118 results on '"Marzano, N"'
Search Results
2. GOIM 2107 STUDY PRELIMINARY DATA: MULTICENTER PHASE II STUDY OF SEQUENTIAL ORMONOTHERAPY WITH ANASTROZOL/EXEMESTANE (ARIM-AROM) IN METASTATIC BREAST DISEASE
- Author
-
Formato, R., Iaffaioli, R. V., Tortoriello, A., Del Prete, S., Caraglia, M., Pisano, A., Fanelli, F., Ianniello, G., Quattrin, S., Cigolari, S., Cartenì, G., Pizza, C., Marano, O., Pezzella, G., Pedicini, T., Febbraro, A., Incoronato, P., Manzione, L., Ferrari, E., Marzano, N., Giotta, G., and Colucci, G.
- Published
- 2003
3. HYPOXIC LOCOREGIONAL CHEMOTHERAPY (STOP-FLOW) IN ABDOMINAL AND PELVIC RELAPSES. PHASE I STUDY AND PHASE II PRELIMINARY DATA OF SITILO NATIONAL PROJECT.
- Author
-
Facchini, G, Crovella, F, Tortoriello, A, Carbone, I, Turitto, G, Iaccarino, V, Memoli, B, Lombardi, R, Frattolillo, A, Mallarino, G, Coppola, Morelli G, Ghiani, M, Renda, A, Marzano, N, Memeo, V, Ionta, M T, Romano, G, Massidda, B, Mantovani, G, and Iaffaioli, R V
- Published
- 2000
4. DOCETAXEL + LETROZOLE + PAMIDRONATE + RADIOTHERAPY ± GOSERELIN IN THE TREATMENT BONE METASTASES BY BREAST CANCER. PRELIMINARY DATA OF PHASE II STUDY.
- Author
-
Tortoriello, A, Marzano, N, Facchini, G, Turitto, G, Procaccini, E, Frattolillo, A, Lombardi, R, Cigolari, S, La Provitera, A, Libutti, M, Ciccarelli, P D, Santangelo, M, and Iaffaioli, R V
- Published
- 2000
5. Geochemical features of distinct depositional facies in coastal/deltaic setting of the Padanian plain (Northern Italy): insights on carbon dynamics and selective metal accumulation
- Author
-
Natali, C., Bianchini, G., Vittori Antisari, L., Marzano, N., Salani, GIAN MARCO, and Tessari, U.
- Subjects
Sediment geochemistry ,Ambientale ,coastal/deltaic setting ,Sediment geochemistry, metal accumulation, coastal/deltaic setting ,metal accumulation ,PE10_11 - Published
- 2018
6. Management of Italian patients with advanced non-small-cell lung cancer after second-line treatment: results of the longitudinal phase of the LIFE observational study
- Author
-
De Marinis, Filippo, Ardizzoni, Andrea, Fontanini, Gabriella, Grossi, Francesco, Cappuzzo, Federico, Novello, Silvia, Santo, Antonio, Lorusso, Vito, Cortinovis, Diego, Iurlaro, Monica, Galetta, Domenico, Gridelli, Cesare, Pedrazzoli P, Siena S, Alabiso O, Bilancia D, Cinieri S, Cartenì G, Fasola G, Ferraù F, Milella M, Contu A, Giuffrida D, Illiano A, Ravaioli A, Zaniboni A, Bettini A, Caprioli A, Longo F, Cruciani G, Defraia E, Favaretto A, Amadori D, Clerico M, Di Costanzo F, Gamucci T, Caruso M, Iacobelli S, Pinotti G, Pozzessere D, Maiello E, Marchetti P, Passalacqua R, Pavesi L, Tortora G, Aglietta M, Brandes A, Ciuffreda L, Daniele B, Demichelis C, Romito S, Tamberi S, Barni S, Barbieri F, Giordano M, Bracarda S, Crinò L, Marzano N, Merlano M, Numico G., BIANCO, ROBERTO, De Marinis, Filippo, Ardizzoni, Andrea, Fontanini, Gabriella, Grossi, Francesco, Cappuzzo, Federico, Novello, Silvia, Santo, Antonio, Lorusso, Vito, Cortinovis, Diego, Iurlaro, Monica, Galetta, Domenico, Gridelli, Cesare, Pedrazzoli, P, Siena, S, Alabiso, O, Bilancia, D, Cinieri, S, Cartenì, G, Fasola, G, Ferraù, F, Milella, M, Contu, A, Giuffrida, D, Illiano, A, Ravaioli, A, Zaniboni, A, Bettini, A, Caprioli, A, Longo, F, Cruciani, G, Defraia, E, Favaretto, A, Amadori, D, Clerico, M, Di Costanzo, F, Gamucci, T, Caruso, M, Iacobelli, S, Pinotti, G, Pozzessere, D, Maiello, E, Marchetti, P, Passalacqua, R, Pavesi, L, Tortora, G, Aglietta, M, Bianco, Roberto, Brandes, A, Ciuffreda, L, Daniele, B, Demichelis, C, Romito, S, Tamberi, S, Barni, S, Barbieri, F, Giordano, M, Bracarda, S, Crinò, L, Marzano, N, Merlano, M, and Numico, G.
- Subjects
Oncology ,Male ,Cancer Research ,Lung Neoplasms ,medicine.medical_treatment ,Longitudinal Studie ,medicine.disease_cause ,NSCLC ,Antineoplastic Agent ,Chemotherapy ,EGFR ,Erlotinib ,Third-line ,Cohort Studies ,Carcinoma, Non-Small-Cell Lung ,80 and over ,Anaplastic lymphoma kinase ,Anaplastic Lymphoma Kinase ,Longitudinal Studies ,Non-Small-Cell Lung ,DOCETAXEL ,Aged, 80 and over ,Proto-Oncogene Protein ,Tumor ,CHEMOTHERAPY ,Middle Aged ,OPEN-LABEL ,Receptor Protein-Tyrosine Kinase ,ErbB Receptors ,Italy ,Cohort ,Disease Progression ,Female ,KRAS ,CLINICAL-PRACTICE GUIDELINES ,medicine.drug ,Human ,Pulmonary and Respiratory Medicine ,Adult ,medicine.medical_specialty ,ERLOTINIB ,Antineoplastic Agents ,Proto-Oncogene Proteins p21(ras) ,Erlotinib Hydrochloride ,Internal medicine ,Proto-Oncogene Proteins ,medicine ,Biomarkers, Tumor ,Humans ,Lung cancer ,Aged ,III TRIAL ,business.industry ,Carcinoma ,Quinazoline ,3RD-LINE THERAPY ,Receptor Protein-Tyrosine Kinases ,medicine.disease ,ras Protein ,1ST-LINE TREATMENT ,FOLLOW-UP ,Clinical trial ,Lung Neoplasm ,Mutation ,Quinazolines ,ras Proteins ,Observational study ,Receptor, Epidermal Growth Factor ,Cohort Studie ,business ,Biomarkers - Abstract
Introduction/Background Patients with advanced NSCLC who experience disease progression after second-line therapy might receive further active treatment. LIFE was an Italian cohort multicenter observational study composed of a cross-sectional and a longitudinal phase. Patients and Methods In the longitudinal phase, described here, the primary aim was to determine the proportion of patients receiving third-line therapy among those who received second-line active treatment according to clinical practice. The proportion of patients receiving further treatment lines was also estimated. Results The longitudinal phase was conducted between January and August 2012. Of 464 patients who began second-line therapy outside of clinical trials within the baseline evaluation, 56 (12.1%) were still receiving second-line therapy at the end of the observation period and 17 (3.7%) withdrew during or after second-line therapy. Of the remaining 391 patients, 158 (40.4%) received third-line treatment outside of clinical trials: 93 received a third-line chemotherapy and 65 a targeted agent. The main reason for interrupting third-line treatment was disease progression or death. During the same observation period, 25 of 113 patients who completed a third-line therapy received a fourth line of treatment. From diagnosis of NSCLC to the end of observation, biomarkers were tested in 323 patients (59.7%): epidermal growth factor receptor mutations in 315 (58.2%), Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) mutations in 83 (15.3%) and Anaplastic lymphoma kinase (ALK) translocation in 84 (15.5%). Conclusion In Italian clinical practice, the proportion of patients with advanced NSCLC receiving more than 2 treatment lines of therapy is not negligible.
