27 results on '"Masako Nakata"'
Search Results
2. Prevalence and risk factors of silent obstructive sleep apnea in patients with dentofacial deformities
- Author
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Rei Jokaji, Kazuhiro Ooi, Sayuri Takamichi, Yusuke Nakade, Shuichi Kawashiri, Kazuo Kasahara, and Masako Nakata
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stomatognathic system ,nervous system diseases ,respiratory tract diseases - Abstract
Objective Prevalence of silent obstructive sleep apnea (OSA) in patients with dentofacial deformities is unknown, although OSA is severe risk of airway obstruction in perioperative orthognathic surgery or complication after surgery. The aim of this study was to investigate prevalence and risk factors of silent OSA in patients with dentofacial deformities. Methods We analyzed 72 patients (24 male, 48 female) with dentofacial deformities without previous OSA symptoms. Polysomnography was performed before orthognathic surgery. Prevalence and risk factors of silent OSA were statistically analyzed as related to Apnea hypopnea index (AHI). Results Mean AHI was 1.6 (range: 0-12.1) /h. Three patients of 72 patients (4.1%) were diagnosed silent OSA. AHI during REM sleep phase 3.7 (0-32.3) was higher than AHI during NREM sleep phase 1.0 (0-9.7). AHI of male patients was higher than that of female. AHI was increased according to high BMI. AHI was higher in deep bite than open bite, edge to edge bite and nomal bite. AHI of mandibular asymmetry cases were higher than that of symmetry cases. Conclusions The prevalence of silent OSA was 4.1%. Obesity, male, deep bite, mandibular asymmetry and REM sleep phase were risk factors of silent OSA.
- Published
- 2021
3. Factors related to oxygen desaturation index during sleep 7 days after bilateral sagittal splitting ramus osteotomy in patients without previous obstructive sleep apnea
- Author
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Kazuo Kasahara, Masako Nakata, Yutaka Kobayashi, Shuichi Kawashiri, Sayuri Takamichi, Kazuhiro Ooi, Kentaro Ide, and Rei Jokaji
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Male ,medicine.medical_treatment ,Overjet ,Polysomnography ,Osteotomy, Sagittal Split Ramus ,Orthognathic surgery ,Osteotomy ,REM rebound ,03 medical and health sciences ,0302 clinical medicine ,Medicine ,Humans ,030223 otorhinolaryngology ,Sleep Apnea, Obstructive ,medicine.diagnostic_test ,business.industry ,030206 dentistry ,Perioperative ,medicine.disease ,nervous system diseases ,Obstructive sleep apnea ,Oxygen ,Otorhinolaryngology ,Anesthesia ,Oral and maxillofacial surgery ,Surgery ,Female ,Oral Surgery ,business ,Sleep - Abstract
The incidence of obstructive sleep apnea (OSA) immediately after surgery in patients with dentofacial deformities without previous OSA remains unknown. We aimed to perioperatively evaluate factors associated with oxygen desaturation index (ODI) during sleep, 7 days after bilateral splitting ramus osteotomy (BSSRO) in patients without previous OSA. Fifty-one patients (15 males, 36 females) with dentofacial deformities, scheduled to undergo BSSRO, were included. Polysomnography was performed before orthognathic surgery. Perioperative OSA was evaluated with peripheral arterial tonometry on the day of surgery and 1, 2, 3, 4, and 7 days postoperatively. Rapid eye movement (REM) sleep periods and the ODI were measured. Factors associated with perioperative ODI after surgery were statistically analyzed. REM sleep periods were significantly decreased on the day of surgery and significantly increased at 4 and 7 days postoperatively, compared to the preoperative period. ODI increased on the day of surgery, decreased after 1 day, and increased again at 4 and 7 days postoperatively. ODI on the day of surgery was significantly increased due to increased preoperative ODI, overjet, and SN-MP angle and decreased SNA and SNB angle. ODI at 7 days postoperatively was significantly increased due to increased REM sleep periods and decreased SN-MP and gonial angle. ODI was increased in response to REM sleep periods 7 days after BSSO. Airway management in patients with dentofacial deformity should be given more attention by preoperative assessment for OSA, even in the absence of previous OSA, until 7 days postoperatively due to REM rebound.
- Published
- 2020
4. [Functional Residual Capacity Measurement Based on Lung Structure Model Analysis Using the Helium Gas Dilution Technique]
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Hiroyasu, Oe, Yusuke, Nakade, Masako, Nakata, Yuko, Nanbu, Mikio, Nagahara, and Mika, Mori
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Adult ,Male ,Functional Residual Capacity ,Respiration ,Humans ,Indicator Dilution Techniques ,Female ,Middle Aged ,Lung Volume Measurements ,Helium ,Lung ,Aged ,Respiratory Function Tests - Abstract
In the helium gas dilution method, functional residual capacity (FRC) is calculated from a helium concentra- tion equilibrium curve. In this study, we analyzed the helium concentration equilibrium curves of healthy patients, clarified the determinants of the equilibrium concentration, and studied the effects of an uneven lung distribution. We collected data from 200 patients (92 males and 108 females) whose FRC values had been measured at our institution over the past 6 years. Their FRC values ranged from 80% to 120%, and theit other pulmo- nary function values were within the normal range. In the compartmental model analysis, we discovered that the helium concentration equilibrium curve was composed of one compartment, and that it did not have a polyphasic structure. Each 0.25-minute (15-second) segment of the helium concentration equilibrium curve obtained from the patients was evaluated using univariate and multivariate regression analyses. The helium concentration equilibrium curve decreased exponentially over the time course of the analysis, and the multiple correlation coefficient for the relationship between the 0.25-minute to 0.75-minute segments and the 1.00-minute to 1.50-minute segments in the final model was 0.949. Finally, we examined the influence of an uneven peripheral lung distribution. A model based on the con- centration change seen between the initial and middle periods during at rest ventilation indicated that the latter parameter was not affected by the ventilation volume of the peripheral lung. [Original].
