44 results on '"Mary Wu Chang"'
Search Results
2. Oral candidiasis and seborrheic dermatitis in an 8‐year‐old female with a heterozygous variant of the IL‐17RC gene
- Author
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Kathryn Bentivegna, Jonas A. Adalsteinsson, and Mary Wu Chang
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Pediatrics, Perinatology and Child Health ,Dermatology - Published
- 2023
3. Distinguishing annular pustular psoriasis from subcorneal pustular dermatosis—A diagnostic dilemma in a 10‐year‐old boy
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Joseph Masison, Jonas A. Adalsteinsson, and Mary Wu Chang
- Subjects
Pediatrics, Perinatology and Child Health ,Dermatology - Published
- 2023
4. The role of nutrition in acne vulgaris and hidradenitis suppurativa
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Aziz Khan and Mary Wu Chang
- Subjects
Adult ,Young Adult ,Adolescent ,Acne Vulgaris ,Quality of Life ,Humans ,Dermatology ,Diet ,Hidradenitis Suppurativa - Abstract
Acne vulgaris and hidradenitis suppurativa (HS) are chronic inflammatory, multifactorial skin disorders that often develop in adolescence and young adulthood. Both acne vulgaris and HS can cause significant morbidity and psychologic distress, with a negative effect on the quality of life. The relationship among diet, acne, and HS remains somewhat controversial; however, there is increasing evidence that high-glycemic diets and consumption of milk and dairy products promote acne. Studies suggest that weight loss through dietary interventions or bariatric surgery and brewer's yeast exclusion diets have the potential to ameliorate the signs of HS. We review the role of diet in the pathogenesis, prevention, and treatment of HS and acne vulgaris.
- Published
- 2022
5. Simultaneous occurrence of idiopathic trachyonychia in dizygotic twins
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Lorin A. Bibb and Mary Wu Chang
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medicine.medical_specialty ,Nail disorders ,integumentary system ,business.industry ,Longitudinal ridging ,Nails, Malformed ,Dermatology ,Dizygotic twins ,Chronic disorders ,Trachyonychia ,Nail Diseases ,medicine.anatomical_structure ,Nails ,Pediatrics, Perinatology and Child Health ,Nail (anatomy) ,medicine ,Twins, Dizygotic ,Humans ,Genetic Predisposition to Disease ,business - Abstract
Trachyonychia (or twenty-nail dystrophy) is an uncommon chronic disorder manifesting as thin, flattened, brittle nails with excessive longitudinal ridging and loss of luster creating a "sandpaper-like" texture that most commonly presents spontaneously in childhood as an isolated phenomenon; however, it has been historically associated with numerous dermatoses. Rarely, trachyonychia has been reported to occur in families, suggesting a potential hereditary predisposition. We report trachyonychia occurring simultaneously in dizygotic twins, further supporting a possible underlying genetic basis of this idiopathic nail disorder.
- Published
- 2021
6. Six Children With Allergic Contact Dermatitis to Methylisothiazolinone in Wet Wipes (Baby Wipes)
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Radhika Nakrani and Mary Wu Chang
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Male ,medicine.medical_specialty ,Diaper Dermatitis ,chemistry.chemical_compound ,Diaper rash ,Methylisothiazolinone ,medicine ,Humans ,Child ,Allergic contact dermatitis ,business.industry ,Wet wipe ,technology, industry, and agriculture ,Household Products ,Methylchloroisothiazolinone ,medicine.disease ,Dermatology ,Thiazoles ,chemistry ,Child, Preschool ,Dermatitis, Allergic Contact ,Pediatrics, Perinatology and Child Health ,Eczematous dermatitis ,Female ,business ,Contact dermatitis ,Disinfectants - Abstract
Methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) is a combination preservative used in personal care and household products and is a common cause of allergic contact dermatitis (ACD). Recently, MI alone, without MCI, has been increasingly used in consumer products in attempts to minimize allergic reactions. Wet wipes are extensively tested and traditionally believed to be innocuous. MI in wet wipes (“baby wipes”) has not been previously reported to cause ACD in children in the United States. Only 1 previous report of ACD in a child in Belgium has been recently reported. We report 6 children with chronic, perianal/buttock, and facial eczematous dermatitis, refractory to multiple topical and oral antibiotics and corticosteroids. All tested positive to MCI/MI on patch testing. None wore diapers. All patients had been using wet wipes containing MI (without MCI) to affected areas. Discontinuation of wipes resulted in rapid and complete resolution. This is the first report of pediatric ACD to MI in wet wipes in the United States, and the largest series to date. ACD to MI in wet wipes is frequently misdiagnosed as eczema, impetigo, or psoriasis. Wet wipes are increasingly marketed in personal care products for all ages, and MI exposure and sensitization will likely increase. Dermatitis of the perianal, buttock, facial, and hand areas with a history of wet wipe use should raise suspicion of ACD to MI and prompt appropriate patch testing. Rapid resolution occurs after the allergen exposure is eliminated. All isothiozolinones should be avoided in personal care and household products for these patients.
- Published
- 2014
7. Psoriasis in adults and children: Kids are not just little people
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Mary Wu Chang, Bruce Strober, and Elle H. de Moll
- Subjects
Adult ,medicine.medical_specialty ,Adolescent ,media_common.quotation_subject ,MEDLINE ,Dermatology ,Disease ,Administration, Cutaneous ,Ultraviolet therapy ,Diagnosis, Differential ,030207 dermatology & venereal diseases ,03 medical and health sciences ,Presentation ,Young Adult ,0302 clinical medicine ,Psoriasis ,medicine ,Humans ,030212 general & internal medicine ,Young adult ,Psychiatry ,Child ,media_common ,Metabolic Syndrome ,Biological Products ,business.industry ,Arthritis, Psoriatic ,Age Factors ,Infant, Newborn ,Infant ,medicine.disease ,Family medicine ,Child, Preschool ,Disease Progression ,Ultraviolet Therapy ,Dermatologic Agents ,business ,Psychosocial ,Immunosuppressive Agents ,Pediatric population - Abstract
Pediatric psoriasis is a common skin disorder. Although pediatric psoriasis has many similarities to adult psoriasis, there are differences in presentation, particularly in infants. In addition, a more limited therapeutic armamentarium exists for children due to different inherent risks. Nearly all therapies are unapproved in the pediatric population, with far fewer pre- and postmarketing studies having been conducted. Despite these challenges, appropriate treatment should never be denied to a young patient, as physical and psychosocial ramifications of psoriasis in the school age child and adolescent are significant. A partnership with the patient, caregivers, and primary care providers is necessary and rewarding in meeting the challenges of this chronic, incurable disease. We address the presentation, treatment options, and counseling necessary when treating psoriasis in the pediatric population.
- Published
- 2016
8. Acne: Kids are not just little people
- Author
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Diane Whitaker-Worth, Mary Wu Chang, and Syril Keena T. Que
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Adult ,Pediatrics ,medicine.medical_specialty ,Adolescent ,Dermatology ,Disease ,030207 dermatology & venereal diseases ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,030225 pediatrics ,Acne Vulgaris ,medicine ,Endocrine system ,Humans ,Dosing ,Young adult ,Child ,Isotretinoin ,Acne ,business.industry ,Age Factors ,Infant, Newborn ,Infant ,medicine.disease ,Hormones ,Surgery ,Anti-Bacterial Agents ,Child, Preschool ,Dermatologic Agents ,business ,medicine.drug ,Contraceptives, Oral - Abstract
Acne vulgaris is a common inflammatory disease of the pilosebaceous follicles that affects patients of all ages, from neonates to adults. We have compared and contrasted the clinical presentation of acne in neonates, infants, children, teenagers, and young adults and review the scenarios in which further systemic endocrine or hormonal tests are indicated. We also discuss age-dependent treatment considerations, including appropriate oral antimicrobial regimens and the proper dosing of isotretinoin in young children versus teenagers and adults.
