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1. Prevalence of Minor β-thalassemia Based on RBC Indices among Final Suspected Individuals in Premarital Screening Program Referred to Genetic Laboratories

Author

Alireza Moafi, Sadeg Valian, Zahra Nikyar, Mehrdad Zeinalian, Maryam Momenzadeh, and Soheila Rahgozar

Subjects
Minor β-Thalassemia, Screening, MCH, MCV, Thalassemia Preventing Program, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

"nAbstract "nIntroduction: The current study evaluated the value of red blood cell (RBC) indices and the corresponding cut- off points for β-thalassemia control programs in Iran. "nMaterials and Methods: 1,150 individuals (575 couples) with low RBC indices and normal hemoglobin A2 who had been referred to the Genetic Centre of Isfahan, were tested during pre-marital screening analyses, in the 2 year period, 2006-2008. β-thalassemia mutations were evaluated. "nResults: β-thalassemia was identified in 67.8% of the cases with both mean corpuscular volume (MCV) less than 78fl and mean corpuscular hemoglobin (MCH) less than 26 pg. However, 4.1% of the individuals with "n78≤ MCV≤ 80 tested positive for thalassemia. MCV showed a higher diagnostic reliability than MCH. However, the accompaniment of MCH

Published
2010

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