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1. Epiretinal proliferation embedding combined with internal limiting membrane flap inversion for secondary macular hole: Two case reports

Author

Masaki Fukushima, Tsuyoshi Kato, and Atsushi Hayashi

Subjects
Epiretinal proliferation, Macular hole, Inverted internal limiting membrane flap, Lamellar macular hole, Embedding, Plugging, Ophthalmology, RE1-994
Abstract

Purpose: We describe the cases of two patients for whom we performed an epiretinal proliferation (EP) embedding technique combined with internal limiting membrane (ILM) flap inversion for a full-thickness macular hole (FTMH) with EP. Observations: Patient 1 was a 69-year-old Japanese man with decreased vision in his left eye (20/40). He underwent pars plana vitrectomy (PPV) twice for rhegmatogenous retinal detachment and intraocular lens (IOL) dislocation in his left eye. B-scan optical coherence tomography (OCT) imaging revealed FTMH and EP on the surface of a macular hole (MH). We performed a vitrectomy, EP embedding, and ILM inversion (fill). Patient 2 was a 73-year-old Japanese man with decreased vision in his right eye (20/32). He underwent PPV for vitreous hemorrhage and proliferative diabetic retinopathy in his right eye. B-scan OCT imaging revealed FTMH and EP on the surface of an MH. We performed a vitrectomy, EP embedding, and ILM inversion (cover). Six months post-surgery, the FTMH in both patients had closed completely, and each patient's foveal contour and visual acuity (20/20) had improved. Conclusions and importance: EP embedding combined with ILM flap inversion may be effective for treating secondary MHs with EP.

Published
2023
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2. Creation of X-linked Alport syndrome rat model with Col4a5 deficiency

Author

Masumi Namba, Tomoe Kobayashi, Mayumi Kohno, Takayuki Koyano, Takuo Hirose, Masaki Fukushima, and Makoto Matsuyama

Subjects
Medicine, Science
Abstract

Abstract Alport syndrome is an inherited chronic human kidney disease, characterized by glomerular basement membrane abnormalities. This disease is caused by mutations in COL4A3, COL4A4, or COL4A5 gene. The knockout mice for Col4α3, Col4α4, and Col4α5 are developed and well characterized for the study of Alport syndrome. However, disease progression and effects of pharmacological therapy depend on the genetic variability. This model was reliable only to mouse. In this study, we created a novel Alport syndrome rat model utilizing the rGONAD technology, which generated rat with a deletion of the Col4α5 gene. Col4α5 deficient rats showed hematuria, proteinuria, high levels of BUN, Cre, and then died at 18 to 28 weeks of age (Hemizygous mutant males). Histological and ultrastructural analyses displayed the abnormalities including parietal cell hyperplasia, mesangial sclerosis, and interstitial fibrosis. Then, we demonstrated that α3/α4/α5 (IV) and α5/α5/α6 (IV) chains of type IV collagen disrupted in Col4α5 deficient rats. Thus, Col4α5 mutant rat is a reliable candidate for the Alport syndrome model for underlying the mechanism of kidney diseases and further identifying potential therapeutic targets for human renal diseases.

Published
2021
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4. Successful production of genome-edited rats by the rGONAD method

Author

Tomoe Kobayashi, Masumi Namba, Takayuki Koyano, Masaki Fukushima, Masahiro Sato, Masato Ohtsuka, and Makoto Matsuyama

Subjects
CRISPR/Cas9, i-GONAD, rGONAD, Rat, Knock-out, Knock-in, Biotechnology, TP248.13-248.65
Abstract

Abstract Background Recent progress in development of the CRISPR/Cas9 system has been shown to be an efficient gene-editing technology in various organisms. We recently developed a novel method called Genome-editing via Oviductal Nucleic Acids Delivery (GONAD) in mice; a novel in vivo genome editing system that does not require ex vivo handling of embryos, and this technology is newly developed and renamed as “improved GONAD” (i-GONAD). However, this technology has been limited only to mice. Therefore in this study, we challenge to apply this technology to rats. Results Here, we determine the most suitable condition for in vivo gene delivery towards rat preimplantation embryos using tetramethylrhodamine-labelled dextran, termed as Rat improved GONAD (rGONAD). Then, to investigate whether this method is feasible to generate genome-edited rats by delivery of CRISPR/Cas9 components, the tyrosinase (Tyr) gene was used as a target. Some pups showed albino-colored coat, indicating disruption of wild-type Tyr gene allele. Furthermore, we confirm that rGONAD method can be used to introduce genetic changes in rat genome by the ssODN-based knock-in. Conclusions We first establish the rGONAD method for generating genome-edited rats. We demonstrate high efficiency of the rGONAD method to produce knock-out and knock-in rats, which will facilitate the production of rat genome engineering experiment. The rGONAD method can also be readily applicable in mammals such as guinea pig, hamster, cow, pig, and other mammals.

Published
2018
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12. The Effect of Medical Cooperation in the CKD Patients: 10-Year Multicenter Cohort Study

Author

Yasuhiro Onishi, Haruhito A. Uchida, Yohei Maeshima, Yuka Okuyama, Nozomu Otaka, Haruyo Ujike, Keiko Tanaka, Hidemi Takeuchi, Kenji Tsuji, Masashi Kitagawa, Katsuyuki Tanabe, Hiroshi Morinaga, Masaru Kinomura, Shinji Kitamura, Hitoshi Sugiyama, Kosuke Ota, Keisuke Maruyama, Makoto Hiramatsu, Yoshiyuki Oshiro, Shigeru Morioka, Keiichi Takiue, Kazuyoshi Omori, Masaki Fukushima, Naoyuki Gamou, Hiroshi Hirata, Ryosuke Sato, Hirofumi Makino, and Jun Wada

Subjects
chronic kidney disease (CKD), medical cooperation, patient care team, OCKD-NET, Medicine (miscellaneous)
Abstract

Introduction: While chronic kidney disease (CKD) is one of the most important contributors to mortality from non-communicable diseases, the number of nephrologists is limited worldwide. Medical cooperation is a system of cooperation between primary care physicians and nephrological institutions, consisting of nephrologists and multidisciplinary care teams. Although it has been reported that multidisciplinary care teams contribute to the prevention of worsening renal functions and cardiovascular events, there are few studies on the effect of a medical cooperation system. Methods: We aimed to evaluate the effect of medical cooperation on all-cause mortality and renal prognosis in patients with CKD. One hundred and sixty-eight patients who visited the one hundred and sixty-three clinics and seven general hospitals of Okayama city were recruited between December 2009 and September 2016, and one hundred twenty-three patients were classified into a medical cooperation group. The outcome was defined as the incidence of all-cause mortality, or renal composite outcome (end-stage renal disease or 50% eGFR decline). We evaluated the effects on renal composite outcome and pre-ESRD mortality while incorporating the competing risk for the alternate outcome into a Fine–Gray subdistribution hazard model. Results: The medical cooperation group had more patients with glomerulonephritis (35.0% vs. 2.2%) and less nephrosclerosis (35.0% vs. 64.5%) than the primary care group. Throughout the follow-up period of 5.59 ± 2.78 years, 23 participants (13.7%) died, 41 participants (24.4%) reached 50% decline in eGFR, and 37 participants (22.0%) developed end-stage renal disease (ESRD). All-cause mortality was significantly reduced by medical cooperation (sHR 0.297, 95% CI 0.105–0.835, p = 0.021). However, there was a significant association between medical cooperation and CKD progression (sHR 3.069, 95% CI 1.225–7.687, p = 0.017). Conclusion: We evaluated mortality and ESRD using a CKD cohort with a long-term observation period and concluded that medical cooperation might be expected to influence the quality of medical care in the patients with CKD.

Published
2023
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16. Novel bovine viral diarrhea virus (BVDV) virus-like particle vaccine candidates presenting the E2 protein using the SpyTag/SpyCatcher system induce a robust neutralizing antibody response in mice

Author

Miki Katsura, Masaki Fukushima, Ken-ichiro Kameyama, Takehiko Kokuho, Yoichi Nakahira, and Kaoru Takeuchi

Subjects
Virology, General Medicine
Abstract

Bovine viral diarrhea virus (BVDV) is a pathogen of commercial consequence in cattle. Although many modified live and killed vaccines are commercially available, their drawbacks precipitate the need for new effective vaccines. Virus-like particles (VLPs) are a safe and powerful technology used in several human and veterinary vaccines; however, it is difficult to produce large amounts of BVDV VLPs. In this study, we generated red-spotted grouper nervous necrosis virus (RGNNV) VLPs presenting the BVDV E2 protein (domain I to IIIb) of the Nose (BVDV-1) or KZ-91-CP (BVDV-2) strain by exploiting SpyTag/SpyCatcher technology. Mice immunized twice with 30 μg of RGNNV VLPs conjugated with 10 μg of E2 proteins of the Nose or KZ-91-CP strain with a 14-day interval elicited high (1:512,000 to 1:1,024,000) and moderate (1:25,600 to 1:102,400) IgG titers against E2 proteins of homologous and heterologous strains, respectively. In addition, this prime-boost regimen induced strong (1:800 to 1:3,200) and weak (~1:10) neutralization titers against homologous and heterologous BVDV strains, respectively. Our results indicate that conjugation of the E2 protein to RGNNV VLPs strongly enhances the antigenicity of the E2 protein and that RGNNV VLPs presenting the E2 protein are promising BVDV vaccine candidates.

Published
2023
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17. Functionally conserved Pkd2, mutated in autosomal dominant polycystic kidney disease, localizes to the endoplasmic reticulum and regulates cytoplasmic calcium homeostasis in fission yeast

Author

Takayuki Koyano, Kazunori Kume, Kaori Onishi, Makoto Matsuyama, Masaki Fukushima, and Takashi Toda

Abstract

Mutations in PKD1 or PKD2 genes lead to autosomal dominant polycystic kidney disease (ADPKD) that is the most frequent family inherited renal disorder. These genes encode polycystin-1/PC-1 and polycycstin-2/PC-2, respectively. Although the genetic basis of ADPKD is well established, the crucial functions of polycystins underlying onset and development of cyst formation remain elusive. Fission yeast Schizosaccharomyces pombe has a single polycystin homolog, Pkd2, which is essential for cell growth. In this study, the truncation analyses of Pkd2 reveal that Pkd2 localizes to not only the plasma membrane but also the endoplasmic reticulum (ER) and regulates cytoplasmic calcium signaling in fission yeast. Internal transmembrane domains within Pkd2 are sufficient for these processes. Surprisingly, more than half of Pkd2 is not required for cell viability. Cytoplasmic calcium levels are mainly regulated through C-terminus of Pkd2. Importantly, human Pkd2 also localizes to the ER and furthermore, fully complements the loss of fission yeast Pkd2. As the functions of polycystin-2 are conserved, fission yeast provides a suitable model to study the mechanism of ADPKD as well as polycystins.

Published
2022
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24. Association of Deepening of the Upper Eyelid Sulcus with the Incidence of Blepharoptosis after Glaucoma Filtration Surgery

Author

Mitsuya Otsuka, Tatsuya Yunoki, Masaki Fukushima, and Atsushi Hayashi

Subjects
Male, medicine.medical_specialty, Glaucoma, Trabeculectomy, Postoperative Complications, Filtering surgery, Japan, Ophthalmology, medicine, Blepharoptosis, Humans, Intraocular Pressure, Aged, Retrospective Studies, business.industry, Incidence, Incidence (epidemiology), Eyelids, General Medicine, Sulcus, medicine.disease, humanities, medicine.anatomical_structure, Filtration surgery, Female, Observational study, Eyelid, business, Glaucoma, Open-Angle
Abstract

Purpose: To examine the clinical characteristics of patients who developed blepharoptosis after filtering surgery. Study Design: A retrospective, observational study. Methods: 96 eyes in 79 patient...