- Published
- 2019
5. Reversibility of the Pulmonary Function Based on the Partial Flow-volume Curve Predicts the Efficacy of Bronchodilator Therapy for Treating Chronic Cough
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Yuko Nanbu, Hiroyasu Oe, Hiroshi Horita, Masako Nakata, Takashi Wada, Noriyuki Ohkura, Yusuke Nakade, Yoshio Sakai, and Masaki Fujimura
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Adult ,Hypersensitivity, Immediate ,Male ,Agonist ,Visual analogue scale ,medicine.drug_class ,Vital Capacity ,pulmonary function tests ,Pulmonary function testing ,Young Adult ,chronic nonproductive cough ,Forced Expiratory Volume ,Bronchodilator ,Internal Medicine ,medicine ,Humans ,cough variant asthma ,Adrenergic beta-2 Receptor Agonists ,Cough variant asthma ,Aged ,Aged, 80 and over ,business.industry ,General Medicine ,Middle Aged ,Volume Curve ,Asthma ,Bronchodilator Agents ,Respiratory Function Tests ,respiratory tract diseases ,Chronic cough ,Treatment Outcome ,Cough ,atopic cough ,Anesthesia ,Chronic Disease ,Female ,Bronchoconstriction ,medicine.symptom ,Pulmonary Ventilation ,business - Abstract
Objective Partial expiratory flow-volume curves have the potential to detect mild bronchoconstriction be- cause they are not affected by the modulatory effects of deep inspiration. The aim of this study was to inves- tigate the relationship between the efficacy of bronchodilator therapy (BDT) in treating the cough and to as- sess the increase in the expiratory flow of the partial flow-volume curve at 40% above the residual volume level (PEF40) caused by treatment with a short-acting beta-2 agonist (SABA) in patients with chronic nonpro- ductive cough. Methods We measured the reversibility of PEF40 caused by a SABA in 42 patients with chronic nonproduc- tive cough at visit 1 (day 0). The patients received BDT for six days. The visual analogue scale (VAS) was used to assess the efficacy of BDT in treating coughing at visit 2 (day 7) (0 mm, 'no cough;' 100 mm, 'no change in coughing'). Results Reversibility of the PEF40 was correlated (r=0.690, p
- Published
- 2013
6. [Study of Somatosensory Event-Related Potential in Mood Disorder]
- Author
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Yuko, Nanbu, Masako, Nakata, Tatsuya, Nagasawa, Hiroyasu, Ohe, Mikio, Nagahara, Yoshio, Sakai, Yoshio, Minabe, and Takashi, Wada
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Adult ,Male ,Mood Disorders ,Humans ,Electroencephalography ,Female ,Evoked Potentials - Abstract
There have been a number of inconsistent previous reports indicating that mood disorder patients are relatively sensitive or conversely insensitive to physical pain. However, there have been few such studies examining pain using neurophysiological techniques. The present study was performed to investigate the differences in tactile sense recognition between mood disorder patients and control subjects using a tactile sense recognition P300 measuring system. Tactile stimuli were delivered to the index finger as frequent stimuli and to the ring finger as infrequent stimuli. Subjects were requested to press a button promptly and accurately in response to infrequent stimuli. N140 and P300 were measured in the event-related potential to infrequent stimulus paradigm. The subjects evaluated stimuli on a visual analog scale (VAS). The amplitudes of P300 were smaller for the mood disorder patients than for control subjects. The VAS scores of mood disorder patients were significantly higher than those of control subjects. In mood disorder patients, the amplitude of P300 was negatively correlated with the HAM-D score. These results suggest dysfunction of tactile sense recognition in mood disorder patients. In addition, the amplitude of P300 may be useful as a biological marker for psychological conditions in mood disorder patients.