- Published
- 2016
9. Pediatric Contact Dermatitis Registry Inaugural Case Data
- Author
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Keri Chaney, Nico Mousdicas, Cory A. Dunnick, Mary Wu Chang, Judith V. Williams, Douglas L. Powell, Rachel Frederickson, Michelle Draper, Aida Lugo-Somolinos, Antonella Tosti, Gary Kleiner, Jonathan H. Zippin, Sharon E. Jacob, Nina Botto, Tracy S. Estes, Leslie P. Lawley, Luz Fonacier, Janice L. Pelletier, Andrew Scheman, Brian C Machler, Jonathan I. Silverberg, Alina Goldenberg, Kalman L. Watsky, Leon H Kircik, Catalina Matiz, and Nanette B. Silverberg
- Subjects
Male ,medicine.medical_specialty ,Pediatrics ,Balsam of Peru ,Adolescent ,MEDLINE ,Dermatology ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Bacitracin ,Nickel ,Formaldehyde ,Epidemiology ,Health care ,medicine ,Immunology and Allergy ,Humans ,Registries ,Child ,Allergic contact dermatitis ,Retrospective Studies ,Balsams ,business.industry ,Infant, Newborn ,Patch test ,Infant ,Retrospective cohort study ,Neomycin ,Cobalt ,Allergens ,Patch Tests ,medicine.disease ,Propylene Glycol ,United States ,Perfume ,Betaine ,030228 respiratory system ,Child, Preschool ,Dermatitis, Allergic Contact ,Female ,Gold ,business ,Contact dermatitis - Abstract
Background Little is known about the epidemiology of allergic contact dermatitis (ACD) in US children. More widespread diagnostic confirmation through epicutaneous patch testing is needed. Objective The aim was to quantify patch test results from providers evaluating US children. Methods The study is a retrospective analysis of deidentified patch test results of children aged 18 years or younger, entered by participating providers in the Pediatric Contact Dermatitis Registry, during the first year of data collection (2015-2016). Results One thousand one hundred forty-two cases from 34 US states, entered by 84 providers, were analyzed. Sixty-five percent of cases had one or more positive patch test (PPT), with 48% of cases having 1 or more relevant positive patch test (RPPT). The most common PPT allergens were nickel (22%), fragrance mix I (11%), cobalt (9.1%), balsam of Peru (8.4%), neomycin (7.2%), propylene glycol (6.8%), cocamidopropyl betaine (6.4%), bacitracin (6.2%), formaldehyde (5.7%), and gold (5.7%). Conclusions This US database provides multidisciplinary information on pediatric ACD, rates of PPT, and relevant RPPT reactions, validating the high rates of pediatric ACD previously reported in the literature. The registry database is the largest comprehensive collection of US-only pediatric patch test cases on which future research can be built. Continued collaboration between patients, health care providers, manufacturers, and policy makers is needed to decrease the most common allergens in pediatric consumer products.
- Published
- 2016
10. Molecular diagnosis of a benign proliferative nodule developing in a congenital melanocytic nevus in a 3-month-old infant
- Author
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Mary Wu Chang, Jane M. Grant-Kels, Michael Murphy, Melinda Jen, and Hanspaul S. Makkar
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Male ,Pathology ,medicine.medical_specialty ,Skin Neoplasms ,Dermatology ,Congenital melanocytic nevus ,medicine ,Chromosomes, Human ,Humans ,Nevus ,skin and connective tissue diseases ,neoplasms ,Cell Proliferation ,Skin ,Chromosome Aberrations ,Nevus, Pigmented ,business.industry ,Melanoma ,Infant ,Nucleic Acid Hybridization ,Histology ,Nodule (medicine) ,Deep Penetrating Nevus ,Melanocytic nevus ,medicine.disease ,Immunohistochemistry ,Ki-67 Antigen ,Melanocytes ,medicine.symptom ,business ,Comparative genomic hybridization - Abstract
Small and intermediate congenital melanocytic nevi have a lifetime risk of developing melanoma estimated to range from 0% to 5%. Secondary benign melanocytic proliferations commonly arise in congenital melanocytic nevi; however, some are difficult to definitively distinguish from malignant melanoma based on clinical features and conventional histology. Herein, we describe the use of comparative genomic hybridization in supporting the diagnosis of a deep penetrating nevus developing within a congenital melanocytic nevus of a 3-month-old infant.
- Published
- 2008
11. Severe Varicella Caused by Varicella-Vaccine Strain in a Child With Significant T-Cell Dysfunction
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Anne A. Gershon, William Borkowsky, Mary Wu Chang, Philip LaRussa, Patrick Jean-Philippe, Sharon Steinberg, and Abigail Freedman
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Pediatrics ,medicine.medical_specialty ,Varicella vaccine ,T-Lymphocytes ,media_common.quotation_subject ,Chickenpox Vaccine ,T-cell dysfunction ,Chickenpox ,medicine ,Humans ,Girl ,Immunodeficiency ,media_common ,business.industry ,Immunologic Deficiency Syndromes ,Infant ,medicine.disease ,Rash ,Pneumonia ,Pediatrics, Perinatology and Child Health ,Immunology ,Female ,medicine.symptom ,business - Abstract
In March 1995, the US Food and Drug Administration approved a live attenuated varicella vaccine for use in healthy children 12 months to 12 years old. We report here an 18-month-old girl with cell-mediated immunodeficiency who developed a severe vaccine-associated rash and clinical evidence of vaccine-associated pneumonia 1 month after inadvertent receipt of varicella vaccine.
- Published
- 2007
12. Infantile granular parakeratosis: Recognition of two clinical patterns
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Narciss Mobini, Seth J. Orlow, Mary Wu Chang, David E. Cohen, Hideko Kamino, and Julie M Kaufmann
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Male ,Pathology ,medicine.medical_specialty ,Biopsy ,Dermatology ,Intertriginous ,Groin ,Diagnosis, Differential ,Retention hyperkeratosis ,medicine ,Humans ,Granular parakeratosis ,Idiopathic disorder ,Parakeratosis ,Skin ,business.industry ,Diapers, Infant ,Infant ,medicine.disease ,Dyskeratosis ,Diaper Rash ,Topical agents ,Female ,medicine.symptom ,business - Abstract
Granular parakeratosis is an acquired, idiopathic disorder of keratinization typified by retention hyperkeratosis. It usually occurs in women at intertriginous sites. There have been only 2 reports of infants with granular parakeratosis to our knowledge. We describe 3 additional infants with granular parakeratosis. We demonstrate that infantile granular parakeratosis exhibits 2 clinical patterns: bilateral linear plaques in the inguinal folds; and erythematous geometric plaques underlying pressure points from the diaper. A thick, flakelike scale is present in both forms and is characteristic. Diaper wearing appears to play an important role in the genesis of infantile granular parakeratosis but the mechanisms are unclear. Therapeutic responsiveness to topical agents is ambiguous, however, spontaneous clearance after months to 1 year appears to be the rule.
