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1. Clinical management of older, frail patients with atrial fibrillation. The proposal of a multidisciplinary working group

Author

Marchionni, N, Fumagalli, S, Bo, M, Boccanelli, A, Boriani, G, Rubboli, A, Violi, F, Di Pasquale, G, Beer, B, Colonna, P, Manetti, L, Pilleri, A, Purificato, F, Ruotolo, G, Sciacqua, A, Taberini, L, Turcato, E, Bozzato, S, Catanzariti, D, Felici, M, Florio, C, Fontana, F, Giomi, A, Masala, R, Mascia, G, Nassiacos, D, Nesti, M, Okoye, C, Pestelli, G, Bassi, V, Curci, S, D'Avino, M, Doimo, S, Faustino, M, Gemmiti, M, Pignatelli, P, Sarli, G, Stefanoni, P, Ciccone, M, Diemberger, I, Gragnano, F, Serafini, F, Marchionni N., Fumagalli S., Bo M., Boccanelli A., Boriani G., Rubboli A., Violi F., Di Pasquale G., Beer B., Colonna P., Manetti L. L., Pilleri A., Purificato F., Ruotolo G., Sciacqua A., Taberini L., Turcato E., Bozzato S., Catanzariti D., Felici M., Florio C., Fontana F., Giomi A., Masala R., Mascia G., Nassiacos D., Nesti M., Okoye C., Pestelli G., Bassi V., Curci S., D'Avino M., Doimo S., Faustino M., Gemmiti M. P., Pignatelli P., Sarli G., Stefanoni P., Ciccone M., Diemberger I., Gragnano F., Serafini F., Marchionni, N, Fumagalli, S, Bo, M, Boccanelli, A, Boriani, G, Rubboli, A, Violi, F, Di Pasquale, G, Beer, B, Colonna, P, Manetti, L, Pilleri, A, Purificato, F, Ruotolo, G, Sciacqua, A, Taberini, L, Turcato, E, Bozzato, S, Catanzariti, D, Felici, M, Florio, C, Fontana, F, Giomi, A, Masala, R, Mascia, G, Nassiacos, D, Nesti, M, Okoye, C, Pestelli, G, Bassi, V, Curci, S, D'Avino, M, Doimo, S, Faustino, M, Gemmiti, M, Pignatelli, P, Sarli, G, Stefanoni, P, Ciccone, M, Diemberger, I, Gragnano, F, Serafini, F, Marchionni N., Fumagalli S., Bo M., Boccanelli A., Boriani G., Rubboli A., Violi F., Di Pasquale G., Beer B., Colonna P., Manetti L. L., Pilleri A., Purificato F., Ruotolo G., Sciacqua A., Taberini L., Turcato E., Bozzato S., Catanzariti D., Felici M., Florio C., Fontana F., Giomi A., Masala R., Mascia G., Nassiacos D., Nesti M., Okoye C., Pestelli G., Bassi V., Curci S., D'Avino M., Doimo S., Faustino M., Gemmiti M. P., Pignatelli P., Sarli G., Stefanoni P., Ciccone M., Diemberger I., Gragnano F., and Serafini F.

Abstract

Atrial fibrillation (AF) is the most common arrhythmia in elderly people. Older patients with AF have several comorbidities and should be treated with complex therapeutic schemes. Arrhythmia complications are also common at an advanced age. Accordingly, AF can be considered a marker of frailty. Few indications can be found concerning the management of frail older subjects in current guidelines. The Frailty in Atrial Fibrillation Survey Study (FAST) was designed to overcome the gap of knowledge about this extremely vulnerable subset of patients. A multidisciplinary team composed by cardiologists, geriatricians and internists participated in the project. In a first phase, a survey was conducted aiming at clarifying specialty-related differences in definition and oral anticoagulant therapy (OAT) management of frail individuals. In the second phase, specific chapters were prepared about AF and frailty epidemiology, the network for the management of the arrhythmia, the diagnostic strategies for AF (including a minimum data set of tools derived from the geriatric multidimensional assessment), OAT and the choice between a rate or a rhythm control strategy. For each chapter, up-to-date evidence and current guideline recommendations were presented and discussed among the 47 Italian centers participating in the project. In the last phase of FAST, the results of the survey and the final draft of the chapters were merged into the present document. A lack of homogeneity in frailty definition existed. The integration among cardiologists, geriatricians and internists can represent the most effective tool to get through these differences improving the management of frail older patients.

Published
2021

2. Cardiometabolic multimorbidity is associated with a worse Covid-19 prognosis than individual cardiometabolic risk factors: a multicentre retrospective study (CoViDiab II)

Author

Maddaloni, E., D'Onofrio, L., Alessandri, F., Mignogna, C., Leto, G., Pascarella, G., Mezzaroma, I., Lichtner, M., Pozzilli, P., Agro, F. E., Rocco, M., Pugliese, F., Lenzi, A., Holman, R. R., Mastroianni, C. M., Buzzetti, R., Ajassa, C., Alban, R., Alessi, F., Aronica, R., Belvisi, V., Candy, M., Caputi, A., Carrara, A., Casali, E., Cavallari, E. N., Ceccarelli, G., Celani, L., Ciardi, M. R., Coraggio, L., Curtolo, A., D'Agostino, C., D'Ettorre, G., De Giorgi, F., De Girolamo, G., Filippi, V., Gnessi, L., Luordi, C., Moretti, C., Recchia, G., Ridolfi, M., Romani, F. E., Russo, G., Ruberto, F., Savelloni, G., Siccardi, G., Siena, A., Sterpetti, S., Valeri, S., Vera, M., Volpicelli, L., Watanabe, M., Aiuti, M., Campagna, G., Del Borgo, C., Fondaco, L., Kertusha, B., Leonetti, F., Marocco, R., Masala, R., Zuccala, P., Nonnis, G., Rigoli, A., Strumia, A., and Alampi, D.

