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The purpose of this study is to evaluate a treatment for aluminum phosphide (ALP) poisoning, which is known as “rice tablet”. Methods: In the present study, the impact of different doses of ethanolic extract of olive leaves (100, 200, and 400 mg/kg) on ALP (120 mg/kg)-induced cardiotoxicity was evaluated in anesthetized-gastrotomized adult male Wistar rats. Thirty-five rats were randomly assigned into five groups (n=7) as follows: control (AC) and treatment groups [ALP+Olea100 (AO100), ALP+Olea 200 (AO200), and ALP+Olea 400 (AO400)]. Physiological data including blood pressure, heart rate, electrocardiogram (ECG), as well as oxidative stress markers were measured in heart tissues. Results: ALP-intoxication led to perturbed normal ECG and increased oxidative stress. Administration of olive leaf extract at various concentrations, however, mitigated bradycardia after 90 minutes, following ALP-intoxication (in AO200), hypotension (in AO100), and cardiac conduction disturbances (decreased QTC in the AO200 30 (P

Background: Lipopolysaccharide (LPS) as a particle of Gram-negative bacteria is a main contributer in the pathogenesis of the male reproductive system infectious. Male infertility due to LPS is reported to be related to overproduction reactive oxygen species. This study aimed to investigate the effects of olibanum on oxidative stress and apoptosis in testes and sperm dysfunction induced by LPS. Methods: The male (n = 28) rats were allocated in four groups: control, LPS (1 mg/kg, i.p., 14 days), LPS + Olibanum 100 (100 mg/kg, i.p., 14 days), and LPS + Olibanum 200 (200 mg/kg, i.p., 14 days). Germ cell apoptosis was determined by TUNEL assays and computed using the stereological method. Additionally, semen samples of the animals were analyzed for sperm count and morphology. Oxidative stress indicators were also determined. Results: The count of TUNEL-positive germ cells in LPS-treated rats was more than that in the controls. Treatment of the animals with olibanum significantly attenuated the number of apoptotic cells compared to the LPS group. The sperm count and those with a normal morphology in LPS-treated rats was lower than that in the controls. Administration of olibanum significantly improved the sperms with normal morphology and sperm count. Olibanum treatment also improved superoxide dismutase, catalase, and total thiol in testicular tissue and decreased malondialdehyde. Conclusion: Administering both doses of olibanum in LPS-treated rats had potentially a therapeutic value in reducing germ cell apoptosis, as well as improving sperm parameters.

Background: Based on the evidence, Patients with coronary artery disease have unstable blood pressure and low action flexibility, which causes disease recurrence and increased risk of death. Based on previous studies, Interpersonal therapy can help treat disorders in chronic patients, However, there is a research gap regarding the effectiveness of this type of treatment on action flexibility and blood pressure of women with coronary artery disease. Aims: The current study aims to determine the efficacy of interpersonal psychotherapy on action flexibility and blood- pressure in women with coronary artery disease. Methods: The current study was a quasi-experimental pre-test-post-test type with a control group and a follow-up period (45 days). The statistical population of the study includes all female patients with coronary artery disease who had an appointment at the Cardiac Rehabilitation in Afshar Clinic of Yazd in 2021; 28 of them were selected in a targeted method and replaced by random assignment in the groups. Data collection tools include Action flexibility questionnaire (Connor & Davidson, 2003) and sphygmomanometer. The data was analyzed using mixed variance analysis and SPSS24 software. Results: According to the results obtained, interpersona psychotherapy significantly affects the flexibility of patients' actions (P>0.05). Although this treatment had a significant effect on systolic and diastolic blood pressure at the end of the interventions, this effect was not effective in the follow-up stage (p

Background: Incivility is a kind of disrespect to people. Students and faculty members agree on the growing trend of incivility. Uncivil behaviors in online nursing classes are a serious global issue that can influence the learning-teaching process and threaten patient safety in the clinical setting. This study aimed to identify incivility in the online learning environment from the perspective of nursing faculty members and students.Methods: This descriptive qualitative study was conducted in 2021. A total of 20 participants were selected from among nursing students and faculty through purposive sampling. Data were collected using in-depth semi-structured interviews and analyzed via a qualitative content analysis approach.Results: Data analysis revealed five categories including ghost students, unconditional freedom, disruptive learning behaviors, academic dishonesty, and ignoring the rules of the online learning environment.Conclusion: Incivility in the online learning environment disrupts the teaching-learning process and undermines instructor-student relationships. Given that disrespectful and threatening behaviors, even to a small degree, can significantly affect the learning environment, it is essential to recognize such behaviors. As uncivil behaviors in virtual nursing education can affect education by developing inappropriate behavioral and communication patterns in students, leading to the violation of professional ethics and patients’ rights, it is necessary to pay attention to this critical issue by conducting further studies and designing interventions to correct it.