- Published
- 2004
13. Genetic association of cutaneous neonatal lupus with HLA class II and tumor necrosis factor ?: Implications for pathogenesis
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Steven R. Cohen, Lela A. Lee, Chelsea B. Backer, Mary Wu Chang, Jill P. Buyon, Robert R. Clancy, and Xiaoming Yin
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medicine.medical_specialty ,Discoid lupus erythematosus ,Immunology ,Subacute cutaneous lupus erythematosus ,Pathogenesis ,Rheumatology ,immune system diseases ,HLA-DQ Antigens ,Internal medicine ,Lupus Erythematosus, Cutaneous ,medicine ,Genetic predisposition ,HLA-DQ beta-Chains ,Humans ,Immunology and Allergy ,Pharmacology (medical) ,skin and connective tissue diseases ,Systemic lupus erythematosus ,Tumor Necrosis Factor-alpha ,business.industry ,Infant, Newborn ,HLA-DR Antigens ,medicine.disease ,Rash ,Heart Block ,Epidermis ,medicine.symptom ,business ,Anti-SSA/Ro autoantibodies - Abstract
Objective Cutaneous neonatal lupus resembles subacute cutaneous lupus erythematosus (SCLE), and photosensitivity is a common symptom. Tumor necrosis factor α (TNFα) release by ultraviolet light–exposed keratinocytes may be exaggerated in SCLE patients who have the haplotype TNFα −308A;DRB1*03. Accordingly, this study was undertaken to seek genetic and histologic evidence for a role of TNFα in the pathogenesis of cutaneous neonatal lupus. Methods DNA was isolated from 83 children (22 with rash, 35 with congenital heart block [CHB], 26 unaffected siblings) and 58 mothers from the Research Registry for Neonatal Lupus. Results The −308A allele (associated with higher TNFα production), HLA–DRQB1*02, and HLA–DRB1*03 were each present in the majority of children with rash (64%, 68%, and 64%, respectively). The frequency of all 3 6p alleles occurring together in 1 individual was greater in children with rash than in children who had either CHB or no manifestation of neonatal lupus (59% versus 30%; P = 0.02). This association with neonatal lupus rash was equivalent to published findings in a cohort of patients with SCLE, but significantly greater than the association in patients with discoid lupus erythematosus. Prominent TNFα staining in the epidermis was observed in lesional skin from 3 children with rash, but not in skin from a healthy neonate. Conclusion Taken together, the finding of a genetic predisposition to generate increased levels of TNFα following tissue injury and the histologic demonstration of TNFα in the target organ support the notion that this inflammatory cytokine plays a role in the pathogenesis of cutaneous neonatal lupus. Furthermore, the results of these studies provide evidence of a biologic link between neonatal lupus and the rash of SCLE.
- Published
- 2004
14. Updated Classification of Hemangiomas and Other Vascular Anomalies
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Mary Wu Chang
- Subjects
Male ,Pathology ,medicine.medical_specialty ,Monosaccharide Transport Proteins ,Cardiovascular Abnormalities ,Diagnosis, Differential ,Hemangioma ,medicine ,Humans ,cardiovascular diseases ,Granuloma, Pyogenic ,Confusion ,Glucose Transporter Type 1 ,Pyogenic granuloma ,business.industry ,Infant, Newborn ,Infant ,medicine.disease ,Immunohistochemistry ,Vascular Neoplasms ,eye diseases ,body regions ,Vascular Tumors ,Kaposiform Hemangioendothelioma ,Hemangioendothelioma ,Female ,Endothelium, Vascular ,sense organs ,Vascular pathology ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business - Abstract
Vascular anomalies comprise a widely heterogenous group of tumors and malformations. Great confusion has arisen because of the term hemangioma has been and is continued to be used to represent a multitude of vascular entities. This review presents the updated classification of vascular anomalies with the goal of clarifying the term hemangioma. In addition, newer clinical concepts in hemangiomas and other vascular tumors is presented. Hemangioma subtypes and hemangioma variants are also discussed, and a brief review of pyogenic granuloma and Kaposiform hemangioendothelioma is provided. Finally, the immunohistochemical marker GLUT1 is reviewed, a marker that heralds a new era in vascular anomalies research.
- Published
- 2003
15. Drug eruptions in children
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Mary Wu Chang and Helen T. Shin
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Drug ,medicine.medical_specialty ,Cutaneous eruptions ,business.industry ,media_common.quotation_subject ,Dermatology ,medicine.disease ,Drug eruption ,Surgery ,Pediatrics, Perinatology and Child Health ,Medicine ,Drug reaction ,business ,media_common - Abstract
Over 1000 medications are in common usage today. Approximately 700 of these are associated with a variety of cutaneous eruptions. The vast majority of cutaneous drug reactions in children are of 5 types: exanthems, fixed drug reactions, urticarial eruptions, serum sickness-like reactions, and photosensitive eruptions. Among healthy children, adverse drug reactions are generally uncommon and usually minor. Common, serious, and interesting cutaneous drug eruption patterns are discussed in this monograph, with an emphasis on practical information for dermatologists who care for pediatric patients. (Curr Probl Dermatol 2002;14:147-182)
- Published
- 2001
16. Topical tretinoin and 5-fluorouracil in the treatment of linear verrucous epidermal nevus
- Author
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Mary Wu Chang, Tor Shwayder, and Jane J. Kim
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Male ,Topical tretinoin ,Pathology ,medicine.medical_specialty ,Antimetabolites ,Hamartoma ,medicine.medical_treatment ,Tretinoin ,Dermatology ,Linear verrucous epidermal nevus ,Skin Diseases ,Keratolytic Agents ,medicine ,Humans ,Child ,skin and connective tissue diseases ,Verrucous Nevus ,Chemotherapy ,integumentary system ,business.industry ,medicine.disease ,Tretinoina ,Drug Combinations ,Fluorouracil ,Inflammatory linear verrucous epidermal nevus ,business ,medicine.drug - Abstract
Treatment of a linear verrucous epidermal nevus using topical 0.1% tretinoin cream and 5% 5-fluorouracil in a young patient is described. In 1994, successful topical therapy using this combination was described in the management of an inflammatory linear verrucous epidermal nevus. We report another case in which treatment of a noninflamed epidermal verrucous nevus with 0.1% tretinoin and 5% 5-fluorouracil resulted in significant improvement. An updated summary of the literature discussing management of epidermal nevi is presented.