Published
2020
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26. Study on the cosmic ray intensity variation using scintillation counters for air shower observation

Author

Ryuji Takeishi, Daiki Shinto, Priti Shah, Michiyuki Chikawa, Ryo Nakamura, Shingo Kawana, Rasha Abbasi, Masahiro Takeda, Ken Honda, Takashi Sako, M. Ohnishi, Taichi Inadomi, Kinya Hibino, William Hanlon, Sergey Troitsky, Fumiya Shibata, Saori Kasami, G. Furlich, Takaaki Ishii, Aoi Iwasaki, Taka Tomida, Jyunsei Chiba, Dongsu Ryu, Fugo Yoshida, J. Remington, Ben Stokes, Min Hyo Kim, Koki Sato, Zach Zundel, Matt Potts, Kenta Yashiro, Hirokazu Iwakura, Kengo Sano, Federico R. Urban, Nobuyuki Sakurai, Y. Takagi, D. C. Rodriguez, HangBae Kim, Vladim Kuzmin, Hideki Tanaka, Shinnosuke Kurisu, Keitaro Fujita, Shigeharu Udo, Hisono Tokuno, Hideaki Shimodaira, Hyoming Jeong, Takeshi Okuda, Igor Tkachev, Naohiro Sone, Naoaki Hayashida, Tatsunobu Shibata, H. Oda, Ivan Kharuk, Ryuhei Arimura, S. Kawakami, Stanton Thomas, Akitoshi Oshima, Ryota Fujiwara, Toshiyuki Nonaka, Ryo Higuchi, Shunsuke Ozawa, Yuta Tanoue, Ricardo Gonzalez, Yoshiki Tsunesada, Daisuke Ikeda, Naoto Sakaki, Katsuaki Kasahara, Pierre Sokolsky, Yuya Oku, Arata Nakazawa, Katsumasa Kawata, Charlie Jui, Motoki Hayashi, Shigehiro Nagataki, Oleg Kalashev, Tiffany Wong, Samuel Blake, Hirotaka Ito, Shoichi Ogio, Yana Zhezher, Hiroyuki Sagawa, Kei Nakai, BayarJon Paul Lubsandorzhiev, Sang Woo Kim, Masaki Fukushima, Fumio Kakimoto, M. Yamamoto, Yuichiro Tameda, Heungsu Shin, Mayuko Minamino, K. Yamazaki, Kozo Fujisue, Jeremy Smith, Tareq Abu-Zayyad, John Matthews, Tsubasa Yoshioka, Koichi Tanaka, J. Yang, Tomoyuki Nakamura, Yukio Uchihori, Toru Nakamura, Koichi Sekino, Jon Paul Lundquist, Kenichi Kadota, Youngjoon Kwon, John Belz, Akimichi Taketa, Eiji Nishio, P. Tinyakov, Il Hung Park, Masato Takita, Ryota Fukushima, Ryota Onogi, J. H. Kim, Mikhail Kuznetsov, Maxim Pshirkov, Y. Takahashi, Mai Takamura, Yuto Arai, Isaac Myers, Hideyuki Kawai, Yuma Shibasaki, R. Mayta, Douglas Bergman, Grigory Rubtsov, Ryosuke Tsuda, Soomin Jeong, R. Sahara, T. Seki, Naoya Inoue, Yasunori Saito, Hiroyuki Matsumiya, Takafumi Uehama, Eiji Kido, Kazuhiro Machida, Telescope Array, Shoichi Kishigami, Masaomi Ono, Norimichi Shibata, Y. Omura, Monica Allen, Bokkyun Shin, ByongGu Cheon, Elliott Barcikowski, Dmitri Ivanov, Keijiro Mukai, Hideyuki Ohoka, Yusuke Kimura, Toshio Matsuyama, Manobu Tanaka, K. H. Lee, Jihee Kim, Gordon Thomson, Tom Stroman, Robert Cady, Toshihiro Fujii, Yuto Kubota, Y. Nakamura, and Kohei Yada

Subjects
Physics, Air shower, Scintillation counter, Cosmic ray, Astrophysics, Variation (astronomy), Intensity (heat transfer)
Published
2021
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27. Anisotropy search in the Ultra High Energy Cosmic Ray Spectrum in the Northern Hemisphere using latest data obtained with Telescope Array surface detector

Author

Grigory Rubtsov, John Matthews, Norimichi Shibata, Y. Omura, J. Yang, Fumiya Shibata, Shingo Kawana, M. Ohnishi, Taichi Inadomi, Matt Potts, William Hanlon, Monica Allen, Bokkyun Shin, Fugo Yoshida, Yuma Shibasaki, ByongGu Cheon, Ben Stokes, Douglas Bergman, Jyunsei Chiba, Dongsu Ryu, Toshihiro Fujii, Koki Sato, Yasunori Saito, M. Yamamoto, Hirokazu Iwakura, Y. Takagi, Ryuhei Arimura, Hideyuki Ohoka, Yuto Kubota, Federico R. Urban, Nobuyuki Sakurai, Kengo Sano, Mikhail Kuznetsov, Heungsu Shin, Ivan Kharuk, Yukio Uchihori, Keitaro Fujita, K. H. Lee, Jihee Kim, Yoshiki Tsunesada, Daisuke Ikeda, Hirotaka Ito, Sergey Troitsky, Yuto Arai, Ryota Onogi, J. H. Kim, Maxim Pshirkov, Takeshi Okuda, Y. Nakamura, Kohei Yada, Charlie Jui, BayarJon Paul Lubsandorzhiev, Mayuko Minamino, Hiroyuki Matsumiya, Igor Tkachev, R. Mayta, Hideki Tanaka, Naohiro Sone, Ryosuke Tsuda, Tiffany Wong, Taka Tomida, J. Remington, Masaki Fukushima, Takafumi Uehama, Aoi Iwasaki, Daiki Shinto, Hideaki Shimodaira, Hyoming Jeong, Shoichi Kishigami, Soomin Jeong, Shigeharu Udo, Eiji Kido, Hiroyuki Sagawa, Takashi Sako, Ryo Higuchi, Hisono Tokuno, H. Oda, Gordon Thomson, Tom Stroman, Priti Shah, Ryo Nakamura, Robert Cady, Kazuhiro Machida, Masahiro Takeda, Pierre Sokolsky, Naoaki Hayashida, Ken Honda, Tatsunobu Shibata, T. Seki, G. Furlich, Takaaki Ishii, R. Sahara, Fumio Kakimoto, Naoya Inoue, Akitoshi Oshima, Vladim Kuzmin, Ryuji Takeishi, Ryota Fukushima, Shigehiro Nagataki, Shunsuke Ozawa, K. Yamazaki, Masaomi Ono, Elliott Barcikowski, Toshiyuki Nonaka, Saori Kasami, Tareq Abu-Zayyad, Zach Zundel, Yana Zhezher, Kenta Yashiro, Dmitri Ivanov, D. C. Rodriguez, Ricardo Gonzalez, Samuel Blake, Sang Woo Kim, Kinya Hibino, Shoichi Ogio, Keijiro Mukai, HangBae Kim, Yusuke Kimura, Rasha Abbasi, Koichi Tanaka, Yuya Oku, Michiyuki Chikawa, Jon Paul Lundquist, Katsuaki Kasahara, Stanton Thomas, Katsumasa Kawata, Oleg Kalashev, Yuichiro Tameda, Tomoyuki Nakamura, Tsubasa Yoshioka, Arata Nakazawa, Masato Takita, Toru Nakamura, Telescope Array, Min Hyo Kim, Toshio Matsuyama, Kei Nakai, Ryota Fujiwara, Kenichi Kadota, Manobu Tanaka, Il Hung Park, Naoto Sakaki, S. Kawakami, Akimichi Taketa, Eiji Nishio, Hideyuki Kawai, Shinnosuke Kurisu, Jeremy Smith, Isaac Myers, Youngjoon Kwon, John Belz, Koichi Sekino, P. Tinyakov, Y. Takahashi, Mai Takamura, Yuta Tanoue, Motoki Hayashi, and Kozo Fujisue

Subjects
Surface (mathematics), Telescope, Physics, law, Detector, Northern Hemisphere, Astrophysics, Ultra-high-energy cosmic ray, Anisotropy, law.invention
Published
2021
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28. The measurements of the cosmic ray energy spectrum and the depth of maximum shower development of Telescope Array Hybrid trigger events

Author

Katsuaki Kasahara, Shinnosuke Kurisu, Katsumasa Kawata, Shingo Kawana, William Hanlon, Tsubasa Yoshioka, R. Sahara, Hideaki Shimodaira, Hyoming Jeong, Ryo Higuchi, Norimichi Shibata, Monica Allen, Bokkyun Shin, Jeremy Smith, Y. Omura, Vladim Kuzmin, G. Furlich, Takaaki Ishii, Akimichi Taketa, Toshio Matsuyama, Eiji Nishio, ByongGu Cheon, K. Yamazaki, Tareq Abu-Zayyad, Toshiyuki Nonaka, Hideyuki Ohoka, D. C. Rodriguez, Fumiya Shibata, Hiroyuki Matsumiya, Fugo Yoshida, HangBae Kim, Hiroyuki Sagawa, Ricardo Gonzalez, Pierre Sokolsky, Tatsunobu Shibata, Hideyuki Kawai, Takafumi Uehama, Manobu Tanaka, Rasha Abbasi, Takeshi Okuda, Youngjoon Kwon, John Belz, Yuma Shibasaki, Shigehiro Nagataki, Matt Potts, Yana Zhezher, Mikhail Kuznetsov, Akitoshi Oshima, Igor Tkachev, Sang Woo Kim, Eiji Kido, Koichi Tanaka, K. H. Lee, Jihee Kim, Kazuhiro Machida, Isaac Myers, Naohiro Sone, Shunsuke Ozawa, Hideki Tanaka, Heungsu Shin, Douglas Bergman, Gordon Thomson, Ryo Nakamura, Jon Paul Lundquist, Tom Stroman, Robert Cady, Yuta Tanoue, Ben Stokes, H. Oda, Grigory Rubtsov, Tomoyuki Nakamura, Yasunori Saito, Yuto Arai, Motoki Hayashi, Ryota Fujiwara, Federico R. Urban, Nobuyuki Sakurai, Ryosuke Tsuda, Hirotaka Ito, Hisono Tokuno, Elliott Barcikowski, Charlie Jui, Soomin Jeong, Naoto Sakaki, Kozo Fujisue, BayarJon Paul Lubsandorzhiev, Mayuko Minamino, Yuya Oku, Oleg Kalashev, Dmitri Ivanov, Fumio Kakimoto, Arata Nakazawa, Kenta Yashiro, Kei Nakai, T. Seki, Naoya Inoue, Keijiro Mukai, Min Hyo Kim, Yusuke Kimura, S. Kawakami, Stanton Thomas, M. Ohnishi, Taichi Inadomi, Koki Sato, Sergey Troitsky, Kengo Sano, Aoi Iwasaki, Toshihiro Fujii, Michiyuki Chikawa, Toru Nakamura, Taka Tomida, J. Remington, Kenichi Kadota, Yuto Kubota, Il Hung Park, Saori Kasami, Y. Nakamura, Kohei Yada, Koichi Sekino, Naoaki Hayashida, P. Tinyakov, Ryuji Takeishi, Ryuhei Arimura, Yoshiki Tsunesada, Daisuke Ikeda, Tiffany Wong, Masaki Fukushima, Takashi Sako, Zach Zundel, John Matthews, J. Yang, Daiki Shinto, Priti Shah, Jyunsei Chiba, Dongsu Ryu, Masahiro Takeda, Ken Honda, Hirokazu Iwakura, Y. Takagi, Shigeharu Udo, Keitaro Fujita, Ryota Fukushima, Ivan Kharuk, M. Yamamoto, Yukio Uchihori, Ryota Onogi, J. H. Kim, R. Mayta, Kinya Hibino, Yuichiro Tameda, Masato Takita, Shoichi Kishigami, Y. Takahashi, Mai Takamura, Masaomi Ono, Telescope Array, Samuel Blake, Shoichi Ogio, and Maxim Pshirkov

Subjects
Telescope, Physics, Shower, law, Energy spectrum, Astronomy, Cosmic ray, law.invention
Published
2021
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29. Cosmic ray energy spectrum in the 2nd knee region measured by the TALE-SD array