Background: This study aimed to determine whether syzygium aromaticum (clove) could help polycystic ovarysyndrome (PCOS) rats.Materials and Methods: In this experimental study, forty adult female Wistar rats (weighing 250 ± 10 g) were dividedrandomly into five groups; G1: control, G2: PCOS group, G3: PCOS+clove (30 mg/kg/ orally/daily) group, G4:PCOS+clove (60 mg/kg/orally/daily) group, and G5: PCOS+gonadectomy group. The PCOS was induced by a singledose injection of estradiol valerate (16 mg/kg/IM). Following PCOS induction, the rats were treated for 14 days. Histologicalparameters, follicle apoptosis, mRNA expression of autophagy markers (Lc3, Beclin1), oxidative stress markers,insulin and blood glucose levels, as well as serum levels of aromatase and testosterone were evaluated in these rats.Finally, the ratio of serum luteinizing hormone (LH) to follicle-stimulating hormone (FSH) levels was also calculated.Results: The autophagy markers (Lc3, Beclin1), histological parameters, oxidative stress, insulin, and hormone levelschanged significantly in the PCOS rats (G2). In G3 and G5 groups, it was observed that the levels of LH/FSH and testosteronedecreased significantly in comparison to the PCOS group, and inhibition of autophagy was also observed inthese groups. Treatment with cloves in the G3 group significantly improved oxidative stress, histological parameters,and insulin levels.Conclusion: These findings demonstrated that oxidative stress, apoptosis, and excessive autophagy could be improvedby treatment with low doses of clove and gonadectomy. Cloves may help to improve these parameters by regulating andinhibiting excessive autophagy. However, discovering the direct role of this extract in regulating the parameters suchas oxidative stress, insulin, and androgens requires further investigation. In the present study, P

Background and Objective: We are witnessing a marked increase in demand for outpatient services. Patients experience health-related anxiety, which exerts destructive effects on the treatment. The control and management of this anxiety create confidence in health services. The present study aimed to determine the effect of nursing counseling on health anxiety and its relationship with trust in nursing services in the outpatient department. Materials and Methods: In this quasi-experimental study conducted in 2021, 60 participants were randomly selected from the outpatient department of a clinic and assigned to two groups: intervention and control. Data collection tools were a demographic information questionnaire, Alkovskis and Warwick Health Anxiety, and Trust in Nurses Scale (TNS) (Radwin and Cabral, 2010). The participants answered demographic and health anxiety questionnaires. After the visit, the intervention group received nursing counseling, while the control group only received routine training. One week later, the participants answered the health anxiety questionnaire and trust in nurses scale again. Data were analyzed in SPSS software (version 18) using descriptive and inferential statistical tests. Results: The mean of health anxiety before the consulting was not significantly different between the two groups (P=0.20); nonetheless, after the consulting, the intervention group obtained a lower mean score compared to the control group (P>0.001). There was a significant difference between this mean before and after consulting in the intervention group (P>0.001). There was a significant positive relationship between receiving nursing counseling and confidence in nursing services (P>0.001) (C.V=-0.145). Conclusion: As evidenced by the results of this study, the provision of nursing consultation reduces patients' health anxiety and increases confidence in nursing services. It is suggested to pay attention to this role of nurses in outpatient departments.

Abstract Background Nursing students are required to acquire the necessary clinical knowledge and skills to provide safe and quality care. The method of providing training, particularly for final-year nursing students, is of utmost importance. An internship is a program during which students work in shifts similar to nurses employed in a hospital; however, the number of their shifts and patients is less than nurses; a nurse and the faculty supervise the care they provide, and they are paid a monthly salary. This study was conducted to explore nursing faculty, managers, new graduates, and students’ experiences of nursing internship program implementation. Methods This descriptive qualitative study was conducted from November 2021 to March 2022. The participants were selected from among nursing managers, newly graduated nurses, nursing internship students (final-year undergraduate), and faculty of Iran. Data were collected using in-depth semi-structured interviews. The qualitative content analysis approach was used for data analysis. Results Participants in this study included 17 nursing internship students, 12 nursing managers, three faculty members, ten nursing preceptors, and five newly graduated nurses from the internship program, 47 participants in total. After analyzing the data, five themes, including ‘facilitation of socialization process,’ ‘filling the gap between theory and practice,’ ‘improving self-confidence and independence,’ ‘an opportunity for clinical skill training,’ and ‘Achilles’ heel of the clinical setting,’ and nineteen subthemes were extracted from the participants’ experiences. Conclusion Implementation of an internship program for final-year nursing students plays a role in preparing them for better professional performance, enhancing clinical skills, increasing self-confidence and independence, inspiring the nursing profession, strengthening professional commitment, and improving the chances of employment after graduation. In order to alleviate the identified challenges of the internship program, holding a briefing meeting with managers, supervisors, and faculty to determine working hours, performance standards, and amenities such as lunch, dinner, and resting place is efficient.