Subjects
lcsh:Diseases of the circulatory (Cardiovascular) system, medicine.medical_specialty, multimorbidity, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Pneumonia, Viral, pandemics, Logistic regression, metabolic diseases, law.invention, coronavirus infections, male, law, Diabetes mellitus, Internal medicine, middle aged, medicine, 80 and over, copd, covid-19, diabetes, hypertension, sars-cov-2, aged, cardiovascular diseases, diabetes mellitus, female, follow-up studies, humans, pneumonia, viral, prognosis, retrospective studies, risk factors, betacoronavirus, COPD, Original Investigation, Aged, 80 and over, Mechanical ventilation, business.industry, SARS-CoV-2, Confounding, Diabetes, Retrospective cohort study, Odds ratio, medicine.disease, Intensive care unit, lcsh:RC666-701, Hypertension, Cardiology and Cardiovascular Medicine, business, Covid-19
Abstract

Background Cardiometabolic disorders may worsen Covid-19 outcomes. We investigated features and Covid-19 outcomes for patients with or without diabetes, and with or without cardiometabolic multimorbidity. Methods We collected and compared data retrospectively from patients hospitalized for Covid-19 with and without diabetes, and with and without cardiometabolic multimorbidity (defined as ≥ two of three risk factors of diabetes, hypertension or dyslipidaemia). Multivariate logistic regression was used to assess the risk of the primary composite outcome (any of mechanical ventilation, admission to an intensive care unit [ICU] or death) in patients with diabetes and in those with cardiometabolic multimorbidity, adjusting for confounders. Results Of 354 patients enrolled, those with diabetes (n = 81), compared with those without diabetes (n = 273), had characteristics associated with the primary composite outcome that included older age, higher prevalence of hypertension and chronic obstructive pulmonary disease (COPD), higher levels of inflammatory markers and a lower PaO2/FIO2 ratio. The risk of the primary composite outcome in the 277 patients who completed the study as of May 15th, 2020, was higher in those with diabetes (Adjusted Odds Ratio (adjOR) 2.04, 95%CI 1.12–3.73, p = 0.020), hypertension (adjOR 2.31, 95%CI: 1.37–3.92, p = 0.002) and COPD (adjOR 2.67, 95%CI 1.23–5.80, p = 0.013). Patients with cardiometabolic multimorbidity were at higher risk compared to patients with no cardiometabolic conditions (adjOR 3.19 95%CI 1.61–6.34, p = 0.001). The risk for patients with a single cardiometabolic risk factor did not differ with that for patients with no cardiometabolic risk factors (adjOR 1.66, 0.90–3.06, adjp = 0.10). Conclusions Patients with diabetes hospitalized for Covid-19 present with high-risk features. They are at increased risk of adverse outcomes, likely because diabetes clusters with other cardiometabolic conditions.

Published
2020

6. The methodology of the Italian HBSC 2010 study (Health Behaviour in School-aged Children)

Author

Lazzeri, G, Giacchi, M, Dalmasso, P, Vieno, A, Nardone, P, Lamberti, A, Spinelli, A, Cavallo, F, Lemma, P, Berchialla, P, Colombini, S, Zambon, A, Charrier, L, Borraccino, A, Pilato, V, Rossi, S, Pammolli, A, Santinello, M, Chieco, F, Lenzi, M, Baglio, G, Galeone, D, Spizzichino, L, Menzano, M, Scotti, M, Silani, M, Teti, S, Ciglia, A, Di Giacomo, M, Spinosa, S, Ammirati, G, Cauzillo, G, Sorrentino, G, Azzarito, C, La Rocca, M, Pizzuti, R, Mazzarella, G, Di Martino, E, Angelini, P, Fridel, M, Bavcar, A, Castronuovo, G, Pascali, F, Celata, C, Tosi, M, Velasco, V, Bonfanti, M, Coppola, L, Giostra, G, Ciallella, M, Caputo, M, Viesti, E, Rosa, G, Anelli, S, Meloni, S, Senis, M, Masala, R, Cernigliaro, A, Rizzo, S, Giannoni, A, Cristofori, M, Covarino, A, D'Alessandro, G, Piffer, S, Fanolla, A, Weiss, S, Lazzeri G., Giacchi M. V., Dalmasso P., Vieno A., Nardone P., Lamberti A., Spinelli A., Cavallo F., Lemma P., Berchialla P., Colombini S., Zambon A., Charrier L., Borraccino A., Pilato V., Rossi S., Pammolli A., Santinello M., Chieco F., Lenzi M., Baglio G., Galeone D., Spizzichino L., Menzano M. T., Scotti M. T., Silani M. T., Teti S., Ciglia A., Di Giacomo M., Spinosa S., Ammirati G., Cauzillo G., Sorrentino G., Azzarito C., La Rocca M., Pizzuti R., Mazzarella G., Di Martino E., Angelini P., Fridel M., Bavcar A., Castronuovo G. C. E., Pascali F., Celata C., Tosi M., Velasco V., Bonfanti M., Coppola L., Giostra G., Ciallella M. L., Caputo M., Viesti E., Rosa G., Anelli S., Meloni S., Senis M. L., Masala R., Cernigliaro A., Rizzo S., Giannoni A. M., Cristofori M., Covarino A. M., D'alessandro G., Piffer S., Fanolla A., Weiss S., Lazzeri, G, Giacchi, M, Dalmasso, P, Vieno, A, Nardone, P, Lamberti, A, Spinelli, A, Cavallo, F, Lemma, P, Berchialla, P, Colombini, S, Zambon, A, Charrier, L, Borraccino, A, Pilato, V, Rossi, S, Pammolli, A, Santinello, M, Chieco, F, Lenzi, M, Baglio, G, Galeone, D, Spizzichino, L, Menzano, M, Scotti, M, Silani, M, Teti, S, Ciglia, A, Di Giacomo, M, Spinosa, S, Ammirati, G, Cauzillo, G, Sorrentino, G, Azzarito, C, La Rocca, M, Pizzuti, R, Mazzarella, G, Di Martino, E, Angelini, P, Fridel, M, Bavcar, A, Castronuovo, G, Pascali, F, Celata, C, Tosi, M, Velasco, V, Bonfanti, M, Coppola, L, Giostra, G, Ciallella, M, Caputo, M, Viesti, E, Rosa, G, Anelli, S, Meloni, S, Senis, M, Masala, R, Cernigliaro, A, Rizzo, S, Giannoni, A, Cristofori, M, Covarino, A, D'Alessandro, G, Piffer, S, Fanolla, A, Weiss, S, Lazzeri G., Giacchi M. V., Dalmasso P., Vieno A., Nardone P., Lamberti A., Spinelli A., Cavallo F., Lemma P., Berchialla P., Colombini S., Zambon A., Charrier L., Borraccino A., Pilato V., Rossi S., Pammolli A., Santinello M., Chieco F., Lenzi M., Baglio G., Galeone D., Spizzichino L., Menzano M. T., Scotti M. T., Silani M. T., Teti S., Ciglia A., Di Giacomo M., Spinosa S., Ammirati G., Cauzillo G., Sorrentino G., Azzarito C., La Rocca M., Pizzuti R., Mazzarella G., Di Martino E., Angelini P., Fridel M., Bavcar A., Castronuovo G. C. E., Pascali F., Celata C., Tosi M., Velasco V., Bonfanti M., Coppola L., Giostra G., Ciallella M. L., Caputo M., Viesti E., Rosa G., Anelli S., Meloni S., Senis M. L., Masala R., Cernigliaro A., Rizzo S., Giannoni A. M., Cristofori M., Covarino A. M., D'alessandro G., Piffer S., Fanolla A., and Weiss S.