Author

Taka Tomida, J. Remington, G. Furlich, Takaaki Ishii, D. C. Rodriguez, Stanton Thomas, Hideki Tanaka, HangBae Kim, Fumiya Shibata, Naoaki Hayashida, Hiroyuki Matsumiya, ByongGu Cheon, Fugo Yoshida, Michiyuki Chikawa, Pierre Sokolsky, Shigehiro Nagataki, Yana Zhezher, Isaac Myers, Maxim Pshirkov, Sang Woo Kim, Matt Potts, Telescope Array, Hisono Tokuno, Ryuhei Arimura, Vladim Kuzmin, Daiki Shinto, Toru Nakamura, Takafumi Uehama, Koichi Sekino, Tomoyuki Nakamura, Takeshi Okuda, P. Tinyakov, Heungsu Shin, R. Sahara, Aoi Iwasaki, Yoshiki Tsunesada, Kenichi Kadota, Priti Shah, Daisuke Ikeda, Igor Tkachev, Il Hung Park, Toshiyuki Nonaka, Hideyuki Ohoka, Shoichi Kishigami, Rasha Abbasi, Masahiro Takeda, Naohiro Sone, Arata Nakazawa, Y. Takahashi, Mai Takamura, Ricardo Gonzalez, Tiffany Wong, Eiji Kido, Kei Nakai, Ben Stokes, Kazuhiro Machida, Masaki Fukushima, Ken Honda, H. Oda, Katsuaki Kasahara, Masaomi Ono, Yuto Arai, Toshihiro Fujii, Jyunsei Chiba, Katsumasa Kawata, Takashi Sako, Charlie Jui, Yuta Tanoue, Dongsu Ryu, Federico R. Urban, Nobuyuki Sakurai, Motoki Hayashi, BayarJon Paul Lubsandorzhiev, Mayuko Minamino, Kenta Yashiro, Yuto Kubota, Saori Kasami, Kozo Fujisue, Tsubasa Yoshioka, John Matthews, Hirokazu Iwakura, Shingo Kawana, Y. Takagi, Ryosuke Tsuda, Soomin Jeong, Yasunori Saito, Zach Zundel, J. Yang, William Hanlon, Fumio Kakimoto, Grigory Rubtsov, Ryuji Takeishi, Tatsunobu Shibata, Samuel Blake, Shoichi Ogio, T. Seki, Akitoshi Oshima, Yuya Oku, M. Ohnishi, Ryota Fujiwara, Taichi Inadomi, Y. Nakamura, Oleg Kalashev, Kohei Yada, Keitaro Fujita, Shunsuke Ozawa, Koki Sato, Yuichiro Tameda, Monica Allen, Bokkyun Shin, Naoto Sakaki, Naoya Inoue, Kengo Sano, Ryota Fukushima, Hirotaka Ito, Youngjoon Kwon, Ivan Kharuk, Masato Takita, John Belz, Norimichi Shibata, Y. Omura, Elliott Barcikowski, Dmitri Ivanov, Keijiro Mukai, Yusuke Kimura, Hideaki Shimodaira, Hyoming Jeong, Kinya Hibino, Ryo Higuchi, Toshio Matsuyama, K. Yamazaki, Tareq Abu-Zayyad, Manobu Tanaka, K. H. Lee, Jihee Kim, Gordon Thomson, Tom Stroman, Akimichi Taketa, Robert Cady, Mikhail Kuznetsov, Eiji Nishio, M. Yamamoto, Yukio Uchihori, Ryota Onogi, J. H. Kim, R. Mayta, Shigeharu Udo, Hideyuki Kawai, Shinnosuke Kurisu, Ryo Nakamura, Jeremy Smith, Yuma Shibasaki, Min Hyo Kim, Douglas Bergman, S. Kawakami, Hiroyuki Sagawa, Koichi Tanaka, Jon Paul Lundquist, and Sergey Troitsky

Subjects
Physics, Energy spectrum, Cosmic ray, Knee region, Astrophysics
Published
2021
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30. Cosmic Ray Composition between 2 PeV and 2 EeV measured by the TALE Fluorescence Detector

Author

Shigeharu Udo, Daiki Shinto, Fumiya Shibata, Priti Shah, Stanton Thomas, Norimichi Shibata, Y. Omura, Matt Potts, Masahiro Takeda, Ken Honda, Ryo Nakamura, Youngjoon Kwon, Vladim Kuzmin, John Belz, Telescope Array, Yasunori Saito, Shinnosuke Kurisu, Yuta Tanoue, Motoki Hayashi, Tatsunobu Shibata, ByongGu Cheon, Saori Kasami, M. Yamamoto, Takeshi Okuda, Igor Tkachev, Naohiro Sone, Fumio Kakimoto, John N. Matthews, K. H. Lee, Jihee Kim, Tomoyuki Nakamura, Yukio Uchihori, J. P. Lundquist, Akitoshi Oshima, Hideyuki Ohoka, Michiyuki Chikawa, Toru Nakamura, Fugo Yoshida, Ryota Onogi, J. H. Kim, Keitaro Fujita, Kozo Fujisue, Hideki Tanaka, Shunsuke Ozawa, Jeremy Smith, Kenichi Kadota, Il Hung Park, H. Oda, Takashi Sako, Charlie Jui, Hiroyuki Matsumiya, R. Mayta, Shoichi Kishigami, Akimichi Taketa, Gordon Thomson, Hisono Tokuno, BayarJon Paul Lubsandorzhiev, Mayuko Minamino, Takafumi Uehama, Ryota Fujiwara, Eiji Nishio, Sergey Troitsky, Kinya Hibino, Min Hyo Kim, Masaomi Ono, Maxim Pshirkov, Tom Stroman, Robert Cady, Pierre Sokolsky, Taka Tomida, Shingo Kawana, Eiji Kido, Kazuhiro Machida, J. Remington, Naoto Sakaki, Katsuaki Kasahara, Shigehiro Nagataki, Yana Zhezher, M. Ohnishi, Taichi Inadomi, Yuto Kubota, Zach Zundel, Ben Stokes, William Hanlon, Sang Woo Kim, Koki Sato, Federico R. Urban, Nobuyuki Sakurai, Hideyuki Kawai, Yuma Shibasaki, Ryuhei Arimura, Katsumasa Kawata, J. Yang, Koichi Sekino, Monica Allen, Bokkyun Shin, Naoaki Hayashida, Kengo Sano, P. Tinyakov, Yoshiki Tsunesada, Daisuke Ikeda, Y. Nakamura, Douglas Bergman, Kohei Yada, S. Kawakami, Kenta Yashiro, Y. Takahashi, Mai Takamura, Tiffany Wong, Heungsu Shin, Tsubasa Yoshioka, Masaki Fukushima, Yuya Oku, Oleg Kalashev, Hiroyuki Sagawa, Samuel Blake, Shoichi Ogio, Toshiyuki Nonaka, Ricardo Gonzalez, Yuichiro Tameda, Yuto Arai, Koichi Tanaka, Rasha Abbasi, T. Fujii, Masato Takita, Toshio Matsuyama, Elliott Barcikowski, Dmitri Ivanov, Keijiro Mukai, Manobu Tanaka, Yusuke Kimura, Ryosuke Tsuda, Soomin Jeong, T. Seki, Naoya Inoue, Arata Nakazawa, Kei Nakai, G. Furlich, Takaaki Ishii, D. C. Rodriguez, HangBae Kim, Isaac Myers, Hideaki Shimodaira, Hyoming Jeong, Ryo Higuchi, K. Yamazaki, Tareq Abu-Zayyad, Mikhail Kuznetsov, Grigory Rubtsov, Hirotaka Ito, Aoi Iwasaki, Ivan Kharuk, Ryuji Takeishi, R. Sahara, Ryota Fukushima, Jyunsei Chiba, Dongsu Ryu, Hirokazu Iwakura, and Y. Takagi

Subjects
Physics, Cosmic ray, Astrophysics, Fluorescence spectroscopy
Published
2021
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31. The status of the TALE surface detector array and TALE infill project

Author

Takashi Sako, Zach Zundel, Shigeharu Udo, Kenta Yashiro, Toru Nakamura, Kenichi Kadota, Il Hung Park, Min Hyo Kim, Ryo Nakamura, Tatsunobu Shibata, R. Sahara, Noemie Globus, Elliott Barcikowski, S. Kawakami, Akitoshi Oshima, Dmitri Ivanov, Grigory Rubtsov, Fugo Yoshida, Shunsuke Ozawa, Keijiro Mukai, Charlie Jui, BayarJon Paul Lubsandorzhiev, Yusuke Kimura, Fumio Kakimoto, Mayuko Minamino, Saori Kasami, G. Furlich, Takaaki Ishii, Norimichi Shibata, Fumiya Shibata, Hiroyuki Sagawa, Y. Omura, D. C. Rodriguez, Matt Potts, Aoi Iwasaki, HangBae Kim, Koichi Tanaka, Jon Paul Lundquist, Ryota Fukushima, Monica Allen, Bokkyun Shin, Yuya Oku, Ryuji Takeishi, Vladim Kuzmin, Oleg Kalashev, Telescope Array, M. Yamamoto, Youngjoon Kwon, Arata Nakazawa, John Belz, Kei Nakai, Yukio Uchihori, Stanton Thomas, Yasunori Saito, Maxim Pshirkov, Michiyuki Chikawa, Ben Stokes, Ryota Onogi, J. H. Kim, Hirotaka Ito, R. Mayta, Ryuhei Arimura, Shoichi Kishigami, Pierre Sokolsky, Federico R. Urban, Nobuyuki Sakurai, Hideki Tanaka, Kinya Hibino, Yoshiki Tsunesada, Shigehiro Nagataki, Yana Zhezher, Masaomi Ono, Sang Woo Kim, Sergey Troitsky, Hisono Tokuno, Taka Tomida, J. Remington, Rasha Abbasi, M. Ohnishi, Taichi Inadomi, Naoaki Hayashida, Hideaki Shimodaira, Hyoming Jeong, Isaac Myers, Koki Sato, Ryo Higuchi, Toshihiro Fujii, Tomoyuki Nakamura, Hiroyuki Matsumiya, Ryota Fujiwara, Takafumi Uehama, ByongGu Cheon, Yuto Kubota, Eiji Kido, Naoto Sakaki, Kazuhiro Machida, Kengo Sano, Katsuaki Kasahara, K. Yamazaki, Katsumasa Kawata, Tareq Abu-Zayyad, Tsubasa Yoshioka, Takeshi Okuda, Igor Tkachev, Y. Nakamura, Kohei Yada, Naohiro Sone, Mikhail Kuznetsov, Hideyuki Ohoka, H. Oda, Akimichi Taketa, Eiji Nishio, Ivan Kharuk, Hideyuki Kawai, Yuma Shibasaki, Jyunsei Chiba, Dongsu Ryu, Hirokazu Iwakura, Y. Takagi, Douglas Bergman, Shinnosuke Kurisu, Jeremy Smith, Toshio Matsuyama, K. H. Lee, Jihee Kim, Gordon Thomson, Tom Stroman, Robert Cady, Manobu Tanaka, Keitaro Fujita, Daiki Shinto, Priti Shah, Masahiro Takeda, Ken Honda, John Matthews, J. Yang, Koichi Sekino, P. Tinyakov, Y. Takahashi, Mai Takamura, Daisuke Ikeda, Tiffany Wong, Masaki Fukushima, Yuta Tanoue, Motoki Hayashi, Heungsu Shin, Kozo Fujisue, Yuto Arai, Ryosuke Tsuda, Soomin Jeong, Shingo Kawana, William Hanlon, T. Seki, Toshiyuki Nonaka, Ricardo Gonzalez, Naoya Inoue, Yuichiro Tameda, Masato Takita, Samuel Blake, and Shoichi Ogio

Subjects
Surface (mathematics), Optics, business.industry, Infill, Detector array, business, Geology
Published
2021
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32. Current status and prospects of surface detector of the TAx4 experiment