Abstract Background Weaning the patient from mechanical ventilation (MV) is one of the common treatments in intensive care units (ICU). Among the factors that can complicate the weaning process are psychological problems caused by a lack of family visits. Objective This study aimed to evaluate the effect of scheduled visiting on weaning from mechanical ventilation in patients with brain injury admitted to ICUs. Methods This quasi-experimental study was performed on 60 patients with brain injury referred to one of the hospitals in Central Province, Iran in 2020. The selection of samples based on inclusion criteria and random allocation to the two groups of intervention and control by permuted block randomization was done. The first-degree relatives of the patients at the time of weaning in the intervention group were present at the patient’s bedside twice a day at 10:00 AM and 3:00 PM for 30–45 min and performed what they had been trained to do. Participants in the control group visited patients from the area outside the patient room. Length of weaning, length of mechanical ventilation, and length of stay in the ICU were recorded and measured using a researcher-conducted checklist. The results were analyzed using descriptive and inferential statistics and chi-square and independent t-tests in SPSS16. Results The study results showed that the number of patients weaned from mechanical ventilation in the intervention group was significantly higher than that of the control group (P ≤ 0.05). The mean length of weaning in the intervention and control groups was not statistically significant, but it was clinically significant in the intervention group (P > 0.05). In addition, the length of mechanical ventilation and the length of stay of the intervention group in the ICU were significantly shorter than that of the control group (P ≤ 0.05). Conclusion According to the study results, scheduled visiting resulted in faster weaning from mechanical ventilation. As a result, nurse managers are suggested to make arrangements for family members to be present at the patient’s bedside in order for patients to be weaned off the mechanical ventilator more easily.

Background: The ovarian Ischemia/reperfusion is one of the gynecological emergency concerns that may lead to the ovary damage and folliculogenesis. The present research aimed to evaluate the impact of the Chrysin (CH) on the ischemia-reperfusion (I/R) injury in the rat model.Materials and Methods: In this experimental research, 48 adult female rats, 8 weeks age and 180-200 g weight, have been categorized into 6 equal groups (n=8) including one sham and 5 ovarian torsion groups (OT+CH groups) that received different treatments. Each group has been treated 30 min before detorsion with gavage of CH or normal saline for 1 week and pregnant mare serum gonadotropin (PMSG) has been injected on the day 5 for initiating folliculogenesis. Finally, bio-chemical, molecular, histopathological, apoptotic and hormonal evaluations were performed.Results: The anti-oxidant enzyme, superoxide dismutase and glutathione peroxidase, ameliorated in the ovarian tissues of the OT+CH groups in comparison with the OT group (P

Background and Objective: This study aimed to determine the relationship of patient safety culture with social intelligence and psychosocial factors in the workplace among nurses working in the pediatric wards of West Guilan hospitals, Iran, in 2020. Materials and Methods: In this descriptive-correlational cross-sectional study, 130 nurses working in the pediatric wards of West Gilan hospitals in 2020 were selected using the availability sampling method. The required data were collected using the Hospital Survey on Patient Safety Culture, Social Intelligence Questionnaire (Silura et al., 2001), and the Psychosocial Factors Questionnaire (Christensen et al., 2005). Finally, the collected data in SPSS-23 statistical software were analyzed at both descriptive and inferential levels. Results: The results showed that patient safety culture, social intelligence, and psychosocial factors were at lower than average, higher than average, and average levels, respectively, in nurses working in the pediatric wards of West Gilan hospitals in 2020. There were significant relationships between patient safety culture and social intelligence (r=0.756) and between patient safety culture and psychosocial factors in the workplace among the studied nurses (r=0.878). Conclusion: Based on the findings, patient safety culture had a positive relationship with social intelligence and psychosocial factors in the workplace among nurses working in the pediatric wards of West Gilan hospitals in 2020.

Background: A large number of studies point to the widespread low level of subjective well-being in patients with coronary artery disease, especially in women. Although the Compassion-Focused Therapy has been an effective treatment in enhancing the ability to become sensitive to suffering along with trying to heal, the Interpersonal Psycho-Therapy also focuses on changing and modifying interpersonal relationships through positive therapeutic alliance; so, can the short-term IPT improve these patients' subjective well-being as well? Aims: The present study tries to compare the effectiveness of compassion-focused therapy and interpersonal psychotherapy on Women's Subjective well-being suffering from coronary artery disease. Methods: This study was a quasi-experimental study with a pre-test-post-test-follow-up design and a control group. The statistical population of the study consisted of all female patients referring to the Cardiac Rehabilitation Clinic of Afshar Hospital in Yazd. A total of 41 patients were purposefully selected and randomly assigned to two experimental groups and a control group. The instrument of this study was Keys and Magyarmo's (2003) Subjective Well-Being Scale For the first experiment group, the compassion-focused therapy (Gilbert, 2014, 2010), and for the second experiment group, the and interpersonal psychotherapy (Weissman, 2007) were delivered in groups and in eighat 90-minute sessions, but the control group received no intervention. The data were analyzed using the mixed variance analysis. Results: The results showed that the CFT and IPT increased the subjective well-being and its components at the end of the intervention and the follow-up period (P

