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3 results on '"Mary Mahony"'

1. Dose adjustment of follicle-stimulating hormone (FSH) during ovarian stimulation as part of medically-assisted reproduction in clinical studies: a systematic review covering 10 years (2007–2017)

Author

Human Fatemi, Wilma Bilger, Deborah Denis, Georg Griesinger, Antonio La Marca, Salvatore Longobardi, Mary Mahony, Xiaoyan Yin, and Thomas D’Hooghe

Subjects
Follicle-stimulating hormone (FSH), FSH dose adjustment, Recombinant-human FSH, Follitropin, Controlled ovarian stimulation (COS), In vitro fertilization (IVF), Gynecology and obstetrics, RG1-991, Reproduction, QH471-489
Abstract

Abstract Background Individualization of the follicle-stimulating hormone (FSH) starting dose is considered standard clinical practice during controlled ovarian stimulation (COS) in patients undergoing assisted reproductive technology (ART) treatment. Furthermore, the gonadotropin dose is regularly adjusted during COS to avoid hyper- or hypo-ovarian response, but limited data are currently available to characterize such adjustments. This review describes the frequency and direction (increase/decrease) of recombinant-human FSH (r-hFSH) dose adjustment reported in clinical trials. Methods We evaluated the proportion of patients undergoing ART treatment who received ≥ 1 r-hFSH dose adjustments. The inclusion criteria included studies (published Sept 2007 to Sept 2017) in women receiving ART treatment that allowed dose adjustment within the study protocol and that reported ≥ 1 dose adjustments of r-hFSH; studies not allowing/reporting dose adjustment were excluded. Data on study design, dose adjustment and patient characteristics were extracted. Point-incidence estimates were calculated per study and overall based on pooled number of cycles with dose adjustment across studies. The Clopper–Pearson method was used to calculate 95% confidence intervals (CI) for incidence where adjustment occurred in

Published
2021
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2. Shaker-1 mutations reveal roles for myosin VIIA in both development and function of cochlear hair cells

Author

James Walsh, Karen P. Steel, J. Fleming, Mary Mahony, Tim Self, and Steve D. M. Brown

Subjects
MYO7A, Usher syndrome, Mutant, Myosins, Biology, Mice, Hair Cells, Auditory, otorhinolaryngologic diseases, medicine, Animals, Humans, Inner ear, Cilia, Molecular Biology, In Situ Hybridization, DNA Primers, Genetics, Base Sequence, Cell growth, Dyneins, Depolarization, medicine.disease, Mice, Mutant Strains, Cell biology, Electrophysiology, Microscopy, Electron, medicine.anatomical_structure, Animals, Newborn, Myosin VIIa, Mutation, Microscopy, Electron, Scanning, sense organs, Hair cell, Developmental Biology
Abstract

The mouse shaker-1 locus, Myo7a, encodes myosin VIIA and mutations in the orthologous gene in humans cause Usher syndrome type 1B or non-syndromic deafness. Myo7a is expressed very early in sensory hair cell development in the inner ear. We describe the effects of three mutations on cochlear hair cell development and function. In the Myo7a816SB and Myo7a6J mutants, stereocilia grow and form rows of graded heights as normal, but the bundles become progressively more disorganised. Most of these mutants show no gross electrophysiological responses, but some did show evidence of hair cell depolarisation despite the disorganisation of their bundles. In contrast, the original shaker-1 mutants, Myo7ash1, had normal early development of stereocilia bundles, but still showed abnormal cochlear responses. These findings suggest that myosin VIIA is required for normal stereocilia bundle organisation and has a role in the function of cochlear hair cells.

Published
1998

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