Author

Katsumasa Kawata, Grigory Rubtsov, Tsubasa Yoshioka, Tatsunobu Shibata, Yuichiro Tameda, Kenta Yashiro, Akitoshi Oshima, Fugo Yoshida, Jyunsei Chiba, Ryosuke Tsuda, Soomin Jeong, M. Yamamoto, Ryo Nakamura, Shunsuke Ozawa, Dongsu Ryu, Takashi Sako, Shingo Kawana, Hirokazu Iwakura, Y. Takagi, ByongGu Cheon, T. Seki, Naoya Inoue, Yukio Uchihori, Hideaki Shimodaira, Hyoming Jeong, Hideki Tanaka, Aoi Iwasaki, John Matthews, Ryota Onogi, J. H. Kim, William Hanlon, Ryo Higuchi, Fumiya Shibata, J. Yang, Hisono Tokuno, Masato Takita, Akimichi Taketa, M. Ohnishi, Taichi Inadomi, Hideyuki Ohoka, Ryota Fujiwara, Youngjoon Kwon, John Belz, R. Mayta, Yuta Tanoue, Koki Sato, Eiji Nishio, Motoki Hayashi, Naoto Sakaki, Ryota Fukushima, Matt Potts, Ivan Kharuk, K. Yamazaki, Ben Stokes, Sergey Troitsky, Min Hyo Kim, Tareq Abu-Zayyad, Kengo Sano, Kozo Fujisue, Zach Zundel, Kinya Hibino, Saori Kasami, Toru Nakamura, R. Sahara, Taka Tomida, J. Remington, Federico R. Urban, Nobuyuki Sakurai, Takeshi Okuda, Igor Tkachev, Naohiro Sone, Samuel Blake, Shoichi Ogio, Kenichi Kadota, Il Hung Park, Hideyuki Kawai, Rasha Abbasi, Keitaro Fujita, Koichi Sekino, H. Oda, Mikhail Kuznetsov, Heungsu Shin, Shinnosuke Kurisu, Toshiyuki Nonaka, Ricardo Gonzalez, P. Tinyakov, S. Kawakami, Charlie Jui, Fumio Kakimoto, Yuto Arai, Naoaki Hayashida, Shigeharu Udo, Yuya Oku, Michiyuki Chikawa, Oleg Kalashev, BayarJon Paul Lubsandorzhiev, Mayuko Minamino, Y. Takahashi, Mai Takamura, Jeremy Smith, Ryuhei Arimura, Daiki Shinto, Monica Allen, Bokkyun Shin, Yuma Shibasaki, Priti Shah, Hiroyuki Sagawa, Masahiro Takeda, Vladim Kuzmin, Yoshiki Tsunesada, Daisuke Ikeda, Ken Honda, Toshio Matsuyama, Douglas Bergman, Tiffany Wong, Koichi Tanaka, Masaki Fukushima, Jon Paul Lundquist, Elliott Barcikowski, Dmitri Ivanov, Keijiro Mukai, Yusuke Kimura, Manobu Tanaka, K. H. Lee, Jihee Kim, Maxim Pshirkov, Gordon Thomson, Toshihiro Fujii, Tom Stroman, Robert Cady, Yuto Kubota, Y. Nakamura, Kohei Yada, Pierre Sokolsky, Shigehiro Nagataki, Shoichi Kishigami, Yana Zhezher, Sang Woo Kim, Masaomi Ono, Telescope Array, Tomoyuki Nakamura, Stanton Thomas, Hiroyuki Matsumiya, Takafumi Uehama, Eiji Kido, Kazuhiro Machida, Yasunori Saito, Isaac Myers, Norimichi Shibata, Y. Omura, G. Furlich, Takaaki Ishii, D. C. Rodriguez, HangBae Kim, Arata Nakazawa, Kei Nakai, Hirotaka Ito, Ryuji Takeishi, and Katsuaki Kasahara

Subjects
Physics, Surface (mathematics), Optics, business.industry, Detector, Current (fluid), business
Published
2021
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33. Cosmic Ray Composition in the Second Knee Region as Measured by the TALE Hybrid Detector

Author

ByongGu Cheon, Hiroyuki Matsumiya, Charlie Jui, BayarJon Paul Lubsandorzhiev, Mayuko Minamino, Takashi Sako, Ivan Kharuk, Takeshi Okuda, Igor Tkachev, Takafumi Uehama, Hideyuki Ohoka, Daiki Shinto, Priti Shah, Isaac Myers, K. H. Lee, Jihee Kim, Telescope Array, Naohiro Sone, Eiji Kido, Fugo Yoshida, Kazuhiro Machida, Aoi Iwasaki, Hideaki Shimodaira, Hyoming Jeong, Masahiro Takeda, Ken Honda, H. Oda, Zach Zundel, Yuta Tanoue, Fumiya Shibata, Gordon Thomson, Tom Stroman, Robert Cady, Shoichi Kishigami, Ryo Higuchi, Youngjoon Kwon, Sergey Troitsky, Motoki Hayashi, Masaomi Ono, John Belz, Kozo Fujisue, Stanton Thomas, Kinya Hibino, Elliott Barcikowski, Matt Potts, Taka Tomida, Dmitri Ivanov, John Matthews, Samuel Blake, Ryuhei Arimura, J. Remington, M. Ohnishi, Taichi Inadomi, Koichi Sekino, Shoichi Ogio, Keijiro Mukai, J. Yang, P. Tinyakov, K. Yamazaki, G. Furlich, Takaaki Ishii, Pierre Sokolsky, Norimichi Shibata, Yuichiro Tameda, Shingo Kawana, Yusuke Kimura, Y. Omura, Tareq Abu-Zayyad, Yoshiki Tsunesada, Ryuji Takeishi, Daisuke Ikeda, Y. Takahashi, Mai Takamura, Koki Sato, Shigehiro Nagataki, Yana Zhezher, Jyunsei Chiba, Dongsu Ryu, William Hanlon, Hiroyuki Sagawa, Shigeharu Udo, Sang Woo Kim, D. C. Rodriguez, Kengo Sano, Tatsunobu Shibata, Tiffany Wong, Hirokazu Iwakura, Y. Takagi, HangBae Kim, Toshihiro Fujii, Mikhail Kuznetsov, Masato Takita, Keitaro Fujita, Yasunori Saito, Masaki Fukushima, Akitoshi Oshima, Yuto Kubota, Vladim Kuzmin, Kenta Yashiro, Grigory Rubtsov, Shunsuke Ozawa, Tomoyuki Nakamura, Manobu Tanaka, Y. Nakamura, Kohei Yada, Koichi Tanaka, Ryosuke Tsuda, Fumio Kakimoto, Ben Stokes, Ryota Fukushima, Naoaki Hayashida, M. Yamamoto, Monica Allen, Bokkyun Shin, Soomin Jeong, Michiyuki Chikawa, R. Sahara, Jon Paul Lundquist, Federico R. Urban, Arata Nakazawa, Nobuyuki Sakurai, Toshiyuki Nonaka, Yukio Uchihori, Kei Nakai, Ryota Onogi, J. H. Kim, Ricardo Gonzalez, Maxim Pshirkov, Toshio Matsuyama, T. Seki, Naoya Inoue, R. Mayta, Hirotaka Ito, Min Hyo Kim, S. Kawakami, Heungsu Shin, Yuto Arai, Saori Kasami, Ryo Nakamura, Hideki Tanaka, Hisono Tokuno, Yuma Shibasaki, Douglas Bergman, Akimichi Taketa, Eiji Nishio, Yuya Oku, Hideyuki Kawai, Shinnosuke Kurisu, Oleg Kalashev, Jeremy Smith, Toru Nakamura, Kenichi Kadota, Il Hung Park, Ryota Fujiwara, Naoto Sakaki, Katsuaki Kasahara, Katsumasa Kawata, Tsubasa Yoshioka, and Rasha Abbasi

Subjects
Physics, Detector, Cosmic ray, Knee region, Astrophysics, Composition (combinatorics)
Published
2021
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34. Effects of Galactic magnetic field on the UHECR anisotropy studies

Author

Tomoyuki Nakamura, Sergey Troitsky, Taka Tomida, M. Yamamoto, Fugo Yoshida, J. Remington, M. Ohnishi, Taichi Inadomi, Elliott Barcikowski, Stanton Thomas, Pierre Sokolsky, Yuichiro Tameda, Hideaki Shimodaira, Hyoming Jeong, Dmitri Ivanov, R. Sahara, Shigehiro Nagataki, Yana Zhezher, Ryota Fujiwara, Sang Woo Kim, Yukio Uchihori, Manobu Tanaka, Ryo Higuchi, Ivan Kharuk, Keijiro Mukai, Koki Sato, ByongGu Cheon, Norimichi Shibata, Yuma Shibasaki, Ryota Onogi, J. H. Kim, Y. Omura, Keitaro Fujita, Naoto Sakaki, Aoi Iwasaki, Yusuke Kimura, K. H. Lee, Jihee Kim, Hideyuki Ohoka, R. Mayta, Kengo Sano, Gordon Thomson, K. Yamazaki, Tom Stroman, Robert Cady, Tareq Abu-Zayyad, Kinya Hibino, Toru Nakamura, Yasunori Saito, Douglas Bergman, Naoaki Hayashida, Takeshi Okuda, Igor Tkachev, Mikhail Kuznetsov, Min Hyo Kim, Kenichi Kadota, Michiyuki Chikawa, Rasha Abbasi, Ryosuke Tsuda, Yuta Tanoue, Naohiro Sone, Il Hung Park, Masato Takita, Soomin Jeong, John N. Matthews, Katsuaki Kasahara, H. Oda, Saori Kasami, Shinnosuke Kurisu, Motoki Hayashi, Takashi Sako, Katsumasa Kawata, Youngjoon Kwon, John Belz, Ben Stokes, J. P. Lundquist, Arata Nakazawa, S. Kawakami, Monica Allen, Bokkyun Shin, T. Seki, Yuto Kubota, Kozo Fujisue, Federico R. Urban, Hiroyuki Matsumiya, Nobuyuki Sakurai, Tsubasa Yoshioka, Naoya Inoue, Vladim Kuzmin, J. Yang, Shigeharu Udo, Kei Nakai, Kenta Yashiro, T. Fujii, Hiroyuki Sagawa, Maxim Pshirkov, Takafumi Uehama, Shingo Kawana, Kazumasa Kawata, Toshio Matsuyama, Y. Nakamura, Jeremy Smith, Yuya Oku, Kohei Yada, Koichi Tanaka, Akimichi Taketa, Koichi Sekino, Hideki Tanaka, Oleg Kalashev, Eiji Kido, Tatsunobu Shibata, William Hanlon, Daiki Shinto, Eiji Nishio, Kazuhiro Machida, Jyunsei Chiba, Dongsu Ryu, Telescope Array, Zach Zundel, Akitoshi Oshima, Priti Shah, P. Tinyakov, Heungsu Shin, Fumio Kakimoto, Shunsuke Ozawa, Isaac Myers, Ryuhei Arimura, Hisono Tokuno, Masahiro Takeda, Ken Honda, Ryuji Takeishi, Yoshiki Tsunesada, Daisuke Ikeda, Hideyuki Kawai, Hirokazu Iwakura, Y. Takagi, Tiffany Wong, Samuel Blake, Masaki Fukushima, Shoichi Ogio, Yuto Arai, Toshiyuki Nonaka, Shoichi Kishigami, Ricardo Gonzalez, G. Furlich, Takaaki Ishii, Y. Takahashi, Mai Takamura, Masaomi Ono, D. C. Rodriguez, HangBae Kim, Grigory Rubtsov, Ryota Fukushima, Hirotaka Ito, Ryo Nakamura, Charlie Jui, BayarJon Paul Lubsandorzhiev, Mayuko Minamino, Fumiya Shibata, and Matt Potts

Subjects
Physics, Astrophysics, Anisotropy, Magnetic field
Published
2021
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35. Mass composition of Telescope Array's surface detectors events using deep learning

Author

Hideaki Shimodaira, Hyoming Jeong, Hiroyuki Sagawa, Fumiya Shibata, Ryuji Takeishi, Ryo Higuchi, Youngjoon Kwon, John Belz, Hideyuki Ohoka, Ryo Nakamura, Rasha Abbasi, Daiki Shinto, Ryuhei Arimura, Koichi Tanaka, Yoshiki Tsunesada, Daisuke Ikeda, Michiyuki Chikawa, Tiffany Wong, Masaki Fukushima, Matt Potts, Yuma Shibasaki, Priti Shah, Jon Paul Lundquist, K. Yamazaki, Pierre Sokolsky, Katsuaki Kasahara, Katsumasa Kawata, Tareq Abu-Zayyad, Fugo Yoshida, Masahiro Takeda, Takashi Sako, Ken Honda, Zach Zundel, Shigehiro Nagataki, Yana Zhezher, Ben Stokes, Tsubasa Yoshioka, Kenta Yashiro, Sergey Troitsky, R. Sahara, Douglas Bergman, Sang Woo Kim, Taka Tomida, Shingo Kawana, Charlie Jui, BayarJon Paul Lubsandorzhiev, J. Remington, Mayuko Minamino, Mikhail Kuznetsov, Min Hyo Kim, Shinnosuke Kurisu, William Hanlon, Ryota Fujiwara, Elliott Barcikowski, Dmitri Ivanov, Monica Allen, Naoto Sakaki, Tomoyuki Nakamura, G. Furlich, Takaaki Ishii, Federico R. Urban, Nobuyuki Sakurai, Saori Kasami, Keijiro Mukai, Bokkyun Shin, Toshio Matsuyama, K. H. Lee, Jihee Kim, Gordon Thomson, Ryota Fukushima, Samuel Blake, Shoichi Ogio, Hirotaka Ito, Yusuke Kimura, Tom Stroman, Robert Cady, Naoaki Hayashida, Norimichi Shibata, Y. Omura, S. Kawakami, D. C. Rodriguez, Keitaro Fujita, Jeremy Smith, HangBae Kim, Takeshi Okuda, Igor Tkachev, Akimichi Taketa, Hideki Tanaka, Stanton Thomas, Naohiro Sone, Isaac Myers, Eiji Nishio, Yuya Oku, Aoi Iwasaki, Oleg Kalashev, Hiroyuki Matsumiya, Toshihiro Fujii, Hisono Tokuno, H. Oda, Jyunsei Chiba, Grigory Rubtsov, Dongsu Ryu, Manobu Tanaka, Yuto Kubota, Koichi Sekino, Takafumi Uehama, Maxim Pshirkov, Hideyuki Kawai, P. Tinyakov, Toru Nakamura, Kenichi Kadota, M. Ohnishi, Y. Nakamura, Il Hung Park, Kohei Yada, Hirokazu Iwakura, Taichi Inadomi, Y. Takagi, Y. Takahashi, Mai Takamura, Eiji Kido, Kazuhiro Machida, Arata Nakazawa, Koki Sato, John Matthews, Toshiyuki Nonaka, Kei Nakai, Ivan Kharuk, J. Yang, Ricardo Gonzalez, Kengo Sano, Yasunori Saito, Yuta Tanoue, Fumio Kakimoto, Motoki Hayashi, Yuichiro Tameda, Kozo Fujisue, Shoichi Kishigami, Masaomi Ono, Masato Takita, Telescope Array, Shigeharu Udo, Kinya Hibino, M. Yamamoto, Yukio Uchihori, Ryota Onogi, J. H. Kim, R. Mayta, Vladim Kuzmin, Ryosuke Tsuda, Soomin Jeong, T. Seki, Naoya Inoue, Heungsu Shin, Yuto Arai, Tatsunobu Shibata, Akitoshi Oshima, Shunsuke Ozawa, and ByongGu Cheon