- Published
- 2016
7. Evaluation of obstructive sleep apnoea using peripheral arterial tonometry during perioperative period after removal of impacted third molar with dentofacial deformity in general anaesthesia
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Kazuo Kasahara, Shuichi Kawashiri, Hiroyuki Nakamura, Masako Nakata, Yutaka Kobayashi, Sayuri Takamichi, Kazuhiro Ooi, Natsuyo Noguchi, K. Ide, K. Katoh, and Rei Jokaji
- Subjects
Molar ,medicine.medical_specialty ,business.industry ,Arterial tonometry ,Perioperative ,Sleep in non-human animals ,Peripheral ,Surgery ,Dentofacial Deformity ,Otorhinolaryngology ,Anesthesia ,medicine ,General anaesthesia ,Oral Surgery ,business - Published
- 2017
8. Perioperative evaluation and management of obstructive sleep apnoea after mandibular setback by sagittal split ramus osteotomy
- Author
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Kazuhiro Ooi, M. Ishimiya, Hiroko Kitahara, Hiroyuki Nakamura, Kazuo Kasahara, Natsuyo Noguchi, Sayuri Takamichi, K. Ide, Masako Nakata, Rei Jokaji, Yutaka Kobayashi, Shuichi Kawashiri, and K. Katoh
- Subjects
medicine.medical_specialty ,Otorhinolaryngology ,Sagittal Split Ramus Osteotomy ,business.industry ,medicine ,Surgery ,Perioperative ,Oral Surgery ,business ,Sleep in non-human animals ,Setback - Published
- 2017
9. Evaluation of obstructive sleep apnoea and sleep quality in patients with skeletal class III malocclusion
- Author
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Sayuri Takamichi, Shuichi Kawashiri, Yutaka Kobayashi, Masako Nakata, Hiroyuki Nakamura, Kazuo Kasahara, K. Ide, Kazuhiro Ooi, Rei Jokaji, Natsuyo Noguchi, and K. Katoh
- Subjects
medicine.medical_specialty ,Sleep quality ,business.industry ,Skeletal class ,medicine.disease ,Sleep in non-human animals ,Otorhinolaryngology ,medicine ,Physical therapy ,Surgery ,In patient ,Oral Surgery ,Malocclusion ,business - Published
- 2017
10. Prolonged Nonpulsatile Left Heart Bypass Diminishes Vascular Contractility
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Eisuke Tatsumi, Masako Nakata, Tomohiro Nishinaka, Yoshiyuki Taenaka, Hisateru Takano, and T. Nishimura
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Heart Bypass, Left ,medicine.medical_specialty ,Vasodilator Agents ,medicine.medical_treatment ,030232 urology & nephrology ,Biomedical Engineering ,Pulsatile flow ,Medicine (miscellaneous) ,Bioengineering ,030204 cardiovascular system & hematology ,Biomaterials ,Contractility ,Norepinephrine (medication) ,Nitroglycerin ,Norepinephrine ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Animals ,Vasoconstrictor Agents ,Heart bypass ,Aortic Pulse Pressure ,Pulse ,Aorta ,Vascular contractility ,business.industry ,Goats ,Hemodynamics ,General Medicine ,medicine.anatomical_structure ,Vasoconstriction ,Pulsatile Flow ,Ventricular assist device ,Cardiology ,Vascular resistance ,Vascular Resistance ,Heart-Assist Devices ,business ,Blood Flow Velocity ,medicine.drug - Abstract
We investigated possible functional changes in the vascular system accompanying the morphological change in prolonged nonpulsatile left heart bypass (LHB). Three adult goats underwent pulsatile LHB. Two weeks postoperatively, the pulsatile ventricular assist device was replaced with a centrifugal pump and nonpulsatile LHB was subsequently conducted for 4 weeks. The mean aortic pulse pressure was 39 and 16 mmHg during the pulsatile and nonpulsatile LHB, respectively. Systemic vascular resistance (SVR) and plasma norepinephrine levels were measured at the end of pulsatile LHB (PUL), and at the end of 1st, 2nd, 3rd, and 4th week of nonpulsatile LHB (NP1w, NP2w, NP3w, NP4w, respectively). At each point, 50 μg/kg nitroglycerin and 1μg/kg norepinephrine were injected and the minimal and maximal values of SVR after injection were calculated as parameters reflecting the vascular tonus and contractility. The SVR and plasma nor epinephrine level did not significantly change during the entire course (SVR: 1106, 895, 982, 920, and 938 dyne·sec·cm−5; norepinephrine level: 0.3, 0.2, 0.1, 0.2, and 0.1 ng/ml; at PUL, NP1w, NP2w, NP3w, and NP4w, respectively). The minimal value of SVR after nitroglycerin injection remained unchanged, indicating that vascular tonus was stable during the entire course (618, 687, 623, 560, 653 dyne·sec·cm−5, respectively). In contrast, the maximal value of SVR after norepinephrine injection at NP3w and NP4w (1695 and 1759 yne·sec·cm−5) became significantly reduced compared to that at PUL (2346 dyne·sec·cm−5). These results indicated that prolonged nonpulsatile left heart bypass did not affect the vascular tonus, but significantly diminished the vascular contractility.
