Search

Your search keyword '"Marzano, Simona"' showing total 19 results
Start Over Author "Marzano, Simona"
19 results on '"Marzano, Simona"'

2. Theoretical and experimental studies on the interaction of biphenyl ligands with human and murine PD-L1: Up-to-date clues for drug design

Author

Donati, Greta, D’Amore, Vincenzo Maria, Russomanno, Pasquale, Cerofolini, Linda, Amato, Jussara, Marzano, Simona, Salobehaj, Maria, Rizzo, Domenico, Assoni, Giulia, Carotenuto, Alfonso, La Pietra, Valeria, Arosio, Daniela, Seneci, Pierfausto, Fragai, Marco, Brancaccio, Diego, Di Leva, Francesco Saverio, and Marinelli, Luciana

Published
2023
Full Text
View/download PDF

5. New biologic (Ab-IPL-IL-17) for IL-17-mediated diseases: identification of the bioactive sequence (nIL-17) for IL-17A/F function

Author

Saviano, Anella, primary, Manosour, Adel Abo, additional, Raucci, Federica, additional, Merlino, Francesco, additional, Marigliano, Noemi, additional, Schettino, Anna, additional, Wahid, Mussarat, additional, Begum, Jenefa, additional, Filer, Andrew, additional, Manning, Julia E, additional, Casillo, Gian Marco, additional, Piccolo, Marialuisa, additional, Ferraro, Maria Grazia, additional, Marzano, Simona, additional, Russomanno, Pasquale, additional, Bellavita, Rosa, additional, Irace, Carlo, additional, Amato, Jussara, additional, Alfaifi, Mohammed, additional, Rimmer, Peter, additional, Iqbal, Tariq, additional, Pieretti, Stefano, additional, Vellecco, Valentina, additional, Caso, Francesco, additional, Costa, Luisa, additional, Giacomelli, Roberto, additional, Scarpa, Raffaele, additional, Cirino, Giuseppe, additional, Bucci, Mariarosaria, additional, McGettrick, Helen M, additional, Grieco, Paolo, additional, Iqbal, Asif Jilani, additional, and Maione, Francesco, additional

Published
2023
Full Text
View/download PDF

8. Balancing Affinity, Selectivity, and Cytotoxicity of Hydrazone-Based G-Quadruplex Ligands for Activation of Interferon β Genes in Cancer Cells

Author

Marzano, Simona, primary, Miglietta, Giulia, additional, Morigi, Rita, additional, Marinello, Jessica, additional, Arleo, Andrea, additional, Procacci, Monica, additional, Locatelli, Alessandra, additional, Leoni, Alberto, additional, Pagano, Bruno, additional, Randazzo, Antonio, additional, Amato, Jussara, additional, and Capranico, Giovanni, additional

Published
2022
Full Text
View/download PDF

10. Synthesis and Characterization of Bis-Triazolyl-Pyridine Derivatives as Noncanonical DNA-Interacting Compounds

Author

Di Porzio, Anna, primary, Galli, Ubaldina, additional, Amato, Jussara, additional, Zizza, Pasquale, additional, Iachettini, Sara, additional, Iaccarino, Nunzia, additional, Marzano, Simona, additional, Santoro, Federica, additional, Brancaccio, Diego, additional, Carotenuto, Alfonso, additional, De Tito, Stefano, additional, Biroccio, Annamaria, additional, Pagano, Bruno, additional, Tron, Gian Cesare, additional, and Randazzo, Antonio, additional

Published
2021
Full Text
View/download PDF

11. Identification of effective anticancer G-quadruplex-targeting chemotypes through the exploration of a high diversity library of natural compounds

Author

Mori, Mattia, primary, Platella, Chiara, additional, Ghirga, Francesca, additional, Zizza, Pasquale, additional, Pompili, Luca, additional, Marzano, Simona, additional, Pagano, Bruno, additional, Quaglio, Deborah, additional, Vergine, Valeria, additional, Cammarone, Silvia, additional, Botta, Bruno, additional, Biroccio, Annamaria, additional, and Montesarchio, Daniela, additional

Published
2021
Full Text
View/download PDF

13. Identification of Effective Anticancer G-Quadruplex-Targeting Chemotypes through the Exploration of a High Diversity Library of Natural Compounds

