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動脈硬化症を有する高脂血症患者および実験的高脂血性家兎を中心に, 血漿 Lecithin-Cholesterol Acyltransferase 活性を測定し, 血中脂質濃度との関係から, 高脂血症における本酵素の意義について検討した.本酵素活性は14C-free cholesterol を用いた赤沼らの方法に従って測定したが, 正脂血の動脈硬化症群では 健常群に比して本酵素活性は低下していたが, 高脂血症群では健常群と同様の活性値であった. 血中脂質濃度と本酵素活性との関係を検討したところ, 高脂血および正脂血の動脈硬化症症例では, 本酵素活性と中性脂肪,pre β リポ蛋白百分率および肥満度との間に有意の相関関係がみられた. ラノリン投与による高脂血性家兎でも, 対照家兎に比して, 本酵素活性は有意に亢進していた. 以上の成績から, 本酵素は血中脂質の濃度に適応して, 脂質の担送に重要な機能を果たしているものと考えられる.

The metabolism of orally administered maltitol was investigated and compared with clinical study, especially in two groups, one which exhibited diabetic type and the other non-diabetic type (contained intermediate type) in 50g glucose tolerance test.The following results were obtained. The variation curves of blood sugar, immunoreactive insulin, and non-esterified fatty acids levels effected by 50g maltitol tolerance test in both groups had been extremely lower than those effected by 50g glucose tolerance test.So, it was considered that maltitol per se had been hardly absorbable through intestinal wall, clinically as so with animal study. In the case of concurrent administration of 50g maltitol and 50g glucose, the absorption of glucose was inhibited, resulting in a lower increase of blood sugar level than in the case of an individual administration of 50g glucose.