Abstract

Italy has participated in the Health Behaviour in School-aged Children (HBSC) study since 2000. These surveys collect data every four years on the well-being and health behaviour of boys and girls aged 11, 13 and 15. Until 2007, the coordination group of the University of Turin, Siena and Padua directly sent the questionnaires to each sampled school to collect the data. The sample of about 4500 students was nationally representative. In 2008 the HBSC became part of the project "Surveys on behavioral risks in children aged 6-17 years", coordinated by the National Institute of Health (ISS) and promoted by the Ministry of Health, in collaboration with the Ministry of Education, University and Research. For the first time, in 2010, the survey was conducted by health workers in collaboration with teachers in all regions with a representative sample, not just at the national level, but also at regional level. In the 2,504 sampled schools, 77,113 students (25,079 eleven-year-old, 26,048 thirteen-year-old and 25,986 fifteen-year-old) completed an anonymous questionnaire. Knowledge of the health-related behaviour of school-aged adolescents may help monitoring and enable policies for young people to be formulated and implemented.

Published
2013

7. Screening for colorectal cancer in Italy: 2011-2012 survey

Author

Zorzi, Manuel, Da Re, Filippo, Mantellini, Paola, Naldoni, Carlo, De Bianchi, Priscilla Sassoli, Senore, Carlo, Turrin, Anna, Visioli, Carmen Beatriz, Zappa, Marco, Crotta, S., Senore, C., Polizzi, S., Sartori, M., Alibrandi, M. P., Germinetti, F., Bestagini, P., Orione, L., Miroglio, T., Faragli, G., Cereda, D., Coppola, L., Zerbi, L., Gramegna, M., Tessandri, L., Imbrogno, P., Rocca, G., Pesenti, B., Schivardi, M., Crisetig, M., Grassi, E., Speziani, F., Gola, G., Gotti, S., Dal Soldà, M., Boldori, L., Moretti, G., Ilardo, A., Ieni, A, Belloni, A., Rossetti, E., Marazza, G., Anghinoni, E., Silvestri, A., Tidone, E., Frammartino, B., Leonardo, N., Deandrea, S., Ceresa, P., Beghi, G., Lucchini, R., Acerbi, L., Lo Buono, F., Cavalieri D'Oro, L., Magenes, G., Camana, L., Cioccarelli, A. M., Fanetti, A. C., Cecconami, L., Bardelli, R., Violini, M., Sambo, F., Domenighini, S., Pieracci, G., Pertile, R., Piffer, S., Fedato, C., Franzo, A., Fabro, J., Gobbato, M., Zanier, L., Bonelli, L., Orlando, M., Vaccari, D., Franxo, A., Scotto, M., Valle, I., Ferrari Bravo, M., Sticchi, C., Maddalo, F., Pensa, F., Naldoni, C., Sassoli De Bianchi, P., Landi, P., Borciani, E., Fornari, F., Gatti, G., Zurlini, C., Zatelli, M., Maradini, F., Paterlini, L., Campari, C., Sassatelli, R., Corradini, R., Goldoni, C., Pasquini, A., Manfredi, M., Baldazzi, P., Nannini, R., Caprara, L., Carpanelli, M. C., Zoli, G., Matarese, V., Triossi, O., Serafini, M., Vitali, B., Falcini, F., Colamartini, A., Giuliani, O., Vattiato, R., Palazzi, M., Imolesi, C., Pazzi, P., Canuti, D., Casale, C., Giovanardi, M., Monticelli, G., Nicolai, C., Vivani, P., Giorgi, D., Finucci, G., Rapanà, M., Epifani, C., Abdelghani, L., Allegrini, G., Maffei, C., Turillazzi, R., Mirri, F., Ceccatelli, P., Rosati, R., Piacentini, P., Visioli, C. B., Falini, P., Amico, P., Ciabattoni, C., Giaimo, M., Prandini, S., Vinti, G., Di Marco, A., Malaspina, M., Corvetti, R., Di Furia, L., Barca, A., Baiocchi, D., Quadrino, F., Di Giacomo, M., Lattanzio, F. M., Minna, M., Di Credico, A., Pizzuti, R., Sigillito, A., Montesi, M. P., Landro, T., Giorno, A., Santino, M., Magrì, G., Ferrara, G., and Masala, R.