- Published
- 2000
17. Ulcerated haemangioma of infancy: a retrospective review of 47 patients
- Author
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Mary Wu Chang, H.T. Shin, and Seth J. Orlow
- Subjects
Male ,Retrospective review ,Pediatrics ,medicine.medical_specialty ,Skin Neoplasms ,business.industry ,Treatment outcome ,Infant, Newborn ,New York ,MEDLINE ,Infant ,Retrospective cohort study ,Dermatology ,Treatment Outcome ,Skin Ulcer ,Humans ,Medicine ,Hemangioma ,business ,Retrospective Studies - Published
- 2007
18. Mucocutaneous manifestations of the hyper-IgM immunodeficiency syndrome
- Author
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Mary Wu Chang, Rowena Romero, Amy S. Paller, and Paul Scholl
- Subjects
Adult ,Male ,Hyper IgM syndrome ,medicine.medical_specialty ,Pathology ,X Chromosome ,Genetic Linkage ,Hyper-IgM Immunodeficiency Syndrome ,Mucocutaneous zone ,Dermatology ,Neutropenia ,Infections ,Skin Diseases ,Hypergammaglobulinemia ,Immunopathology ,medicine ,Humans ,Oral ulcers ,Child ,Oral Ulcer ,business.industry ,Gamma globulin ,Syndrome ,Oral ulcerations ,medicine.disease ,Immunoglobulin M ,Child, Preschool ,Dysgammaglobulinemia ,business - Abstract
Background: The recurrent pyogenic infections of patients with hyper-IgM syndrome are controlled by intravenous gamma globulin administration, but patients may suffer from early-onset oral ulcerations and warts. Objective: We have characterized the mucocutaneous manifestations associated with this condition to allow physicians to more readily identify it. Methods: Three male patients with the mucocutaneous manifestations of the hyper-IgM syndrome are described. In one, histopathologic examination of the oral mucosal lesion was performed. Results: Recurrent large, painful oral ulcerations can occur that are not necessarily associated with neutropenia nor do they respond to granulocyte colony-stimulating factor administration. Histopathologic examination of an ulcer showed a heavy infiltrate of mixed inflammatory cells. Warts tend to be widespread and resistant to traditional therapy. Conclusion: Physicians should consider this uncommon condition when examining a male patient with severe oral ulcers or recalcitrant widespread warts. (J Am Acad Dermatol 1998;38:191-6.)
- Published
- 1998
19. Confluent and Reticulated Papillomatosis Associated with Tinea Versicolor in Three Siblings
- Author
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Mary Wu Chang, Jennifer A. Stein, and Helen T. Shin
- Subjects
Male ,medicine.medical_specialty ,Pathology ,Antifungal Agents ,Skin Neoplasms ,Adolescent ,Papilloma ,business.industry ,Siblings ,Minocycline ,Dermatology ,medicine.disease ,Tinea versicolor ,Anti-Bacterial Agents ,Tinea Versicolor ,Pediatrics, Perinatology and Child Health ,medicine ,Confluent and reticulated papillomatosis ,Humans ,Female ,Selenium Compounds ,business ,Pigmentation disorder ,Mycosis - Abstract
We describe three teenage siblings with confluent and reticulated papillomatosis, all presenting during a 6-month period. Two of the three patients had confirmed tinea versicolor, with positive potassium hydroxide scrapings, in association with this entity. This is the largest series of siblings with confluent and reticulated papillomatosis, and the only report describing family members having both confluent and reticulated papillomatosis and tinea versicolor. This report lends further evidence to the hypothesis that confluent and reticulated papillomatosis may be etiologically linked to tinea versicolor, and also suggests a genetic predisposition for it.
- Published
- 2005
20. Hidradenitis Suppurativa
- Author
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Melinda Jen and Mary Wu Chang
- Published
- 2013
21. Pityriasis Rubra Pilaris
- Author
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Mary Wu Chang and Melinda Jen
- Subjects
medicine.medical_specialty ,Erythema ,business.industry ,Psoriasis ,Medicine ,Ectropion ,Erythroderma ,Pityriasis rubra pilaris ,medicine.symptom ,business ,Keratoderma ,medicine.disease ,Dermatology - Published
- 2011
22. Congenital Self‐Healing Reticulohistiocytosis with Eye Involvement
- Author
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Hideko Kamino, Mary Wu Chang, Mark A. Steele, and Andrea L. Zaenglein
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Pathology ,medicine.medical_specialty ,Eye Diseases ,Histiocytosis, Non-Langerhans-Cell ,Eye disease ,Remission, Spontaneous ,Spontaneous remission ,Dermatology ,Disease ,Antigens, CD1 ,Diagnosis, Differential ,Langerhans cell histiocytosis ,medicine ,Humans ,Reticulohistiocytosis ,Skin ,business.industry ,Eye involvement ,S100 Proteins ,Infant, Newborn ,medicine.disease ,Immunohistochemistry ,Congenital self-healing reticulohistiocytosis ,Pediatrics, Perinatology and Child Health ,Female ,Differential diagnosis ,business - Abstract
Congenital self-healing reticulohistiocytosis (CSHR) represents the benign end of the spectrum of Langerhans cell histiocytoses, with spontaneous resolution of lesions within the first year of life. However, involvement of organ systems other than the skin has been described occasionally and recurrence of disease at sites distant from the skin has been documented. We report a case of CSHR with eye involvement that spontaneously resolved concurrent with resolution of skin lesions. Because multiple organ systems can be involved and recurrences are possible, long-term follow-up of these patients is indicated.
- Published
- 2001
23. This issue: skin emergencies
- Author
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Mary Wu Chang
- Subjects
medicine.medical_specialty ,business.industry ,MEDLINE ,Dermatology ,Skin Diseases ,Pediatrics, Perinatology and Child Health ,medicine ,Humans ,Clinical Competence ,Clinical competence ,Emergencies ,Periodicals as Topic ,Intensive care medicine ,business ,Child - Published
- 2010
24. Eczema herpeticum and eczema vaccinatum in children
- Author
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Mary Wu Chang and Melinda Jen
- Subjects
medicine.medical_specialty ,business.industry ,MEDLINE ,Immunoglobulins ,Kaposi Varicelliform Eruption ,medicine.disease ,Eczema vaccinatum ,Dermatology ,Antiviral Agents ,Dermatitis, Atopic ,Risk Factors ,Pediatrics, Perinatology and Child Health ,Eczema herpeticum ,Medicine ,Humans ,Smallpox vaccine ,business ,Child ,Smallpox Vaccine ,Smallpox - Published
- 2010
25. Contributors
- Author
-