Background and Objective: There is some degree of hypoxia in many cyanotic heart diseases that cannot be diagnosed with the naked eye. The measurement of arterial blood oxygen saturation at birth is a convenient and valuable procedure. Therefore, the present study aimed to investigate the arterial blood oxygen saturation of healthy newborns and its relationship with the family history of congenital heart disease and maternal demographic variables. Materials and Methods: In this cross-sectional descriptive study, 120 healthy neonates were selected via the convenience sampling method. Upon discharge, right-hand pulse oximetry was performed on the subjects. In the case of 90%-95% arterial blood oxygen saturation, one hour later, control was performed again. With a similar result, a referral to a cardiologist was made. Data were analyzed in SPSS software using descriptive and inferential (linear and multivariate regression) tests. Results: The mean arterial oxygen saturation of neonates was 98.13±1.95%. The number of deliveries and the history of heart disease in first-degree relatives had a significant relationship with the saturation results (P

Background and Aim: The aim of this study was to investigate the effect of Origanum vulgare administration on testicular injury induced by torsion/detorsion . Materials and Methods: In this experimental study, 64 adult rats were divided into 8 equal groups, as following:1-Sham: the abdominal cavity was opened and then closed. 2.Torsion/detorsion: the rats underwent spermatic cord twisting for 4 hours and then untwisting (30 minutes before untwisting normal saline was injected). 3.Torsion/detorsion+ Origanum vulgare: Similar to group 2, the only difference was injections of Origanum vulgare with different doses (400 mg/kg, 250, 100) which were given to 3 separate groups. 4. Origanum vulgare recipient: without any surgery, injections of Origanum vulgare were given to 3 separate groups with different doses (400 mg/kg, 250, 100). Twenty-four hours after surgery, blood samples were taken to measure oxidative stress factors. Testicular tissue was removed for assessment of histological changes, and the epididymis tissue was used to measure sperm parameters. Data were analyzed by SPSS software. Results: We found significant decreases in Johnson's score, epithelium height, and seminiferous tubule diameter (data obtained from histological examination), number and morphology of sperm parameters and oxidative stress factors (Malondialdehyde, Superoxide dismutase, Glutathione Peroxidase and, Catalase) in the torsion/detorsion group compared to those in the sham group (P= 0.0001), while they improved in the torsion/detorsion groups receiving Origanum vulgare group compared to those in the torsion/detorsion group, but in most cases, the results were not significant. Conclusion: It seems that Origanum vulgare can partially reduce the damage caused by testicular torsion/detorsion.

Background & Aims: Living with a temporary or permanent ostomy affects the quality of life (QoL) of people with an ostomy and requires increasing patients' self-efficacy to take care of themselves. Education is one way to improve individuals' QoL and self-care. Therefore, this study aimed to determine the effectiveness of distance self-care education on self-efficacy and QoL of patients with an intestinal ostomy in patients referred to Kermanshah hospitals in 2020-2021. Materials & Methods: In a quasi-experimental study before and after the process, 61 patients with intestinal ostomy referred to Imam Reza (AS), and Taleghani hospitals in Kermanshah province were selected from April to July 2021, using a simple sampling method. The samples first answered the self-efficacy questionnaires of ostomy patients and the quality of life of Weir and Sherborn. Then, the self-care program developed in the form of 8 45-minute group sessions was taught to patients by the researcher through discussion and conversation through a virtual network (WhatsApp), according to which they can use self-care at home, and two months after the end of the intervention. The mentioned questionnaires were distributed and completed among the patients again. Data were reported using SPSS software v. 20, and paired t-test and Wilcoxon tests were used for statistical analysis. Results: The Mean±SD of patients' QoL before the intervention was 34.05±16.53, reaching 49.63±21.59 after the intervention. Based on paired t-test, this difference was significant (P

Background: In Iran, many efforts have been made to improve the Quality of Life (QOL) of the elderly; however, despite the efforts made, there is no practice guideline based on the consensus of experts that can be used to prevent the functional decline of hospitalized elderly. Accordingly, the present study was conducted with the aim of adaptation of a practice guideline to prevent the functional decline of hospitalized elderly. Materials and Methods: This study is a developmental study based on the adaptation steps of the practice guideline. First, a search was conducted in 8 databases. The only practice guideline that met the inclusion criteria was then evaluated by the research team using the Appraisal of Guidelines for REsearch and Evaluation (AGREE II) tool. After content analysis of this guideline, the recommendations were categorized in the Canadian Senior Friendly Care (sfCare) Framework and according to the community conditions. Relevant evidence was used to supplement the content. The draft practice guideline was evaluated and modified in two expert panels through the RAND technique. Results: The categorized recommendations were developed in the eight chapters of introduction to the prevention of functional decline of the elderly, general practice guideline, organizational support, care processes, physical ecology, emotional and behavioral environment, ethics in care, and evaluation of function. Conclusions: To prevent functional decline in hospitalized elderly individuals according to the adaptive practice guideline, the hospital and health team need to be aware of support, care processes, and effective function appraisal to be able to provide care with coherent and coordinated solutions.

