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1. Abstracts of selected papers presented at the 30th Annual Meeting of the Japanese Society of Gastroenterology October 20–22, 1988 — Kagoshima, Japan

Author

Ichiro Oda, Kaoru Ogawa, Shuichi Okada, Keiichi Ueno, Tohru Itoh, Yuji Horiguchi, Hiroshi Kijima, Kazuo Inui, Akitoshi Koga, Tetsuro Hamamoto, Hideaki Tsukada, Takashi Tamada, Takahiko Nakamura, T. Okanoue, Daisuke Koike, Hirohiko Abe, Tsutomu Miura, Shuji Hashimoto, M. Oda, T. Azuma, Shigeyuki Nagata, Hiromasa Ishii, Norifumi Kawada, Yasuhiro Mizoguchi, Yuji Yoshikawa, Hiroshi Oka, Takafumi Ichida, Fumihiro Ichida, Takato Ueno, Kyuichi Tanikawa, Norihiro Kokudo, Seiji Kawasaki, Morikazu Onji, Hiroaki Miyaoka, Osamu Yokosuka, Masao Omata, Hiroshi Ikeda, Takao Tsuji, Shigeki Hayashi, Kenji Fujiwara, Mitsuru Yasunaga, Kiwamu Okita, Koujirou Takase, Yukihiko Tameda, Hiroo Ohnishi, Jun-ichi Sugihara, Hideo Kojima, Tomoteru Kamimura, Eiji Tanaka, Hidetoshi Yoda, Atsushi Kanno, Masao Ohtsuki, Yasuji Miyata, Shunichi Koga, Masashi Unoura, Nobuyoshi Tanaka, Takahiro Kodama, Hideo Nishimura, Kazuyuki Suzuki, Takeo Madarame, Masafumi Komatsu, Shunji Ookubo, Masataka Nishiyama, Shozo Saito, Ryukichi Kumashiro, Kenji Ikeda, Hiromitsu Kumada, Shuhei Nishiguchi, Tetsuo Kuroki, Makoto Yoshiba, Yukari Takeuchi, Takao Morito, Reiji Kasukawa, Isao Takeda, Satoshi Nakano, Kenzo Matsumura, Tomohiro Imanari, Shigeki Lee, Naotaka Fujita, Tetsuya Mine, Eiichi Sato, Masafumi Suyama, Jo Ariyama, Toshihisa Takahashi, Masanori Hirano, Atsushi Hirai, Tatsuo Yamakawa, Junichi Kamiya, Yuji Nimura, Hideo Yoshimoto, Seiyo Ikeda, Tadashi Yamasuji, Keizo Saeki, Masaki Itoh, Goro Kajiyama, Hideichi Seki, Ken Kimura, Hiroshi Nakamura, Yukihiro Tsuchiya, Ryosuke Omura, Shinya Tanaka, Katsuhide Shimakura, Yoshiaki Matsuda, Tokio Wakabayashi, Hideo Morimoto, Yasutaka Kamiya, Yasutaka Okayama, Masao Kobayashl, Sotaro Fujimoto, Atsumasa Yamaguchi, Tadashi Shibue, Ryukichi Akashi, Masahiro Hattori, Yasunori Takehira, Yasutoshi Tsugane, Yoshinori Tashiro, Hajime Kuwayama, Yoichi Kon, Tsugio Higuchi, Nobuto Hirata, Tomoyuki Kano, Kumiko Kurimoto, Y. Kubota, T. Seki, Yoshimine Kamura, Toshimichi Nakayama, Hitoshi Yoshimura, Tetsuya Yoshioka, Kimihiko Akimoto, Hirohide Ohnishi, Etsuro Ogata, Atsushi Igarashi, Atsushi Kadowaki, Tsutomu Yaoita, Naoki Sato, Kimitsune Monma, Hiroaki Kogure, Yoshio Tajima, Hideki Takanashi, Kazuo Haniya, Masao Ohto, Ikuo Murata, Takashi Tanaka, Takashi Sakabe, Takashi Kato, Tadashi Koike, Tetsuya Watanabe, Tetsuo Nakamura, H. Kato, I. Ikai, N. Nishimura, N. Kobayashi, K. Ozawa, Katsuyuki Ono, Michio Sata, Ken Kadowaki, Jiro Ikoma, Yuji Kojima, Tetsuya Murata, Ryuichi Kakehashi, Toshio Ibe, Uichiro Kano, Tetsuo Ito, Takeshi Tanaka, Shozo Watanabe, Shiro Suzuki, Osamu Nakazawa, Kyuhei Kohda, Kohzo Ohyama, Shoki Terada, Katsuhiko Sazaki, Teikichi Kure, Koetsu Morita, Osamu Shida, Hiroshi Muramatsu, Yoshiro Niitsu, Shinichi Tozuka, Yoshinori Sakai, Takaaki Ikeda, Wataru Koyama, Shigemi Sakamoto, Masaaki Kanayama, Naohide Tanaka, Yasuyuki Arakawa, Yutaka Matsuo, Kouichi Takaguchi, Gotaro Yamada, Kazuharu Matsuura, Hirosi Ikeda, Yoshiaki Iwasaki, Kazuhiro Nouso, Kazuhiro Matsueda, Masahiko Sawahara, Shigeatsu Fujiki, Motowo Mizuno, Shingo Kino Yama, Seijin Nadano, Norio Horiike, Kojiro Michitaka, Izumi Kumon, Yasushi Ogawa, Shuji Yamaguchi, Yasuyuki Ohta, Masaaki Nishi, Yasushi Matsuzaki, Naomi Tanaka, Hisashi Matsumoto, Yoshimichi Chuganji, Toshiaki Osuga, S. Shoji, M. Kurata, M. Wakashima, Y. Itoh, M. Hagiri, T. Kondou, M. Katayama, K. Nishizawa, H. Takikawa, H. Ohsawa, M. Miyake, M. Yamanaka, Teruji Ooka, Masahiko Akita, Hogen Kim, Michio Kato, Manabu Masuzawa, Takumasa Okuyama, Masahiko Akiyama, Yoshitaka Ishigami, Kazuya Tamura, Osamu Fukui, Hiroshi Abe, Takenobu Kamada, Ken Arai, Michiko Shindo, Tadao Okuno, Masayuki Matsumoto, Makoto Takeda, Tatsuro Takino, Yoshihiro Sokawa, M. Omata, O. Yokosuka, Y. Ito, K. Hosoda, M. Ohto, Yoshinobu Fuse, Tadashi Kodama, Kenji Sugiyama, Shinobu Nakajo, Shin Ajitsu, Tsuneo Takahashi, K. Kuroe, Y. Murata, and Hideo Ikeda