- Published
- 2014
7. P223 Adaptability and reproducibility of a memory disruption rTMS protocol in the PharmaCog IMI European project
- Author
-
Martin, P., primary, Lanteaume, L., additional, Solana, E., additional, Casse-Perrot, C., additional, Fernández-Cabello, S., additional, Babiloni, C., additional, Marzano, N., additional, Junqué, C., additional, Rossini, P.M., additional, Micallef, J., additional, Truillet, R., additional, Charles, E., additional, Jouve, E., additional, Bordet, R., additional, Valls-Solé, J., additional, Rossi, S., additional, Pascual-Leone, A., additional, Blin, O., additional, Richardson, J., additional, and Bartrés-Faz, D., additional
- Published
- 2017
- Full Text
- View/download PDF
8. Cross-sectional clinical, neuropsychological, neuroimaging, and neurophysiological characterization of mild cognitive impairment patients in WP5 PharmaCog/E-ADNI study
- Author
-
Galluzzi, S., Marizzoni, M., Babiloni, C., Bartres-Faz, D., Blin, O., Bordet, R., Bosch, B., Anna, F., Didic, M., Farotti, L., Forloni, G., Jovicich, J., Marra, C., Marzano, N., Molinuevo, J. L., Nobili, F., Pariente, J., Parnetti, L., Payoux, P., Picco, A., Quaranta, D., Ranjeva, J. P., Roccatagliata, L., Rossini, P. M., Salvadori, N., Schonknecht, P., Andrea Soricelli, Tsolaki, M., Vecchio, F., Visser, P. J., Wiltfang, J., Frisoni, G. B., and Pharmacog, Consortium
- Subjects
Medizin ,ComputingMethodologies_GENERAL - Abstract
Poster Abstract
- Published
- 2014
9. Incidence, characteristics and treatment of fatigue in oncological cancer patients (pts) in italy: a cross-section study
- Author
-
Roila, F., primary, Spina, F., additional, Ripamonti, C., additional, Fumi, G., additional, Antonuzzo, A., additional, Cavanna, L., additional, Gori, S., additional, Mirabile, A., additional, Fabi, A., additional, Marzano, N., additional, Graiff, C., additional, De Sanctis, V., additional, Serpentini, S., additional, Bocci, C., additional, Pino, M.S., additional, Clienti, G., additional, Verusio, C., additional, Lutrino, S.E., additional, Fatigoni, S., additional, and Ballatori, E., additional
- Published
- 2016
- Full Text
- View/download PDF
10. ID 286 – Auditory oddball event-related potentials cortical sources are related to cerebrospinal fluid (CSF)® amyloid (A®) level in amnesic MCI subjects
- Author
-
Cordone, S., primary, Del Percio, C., additional, Marzano, N., additional, Noce, G., additional, Bagnoli, C., additional, Rossini, P.M., additional, Soricelli, A., additional, Famá, F., additional, Bartres Faz, D., additional, Blin, O., additional, Payoux, P., additional, Bordet, R., additional, Müller, B.W., additional, Tsolaki, M., additional, Parnetti, L., additional, Hegerl, U., additional, Hensch, T., additional, Dukart, J., additional, Bertolino, A., additional, Forloni, G., additional, Richardson, J.C., additional, Frisoni, G., additional, and Babiloni, C., additional
- Published
- 2016
- Full Text
- View/download PDF
11. Cortical generation of on-going “Delta” and “Alpha” EEG rhythms in mouse models of Alzheimer’s disease and Alzheimer’s disease patients at prodromic stages
- Author
-
Babiloni, C., primary, Del Percio, C., additional, Marzano, N., additional, Cordone, S., additional, Noce, G., additional, Bagnoli, C., additional, Rossini, P. Maria, additional, Soricelli, A., additional, Nobili, F. Mariano, additional, Faz, D. Bartres, additional, Blin, O., additional, Payoux, P., additional, Bordet, R., additional, Mueller, B., additional, Tsolaki, M., additional, Parnetti, L., additional, Hegerl, U., additional, Hensch, T., additional, Dukart, J., additional, Bertolino, A., additional, Forloni, G., additional, Frasca, A., additional, Richardson, J., additional, Bastlund, J. Frank, additional, Clausen, B., additional, Bentivoglio, M., additional, Fabene, P.F., additional, Bertini, G., additional, Dix, S., additional, Kelley, J., additional, Drinkenburg, W., additional, and Frisoni, G., additional
- Published
- 2016
- Full Text
- View/download PDF
12. ID 284 – Abnormal delta cortical sources of resting state eyes closed EEG rhythms correlate with cerebrospinal fluid (CSF) ® amyloid (A®) level in amnesic MCI subjects
- Author
-
Noce, G., primary, Del Percio, C., additional, Marzano, N., additional, Cordone, S., additional, Bagnoli, C., additional, Rossini, P.M., additional, Soricelli, A., additional, Nobili, F.M., additional, Bartres Faz, D., additional, Blin, O., additional, Payoux, P., additional, Bordet, R., additional, Müller, B.W., additional, Tsolaki, M., additional, Parnetti, L., additional, Hegerl, U., additional, Hensch, T., additional, Dukar, J., additional, Bertolino, A., additional, Forloni, G., additional, Richardson, J.C., additional, Frisoni, G., additional, and Babiloni, C., additional
- Published
- 2016
- Full Text
- View/download PDF
13. Phase II study of sequential hormonal therapy with anastrozole/exemestane in advanced and metastatic breast cancer
- Author
-
IAFFAIOLI RV, FORMATO R, TORTORIELLO A, DEL PRETE S, PAPPAGALLO G, PISANO A, GEBBIA V, FANELLI F, IANNIELLO G, CIGOLARI S, PIZZA C, MARANO O, PEZZELLA G, PEDICINI T, FEBBRARO A, INCORONATO P, MANZIONE L, FERRARI E, MARZANO N, QUATTRIN S, PISCONTI S, NASTI G, GIOTTA G, COLUCCI G, SOUTHERN ITALY ONCOLOGY GROUP, CARAGLIA, Michele, Iaffaioli, Rv, Formato, R, Tortoriello, A, DEL PRETE, S, Caraglia, Michele, Pappagallo, G, Pisano, A, Gebbia, V, Fanelli, F, Ianniello, G, Cigolari, S, Pizza, C, Marano, O, Pezzella, G, Pedicini, T, Febbraro, A, Incoronato, P, Manzione, L, Ferrari, E, Marzano, N, Quattrin, S, Pisconti, S, Nasti, G, Giotta, G, Colucci, G, and SOUTHERN ITALY ONCOLOGY, Group
- Published
- 2005
14. Neurophysiological Assessment of Alzheimer's Disease Individuals by a Single Electroencephalographic Marker
- Author
-
Lizio, R, Del Percio, C, Marzano, N, Soricelli, A, Yener, GG, Başar, E, Mundi, C, De Rosa, S, Triggiani, AI, Ferri, R, Arnaldi, D, Nobili, FM, Cordone, S, Lopez, S, Carducci, F, Santi, G, Gesualdo, L, ROSSINI, PAOLO MARIA, Cavedo, E, Mauri, M, Frisoni, GB, Babiloni, C, Lizio, R, Del Percio, C, Marzano, N, Soricelli, A, Yener, GG, Başar, E, Mundi, C, De Rosa, S, Triggiani, AI, Ferri, R, Arnaldi, D, Nobili, FM, Cordone, S, Lopez, S, Carducci, F, Santi, G, Gesualdo, L, ROSSINI, PAOLO MARIA, Cavedo, E, Mauri, M, Frisoni, GB, and Babiloni, C
- Published
- 2015
15. Occipital sources of resting-state alpha rhythms are related to local gray matter density in subjects with amnesic mild cognitive impairment and Alzheimer's disease
- Author
-
Babiloni, C, Del Percio, C, Boccardi, M, Lizio, R, Lopez, S, Carducci, F, Marzano, N, Soricelli, A, Ferri, R, Triggiani, Ai, Prestia, A, Salinari, S, Rasser, Pe, Basar, E, Famà, F, Nobili, F, Yener, G, Emek Savaş, Dd, Gesualdo, L, Mundi, C, Thompson, Pm, Rossini, Paolo Maria, Frisoni, Gb, Rossini, Paolo Maria (ORCID:0000-0003-2665-534X), Babiloni, C, Del Percio, C, Boccardi, M, Lizio, R, Lopez, S, Carducci, F, Marzano, N, Soricelli, A, Ferri, R, Triggiani, Ai, Prestia, A, Salinari, S, Rasser, Pe, Basar, E, Famà, F, Nobili, F, Yener, G, Emek Savaş, Dd, Gesualdo, L, Mundi, C, Thompson, Pm, Rossini, Paolo Maria, Frisoni, Gb, and Rossini, Paolo Maria (ORCID:0000-0003-2665-534X)
- Abstract
Occipital sources of resting-state electroencephalographic (EEG) alpha rhythms are abnormal, at the group level, in patients with amnesic mild cognitive impairment (MCI) and Alzheimer's disease (AD). Here, we evaluated the hypothesis that amplitude of these occipital sources is related to neurodegeneration in occipital lobe as measured by magnetic resonance imaging. Resting-state eyes-closed EEG rhythms were recorded in 45 healthy elderly (Nold), 100 MCI, and 90 AD subjects. Neurodegeneration of occipital lobe was indexed by weighted averages of gray matter density, estimated from structural MRIs. EEG rhythms of interest were alpha 1 (8-10.5 Hz) and alpha 2 (10.5-13 Hz). EEG cortical sources were estimated by low-resolution brain electromagnetic tomography. Results showed a positive correlation between occipital gray matter density and amplitude of occipital alpha 1 sources in Nold, MCI, and AD subjects as a whole group (r = 0.3, p = 0.000004, N = 235). Furthermore, there was a positive correlation between the amplitude of occipital alpha 1 sources and cognitive status as revealed by Mini Mental State Examination score across all subjects (r = 0.38, p = 0.000001, N = 235). Finally, amplitude of occipital alpha 1 sources allowed a moderate classification of individual Nold and AD subjects (sensitivity: 87.8%; specificity: 66.7%; area under the receiver operating characteristic curve: 0.81). These results suggest that the amplitude of occipital sources of resting-state alpha rhythms is related to AD neurodegeneration in occipital lobe along pathologic aging.
- Published
- 2015
16. Poor desynchronisation of resting-state eyes-open cortical alpha rhythms in obese subjects without eating disorders
- Author
-
Del Percio, C, Triggiani, Ai, Marzano, N, Valenzano, A, De Rosas, M, Petito, A, Bellomo, A, Lecce, B, Mundi, C, Infarinato, F, Soricelli, Andrea, Limatola, C, Cibelli, G, and Babiloni, C.