Subjects
Flexible sigmoidoscopy, National survey, Faecal immunochemical test, Italy, Colorectal cancer, Screening, Epidemiology, Public Health, Environmental and Occupational Health, Environmental and Occupational Health, Public Health
Published
2015

14. Evaluation of pituitary-thyroid axis response to acute myocardial infarction

Author

Marinis, L., Mancini, A., Masala, R., Torlontano, M., Sandric, S., and Barbarino, A.

Abstract

We have studied with seriated controls for a period of 9 days 18 patients admitted to our hospital for acute myocardial infarction (AMI). Slight, but non significant variations in thyroidal hormone pattern were observed: slight decrease of T3and T4levels, increase of reverse T3on day 3, low free T4levels, slight increase of TSH levels until the 3rd day. However, hormonal pattern was clearly different in patients who presented a clinical improvement (group Ia) and in patients who died for AMI (group Ib). In fact, a significant TSH increase was recorded in patients of group Ia; on the contrary, a significant decrease of TSH, T4and free T4concentrations was observed for subjects of group lb, suggesting an inadequate response of pituitary-thyroid axis. In conclusion, the evaluation of thyroid hormones and thyrotropin levels can be of clinical usefulness in the management of patients with AMI. The decrease of plasma T4and free T4concentrations, accompanied with low TSH levels, can be associated with unfavorable course of the disease and therefore can be considered a bad prognostic sign.

Published
1985
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15. The methodology of the Italian HBSC 2010 study (Health Behaviour in School-aged Children)

Author

Lazzeri G., Giacchi M. V., Dalmasso P., Vieno A., Nardone P., Lamberti A., Spinelli A., Cavallo F., Lemma P., Berchialla P., Colombini S., Zambon A., Charrier L., Borraccino A., Pilato V., Rossi S., Pammolli A., Santinello M., Chieco F., Lenzi M., Baglio G., Galeone D., Spizzichino L., Menzano M. T., Scotti M. T., Silani M. T., Teti S., Ciglia A., Di Giacomo M., Spinosa S., Ammirati G., Cauzillo G., Sorrentino G., Azzarito C., La Rocca M., Pizzuti R., Mazzarella G., Di Martino E., Angelini P., Fridel M., Bavcar A., Castronuovo G. C. E., Pascali F., Celata C., Tosi M., Velasco V., Bonfanti M., Coppola L., Giostra G., Ciallella M. L., Caputo M., Viesti E., Rosa G., Anelli S., Meloni S., Senis M. L., Masala R., Cernigliaro A., Rizzo S., Giannoni A. M., Cristofori M., Covarino A. M., D'alessandro G., Piffer S., Fanolla A., Weiss S., Lazzeri, G, Giacchi, M, Dalmasso, P, Vieno, A, Nardone, P, Lamberti, A, Spinelli, A, Cavallo, F, Lemma, P, Berchialla, P, Colombini, S, Zambon, A, Charrier, L, Borraccino, A, Pilato, V, Rossi, S, Pammolli, A, Santinello, M, Chieco, F, Lenzi, M, Baglio, G, Galeone, D, Spizzichino, L, Menzano, M, Scotti, M, Silani, M, Teti, S, Ciglia, A, Di Giacomo, M, Spinosa, S, Ammirati, G, Cauzillo, G, Sorrentino, G, Azzarito, C, La Rocca, M, Pizzuti, R, Mazzarella, G, Di Martino, E, Angelini, P, Fridel, M, Bavcar, A, Castronuovo, G, Pascali, F, Celata, C, Tosi, M, Velasco, V, Bonfanti, M, Coppola, L, Giostra, G, Ciallella, M, Caputo, M, Viesti, E, Rosa, G, Anelli, S, Meloni, S, Senis, M, Masala, R, Cernigliaro, A, Rizzo, S, Giannoni, A, Cristofori, M, Covarino, A, D'Alessandro, G, Piffer, S, Fanolla, A, and Weiss, S

Subjects
Male, School, Sampling Studie, Adolescent, Health Behavior, Child Behavior, Risk Assessment, Teenagers, Sampling Studies, Healthy behaviour, epidemiological surveillance, teenagers, Risk-Taking, Risk Factors, Surveys and Questionnaires, Humans, Surveys and Questionnaire, Sex Distribution, Students, Child, Schools, Risk Factor, Epidemiological surveillance, Teenager, Italy, Health Survey, Health Surveys, Research Design, Adolescent Behavior, Female, Student, Human
Abstract

Italy has participated in the Health Behaviour in School-aged Children (HBSC) study since 2000. These surveys collect data every four years on the well-being and health behaviour of boys and girls aged 11, 13 and 15. Until 2007, the coordination group of the University of Turin, Siena and Padua directly sent the questionnaires to each sampled school to collect the data. The sample of about 4500 students was nationally representative. In 2008 the HBSC became part of the project "Surveys on behavioral risks in children aged 6-17 years", coordinated by the National Institute of Health (ISS) and promoted by the Ministry of Health, in collaboration with the Ministry of Education, University and Research. For the first time, in 2010, the survey was conducted by health workers in collaboration with teachers in all regions with a representative sample, not just at the national level, but also at regional level. In the 2,504 sampled schools, 77,113 students (25,079 eleven-year-old, 26,048 thirteen-year-old and 25,986 fifteen-year-old) completed an anonymous questionnaire. Knowledge of the health-related behaviour of school-aged adolescents may help monitoring and enable policies for young people to be formulated and implemented.