Subjects
Gerontology, medicine.medical_specialty, Surgical oncology, business.industry, Internal medicine, General surgery, Gastroenterology, medicine, Hepatology, business, Colorectal surgery, Abdominal surgery
Published
1990
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2. Ultrasonographical Diagnosis of Fatty Liver: Significance of the Liver-Kidney Contrast

Author

Hiroshi Suzuki, Yoshiaki Yajima, Ryuzo Abe, Kei Ohta, Masao Ohtsuki, and Takashi Narui

Subjects
Liver Cirrhosis, Pathology, medicine.medical_specialty, media_common.quotation_subject, Renal parenchyma, Kidney, General Biochemistry, Genetics and Molecular Biology, medicine, Humans, Contrast (vision), Lobules of liver, Obesity, Abdominal Muscles, Ultrasonography, media_common, Ultrasound study, medicine.diagnostic_test, business.industry, Fatty liver, Ultrasound, General Medicine, medicine.disease, Fatty Liver, medicine.anatomical_structure, Liver, Liver biopsy, sense organs, Radiology, business
Abstract

In order to investigate the reliability of ultrasonography in the diagnosis of fatty liver, retrospective evaluation was made of abdominal echograms in 45 patients with various diffuse liver diseases who underwent liver biopsy within 2 weeks after the ultrasound study. Instead of the well-recognized but subjective diagnostic criterion, i.e. the bright liver pattern, liver-kidney contrast is proposed as a new criterion. The liver-kidney contrast is based on the brightness of the liver in comparison to the renal parenchyma where fatty change seldom occurs. Combination of this liver-kidney contrast with two other well-known ultrasonographical findings of fatty liver, vascular blurring and deep attenuation, enables us to grade fatty change semiquantitatively. When fatty change of over 30% in the hepatic lobule was adopted as the definition of fatty liver, the satisfaction of both liver-kidney contrast and vascular blurring presented an ultrasound diagnostic criterion for fatty liver, with sensitivity of 83%, specificity of 100%, and an accuracy of 96%.

