than their sedentary counterparts. At this age the exercise-related cardiac benefits were detectable when physical exercise was performed regularly and for a long period of time. [ABSTRACT FROM PUBLISHER]

Published
2009

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