- Published
- 1999
11. Image Measurement of Wall Shear Stress Based on Paint Erosion
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Kenkichi Ohba, Masako Nakata, Toru Masuzawa, and Yoshiyuki Taenaka
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Shear stress ,Erosion ,Geotechnical engineering ,Geology ,Image measurement - Published
- 1997
12. Drag and Flow Field around Elasto-Flexible Cylinder in Uniform Flow
- Author
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Kenkichi Ohba and Masako Nakata
- Subjects
Physics ,Drag coefficient ,Lift-induced drag ,Mechanical Engineering ,Mechanics ,Industrial and Manufacturing Engineering ,Physics::Fluid Dynamics ,Mechanics of Materials ,Drag ,Parasitic drag ,Wave drag ,Aerodynamic drag ,Drag divergence Mach number ,Potential flow around a circular cylinder - Abstract
The purpose of this experiment is to clarify the mechanism of drag reduction in the natural swimming of fish, whales and dolphins. It is well known that the change in their shape and the local deformation of their skin contribute to drag reduction, especially in the case of dolphins. Therefore, in order to understand the interaction between a deformable surface and the local flow pattern, RFFRC (rigid front flexible rear cylinder) models of a simplified marine animal were studied in a water tunnel. The laser light sheet method was used to visualize the flow field around the models. The vortex pair shedding period from the models, the deformation of the models' cross-sectional form and models' drag were measured simultaneously. The following results were obtained. For some types of RFFRC which could be deformed easily in response to a change in the local flow pattern with vortex shedding, the increase in flow velocity in the wake was observed. In the case the St number was about 20% higher than that of a rigid cylinder. Although, the drag that some types of RFFRC had was higher than that of the rigid one. However, the other types of RFFRC which could not quickly deform show no difference in St number, whereas the mean drag of this type was about 20% lower and the time variation of the drag became smaller than that of the rigid cylinder.
- Published
- 1997
13. Visualization of Flow Field around Elasto-Flexible Cylinder
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Masako Nakata and Kenkichi Ohba
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Engineering ,business.industry ,Front (oceanography) ,Mechanics ,Wake ,Deformation (meteorology) ,Vortex ,Physics::Fluid Dynamics ,Optics ,Water tunnel ,Drag ,Cylinder ,Potential flow around a circular cylinder ,business - Abstract
The purpose of this study is to clarify the mechanism of decreasing the drag in natural swimming of fish, whale and dolphin. A cylinder which has Elasto-flexible surface simplified marine creature was placed in a water tunnel, and using Laser Light Sheet method to visualize flow field around the model, vortex pair shedding period from the model, deformation of its cross-sectional form and hydrodynamical drag of the model were simultaneously measured. As a result, the following were found: the rigid front flexible rear cylinder model has showed about 20% higher St number than rigid cylinder model. The local deformation of the surface changed local flow pattern and wake due to some interaction between flexible surface and vortex. Time variation of the drag of the Rigid Front Flexible Rear Cylinder (RFFRC) became smaller than rigid one.
- Published
- 1995
14. The optimal immersion time for the hot pack and the change in the surface temperature of human skin during the application of the hot pack
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Masako Nakata, Hideki Shinohara, Masaki Yoshida, and Noriaki Ichihashi
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Materials science ,Hot pack ,Immersion (virtual reality) ,Composite material - Abstract
ホットパックは痛みを除去し筋緊張を和らげるために最も一般的に用いられる温熱療法である。しかしながら、臨床上では全く経験的に使用されており、それを再利用するのに適正な浸潰時間についての報告はない。本研究の目的はホットパックの適正なハイドロコレーター内浸潰時間を見いだすことにある。本研究のために、一日中浸されたホットパックを背部に30分間適用した。内ひとつのホットパックは再びハイドロコレーター内に浸され、その申心温度を測定した。さらに、他のホットパックはそれぞれ5、10、15そして20分の浸潰時間でハイドロコレーター内に浸され、その後、それぞれを背部に置き、直下の皮膚表面の温度を測定した。
- Published
- 1990
15. Augmentative effect of pulsatility on the wall shear stress in tube flow
- Author
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Takashi Nishimura, Kenkichi Ohba, Eisuke Tatsumi, Tomonori Tsukiya, Tomohiro Nishinaka, Masako Nakata, Toru Masuzawa, Hisateru Takano, and Yoshiyuki Taenaka
- Subjects
medicine.medical_specialty ,Materials science ,Flow (psychology) ,Biomedical Engineering ,Pulsatile flow ,Medicine (miscellaneous) ,Bioengineering ,Biomaterials ,medicine ,Shear stress ,Mean flow ,Pulse ,Pulse (signal processing) ,Models, Cardiovascular ,General Medicine ,Dyne ,Centrifugal pump ,Volumetric flow rate ,Surgery ,Models, Structural ,Pulsatile Flow ,cardiovascular system ,Blood Vessels ,Rheology ,Blood Flow Velocity ,circulatory and respiratory physiology ,Biomedical engineering - Abstract
Wall shear stress (WSS) has been considered to play an important role in the physiological and metabolic functions of the vascular endothelial cells. We investigated the effects of the pulse rate and the maximum flow rate on the WSS to clarify the influence of pulsatility. Water was perfused in a 1/2 inch transparent straight cylinder with a nonpulsatile centrifugal pump and a pulsatile pneumatic ventricular assist device (VAD). In nonpulsatile flow (NF), the flow rate was changed 1 to 6 L/min by 1 L/min increments to obtain standard values of WSS at each flow rate. In pulsatile flow (PF), the pulse rate was controlled at 40, 60, and 80 bpm, and the maximum flow rate was varied from 3.3 to 12.0 L/min while the mean flow rate was kept at 3 L/min. The WSS was estimated from the velocity profile at measuring points using the laser illuminated fluorescence method. In NF, the WSS was 12.0 dyne/cm2 at 3 L/min and 33.0 dyne/cm2 at 6 L/min. In PF, the pulse rate change with the same mean, and the maximum flow rate did not affect WSS. On the other hand, the increase in the maximum flow rate at the constant mean flow rate of 3 L/min augmented the mean WSS from 13.1 to 32.9 dyne/cm2. We concluded that the maximum flow rate exerted a substantial augmentative effect on WSS, and the maximum flow rate was a dominant factor of pulsatility in this effect.