Published
1983
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3. The lipid-chemical features of the metastatic tissues into the liver from the human gastric cancer, large intestinal cancer and malignant insulinoma

Author

Masao Ohtsuki, Yoshio Goto, and Ichiro Nakazawa

Subjects
Pathology, medicine.medical_specialty, Phospholipid, Surgical operation, General Biochemistry, Genetics and Molecular Biology, chemistry.chemical_compound, Stomach Neoplasms, Intestinal Neoplasms, Biopsy, medicine, Humans, Intestine, Large, Neoplasm Metastasis, Phospholipids, Triglycerides, chemistry.chemical_classification, medicine.diagnostic_test, Triglyceride, business.industry, Fatty Acids, Liver Neoplasms, Fatty acid, Cancer, General Medicine, Large intestinal, Adenoma, Islet Cell, medicine.disease, Lipids, Malignant insulinoma, Pancreatic Neoplasms, chemistry, lipids (amino acids, peptides, and proteins), business
Abstract

In order to clarify the biochemical features of metastatic tissues into the liver of human cancerous cells, 12 of primary cancerous tissues and 3 of metastatic tissues of the large intestinal cancer, 6 of primary cancerous tissues and 2 of metastatic tissues of the gastric cancer, and 3 of primary cancerous tissues and 3 of metastatic tissues of malignant insulinoma were studied lipid-chemically. Cancerous tissues and metastatic tissues into the liver were collected by biopsy or surgical operation. From each tissue, the total lipid was extracted and one part of the total lipid was separated into phospholipid and triglyceride by TLC. Then, the fatty acid composition and the fatty acid content of each lipid fraction were measured by GLC. The most remarkable findings were recognized in the phospholipid fatty acid composition of the tissues. Namely, the percentage values of C14:0 and C16:1 were larger and that of C20:4 was smaller in metastatic tissues than those of gastric primary lesions. As for the large intestinal cancer, the percentage value of C18:1 was smaller and that of C18:2 larger in metastatic tissues than those of primary lesions. In the malignant insulinoma, the percentage value of C18:0 was larger in metastatic tissues than that of the primary lesions.

Published
1978
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4. An autopsy case of systemic lupus erythematosus with progressive liver dysfunction

Author

Takeshi Sasaki, Kaoru Yoshinaga, Yoichi Ohtuka, Eiichi Tamate, Tai Muryoi, Hiroshi Suzuki, Takefumi Kadono, Chikashi Sasaki, Takayuki Masuda, Yukio Sekiguchi, Masao Ohtsuki, Kazuo Mori, Kei Yamakage, Osamu Takai, and Yuichi Michimata

Subjects
Thesaurus (information retrieval), Pathology, medicine.medical_specialty, business.industry, Immunology, Immunology and Allergy, Medicine, General Medicine, Autopsy case, Liver dysfunction, business, Anti-SSA/Ro autoantibodies
Published
1986
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5. [Untitled]

Author

Yoshiaki YAJIMA, Kei OHTA, Takashi NARUI, Ryuzo ABE, Hiroshi SUZUKI, and Masao OHTSUKI

Subjects
Hepatology
Published
1982
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6. [Untitled]

Author

Ryuzo Abe, Takashi Narui, Masao Ohtsuki, Kenji Yamada, Yoshiaki Yajima, Yoshio Goto, Motoyasu Ishii, Masatoshi Ito, and Satoshi Endo

Subjects
Hepatology, medicine.diagnostic_test, business.industry, Lipid content, Fatty liver, Medicine, Computed tomography, Nuclear medicine, business, medicine.disease
Published
1981
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7. Proceedings of the 69th General Meeting from April 11–13, 1983-Osaka, Japan