16. Screening for colorectal cancer in Italy: 2011-2012 survey

Author

Zorzi, M., Da Re, F., Mantellini, P., Naldoni, C., Bianchi, P. S., Senore, C., Turrin, A., Visioli, C. B., Zappa, M., Crotta, S., Polizzi, S., Sartori, M., Alibrandi, M. P., Germinetti, F., Bestagini, P., Orione, L., Miroglio, T., Faragli, G., Cereda, D., Coppola, L., Zerbi, L., Gramegna, M., Tessandri, L., Imbrogno, P., Rocca, G., Pesenti, B., Schivardi, M., Crisetig, M., Grassi, E., Speziani, F., Gola, G., Gotti, S., Dal Soldà, M., Boldori, L., Moretti, G., Ilardo, A., Belloni, A., Rossetti, E., Marazza, G., Anghinoni, E., Silvestri, A., Tidone, E., Frammartino, B., Leonardo, N., Deandrea, S., Ceresa, P., Beghi, G., Lucchini, R., Acerbi, L., Lo Buono, F., Cavalieri D Oro, L., Magenes, G., Camana, L., Cioccarelli, A. M., Fanetti, A. C., Cecconami, L., Bardelli, R., Violini, M., Sambo, F., Domenighini, S., Pieracci, G., Pertile, R., Piffer, S., Fedato, C., Franzo, A., Fabro, J., Gobbato, M., Zanier, L., Bonelli, L., Orlando, M., Vaccari, D., Franxo, A., Scotto, M., Valle, I., Ferrari Bravo, M., Sticchi, C., Maddalo, F., Pensa, F., Sassoli Bianchi, P., Landi, P., Borciani, E., Fornari, F., Gatti, G., Zurlini, C., Zatelli, M., Maradini, F., Paterlini, L., Cinzia Campari, Sassatelli, R., Corradini, R., Goldoni, C., Pasquini, A., Manfredi, M., Baldazzi, P., Nannini, R., Caprara, L., Carpanelli, M. C., Zoli, G., Matarese, V., Triossi, O., Serafini, M., Vitali, B., Falcini, F., Colamartini, A., Giuliani, O., Vattiato, R., Palazzi, M., Imolesi, C., Pazzi, P., Canuti, D., Casale, C., Giovanardi, M., Monticelli, G., Nicolai, C., Vivani, P., Giorgi, D., Finucci, G., Rapanà, M., Epifani, C., Abdelghani, L., Allegrini, G., Maffei, C., Turillazzi, R., Mirri, F., Ceccatelli, P., Rosati, R., Piacentini, P., Falini, P., Amico, P., Ciabattoni, C., Giaimo, M., Prandini, S., Vinti, G., Di Marco, A., Malaspina, M., Corvetti, R., Di Furia, L., Barca, A., Baiocchi, D., Quadrino, F., Di Giacomo, M., Lattanzio, F. M., Minna, M., Di Credico, A., Pizzuti, R., Sigillito, A., Montesi, M. P., Landro, T., Giorno, A., Santino, M., Magrì, G., Ferrara, G., and Masala, R.

17. Screening for colorectal cancer in Italy: 2011-2012 survey

Author

Zorzi, M., Da Re, F., Mantellini, P., Naldoni, C., Bianchi, P. S., Senore, C., Turrin, A., Visioli, C. B., Zappa, M., Crotta, S., Polizzi, S., Sartori, M., Alibrandi, M. P., Germinetti, F., Bestagini, P., Orione, L., Miroglio, T., Faragli, G., danilo Cereda, Coppola, L., Zerbi, L., Gramegna, M., Tessandri, L., Imbrogno, P., Rocca, G., Pesenti, B., Schivardi, M., Crisetig, M., Grassi, E., Speziani, F., Gola, G., Gotti, S., Dal Soldà, M., Boldori, L., Moretti, G., Ilardo, A., Belloni, A., Rossetti, E., Marazza, G., Anghinoni, E., Silvestri, A., Tidone, E., Frammartino, B., Leonardo, N., Deandrea, S., Ceresa, P., Beghi, G., Lucchini, R., Acerbi, L., Lo Buono, F., Cavalieri D Oro, L., Magenes, G., Camana, L., Cioccarelli, A. M., Fanetti, A. C., Cecconami, L., Bardelli, R., Violini, M., Sambo, F., Domenighini, S., Pieracci, G., Pertile, R., Piffer, S., Fedato, C., Franzo, A., Fabro, J., Gobbato, M., Zanier, L., Bonelli, L., Orlando, M., Vaccari, D., Franxo, A., Scotto, M., Valle, I., Ferrari Bravo, M., Sticchi, C., Maddalo, F., Pensa, F., Sassoli Bianchi, P., Landi, P., Borciani, E., Fornari, F., Gatti, G., Zurlini, C., Zatelli, M., Maradini, F., Paterlini, L., Campari, C., Sassatelli, R., Corradini, R., Goldoni, C., Pasquini, A., Manfredi, M., Baldazzi, P., Nannini, R., Caprara, L., Carpanelli, M. C., Zoli, G., Matarese, V., Triossi, O., Serafini, M., Vitali, B., Falcini, F., Colamartini, A., Giuliani, O., Vattiato, R., Palazzi, M., Imolesi, C., Pazzi, P., Canuti, D., Casale, C., Giovanardi, M., Monticelli, G., Nicolai, C., Vivani, P., Giorgi, D., Finucci, G., Rapanà, M., Epifani, C., Abdelghani, L., Allegrini, G., Maffei, C., Turillazzi, R., Mirri, F., Ceccatelli, P., Rosati, R., Piacentini, P., Falini, P., Amico, P., Ciabattoni, C., Giaimo, M., Prandini, S., Vinti, G., Di Marco, A., Malaspina, M., Corvetti, R., Di Furia, L., Barca, A., Baiocchi, D., Quadrino, F., Di Giacomo, M., Lattanzio, F. M., Minna, M., Di Credico, A., Pizzuti, R., Sigillito, A., Montesi, M. P., Landro, T., Giorno, A., Santino, M., Magrì, G., Ferrara, G., and Masala, R.

