Search

Phytochemical investigation of the petroleum ether and methylene chloride extracts of the stems of Euphorbia tithymaloides L. (Euphorbiaceae) afforded the triterpenes friedelane-3β-ol, 3-oxo-friedelane, euphane-7, 24-diene, 3β-ol (butyrospermol), and euphane -7, 25-diene, 3, 24-β-diols in addition to the diterpene derivative 1 a, 13 β, 14 a-trihydroxy-3 β, 7 β-dibenzenzoyloxy-9 β, 15 β-diacetoxyjatropha-5, 11-E-diene and the phytosterol β-sitosterol. The structures of the isolated compounds were established depend on spectroscopic and chemical evidences. The petroleum ether, methylene chloride, and methanolic extracts of the stems of E. tithymaliodes L. were tested in vitro by determining their action on oxidative stress status of rat liver homogenate for their hepatoprotective activity in addition, the pet ether extract was tested in vivo for its hepatoprotective activity and diterpene derivative was tested in vitro for cytotoxic activity. [ABSTRACT FROM AUTHOR]

Investigation of the aerial parts of Vernonia leopoldii (Sch. Bip.) Vatke afforded a new lanostane-type triterpene along with known hirsutinolide-type sesquiterpene lactones and flavonoid glycosides, all are identified for the first time in this species. The new compound was identified as lanost-3β, 23S-dihydroxy-22(31)-ene. The structures of the isolated compounds were elucidated based on spectroscopic evidence. The hirsutinolides and the triterpene were evaluated for their cytotoxicity against four human cancer cell lines using MTT assay. [ABSTRACT FROM AUTHOR]

Machaerium, in the family Fabaceae, predominantly is a genus of a Neotropical distribution of trees, shrubs, and lianas occurring from southern Mexico to Brazil and northern Argentina and as far as South America. Several Machaerium species are widely used in traditional medicine and are considered to have multiple medicinal properties. This review aims to provide up-to-date and comprehensive information on the taxonomy, phytochemistry, traditional uses and biological activities of plants in the genus Machaerium. [ABSTRACT FROM AUTHOR]

A new acylated kaempferol glycoside, kaempferol 3-O-α-l-rhamnopyranosyl-(1 → 6)-O-[β-d-glucopyranosyl-(1 → 2)-4-O-acetyl-α-l-rhamnopyranosyl-(1 → 2)]-β-d-galactopyranoside, has been isolated from the leaves ofTipuana tipu(Benth.) Lillo growing in Egypt, along with three known flavonol glycosides, kaempferol 3-O-rutinoside, quercetin 3-O-rutinoside (rutin) and kaempferol 3-O-[α-l-rhamnopyranosyl-(1 → 6)]-[α-l-rhamnopyranosyl-(1 → 2]-β-d-glucopyranoside. Structure elucidation was achieved through different spectroscopic methods. Structure relationship with anti-inflammatory activity using carrageenin-induced rat paw oedema model is discussed. [ABSTRACT FROM PUBLISHER]

Phytochemical investigation of Gomphocarpus fruticosus (L.) Ait. of Egyptian origin afforded the new pregnane glycoside lineolon-3-O-[β-D-oleandropyranosyl-(1-4)-β-D-cymaropyranosyl-(1-4)-β-D-cymaropyranoside], along with six known compounds. The structures of the isolated compounds were elucidated on the basis of extensive spectroscopic evidences derived from 1D, 2D NMR experiments, mass spectrometry and by comparing their physical and spectroscopic data to literature. These included the triterpenoids 3β-taraxerol, 3β-taraxerol acetate and betulinic acid, which are identified for the first time in G. fruticosus and the cardenolides uzarigenin, gomphoside and calotropin.