Subjects
Surface (mathematics), Telescope, Physics, Optics, business.industry, law, Deep learning, Detector, Artificial intelligence, Mass composition, business, law.invention
Published
2021
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36. FOV direction and image size calibration of Fluorescence Detector using light source on UAV

Author

Telescope Array, Yasunori Saito, Shoichi Kishigami, Hideaki Shimodaira, Hyoming Jeong, Masaomi Ono, Ryo Higuchi, Ryuhei Arimura, Fugo Yoshida, Ryo Nakamura, Tomoyuki Nakamura, Charlie Jui, Min Hyo Kim, M. Ohnishi, Taichi Inadomi, Hideki Tanaka, Hisono Tokuno, BayarJon Paul Lubsandorzhiev, John Matthews, Yoshiki Tsunesada, Heungsu Shin, Manobu Tanaka, Koki Sato, Mayuko Minamino, J. Yang, Daisuke Ikeda, K. Yamazaki, Tareq Abu-Zayyad, M. Yamamoto, S. Kawakami, Kengo Sano, Sergey Troitsky, Fumio Kakimoto, Yuto Arai, Tiffany Wong, Taka Tomida, J. Remington, Koichi Sekino, Stanton Thomas, Kenta Yashiro, Ryosuke Tsuda, Saori Kasami, Monica Allen, Yukio Uchihori, Masaki Fukushima, Fumiya Shibata, Ben Stokes, Toshio Matsuyama, P. Tinyakov, Mikhail Kuznetsov, Soomin Jeong, Bokkyun Shin, Pierre Sokolsky, Norimichi Shibata, Hiroyuki Sagawa, K. H. Lee, Jihee Kim, Y. Omura, Ryota Onogi, J. H. Kim, Gordon Thomson, G. Furlich, Takaaki Ishii, Tom Stroman, Robert Cady, Y. Takahashi, Mai Takamura, ByongGu Cheon, Matt Potts, Shigehiro Nagataki, Yana Zhezher, Keitaro Fujita, Federico R. Urban, Nobuyuki Sakurai, Koichi Tanaka, Naoaki Hayashida, T. Seki, Naoya Inoue, R. Mayta, Jon Paul Lundquist, Sang Woo Kim, Hiroyuki Matsumiya, Yuta Tanoue, Yuichiro Tameda, Kinya Hibino, Motoki Hayashi, Takafumi Uehama, D. C. Rodriguez, Eiji Kido, Maxim Pshirkov, Kozo Fujisue, Takeshi Okuda, Kazuhiro Machida, HangBae Kim, Hideyuki Ohoka, Igor Tkachev, Naohiro Sone, Shigeharu Udo, Shinnosuke Kurisu, Grigory Rubtsov, Tatsunobu Shibata, H. Oda, Michiyuki Chikawa, Daiki Shinto, Arata Nakazawa, Kei Nakai, Akitoshi Oshima, Priti Shah, R. Sahara, Jeremy Smith, Akimichi Taketa, Eiji Nishio, Masahiro Takeda, Takashi Sako, Vladim Kuzmin, Ken Honda, Masato Takita, Shunsuke Ozawa, Isaac Myers, Hideyuki Kawai, Yuma Shibasaki, Douglas Bergman, Samuel Blake, Shoichi Ogio, Zach Zundel, Jyunsei Chiba, Dongsu Ryu, Hirokazu Iwakura, Y. Takagi, Ivan Kharuk, Toru Nakamura, Elliott Barcikowski, Kenichi Kadota, Dmitri Ivanov, Il Hung Park, Keijiro Mukai, Yusuke Kimura, Yuya Oku, Oleg Kalashev, Ryota Fukushima, Youngjoon Kwon, John Belz, Toshihiro Fujii, Yuto Kubota, Y. Nakamura, Kohei Yada, Hirotaka Ito, Rasha Abbasi, Aoi Iwasaki, Ryota Fujiwara, Naoto Sakaki, Katsuaki Kasahara, Katsumasa Kawata, Tsubasa Yoshioka, Ryuji Takeishi, Shingo Kawana, William Hanlon, Toshiyuki Nonaka, and Ricardo Gonzalez

Subjects
Physics, Light source, Optics, business.industry, Calibration, business, Image resolution, Fluorescence spectroscopy
Published
2021
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37. UHECR mass composition from anisotropy of their arrival directions with the Telescope Array SD

Author

Katsuaki Kasahara, Ryota Fukushima, Takeshi Okuda, Igor Tkachev, Katsumasa Kawata, Daiki Shinto, Naohiro Sone, ByongGu Cheon, Shoichi Kishigami, Norimichi Shibata, Manobu Tanaka, Grigory Rubtsov, Ryuhei Arimura, M. Yamamoto, H. Oda, Masaomi Ono, Priti Shah, Y. Omura, Yoshiki Tsunesada, Tsubasa Yoshioka, Daisuke Ikeda, Masahiro Takeda, Tiffany Wong, Mikhail Kuznetsov, Ken Honda, K. H. Lee, Jihee Kim, Kenta Yashiro, Gordon Thomson, Hideyuki Ohoka, Yuichiro Tameda, Yukio Uchihori, Masaki Fukushima, Hiroyuki Sagawa, R. Sahara, Charlie Jui, Jyunsei Chiba, Dongsu Ryu, Tom Stroman, Fugo Yoshida, Robert Cady, Ryota Onogi, J. H. Kim, Shinnosuke Kurisu, Shingo Kawana, Ryota Fujiwara, BayarJon Paul Lubsandorzhiev, William Hanlon, Hirokazu Iwakura, Y. Takagi, R. Mayta, Hiroyuki Matsumiya, Koichi Tanaka, Mayuko Minamino, Vladim Kuzmin, Hideaki Shimodaira, Ivan Kharuk, Jon Paul Lundquist, Naoto Sakaki, Youngjoon Kwon, Kinya Hibino, John Belz, Ryo Nakamura, Hyoming Jeong, Michiyuki Chikawa, Keitaro Fujita, Takafumi Uehama, Saori Kasami, Fumiya Shibata, Ryo Higuchi, Yuya Oku, M. Ohnishi, Takashi Sako, Masato Takita, Eiji Kido, Toshiyuki Nonaka, Taichi Inadomi, Oleg Kalashev, Ryosuke Tsuda, Soomin Jeong, Ricardo Gonzalez, Rasha Abbasi, Kazuhiro Machida, Toshio Matsuyama, Min Hyo Kim, Matt Potts, Koki Sato, Kengo Sano, K. Yamazaki, Tareq Abu-Zayyad, Hideki Tanaka, Zach Zundel, S. Kawakami, Yasunori Saito, Peter Tinyakov, Samuel Blake, Shoichi Ogio, Shigeharu Udo, T. Seki, Toru Nakamura, Naoya Inoue, Jeremy Smith, John Matthews, J. Yang, Monica Allen, Kenichi Kadota, Hisono Tokuno, Yuta Tanoue, Akimichi Taketa, Bokkyun Shin, Eiji Nishio, Il Hung Park, Motoki Hayashi, Ben Stokes, Kozo Fujisue, Heungsu Shin, Federico R. Urban, Nobuyuki Sakurai, Hideyuki Kawai, Yuma Shibasaki, Koichi Sekino, Yuto Arai, Douglas Bergman, Tatsunobu Shibata, Y. Takahashi, Mai Takamura, Akitoshi Oshima, Shunsuke Ozawa, Maxim Pshirkov, Fumio Kakimoto, Sergey Troitsky, Taka Tomida, J. Remington, Naoaki Hayashida, Toshihiro Fujii, Yuto Kubota, Y. Nakamura, Kohei Yada, Elliott Barcikowski, Dmitri Ivanov, Keijiro Mukai, Yusuke Kimura, Stanton Thomas, Aoi Iwasaki, Tomoyuki Nakamura, Ryuji Takeishi, Pierre Sokolsky, Shigehiro Nagataki, Yana Zhezher, Isaac Myers, Sang Woo Kim, Hirotaka Ito, G. Furlich, Takaaki Ishii, D. C. Rodriguez, HangBae Kim, Arata Nakazawa, and Kei Nakai

Subjects
Telescope, Physics, law, Astrophysics, Mass composition, Anisotropy, law.invention
Published
2021
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38. Analysis of TAx4 hybrid trigger and events

Author

Ivan Kharuk, Yuma Shibasaki, Jyunsei Chiba, Dongsu Ryu, Aoi Iwasaki, Hirokazu Iwakura, Y. Takagi, K. H. Lee, Jihee Kim, Ryota Fukushima, Ryuhei Arimura, Shigeharu Udo, Fumiya Shibata, Gordon Thomson, Hideki Tanaka, Fugo Yoshida, Tom Stroman, Robert Cady, Yoshiki Tsunesada, Sergey Troitsky, Daisuke Ikeda, Douglas Bergman, Taka Tomida, J. Remington, Tiffany Wong, John Matthews, ByongGu Cheon, Hiroyuki Matsumiya, Ryo Nakamura, Ryuji Takeishi, Masaki Fukushima, Hisono Tokuno, Ryosuke Tsuda, Soomin Jeong, M. Yamamoto, J. Yang, Matt Potts, Pierre Sokolsky, Min Hyo Kim, Yukio Uchihori, Naoaki Hayashida, Takashi Sako, T. Seki, Shigehiro Nagataki, Yana Zhezher, Akimichi Taketa, Naoya Inoue, Tatsunobu Shibata, Daiki Shinto, Sang Woo Kim, Eiji Nishio, Ryota Onogi, J. H. Kim, Priti Shah, Takafumi Uehama, G. Furlich, Takaaki Ishii, Saori Kasami, Hideaki Shimodaira, Hyoming Jeong, Masahiro Takeda, Charlie Jui, Ken Honda, R. Mayta, S. Kawakami, Heungsu Shin, BayarJon Paul Lubsandorzhiev, Ryo Higuchi, Toru Nakamura, Yuta Tanoue, Mayuko Minamino, Kenichi Kadota, Zach Zundel, Akitoshi Oshima, Eiji Kido, Elliott Barcikowski, Shingo Kawana, Shoichi Kishigami, Yuto Arai, Keitaro Fujita, Motoki Hayashi, Yuichiro Tameda, Hideyuki Ohoka, Il Hung Park, Kinya Hibino, Hirotaka Ito, Toshio Matsuyama, Kazuhiro Machida, Hiroyuki Sagawa, Hideyuki Kawai, D. C. Rodriguez, Dmitri Ivanov, Vladim Kuzmin, William Hanlon, Stanton Thomas, HangBae Kim, Shinnosuke Kurisu, Kozo Fujisue, Keijiro Mukai, K. Yamazaki, Masaomi Ono, Michiyuki Chikawa, Tareq Abu-Zayyad, Yusuke Kimura, Yasunori Saito, Koichi Tanaka, Grigory Rubtsov, Tomoyuki Nakamura, Jon Paul Lundquist, Koichi Sekino, Shunsuke Ozawa, Yuya Oku, P. Tinyakov, Isaac Myers, Oleg Kalashev, Masato Takita, Y. Takahashi, Mai Takamura, R. Sahara, Telescope Array, S. W. Kim, Manobu Tanaka, Toshiyuki Nonaka, Jeremy Smith, Norimichi Shibata, Y. Omura, Mikhail Kuznetsov, Ricardo Gonzalez, Ben Stokes, Samuel Blake, Toshihiro Fujii, Monica Allen, Shoichi Ogio, Yuto Kubota, Bokkyun Shin, Y. Nakamura, Kohei Yada, Federico R. Urban, Arata Nakazawa, Nobuyuki Sakurai, Kei Nakai, Youngjoon Kwon, John Belz, Rasha Abbasi, M. Ohnishi, Taichi Inadomi, Koki Sato, Fumio Kakimoto, Ryota Fujiwara, Kengo Sano, Naoto Sakaki, Katsuaki Kasahara, Katsumasa Kawata, Kenta Yashiro, Tsubasa Yoshioka, Maxim Pshirkov, Takeshi Okuda, Igor Tkachev, Naohiro Sone, and H. Oda