18. Neck circumference as reliable predictor of mechanical ventilation support in adult inpatients with COVID-19: A multicentric prospective evaluation.

Author

Di Bella S, Cesareo R, De Cristofaro P, Palermo A, Sanson G, Roman-Pognuz E, Zerbato V, Manfrini S, Giacomazzi D, Dal Bo E, Sambataro G, Macchini E, Quintavalle F, Campagna G, Masala R, Ottaviani L, Del Borgo C, Ridola L, Leonetti F, Berlot G, and Luzzati R

Subjects
Adult, Aged, COVID-19 epidemiology, COVID-19 therapy, COVID-19 virology, Female, Humans, Italy epidemiology, Male, Middle Aged, Predictive Value of Tests, Prospective Studies, Survival Rate, COVID-19 mortality, Neck pathology, Respiration, Artificial statistics & numerical data, SARS-CoV-2 isolation & purification
Abstract

Aims: COVID-19 is especially severe for elderly subjects with cardiometabolic and respiratory comorbidities. Neck circumference (NC) has been shown to be strongly related to cardiometabolic and respiratory illnesses even after adjustment for body mass index (BMI). We performed a prospective study to investigate the potential of NC to predict the need for invasive mechanical ventilation (IMV) in adult COVID-19 inpatients., Materials and Methods: We prospectively and consecutively enrolled COVID-19 adult patients admitted to dedicated medical wards of two Italian hospitals from 25 March to 7 April 2020. On admission, clinical, biochemical and anthropometric data, including BMI and NC were collected. As primary outcome measure, the maximum respiratory support received was evaluated. Follow-up time was 30 days from hospital admission., Results: We enrolled 132 subjects (55.0-75.8 years, 32% female). During the study period, 26 (19.7%) patients underwent IMV. In multivariable logistic regression analyses, after adjusting for age, sex, diabetes, hypertension and COPD, NC resulted independently and significantly associated with IMV risk (adjusted OR 1.260-per 1 cm increase 95% CI:1.120-1.417; P < .001), with a stronger association in the subgroup with BMI ≤30 Kg/m 2 (adjusted OR 1.526; 95% CI:1.243-1.874; P < .001). NC showed a good discrimination power in predicting patients requiring IMV (AUC 0.783; 95% CI:0.684-0.882; P < .001). In particular, NC > 40.5 cm (>37.5 for females and >42.5 for males) showed a higher and earlier IMV risk compared to subjects with lower NC (Log-rank test: P < .001)., Conclusions: NC is an easy to measure parameter able to predict the need for IMV in adult COVID-19 inpatients., (© 2020 John Wiley & Sons Ltd.)

Published
2021
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19. Clinical Discussions in Antithrombotic Therapy Management in Patients With Atrial Fibrillation: A Delphi Consensus Panel.

Author

Mumoli N, Amellone C, Antonelli G, Augello G, Cloro C, D'Alleva A, Ascenzo LD, Imbalzano E, Masala R, Riccioni G, Romeo E, Rossi L, Santoro G, Sciatti E, Tondo A, Toso E, Venturini E, Vizzardi E, and Mascioli G

Abstract

Background: In recent years, direct-acting oral anticoagulants (DOACs) have entered clinical practice for stroke prevention in non-valvular atrial fibrillation or prevention and treatment of venous thromboembolism. However, remaining uncertainty regarding DOAC use in some clinical scenarios commonly encountered in the real world has not been fully explored in clinical trials., Methods: We report on use of a Delphi consensus process on DOAC use in non-valvular atrial fibrillation patients. The consensus process dealt with 9 main topics: (i) DOACs vs vitamin K antagonists in atrial fibrillation (AF) patients; (ii) therapeutic options for patients with stable total time in range treated with vitamin K antagonists; (iii) therapeutic options for patients aged > 85 years; (iv) therapeutic management of hyperfiltering patients; (v) pharmacologic interactions; (vi) therapeutic options in the long-term treatment (prevention) of patients with AF and acute coronary syndrome after the triple therapy; (vii) low doses of DOACs in AF patients; (viii) ischemic stroke in patients inappropriately treated with low doses of DOACs; (ix) management of patients taking DOACs with left atrial appendage thrombosis., Results: A total of 101 physicians (cardiologists, internists, geriatricians, and hematologists) from Italy expressed their level of agreement on each statement by using a 5-point Likert scale (1 = strongly disagree; 2 = disagree; 3 = somewhat agree; 4 = agree; 5 = strongly agree). Votes 1-2 were considered to be disagreement; votes 3-5 were considered to be agreement. Agreement among the respondents of ≥ 66% for each statement was considered consensus. A brief discussion of the results for each topic is also reported., Conclusions: In clinical practice, there is still uncertainty on DOAC use, especially in elderly, fragile, comorbid, and hyperfiltering patients., (© 2020 Canadian Cardiovascular Society. Published by Elsevier Inc.)