Background: Minocycline is a widely used bacteriostatic antibiotic with various functions. The aim of this study wasto investigate impact of apoptotic genes in ovary of the torsion/detorsion treated rat model by minocycline.Materials and Methods: This experimental study was performed in 32 female Wistar rats classified in four groups,including: i. sham, ii. TD: torsion/detorsion group received normal saline, iii. TDM: torsion/detorsion group treatedwith 40 mg/kg Minocycline, and iv. MC: healthy group received 40 mg/kg Minocycline. After treatment period (7days), histoplogical parameters, oxidative stress markers and hormone profile of serum as well as the expression ofBax and Bcl-2 genes were measured in the ovary of rats.Results: Levels of superoxide dismutase (SOD), glutathione peroxidase (GPX) and estrogen were decreased in theTD group and significantly increased in the treated groups (P=0.001). Levels of malondialdehyde (MDA) and testosteronewere increased in the TD group and decreased in the treated groups (P=0.001). Expression level of Bax waselevated in the TD group, while it was attenuated in the treated groups (P=0.001). Expression level of Bcl-2 wassignificantly increased in treated groups (P=0.001).Conclusion: Minocycline can repair oxidative damage in ovarian tissue and regulate apoptotic-related gene expressions.

Background and purpose: Due to the high rate of diabetes in the community and the importance of herbal supplements and exercise in its treatment, the present study aimed at evaluating the effects of hydroalcoholic extract of olive leaf on coronary artery function in streptozotocin-induced diabetic male rats with and without exercise training. Materials and methods: In this experimental study, 50 male Wistar rats (250-300 g) were randomly divided into five groups (n=10 per group): 1. Healthy control (CO), 2. Diabetic control (DC), 3. Diabetic control + Exercise training (DC+EX), 4. Diabetic control + Olea europaea L. (D+OIL), 5. Diabetic + exercise training + Olea europaea L. (DC+EX+OIL). Diabetes was induced by intraperitoneal injection of nicotinamide-streptozotocin. The rats in D+OIL and DC+EX+OIL groups performed submaximal exercise on treadmill for 5 days a week/ 8 weeks and received 200 mg/kgbw Olea europaea L. extract by gavage at 8 AM daily for 8 weeks. Twenty-four hours after the last training session, Isolated hearts were perfused using the Langendorff method and hemodynamic parameters were assessed. Then, levels of antioxidant enzymes and lipoproteins in the blood were measured. Results: Olive leaf extract with 8 weeks of exercise training led to increased activity of superoxide- dismutase and catalaseenzymes and increased lipoprotein levels of LDL and HDL in diabetic rats but it had no effect on improving LDL levels. It also prevented increased response to coronary artery stenosis due to diabetes and increased response to coronary artery dilator. Conclusion: Current study could be helpful in increasing the tendency to use exercise and olive leaf extract in treatment of diabetic patients and preventing cardiovascular complications including coronary artery endothelial disorders in these patients.

Background and purpose: Morphine as an opioid compound has different and sometimes conflicting effects on memory and learning process. Bile duct ligation causes cholestasis, which disrupts liver function. It is known that opioid systems are involved in cholestasis. The aim of this study was to investigate the possible effect of morphine on the memory of cholestatic rats. Materials and methods: In this experimental study, the cholestatic model in male Wistar rats (weighing 200-250 g) was induced by bile duct ligation (BDL). The animals were injected with morphine (4 and 6 mg/kg, ip), naloxone (0.6 and 0.8 mg/kg, ip), and morphine and naloxone in different groups. Passive avoidance memory was evaluated on day 7 after BDL by shuttle box test. Data were analyzed by PRISM software and ANOVA. Results: Naloxone (0.6 and 0.8 mg/kg), 30 min before the test, did not show significant changes in the memory of the cholestatic rats compared to the BDL group, whereas, morphine (4 and 6 mg/kg) showed significant increase in step-through latency (P

Objective: Upon hospitalization of a premature infant immediately after giving birth, mothers would experience high levels of anxiety. One of the essential non-pharmacological interventions to control the anxiety is massage. The purpose of this study was to investigate the effect of massage on the anxiety of mothers with preterm infants. Methods: In this experimental research, 140 samples were selected based on inclusion criteria using a convenience sampling method and then put in two groups of back massage and one control group. The tools for collecting the data were demographic questionnaire and Lehrer & Woolfolk's somatic, cognitive, and behavioral anxiety inventory. The data were analyzed using descriptive (Mean±SD) and inferential statistics tests (Chi-square, independent t-test, paired t-test, Fisher, and covariance analysis) by SPSS V. 13. Results: The mean scores of somatic, cognitive, and behavioral anxiety components showed significant differences before and after the intervention in the massage group (P