Published
2021
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39. Reconstruction of air shower events measured by the surface detectors of the TAx4 experiment

Author

Fugo Yoshida, Fumio Kakimoto, Norimichi Shibata, Kinya Hibino, John Matthews, J. Yang, Y. Omura, Ivan Kharuk, Toshihiro Fujii, Hiroyuki Sagawa, Yuichiro Tameda, Hideki Tanaka, Yuma Shibasaki, Yuto Kubota, Hisono Tokuno, Mikhail Kuznetsov, Katsuaki Kasahara, Koichi Tanaka, Jon Paul Lundquist, M. Yamamoto, Katsumasa Kawata, Monica Allen, Bokkyun Shin, Hiroyuki Matsumiya, Tsubasa Yoshioka, Takafumi Uehama, Y. Nakamura, Kohei Yada, Yukio Uchihori, Hyomin Jeong, Tatsunobu Shibata, Ryota Onogi, J. H. Kim, Michiyuki Chikawa, ByongGu Cheon, Hideaki Shimodaira, Hyoming Jeong, Eiji Kido, M. Ohnishi, Taichi Inadomi, Kazuhiro Machida, Ryo Higuchi, Charlie Jui, Akitoshi Oshima, R. Mayta, Douglas Bergman, Keitaro Fujita, Elliott Barcikowski, Maxim Pshirkov, Manobu Tanaka, Pierre Sokolsky, Vladim Kuzmin, BayarJon Paul Lubsandorzhiev, Shunsuke Ozawa, Min Hyo Kim, Dmitri Ivanov, Koki Sato, Mayuko Minamino, Saori Kasami, Shigehiro Nagataki, Hideyuki Ohoka, Takashi Sako, K. Yamazaki, Tareq Abu-Zayyad, Keijiro Mukai, Youngjoon Kwon, Yasunori Saito, John Belz, Yana Zhezher, Sang Woo Kim, S. Kawakami, Jyunsei Chiba, Ryo Nakamura, Masato Takita, Yusuke Kimura, Daiki Shinto, Dongsu Ryu, Yuta Tanoue, Fumiya Shibata, Yuya Oku, K. H. Lee, Jihee Kim, Kengo Sano, Priti Shah, Hirokazu Iwakura, Y. Takagi, Motoki Hayashi, Oleg Kalashev, Kenta Yashiro, Zach Zundel, Masahiro Takeda, Ken Honda, Ben Stokes, Matt Potts, Kozo Fujisue, Stanton Thomas, Gordon Thomson, Toshiyuki Nonaka, Ryuhei Arimura, Ryosuke Tsuda, Akimichi Taketa, Tom Stroman, Robert Cady, Soomin Jeong, Ricardo Gonzalez, Federico R. Urban, Nobuyuki Sakurai, Koichi Sekino, Yoshiki Tsunesada, P. Tinyakov, Daisuke Ikeda, Eiji Nishio, T. Seki, Tomoyuki Nakamura, Ryota Fukushima, Naoya Inoue, Tiffany Wong, Toru Nakamura, Kenichi Kadota, Y. Takahashi, Mai Takamura, Masaki Fukushima, Takeshi Okuda, Igor Tkachev, Shingo Kawana, Naohiro Sone, Heungsu Shin, William Hanlon, H. Oda, Il Hung Park, G. Furlich, Takaaki Ishii, Hideyuki Kawai, Shinnosuke Kurisu, Yuto Arai, Toshio Matsuyama, Samuel Blake, Shoichi Ogio, Jeremy Smith, D. C. Rodriguez, Aoi Iwasaki, HangBae Kim, Ryota Fujiwara, Naoto Sakaki, Grigory Rubtsov, Rasha Abbasi, R. Sahara, Arata Nakazawa, Kei Nakai, Telescope Array, Isaac Myers, Hirotaka Ito, Ryuji Takeishi, Shoichi Kishigami, Masaomi Ono, Sergey Troitsky, Taka Tomida, J. Remington, Naoaki Hayashida, and Shigeharu Udo

Subjects
Surface (mathematics), Materials science, Optics, Air shower, business.industry, Detector, business
Published
2021
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40. Creation of X-linked Alport Syndrome Rat Model with Col4a5 Deficiency

Author

Masaki Fukushima, Mayumi Kohno, Takayuki Koyano, Masumi Namba, Makoto Matsuyama, Tomoe Kobayashi, and Takuo Hirose

Subjects
Pathology, medicine.medical_specialty, Proteinuria, medicine.diagnostic_test, business.industry, Glomerular basement membrane, Mutant, Hyperplasia, urologic and male genital diseases, medicine.disease, Immunofluorescence, Type IV collagen, medicine.anatomical_structure, Knockout mouse, Medicine, Alport syndrome, medicine.symptom, business
Abstract

SummaryAlport syndrome is an inherited chronic human kidney disease, characterized by glomerular basement membrane abnormalities. This disease is caused by mutations in COL4A3, COL4A4, or COL4A5 gene. The knockout mice for Col4α3, Col4α4, and Col4α5 are developed and well characterized for the study of Alport syndrome. However, disease progression and effects of pharmacological therapy depend on the genetic variability. This model is reliable only to mice. Therefore in this study, we created a novel Alport syndrome rat model utilizing rGONAD technology. Col4α5 deficient rats showed hematuria, proteinuria, high levels of BUN, Cre, and then died at 18 to 28 weeks of age (Hemizygous mutant males). Histological and ultrastructural analyses displayed the abnormalities including parietal cell hyperplasia, mesangial sclerosis, and interstitial fibrosis. Then, we demonstrated that α3/α4/α5 (IV) and α5/α5/α6 (IV) chains of type IV collagen disrupted in the Col4α5 deficient rats. Moreover, immunofluorescence analyses revealed that some glomeruli of Col4α5 mutant rats were found to be disrupted from postnatal day 0. Thus, Col4α5 mutant rat is a reliable candidate for Alport syndrome model for underlying the mechanism of renal diseases and further identifying potential therapeutic targets for human renal diseases.

Published
2021
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41. Observations of the Origin of Downward Terrestrial Gamma‐Ray Flashes

Author

Hideaki Shimodaira, Hyoming Jeong, Hidemi Ito, N. Inoue, Takashi Sako, D. Ikeda, M. Ohnishi, Taichi Inadomi, Tareq Abu-Zayyad, Takayuki Tomida, Toru Nakamura, Federico R. Urban, Yuya Oku, Oleg Kalashev, Fumiya Shibata, Kenichi Kadota, S. Udo, C. C. H. Jui, Pierre Sokolsky, M. Takeda, Zach Zundel, Shigehiro Nagataki, Sergey Troitsky, Toshiyuki Nonaka, M. Byrne, Kengo Sano, R. Sahara, Matt Potts, K. H. Lee, Yasunori Saito, Hiroyuki Sagawa, Ben Stokes, T.-A. Shibata, Heungsu Shin, S. B. Thomas, H. Tokuno, H. Yamaoka, Yuta Tanoue, Motoki Hayashi, J. P. Lundquist, Gordon Thomson, Tom Stroman, Robert Cady, Kiyoshi Tanaka, Michiyuki Chikawa, J. Remington, Y. Hayashi, G. Furlich, Takaaki Ishii, Igor Tkachev, Naohiro Sone, Y. Zhezher, Yoshihiko Nakamura, Akimichi Taketa, J. D. Smith, T. Fujii, Keitaro Fujita, Y. J. Kwon, Hideyuki Ohoka, Vladim Kuzmin, H. Oda, K. Kawata, D. C. Rodriguez, S. Ozawa, BayarJon Paul Lubsandorzhiev, S. Jeong, B. K. Shin, D. Rodeheffer, Naoaki Hayashida, B. G. Cheon, T. Matuyama, Kenta Yashiro, Mayuko Minamino, M. Allen, Tiffany Wong, R. Takeishi, Yuichiro Tameda, Isaac Myers, K. Honda, Ryota Fujiwara, John N. Matthews, John Belz, Elliott Barcikowski, K. Kasahara, Masaki Fukushima, Akitoshi Oshima, Fumio Kakimoto, Dmitri Ivanov, Naoto Sakaki, Paul R. Krehbiel, M. Yamamoto, Y. Takahashi, Keijiro Mukai, Masaomi Ono, Masato Takita, M. Wallace, K. Yamazaki, H. Kawai, Masaaki Tanaka, Nobuyuki Sakurai, S. Kawakami, Hiroyuki Matsumiya, Saori Kasami, A. Di Matteo, T. Seki, Takafumi Uehama, Y. Tsunesada, Maxim Pshirkov, R. Mayta, R. LeVon, Hongsu Kim, Y. Uchihori, Eiji Kido, Kei Nakai, M. V. Kuznetsov, Kazuhiro Machida, K. Sekino, William Hanlon, T. Okuda, Inkyu Park, Grigory Rubtsov, William Rison, D. R. Bergman, R. U. Abbasi, Peter Tinyakov, Samuel Blake, Shoichi Ogio, J. H. Kim, Y. Omura, Dongsu Ryu, Mark A. Stanley, Hirokazu Iwakura, Y. Takagi, Ryo Nakamura, Kazuo Saito, H. Yoshii, M. Yosei, and K. Hibino

Subjects
High Energy Astrophysical Phenomena (astro-ph.HE), Physics, Atmospheric Science, 010504 meteorology & atmospheric sciences, Conjunction (astronomy), Gamma ray, FOS: Physical sciences, Astrophysics, Electron, Radio atmospheric, 01 natural sciences, Lightning, High Energy Physics - Experiment, Physics - Atmospheric and Oceanic Physics, High Energy Physics - Experiment (hep-ex), Geophysics, Space and Planetary Science, Electric field, Atmospheric and Oceanic Physics (physics.ao-ph), Earth and Planetary Sciences (miscellaneous), Atmospheric electricity, Astrophysics - High Energy Astrophysical Phenomena, Cosmic-ray observatory, 0105 earth and related environmental sciences
Abstract

In this paper we report the first close, high-resolution observations of downward-directed terrestrial gamma-ray flashes (TGFs) detected by the large-area Telescope Array cosmic ray observatory, obtained in conjunction with broadband VHF interferometer and fast electric field change measurements of the parent discharge. The results show that the TGFs occur during strong initial breakdown pulses (IBPs) in the first few milliseconds of negative cloud-to-ground and low-altitude intracloud flashes, and that the IBPs are produced by a newly-identified streamer-based discharge process called fast negative breakdown. The observations indicate the relativistic runaway electron avalanches (RREAs) responsible for producing the TGFs are initiated by embedded spark-like transient conducting events (TCEs) within the fast streamer system, and potentially also by individual fast streamers themselves. The TCEs are inferred to be the cause of impulsive sub-pulses that are characteristic features of classic IBP sferics. Additional development of the avalanches would be facilitated by the enhanced electric field ahead of the advancing front of the fast negative breakdown. In addition to showing the nature of IBPs and their enigmatic sub-pulses, the observations also provide a possible explanation for the unsolved question of how the streamer to leader transition occurs during the initial negative breakdown, namely as a result of strong currents flowing in the final stage of successive IBPs, extending backward through both the IBP itself and the negative streamer breakdown preceding the IBP., Comment: Typo fixed and reference added. Manuscript is 36 pages. Supplemental Information is 42 pages. This paper is to be published in the Journal of Geophysical Research: Atmospheres. Online data repository: Open Science Framework DOI: 10.17605/OSF.IO/Z3XDA

