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Your search keyword '"Marzi, Ilaria"' showing total 22 results
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22 results on '"Marzi, Ilaria"'

1. Towards the Healthcare of the Future. A Delphi Consensus on Environmental Sustainability Issues

Author

Dal Mas, Francesca, Previtali, Pietro, Denicolai, Stefano, Alvaro, Matteo, Biancuzzi, Helena, Campostrini, Stefano, Cutti, Sara, Grancini, Giulia, Magnani, Giovanna, Re, Beatrice, Reali, Alessandro, Venturi, Alessandro, Ambrosio, Alberto Giovanni, Boscagli, Giacomo, Bruni, Gianlorenzo, Calogero, Giuseppe, Camerini, Gaia, Cannarozzo, Antonio, Cantoni, Rita, Casazzo, Teodoro, Casella, Claudio, Ceresetti, Gabriele, Di Bartolo, Giuseppe, Domimagni, Cristina, Grechi, Maria Francesca, Liggeri, Silvia, Marzi, Ilaria, Mauri, Milena, Moioli, Gianpietro, Morabito, Maria Concetta, Palazzo, Giovanni, Panizzoli, Giuseppina, Passarella, Sabrina, Paternoster, Marco, Raimondi, Lucio, Rottoli, Elisa Maria, Salzillo, Adelina, Schiavini, Paolo, Tallarita, Enrico Antonio, Vassena, Sara, Cobianchi, Lorenzo, Marini, Maria Giulia, Series Editor, McFarland, Jonathan, Series Editor, Boyce-Tillman, June, Editorial Board Member, Delorenzo, Christian, Editorial Board Member, Farkas, Carol-Ann, Editorial Board Member, Frey, Marco, Editorial Board Member, Messner, Angelika, Editorial Board Member, Vagnarelli, Federica, Editorial Board Member, Varsou, Ourania, Editorial Board Member, Vickers, Neil, Editorial Board Member, Martellucci, Jacopo, editor, and Dal Mas, Francesca, editor

Published
2023
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3. Endometrial Dysbiosis Is Related to Inflammatory Factors in Women with Repeated Implantation Failure: A Pilot Study

Author

Cela, Vito, primary, Daniele, Simona, additional, Obino, Maria Elena Rosa, additional, Ruggiero, Maria, additional, Zappelli, Elisa, additional, Ceccarelli, Lorenzo, additional, Papini, Francesca, additional, Marzi, Ilaria, additional, Scarfò, Giorgia, additional, Tosi, Fulvia, additional, Franzoni, Ferdinando, additional, Martini, Claudia, additional, and Artini, Paolo Giovanni, additional

Published
2022
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4. Exploring Epithelial–Mesenchymal Transition Signals in Endometriosis Diagnosis and In Vitro Fertilization Outcomes

Author

Cela, Vito, primary, Malacarne, Elisa, additional, Obino, Maria Elena Rosa, additional, Marzi, Ilaria, additional, Papini, Francesca, additional, Vergine, Francesca, additional, Pisacreta, Elena, additional, Zappelli, Elisa, additional, Pietrobono, Deborah, additional, Scarfò, Giorgia, additional, Daniele, Simona, additional, Franzoni, Ferdinando, additional, Martini, Claudia, additional, and Artini, Paolo Giovanni, additional

Published
2021
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14. Hypoxia-resistant profile implies vulnerability of cancer stem cells to physiological agents, which suggests new therapeutic targets

Author

Grazia Cipolleschi, Maria, primary, Marzi, Ilaria, additional, Santini, Roberta, additional, Fredducci, David, additional, Cristina Vinci, Maria, additional, D'Amico, Massimo, additional, Rovida, Elisabetta, additional, Stivarou, Theodora, additional, Torre, Eugenio, additional, Dello Sbarba, Persio, additional, Stecca, Barbara, additional, and Olivotto, Massimo, additional

Published
2013
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16. The involvement of a Nanog, Klf4 and c-Myc transcriptional circuitry in the intertwining between neoplastic progression and reprogramming

Author

Marzi, Ilaria, primary, Cipolleschi, Maria Grazia, additional, D'Amico, Massimo, additional, Stivarou, Theodora, additional, Rovida, Elisabetta, additional, Vinci, Maria Cristina, additional, Pandolfi, Silvia, additional, Dello Sbarba, Persio, additional, Stecca, Barbara, additional, and Olivotto, Massimo, additional

Published
2013
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20. Hypoxia-resistant profile implies vulnerability of cancer stem cells to physiological agents, which suggests new therapeutic targets

Author

Grazia Cipolleschi, Maria, Marzi, Ilaria, Santini, Roberta, Fredducci, David, Cristina Vinci, Maria, D'Amico, Massimo, Rovida, Elisabetta, Stivarou, Theodora, Torre, Eugenio, Dello Sbarba, Persio, Stecca, Barbara, and Olivotto, Massimo