Objectives: Dietary n-3 polyunsaturated fatty acids have positive effects on the heart. The present study investigated the effects of pretreatment with fish oil (FO) and flaxseed oil (FLO) on the heart of the rat, which is associated with the isoprenaline (ISO)-induced myocardial injury. Materials and Methods: The study was conducted on 40 male Wistar rats which were included in control, ISO, FO + ISO, and FLO + ISO groups (each containing 10 rats). In ISO rats, acute myocardial ischemia was induced by ISO while in FO + ISO group, the rats were pretreated with FO orally for 4 weeks. Finally, rats in the FLO + ISO group received pretreatment with FO and flaxseed oil orally for 4 weeks. Eventually, the histopathological examinations of the cardiac tissues and serum activity of creatine kinase-MB (CK-MB) were assessed. Moreover, mitochondria were isolated to examine the mitochondrial swelling. Results: Based on the results, ISO administration significantly increased the serum CK-MB activity compared to the control group. In addition, severe muscular damage to the heart was observed in more than 70% of the rats in ISO group. However, a remarkable decrease in the intensity of heart tissue destruction, as well as the serum levels of CKMB was found in the FO + ISO group compared to the ISO group. Conversely, there was no significant decrease in the serum level of CKMB in FLO + ISO group compared to the ISO group. Conclusions: In general, pretreatment with FLO significantly suppressed the intensity of heart tissue destruction compared to the myocardial ischemic group. FO and FLO led to a decrease in CaCl2-induced swelling in the mitochondria. Therefore, FO and FLO result in protecting against ischemia/reperfusion injury through inhibiting the 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine.

Background: Diabetes is one of the most chronic and widespread diseases causing the damages to the male reproductive system. Nowadays, several studies have been performed to show the role of phenolic compounds in reducing the complications of diabetes. Carvacrol is a phenolic monoterpene which has been shown to have much therapeutic efficacy in various diseases. Methods: Thirty-two adult male Wistar rats (n = 8 in each group) were used in this experimental study. The induction of diabetes was performed using a single intraperitoneal (IP) injection of STZ (50 mg/kg). Rats were assigned into the following groups: control group, diabetic group, diabetic group daily fed with carvacrol at a dose of 75 mg/kg for 8 weeks, and the control group daily fed with carvacrol at a dose of 75 mg/kg for 8 weeks. Results: Treatment with carvacrol significantly improved the histological morphology of the testis, reduced the tissue activity of superoxide dismutase (SOD) and glutathione peroxidase (GPx) enzymes, and diminished the elevated levels of tissue malondialdehyde (MDA) (p < 0.05). Moreover, our results showed that carvacrol significantly decreased Bax and increased Bcl-2 at the levels of gene and protein expression. It also significantly (p

Objectives: Polyunsaturated fatty acids (PUFAs) are useful in reducing the deleterious effects of ischemia-reperfusion (IR). This study was designed to compare the impacts of treatment with flaxseed oil (FLO), rich in linoleic and alpha-linolenic acids, and fish oil containing long PUFAs, as well as eicosapentaenoic and docosahexaenoic acids (DHAs), on IR injury in the rat kidney. Materials and Methods: In this experimental study, 32 male Wistar rats were randomly divided into 4 groups (8 rats each) including Sham, IR, FLO, and fish oil (FO). Correspondingly, experimental groups were administered saline and flaxseed or FO at doses of 0.4 g/kg by gavage. After 4 weeks, the rats underwent right nephrectomy and 45-minute clamping of the left renal arteries followed by 24 hours reperfusion. Renal function was assessed by measuring the serum creatinine (Cr) and blood urea nitrogen (BUN) levels. The oxidative stress and serum aspartate aminotransferase (AST) activity were measured. Each kidney was sectioned into 2 equal parts. One part was used for pathological evaluations after hematoxylin-eosin staining and the other one was applied in assaying the malondialdehyde (MDA) level. Results: Serum Cr and BUN levels, AST activity, and tissue MDA content increased in the IR group. Both FO and FLO decreased tissue MDA levels (P < 0.05 vs. IR), but could not lead to a significant reduction in the levels of the renal markers. In addition, histological damages which were increased following the IR were markedly reduced by these 2 oils. Conclusions: Generally, FLO and FO may provide protection against IR-induced renal injury and oxidative stress. However, these effects were not significant between the 2 supplementations.

Objective: To evaluate the impact of Olea (O.) europaea extract on markers of oxidative stress and apoptosis of ovarian tissues in a rat model of torsion/detorsion-induced ovarian damage. Methods: A total of 28 Wistar female rats were randomly assigned into 4 groups, with 7 rats in each group. The sham group received a 2.5 cm longitudinal incision in the midline part of the abdomen which was then sutured with 5-0 nylon thread; the torsion/detorsion group underwent torsion induction for 3 h followed by reperfusion for 10 days; the torsion/detorsion+O. europaea group received 300 mg/kg hydro-alcoholic extract of O. europaea 30 min before detorsion, followed by reperfusion for 10 days; and the O. europaea group only received 300 mg/kg hydro-alcoholic extract of O. europaea for 10 days. After the treatment period, blood samples were taken; the levels of estrogen, glutathione peroxidase, superoxide dismutase, and malondialdehyde were assayed. The histological changes, as well as the rate of apoptosis in ovarian tissues, were also carried out by histomorphometric analysis at day 10 post-procedure. Results: Histological comparisons demonstrated a significant detrimental change in the torsion/ detorsion group as compared with other groups. The number of pre-antral and antral follicles and corpus luteum was significantly decreased in the torsion/detorsion group compared with the sham group, while treatment with O. europaea could enhance their numbers (P