Author

Platella, Chiara, primary, Ghirga, Francesca, additional, Zizza, Pasquale, additional, Pompili, Luca, additional, Marzano, Simona, additional, Pagano, Bruno, additional, Quaglio, Deborah, additional, Vergine, Valeria, additional, Cammarone, Silvia, additional, Botta, Bruno, additional, Biroccio, Annamaria, additional, Mori, Mattia, additional, and Montesarchio, Daniela, additional

Published
2021
Full Text
View/download PDF

16. Printed Electrochemical Strip for the Detection of miRNA-29a: A Possible Biomarker Related to Alzheimer's Disease

Author

Antonella Miglione, Ada Raucci, Jussara Amato, Simona Marzano, Bruno Pagano, Tiziana Raia, Marco Lucarelli, Andrea Fuso, Stefano Cinti, Miglione, Antonella, Raucci, Ada, Amato, Jussara, Marzano, Simona, Pagano, Bruno, Raia, Tiziana, Lucarelli, Marco, Fuso, Andrea, and Cinti, Stefano

Subjects
Neurodegenerative Disease, Metal Nanoparticles, MicroRNA, Neurodegenerative Diseases, Biomarker, Biosensing Techniques, Analytical Chemistry, Metal Nanoparticle, MicroRNAs, Alzheimer Disease, Humans, Gold, Biomarkers, Human
Abstract

The development of electrochemical strips, as extremely powerful diagnostic tools, has received much attention in the field of sensor analysis and, in particular, the detection of nucleic acids in complex matrixes is a hot topic in the electroanalytical area, especially when directed toward the development of emerging technologies, for the purpose of facilitating personal healthcare. One of the major diseases for which early diagnosis is crucial is represented by Alzheimer's disease (AD). AD is a progressive neurodegenerative disease, and it is the most common cause of dementia worldwide. In this context microRNAs (miRNAs), which are small noncoding RNAs, have recently been highlighted for their promising role as biomarkers for early diagnosis. In particular, miRNA-29 represents a class of miRNAs known to regulate pathogenesis of AD. In this work we developed an electrochemical printed strip for the detection of miRNA-29a at low levels. The architecture was characterized by the presence of gold nanoparticles (AuNPs) and an anti-miRNA-29a probe labeled with a redox mediator. The novel analytical tool has been characterized with microscale thermophoresis and electrochemical methods, and it has been optimized by selection of the most appropriate probe density to detect low target concentration. The present tool was capable to detect miRNA-29a both in standard solution and in serum, respectively, down to 0.15 and 0.2 nM. The platform highlighted good repeatability (calculated as the relative standard deviation) of ca. 10% and satisfactory selectivity in the presence of interfering species. This work has the objective to open a way for the study and possible early diagnosis of a physically and socially devastating disease such as Alzheimer's. The results demonstrate the suitability of this approach in terms of ease of use, time of production, sensitivity, and applicability.

Published
2022

17. Balancing Affinity, Selectivity, and Cytotoxicity of Hydrazone-Based G-Quadruplex Ligands for Activation of Interferon β Genes in Cancer Cells

Author

Simona Marzano, Giulia Miglietta, Rita Morigi, Jessica Marinello, Andrea Arleo, Monica Procacci, Alessandra Locatelli, Alberto Leoni, Bruno Pagano, Antonio Randazzo, Jussara Amato, Giovanni Capranico, Marzano, Simona, Miglietta, Giulia, Morigi, Rita, Marinello, Jessica, Arleo, Andrea, Procacci, Monica, Locatelli, Alessandra, Leoni, Alberto, Pagano, Bruno, Randazzo, Antonio, Amato, Jussara, and Capranico, Giovanni

Subjects
Cytostatic Agent, Hydrazones, Ligand, Antineoplastic Agents, Interferon-beta, Cytostatic Agents, Ligands, Hydrazone, Genomic Instability, Antineoplastic Agent, G-Quadruplexes, Neoplasms, Drug Discovery, G-Quadruplexe, Molecular Medicine, Humans, Human
Abstract

G-quadruplex (G4) ligands are investigated to discover new anticancer drugs with increased cell-killing potency. These ligands can induce genome instability and activate innate immune genes at non-cytotoxic doses, opening the discovery of cytostatic immune-stimulating ligands. However, the interplay of G4 affinity/selectivity with cytotoxicity and immune gene activation is not well-understood. We investigated a series of closely related hydrazone derivatives to define the molecular bases of immune-stimulation activity. Although they are closely related to each other, such derivatives differ in G4 affinity, cytotoxicity, genome instability, and immune gene activation. Our findings show that G4 affinity of ligands is a critical feature for immune gene activation, whereas a high cytotoxic potency interferes with it. The balance of G4 stabilization versus cytotoxicity can determine the level of immune gene activation in cancer cells. Thus, we propose a new rationale based on low cell-killing potency and high immune stimulation to discover effective anticancer G4 ligands.

