1. Comparison of Abbott Architect ® , Siemens Immulite ® , and Diasorin Liaison ® for determination of Epstein–Barr virus serological diagnosis
- Author
-
Etienne Brochot, Sandrine Castelain, Patricia Zawadzki, Denise Hecquet, Catherine Roussel, Christine Pannier, Christine Segard, Martine Stefanski, Maryline Bouvier, Gilles Duverlie, and Catherine François
- Subjects
0301 basic medicine ,Microbiology (medical) ,Siemens Immulite ,medicine.diagnostic_test ,business.industry ,030106 microbiology ,General Medicine ,medicine.disease_cause ,University hospital ,Epstein–Barr virus ,Virology ,Virus ,Serology ,03 medical and health sciences ,030104 developmental biology ,Infectious Diseases ,Blood serum ,Antigen ,hemic and lymphatic diseases ,Immunoassay ,Immunology ,medicine ,business - Abstract
This study compared the performance of 3 automated immunoassays, Architect® (Abbott), Immulite® (Siemens) and Liaison® (Diasorin), for Epstein-Barr virus (EBV) serology. Ninety-one serum samples collected in Amiens University Hospital were analyzed for the presence of Viral Capsid Antigen (VCA) IgG and IgM and Epstein-Barr Nuclear Antigen (EBNA) IgG. The agreement between the 3 assays was calculated for each marker individually and for determination of the EBV profile, based on interpretation of the combination of these 3 EBV markers. Although similar results were obtained with Architect® and Liaison®, several discordant results were observed with Immulite®, particularly for EBNA IgG. A large number of EBNA IgG-positive results were observed, which interfered with interpretation of the EBV profile. In contrast, Immulite® performed similarly to the 2 other assays for detection of VCA IgM.
- Published
- 2018
- Full Text
- View/download PDF