- Published
- 2013
17. Functional Cortico-Muscular Coupling During Upright Standing In Athletes And Non-Athletes: A Coherence EEG-EMG Study
- Author
-
Vecchio, F, DEL PERCIO, Claudio, Marzano, N, Fiore, A, Toran, G, Aschieri, P, Gallamini, M, Cabras, J, Babiloni, Claudio, and Eusebi, Fabrizio
- Published
- 2008
18. Golf putt outcomes are predicted by sensorimotor cerebral EEG rhythms
- Author
-
Babiloni, Claudio, DEL PERCIO, Claudio, Iacoboni, Marco, Infarinato, F, Lizio, Roberta, Marzano, N, Crespi, G, Dassù, F, Pirritano, M, Gallamini, M, and Eusebi, Fabrizio
- Subjects
Adult ,Male ,Adolescent ,Special Section Related Papers ,Athletic Performance ,Motor Activity ,Alpha Rhythm ,Golf ,Humans ,Computer Simulation ,Female ,Beta Rhythm ,Postural Balance ,Psychomotor Performance - Abstract
It is not known whether frontal cerebral rhythms of the two hemispheres are implicated in fine motor control and balance. To address this issue, electroencephalographic (EEG) and stabilometric recordings were simultaneously performed in 12 right-handed expert golfers. The subjects were asked to stand upright on a stabilometric force platform placed at a golf green simulator while playing about 100 golf putts. Balance during the putts was indexed by body sway area. Cortical activity was indexed by the power reduction in spatially enhanced alpha (8-12 Hz) and beta (13-30 Hz) rhythms during movement, referred to as the pre-movement period. It was found that the body sway area displayed similar values in the successful and unsuccessful putts. In contrast, the high-frequency alpha power (about 10-12 Hz) was smaller in amplitude in the successful than in the unsuccessful putts over the frontal midline and the arm and hand region of the right primary sensorimotor area; the stronger the reduction of the alpha power, the smaller the error of the unsuccessful putts (i.e. distance from the hole). These results indicate that high-frequency alpha rhythms over associative, premotor and non-dominant primary sensorimotor areas subserve motor control and are predictive of the golfer's performance.
- Published
- 2007
19. Cortical sources of resting state EEG rhythms are sensitive to the progression of early stage Alzheimer's disease
- Author
-
Laudio, Lizio, R, Del Percio, C, Marzano, N, Soricelli, A, Salvatore, E, Ferri, R, Cosentino, Fii, Tedeschi, G, Montella, P, Marino, S, De Salvo, S, Rodriguez, G, Nobili, F, Vernieri, F, Ursini, F, Mundi, C, Richardson, Jc, Frisoni, Giovanni, Rossini, Paolo Maria, Rossini, Paolo Maria (ORCID:0000-0003-2665-534X), Laudio, Lizio, R, Del Percio, C, Marzano, N, Soricelli, A, Salvatore, E, Ferri, R, Cosentino, Fii, Tedeschi, G, Montella, P, Marino, S, De Salvo, S, Rodriguez, G, Nobili, F, Vernieri, F, Ursini, F, Mundi, C, Richardson, Jc, Frisoni, Giovanni, Rossini, Paolo Maria, and Rossini, Paolo Maria (ORCID:0000-0003-2665-534X)
- Abstract
Cortical sources of resting state electroencephalographic (EEG) rhythms are abnormal in subjects with Alzheimer's disease (AD). Here we tested the hypothesis that these sources are also sensitive to the progression of early stage AD over the course of one year. The resting state eyes-closed EEG data were recorded in 88 mild AD patients at baseline (Mini Mental State Evaluation, MMSE I = 21.7 ± 0.2 standard error, SE) and at approximately one-year follow up (13.3 months ± 0.5 SE; MMSE II = 20 ± 0.4 SE). All patients received standard therapy with acetylcholinesterase inhibitors. EEG recordings were also performed in 35 normal elderly (Nold) subjects as controls. EEG rhythms of interest were delta (2-4 Hz), theta (4-8 Hz), alpha 1 (8-10.5 Hz), alpha 2 (10.5-13 Hz), beta 1 (13-20 Hz), beta 2 (20-30 Hz), and gamma (30-40 Hz). Cortical EEG sources were estimated by low-resolution brain electromagnetic tomography (LORETA). Compared to the Nold subjects, the mild AD patients were characterized by a power increase of widespread delta sources and by a power decrease of posterior alpha sources. In the mild AD patients, the follow-up EEG recordings showed increased power of widespread delta sources as well as decreased power of widespread alpha and posterior beta 1 sources. These results suggest that the resting state EEG sources were sensitive, at least at group level, to the cognitive decline occurring in the mild AD group over a one-year period, and might represent cost-effective and non-invasive markers with which to enrich cohorts of AD patients that decline faster for clinical studies.
- Published
- 2013
20. Resting state cortical electroencephalographic rhythms in covert hepatic encephalopathy and Alzheimer's disease
- Author
-
Babiloni, C, Vecchio, F, Del Percio, C, Montagnese, S, Schiff, S, Lizio, R, Ghini, G, Serviddio, G, Marzano, N, Sorricelli, A, Frisoni, Gb, Rossini, Paolo Maria, Amodio, P., Rossini, Paolo Maria (ORCID:0000-0003-2665-534X), Babiloni, C, Vecchio, F, Del Percio, C, Montagnese, S, Schiff, S, Lizio, R, Ghini, G, Serviddio, G, Marzano, N, Sorricelli, A, Frisoni, Gb, Rossini, Paolo Maria, Amodio, P., and Rossini, Paolo Maria (ORCID:0000-0003-2665-534X)
- Abstract
Patients suffering from prodromal (i.e., amnestic mild cognitive impairment, aMCI) and overt Alzheimer's disease (AD) show abnormal cortical sources of resting state electroencephalographic (EEG) rhythms. Here we tested the hypothesis that these sources show extensive abnormalities in liver cirrhosis (LC) patients with a cognitive impairment due to covert and diffuse hepatic encephalopathy (CHE). EEG activity was recorded in 64 LC (including 21 CHE), 21 aMCI, 21 AD, and 21 cognitively intact (Nold) subjects. EEG rhythms of interest were delta (2-4 Hz), theta (4-8 Hz), alpha 1 (8-10.5 Hz), alpha 2 (10.5-13 Hz), beta 1 (13-20 Hz), and beta 2 (20-30 Hz). EEG cortical sources were estimated by LORETA. Widespread sources of theta (all but frontal), alpha 1 (all but occipital), and alpha 2 (parietal, temporal) rhythms were higher in amplitude in all LC patients than in the Nold subjects. In these LC patients, the activity of central, parietal, and temporal theta sources correlated negatively, and parietal and temporal alpha 2 sources correlated positively with an index of global cognitive status. Finally, widespread theta (all but frontal) and alpha 1 (all but occipital) sources showed higher activity in the sub-group of LC patients with CHE than in the patients with aMCI or AD. These results unveiled the larger spatial-frequency abnormalities of the resting state EEG sources in the CHE compared to the AD condition.
- Published
- 2013
21. 65. Cortical sources of resting state EEG rhythms reflect disease progression over 1year in mild cognitive impairment and Alzheimer’s disease patients
- Author
-
Lizio, R., primary, Babiloni, C., additional, Percio, C. Del, additional, Marzano, N., additional, Soricelli, A., additional, Salvatore, E., additional, Ferri, R., additional, Cosentino, F., additional, Tedeschi, G., additional, Montella, P., additional, Marino, S., additional, Rodriguez, G., additional, Nobili, F., additional, Vernieri, F., additional, Ursini, F., additional, Mundi, C., additional, Frisoni, G.B., additional, and Rossini, P.M., additional
- Published
- 2013
- Full Text
- View/download PDF
22. 64. Resting state cortical electroencephalographic rhythms are related to cerebral hypometabolism in subjects with Alzheimer’s Disease
- Author
-
Lizio, R., primary, Salvatore, E., additional, Caroli, A., additional, Marzano, N., additional, Percio, C. Del, additional, Tedeschi, G., additional, Montella, P., additional, Antonio, G., additional, Fabrizio, E., additional, Frisoni, G.B., additional, Soricelli, A., additional, Babiloni, C., additional, and Rossini, P.M., additional
- Published
- 2013
- Full Text
- View/download PDF
23. Brains 'in concert': frontal oscillatory alpha rhythms and empathy in professional musicians
- Author
-
Babiloni, C, Buffo, P, Vecchio, F, Marzano, N, Del Percio, C, Spada, Daniele, Rossi, Serena, Bruni, I, Rossini, Paolo Maria, Perani, D., Rossini, Paolo Maria (ORCID:0000-0003-2665-534X), Babiloni, C, Buffo, P, Vecchio, F, Marzano, N, Del Percio, C, Spada, Daniele, Rossi, Serena, Bruni, I, Rossini, Paolo Maria, Perani, D., and Rossini, Paolo Maria (ORCID:0000-0003-2665-534X)
- Abstract
Playing music in ensemble represents a unique human condition/performance where musicians should rely on empathic relationships. Recent theories attribute to frontal Brodmann areas (BAs) 44/45 and 10/11 a neural basis for "emotional" and "cognitive" empathy. We hypothesized that activity of these structures reflects empathy trait in professional musicians playing in ensemble. Simultaneous electroencephalographic (EEG) alpha rhythms (8-12 Hz) were recorded in three saxophone quartets during music performance in ensemble (EXECUTION), video observation of their own performance (OBSERVATION), a control task (CONTROL), and resting state (RESTING). EEG source estimation was performed. Results showed that the higher the empathy quotient test score, the higher the alpha desynchronization in right BA 44/45 during the OBSERVATION referenced to RESTING condition. Empathy trait score and alpha desynchronization were not correlated in other control areas or in EXECUTION/CONTROL conditions. These results suggest that alpha rhythms in BA 44/45 reflect "emotional" empathy in musicians observing own performance.