David Adams, Sherri L. Adams, Chhavi Agarwal, Elizabeth R. Alpern, Armand H. Matheny Antommaria, Megan H. Bair-Merritt, Lourival Baptista-Neto, Jill Baren, Carl R. Baum, Eric D. Baum, Pamela J. Beasley, Suzanne Beno, Laurie A. Bernard, Stacey E. Bernstein, Chad K. Brands, Laura K. Brennan, Marisa B. Brett-Fleegler, Manish J. Butte, Julie Story Byerley, Diane P. Calello, Deirdre Caplin, Rebecca G. Carlisle, Douglas W. Carlson, Jean Marie Carroll, Mary Wu Chang, Grace M. Cheng, Aaron S. Chidekel, Denesh K. Chitkara, Bill Chiu, Christine S. Cho, Jeanne S. Chow, Bartley G. Cilento, Susan E. Coffin, Bernard A. Cohen, Kristina A. Cole, Patrick H. Conway, Maura Cooper, Timothy Cornell, Kate M. Cronan, Catherine Cross, Bari B. Cunningham, Melody J. Cunningham, Jennifer A. Daru, Ian J. Davis, Matthew A. Deardorff, Barbara Degar, Michael DelVecchio, David Ray DeMaso, Marissa de Ungria, Stephanie B. Dewar, Craig C. DeWolfe, Martha Dimmers, James G.H. Dinulos, Ed Donovan, Kenneth J. Dooley, Emmanuel Doyne, Christine N. Duncan, Marie Egan, Lawrence F. Eichenfield, Moussa El-hallak, Scott A. Elisofon, Stephen C. Eppes, Michele Burns Ewald, Mirna M. Farah, Chris Feudtner, Andrew M. Fine, Susan Hetzel Frangiskakis, Gary Frank, Eric Frehm, Nicole R. Frei, Ilona J. Frieden, Eron Y. Friedlaender, Jeremy Friedman, Robert Hugh Fryer, David R. Fulton, Paul J. Galardy, Mirabai Galashan, Mary Pat Gallagher, Beth D. Gamulka, Rupali Gandhi, Mary B. Garza, Maria C. Garzon, Robert L. Geggel, Michael H. Gewitz, Timothy Gibson, Amy E. Gilliam, Katherine B. Ginnis, Amy Goldberg, Anna M. Golja, Melissa J. Gregory, April A. Harper, Mary Catherine Harris, Natalie Hayes, Matthew M. Heeney, Diana M. Heinzman, Meredith Lee Heltzer, Keith D. Herzog, Malinda Ann Hill, Jessica L. Hills, Alejandro Hoberman, K. Sarah Hoehn, Amber M. Hoffman, Robert J. Hoffman, Amy P. Holst, Charles J. Homer, Paul J. Honig, Patricia M. Hopkins, Mark D. Hormann, B. David Horn, Michael S. Isakoff, Katherine A. Janeway, Katherine Ahn Jin, Maureen M. Jonas, Tammy Kang, Krista Keilty, Ron Keren, Anupam Kharbanda, Marin Kiesau, Caroline C. Kim, Jason Y. Kim, Juliann Lipps Kim, Nicola Klein, Paul K. Kleinman, Joel B. Korin, Uma Kotagal, Lisa K. Kresnicka, Rana N. Kronfol, Cynthia L. Kuelbs, Subra Kugathasan, Amethyst C. Kurbegov, Christopher P. Landrigan, Miriam Laufer, Christine Lauren, Daniel J. Lebovitz, Natasha Leibel, Lucinda P. Leung, Leonard J. Levine, Jason A. Levy, Phyllis A. Lewis, Marilyn G. Liang, Daniel J. Licht, Carolyn M. Long, Jeffrey P. Louie, Barry A. Love, Patricia V. Lowery, Ian B. MacLusky, Katarzyna Madejczyk, Mary Beth Madonna, Sanjay Mahant, Paul E. Manicone, Jennifer Maniscalco, Keith Mann, Rebekah Mannix, Jonathan M. Mansbach, Peter Mattei, Oscar H. Mayer, Sarah C. McBride, Kevin D. McBryde, Michele R. McKee, William McNett, Sanford M. Melzer, Talene A. Metjian, Denise W. Metry, Stephen E. Muething, Emily E. Milliken, Laura J. Mirkinson, Manoj K. Mittal, Angela C. Mix, Debra Monzack, Kimberly D. Morel, Douglas E. Moses, Eugene M. Mowad, Elizabeth A. Mullen, John B. Mulliken, Sharon Muret-Wagstaff, Nancy Murphy, Frances M. Nadel, Joshua Nagler, James A. Nard, Mark I. Neuman, Jason G. Newland, Alice W. Newton, Peter F. Nichol, Lise E. Nigrovic, Richard J. Noel, Sharon E. Oberfield, Maureen M. O'Brien, Karen J. O'Connell, Kevin C. Osterhoudt, Mary Ottolini, Raj Padman, Horacio M. Padua, Alka Patel, Susmita Pati, Jack M. Percelay, Jeannette M. Perez-Rossello, Kieran J. Phelan, Annapurna Poduri, J. Rainer Poley, Jill C. Posner, Sampath Prahalad, Howard B. Pride, Daniel Rauch, David J. Rawat, Scott Reeves, Daniel H. Reirden, Brandie J. Roberts, Jack Rodgers, José R. Romero, Paul Rosen, David M. Rubin, Esther Maria Sampayo, Lisa Samson-Fang, Gina Santucci, Julie V. Schaffer, Karen E. Schetzina, Sandra Schwab, Donald F. Schwarz, Jordan Scott, Steven M. Selbst, Kara N. Shah, Samir S. Shah, Nader Shaikh, Michael W. Shannon, Adhi N. Sharma, George K. Siberry, Karen Smith, Michael J. Smith, Michael J.G. Somers, Neal Sondheimer, Steven J. Spalding, Philip R. Spandorfer, Jonathan M. Spergel, Jeffrey L. Sperring, David A. Spiegel, Rajendu Srivastava, Keith H. St. John, Michael C. Stephens, Christopher C. Stewart, Bryan L. Stone, Erin R. Stucky, Eric R. Sundel, Robert Sundel, Suzanne Swanson, Lesli Taylor, E. Douglas Thompson, Avram Z. Traum, Harsh K. Trivedi, Bryan D. Upham, Andrea M. Vandeven, Brigid L. Vaughan, Charles P. Venditti, Venus M. Villalva, Robert N. Vincent, Samuel Volchenboum, Michael T. Vossmeyer, Robert M. Wachter, Daniel J. Weiner, Michael Weinstein, Elizabeth A. Wharff, Stephen D. Wilson, Jerry A. Winkelstein, Heidi Wolf, George A. Woodward, Albert C. Yan, Elaine H. Zackai, Andrea L. Zaenglein, Theoklis E. Zaoutis, and David Zipes
- Published
- 2007
26. Ecthyma Gangrenosum
- Author
-
Mary Wu Chang and Julie V. Schaffer
- Subjects
Ecthyma gangrenosum ,medicine.medical_specialty ,business.industry ,Medicine ,business ,medicine.disease ,Dermatology - Published
- 2007
27. Pigmented plexiform neurofibroma: Distinction from a large congenital melanocytic nevus
- Author
-
Olympia I Kovich, Seth J. Orlow, Mary Wu Chang, Hideko Kamino, and Julie V. Schaffer
- Subjects
Neurofibroma, Plexiform ,Pathology ,medicine.medical_specialty ,Nevus, Pigmented ,Neurofibromatosis 1 ,business.industry ,Papillary dermis ,Infant ,Dermatology ,Melanocytic nevus ,medicine.disease ,Hyperpigmentation ,Diagnosis, Differential ,Plexiform neurofibroma ,Congenital melanocytic nevus ,medicine ,Nevus ,Neurofibroma ,Humans ,Female ,sense organs ,medicine.symptom ,business ,Dermoepidermal junction - Abstract
The substantial clinical and histologic overlap between neurotized congenital melanocytic nevi and the subset of plexiform neurofibromas with hyperpigmentation and hypertrichosis of the overlying skin (pigmented neurofibroma) has led to considerable confusion in the literature. A dark-brown, hypertrichotic plaque covered much of the right lower aspect of the trunk of a 1-year-old girl with a diffuse and plexiform neurofibroma in the same area, numerous cafe-au-lait macules, and intertriginous freckling. The latter findings were diagnostic of neurofibromatosis-1, which was further supported by the presence of unidentified bright objects on magnetic resonance imaging of the brain. Histologic examination of the hyperpigmented plaque revealed melanocytic hyperplasia at the dermoepidermal junction and a proliferation of rounded, pigmented melanocytes dispersed individually and in occasional small nests in the papillary dermis and scattered within underlying neurofibromatous tissue. Immunohistochemical staining with A103 (Melan-A/MART-1) and PNL2 confirmed the melanocytic differentiation of the pigmented cells, whereas glial fibrillary acidic protein and Leu-7 were detected only within plexiform areas and slender neuroid spindle cells. This case draws attention to the pigmented neurofibroma as a distinct clinicopathologic entity resulting from proliferation of melanocytes and neurosustentacular cells in the setting of neurofibromatosis-1.