Abstract

We have previously shown that peculiar metabolic features of cell adaptation and survival in hypoxia imply growth restriction points that are typical of embryonic stem cells and disappear with differentiation. Here we provide evidence that such restrictions can be exploited as specific antiblastic targets by physiological factors such as pyruvate, tetrahydrofolate, and glutamine. These metabolites act as powerful cytotoxic agents on cancer stem cells (CSCs) when supplied at doses that perturb the biochemical network, sustaining the resumption of aerobic growth after the hypoxic dormant state. Experiments were performed in vivo and in vitro using CSCs obtained from various anaplastic tumors: human melanoma, leukemia, and rat hepatoma cells. Pretreatment of melanoma CSCs with pyruvate significantly reduces their self-renewal in vitro and tumorigenicity in vivo. The metabolic network underlying the cytotoxic effect of the physiological factors was thoroughly defined, principally using AH130 hepatoma, a tumor spontaneously reprogrammed to the embryonic stem stage. This network, based on a tight integration of aerobic glycolysis, cellular redox state, and folate metabolism, is centered on the cellular NADP/NADPH ratio that controls the redox pathway of folate utilization in purine synthesis. On the whole, this study indicates that pyruvate, FH4, and glutamine display anticancer activity, because CSCs are committed to survive and maintain their stemness in hypoxia. When CSC need to differentiate and proliferate, they shift from anaerobic to aerobic status, and the few mitochondria available makes them susceptible to the injury of the above physiological factors. This vulnerability might be exploited for novel therapeutic treatments.

Published
2014
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21. One more stem cell niche: how the sensitivity of chronic myeloid leukemia cells to imatinib mesylate is modulated within a "hypoxic" environment.

Author

Rovida E, Marzi I, Cipolleschi MG, and Dello Sbarba P

Abstract

This is a review (by no means comprehensive) of how the stem cell niche evolved from an abstract concept to a complex system, implemented with a number of experimental data at the cellular and molecular levels, including metabolic cues, on which we focused in particular. The concept was introduced in 1978 to model bone marrow sites suited to host hematopoietic stem cells (HSCs) and favor their self-renewal, while restraining clonal expansion and commitment to differentiation. Studies of the effects of low oxygen tension on HSC maintenance in vitro led us to hypothesize niches were located within bone marrow areas where oxygen tension is lower than elsewhere. We named these areas hypoxic stem cell niches, although a low oxygen tension is to be considered physiological for the environment where HSCs are maintained. HSCs were later shown to have the option of cycling in low oxygen, which steers this cycling to the maintenance of stem cell potential. Cell subsets capable of withstanding incubation in very low oxygen were also detected within leukemia cell populations, including chronic myeloid leukemia (CML). The oncogenetic Bcr/Abl protein is completely suppressed in these subsets, whereas Bcr/Abl messenger ribonucleic acid is not, indicating that CML cells resistant to low oxygen are independent of Bcr/Abl for persistence in culture but remain genetically leukemic. Accordingly, leukemia stem cells of CML selected in low oxygen are refractory to the Bcr/Abl inhibitor imatinib mesylate. Bcr/Abl protein suppression turned out to be actually determined when glucose shortage complicated the effects of low oxygen, indicating that ischemia-like conditions are the driving force of leukemia stem cell refractoriness to imatinib mesylate. These studies pointed to "ischemic" stem cell niches as a novel scenario for the maintenance of minimal residual disease of CML. A possible functional relationship of the "ischemic" with the "hypoxic" stem cell niche is discussed.

Published
2014
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22. Cell renewing in neuroblastoma: electrophysiological and immunocytochemical characterization of stem cells and derivatives.

Author

Biagiotti T, D'Amico M, Marzi I, Di Gennaro P, Arcangeli A, Wanke E, and Olivotto M

Subjects
Antigens, Differentiation analysis, Cell Differentiation, Cell Line, Tumor, Cell Lineage, Cell Proliferation, Clone Cells, Electrophysiology, Humans, Immunohistochemistry, Models, Biological, Mutation, Patch-Clamp Techniques, Time Factors, Neural Crest physiology, Neuroblastoma pathology, Stem Cells chemistry, Stem Cells physiology
Abstract

We explored the stem cell compartment of the SH-SY5Y neuroblastoma (NB) clone and its development by a novel approach, integrating clonal and immunocytochemical investigations with patch-clamp measurements of ion currents simultaneously expressed on single cells. The currents selected were the triad IHERG, IKDR, INa, normally expressed at varying mutual ratios during development of neural crest stem cells, from which NB derives upon neoplastic transformation. These ratios could be used as electrophysiological clusters of differentiation (ECDs), identifying otherwise indistinguishable stages in maturation. Subcloning procedures allowed the isolation of highly clonogenic substrate-adherent (S-type) cells that proved to be p75- and nestinpositive and were characterized by a nude electrophysiological profile (ECDS0). These cells expressed negligible levels of the triad and manifested the capacity of generating the two following lineages: first, a terminally differentiating, smooth muscular lineage, positive for calponin and smooth muscle actin, whose electrophysiological profile is characterized by a progressive diminution of IHERG, the increase of IKDR and INa, and the acquisition of IKIR (ECDS2); second, a neuronal abortive pathway (NF-68 positive), characterized by a variable expression of IHERG and IKDR and a low expression of INa (ECDNS). This population manifested a vigorous amplification, monopolizing the stem cell compartment at the expense of the smooth muscular lineage to such an extent that neuronal-like (N-type) cells must be continuously removed if the latter are to develop.

Published
2006
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