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Curcumin has various biological activities including antioxidant and antiinflammatory actions, and alcohol detoxification. However, because of its poor absorption efficiency, it is difficult for orally administered curcumin to reach blood levels sufficient to realize its bioactivities. We have generated capsules and tablets containing Theracurmin, a highly absorptive curcumin. In addition, we recently created a drinkable preparation of Theracurmin. To evaluate the absorption efficiency of this type of curcumin, we performed a single-dose, double-blind, 4-way crossover study. We compared plasma curcumin levels after the administration of Theracurmin beverage and 3 other drinkable types of curcumin sold in Japan. Twenty-four healthy subjects (male/female=13/11, age: 23-32) were administered with these 4 drinkable preparations of curcumin. The area under the blood concentration-time curve at 0-8 h was found to be 1.5 to 4.0-fold higher with Theracurmin than with the other 3 kinds of curcumin beverage. Moreover, maximal plasma curcumin concentrations (0-8 h) of Theracurmin were 1.8 to 3.8 times higher than those of the other 3 curcumin beverages. These data indicate that our newly prepared Theracurmin beverage exhibits a much better absorption efficiency than other kinds of curcumin beverage sold in Japan.

We investigated improvement of wavelength conversion performance of a SOA-DISC with MZDI phase offset and BPF detuning. With optimized conditions, power penalty of wavelength conversion output and transmission characteristics were improved.

A general procedure is proposed to treat a many-state atomic-collision problem involving both nonadiabatic radial and rotational couplings. The procedure is based on the classical $S$-matrix theory in a new "dynamical-state" representation. The dynamical states are defined as the eigenstates of a new Hamiltonian operator which is composed of an ordinary electronic Hamiltonian and a Coriolis coupling term. The dynamical potential energies thus obtained avoid crossings even for the rotationally coupled states. At these avoided crossing points the rotationally induced transitions predominantly occur, which are delocalized in the ordinary adiabatic-state representation. The theory is applied to certain two-state- and three-state-model problems, and is shown to work well. An interesting catalytic phenomenon is found in a three-state problem. A certain transition is enhanced by a rotational coupling not directly associated with that transition; besides, a transition directly induced by that rotational coupling is not affected by the coupling responsible for the first transition. This phenomenon can be successfully explained and reproduced by the theory. A condition is discussed for this kind of phenomenon to occur in a general many-state collision problem involving rotational couplings.

The Landau-Zener-Stueckelberg formula based on the “dynamical” adiabatic representation is shown to be useful for the study of the title transitions, The following two cases are investigated: (a) curve crossing at the finite internuclear distance ( R = R x ), (b) degeneracy at the united atom limit ( R =0).