BACKGROUND: Health-care providers, including physicians and nurses, are vital resources of the health-care system, and their health is essential to ensure safe care and to control outbreaks in the community. The aim of this study was to explore the experiences of physicians and nurses infected with COVID-19. MATERIALS AND METHODS: This descriptive exploratory qualitative study was conducted in 2020. To conduct this study, 19 participants (5 physicians and 14 nurses) were selected using purposive sampling. Data were collected using semi-structured interviews. Data analysis was performed using conventional content analysis. RESULTS: Eight main categories of “Fear and anxiety,” “Fighting against COVID-19,” “Feeling abandoned during home quarantine period,” “Denial of disease despite testing positive,” “Recovery: the second opportunity,” “Imposition of psychological burden after returning to work,” “Promotion of the health professional perception,” and “Promising supportive resources,” as well as 21 subcategories, were extracted from the participants' experiences. CONCLUSION: The experiences of physicians and nurses with COVID-19 revealed that their perception of the profession and providing care had changed. This experience has highlighted the focus and effort to promote patient-centered care and interprofessional collaboration among them.

Background There is some evidence indicating that Matricaria chamomile (MC) had protective effects on ischemia- reperfusion. In the present study, a rat model was used to investigate the effect of hydroalcoholic extract of MC on torsion/detorsion-induced testis tissue damage. Materials and Methods In this experimental study, 28 male Wistar rats were randomly divided into 4 groups as follows: G1, Sham operated; G2, testicular torsion/detorsion (T/D); G3, rats with testicular torsion/detorsion that received 300 mg/kg of MC extracts 30 minutes before detorsion (T/DMC); and G4, healthy rats that received 300 mg/kg of MC extracts (MC). Also, the reperfusion period was 24 hours. After blood sampling, the oxidative stress marker [e.g. superoxide dismutase (SOD) levels], blood levels of testosterone, and anti-oxidant enzyme levels [e.g. glutathione peroxidase (GPx)] were assessed by ELISA methods. Serum activity of malondialdehyde (MDA) was evaluated by spectrophotometry. Another assessment was carried out by histomorphometry, 24-hour post-procedure. The histological parameters investigated by Johnson’s scores (JS), also the seminiferous tubule diameter (STD) and the height of the germinal epithelium (HE) measured using the linear eyepiece grids using light microscopy. Results Histological features significantly differed between sham and the other groups. The levels of SOD, GPx, and testosterone hormone were significantly decreased in T/D group as compared to sham group, while these parameters increased in T/DMC group as compared to T/D group. During ischemia, the MDA levels increased; however, treatment with MC extract decreased the MDA levels in G3 and G4 groups. Conclusion Results of the present study demonstrated that MC can protect the testis tissue against torsion/detorsion- induced damages by suppressing superoxide production.

BACKGROUND: Breathing and living on mechanical ventilation develops a different feeling in patients. Most of such feelings and experiences are not pleasant and can lead to psychiatric disorders in the patients after they are detached from the ventilator. The aim of this study is to explore the psychological experiences of patients under mechanical ventilation. METHODS: This qualitative study was conducted according to an interpretive epistemological approach in 2016. Fifteen participants were selected according to purposive sampling. Data were drawn from the transcripts of in-depth, semi-structured interview that were not discontinued until data saturation was ensured. The participants were asked to share what they experienced when they were under mechanical ventilation and intubation. Data analysis was conducted according to Diekelmann method. RESULTS: Altogether, 2 themes, 7 subthemes, and 27 sub-subthemes were drawn from the data. Two themes were dread (a horrible experience) and hope (an inspiring experience). Dread consisted of anxiety, hopelessness, and dependency. Hope consisted of spiritual connection as the only possible effort, the presence of health team the source of comfort, the family looking forward, and overcoming the illness (a step to life). CONCLUSION: The psychological experiences of patients under mechanical ventilation are specific, and nurses can play an important role in decreasing tension and increasing hope among them through gaining knowledge about their experiences.

The present study was designed to investigate the effect of early and late administration of phenylephrine during ischemia against regional ischemia-reperfusion injuries in an isolated rat heart model. All animals were randomly divided into experimental groups: (I) IR (Ischemic/ reperfusion): the hearts underwent 35 min of regional ischemia followed by 60 min of reperfusion; (II) 5HD-IR-0: the hearts were perfused for 5 min with 5HD (5-hydroxydecanoate, specific mKATP channel blocker, 100 µM) at the onset of regional ischemia; (III) 5HD-IR-20: the hearts were perfused for 5 min with 5HD 20 min after regional ischemia; (IV) PE-IR-10: the hearts were perfused for 5 min with phenylephrine 10 min after regional ischemia; (V) PE-IR-30: the hearts were perfused for 5 min with phenylephrine (100 µM) 30 min after regional ischemia; (VI) PE-5HD-IR-10 group: the hearts were perfused for 5 min with 5HD at the onset of regional ischemia after which phenylephrine was administrated as in group IV; and (VII) PE-5HD-IR-30: the hearts were perfused for 5 min with 5HD 20 min after the ischemia and then phenylephrine was administrated as in group V. The hemodynamic parameters were recorded throughout the experiment. Ischemia-induced arrhythmias, myocardial infarct size (IS), creatin kinase-MB isoenzyme (CK-MB), plasma lactate dehydrogenase (LDH) activities, and coronary blood flow (CBF) were measured in all animals. Perfusion of phenylephrine 30 min after the regional ischemia curtailed the myocardial infarct size, reduced CK-MB, and improved cardiac function and CBF. Administration of 5HD 30 min after the ischemia abolished cardioprotective effects of phenylephrine in the late phase. These results suggest the involvement of mKATP in the mechanism of phenylephrine-induced late preconditioning.