- Published
- 2006
28. Iododerma after computed tomographic scan with intravenous radiopaque contrast media
- Author
-
John E. Miner, Mary Wu Chang, Ali Moiin, and Ken Hashimoto
- Subjects
Skin Diseases, Vesiculobullous ,business.industry ,media_common.quotation_subject ,Contrast Media ,Dermatology ,medicine.disease ,Iododerma ,Computed tomographic ,Injections, Intravenous ,medicine ,Humans ,Contrast (vision) ,Female ,Drug Eruptions ,Tomography, X-Ray Computed ,Complication ,business ,Nuclear medicine ,Aged ,Diatrizoate Meglumine ,Iodine ,media_common - Published
- 1997
29. Infantile systemic hyalinosis
- Author
-
Seth J. Orlow, Mary Wu Chang, Helen T. Shin, George E. Hoganson, Amy S. Paller, and Judith P. Willner
- Subjects
Male ,medicine.medical_specialty ,Hyalin ,Contracture ,Infantile systemic hyalinosis ,Dermatology ,Diagnosis, Differential ,Medicine ,Humans ,Joint Contracture ,Thickened skin ,business.industry ,Collagen Diseases ,Infant, Newborn ,Infant ,medicine.disease ,Perianal region ,Hand ,Surgery ,Failure to Thrive ,Diarrhea ,Lower Extremity ,Frequent infections ,Fatal disease ,Buttocks ,Female ,medicine.symptom ,business ,Pigmentation Disorders - Abstract
Infantile systemic hyaloinosis is a rare, progressive, and fatal disease that is inherited in an autosomal recessive fashion. We describe 2 patients in whom thickened skin; small nodules of the perianal region, face, and neck; joint contractures; growth failure; diarrhea; and frequent infections developed within the first few weeks of life. Both patients died before 2 years of age.
- Published
- 2004
30. Congenital primary cutaneous rhabdomyosarcoma in a neonate
- Author
-
T. Hideko Kamino, Alexandra R. Brecher, Miguel Reyes-Múgica, and Mary Wu Chang
- Subjects
Male ,Chemotherapy ,Pathology ,medicine.medical_specialty ,Skin Neoplasms ,business.industry ,medicine.medical_treatment ,Infant, Newborn ,Dermatology ,medicine.disease ,Malignancy ,Radiation therapy ,Pediatrics, Perinatology and Child Health ,Alveolar rhabdomyosarcoma ,Medicine ,Immunohistochemistry ,Humans ,Desmin ,Sarcoma ,business ,Rhabdomyosarcoma ,Rhabdomyosarcoma, Alveolar - Abstract
We report a case of congenital primary cutaneous rhabdomyosarcoma, solid alveolar type, presenting as a solitary skin lesion on the right upper lip of a 2-week-old infant boy. Rhabdomyosarcoma originates from the embryonic mesenchyme precursor of striated muscle. Histologically it belongs to the group of "small round cell tumors." Its myogenic origin is ascertained by immunohistochemical studies positive for myogenin, muscle-specific actin, desmin, and myoglobin. Malignancy in the neonatal period is uncommon and the clinical management presents considerable challenges. Congenital alveolar rhabdomyosarcoma is a highly malignant tumor with no record of long-term survivors. Treatment options include chemotherapy, excision, and radiotherapy. This infant's tumor was responsive to chemotherapy and surgery and he was free of disease at the 6-month follow-up.
- Published
- 2003
31. What syndrome is this? Nail-patella syndrome
- Author
-
Deidre, Buddin, Cynthia, Loomis, Tor, Shwayder, and Mary Wu, Chang
- Subjects
Radiography ,Nail-Patella Syndrome ,Humans ,Female ,Child - Published
- 2002
32. Fever and rash in a 3-year-old girl: Rocky Mountain spotted fever
- Author
-
Julie M, Kaufmann, Andrea L, Zaenglein, Aditya, Kaul, and Mary Wu, Chang
- Subjects
Treatment Outcome ,Dose-Response Relationship, Drug ,Fever ,Child, Preschool ,Doxycycline ,Humans ,Female ,Exanthema ,Risk Assessment ,Rocky Mountain Spotted Fever ,Severity of Illness Index ,Drug Administration Schedule ,Follow-Up Studies - Abstract
Initial symptoms of Rocky Mountain spotted fever (RMSF), a tick-borne illness caused by Rickettsia rickettsii, are nonspecific and include headache, gastrointestinal disturbances, malaise, and myalgias, followed by fever and rash. The classic triad of fever, rash, and history of tick exposure is uncommon at presentation. Clinical manifestations of RMSF range from virtually asymptomatic to severe. Because of the potentially fatal outcome of RMSF, presumptive clinical diagnosis and empiric antimicrobial therapy can be critical. We present the case of a 3-year-old girl from New York State who presented with fever and rash.
- Published
- 2002
33. Extensive Riga-Fede disease of the lip and tongue
- Author
-
Andrea L. Zaenglein, Felicia B. Axelrod, Mary Wu Chang, Shane A Meehan, and Seth J. Orlow
- Subjects
Male ,Pathology ,medicine.medical_specialty ,Pain Insensitivity, Congenital ,Diagnostico diferencial ,Dermatology ,Disease ,Tongue ,medicine ,Humans ,Oral Ulcer ,business.industry ,Infant ,Riga–Fede disease ,Early infancy ,medicine.disease ,Lip ,stomatognathic diseases ,medicine.anatomical_structure ,Autonomic Nervous System Diseases ,Histopathology ,business ,Complication ,Autonomic neuropathy ,Tooth - Abstract
Riga-Fede disease presents in early infancy and is characterized by firm, verrucous plaques arising on the oral mucosal surfaces. These histologically benign lesions occur as a result of repetitive trauma of the oral mucosal surfaces by the teeth. Early recognition of this entity is important, because it may be the presenting sign of an underlying neurologic disorder. We report the case of a 10-month-old boy with extensive Riga-Fede disease involving the lip and tongue that prompted a diagnosis of congenital autonomic dysfunction with universal pain loss.
- Published
- 2002
34. Cutaneous anthrax associated with microangiopathic hemolytic anemia and coagulopathy in a 7-month-old infant
- Author
-
Martin J. Blaser, Robert G. Schacht, Michael Traister, Abigail Freedman, Jane Guttenberg, Guillermo I. Perez-Perez, William Borkowsky, Mary Wu Chang, Herb Lazarus, Olubunmi Afonja, and Farzad Mostashari
- Subjects
Hemolytic anemia ,Male ,medicine.medical_specialty ,Anemia, Hemolytic ,Anemia ,complex mixtures ,Anthrax ,Diagnosis, Differential ,Spider Bites ,Coagulopathy ,medicine ,Humans ,Spores, Bacterial ,Vascular disease ,business.industry ,Soft Tissue Infections ,fungi ,Microangiopathy ,Infant ,General Medicine ,Environmental exposure ,Microangiopathic hemolytic anemia ,Environmental Exposure ,Skin Diseases, Bacterial ,Disseminated Intravascular Coagulation ,medicine.disease ,Bone Diseases, Infectious ,Dermatology ,Bioterrorism ,Thrombocytopenia ,Bacillus anthracis ,Immunology ,New York City ,Hyponatremia ,business - Abstract
A 7-month-old infant with cutaneous anthrax developed severe systemic ill- ness despite early treatment with antibiotics. The infant displayed severe microangiopathic hemolytic anemia with renal involvement, coagulopathy, and hyponatremia. These findings are unusual with cutaneous anthrax, but have been described in illness resulting from spider toxin and may delay cor- rect diagnosis. The systemic manisfestations of the disease persisted for nearly a month despite corticosteroid therapy, but resolved.