Author

Yoshihiro Baba, Kunio Nagata, Yoshihisa Tsukada, Rintaro Narisawa, Akira Honma, Shinichi Hirose, Mineo Tomizawa, Toshihiko Ozaki, Fumihiro Ichida, Kenji Tanehiro, Nobuyoshi Kuno, Kumiko Kurimoto, Tetsuo Yokota, Tomoyuki Kano, Tatsuzo Kasugai, Kazuya Ueno, Katsuhide Shimakura, Akira Kakita, Masaaki Kambayashi, Tsuyoshi Takahashi, Eisei Sasaki, Yoichi Kasai, Toshihisa Takahashi, S. Shimaguchi, J. Ariyama, Masatoshi Sumida, Yukihiro Tsuchiya, Masao Ohto, Fumio Asagami, Tadasu Fuji, Norimasa Okabe, Kenji Sakurai, Shuichi Miyakawa, Yuji Horiguchi, Hiroshi Nakano, Yuji Nimura, N. Hayakawa, H. Hasegawa, J. Kamiya, S. Maeda, Y. Iyomasa, Yoshiro Matsumoto, Katsuhiko Sugahara, T. Ida, R. Mashimo, Shu Kou Wen, H. Fujii, S. Wakashiro, G. Isowa, S. Itoh, T. Yamakawa, Hidenori Udaka, Hideyuki Miyamoto, Toshikazu Tamura, Tsutomu Hirai, Osamu Okamura, Nobuhiko Komi, Nobuo Yoshioka, Yoshio Kawamura, Takahiko Kojima, Hitoshi Hachiya, Nobuyoshi Okumura, Kunihiko Suzuki, Toshiyuki Suzuki, Sadasuke Suzuki, Norishige Ozeki, Kazuo Goto, Shigehiro Shiraki, Toshihiko Takeuchi, Atsumasa Yamaguchi, Tadashi Shibue, Yukimitsu Kawaura, Takashi Iwa, Isao Takeda, Satoshi Nakano, Tomoko Kobayashi, Hideo Harada, Tokio Wakabayashi, Norio Sawabu, Yasuo Naito, Saburo Nakazawa, Tomoaki Isawa, Ikuo Tabata, Yuichi Sasaki, Hideaki Yamada, Shunichi Tatsumi, Kenzo Kobayashi, Eitaro Suzuki, Eizo Okamoto, Masakatsu Matsukawa, Toshio Nakanishi, Hiroiku Kawakami, Sotaro Fujimoto, Masatsugu Nakajima, Junichi Sugihara, Yoichi Saitoh, Takashi Matsushiro, Hideyuki Nagashima, Kyoji Yamamoto, Ryuji Nakamura, Junichi Tanaka, Fumito Shimizu, Takashi Toshima, Tuneo Hariu, Takukazu Nagakawa, Noriyoshi Suzuki, Wataru Takahashi, Ikunoshin Uematsu, Toshio Sato, K. Egami, T. Tajiri, N. Aoki, K. Yamaguchi, H. Yamakawa, A. Watanabe, M. Yano, S. Hatta, M. Yoshioka, M. Miki, A. Shirota, Koji Morimoto, Masato Furukawa, Toshinori Nakata, Ryuhei Yamada, Shinichiro Ito, Shigeru Maeda, Toshinori Morinaga, Makota Tanigawa, Toshiyuki Fujio, Hiroshi Inui, Hiroaki Kinoshita, Osamu Yamasaki, Eiichi Nagata, Kazuhiro Hirohashi, null Sakai, Tadahiro Takada, Hideki Yasuda, Makoto Shishikura, Katsuhiro Uchiyama, Yoshifumi Ogura, Ryuji Mizumoto, Kazuomi Nakazawa, Shunichi Sato, Isamu Kaito, Hiroshi Suzuki, Masao Ohtsuki, Yoshio Goto, M. Nomoto, K. Yunoue, K. Soga, F. Ichida, Y. Koike, K. Kiyosawa, Y. Akahane, K. Kamijyo, Y. Suzuki, S. Yamamura, T. Komatsu, A. Nagata, S. Furuta, Shigeki Hayashi, Yasuhiko Ohta, Kenji Fujiwara, Yuzuru Sato, Itsuro Ogata, Katsuyoshi Takatsuki, Shunji Mishiro, Hiroshi Oka, Masaru Furube, Nobuo Yamada, Hisao Shibata, Akitaka Shibuya, Eishi Hijikata, Shigenobu Kokubu, Kohdo Ishii, Haruya Okabe, Kenichi Sasaki, Akira Takada, Jugoro Takeuchi, Yasuyuki Ohta, Tadashi Tsujii, Fumiaki Ikegame, Masashi Unoura, Akihiko Furusawa, Nobuyoshi Tanaka, Yasuhiro Kato, Kenichi Kobayashi, Nobu Hattori, Yukihiko Tameda, Satoshi Kakiuchi, Yoshitane Kosaka, Shigeyoshi Harihara, Sukeo Yamamoto, Gotaro Yamada, Hideo Nagashima, Morikazu Onji, Yoshimasa Yamashita, Norio Horiike, Hirohiko Abe, Kazuhiko Hino, Masaru Kojima, Kazunori Noguchi, Hiromu Ueda, Tomoki Aritaka, Naoto Maruyama, Hitoshi Motoori, Kazuaki Yamauchi, Hiroshi Setoyama, Michio Sata, Yasuhiko Kubo, Kyuichi Tanikawa, Tatsuo Munehisa, Keisuke Nakata, Kenzo Kono, Toyoichi Muro, Akira Sato, Ryuji Furukawa, Nobuko Ishii, Yukio Kusumoto, Toshihiko Koji, Shigenobu Nagataki, Norio Nakao, Kohi Miura, Y. Sato, Y. Ohta, I. Ogata, S. Hayashi, K. Fujiwara, H. Oka, S. Furui, M. Iio, Kenji Ikeda, Eiji Oyake, Kazuo Takeuchi, Hiromitsu Kumada, Masao Nakajima, Akira Yoshiba, Masahiro Irimoto, Toshio Kobayashi, Morio Satoh, Ryusaku Yamada, Haruki Nakatsuka, Kenji Hirai, Masanobu Kumagai, Genjiro Yamaguchi, Masatoshi Tanaka, Masanobu Abe, Keijiro Ando, Yasushi Shingai, Kiwamu Okita, Tadayoshi Takemoto, Kazuo Tarao, Kenichiro Iwamura, Kenji Soga, Minoru Nomoto, Hitoshi Takagi, Takafumi Ichida, Shunsaku Higashi, Takashi Noguchi, Takashi Kanematsu, Kenji Takenaka, Takashi Matsumata, Takashi Sonoda, Toshiya Furuta, Keizo Sugimachi, Kiyoshi Inokuchi, Susumu Yamasaki, Hiroshi Hasegawa, Masatoshi Makuuchi, Yoshimi Nakanishi, Hidekazu Sano, Tetsuro Konno, Fumio Sano, Toshiharu Tsuzuki, Shuhei Iida, Naoki Yamanaka, Keiji Kuwata, Akihiro Toyosaka, Nobutaka Tanaka, Shiro Fujiwara, Hajime Yamazaki, Katsuji Sakai, Tokio Ono, Hiroaki Yamada, Masahiro Tada, Hitoshi Asakura, Kensuke Kobayashi, Tetsuo Morishita, Masaharu Tsuchiya, Nobutaka Sato, Hideo Hiratsuka, N. Ueda, and K. Harada