- Published
- 1999
16. Diminished vasoconstrictive function caused by long-term nonpulsatile left heart bypass
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Hisateru Takano, Masako Nakata, Tomohiro Nishinaka, Toru Masuzawa, Takashi Nishimura, Yoshiyuki Taenaka, and Eisuke Tatsumi
- Subjects
Heart Bypass, Left ,medicine.medical_specialty ,Central Venous Pressure ,Biomedical Engineering ,Pulsatile flow ,Medicine (miscellaneous) ,Bioengineering ,Blood Pressure ,Biomaterials ,Norepinephrine (medication) ,Norepinephrine ,Internal medicine ,medicine ,Animals ,Heart bypass ,Aortic Pulse Pressure ,Aorta ,business.industry ,Goats ,Central venous pressure ,General Medicine ,Blood pressure ,medicine.anatomical_structure ,Vasoconstriction ,Vascular resistance ,Cardiology ,Vascular Resistance ,medicine.symptom ,business ,medicine.drug - Abstract
We investigated the functional changes of the systemic vascular system due to prolonged nonpulsatile left heart bypass (NPLHB). Three adult goats underwent pulsatile left heart bypass (PLHB). Two weeks later the PLHB was changed to the NPLHB, which was conducted for 4 weeks. The aortic pulse pressure was 39 and 16 mm Hg during the PLHB and NPLHB, respectively. Systemic vascular resistance (SVR) and the plasma norepinephrine level were measured at the end of PLHB (PUL), and in the 1st, 2nd, 3rd, and 4th weeks of NPLHB (NP1w, NP2w, NP3w, and NP4w). At each point, 1 microg/kg norepinephrine was injected, and the elevation of the SVR (deltaSVR) was calculated. The SVR and the plasma norepinephrine level did not change significantly during the entire course. However, deltaSVR decreased during NPLHB and became significantly lower at NP3w and NP4w than that at PUL (NP3w: 839 +/- 164, NP4w: 746 +/- 268, and PUL: 1,239 +/- 324 dyne x s x cm(-5)). These results strongly indicated that prolonged NPLHB significantly diminished the constrictive function of the vascular system.
- Published
- 1999
17. Development of an ultracompact integrated heart-lung assist device
- Author
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Tomonori Tsukiya, Takashi Nishimura, Yukihide Kakuta, Yoshiyuki Taenaka, Tomohiro Nishinaka, Takano H, Masako Nakata, and Eisuke Tatsumi
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Materials science ,Time Factors ,Surface Properties ,Biomedical Engineering ,Medicine (miscellaneous) ,chemistry.chemical_element ,Bioengineering ,Blood Pressure ,Heart-Lung Machine ,Oxygen ,Artificial lung ,Biomaterials ,Coated Materials, Biocompatible ,medicine ,Animals ,Oxygenators, Membrane ,Lung ,Heparin ,Pulmonary Gas Exchange ,Goats ,Anticoagulants ,Membranes, Artificial ,Thrombosis ,General Medicine ,Blood flow ,Equipment Design ,Carbon Dioxide ,Centrifugal pump ,Membrane ,medicine.anatomical_structure ,Volume (thermodynamics) ,chemistry ,Heart-Assist Devices ,medicine.drug ,Biomedical engineering - Abstract
A novel integrated heart-lung assist device has been developed as a simple to use portable cardiopulmonary support system. The device comprises a centrifugal pump and an artificial lung, which is located around the pump, in an all in one system. The special membrane employed precludes plasma breakthrough in protracted use and enables preprimed setup. Test lungs consisting of the same membrane preserved gas exchange function well after 3 months of preprimed storage. The entire blood contacting surface is treated with covalent heparin bonding to impart good antithrombogenicity. Heparin bonded test lungs could be continuously perfused without systemic anticoagulation as long as 36 days in a venoarterial bypass chronic animal study using goats. The prototype device (diameter, 126 mm; height, 59 mm; membrane area, 0.85 m2; priming volume, 180 ml) demonstrated 9 L/min pump output at a 400 mm Hg pressure head and 180 ml/min oxygen and 110 ml/min carbon dioxide transfer rates at 5 L/min blood flow. We conclude that this device has potential to be the next generation cardiopulmonary support system.