- Published
- 2002
35. Cantharidin revisited: a blistering defense of an ancient medicine
- Author
-
Mary Wu Chang, Tor Shwayder, and Lisa Moed
- Subjects
medicine.medical_specialty ,Order Coleoptera ,Dermatology ,Skin Diseases ,Ancient medicine ,Food and drug administration ,chemistry.chemical_compound ,medicine ,Blistering eruption ,Animals ,Humans ,Drug Approval ,Folk medicine ,Cantharidin ,business.industry ,United States Food and Drug Administration ,General Medicine ,Cantharidin poisoning ,United States ,Surgery ,Coleoptera ,Cantharidine ,chemistry ,Irritants ,Medicine, Traditional ,business - Abstract
Cantharidin, a vesicant produced by beetles in the order Coleoptera, has a long history in both folk and traditional medicine. In dermatology, topical cantharidin has long been used to treat warts and molluscum. In 1962, cantharidin lost Food and Drug Administration (FDA) approval owing to the failure of its manufacturers to submit data attesting to cantharidin's efficacy. However, it is expected that the FDA will soon include cantharidin on its "Bulk Substances List," which would permit physicians or pharmacists to compound cantharidin to be used in the office for individual patients. A comprehensive discussion of the origins, folk uses, current FDA status, current dermatologic uses, and effects of cantharidin poisoning has been compiled herein. No cases of systemic intoxication or scarring have been reported with the proper use of cantharidin by a physician. Cantharidin is a safe and valuable medication and should be readded to the dermatologic therapeutic armamentarium.
- Published
- 2001
36. Trichorhinophalangeal Syndrome, Type II (Langer-Giedion Syndrome)
- Author
-
Helen T. Shin and Mary Wu Chang
- Subjects
business.industry ,Hearing loss ,Dermatology ,General Medicine ,Anatomy ,medicine.disease ,Penetrance ,Langer–Giedion syndrome ,Trichorhinophalangeal Syndrome Type II ,Trichorhinophalangeal syndrome ,Medicine ,Sparse hair ,Skeletal abnormalities ,medicine.symptom ,business ,Index case - Abstract
Trichorhinophalangeal syndrome (TRPS) is characterized by its unique facial features and skeletal abnormalities. A bulbous, pear-shaped nose, elongated philtrum, sparse hair, cone-shaped epiphyses and mild growth retardation are found in both type I (TRPSI) and type II (TRPSII). TRPSII can be distinguished from TRPSI when multiple exostoses or redundant skin are present. While TRPSI is inherited in an autosomal dominant fashion, most cases of TRPSII are sporadic although there are a few cases which are familial. The following is a case report of TRPSII with incomplete penetrance in the index case and exostoses and growth retardation in the patient's two siblings.
- Published
- 2001
37. Purpura fulminans caused by group A beta-hemolytic Streptococcus sepsis
- Author
-
Mary Wu Chang, Margaret Karpatkin, Selim Corbacioglu, Kavita M. Dhodapkar, and Donna DiMichele
- Subjects
Male ,medicine.medical_specialty ,IgA Vasculitis ,Streptococcus pyogenes ,Thrombophilia ,Sepsis ,Streptococcal Infections ,Scrotum ,Medicine ,Humans ,Gangrene ,business.industry ,Infant ,medicine.disease ,Thrombosis ,Surgery ,body regions ,Purpura ,medicine.anatomical_structure ,Anesthesia ,Child, Preschool ,Pediatrics, Perinatology and Child Health ,Fresh frozen plasma ,medicine.symptom ,business ,Purpura fulminans - Abstract
mL/kg/h). A second dose of t-PA was administered 3 days later, in an attempt to salvage impending digit loss. Thrombolytic therapy was well tolerated with the exception of bleeding at the site of the intravenous line and mild hematuria. By day 8 of hospitalization, his transfusional requirements ceased, and protein C levels had normalized. Heparin therapy was discontinued 2 days later. There was a significant improvement in his skin lesions and areas of impending gangrene, including his scrotum (Figure, B). However, all of his toes and 7 fingers were autoinfarcted. At discharge, 12 weeks after admission, he was neurologically intact and developmentally appropriate for age. His coagulation and hematologic measurements and renal function were normal. Thrombophilia workup of both parents for inherited predisposition to thrombosis was negative.
- Published
- 2000
38. Update on juvenile xanthogranuloma: unusual cutaneous and systemic variants
- Author
-
Mary Wu Chang
- Subjects
Nosology ,Pathology ,medicine.medical_specialty ,business.industry ,Juvenile xanthogranuloma ,Cutaneous nodules ,Dermatology ,medicine.disease ,Immunohistochemistry ,Skin Diseases ,Diagnosis, Differential ,Medicine ,Humans ,Surgery ,business ,Xanthogranuloma, Juvenile ,Organ system - Abstract
Juvenile xanthogranuloma (JXG) is a well-recognized benign disorder of infancy and early childhood characterized by yellowish cutaneous nodules that spontaneously regress over months to years. In the vast majority of children, JXG is limited to the skin and requires no treatment. Over the past two decades, unusual cutaneous and systemic forms of JXG have been increasingly reported. JXGs have been discovered, usually unexpectedly, in every organ system of the body. Correct diagnosis is crucial to prevent unnecessary invasive diagnostic and therapeutic procedures. Unusual clinical and histological variants of JXG often require immunohistochemical studies and/or electron microscopy to establish the diagnosis. Nonlipidized, giant, intramuscular, subcutaneous, and clustered JXG are but some of the variants that are discussed in this article. The immunohistochemistry of JXG, current nosology, and hypotheses regarding the origins of JXG are also reviewed.
- Published
- 1999
39. Atypical erythema toxicum neonatorum of delayed onset in a term infant
- Author
-
Seth J. Orlow, S. Brian Jiang, and Mary Wu Chang
- Subjects
Male ,Pathology ,medicine.medical_specialty ,Time Factors ,Erythema ,business.industry ,Neutrophils ,Delayed onset ,Infant, Newborn ,Diagnostic test ,Pustular Eruption ,Dermatology ,medicine.disease ,Eosinophils ,medicine.anatomical_structure ,Term Infant ,White blood cell ,Pediatrics, Perinatology and Child Health ,Erythema toxicum neonatorum ,medicine ,Humans ,medicine.symptom ,business - Abstract
We describe a 10-day-old term infant who presented to the emergency room with an acute pustular eruption. Laboratory tests and clinical outcome confirmed the diagnosis of erythema toxicum neonatorum. A full septic workup was performed and all cultures were negative. Wright-stained smear of pustular contents showed a predominance of neutrophils with 10% eosinophils. The white blood cell count was 19,000/mm3 with 10% eosinophils. The eruption resolved spontaneously at 15 days of age leaving no sequelae. This is the first fully documented case of erythema toxicum in a term infant occurring as late as 10 days of age. When erythema toxicum presents in an atypical fashion, diagnostic tests are important to exclude other causes of pustular dermatoses of the neonate.