Published
2022

18. Development of a multi-targeted chemotherapeutic approach based on G-quadruplex stabilisation and carbonic anhydrase inhibition.

Author

Nocentini A, Di Porzio A, Bonardi A, Bazzicalupi C, Petreni A, Biver T, Bua S, Marzano S, Amato J, Pagano B, Iaccarino N, De Tito S, Amente S, Supuran CT, Randazzo A, and Gratteri P

Subjects
Humans, Structure-Activity Relationship, Molecular Structure, Cell Proliferation drug effects, Ligands, HeLa Cells, Antigens, Neoplasm metabolism, Models, Molecular, G-Quadruplexes drug effects, Carbonic Anhydrase Inhibitors pharmacology, Carbonic Anhydrase Inhibitors chemistry, Carbonic Anhydrase Inhibitors chemical synthesis, Antineoplastic Agents pharmacology, Antineoplastic Agents chemistry, Antineoplastic Agents chemical synthesis, Carbonic Anhydrase IX antagonists & inhibitors, Carbonic Anhydrase IX metabolism, Carbonic Anhydrases metabolism, Drug Screening Assays, Antitumor, Dose-Response Relationship, Drug
Abstract

A novel class of compounds designed to hit two anti-tumour targets, G-quadruplex structures and human carbonic anhydrases (hCAs) IX and XII is proposed. The induction/stabilisation of G-quadruplex structures by small molecules has emerged as an anticancer strategy, disrupting telomere maintenance and reducing oncogene expression. hCAs IX and XII are well-established anti-tumour targets, upregulated in many hypoxic tumours and contributing to metastasis. The ligands reported feature a berberine G-quadruplex stabiliser scaffold connected to a moiety inhibiting hCAs IX and XII. In vitro experiments showed that our compounds selectively stabilise G-quadruplex structures and inhibit hCAs IX and XII. The crystal structure of a telomeric G-quadruplex in complex with one of these ligands was obtained, shedding light on the ligand/target interaction mode. The most promising ligands showed significant cytotoxicity against CA IX-positive HeLa cancer cells in hypoxia, and the ability to stabilise G-quadruplexes within tumour cells.

Published
2024
Full Text
View/download PDF

19. Sensitization of melanoma cells to standard chemotherapy: G-quadruplex binders as synergistic agents.

Author

Persico C, Iaccarino N, Romano F, Giustiniano M, Russo C, Laneri S, Di Lorenzo R, Aiello I, Abate S, Izzo L, Merlino F, Brancaccio D, Pagano B, Amato J, Marzano S, D'Aria F, De Tito S, Di Porzio A, and Randazzo A

Abstract

The use of chemotherapeutics has achieved considerable success in cancer therapy; however, their toxicity can severely impact patients' health. In this study, aiming to reduce the doses and potential side effects of traditional chemotherapeutics, we systematically treated A375MM human melanoma cells with seven clinically approved antineoplastic drugs, in combination with three well-characterized G-quadruplex (G4) ligands, using either simultaneous or sequential dosing schedules. Interestingly, the G4 binders synergized with most of the investigated anticancer drugs, with the degree of synergism being strictly dependent on both the treatment schedule and the drug sequence employed. Notably, some of the synergistic combinations showed selective toxicity toward melanoma cells over nontumorigenic human keratinocytes. Furthermore, immunofluorescence experiments highlighted the potential implication of G4 structures in the molecular mechanisms driving the synergistic interaction between some chemotherapeutics and G4 binders. Overall, our systematic study supports the combination of G4-interacting molecules with standard antineoplastic drugs as a promising antitumor strategy., (© The Author(s) 2024. Published by Oxford University Press on behalf of NAR Cancer.)

Published
2024
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results