- Published
- 2012
24. Resting state cortical rhythms in mild cognitive impairment and Alzheimer's disease: electroencephalographic evidence
- Author
-
Babiloni, C, Vecchio, Fabio Maria, Lizio, R, Ferri, R, Rodriguez, G, Marzano, N, Frisoni, Gb, Rossini, Paolo Maria, Vecchio, Fabio Maria (ORCID:0000-0002-9197-2264), Rossini, Paolo Maria (ORCID:0000-0003-2665-534X), Babiloni, C, Vecchio, Fabio Maria, Lizio, R, Ferri, R, Rodriguez, G, Marzano, N, Frisoni, Gb, Rossini, Paolo Maria, Vecchio, Fabio Maria (ORCID:0000-0002-9197-2264), and Rossini, Paolo Maria (ORCID:0000-0003-2665-534X)
- Abstract
Physiological brain aging is characterized by a combination of synaptic pruning, loss of cortico-cortical connections and neuronal apoptosis that provoke age-dependent decline of cognitive functions. Neural/synaptic redundancy and plastic remodeling of brain networking, also secondary to mental and physical training, promotes maintenance of brain activity in healthy elderly for everyday life and fully productive affective and intellectual capabilities. Unfortunately, in pathological situations, aging triggers neurodegenerative processes that impact on cognition, like Alzheimer's disease (AD). Oscillatory electromagnetic brain activity is a hallmark of neuronal network function in various brain regions. Modern neurophysiological techniques including digital electroencephalography (EEG) allow non-invasive analysis of cortico-cortical connectivity and neuronal synchronization of firing, and coherence of brain rhythmic oscillations at various frequencies. The present review of field EEG literature suggests that discrimination between physiological and pathological brain aging clearly emerges at the group level, with some promising result on the informative value of EEG markers at the individual level. Integrated approaches utilizing neurophysiological techniques together with biological markers and structural and functional imaging are promising for large-scale, low-cost, widely available on the territory and non-invasive screening of at-risk populations.
- Published
- 2011
25. Simultaneous recording of electroencephalographic data in musicians playing in ensemble
- Author
-
Babiloni, C, Vecchio, Fabio Maria, Infarinato, F, Buffo, P, Marzano, N, Spada, Daniele, Rossi, Sabrina, Bruni, I, Rossini, Paolo Maria, Perani, D., Vecchio, Fabio Maria (ORCID:0000-0002-9197-2264), Rossini, Paolo Maria (ORCID:0000-0003-2665-534X), Babiloni, C, Vecchio, Fabio Maria, Infarinato, F, Buffo, P, Marzano, N, Spada, Daniele, Rossi, Sabrina, Bruni, I, Rossini, Paolo Maria, Perani, D., Vecchio, Fabio Maria (ORCID:0000-0002-9197-2264), and Rossini, Paolo Maria (ORCID:0000-0003-2665-534X)
- Abstract
Here we describe a methodological approach for the simultaneous electroencephalographic (EEG) recording in musicians playing in ensemble. Four professional saxophonists wore pre-wired EEG caps (30 electrodes placed according to an augmented 10-20 system; cephalic reference and ground). Each cap was connected to a single multi-channel amplifier box [Brain Explorer (BE), EB-Neuro(©)]. The four boxes converged to a single workstation equipped with a software (GALILEO NT, EB-Neuro(©)) allowing the simultaneous recording of sounds, digital trigger, and EEG-electrooculographic (EOG)-electromyographic (EMG) data, and providing a separate output file for each individual. Noteworthy, the subjects were electrically decoupled to satisfy international safety guidelines. The quality of the EEG data was confirmed by the rate of artifact-free EEG epochs (about 80%) and by EEG spectral features. During the resting state, dominant EEG power density values were observed at alpha band (8-12Hz) in posterior cortex. The quality of EMG can be used to identify "on" and "off" states of the musicians' motor performance, thus potentially allowing the investigation of the relationships between EEG dynamics and different characteristics of the specific performance. During the music performance, alpha power density values decreased in amplitude in several cortical regions, whereas power density values enhanced within narrow high-frequency bands. In conclusion, the present methodological approach appeared to be suitable for simultaneous EEG recordings in musicians playing in ensemble.
- Published
- 2011
26. Intra-hemispheric functional coupling of alpha rhythms is related to golfer's performance: a coherence EEG study
- Author
-
Babiloni, Infarinato, F, Marzano, N, Iacoboni, M, Dassù, Soricelli, A, Rossini, Paolo Maria, Limatola, C, Del Percio, Claudio, Rossini, Paolo Maria (ORCID:0000-0003-2665-534X), Babiloni, Infarinato, F, Marzano, N, Iacoboni, M, Dassù, Soricelli, A, Rossini, Paolo Maria, Limatola, C, Del Percio, Claudio, and Rossini, Paolo Maria (ORCID:0000-0003-2665-534X)
- Abstract
It has been shown that frontocentral electroencephalographic (EEG) alpha rhythms (about 10-12 Hz) were higher in amplitude in expert golfers in successful than unsuccessful putts, possibly reflecting the idea that amplitude regulation of frontocentral alpha rhythms is a physiological mechanism implied in motor control and golfer's performance (Babiloni et al., 2008). Here, we tested the ancillary hypothesis that golfer's performance is also associated to an improved coordination of cortical activity, as reflected by functional coupling of alpha rhythms across cortical regions. To this aim, between-electrodes spectral coherence was computed from spatially enhanced EEG data of the mentioned study (i.e. right handed 12 expert golfers; augmented 10-20 system; surface Laplacian estimation). Low- (about 8-10 Hz) and high-frequency (about 10-12 Hz) alpha sub-bands were considered with reference to individual alpha frequency peak. Statistical results showed that intra-hemispheric low-frequency alpha coherence in bilateral parietal-frontal (P3-F3 and P4-F4 electrodes) and parietal-central (P3-C3 and P4-C4 electrodes) was higher in amplitude in successful than unsuccessful putts (p<0.004). The same was true for intra-hemispheric high-frequency alpha coherence in bilateral parietal-frontal regions (p<0.004). These findings suggest that intra-hemispheric functional coupling of cortical alpha rhythms between "visuo-spatial" parietal area and other cortical areas is implicated in fine motor control of golfer's performance.
- Published
- 2011
27. Reactivity of alpha rhythms to eyes opening is lower in athletes than non-athletes: a high-resolution EEG study
- Author
-
Del Percio, C, Infarinato, F, Marzano, N, Iacoboni, M, Aschieri, P, Lizio, R, Soricelli, A, Limatola, C, Rossini, Paolo Maria, Babiloni, C., Rossini, Paolo Maria (ORCID:0000-0003-2665-534X), Del Percio, C, Infarinato, F, Marzano, N, Iacoboni, M, Aschieri, P, Lizio, R, Soricelli, A, Limatola, C, Rossini, Paolo Maria, Babiloni, C., and Rossini, Paolo Maria (ORCID:0000-0003-2665-534X)
- Abstract
In the present study, we tested the hypothesis that compared with non-athletes, elite athletes are characterized by a reduction of reactivity of electroencephalographic (EEG) alpha rhythms (about 8-12 Hz) to eyes opening in the condition of resting state, as a possible index of spatially selective cortical activation (i.e. "neural efficiency"). EEG data (56 channels; Eb-Neuro©) were recorded in 18 elite karate athletes and 28 non-athletes during resting state eyes-closed and eyes-open conditions. The EEG data were spatially enhanced by surface Laplacian estimation. Cortical activity was indexed by task-related power decrease (TRPD), namely the alpha power during the eyes-open referenced to the eyes-closed resting condition. Low-frequency alpha TRPD (about 8-10 Hz) was lower in the elite karate athletes than in the non-athletes in frontal (p<0.00002), central (p<0.008) and right occipital (p<0.02) areas. Similarly, high-frequency alpha TRPD (about 10-12 Hz) was lower in the elite karate athletes than in the non-athletes in frontal (p<0.00009) and central (p<0.01) areas. These results suggest that athletes' brain is characterized by reduced cortical reactivity to eyes opening in the condition of resting state, in line with the "neural efficiency" hypothesis. The present study motivates future research evaluating the extent to which this general functional brain feature is related to heritable trait or intensive visuo-motor training of elite athletes.
- Published
- 2011
28. S10 - Incidence, characteristics and treatment of fatigue in oncological cancer patients (pts) in italy: a cross-section study
- Author
-
Roila, F., Spina, F., Ripamonti, C., Fumi, G., Antonuzzo, A., Cavanna, L., Gori, S., Mirabile, A., Fabi, A., Marzano, N., Graiff, C., De Sanctis, V., Serpentini, S., Bocci, C., Pino, M.S., Clienti, G., Verusio, C., Lutrino, S.E., Fatigoni, S., and Ballatori, E.