- Published
- 1999
40. Erythema induratum of Bazin in an infant
- Author
-
Robert Lawrence, Mary Wu Chang, and Seth J. Orlow
- Subjects
Male ,Pathology ,medicine.medical_specialty ,Erythema induratum ,Tuberculosis ,Vascular disease ,business.industry ,Infant ,Erythema Induratum ,medicine.disease ,Nodular vasculitis ,medicine.anatomical_structure ,Pediatrics, Perinatology and Child Health ,Tuberculide ,medicine ,Etiology ,Humans ,business ,Skin pathology ,Tuberculosis, Pulmonary ,Subcutaneous tissue ,Skin - Published
- 1999
41. Sudoriferous acrosyringeal acantholytic disease. A subset of Grover's disease
- Author
-
Joji Tada, Mary Wu Chang, Ken Hashimoto, and Ali Moiin
- Subjects
Male ,Pathology ,medicine.medical_specialty ,Histology ,Paraneoplastic Syndromes ,Transient acantholytic dermatosis ,Lumen (anatomy) ,Sweating ,Dermatology ,Pathology and Forensic Medicine ,law.invention ,Carcinoembryonic antigen ,law ,Biopsy ,medicine ,Humans ,Grover's disease ,Aged ,Tight junction ,medicine.diagnostic_test ,biology ,Staining and Labeling ,business.industry ,Acantholysis ,Antibodies, Monoclonal ,Middle Aged ,medicine.disease ,Carcinoembryonic Antigen ,Sweat Glands ,biology.protein ,Electron microscope ,business - Abstract
Three selected cases of transient acantholytic dermatosis were studied because of their definitive correlation with sweating due to fever and/ or bed-ridden situations. Biopsy specimens were serially sectioned and acantholysis was found in the acrosyringium or traced to connect to the acrosyringium in all biopsy specimens. Carcinoembryonic antigen (CEA) and eccrine gland-specific monoclonal antibody, IKH-4, were positive in acantholytic cells. Electron microscopy revealed electron dense material filling the lumen of intraepidermal eccrine ducts. This material leaked into lateral intercellular spaces of the luminal cells, passing tight junctions. Marked edema and numerous lysosomes were reminiscent of those found when eccrine acrosyringium is formed in the embryo; this suggested that an occluded and damaged eccrine intraepidermal duct was being rebuilt via lysosomal digestion.
- Published
- 1996
42. Berloque Dermatitis Mimicking Child Abuse
- Author
-
Mary Wu Chang and Lisa Moed Gruson
- Subjects
Child abuse ,medicine.medical_specialty ,Injury control ,Erythema ,media_common.quotation_subject ,Poison control ,Humans ,Medicine ,Child Abuse ,Girl ,Diagnostic Errors ,Child ,skin and connective tissue diseases ,media_common ,integumentary system ,Dermatitis, Photoallergic ,business.industry ,Berloque dermatitis ,Photocontact Dermatitis ,Hyperpigmentation ,Dermatology ,Perfume ,Pediatrics, Perinatology and Child Health ,Female ,medicine.symptom ,business - Abstract
Berloque dermatitis is a type of photocontact dermatitis. It occurs after perfumed products containing bergamot (or a psoralen) are applied to the skin followed by exposure to sunlight. Striking linear patterns of hyperpigmentation are characteristic, corresponding to local application of the scented product. In the acute phase, erythema and even blistering can be seen. We report a case of berloque dermatitis in a 9-year-old girl that was initially reported as child abuse. To our knowledge, this is the first report of berloque dermatitis mimicking child abuse. Questioning to elicit a history of perfume application coupled with sunlight exposure should help to prevent this misdiagnosis in children.
- Published
- 2002
43. Cutaneous Anthrax Infection
- Author
-
K. J. Roche, Mary Wu Chang, and Herbert Lazarus
- Subjects
medicine.medical_specialty ,medicine.diagnostic_test ,Erythema ,business.industry ,medicine.medical_treatment ,Magnetic resonance imaging ,General Medicine ,Cutaneous anthrax ,Surgery ,Lesion ,Coronal plane ,Incision and drainage ,medicine ,Left elbow ,medicine.symptom ,Swelling ,business - Abstract
Figure 1. A seven-month-old male infant was hospitalized with a two-day history of swelling of the left arm and a weeping lesion at the left elbow (Panel A). The patient was afebrile but had a 2-cm open sore, with surrounding erythema and induration, that oozed clear yellow fluid. There was nontender swelling and erythema of the entire arm. The white-cell count was 28,100 per cubic millimeter. Incision and drainage of the lesion produced 10 ml of dark red fluid. A coronal, T1-weighted sequence from a magnetic resonance imaging study (Panel B) demonstrated diffuse, severe edema of the subcutaneous tissues extending . . .
- Published
- 2001
44. Genetic association of cutaneous neonatal lupus with HLA class II and tumor necrosis factor α: Implications for pathogenesis.
- Author
-
Robert M. Clancy, Chelsea B. Backer, Xiaoming Yin, Mary Wu Chang, Steven R. Cohen, Lela A. Lee, and Jill P. Buyon
- Subjects
SKIN diseases ,LUPUS erythematosus ,TUMOR necrosis factors ,PHOTOSENSITIVITY disorders ,KERATINOCYTES ,HEART block ,SKIN ,HEART diseases ,NEONATOLOGY - Abstract
Cutaneous neonatal lupus resembles subacute cutaneous lupus erythematosus (SCLE), and photosensitivity is a common symptom. Tumor necrosis factor α (TNFα) release by ultraviolet light–exposed keratinocytes may be exaggerated in SCLE patients who have the haplotype TNFα −308A;DRB1*03. Accordingly, this study was undertaken to seek genetic and histologic evidence for a role of TNFα in the pathogenesis of cutaneous neonatal lupus. DNA was isolated from 83 children (22 with rash, 35 with congenital heart block [CHB], 26 unaffected siblings) and 58 mothers from the Research Registry for Neonatal Lupus. The −308A allele (associated with higher TNFα production), HLA–DRQB1*02, and HLA–DRB1*03 were each present in the majority of children with rash (64%, 68%, and 64%, respectively). The frequency of all 3 6p alleles occurring together in 1 individual was greater in children with rash than in children who had either CHB or no manifestation of neonatal lupus (59% versus 30%; P = 0.02). This association with neonatal lupus rash was equivalent to published findings in a cohort of patients with SCLE, but significantly greater than the association in patients with discoid lupus erythematosus. Prominent TNFα staining in the epidermis was observed in lesional skin from 3 children with rash, but not in skin from a healthy neonate. Taken together, the finding of a genetic predisposition to generate increased levels of TNFα following tissue injury and the histologic demonstration of TNFα in the target organ support the notion that this inflammatory cytokine plays a role in the pathogenesis of cutaneous neonatal lupus. Furthermore, the results of these studies provide evidence of a biologic link between neonatal lupus and the rash of SCLE. [ABSTRACT FROM AUTHOR]
- Published
- 2004
- Full Text
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