Subjects
medicine.medical_specialty, business.industry, Internal medicine, Gastroenterology, Library science, Medicine, business
Published
1984
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8. Liver lipids in patients with endogenous hypertriglyceridemia

Author

Akira Ohneda, Masao Ohtsuki, Ryuzo Abe, Akira Yanbe, Hiroshi Tadaki, Shoichi Yamagata, and Yoshisuke Maruhama

Subjects
Adult, Male, medicine.medical_specialty, Hyperlipidemias, Oleic Acids, ENDOGENOUS HYPERTRIGLYCERIDEMIA, Fatty Acids, Nonesterified, General Biochemistry, Genetics and Molecular Biology, chemistry.chemical_compound, Internal medicine, medicine, Humans, In patient, Phospholipids, Triglycerides, Triglyceride, business.industry, Hypertriglyceridemia, Fatty Acids, General Medicine, Middle Aged, medicine.disease, Lipids, Cholesterol blood, Oleic acid, Endocrinology, Cholesterol, chemistry, Linoleic Acids, Liver, lipids (amino acids, peptides, and proteins), Female, Liver triglyceride, business, Liver pathology
Abstract

Analyses of liver lipids revealed that triglyceride was increased significantly but not other lipids in patients with endogenous hypertriglyceridemia. Oleic acid was most increased among the fatty acids of liver triglyceride. The liver triglyceride content was varied from patient to patient. No significant correlation was found between the increase in liver triglyceride and the degree of hypertriglyceridemia.