- Published
- 2016
- Full Text
- View/download PDF
29. Effects of vinorelbine on quality of life and survival of elderly patients with advanced non-small-cell lung cancer
- Author
-
Gridelli, C, Perrone, F, Gallo, C, Rossi, A, Scognamiglio, F, Monfardini, S, Ianniello, Gp, Tinessa, V, Caprio, Mg, Santoro, A, Maiorino, L, Santoro, M, Brancaccio, L, Crispino, C, Cigolari, S, DI LANNO, M, Angelini, V, Manzione, L, Bilancia, D, Dinota, A, Failla, G, Aiello, Ra, Tralongo, P, Figoli, F, Zuccarino, L, Pedicini, T, Febbraro, A, Zollo, C, Frontini, L, Zonato, S, Azzarello, G, Vinante, O, Castiglione, F, Porcile, G, Bearz, A, Sorio, R, Tonato, M, Darwish, S, Veltri, E, D'Aprile, M, Curcio, C, Vasta, M, Clerici, M, Luporini, G, Farris, A, Alicicco, Mg, Bretti, S, Bumma, C, Ionta, Mt, Massidda, B, Adamo, Vincenzo, Altavilla, Giuseppe, Stefani, M, Michetti, G, Iaffaioli, Rv, Marzano, N, Favaretto, A, Murtas, S, Nascimbene, C, Nistico, C, Robbiati, Sf, Strada, Mr, Belli, M, Loizzi, M, Bandera, M, Bochicchio, Am, Piazza, E, Foladore, S, Giura, R, Gualtieri, G, Barni, S, Cariello, A, Mattioli, R, Pazzola, A, Gioga, G, Puxeddu, G, Bartolucci, R, Graiff, C, DEL CONTE, G, Farriniello, Ga, Mauri, F, Corradini, Gm, Capuano, Ma, Carrozza, F, and Gianni, W.
- Published
- 1999
30. Functional coupling of parietal alpha rhythms is enhanced in athletes before visuomotor performance: a coherence electroencephalographic study
- Author
-
Del Percio, C., primary, Iacoboni, M., additional, Lizio, R., additional, Marzano, N., additional, Infarinato, F., additional, Vecchio, F., additional, Bertollo, M., additional, Robazza, C., additional, Comani, S., additional, Limatola, C., additional, and Babiloni, C., additional
- Published
- 2011
- Full Text
- View/download PDF
31. Factors influencing the switch from Tamoxifen (TAM) to Aromatase Inhibitors (AIs) as adjuvant therapy in early breast cancer (EBC) patients (pts). Results from the NORA study
- Author
-
Pronzato, P., primary, Cazzaniga, M. E., additional, Mustacchi, G., additional, De Matteis, A., additional, Di Costanzo, F., additional, Verusio, C., additional, Marzano, N., additional, Rulli, E., additional, and Floriani, I., additional
- Published
- 2006
- Full Text
- View/download PDF
32. Induction Pemetrexed and Cisplatin Followed by Maintenance Pemetrexed Versus Carboplatin Plus Paclitaxel Plus Bevacizumab Followed by Maintenance Bevacizumab: A Quality of Life-Oriented Randomized Phase III Study in Patients With Advanced Non-Squamous Non-Small-Cell Lung Cancer (ERACLE)
- Author
-
Galetta D, Pisconti S, Cinieri S, Pappagallo GL, Gebbia V, Borsellino N, Maiello E, Rinaldi A, Montrone M, Rizzo P, Marzano N, Sasso N, Febbraro A, and Colucci G
- Published
- 2011
- Full Text
- View/download PDF
33. Phase II study of sequential hormonal therapy with anastrozole/exemestane in advanced and metastatic breast cancer.
- Author
-
Iaffaioli, R. V., Formato, R., Tortoriello, A., del Prete, S., Caraglia, M., Pappagallo, G., Pisano, A., Fanelli, F., Ianniello, G., Cigolari, S., Pizza, C., Marano, O., Pezzella, G., Pedicini, T., Febbraro, A., Incoronato, P., Manzione, L., Ferrari, E., Marzano, N., and Quattrin, S.
- Subjects
BREAST cancer ,HORMONE therapy ,CANCER patients ,MEDICAL care ,CYTOCHROME P-450 ,MEDICAL research - Abstract
Hormonal therapy is the preferred systemic treatment for recurrent or metastatic, post-menopausal hormone-receptor-positive breast cancer. Previous studies have shown that there is no cross-resistance between exemestane and reversible aromatase inhibitors. Exposure to hormonal therapy does not hamper later response to chemotherapy. Patients with locally advanced or metastatic, hormonal receptor positive or unknown, breast cancer were treated with oral anastrozole, until disease progression, followed by oral exemestane until new evidence of disease progression. The primary end point of the study was clinical benefit, defined as the sum of complete responses (CR), partial responses (PR) and > 24 weeks stable disease (SD). In all, 100 patients were enrolled in the study. Anastrozole produced eight CR and 19 PR for an overall response rate of 27% (95% CI: 18.6-36.8%). An additional 46 patients had long-term (> 24 weeks) SD for an overall clinical benefit of 73% (95% CI: 63.2-81.4). Median time to progression (TTP) was 11 months (95% CI: 10-12). A total of 50 patients were evaluated for the second-line treatment: exemestane produced one CR and three PR; 25 patients had SD which lasted > or = 6 months in 18 patients. Median TTP was 5 months. Toxicity of treatment was low. Our study confirms that treatment with sequential hormonal agents can extend the period of time during which endocrine therapy can be used, thereby deferring the decision to use chemotherapy. [ABSTRACT FROM AUTHOR]
- Published
- 2005
- Full Text
- View/download PDF
34. Nimesulide Beta Cyclodextrin (Nimesulide-Betadex) Versus Nimesulide in the Treatment of Pain After Arthroscopic Surgery
- Author
-
Vizzardi, M., Visconti, C. S., Pedrotti, L., Marzano, N., Berruto, M., and Scotti, A.
- Published
- 1998
- Full Text
- View/download PDF
35. Phase I-II study of gemcitabine and carboplatin in stage IIIB-IV non- small-cell lung cancer
- Author
-
Iaffaioli, R. V., Tortoriello, A., GAETANO FACCHINI, Caponigro, F., Gentile, M., Marzano, N., Gravina, A., Dimitri, P., Costagliola, G., Ferraro, A., Ferrante, G., Marino, V., and Illiano, A.
36. Cross-sectional clinical, neuropsychological, neuroimaging, and neurophysiological characterization of mild cognitive impairment patients in WP5 PharmaCog/E-ADNI study
- Author
-
Galluzzi, S., Marizzoni, M., Babiloni, C., Bartres-Faz, D., Blin, O., Bordet, R., Bosch, B., Anna, F., Didic, M., Farotti, L., Forloni, G., Jovicich, J., Marra, C., Marzano, N., Molinuevo, Jl, Nobili, F., Pariente, J., Parnetti, L., Payoux, P., Picco, A., Quaranta, D., Ranjeva, Jp, Roccatagliata, L., Rossini, Pm, Salvadori, N., Schonknecht, P., Soricelli, A., Tsolaki, M., Vecchio Fabrizio, Visser, Pj, Wiltfang, J., and Frisoni, Gb
37. Effects of tiredness on visuo-spatial attention processes in élite karate athletes and non-athletes
- Author
-
Del Percio, C., Babiloni, C., Francesco Infarinato, Marzano, N., Iacoboni, M., Lizio, R., Aschieri, P., Cè, E., Rampichini, S., Fanò, G., Veicsteinas, A., and Eusebi, F.
- Subjects
Male ,Analysis of Variance ,Young Adult ,Acoustic Stimulation ,Space Perception ,Reaction Time ,Humans ,Attention ,Female ,Neuropsychological Tests ,Fatigue ,Martial Arts ,Sports - Abstract
"Attentional" adaptations are fundamental effects for sport performance. We tested the hypothesis that tiredness and muscular fatigue poorly affect visuo-spatial attentional processes in elite karate athletes. To this aim, 14 elite karate athletes and 11 non-athletes were involved in an isometric contraction exercise protocol up to muscular fatigue. Blood lactate and attention measurements were taken. Posner's test probed "endogenous" (i.e., internally planned allocation of spatial attention) and "reflexive" (i.e., brisk variation of endogenous spatial attention due to unexpected external stimuli) attention. Lactate and attentional measurements were performed before (Block 1, B1) and after the fatiguing exercise (B2) and at the end of a recovery period (B3). Compared to the non-athletes, the athletes showed a better performance in the fatigue protocol, confirmed by the higher absolute lactate values in B2. The correct responses in the "valid trials" probing "endogenous" attention were 92.4% (B1), 93.9% (B2), and 95.8% (B3) in the non-athletes, and 98.5%, 96.4%, 95.5% in the elite karate athletes. The correct responses in the "invalid trials" probing "reflexive" attention were 95.4%, 89.7%, 93.2% in the non-athletes, and 96.4%, 97.3%, 98.5% in the elite karate athletes. The percentage of correct responses in the "invalid" trials significantly decreased from B1 to B2 in the non-athletes but not in the elite karate athletes. In conclusion, tiredness and muscular fatigue do not affect "reflexive" attentional processes of elite karate athletes, which is crucial to contrast attacks coming from an unexpected spatial region.