Published
2020
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43. Gamma Ray Showers Observed at Ground Level in Coincidence With Downward Lightning Leaders

Author

Fumiya Shibata, R. W. Springer, Maxim Pshirkov, John Belz, Akitoshi Oshima, Hiroyuki Sagawa, Fumio Kakimoto, D. R. Bergman, Zach Zundel, K. Hibino, Koichi Sekino, K. Kasahara, Y. Tsunesada, Hideaki Shimodaira, Ryo Nakamura, R. LeVon, Hongsu Kim, Kazuo Saito, Shoichi Kishigami, Heungsu Shin, Shunsuke Ozawa, Mayuko Minamino, K. Honda, Hidemi Ito, K. Martens, Toshitsugu Fujii, M. Yamamoto, Y. Yoneda, N. Inoue, G. Vasiloff, Ryuji Takeishi, Masato Takita, Nobuyuki Sakurai, Masaomi Ono, Priti Shah, Hideki Tanaka, Grigory Rubtsov, M. Ohnishi, H. Yoshii, Ryota Onogi, Ben Stokes, Daisuke Ikeda, Elliott Barcikowski, Sergey Troitsky, Masaaki Tanaka, T. Matuyama, Vladim Kuzmin, Jyunsei Chiba, Dongsu Ryu, M. Allen, Helio Takai, Takayuki Tomida, Dmitri Ivanov, Tiffany Wong, B. G. Cheon, Keijiro Mukai, S. Jeong, Masaki Fukushima, B. K. Shin, K. Oki, Federico R. Urban, J. Remington, S. Udo, C. C. H. Jui, Tareq Abu-Zayyad, R. Yamane, Peter Tinyakov, Samuel Blake, Shoichi Ogio, Rasha Abbasi, William Rison, H. Kawai, Michiyuki Chikawa, M. Byrne, Naoaki Hayashida, S. Kawakami, Kiyoshi Tanaka, S. B. Thomas, Akimichi Taketa, Y. Hayashi, Toru Nakamura, K. Kawata, T. Seki, Kenichi Kadota, J. Lan, Igor Tkachev, R. Cady, J. P. Lundquist, G. Furlich, Takaaki Ishii, D. Rodeheffer, Toshiyuki Nonaka, T.-A. Shibata, Gordon Thomson, S. Yoshida, Hiroshi Yamaoka, Tom Stroman, Naoto Sakaki, Kenta Yashiro, D. C. Rodriguez, Isaac Myers, Inkyu Park, Y. Uchihori, H. Tokuno, K. Yamazaki, J. D. Smith, Yuichiro Tameda, John N. Matthews, William Hanlon, T. Okuda, J. H. Kim, J. Yang, Y. J. Kwon, Hideyuki Ohoka, Paul R. Krehbiel, T. Goto, Eiji Kido, Pierre Sokolsky, Kazuhiro Machida, M. Takeda, Shigehiro Nagataki, R. J. Thomas, and O. Kalashev

Subjects
Atmospheric Science, 010504 meteorology & atmospheric sciences, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, Astrophysics, Radiation, 01 natural sciences, High Energy Physics - Experiment, law.invention, Telescope, High Energy Physics - Experiment (hep-ex), Electron avalanche, law, 0103 physical sciences, Earth and Planetary Sciences (miscellaneous), Cosmic-ray observatory, 010303 astronomy & astrophysics, 0105 earth and related environmental sciences, High Energy Astrophysical Phenomena (astro-ph.HE), Physics, Lightning detection, Astrophysics::Instrumentation and Methods for Astrophysics, Gamma ray, Lightning, Physics - Atmospheric and Oceanic Physics, Geophysics, 13. Climate action, Space and Planetary Science, Atmospheric and Oceanic Physics (physics.ao-ph), Satellite, Astrophysics - High Energy Astrophysical Phenomena
Abstract

Bursts of gamma ray showers have been observed in coincidence with downward propagating negative leaders in lightning flashes by the Telescope Array Surface Detector (TASD). The TASD is a 700~square kilometer cosmic ray observatory located in southwestern Utah, U.S.A. In data collected between 2014 and 2016, correlated observations showing the structure and temporal development of three shower-producing flashes were obtained with a 3D lightning mapping array, and electric field change measurements were obtained for an additional seven flashes, in both cases co-located with the TASD. National Lightning Detection Network (NLDN) information was also used throughout. The showers arrived in a sequence of 2--5 short-duration ($\le$10~$\mu$s) bursts over time intervals of several hundred microseconds, and originated at an altitude of $\simeq$3--5 kilometers above ground level during the first 1--2 ms of downward negative leader breakdown at the beginning of cloud-to-ground lightning flashes. The shower footprints, associated waveforms and the effect of atmospheric propagation indicate that the showers consist primarily of downward-beamed gamma radiation. This has been supported by GEANT simulation studies, which indicate primary source fluxes of $\simeq$$10^{12}$--$10^{14}$ photons for $16^{\circ}$ half-angle beams. We conclude that the showers are terrestrial gamma-ray flashes (TGFs), similar to those observed by satellites, but that the ground-based observations are more representative of the temporal source activity and are also more sensitive than satellite observations, which detect only the most powerful TGFs.

Published
2018
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45. The bursts of high energy events observed by the telescope array surface detector

Author

Hiroshi Yamaoka, T. Suzawa, Robert M. Anderson, Hideaki Shimodaira, Isaac Myers, M. Abe, Kenta Yashiro, T. Goto, Elliott Barcikowski, Dmitri Ivanov, Keijiro Mukai, Maxim Pshirkov, Sergey Troitsky, A. L. Sampson, Takaaki Ishii, Kanako Yamazaki, Priti Shah, K. Tsutsumi, S. Kitamura, Fumiya Shibata, D. C. Rodriguez, Hidemi Ito, S. Kawakami, J. P. Lundquist, Keiji Saito, Igor Tkachev, R. Ishimori, John Belz, R. W. Springer, Pierre Sokolsky, Naoaki Hayashida, Akimichi Taketa, Ben Stokes, K. Oki, Koichi Sekino, H. Yoshii, Tareq Abu-Zayyad, R. Yamane, Federico R. Urban, Kiyoshi Tanaka, Y. Yoneda, N. Inoue, M. Ohnishi, Michiyuki Chikawa, Hiroyuki Sagawa, R. Zollinger, S. Udo, C. C. H. Jui, Heungsu Shin, M. Takeda, Shigehiro Nagataki, Ryuji Takeishi, Akitoshi Oshima, Y. Uchihori, Y. J. Kwon, Hideyuki Ohoka, K. Nagasawa, S. B. Thomas, Tomohiro Matsuda, H. Kawai, Mai Takamura, T.-A. Shibata, Fumio Kakimoto, Peter Tinyakov, Gordon Thomson, K. Hibino, Samuel Blake, Byung Gu Cheon, Tom Stroman, Robert Cady, Shoichi Ogio, Zach Zundel, Hang Bae Kim, G. Vasiloff, L. M. Scott, J. Ogura, K. Martens, Hideki Tanaka, Jyunsei Chiba, Dongsu Ryu, B. K. Shin, Takayuki Tomida, Masato Takita, Mayuko Minamino, K. Honda, Yasunori Kitamura, Rasha Abbasi, A. Nozato, Y. Hayashi, Yoshiki Tsunesada, Daisuke Ikeda, M. Allen, Inkyu Park, S. R. Stratton, K. Kawata, Masaaki Tanaka, Nobuyuki Sakurai, Tiffany Wong, Masaki Fukushima, Douglas Bergman, Takahiro Fujii, V. Kuzmin, Ryota Onogi, J. H. Kim, S. Yoshida, Naoto Sakaki, O. Kalashev, Toru Nakamura, Eiji Kido, Kazuhiro Machida, Kenichi Kadota, T. Matsuyama, S. Ozawa, Yasunori Saito, K. Kasahara, Shoichi Kishigami, R. Azuma, Yuichiro Tameda, John N. Matthews, Masaomi Ono, G. Rubtsov, Shingo Kawana, William Hanlon, T. Okuda, J. Yang, H. Tokuno, J. D. Smith, J. Lan, and Toshiyuki Nonaka

Subjects
Physics, 010504 meteorology & atmospheric sciences, Gamma ray, General Physics and Astronomy, Astronomy, Cosmic ray, Astrophysics, 01 natural sciences, Lightning, Particle detector, law.invention, Telescope, Air shower, law, 0103 physical sciences, Ultra-high-energy cosmic ray, 010306 general physics, 0105 earth and related environmental sciences, Terrestrial gamma-ray flash
Abstract

The Telescope Array (TA) experiment is designed to detect air showers induced by ultra high energy cosmic rays. The TA ground Surface particle Detector (TASD) observed several short-time bursts of air shower like events. These bursts are not likely due to chance coincidence between single shower events. The expectation of chance coincidence is less than 10 − 4 for five-year's observation. We checked the correlation between these bursts of events and lightning data, and found evidence for correlations in timing and position. Some features of the burst events are similar to those of a normal cosmic ray air shower, and some are not. On this paper, we report the observed bursts of air shower like events and their correlation with lightning.

Published
2017
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46. Search for Large-scale Anisotropy on Arrival Directions of Ultra-high-energy Cosmic Rays Observed with the Telescope Array Experiment

Author

Takashi Sako, Hideaki Shimodaira, Hyoming Jeong, Ryo Higuchi, Inkyu Park, Kenta Yashiro, R. U. Abbasi, Tareq Abu-Zayyad, R. Azuma, Fumiya Shibata, F. Kakimoto, R. Ishimori, Daisuke Ikeda, K. Yamazaki, H. Kawai, Tiffany Wong, R. Takeishi, Masaki Fukushima, Maxim Pshirkov, Hongsu Kim, B. K. Shin, Hideki Tanaka, Toshiyuki Fujii, B. G. Cheon, T. Seki, John Belz, K. Kawata, BayarJon Paul Lubsandorzhiev, Akimichi Taketa, Min Hyo Kim, G. Furlich, Takaaki Ishii, Mayuko Minamino, K. Honda, Takayuki Tomida, Seok Ho Jeong, K. H. Lee, Yuta Tanoue, Masaaki Tanaka, D. C. Rodriguez, T.-A. Shibata, S. Kawakami, Motoki Hayashi, Zach Zundel, Peter Tinyakov, Samuel Blake, Gordon Thomson, Ben Stokes, Tom Stroman, Robert Cady, J. P. Lundquist, Shoichi Ogio, Kozo Fujisue, Hiroyuki Sagawa, M. Yamamoto, M. Yosei, Hidemi Ito, Grigory Rubtsov, Koichi Sekino, Kiyoshi Tanaka, D. R. Bergman, T. Suzawa, Y. Zhezher, Heungsu Shin, Isaac Myers, Katsuaki Kasahara, Y. Takahashi, Mai Takamura, Nobuyuki Sakurai, Yuya Oku, Oleg Kalashev, K. Hibino, Shoichi Kishigami, M. Allen, Sergey Troitsky, Toru Nakamura, Kenichi Kadota, T. Matsuyama, S. Ozawa, Masaomi Ono, Toshiyuki Nonaka, Y. Uchihori, Kei Nakai, Ryota Onogi, A. Di Matteo, J. Remington, Hideyuki Ohoka, R. Mayta, Vladim Kuzmin, Ryota Fujiwara, Keitaro Fujita, Saori Kasami, Shingo Kawana, Naoto Sakaki, Naoaki Hayashida, Yoshihiko Nakamura, William Hanlon, Priti Shah, T. Okuda, J. Yang, Masato Takita, R. Sahara, Pierre Sokolsky, M. Takeda, Shigehiro Nagataki, M. Abe, Akitoshi Oshima, Y. Tsunesada, H. Tokuno, Younghoon Kwon, J. D. Smith, J. H. Kim, Elliott Barcikowski, Dmitri Ivanov, Keijiro Mukai, Jyunsei Chiba, Dongsu Ryu, Hirokazu Iwakura, Y. Takagi, Kohei Yada, Y. Omura, Igor Tkachev, Naohiro Sone, H. Oda, N. Inoue, M. Ohnishi, Taichi Inadomi, Federico R. Urban, S. Udo, C. C. H. Jui, Kengo Sano, S. B. Thomas, Yasunori Saito, Yuichiro Tameda, John N. Matthews, S. W. Kim, Hiroyuki Matsumiya, M. Chikawa, Takafumi Uehama, Eiji Kido, M. V. Kuznetsov, Kazuhiro Machida, and Ryo Nakamura