Published
1974

9. Virological significance of HBeAg subtypes (HBeAg/1 and HBeAg/2) in patients with type B hepatitis

Author

Motoyasu Ishii, Keizaburoh Matsuda, Atsushi Kanno, Masao Ohtsuki, Hitoshi Ohori, Yutaka Miyazaki, Yoshio Goto, Hiroshi Suzuki, and Haruo Nakayama

Subjects
Adult, Male, HBsAg, medicine.medical_specialty, Hepatitis B virus, Immunodiffusion, Cirrhosis, viruses, medicine.disease_cause, Gastroenterology, Immunoenzyme Techniques, Internal medicine, medicine, Humans, Hepatitis B e Antigens, Hepatitis, Chronic, Hepatitis, Hepatitis B Surface Antigens, Hepatology, business.industry, virus diseases, Nucleic Acid Hybridization, medicine.disease, Hepatitis B, Virology, Hepatitis B Core Antigens, digestive system diseases, HBcAg, Viral replication, HBeAg, Carrier State, DNA, Viral, Female, business
Abstract

In order to establish the virological significance of HBeAg subtypes (HBeAg/1 and HBeAg/2) during hepatitis B virus infection, HBsAg, HBeAg and hepatitis B virus DNA in serum and HBcAg in liver were determined quantitatively in relation to the detection of HBeAg subtypes in agar gel diffusion. Thirty-eight chronic HBsAg carriers with HBeAg, including 16 non-specific reactive hepatitis, 8 chronic persistent hepatitis, 11 chronic active hepatitis and 3 liver cirrhosis, who were seen at Tohoku University Hospital from 1983 to 1985, were examined. Significantly larger amounts of HBsAg, HBeAg and hepatitis B virus DNA in serum and HBcAg in liver were found in patients positive for both HBeAg/1 and HBeAg/2 in serum than in those positive for only HBeAg/1 or negative for both subtypes. These results suggest that the presence of HBeAg/2 in serum may reflect the occurrence of active viral replication. When the detection pattern of HBeAg subtypes was examined during serial follow-up for at least 1 year, three groups of patients were classified with respect to the presence of HBeAg/2, i.e., Type I, consistently positive for HBeAg/2; Type II, consistently negative for HBeAg/2, and Type III, intermittently positive for HBeAg/2. More than 80% of Type I patients were histologically diagnosed having as nonspecific reactive hepatitis, while more than 80% of Type II and III patients had more progressive liver diseases such as chronic persistent hepatitis, chronic active hepatitis and liver cirrhosis. These results suggest that the serial examination of HBeAg subtypes in serum may be important for more detailed evaluations of type B hepatitis.

Published
1987

10. Hepatic steatosis and the elevated plasma insulin level in patients with endogenous hypertriglyceridemia

Author

Akira Ohneda, Shoichi Yamagata, Yoshisuke Maruhama, Akira Yanbe, Hiroshi Tadaki, Masao Ohtsuki, and Ryuzo Abe

Subjects
Adult, Blood Glucose, Male, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Hyperlipidemias, ENDOGENOUS HYPERTRIGLYCERIDEMIA, Fatty Acids, Nonesterified, Elevated plasma insulin, chemistry.chemical_compound, Endocrinology, Internal medicine, medicine, Hyperinsulinemia, Humans, Insulin, In patient, Obesity, Triglycerides, Aged, Glucose tolerance test, Triglyceride, medicine.diagnostic_test, business.industry, Glucose Tolerance Test, Middle Aged, medicine.disease, Fatty Liver, Cholesterol, chemistry, Liver, Female, Steatosis, business
Abstract

Among 31 nonobese or obese patients with endogenous hypertriglyceridemia, hepatic steatosis was found by histologic examination of the biopsied specimen in 17 patients, and it was severe in six patients, They had no history of excessive alcohol intake. Chemical analysis revealed that the lipid accumulated in the liver was triglyceride. The hypertriglyceridemic patients, with or without histologic steatosis, showed significantly increased responses of both plasma insulin and blood glucose to oral glucose load compared with control subjects. The responses were more exaggerated in the hypertriglyceridemic patients with steatosis than in the hypertriglyceridemic patients without steatosis. Analysis of correlations between five variables (liver triglyceride, plasma insulin, blood glucose, body weight index, and serum triglyceride) was done on 15 subjects whose liver triglyceride values were quantified, and highly significant correlations were found between liver triglyceride and plasma insulin, blood glucose, or body weight index. A step wise multiple regression analysis performed on the five variables with liver triglyceride as the dependent variable revealed that the plasma insulin level was the most closely related variable, and the blood glucose level the next. The prediction equation for liver triglyceride as a function of plasma insulin and blood glucose levels (r = 0.91, p greater than 0.001) accounted for 84 percent of the total variance of liver triglyceride. It was shown that the decay of intravenously injected insulin in plasma was not delayed in the hypertriglyceridemic patients with steatosis, while the insulin sensitivity examined after intravenous insulin injection significantly decreased in the hypertriglyceridemic patients with or without steatosis, thus suggesting that the hyperinsulinemia in the hypertriglyceridemic patients was due to an increased insulin secretion associated with the decrease in the insulin sensitivity. Therefore, the elevated plasma insulin and blood glucose levels--or the insulin insensitivity by itself--might be the essential abnormalities in patients with endogenous hypertriglyceridemia, which, in extreme cases, might lead to massive triglyceride accumulation in the liver.