38. Italian Network For Autosomal Dominant Alzheimer's Disease and Frontotemporal Lobar Degeneration (ItalianDIAfN): definition of protocols for data collection and genetic counselling
- Author
-
Bocchetta, M., Pievani, M., Babiloni, C., Bruni, Ac, Scarpini, E., Sorbi, S., Tagliavini, F., Padovani, A., Benussi, L., Bernardi, L., Binetti, G., Borroni, B., Di Fede, G., Di Maria, E., Fostinelli, S., Galimberti, D., Gennarelli, M., Ghidoni, R., Marzano, N., Mega, A., Nacmias, B., Piaceri, I., Porteri, C., Rossi, G., Suardi, S., Vecchio Fabrizio, and Frisoni, Gb
39. Hand-Mirror (HM) Cells in Acute Lymphoblastic Leukaemia (A.L.L.)
- Author
-
Ricco, R., primary, Liso, V., additional, Specchia, G., additional, Pavone, V., additional, Marzano, N., additional, Lettini, T., additional, Pesce Delfino, V., additional, and Pennella, A., additional
- Published
- 1989
- Full Text
- View/download PDF
40. Abdominal and pelvic stop-flow (hypoxic, chemotherapeutic loco-regional treatment): Preliminary report of a phase I early phase II study
- Author
-
G. Facchini, B. Massida, A. Tortoriello, M. Santangelo, F. Crovella, I. Carbone, G. Romano, E. D. Salvo, A. Novi, DODARO, CONCETTA ANNA, C. M. Camaggi, E. Strocchi, M. T. Ionta, V. Iaccarino, G. Mallarini, M. Ghiani, A. Bianchi, N. Marzano, V. Memeo, B. Memoli, G. C. Morelli, G. Mantovani, R. V. Iaffaioli, RENDA, ANDREA, Facchini, G, Massida, B, Tortoriello, A, Santangelo, Michele, Crovella, F, Carbone, I, Romano, G, Renda, A, DI SALVO, Enrico, Novi, A, Dodaro, CONCETTA ANNA, Camaggi, Cm, Strocchi, E, Ionta, Mt, Iaccarino, V, Mallarini, G, Ghiani, M, Bianchi, A, Marzano, N, Memeo, V, Memoli, B, Morelli, Gc, Mantovani, G, Iaffaioli, Rv, Facchini, G., Massida, B., Tortoriello, A., Santangelo, M., Crovella, F., Carbone, I., Romano, G., Renda, Andrea, Salvo, E. D., Novi, A., Camaggi, C. M., Strocchi, E., Ionta, M. T., Iaccarino, V., Mallarini, G., Ghiani, M., Bianchi, A., Marzano, N., Memeo, V., Memoli, B., Morelli, G. C., Mantovani, G., and Iaffaioli, R. V.
- Published
- 1998
41. Cortical sources of resting state electroencephalographic alpha rhythms deteriorate across time in subjects with amnesic mild cognitive impairment
- Author
-
Flavio Nobili, Francesco Infarinato, Cinzia Bonforte, Claudio Babiloni, Claudio Del Percio, Andrea Soricelli, Raffaele Ferri, Patrizia Montella, Francesco Famà, Ciro Mundi, Annalisa Baglieri, Gioacchino Tedeschi, Nicola Marzano, Elena Salvatore, Fabrizio Vernieri, Roberta Lizio, Francesca Ursini, Paolo Maria Rossini, Giovanni B. Frisoni, Guido Rodriguez, Babiloni, C, Del Percio, C, Lizio, R, Marzano, N, Francesco, Infarinato, Soricelli, A, Salvatore, Elena, Ferri, R, Bonforte, C, Tedeschi, G, Montella, P, Baglieri, A, Rodriguez, G, Famà, F, Nobili, F, Vernieri, F, Ursini, F, Mundi, C, Frisoni, Gb, Rossini, P. M., DEL PERCIO, C, Infarinato, F, Salvatore, E, and Tedeschi, Gioacchino
- Subjects
Male ,Mild Cognitive Impairment ,Aging ,medicine.medical_specialty ,Time Factors ,low resolution brain electromagnetic tomography (loreta) ,Rest ,Alpha (ethology) ,Audiology ,Electroencephalography ,050105 experimental psychology ,03 medical and health sciences ,0302 clinical medicine ,Rhythm ,disease tracking ,Disease tracking ,Electroencephalography (EEG) ,Low resolution brain electromagnetic tomography (LORETA) ,Mild cognitive impairment (MCI) ,Aged ,Cerebral Cortex ,Cognitive Dysfunction ,Female ,Follow-Up Studies ,Humans ,Alpha Rhythm ,Neuroscience (all) ,Developmental Biology ,Geriatrics and Gerontology ,Neurology (clinical) ,medicine ,0501 psychology and cognitive sciences ,Cognitive decline ,Mini–Mental State Examination ,Resting state fMRI ,medicine.diagnostic_test ,General Neuroscience ,mild cognitive impairment (mci) ,05 social sciences ,electroencephalography (eeg) ,medicine.disease ,Settore MED/26 - NEUROLOGIA ,medicine.anatomical_structure ,Cerebral cortex ,Psychology ,Neuroscience ,030217 neurology & neurosurgery - Abstract
Cortical sources of resting state electroencephalographic (EEG) rhythms are abnormal in subjects with mild cognitive impairment (MCI). Here, we tested the hypothesis that these sources in amnesic MCI subjects further deteriorate over 1 year. To this aim, the resting state eyes-closed EEG data were recorded in 54 MCI subjects at baseline (Mini Mental State Examination I = 26.9; standard error [SE], 0.2) and at approximately 1-year follow-up (13.8 months; SE, 0.5; Mini Mental State Examination II = 25.8; SE, 0.2). As a control, EEG recordings were also performed in 45 normal elderly and in 50 mild Alzheimer's disease subjects. EEG rhythms of interest were delta (2-4 Hz), theta (4-8 Hz), alpha1 (8-10.5 Hz), alpha2 (10.5-13 Hz), beta1 (13-20 Hz), and beta2 (20-30 Hz). Cortical EEG sources were estimated using low-resolution brain electromagnetic tomography. Compared with the normal elderly and mild Alzheimer's disease subjects, the MCI subjects were characterized by an intermediate power of posterior alpha1 sources. In the MCI subjects, the follow-up EEG recordings showed a decreased power of posterior alpha1 and alpha2 sources. These results suggest that the resting state EEG alpha sources were sensitive-at least at the group level-to the cognitive decline occurring in the amnesic MCI group over 1 year, and might represent cost-effective, noninvasive and widely available markers to follow amnesic MCI populations in large clinical trials.
- Published
- 2014
42. Brains 'in concert': Frontal oscillatory alpha rhythms and empathy in professional musicians
- Author
-
Danilo Spada, Daniela Perani, Simone Rossi, Ivo Bruni, Claudio Babiloni, Paola Buffo, Paolo Maria Rossini, Claudio Del Percio, Fabrizio Vecchio, Nicola Marzano, Babiloni, C, Buffo, P, Vecchio, F, Marzano, N, Del Percio, C, Spada, D, Rossi, S, Bruni, I, Rossini, Pm, and Perani, DANIELA FELICITA L.
- Subjects
Questionnaires ,Adult ,Male ,Cognitive Neuroscience ,media_common.quotation_subject ,Emotions ,Alpha (ethology) ,Empathy ,Empathy quotient ,Electroencephalography ,Brain mapping ,Developmental psychology ,Young Adult ,Surveys and Questionnaires ,medicine ,Alpha rhythms ,Humans ,Expert musicians ,Electroencephalography (EEG) ,Occupations ,media_common ,Cerebral Cortex ,Brain Mapping ,Standardized low resolution brain electromagnetic source tomography (sLORETA) ,Resting state fMRI ,medicine.diagnostic_test ,Alpha Rhythm ,Brain ,Middle Aged ,Group Processes ,Music ,Neurology ,expert musicians ,professional musicians ,alpha rhythms ,standardized low resolution brain electromagnetic source tomography (sloreta) ,empathy ,electroencephalography (eeg) ,Cognition ,Settore MED/26 - NEUROLOGIA ,Test score ,Psychology ,Cognitive psychology - Abstract
article i nfo Playing music in ensemble represents a unique human condition/performance where musicians should rely on empathic relationships. Recent theories attribute to frontal Brodmann areas (BAs) 44/45 and 10/11 a neu- ral basis for "emotional" and "cognitive" empathy. We hypothesized that activity of these structures reflects empathy trait in professional musicians playing in ensemble. Simultaneous electroencephalographic (EEG) alpha rhythms (8-12 Hz) were recorded in three saxophone quartets during music performance in ensemble (EXECUTION), video observation of their own performance (OBSERVATION), a control task (CONTROL), and resting state (RESTING). EEG source estimation was performed. Results showed that the higher the empathy quotient test score, the higher the alpha desynchronization in right BA 44/45 during the OBSERVATION refer- enced to RESTING condition. Empathy trait score and alpha desynchronization were not correlated in other control areas or in EXECUTION/CONTROL conditions. These results suggest that alpha rhythms in BA 44/45 reflect "emotional" empathy in musicians observing own performance.
- Published
- 2012
43. Simultaneous recording of electroencephalographic data in musicians playing in ensemble
- Author
-
Fabrizio Vecchio, Claudio Babiloni, Danilo Spada, Ivo Bruni, Simone Rossi, Daniela Perani, Nicola Marzano, Francesco Infarinato, Paolo Maria Rossini, Paola Buffo, Babiloni, C, Vecchio, F, Infarinato, F, Buffo, P, Marzano, N, Spada, D, Rossi, S, Bruni, I, Rossini, Pm, and Perani, DANIELA FELICITA L.