- Published
- 1999
18. Cardiac autonomic nervous function during long-term nonpulsatile left heart bypass
- Author
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Takashi Nishimura, Tomohiro Nishinaka, Toru Masuzawa, Hitoshi Koyanagi, Hisateru Takano, Masako Nakata, Yoshiyuki Taenaka, and Eisuke Tatsumi
- Subjects
Heart Bypass, Left ,Sympathetic Nervous System ,Time Factors ,medicine.medical_treatment ,Biomedical Engineering ,Pulsatile flow ,Medicine (miscellaneous) ,Bioengineering ,Blood Pressure ,Low frequency band ,Autonomic Nervous System ,Biomaterials ,Heart Conduction System ,Heart Rate ,Parasympathetic Nervous System ,Autonomic nervous function ,Medicine ,Heart rate variability ,Animals ,Spectral analysis ,Heart bypass ,Longitudinal Studies ,Mammary Arteries ,Aorta ,Analysis of Variance ,business.industry ,Goats ,Signal Processing, Computer-Assisted ,General Medicine ,Anesthesia ,Ventricular assist device ,Pulsatile Flow ,Blood Circulation ,business - Abstract
We investigated the changes in cardiac autonomic nervous activities during long-term nonpulsatile left heart bypass (NLHB) by analyzing heart rate variability. A pulsatile ventricular assist device was installed in 3 goats, and pulsatile left heart bypass (PLHB) was conducted for 2 weeks. Then, NLHB was maintained for the following 4 weeks. The segmental data of the R-R intervals (R-Rs) was analyzed by maximum entropy spectral analysis. Changes in evaluated parameters from the last week of PLHB to the 4th week of NLHB were as follows: the mean R-Rs increased from 511 ms to 692 ms; the coefficient of variation of R-R increased from 10.2 to 14.1%; the power of the low frequency band (LF) increased from 747 ms2 to 2,855 ms2; the power of the high frequency band (HF) increased from 512 ms2 to 1,270 ms2; and the ratio of LF to HF increased from 2.6 to 6.5. These results indicated that the cardiac autonomic nervous activity, both sympathetic and parasympathetic, increased during long-term NLHB.
- Published
- 1999
19. In vivo evaluation of the national cardiovascular center electrohydraulic total artificial heart
- Author
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Bin Zhang, Masako Nakata, Kinji Tsukahara, Seiko Endo, Makoto Nakamura, Toru Masuzawa, Tomohiro Nishinaka, Yukihide Kakuta, Eisuke Tatsumi, Tomomichi Nakamura, Hisateru Takano, Takashi Nishimura, Yoshiyuki Taenaka, and Katsuya Tsuchimoto
- Subjects
medicine.medical_specialty ,Biomedical Engineering ,Medicine (miscellaneous) ,Bioengineering ,Heart, Artificial ,Prosthesis Design ,law.invention ,Body Temperature ,Biomaterials ,law ,Artificial heart ,medicine ,Animals ,Thrombus ,Cardiovascular centre ,business.industry ,Hemodynamics ,General Medicine ,medicine.disease ,Surgery ,Diaphragm (structural system) ,Blood pump ,Stenosis ,Great vessels ,Evaluation Studies as Topic ,Circulatory system ,Cattle ,Equipment Failure ,Female ,business ,Blood Chemical Analysis - Abstract
We have been developing an electrohydraulic total artificial heart system. The system comprises an intrathoracic pumping unit composed of diaphragm type ellipsoidal blood pumps and an energy converter in addition to an electronics unit. The in vivo performance of the pumping unit was evaluated in a series of animal implantations with 3 calves weighing 62-85 kg. An interatrial shunt 4.5 mm in diameter was made in the atrial septum to compensate left-right imbalance. Two calves died early postoperatively, one of external controller power failure and the other of interatrial shunt stenosis due to thrombus formation. One calf, however, survived over 10 days under stable circulatory conditions. No abnormality was found in the oxygen metabolic condition or in major organ functions. The generation and dissipation of heat from the device was acceptable. This animal died of device malfunction caused by energy converter bearing breakdown. The device demonstrated a good anatomic fit without compromising the great vessels and adjacent tissues. It is concluded that the pumping unit has a sufficient in vivo basic performance although appropriate countermeasures are to be implemented against the detected problems concerning mechanical durability and interatrial shunt patency.
- Published
- 1999
20. Characterization and optimization of the flow pattern inside a diaphragm blood pump based on flow visualization techniques
- Author
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Toru Masuzawa, Masako Nakata, Kenkichi Ohba, Hisateru Takano, Takashi Nishimura, Yoshiyuki Taenaka, Katsuya Tsuchimoto, Tomonori Tsukiya, and Eisuke Tatsumi
- Subjects
Flow visualization ,Materials science ,Flow (psychology) ,Biomedical Engineering ,Biophysics ,Washout ,Bioengineering ,Diaphragm (mechanical device) ,General Medicine ,Inflow ,Mechanics ,Heart, Artificial ,Prosthesis Design ,Biomaterials ,Blood pump ,Regional Blood Flow ,Outflow ,Body orifice - Abstract
We applied two different flow visualization techniques to obtain detailed information on the inside flow of the diaphragm blood pump of our electrohydraulic total artificial heart system to determine the optimum washout effect that would result in better antithrombogenicity. Major orifice directions of the inflow and outflow Bjork-Shiley valves of the left blood pump were independently changed to create 17 varied patterns. The character and velocity of the main flow at the diaphragm-housing junction were acquired using a laser light sheet method with polyethylene tracers. Wall shear flow, a major factor governing washout in the blood pump, was estimated by a newly developed paint erosion method. In this method, quantitative evaluation for an index of washout effect was made by calculating the residual ratio of the paint on the blood pump inner surface at 30 sec of pumping. When a single circular flow was consistently observed by the laser light sheet method, the paint residual ratio become low, indicating washout was relatively good. At the lowest paint residual ratio, the center of the circular flow observed by the laser light sheet method was located at the geometric center of the blood chamber. In conclusion, the flow pattern inside the blood pump could be characterized by combined use of these two flow visualization techniques, and the significant role of circular flow in better washout was clarified.