Published
2020
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20. Mitotic slippage and expression of survivin are linked to differential sensitivity of human cancer cell-lines to the Kinesin-5 inhibitor monastrol.

Author

Asraf H, Avunie-Masala R, Hershfinkel M, and Gheber L

Subjects
Apoptosis drug effects, Blotting, Western, Cell Cycle drug effects, Cell Proliferation drug effects, Humans, Inhibitor of Apoptosis Proteins antagonists & inhibitors, Inhibitor of Apoptosis Proteins genetics, Kinesins genetics, Kinesins metabolism, Neoplasms metabolism, Neoplasms pathology, RNA, Messenger genetics, RNA, Small Interfering genetics, Real-Time Polymerase Chain Reaction, Reverse Transcriptase Polymerase Chain Reaction, Spindle Apparatus drug effects, Survivin, Tumor Cells, Cultured, Drug Resistance, Neoplasm drug effects, Inhibitor of Apoptosis Proteins metabolism, Kinesins antagonists & inhibitors, Mitosis drug effects, Neoplasms drug therapy, Pyrimidines pharmacology, Thiones pharmacology
Abstract

The mitotic Kinesin-5 motor proteins crosslink and slide apart antiparallel spindle microtubules, thus performing essential functions in mitotic spindle dynamics. Specific inhibition of their function by monastrol-like small molecules has been examined in clinical trials as anticancer treatment, with only partial success. Thus, strategies that improve the efficiency of monastrol-like anticancer drugs are required. In the current study, we examined the link between sensitivity to monastrol and occurrence of mitotic slippage in several human cell-lines. We found that the rank of sensitivity to monastrol, from most sensitive to least sensitive, is: AGS > HepG2 > Lovo > Du145 ≥ HT29. We show correlation between the sensitivity of a particular cell-line to monastrol and the tendency of the same cell-line to undergo mitotic slippage. We also found that in the monastrol resistant HT29 cells, prolonged monastrol treatments increase mRNA and protein levels of the chromosomal passenger protein survivin. In contrast, survivin levels are not increased by this treatment in the monastrol-sensitive AGS cells. We further show that over-expression of survivin in the monastrol-sensitive AGS cells reduces mitotic slippage and increases resistance to monastrol. Finally, we show that during short exposure to monastrol, Si RNA silencing of survivin expression reduces cell viability in both AGS and HT29 cells. Our data suggest that the efficiency of anti-cancer treatment with specific kinesin-5 inhibitors may be improved by modulation of expression levels of survivin.

Published
2015
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21. Phospho-regulation of kinesin-5 during anaphase spindle elongation.

Author

Avunie-Masala R, Movshovich N, Nissenkorn Y, Gerson-Gurwitz A, Fridman V, Kõivomägi M, Loog M, Hoyt MA, Zaritsky A, and Gheber L

Subjects
CDC2 Protein Kinase genetics, CDC2 Protein Kinase metabolism, Kinesins genetics, Microtubules genetics, Microtubules metabolism, Phosphorylation, Protein Transport, Saccharomyces cerevisiae cytology, Saccharomyces cerevisiae genetics, Saccharomyces cerevisiae Proteins genetics, Spindle Apparatus genetics, Anaphase, Kinesins metabolism, Saccharomyces cerevisiae metabolism, Saccharomyces cerevisiae Proteins metabolism, Spindle Apparatus metabolism
Abstract

The kinesin-5 Saccharomyces cerevisiae homologue Cin8 is shown here to be differentially phosphorylated during late anaphase at Cdk1-specific sites located in its motor domain. Wild-type Cin8 binds to the early-anaphase spindles and detaches from the spindles at late anaphase, whereas the phosphorylation-deficient Cin8-3A mutant protein remains attached to a larger region of the spindle and spindle poles for prolonged periods. This localization of Cin8-3A causes faster spindle elongation and longer anaphase spindles, which have aberrant morphology. By contrast, the phospho-mimic Cin8-3D mutant exhibits reduced binding to the spindles. In the absence of the kinesin-5 homologue Kip1, cells expressing Cin8-3D exhibit spindle assembly defects and are not viable at 37°C as a result of spindle collapse. We propose that dephosphorylation of Cin8 promotes its binding to the spindle microtubules before the onset of anaphase. In mid to late anaphase, phosphorylation of Cin8 causes its detachment from the spindles, which reduces the spindle elongation rate and aids in maintaining spindle morphology.

Published
2011
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22. C3 polymorphism and NADH diaphorase types in Sardinia (Italy).

Author

Floris Masala R, Mameli GE, Succa V, and Vona G

Subjects
Alleles, Ethnicity, Gene Frequency, Humans, Italy, Polymorphism, Genetic, Complement C3 genetics, Dihydrolipoamide Dehydrogenase genetics
Abstract

C3 and DIA1 types were studied in Sardinians from four provinces. C3 showed a heterogeneous distribution in the four subsamples and C3*F gene varied between 0.235 (Province of Sassari) and 0.154 (Province of Oristano). No rare types were found in Sardinia in contrast to mainland Italy. There are significant differences compared with some Italian populations on the mainland. DIA1*2 allele varies between 0.0026 (Province of Cagliari) and 0.0157 (Province of Nuoro). Also DIA1 showed a heterogenous distribution.