Subjects
Physics, Pierre Auger Observatory, High Energy Astrophysical Phenomena (astro-ph.HE), 010504 meteorology & atmospheric sciences, Astrophysics::High Energy Astrophysical Phenomena, Astrophysics::Instrumentation and Methods for Astrophysics, FOS: Physical sciences, Astronomy and Astrophysics, Cosmic ray, 01 natural sciences, Auger, Computational physics, law.invention, Telescope, Dipole, Amplitude, Space and Planetary Science, law, 0103 physical sciences, Ultra-high-energy cosmic ray, Astrophysics - High Energy Astrophysical Phenomena, Anisotropy, 010303 astronomy & astrophysics, 0105 earth and related environmental sciences
Abstract

Motivated by the detection of a significant dipole structure in the arrival directions of ultrahigh-energy cosmic rays above 8 EeV reported by the Pierre Auger Observatory (Auger), we search for a large-scale anisotropy using data collected with the surface detector array of the Telescope Array Experiment (TA). With 11 years of TA data, a dipole structure in a projection of the right ascension is fitted with an amplitude of 3.3+- 1.9% and a phase of 131 +- 33 degrees. The corresponding 99% confidence-level upper limit on the amplitude is 7.3%. At the current level of statistics, the fitted result is compatible with both an isotropic distribution and the dipole structure reported by Auger., Comment: 6 pages, 3 figures, 1 table, Proofed title. Added journal reference and DOI

Published
2020
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47. Long-term Successful Treatment of Rituximab for Steroid-resistant Minimal Change Nephrotic Syndrome and Idiopathic Thrombocytopenic Purpura

Author

Haruka Ikuta, Kosuke Fukuoka, Motoko Kanzaki, Tomohiro Kawazoe, Ryo Sawaki, Masaki Fukushima, Noriaki Shimada, Mana Nishikawa, and Kenichiro Asano

Subjects
Adult, medicine.medical_specialty, regulatory T cell, Nephrotic Syndrome, medicine.medical_treatment, Splenectomy, Case Report, Gastroenterology, Young Adult, Antineoplastic Agents, Immunological, rituximab, immune system diseases, Internal medicine, hemic and lymphatic diseases, minimal change nephrotic syndrome, Internal Medicine, medicine, Humans, Purpura, Thrombocytopenic, Idiopathic, business.industry, Complete remission, General Medicine, medicine.disease, Steroid resistant, Thrombocytopenic purpura, Treatment Outcome, idiopathic thrombocytopenic purpura, Prednisolone, Minimal change nephrotic syndrome, Rituximab, Female, business, medicine.drug
Abstract

A 22-year-old woman had been diagnosed with idiopathic thrombocytopenic purpura (ITP) 5 years earlier. After undergoing splenectomy, she relapsed frequently following prednisolone tapering. She was complicated with minimal change nephrotic syndrome (MCNS) while taking 20 mg of prednisolone. Despite treatment with prednisolone, cyclosporin and low-density lipoprotein-apheresis, MCNS and ITP did not improve. We added rituximab in 4 weekly infusions of 375 mg/m2. MCNS and ITP were in complete remission. After administering rituximab once, all medicines were discontinued. No relapse had occurred by 50 months following the first rituximab administration. Rituximab affects steroid-resistant MCNS and ITP for a long time without complications.

Published
2019

48. Search for Ultra-High-Energy Neutrinos with the Telescope Array Surface Detector

Author

Koichi Sekino, Y. Takahashi, Mai Takamura, S. Kitamura, Hidemi Ito, K. Martens, Yuta Tanoue, Motoki Hayashi, J. P. Lundquist, K. Tsutsumi, John Belz, Heungsu Shin, Vladim Kuzmin, Takashi Sako, Toru Nakamura, Inkyu Park, Kenichi Kadota, Yana Zhezher, Hiroyuki Sagawa, D. R. Bergman, Maxim Pshirkov, Charlie Jui, BayarJon Paul Lubsandorzhiev, Mayuko Minamino, K. Yamazaki, M. Abe, K. H. Lee, K. Honda, Daisuke Ikeda, S. R. Stratton, Yasunori Kitamura, T.-A. Shibata, Gordon Thomson, Toshiyuki Fujii, Ryo Nakamura, Tom Stroman, Robert Cady, Masaaki Tanaka, Fumiya Shibata, M. Yamamoto, Nobuyuki Sakurai, Tiffany Wong, R. Takeishi, L. M. Scott, Hongsu Kim, Y. Hayashi, R. Ishimori, Masaki Fukushima, Kazuo Saito, Ben Stokes, N. Inoue, M. Ohnishi, Y. J. Kwon, Akimichi Taketa, Eiji Kido, B. G. Cheon, H. Kawai, K. Kawata, Federico R. Urban, M. V. Kuznetsov, Ryota Onogi, Hideyuki Ohoka, Pierre Sokolsky, A. Di Matteo, H. Yoshii, S. Udo, Kazuhiro Machida, Hideaki Shimodaira, Hyoming Jeong, M. Takeda, Shigehiro Nagataki, R. Mayta, T. Seki, Seok Ho Jeong, S. B. Thomas, Peter Tinyakov, Samuel Blake, Oleg Kalashev, Shoichi Ogio, Priti Shah, Igor Tkachev, Zach Zundel, S. Kawakami, Fumio Kakimoto, Tareq Abu-Zayyad, K. Nagasawa, H. Oda, H. Tokuno, R. Azuma, Toshiyuki Nonaka, K. Hibino, Kenta Yashiro, Akitoshi Oshima, Y. Tsunesada, Keitaro Fujita, B. K. Shin, H. Yamaoka, Michiyuki Chikawa, Masato Takita, J. D. Smith, Sergey Troitsky, Y. Omura, J. Remington, J. H. Kim, Elliott Barcikowski, Dmitri Ivanov, Jyunsei Chiba, Keijiro Mukai, Naoaki Hayashida, Shingo Kawana, Dongsu Ryu, Y. Takagi, Yasunori Saito, William Hanlon, T. Okuda, J. Yang, Yuichiro Tameda, John N. Matthews, Kohei Yada, Hideki Tanaka, Takayuki Tomida, K. Kasahara, Shoichi Kishigami, Kiyoshi Tanaka, Grigory Rubtsov, M. Allen, Masaomi Ono, R. Sahara, Ryota Fujiwara, Naoto Sakaki, Y. Uchihori, Kei Nakai, Rasha Abbasi, T. Matsuyama, S. Ozawa, T. Suzawa, J. Ogura, Isaac Myers, G. Furlich, Takaaki Ishii, and D. C. Rodriguez

Subjects
High Energy Astrophysical Phenomena (astro-ph.HE), Physics, business.industry, Astrophysics::High Energy Astrophysical Phenomena, Detector, FOS: Physical sciences, General Physics and Astronomy, Flux, Observable, Cosmic ray, 01 natural sciences, law.invention, Telescope, Optics, Distribution function, law, 0103 physical sciences, Alternating decision tree, High Energy Physics::Experiment, Neutrino, 010306 general physics, business, Astrophysics - High Energy Astrophysical Phenomena
Abstract

We present an upper limit on the flux of ultra-high-energy down-going neutrinos for $E > 10^{18}\ \mbox{eV}$ derived with the nine years of data collected by the Telescope Array surface detector (05-11-2008 -- 05-10-2017). The method is based on the multivariate analysis technique, so-called Boosted Decision Trees (BDT). Proton-neutrino classifier is built upon 16 observables related to both the properties of the shower front and the lateral distribution function., 10 pages, 4 figures, accepted to JETP

Published
2019

49. Impaired mental health status in patients with chronic kidney disease is associated with estimated glomerular filtration rate decline

Author

Kenichiro Asano, Hidemi Takeuchi, Yuki Kakio, Jun Wada, Hironobu Tokumasu, Masaki Fukushima, Hitoshi Sugiyama, Noriaki Shimada, Yasuhiro Onishi, and Haruhito A. Uchida

Subjects
Adult, Male, Nephrology, medicine.medical_specialty, Health Status, Emotions, 030232 urology & nephrology, Renal function, Disease, 030204 cardiovascular system & hematology, Kidney, urologic and male genital diseases, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Quality of life, Internal medicine, medicine, Humans, Renal Insufficiency, Chronic, Social Behavior, Aged, Proportional hazards model, business.industry, Hazard ratio, General Medicine, Middle Aged, medicine.disease, Mental health, humanities, Mental Health, Quality of Life, Female, business, Glomerular Filtration Rate, Kidney disease
Abstract

Aim Deteriorated health-related quality of life (HRQOL) is associated with increased risk for death in both chronic kidney disease (CKD) and end-stage renal disease (ESRD) patients; however, the impact of HRQOL on CKD progression is not well investigated. Methods We aimed to evaluate the association between HRQOL and CKD progression in Japanese patients with CKD. One hundred and three outpatients who visited the department of nephrology at our hospital (mean estimated glomerular filtration rate (eGFR); 32.1 ± 11.2 mL/min per 1.73 m2 ) between April 2007 and March 2012 were enrolled in this study. The primary outcome was 30% decline of eGFR or ESRD. We assessed HRQOL of all participants at baseline, including the physical component summary (PCS), the mental component summary (MCS) and the role/social component summary (RCS), using SF-36. Based on the baseline score of PCS, MCS and RCS, we divided all subjects into two groups by median. Results We studied 66 men (64.1%) and 37 women aged 61.7 ± 10.0 years old. During approximately 2.5 years of follow-up period, 59 patients (57.3%) reached 30% eGFR decline or ESRD. Cox regression analyses demonstrated that lower MCS score was significantly associated with CKD progression (hazard ratio (HR) = 1.83, 95% CI = 1.04-3.21, P = 0.035), but that lower PCS score and RCS score were not (HR = 0.70, 95% CI = 0.39-1.25, P = 0.223; HR = 0.95, 95% CI = 0.54-1.67, P = 0.854, respectively). Conclusion We found that impaired mental health was associated with CKD progression. The evaluation of the mental health should be performed in the patients with CKD.

Published
2019
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50. The p21 dependent G2 arrest of the cell cycle in epithelial tubular cells links to the early stage of renal fibrosis

Author

Masumi Namba, Takayuki Koyano, Kyomi Nakakuni, Daisuke Nakano, Tomoe Kobayashi, Makoto Matsuyama, Masaki Fukushima, and Akira Nishiyama

Subjects
0301 basic medicine, Cyclin-Dependent Kinase Inhibitor p21, DNA damage, lcsh:Medicine, Fluorescent Antibody Technique, Severity of Illness Index, Article, Extracellular matrix, 03 medical and health sciences, Mice, 0302 clinical medicine, Fibrosis, Cyclin-dependent kinase, medicine, Renal fibrosis, Animals, lcsh:Science, Cell Proliferation, Kidney, Multidisciplinary, biology, Cell growth, business.industry, lcsh:R, DNA damage and repair, Wnt signaling pathway, Epithelial Cells, G2-M DNA damage checkpoint, Cell cycle, medicine.disease, G2 Phase Cell Cycle Checkpoints, 030104 developmental biology, medicine.anatomical_structure, Kidney Tubules, Mechanisms of disease, Cancer research, biology.protein, lcsh:Q, Kidney Diseases, Disease Susceptibility, business, Genetic techniques, 030217 neurology & neurosurgery, Biomarkers, Kidney disease, DNA Damage
Abstract

Renal fibrosis is accompanied with the progression of chronic kidney disease (CKD). Despite a number of past and ongoing studies, our understanding of the underlying mechanisms remains elusive. Here we explored the progression of renal fibrosis by using a mouse model, unilateral ureter obstruction (UUO). We found that in the initial stage of the progression where extracellular matrix did not deposit yet, the proximal tubular cells arrested at the G2 of the cell cycle. This G2 arrest was induced prior to activation of both DNA damage checkpoint and Wnt/β-Catenin pathway. Further analyses in vivo and in vitro indicated the cyclin dependent kinase inhibitor p21 is involved in the G2 arrest after the damage. The newly produced monoclonal antibody against p21 revealed that the p21 levels were sharply upregulated in response to the damage during the initial stage, but dropped down toward the later stage. To examine the function of p21 in the progression of renal fibrosis, we constructed the novel p21 deficient mice by i-GONAD. Compared with wild-type mice, p21 deficient mice showed the exacerbation of the fibrosis. Thus we propose that during the initial stage of the fibrosis following the renal damage, tubular cells arrest in the G2 phase depending on p21, thereby safeguarding the kidney functions.

Published
2019

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