- Published
- 1998
21. Prolonged nonpulsatile left heart bypass with reduced systemic pulse pressure causes morphological changes in the aortic wall
- Author
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Hisateru Takano, Takaichi S, Yoshiyuki Taenaka, Toru Masuzawa, Seiko Endo, Takashi Nishimura, Eisuke Tatsumi, Yoshinari Wakisaka, Yoshiaki Takewa, Takeshi Nakatani, Masako Nakata, and Makoto Nakamura
- Subjects
Heart Bypass, Left ,endocrine system ,medicine.medical_specialty ,Biomedical Engineering ,Pulsatile flow ,Medicine (miscellaneous) ,Bioengineering ,Aorta, Thoracic ,Cell Count ,Muscle, Smooth, Vascular ,Biomaterials ,Contractility ,Cell Wall ,Internal medicine ,medicine.artery ,medicine ,Pressure ,Animals ,Heart bypass ,Aorta ,business.industry ,Pulse (signal processing) ,General Medicine ,Pulse pressure ,Aortic wall ,Descending aorta ,Pulsatile Flow ,cardiovascular system ,Cardiology ,Cattle ,business ,Blood Flow Velocity ,Muscle Contraction - Abstract
We investigated the morphological changes in the aorta due to reduced systemic pulse pressure in prolonged nonpulsatile left heart bypass (LHB). Nineteen adult goats were divided into 3 groups, the nonpulsatile group in which nonpulsatile LHB was conducted, the pulsatile group in which pulsatile LHB was conducted, and the control group used as the normal control. The average aortic pulse pressures were 12, 47, and 37 mm Hg, respectively. The descending aorta was subjected to morphological examination. In the nonpulsatile group, the wall was significantly thinner, and the volume ratio of smooth muscle cells (SMCs) was much lower. In terms of the SMC type classification, the proportion of SMCs with low activity and low contractility was higher, and the cell density of the SMCs was increased compared to those in the other groups. These results indicate that prolonged nonpulsatile LHB causes morphological atrophic changes in the aorta.
- Published
- 1998
22. In vitro and in vivo evaluation of a left-right balancing capacity of an interatrial shunt in an electrohydraulic total artificial heart system
- Author
-
Takeshi Nakatani, Toru Masuzawa, Eisuke Tatsumi, Seiko Endo, Yoshiyuki Taenaka, Takashi Ohno, Koki Takiura, Hisateru Takano, Masako Nakata, Yukihide Kakuta, Yoshiaki Takewa, Takashi Nishimura, Young-Sang Sohn, and Makoto Nakamura
- Subjects
medicine.medical_specialty ,Cardiac output ,Biophysics ,Biomedical Engineering ,Bioengineering ,Blood Pressure ,Heart, Artificial ,In Vitro Techniques ,Prosthesis Design ,law.invention ,Biomaterials ,In vivo ,law ,Internal medicine ,Artificial heart ,medicine ,Pericardium ,Animals ,Humans ,Thrombus ,Pressure gradient ,business.industry ,Hemodynamics ,General Medicine ,medicine.disease ,Atrial Function ,Compliance (physiology) ,medicine.anatomical_structure ,Evaluation Studies as Topic ,Interatrial shunt ,Cardiology ,Cattle ,Female ,business ,Blood Flow Velocity ,Biomedical engineering - Abstract
The authors evaluated the basic performance of an interatrial shunt (IAS) made by punching a hole in the atrial septum, in accommodating the left-right imbalance in our electrohydraulic total artificial heart (EHTAH) system. In an in vitro study conducted in a closed mock circuit connected with the EHTAH, the interatrial pressure gradient changed in compliance with the amount of bronchial flow and the size of the IAS. The IAS of 4.4 mm diameter or larger maintained the interatrial pressure gradient within physiologically permissible limits when the amount of bronchial flow was 5% of cardiac output or less. A left-to-right one-way valve made of a piece of pericardium, a possible option in this IAS method, successfully prevented right-to-left reverse shunt flow through the IAS. In a chronic in vivo study using a calf implanted with the EHTAH for 10 days, a 4.5 mm IAS without the one-way valve demonstrated satisfactory dynamic left-right balancing capacity with a stable interatrial pressure gradient of 4 +/- 1 mmHg over a wide range of atrial pressures. No thrombus was found in or around the IAS at autopsy. The authors conclude that the IAS is a simple and promising means of left-right balancing in the EHTAH system.