Background and Objective: Effective communication is an essential characteristic of nursing care carried out as a necessity in education to empower patients. Therefore, this study aimed to determine Nurses' knowledge, attitude and practice about effective communication skills in Patient education. Material and Methods: This cross-sectional study was conducted on 275 nurses selected via stratified random sampling in teaching and therapeutic centers of Esfahan University of medical sciences, 2013.We collected the data by a research-made questionnaire related to knowledge and attitude, and a checklist to observe nurses' communication skills. To analyze the data , Central indices were calculated. Results: of 275 nurses , 86.7 % made a friendly atmosphere with their patients and 72.2% showed positive feedback, while their knowledge about communication components were 79.6 % . They (67.3%) were active listeners and they (96.7%) had close communication during patient education. Conclusion: given that nurses' communication skills are moderate, we recommend holding communication-skills workshops especially in patient education.

Background: Cancer is a broad group (over 270 types) of diseases. This disease, like other chronic diseases, occurs in all ages and ethnic groups, and is considered as a major health problem. Stress is one of the most important psychological factors influencing the occurrence of physical diseases, and can lead to severe anxiety, depression, and negative effects on health. It can also make individuals vulnerable to physical diseases, and in the long term, leads to death. This study was conducted to determine the effect of inoculation training on stress, anxiety, and depression in cancer patients. Materials and Methods: This study was conducted in 2013 as a clinical trial with convenient random sampling of patients from the chemotherapy clinic of Seyed Al-Shohada hospital of Isfahan. Forty patients with cancer who were eligible for the study were randomly assigned to either case or control group. The case and control groups had the same treatment plans, and the only difference was stress inoculation training administered in the case group, which was composed of eight 90-min sessions over 8 weeks. Data were collected using Depression, Anxiety, Stress Scales 42 (DASS-42) questionnaire and demographic questionnaire, and analyzed by analysis of covariance (ANCOVA) and t-test in SPSS. Results: The results showed that there was a significant difference between case and control groups in terms of stress, anxiety, and depression ( P < 0.001). Stress inoculation training reduced stress, anxiety, and depression in cancer patients. Conclusions: Stress inoculation training significantly reduced stress, anxiety, and depression. Therefore, teaching this skill and the strategies of coping with stress is recommended for these patients, in addition to medicational treatment.

Introduction: Self-efficacy has an important role in applying scientific and professional knowledge and skills. Teaching methods can develop different skills such as decision making capability. The aim of this study was to determine the effect of teaching method of lecture in comparison with lecture and problem based learning on nursing students self-efficacy in Najafabad Islamic Azad University during 2008-2009. Methods: In this quasi-experimental study, 44 nursing students who had been admitted to the university in 2006, were selected through random sampling method. Then, they were assigned in to two experiment and control groups, randomly. The data gathering tool was the Iranian edition of Generalized Self Efficacy questionnaire (GSE10). The data were analyzed by version 15 of SPSS software using mean, standard deviation and independent t-test and paired t-test. Results: The self-efficacy score increased significantly in both lecture (p

INTRODUCTION: For Muslim patients confronted with chronic diseases, spirituality is an important resource for coping. These patients expect the health team to take care of the spiritual aspects. This study aimed to explore the spiritual aspects of care for chronic Muslim patients. MATERIALS AND METHODS: This qualitative-descriptive exploratory study was conducted in Isfahan, Iran, on a purposive sample of 25 participants, including patients, caregivers, nurses, physicians, psychologists, social workers, and religious counselors. Data were collected through semi-structured interviews and analyzed through conventional content analysis. RESULTS: The spiritual aspects of care for chronic Muslim patients fell into four main themes. The first theme was religious aspect with the three subthemes of doing religious rituals, attention to religious values, and providing the possibility of performing religious practices. The second theme, i.e., pastoral aspect, consisted of three subthemes, namely giving consultation for finding the meaning of life/death, helping to achieve intellectual transcendence, and improve the patient's communication with herself/himself and others. The third theme was psychological aspect, the four subthemes of which included instilling calm to the patient, helping the patient to adapt, instilling hope, and empathy. Finally, the fourth theme was a supportive aspect and included the four subthemes of maintaining patient's basic needs, continuity of care at home, creating awareness, and acceptance and observance of patient's respect. CONCLUSION: Providing care based on the spiritual needs of chronic patients requires knowledge and skills that the health-care team need to provide through inter professional collaboration.