- Subjects
Adult ,Male ,Cognitive Neuroscience ,Speech recognition ,music ,multi-subjects eeg recordings ,methods ,cooperative behavior ,male ,middle aged ,adult ,humans ,personality ,standardized low resolution brain electromagnetic source tomography (sloreta) ,empathy ,expert musicians ,electroencephalography ,cerebral cortex ,physiology ,alpha rhythms ,alpha rhythm ,electroencephalography (eeg) ,Posterior parietal cortex ,Experimental and Cognitive Psychology ,Electroencephalography ,Multi-subjects EEG recordings ,Software ,Alpha rhythms ,Electroencephalography (EEG) ,Expert musicians ,Standardized low resolution brain electromagnetic source tomography (sLORETA) ,Alpha Rhythm ,Cerebral Cortex ,Empathy ,Humans ,Middle Aged ,Personality ,Cooperative Behavior ,Music ,Neurology (clinical) ,Neurology ,medicine ,medicine.diagnostic_test ,Resting state fMRI ,business.industry ,Safety guidelines ,Settore MED/26 - NEUROLOGIA ,Neuropsychology and Physiological Psychology ,Amplitude ,Dynamics (music) ,Galileo (vibration training) ,business ,Psychology ,Neuroscience - Abstract
Here we describe a methodological approach for the simultaneous electroencephalographic (EEG) recording in musicians playing in ensemble. Four professional saxophonists wore pre-wired EEG caps (30 electrodes placed according to an augmented 10-20 system; cephalic reference and ground). Each cap was connected to a single multi-channel amplifier box [Brain Explorer (BE), EB-Neuro(©)]. The four boxes converged to a single workstation equipped with a software (GALILEO NT, EB-Neuro(©)) allowing the simultaneous recording of sounds, digital trigger, and EEG-electrooculographic (EOG)-electromyographic (EMG) data, and providing a separate output file for each individual. Noteworthy, the subjects were electrically decoupled to satisfy international safety guidelines. The quality of the EEG data was confirmed by the rate of artifact-free EEG epochs (about 80%) and by EEG spectral features. During the resting state, dominant EEG power density values were observed at alpha band (8-12Hz) in posterior cortex. The quality of EMG can be used to identify "on" and "off" states of the musicians' motor performance, thus potentially allowing the investigation of the relationships between EEG dynamics and different characteristics of the specific performance. During the music performance, alpha power density values decreased in amplitude in several cortical regions, whereas power density values enhanced within narrow high-frequency bands. In conclusion, the present methodological approach appeared to be suitable for simultaneous EEG recordings in musicians playing in ensemble.
- Published
- 2011
44. Sequential Subcutaneous Thymopentin, Interferon Alpha-2A and Interleukin-2 in Metastatic Renal Cell Cancer
- Author
-
Silvia Carpano, M. Lopez, L. Di Lauro, P Del Medico, T. Gionfra, M. Rosselli, Patrizia Vici, A. Cancrini, Iaffaioli, R. V., Tortoriello, A., Facchini, G., Caponigro, F., Marzano, N., Bucci, L., Fei, Landino, and Santangelo, M.
- Subjects
Adult ,Male ,Interleukin 2 ,Cancer Research ,Injections, Subcutaneous ,interferon alpha-2a ,Interferon alpha-2 ,Pharmacology ,renal cell cancer ,Drug Administration Schedule ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Interferon ,Antineoplastic Combined Chemotherapy Protocols ,medicine ,Carcinoma ,Humans ,Thymopentin ,Metastatic renal cell cancer ,Carcinoma, Renal Cell ,Interferon Alpha 2a ,Aged ,business.industry ,Interferon-alpha ,Drug Synergism ,General Medicine ,Middle Aged ,medicine.disease ,Kidney Neoplasms ,Recombinant Proteins ,Clinical trial ,Oncology ,030220 oncology & carcinogenesis ,Toxicity ,Immunology ,Interleukin-2 ,Female ,business ,medicine.drug - Abstract
To determine the activity of sequential administration of thymopentin (TP-5), interferon alpha-2a (IFN) and interleukin-2 (IL-2) in metastatic renal cell cancer (RCC), 17 patients with RCC were treated with TP-5 50 mg/d on days 1 to 14, IFN 3 MIU/d on days 14, 15, 21, 22 and IL-2 18 MIU/d on days 16 to 20, and 23 to 27. Treatment was given subcutaneously and cycles were repeated every 6 weeks. All patients were assessed for toxicity and response. No objective responses were observed. Two patients had a short-lived disease stabilization. Median survival was 9 months. Toxicity was generally moderate. The most important side-effects were related to IL-2 administration. In view of the lack of antitumor activity, the combination of TP-5 + IFN + IL-2 in the doses and schedule used in this trial cannot be recommended. The investigation of chemotherapeutic and immunological agents that can effectively synergize with IFN or IL-2 is essential.
- Published
- 1995
45. Phase I/II study of paclitaxel and vinorelbine in metastatic breast cancer
- Author
-
Antonio Citarella, Giacomo Benassai, Maria Carola, A. Tortoriello, Francesco Caponigro, G. Facchini, Giovanni Persico, Michele Santangelo, Rosario Vincenzo Iaffaioli, Nicola Marzano, Tortoriello, A., Facchini, G., Caponigro, F., Santangelo, M., Benassai, Giacomo, Persico, G., Citarella, A., Carola, M., Marzano, N., Iaffaioli, R. V., A., Tortoriello, G., Facchini, F., Caponigro, Santangelo, Michele, G., Persico, A., Citarella, M., Carola, N., Marzano, and R. V. I. a. f. f. a. i. o. l., I.
- Subjects
Adult ,Oncology ,Cancer Research ,medicine.medical_specialty ,Paclitaxel ,medicine.medical_treatment ,Hematopoietic growth factor ,Mammary gland ,Breast Neoplasms ,Neutropenia ,Vinblastine ,Vinorelbine ,chemistry.chemical_compound ,Breast cancer ,Internal medicine ,medicine ,Humans ,Neoplasm Metastasis ,Aged ,Chemotherapy ,business.industry ,Middle Aged ,medicine.disease ,Antineoplastic Agents, Phytogenic ,Metastatic breast cancer ,Surgery ,medicine.anatomical_structure ,chemistry ,Female ,metastatic breast cancer ,business ,medicine.drug - Abstract
23 citazioni: 22 su Scopus e una citazione presente in GoogleScholar ("Das Taxol-Buch" di Volker Bartsch THIEME Ed. 2004 ISBN 3-13-105462-X) ----- Paclitaxel and vinorelbine are among the most active new agents in metastatic breast cancer. Both in vitro and in vivo studies have shown that the combined administration of these two microtubule-targeting agents is feasible and worthwhile. Based on the promising preclinical data, patients with metastatic breast cancer no longer amenable to conventional treatment were entered into a phase I/II study in which the vinorelbine dose was fixed at 30 mg/sqm and paclitaxel was started at 90 mg/sqm and then subsequently escalated by 30 mg/sqm per step. Cycles were repeated every 21 days. Hematopoietic growth factor support was provided from the 4th dose level onwards. Grade III neutropenia was observed only in 2 patients treated at the 5th dose level. Thrombocytopenia never reached grade 3. Neurotoxicity was considered dose-limiting, since grade 3 peripheral neuropathy occured in all three patients treated at the 6th dose level. Other toxicities were mild. Paclitaxel 210 mg/sqm and vinorelbine 30 mg/sqm was the selected combination for phase II. Overall response rate in 34 evaluable patients was 38% (95% confidence interval (C.I.), 22% to 54%). In particular, 3 complete responses (9%) and 10 partial responses (29%) were observed. The observed level of antitumor activity, with an overall response rate of 38% and a median duration of response of 12 months, is of interest, since the study was targeted only to anthracycline-pretreated patients, most of whom had adverse prognostic features. The evaluation of a combination of vinorelbine and paclitaxel as first-line therapy in metastatic breast cancer seems worthwhile and is currently undergoing.
- Published
- 1998
46. Stop Flow in abdominal and pelvic cancer relapses
- Author
-
Roberto D'Angelo, Di Salvo E, Giovanni Romano, Iaccarino, G. Facchini, Michele Santangelo, Francesco Fiore, Emiddio Barletta, Rosario Vincenz Iaffaioli, A. Tortoriello, S. Guadagni, Massidda B, Memeo, Parisi, F. Crovella, Daniele B, B Memoli, Giovanni Mantovani, N. Marzano, Giuseppe Colucci, Pilati Pl, Rossi R, Sandro Pignata, Mallarini G, R. Formato, Rosati G, Marcello Deraco, Iaffaioli, Rv, Facchini, G, Tortoriello, A, Crovella, F, Romano, G, Formato, R, Santangelo, Michele, Barletta, E, Fiore, F, Iaccarino, Vittorio, Memoli, Bruno, D'Angelo, R, Pilati, Pl, Rossi, R, Guadagni, S, Deraco, M, Pignata, S, Daniele, B, Rosati, G, Massidda, B, Mantovani, G, DI SALVO, Enrico, Marzano, N, Memeo, V, Parisi, V, Mallarini, G, and Colucci, G.