- Published
- 1997
23. Application of the paint erosion method to evaluation of antithrombogenicity of an artificial heart
- Author
-
Tomonori Tsukiya, Yoshiyuki Taenaka, Masako Nakata, Kenkichi Ohba, Eisuke Tatsumi, and Toru Masuzawa
- Subjects
Materials science ,Flow (psychology) ,Pulsatile flow ,medicine.disease ,Image measurement ,law.invention ,Blood pump ,law ,Artificial heart ,cardiovascular system ,Shear stress ,medicine ,Erosion ,Thrombus ,circulatory and respiratory physiology ,Biomedical engineering - Abstract
We have developed a novel image measurement technique called paint erosion method (PEM) to estimate wall shear stress (WSS). In the PEM, the WSS is estimated from the paint erosion rate obtained by the instantaneous change of light transmission power on the image. In this study, we attempted to depict WSS distribution of the diaphragm-type pulsatile blood pump in our total artificial heart by the PEM, and further compared the obtained WSS distribution with in vivo thrombus deposition area. The average WSS contour map inside the blood pumps were successfully obtained by using the PEM, and in vivo thrombus deposition area coincided with the low WSS of less than 2.7 Pa. We concluded that WSS mapping based on the PEM provides useful information for predicting the preference area of in vivo thrombus formation in a pulsatile blood pump and facilitates improving its antithrombogenicity from the viewpoint of flow dynamics.
- Published
- 1999
24. Increase in Vortex Shedding Frequency from an Elasto-Flexible Cylinder in Uniform Water Flow
- Author
-
Masako Nakata and Kenkichi Ohba
- Subjects
Flexibility (anatomy) ,Materials science ,Water flow ,business.industry ,General Physics and Astronomy ,Mechanics ,Vortex shedding ,Elastic cylinder ,Flow separation ,medicine.anatomical_structure ,Optics ,medicine ,Cylinder ,business - Published
- 1996
25. MAPPING OF DYNAMIC WALL SHEAR STRESS INSIDE DIAPHRAGM-TYPE PULSATILE BLOOD PUMP BY A NOVEL FLOW VISUALIZATION TECHNIQUE AND ITS RELEVANCE TO IN VIVO THROMBUS DEPOSITION
- Author
-
Kenkichi Ohba, Masako Nakata, Tomonori Tsukiya, Yoshiyuki Taenaka, Eisuke Tatsumi, and Hisateru Takano
- Subjects
Flow visualization ,Materials science ,Biomedical Engineering ,Biophysics ,Pulsatile flow ,Bioengineering ,Diaphragm (mechanical device) ,General Medicine ,medicine.disease ,Biomaterials ,Blood pump ,In vivo ,Shear stress ,medicine ,Deposition (phase transition) ,Thrombus ,Biomedical engineering - Published
- 1999
26. IN VITRO AND IN VIVO EVALUATION OF LEFT-RIGHT BALANCING ABILITY OF AN INTERATRIAL SHUNT IN AN ELECTROHYDRAULIC TAH (EHTAH) SYSTEM
- Author
-
Yoshiyuki Taenaka, Tatsuya Nakatani, M Nakamura, Masako Nakata, Hisateru Takano, Young-Sang Sohn, Eisuke Tatsumi, and Toru Masuzawa
- Subjects
Biomaterials ,medicine.medical_specialty ,business.industry ,In vivo ,Biomedical Engineering ,Biophysics ,Interatrial shunt ,Medicine ,Bioengineering ,General Medicine ,business ,In vitro ,Surgery - Published
- 1997
27. Production, Absorption, and Blood Flow Dynamics of Short-Chain Fatty Acids Produced by Fermentation in Piglet Hindgut during the Suckling–Weaning Period
- Author
-
Masako Nakatani, Ryo Inoue, Shozo Tomonaga, Kikuto Fukuta, and Takamitsu Tsukahara
- Subjects
short-chain fatty acid ,hindgut fermentation ,absorption from lumen ,suckling ,weaning ,Nutrition. Foods and food supply ,TX341-641 - Abstract
Luminal short-chain fatty acids (SCFA) are rapidly absorbed from the intestine and subsequently utilized by the host as substrate for metabolic energy production. In pigs, the energy contribution of SCFA is thought to be 30–76%. However, since absorption and blood flow dynamics of SCFA in pigs, particularly during the suckling–weaning period, remain unclear, we aimed to elucidate these phenomena. Thirty-two piglets were used in the present work. Cecal vein blood and digesta, and portal and abdominal vein blood were sampled from suckling (7-, 14-, 21- and 28-day-old) and weaned (weaning at 21 and 28 days of age) piglets. Four piglets from each group were euthanized. SCFA concentrations in blood samples were analyzed by a highly sensitive gas chromatography-mass spectrometry technique. Age at weaning tended to affect SCFA absorption. For example, acetate and propionate concentrations in the cecal vein tended to be higher in piglets weaned at day 21 than at day 28. SCFA concentrations in the abdominal vein tended to differ from those in other veins. Mucosal gene expression analysis suggested that monocarboxylate transporter 1 and occludin were associated in absorption of SCFA from the lumen into the blood of piglets.
- Published
- 2018
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