Published
1975

11. Computed tomography in the diagnosis of fatty liver: total lipid content and computed tomography number

Author

Masatoshi Ito, Motoyasu Ishii, Ryuzo Abe, Masao Ohtsuki, Satoshi Endo, Yoshio Goto, Yoshiaki Yajima, Takashi Narui, and Kenji Yamada

Subjects
Liver Cirrhosis, medicine.medical_specialty, Cirrhosis, N-group (finite group theory), Computed tomography, Chronic liver disease, Gastroenterology, General Biochemistry, Genetics and Molecular Biology, Hepatitis, Liver disease, Internal medicine, Hounsfield scale, medicine, Humans, health care economics and organizations, medicine.diagnostic_test, Chemistry, Fatty liver, Lipid metabolism, General Medicine, medicine.disease, Lipid Metabolism, Fatty Liver, Liver, Chronic Disease, Radiology, Tomography, X-Ray Computed
Abstract

Fifty-three histologically proved cases of various diffuse liver disease were studied for their computed tomography numbers (CTN). The machine used was Ohio Nuclear's Delta Scanner 50FS type and CTN was expressed by the Hounsfield unit (H). Mean CTN in each group was as follows: 66.6 +/- 2.6 H in normal control (N), 63.3 +/- 6.0 H in chronic hepatitis (CH). 61.8 +/- 7.0 H in liver cirrhosis (LC), and 44.4 +/- 10.6 H in fatty infiltration (FI). There were no significant differences among them except FI group. As N group were all above 60 H and CH and LC groups were all above 50 H, CTN below 60 H suggests chronic liver disease or fatty infiltration and CTN below 50 H strongly suggests fatty infiltration. In eleven cases where total lipid content of the liver could be be biochemically determined by the sulfo-phospho-vanillin reagent, a relation of total lipid content to CTN was studied. As a result, a significant correlation existed between them (r = -0.89; p less than 0.001). If the diagnostic criterion of fatty liver was set at total lipid content above 100 mg/g wet liver, CT criterion was estimated at CTN below 48 H from the regression formula.

Published
1982

12. A case of idiopathic fatty liver detectable only by ultrasonography

Author

Kei Ohta, Ryuzo Abe, Takashi Narui, Yoshiaki Yajima, Hiroshi Suzuki, and Masao Ohtsuki

Subjects
Adult, Male, Pathology, medicine.medical_specialty, Gastroenterology, General Biochemistry, Genetics and Molecular Biology, Diabetes mellitus, Internal medicine, Hyperlipidemia, Medicine, Humans, Ultrasonography, medicine.diagnostic_test, business.industry, Fatty liver, General Medicine, medicine.disease, Fatty Liver, medicine.anatomical_structure, Liver, Biliary tract, Liver biopsy, Etiology, business, Pancreas, Liver function tests, Tomography, X-Ray Computed
Abstract

YAJIMA, Y., OHTA, K., NARUI, T., ABE, R., SUZUKI, H. and OHTSUKI, M. A Case of Idiopathic Fatty Liver Detectable Only by Ultrasonography. Tohoku J. exp. Med., 1983, 140 (3), 273-278-A 40-year-old man was diagnosed as fatty liver according to our ultrasonographical criteria for fatty liver, i.e., liver-kidney contrast in the ultrasound mass screening of the liver, biliary tract and pancreas. He lacked any signs or symptoms, nor any known causes of fatty liver, i.e, obesity, diabetes, hyperlipidemia, ingestion of alcohol or drugs. Liver biopsy of this patient revealed fatty change of about 50% of the hepatic lobules. It has been difficult to suspect the presence of latent fatty liver which lacked both the abnormality in the liver function test and hepatomegaly, and even impossible when it lacked any risk factors. In the future as the ultrasonography becomes more generally used as a primary screening examination, “idiopathic latent fatty liver”, like this patient, will be more frequently found and this, in turn, will contribute to the progress of the epidemiology and etiology of fatty liver.

Published
1983

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