- Subjects
Genetics and Molecular Biology (all) ,Adult ,Male ,medicine.medical_specialty ,Maximum Tolerated Dose ,Mitomycin ,Phases of clinical research ,Biochemistry ,Gastroenterology ,Pelvis ,Dose finding ,Pain control ,Recurrence ,Internal medicine ,Antineoplastic Combined Chemotherapy Protocols ,medicine ,Stop-flow ,Humans ,Cancer ,Aged ,Pelvic Neoplasms ,Tumor ,Dose-Response Relationship, Drug ,business.industry ,Systemic chemotherapy ,Stop flow ,Pelvic relapses ,Pelvic cancer ,Cell Biology ,Hydrogen-Ion Concentration ,Middle Aged ,medicine.disease ,Surgery ,medicine.anatomical_structure ,Treatment Outcome ,Doxorubicin ,Chemotherapy, Cancer, Regional Perfusion ,Disease Progression ,Neoplasm ,Female ,business ,Relapses ,Biochemistry, Genetics and Molecular Biology (all) - Abstract
To determinate MTD, DLT and safe doses for phase II study, a dose finding study with Mitomycin and Adriamycin Stop-Flow administration was carried out. A phase II study focused on resectability of pelvic colorectal relapses is in progress. From November 1995, 84 pts, 52 male and 32 female (94 treatments), with advanced not resectable abdominal (14 pts) or pelvic (70 pts) relapses, and resistant to previous systemic chemotherapy, were enrolled in the study. 46 pts entered the phase I-early phase II study, while subsequently 38 pts were recruited in ongoing phase II study. Safe dose were: MMC 20 mg/mq and ADM 75 mg/mq. The phase II study focused on colorectal relapses registered very promising responses: 90% pain control, 1 pCR and 26 PR / 63 (OR 43%), 8 NC (13%) 9/27 responder patients (33%) obtained a complete resectability of colorectal relapses. Stop-Flow is a safe and feasible technique very useful as a palliation treatment.
47. The Core Competencies in Hospital Medicine-Clinical Conditions 2023 Update Methodology.
- Author
-
Nichani S, Brooks M, Fitterman N, Lukela M, Marzano N, Sopko K, and Sweigart J
- Subjects
- Humans, Curriculum, Hospital Medicine, Hospitalists
- Abstract
As hospital medicine continues to evolve, the Society of Hospital Medicine (SHM) recognizes the importance of periodic re-evaluation and adaptation of The Core Competencies in Hospital Medicine to reflect and guide the continual expansion of hospitalists' scope of practice. Since its first publication in 2006, the Core Competencies were last revised in 2017 to reflect existing practice. The Core Competencies were initially developed to describe hospitalists' roles and expectations and identify growth opportunities. As hospital medicine has expanded, SHM seeks to maintain the Core Competencies as a framework to guide curricular development, enhance practice assessment, improve the quality of care, and cultivate systems-based practices. Additionally, it helps elucidate the clinical and systems-based aspects central to the field. Thus, the new chapters in the 2023 clinical conditions update focus on enhancing individual hospitalist practice in evaluating and managing common clinical conditions. The accompanying article describes the chapter review and revision process and the criteria for new chapter selection., (© 2023 The Authors. Journal of Hospital Medicine published by Wiley Periodicals LLC on behalf of Society of Hospital Medicine.)
- Published
- 2023
- Full Text
- View/download PDF
48. An art therapy group intervention for cancer patients to counter distress before chemotherapy.
- Author
-
De Feudis RL, Graziano G, Lanciano T, Garofoli M, Lisi A, and Marzano N
- Subjects
- Adult, Female, Humans, Male, Middle Aged, Surveys and Questionnaires, Antineoplastic Agents, Art Therapy, Neoplasms psychology, Stress, Psychological therapy
- Abstract
Background : The aim of this study was to investigate the feasibility and effectiveness of a single group session based on art therapy (AT) for adult cancer patients to reduce anxiety and distress before anticancer treatment. Methods : A non-randomized pre-post study design was adopted. Sixty-two patients took part in one of twenty-seven "one-off" sessions held over a four-month period. Sixty-six patients, who simply received routine medical treatment, served as the control group (CG). Results : The intervention was appropriate to patients' needs and feasible in the context of their routine medical care. In contrast to the CG, the intervention group(IG) participants demonstrated a decrease in symptoms of anxiety, drowsiness and tiredness. Conclusions : The intervention proved suitable to the medical routine of patients' care. The clinical implications of the AT protocol and future research aimed at testing it vs. a different type of psychosocial intervention in a randomized controlled study are discussed.
- Published
- 2021
- Full Text
- View/download PDF
49. Experience-optimised fast track improves outcomes and decreases complications in total knee arthroplasty.
- Author
-
Ascione F, Braile A, Romano AM, di Giunta A, Masciangelo M, Senorsky EH, Samuelsson K, and Marzano N
- Subjects
- Aged, Aged, 80 and over, Blood Transfusion, Female, Humans, Knee Joint surgery, Male, Middle Aged, Operative Time, Patient Discharge, Patient Readmission, Postoperative Complications physiopathology, Prospective Studies, Arthroplasty, Replacement, Knee adverse effects, Elective Surgical Procedures adverse effects, Knee Joint physiopathology, Patient Satisfaction, Postoperative Complications prevention & control, Range of Motion, Articular physiology
- Abstract
Purpose: The aim of this study was to describe an advanced total knee arthroplasty (TKA) fast-track programme and determine discharge parameters during hospitalisation, as well as patient satisfaction, outcomes and complications within the first 12 months after surgery., Methods: This prospective study was based on patients selected consecutively for primary elective TKA, undergoing surgery between 2014 and 2017 in an established fast-track setting. Hospitalisation-related parameters were collected: demographics, body mass index (BMI), surgical time, ischaemia time, haemoglobin values, blood transfusions, length of stay, weight-bearing and stair-climbing time, opioid administration, preoperative and discharge loss of extension and maximum active flexion of the knee, visual analogue scale (VAS), 12-month follow-up satisfaction rate and range of motion, any complications, hospital re-admission and re-operation within the first 12 months. Differences were determined using t-tests., Results: A total of 704 total knee replacements implanted in 481 patients were included in the study and 223 patients had a bilateral TKA. Their mean age was 69.8 years (range 57-88 years). At the 12-month follow-up, 623 patients (88.5%) reported being satisfied or very satisfied and 15 (2.1%) were dissatisfied with their TKA, mean active flexion and loss of extension were 104.4° and 2.3°, respectively. A total of 15 complications occurred (two percent): five painful knees, three knee stiffness, three haematomas, two infections, one hospital re-admission and one deep venous thrombosis. No cases of pulmonary embolism and death related to surgery were reported., Conclusion: The study reports on an advanced fast-track programme for TKA with a low incidence of surgery- and hospitalisation-related issues and complications and without any severe adverse events during the first year. On average, the fast-track programme had a short length of stay, an early recovery of weight-bearing, knee mobility, pain control and a high satisfaction rate, accompanied with an acceptable 12 month range of motion., Competing Interests: Declaration of competing interest The authors declare that they have no conflicts of interest., (Copyright © 2019 Elsevier B.V. All rights reserved.)
- Published
- 2020
- Full Text
- View/download PDF
50. Prevalence, characteristics, and treatment of fatigue in oncological cancer patients in Italy: a cross-sectional study of the Italian Network for Supportive Care in Cancer (NICSO).
- Author
-
Roila F, Fumi G, Ruggeri B, Antonuzzo A, Ripamonti C, Fatigoni S, Cavanna L, Gori S, Fabi A, Marzano N, Graiff C, De Sanctis V, Mirabile A, Serpentini S, Bocci C, Pino MS, Cilenti G, Verusio C, and Ballatori E
- Subjects
- Adult, Aged, Aged, 80 and over, Anxiety complications, Cancer Pain complications, Cross-Sectional Studies, Depression complications, Exercise psychology, Exercise Therapy, Fatigue therapy, Female, Humans, Italy epidemiology, Male, Middle Aged, Prevalence, Quality of Life, Surveys and Questionnaires, Young Adult, Fatigue epidemiology, Fatigue etiology, Neoplasms complications
- Abstract
Background: Fatigue is one of the most distressing symptoms of cancer patients. Its characteristics and impact on quality of life have not been fully explored and treatment of cancer-related fatigue in Italian oncological centers has not been codified., Methods: A cross-sectional study was carried out on all patients attending for any reason the 24 participating centers in two non-consecutive days. Patients with fatigue filled out the Brief Fatigue Inventory (BFI) questionnaire and reported any pharmacological or non-pharmacological treatment for fatigue., Results: From October 2014 to May 2015, 1394 cancer patients agreed to participate in the study. Fatigue was referred by 866 (62.1%) of patients; its duration was > 4 months in 441 patients (50.9%). In the investigators' opinion, the most important (probable or almost sure) determinants of fatigue were reduced physical activity (271 patients), anxiety (149), pain (131), insomnia (125), anemia (123), and depression (123). Fatigue of moderate/severe intensity was reported by 43%/29.2% of patients, while usual fatigue in the last 24 h by 45%/33.1%, and the worst fatigue in the last 24 h by 33%/54.8%, respectively. Concerning the impact on quality of life, fatigue interfered moderately/severely with general activity in 30.8%/38.6% of patients, with mood in 26.1%/32.8%, with the ability to work in 27.9%/35.6%, with normal work in 26.7%/38.9%, with relationships with others in 21%/23.4% and with the ability to amuse themselves in 22.2%/33.1%. Only 117/866 patients (13.5%) received a pharmacological treatment represented by a corticosteroid in 101 patients (86.3%) while 188 patients (21.7%) received a non-pharmacological treatment such as physical exercise (120 patients, 63.8%) and various alimentary supplements (52 patients, 27.6%)., Conclusions: Cancer-related fatigue is frequently reported by oncological patients; its intensity and impact on quality of life is relevant.
- Published
- 2019
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.