Published
1990

23. Gc and C3 polymorphisms in South Sardinia.

Author

Floris-Masala R, Gruppioni G, Lunesu M, Mameli GE, Porcella P, Ristaldi MS, Succa V, and Vona G

Subjects
Gene Frequency, Humans, Italy, Polymorphism, Genetic, Complement C3 genetics, Vitamin D-Binding Protein genetics
Abstract

The distribution of phenotypes and gene frequencies of the group-specific component (Gc) and C3 complement were studied in South Sardinia. The gene frequencies were: Gc1 = 0.7346; C3F = 0.1963.

Published
1987
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24. Evaluation of dopaminergic tone in hyperprolactinemia. III. Thyroid-stimulating hormone response to metoclopramide in differential diagnosis and postoperative follow-up of prolactinoma patients.

Author

De Marinis L, Mancini A, Minnielli S, Masala R, Anile C, Maira G, and Barbarino A

Subjects
Adenoma metabolism, Adenoma surgery, Adolescent, Adult, Diagnosis, Differential, Empty Sella Syndrome blood, Female, Humans, Pituitary Neoplasms metabolism, Pituitary Neoplasms surgery, Postoperative Period, Postpartum Period, Pregnancy, Prognosis, Prolactin metabolism, Adenoma diagnosis, Hyperprolactinemia etiology, Metoclopramide, Pituitary Neoplasms diagnosis, Thyrotropin blood
Abstract

Recently, it has been shown that patients with a PRL-secreting pituitary adenoma have a greater thyroid stimulating hormone (TSH) release after dopamine (DA)-receptor blockade than normal subjects. We have compared the TSH and PRL responses to metoclopramide (MCP) in normal and postpartum lactating women with those in 28 patients with hyperprolactinemia of different origin. Patients with a PRL-secreting pituitary adenoma were also tested after transsphenoidal removal of the tumor in order to establish the prognostic value of this test in such patients. Following MCP administration, percent increases in plasma PRL levels were greater in normal female subjects than postpartum lactating women. Plasma TSH levels did not increase in postpartum women and had a modest increment in normal subjects. In patients with hypothalamic tumors and empty sella syndrome plasma PRL and TSH levels showed modest or no increases after MCP administration. In ten patients harboring a microprolactinoma, plasma TSH levels showed an exaggerated increment after DA-receptor blockade. Postoperatively, despite normal or borderline PRL levels in the immediate postoperative period, a TSH response to MCP was present (in five patients one to two weeks after the operation, and in five patients one to three years after the operation), suggesting an increased DA activity even in the absence of hyperprolactinemia. In conclusion, the TSH test can easily detect increased DA-activity in patients with a microprolactinoma both preoperatively and postoperatively. It is possible that some patients with increased DA-activity in presence of normal PRL levels and normal PRL responsiveness to stimulation will experience a recurrence of hyperprolactinemia.(ABSTRACT TRUNCATED AT 250 WORDS)

Published
1985
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26. [Congenital pseudoarthrosis of the clavicle].

Author

Pantano LC, Grenga E, Masala R, and Morandini S

Subjects
Diagnosis, Differential, Humans, Infant, Male, Pseudarthrosis diagnosis, Pseudarthrosis pathology, Clavicle, Pseudarthrosis congenital
Abstract

A case of congenital pseudarthrosis of the clavicle is presented. Congenital pseudarthrosis of the clavicle is a rare entity that has poorly been documented in the pediatric literature. The etiology and pathogenesis still remain obscure. The clinical and radiological appearances are characteristic. Differential diagnosis lies between postpartum fracture, posttraumatic pseudarthrosis, cleidocranial dysostosis and neurofibromatosis.

Published
1988

27. AK, PGM1 and 6PGD polymorphisms in Central Sardinia.

Author

Masala RF, Lunesu M, Ristaldi MS, Succa V, and Vona G

Subjects
Alleles, Gene Frequency, Humans, Italy, Adenylate Kinase genetics, Glucosephosphate Dehydrogenase genetics, Phosphoglucomutase genetics, Phosphotransferases genetics, Polymorphism, Genetic
Abstract

Adenylate kinase (AK), phosphoglucomutase (PGM1) and 6-phosphogluconate dehydrogenase (6PGD) polymorphisms were investigated in a sample of individuals from Central Sardinia. The gene frequencies were: AK1 = 0.973, PGM1(1) = 0.842 and PGDA = 0.969. The frequencies were compared with those of other Italian populations.

Published
1988
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28. AcP and EsD polymorphisms in South Sardinia.

Author

Floris Masala R, Gruppioni G, Mameli GE, Porcella P, and Vona G

Subjects
Carboxylic Ester Hydrolases blood, Gene Frequency, Humans, Italy, Phenotype, Carboxylesterase, Carboxylic Ester Hydrolases genetics, Polymorphism, Genetic
Abstract

A sample of the South Sardinia population was studied with respect to acid phosphatase (AcP) and esterase D (EsD) enzymes. The gene frequencies were: AcPA = 0.326, AcPB = 0.607, AcPC = 0.067 and EsD1 = 0.883. The results were compared with those of other Italian populations.

Published
1986
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30. Letter: Drug-induced asthma.

Author

Bartoli E, Faedda in Masala R, and Chiandussi L

Subjects
Aspirin adverse effects, Dipyrone therapeutic use, Drug Interactions, Female, Humans, Joint Diseases drug therapy, Middle Aged, Aminopyrine analogs & derivatives, Asthma chemically induced, Dipyrone adverse effects
Published
1976
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