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5 results on '"Masanobu Tanemoto"'

1. Interleukin 9 mediates T follicular helper cell activation to promote antibody responses

Author

Taiki Sato, Ippei Ikegami, Masahiro Yanagi, Takeshi Ohyu, Taiki Sugaya, Shotaro Shirato, Masanobu Tanemoto, Shiori Kamiya, Kohei Kikuchi, Yuka Kamada, Takehito Nakata, Ryuta Kamekura, Akinori Sato, Ken-ichi Takano, Masahiro Miyajima, Atsushi Watanabe, and Shingo Ichimiya

Subjects
follicular mantle zone B cells, germinal center response, IL-9, ILC2, leukotrienes, T follicular helper cells, Immunologic diseases. Allergy, RC581-607
Abstract

Antigen-specific humoral responses are orchestrated through complex interactions among immune cells in lymphoid tissues, including the collaboration between B cells and T follicular helper (Tfh) cells. Accumulating evidence indicates a crucial role for interleukin-9 (IL-9) in the formation of germinal centers (GCs), enhancing the generation of class-switched high-affinity antibodies. However, the exact function of IL-9 in Tfh cell regulation remains unclear. In this study, we examined the humoral immune responses of CD4Cre/+Il9rafl/fl mice, which lack an IL-9-specific receptor in Tfh cells. Upon intraperitoneal immunization with sheep red blood cells (SRBCs), CD4Cre/+Il9rafl/fl mice displayed diminished levels of SRBC-specific IgG antibodies in their sera, along with reduced levels of GC B cells and plasma cells. Notably, Il9ra-deficient Tfh cells in the spleen exhibited decreased expression of their signature molecules such as B-cell lymphoma 6, C-X-C chemokine receptor 5, IL-4, and IL-21 compared to control mice. In models of allergic asthma induced by house dust mite (HDM) inhalation, CD4Cre/+Il9rafl/fl mice failed to elevate serum levels of HDM-specific IgE and IgG. This was accompanied by reductions in Tfh cells, GC B cells, and plasma cells in mediastinal lymph nodes. Furthermore, group 2 innate lymphoid cells (ILC2s) were identified as producers of IL-9 under immunizing conditions, possibly induced by leukotrienes released by activated IgD+ B cells around the T-B border. These observations may indicate the critical role of IL-9 receptor signaling in the activation of Tfh cells, with ILC2s potentially capable of supplying IL-9 in organized lymphoid tissues.

Published
2024
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2. Anti-signal Recognition Particle Antibody-positive Immune-mediated Myopathy after mRNA-1273 SARS-CoV-2 Vaccination

Author

Masanobu, Tanemoto, Ryosuke, Oda, Yuichiro, Toyama, Hirohiko, Shizukawa, Kazuki, Yokokawa, Taro, Saito, Syuuichirou, Suzuki, Akihiro, Matsumura, and Shin, Hisahara

Subjects
Adult, COVID-19 Vaccines, SARS-CoV-2, Vaccination, COVID-19, Myalgia, General Medicine, Muscular Diseases, Internal Medicine, Humans, Female, Signal Recognition Particle, 2019-nCoV Vaccine mRNA-1273, Autoantibodies
Abstract

A 26-year-old Japanese woman developed a fever, myalgia and gait disturbance one day after receiving the second dose of the mRNA-1273 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine. A neurological examination revealed symmetrical weakness and myalgia in proximal lower limbs, and a blood examination showed prominent elevation of creatinine kinase. Magnetic resonance imaging (MRI) revealed a high signal intensity in the thigh muscles on short-tau inversion recovery images, and antibody testing revealed positive findings for anti-signal recognition particle (SRP) antibody. Thus, anti-SRP antibody-positive immune-mediated myopathy was diagnosed. We initiated immunotherapy, and she was ultimately able to walk stably.

Published
2022
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3. Sporadic Amyotrophic Lateral Sclerosis Due to a FUS P525L Mutation with Asymmetric Muscle Weakness and Anti-ganglioside Antibodies

Author

Masanobu Tanemoto, Kazuna Ikeda, Kazuki Yokokawa, Akihiro Matsumura, Tatsuo Manabe, Takashi Matsushita, Shun Shimohama, Shin Hisahara, Reiko Tsuda, Syuuichirou Suzuki, and Daisuke Yamamoto

Subjects
Adult, amyotrophic lateral sclerosis, Pathology, medicine.medical_specialty, anti-ganglioside antibody, Mismatch negativity, Case Report, 030204 cardiovascular system & hematology, fused in sarcoma, 03 medical and health sciences, 0302 clinical medicine, Gangliosides, Internal Medicine, Humans, Medicine, Amyotrophic lateral sclerosis, FUS, Muscle Weakness, Ganglioside, biology, business.industry, Muscle weakness, General Medicine, medicine.disease, P525L mutation, Mutation, Mutation (genetic algorithm), biology.protein, RNA-Binding Protein FUS, Female, 030211 gastroenterology & hepatology, Sarcoma, medicine.symptom, Antibody, business, Multifocal motor neuropathy
Abstract

Amyotrophic lateral sclerosis (ALS) due to a fused in sarcoma (FUS) P525L mutation is characterized by a rapidly progressive course. Multifocal motor neuropathy (MMN) may resemble ALS in early stage and is associated with anti-ganglioside antibodies. A 38-year-old woman was admitted to our hospital because of progressive muscle weakness in the right limbs. She had mild mental retardation and minor deformities. Initially, we suspected MMN given the asymmetric muscle weakness and detection of anti-ganglioside antibodies. However, physical and electrophysiological tests did not support MMN, instead suggesting ALS. We confirmed a heterozygous P525L mutation and finally diagnosed this case as ALS due to an FUS mutation.

Published
2021
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5. Severe Mononeuritis Multiplex due to Rheumatoid Vasculitis in Rheumatoid Arthritis in Sustained Clinical Remission for Decades

Author

Bungo Hirose, Shin Hisahara, Shuichiro Suzuki, Masanobu Tanemoto, Takashi Matsushita, Tatsuo Manabe, Tomihiro Imai, Shun Shimohama, and Kazuna Ikeda

Subjects
rheumatoid arthritis, medicine.medical_specialty, medicine.medical_treatment, malignant rheumatoid arthritis, Azathioprine, Case Report, Rheumatoid Vasculitis, 030204 cardiovascular system & hematology, mononeuritis multiplex, Arthritis, Rheumatoid, 03 medical and health sciences, 0302 clinical medicine, Rheumatoid Factor, Internal Medicine, Medicine, Rheumatoid factor, Humans, Aged, 80 and over, business.industry, Mononeuritis Multiplex, Mononeuropathies, Muscle weakness, Immunosuppression, General Medicine, medicine.disease, Dermatology, Rheumatoid arthritis, Rheumatoid vasculitis, 030211 gastroenterology & hepatology, Polyarthritis, Female, medicine.symptom, business, Immunosuppressive Agents, medicine.drug
Abstract

Rheumatoid vasculitis (RV) usually occurs in patients with refractory rheumatoid arthritis (RA). An 80-year-old woman was transferred to our hospital because of muscle weakness and paresthesia in all 4 limbs. She had been diagnosed with RA 30 years ago and achieved sustained clinical remission. At presentation, polyarthritis and drop foot were observed, and rheumatoid factor was prominently elevated. A peripheral nerve conduction test revealed mononeuritis multiplex in her limbs. We suspected that RV had developed rapidly despite RA having been stable for many years and started immunosuppression therapy with steroids combined with azathioprine. The treatment prevented worsening of muscle weakness and paresthesia.

Published
2019

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