224 results on '"Mary Lynch"'
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2. Evaluating the social return on investment of dance movement for wellbeing in the prevention of burnout among healthcare staff: a study protocol
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Mary Lynch, Carolyn Wallace, and Teresa Filipponi
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Medicine - Abstract
Introduction Improvement in the National Health Service (NHS) employees’ mental well-being and staff retention are current key issues. Evidence indicates that dance movement therapy (DMT) has been effective in improving mental health and well-being; however, a social return on investment (SROI) evaluation on DMT interventions aimed at NHS staff has not been performed. This protocol for an SROI study will explore the social value generated from DMT, specifically ‘The Body Moving Self-Compassion’ programme, as measured by the increase in personal well-being and resilience experienced by participants. The SROI evaluation aims to measure the monetary and social value generated through DMT by placing a monetary value which is essential for sound policy in accessing investment while contributing evidence of dance/movement’s impact on health.Methods SROI is a pragmatic form of social cost-benefit analysis which uses quantitative and qualitative methods to value relevant costs, outcomes and associated impact. A mixed-methods approach design (focus group, online questionnaire and semistructured interviews) will be employed in this SROI study. SROI takes a societal perspective and considers relevant and significant outcomes for participants. Monetary values which often do not have a market price are then assigned to these outcomes. Contingent valuation is integrated into this study to estimate individuals’ choices, preferences and values associated with DMT. The social value generated by the identified outcomes will then be estimated in a similar way to cost-benefit analysis, and the ratio of social value generated per £1 invested is then calculated.Ethics and dissemination Ethical approval for this study has been granted by the Faculty of Life Sciences and Education Ethics Subgroup at the University of South Wales, with Reference No. 230 236LR. The findings from this SROI study will result in a report and academic publications.
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- 2024
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3. Nature-based social prescribing programmes: opportunities, challenges, and facilitators for implementation
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Siân de Bell, Julius Cesar Alejandre, Claudia Menzel, Rita Sousa-Silva, Tanja M. Straka, Susanne Berzborn, Max Bürck-Gemassmer, Martin Dallimer, Chris Dayson, Jessica C. Fisher, Annette Haywood, Alina Herrmann, Gisela Immich, Christian S. Keßler, Kristin Köhler, Mary Lynch, Viola Marx, Andreas Michalsen, Pierpaolo Mudu, Hendrik Napierala, Maximilian Nawrath, Sharon Pfleger, Claudia Quitmann, Jonathan P. Reeves, Kevin Rozario, Wolfgang Straff, Katie Walter, Charlotte Wendelboe-Nelson, Melissa R. Marselle, Rachel Rui Ying Oh, and Aletta Bonn
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Green social prescribing ,Nature-based social prescribing ,Environment ,Health ,Policy ,Natural environments ,Environmental sciences ,GE1-350 - Abstract
Background: Evidence on the health benefits of spending time in nature has highlighted the importance of provision of blue and green spaces where people live. The potential for health benefits offered by nature exposure, however, extends beyond health promotion to health treatment. Social prescribing links people with health or social care needs to community-based, non-clinical health and social care interventions to improve health and wellbeing. Nature-based social prescribing (NBSP) is a variant that uses the health-promoting benefits of activities carried out in natural environments, such as gardening and walking. Much current NBSP practice has been developed in the UK, and there is increasing global interest in its implementation. This requires interventions to be adapted for different contexts, considering the needs of populations and the structure of healthcare systems. Methods: This paper presents results from an expert group participatory workshop involving 29 practitioners, researchers, and policymakers from the UK and Germany’s health and environmental sectors. Using the UK and Germany, two countries with different healthcare systems and in different developmental stages of NBSP practice, as case studies, we analysed opportunities, challenges, and facilitators for the development and implementation of NBSP. Results: We identified five overarching themes for developing, implementing, and evaluating NBSP: Capacity Building; Accessibility and Acceptability; Networks and Collaborations; Standardised Implementation and Evaluation; and Sustainability. We also discuss key strengths, weaknesses, opportunities, and threats for each overarching theme to understand how they could be developed to support NBSP implementation. Conclusions: NBSP could offer significant public health benefits using available blue and green spaces. We offer guidance on how NBSP implementation, from wider policy support to the design and evaluation of individual programmes, could be adapted to different contexts. This research could help inform the development and evaluation of NBSP programmes to support planetary health from local and global scales.
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- 2024
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4. Codesign and refinement of an optimised antenatal education session to better inform women and prepare them for labour and birth
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Mariusz Grzeda, Christy Burden, Mary Lynch, Abigail Fraser, Gemma Clayton, Anna Davies, Rachel Plachcinski, Margaret Smith, Michael Larkin, Miriam Toolan, Emma Harvey, Tamarind Russell-Webster, Abi Merriel, Andrew Demetri, Chloë de Souza, Katherine Birchenall, Sonia Barnfield, Lucy Willis, Narendra Mampitiya, Alice Clarke, Eva Larkai, and Kate Rawling
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Medicine (General) ,R5-920 - Abstract
Objective Our objective was to codesign, implement, evaluate acceptability and refine an optimised antenatal education session to improve birth preparedness.Design There were four distinct phases: codesign (focus groups and codesign workshops with parents and staff); implementation of intervention; evaluation (interviews, questionnaires, structured feedback forms) and systematic refinement.Setting The study was set in a single maternity unit with approximately 5500 births annually.Participants Postnatal and antenatal women/birthing people and birth partners were invited to participate in the intervention, and midwives were invited to deliver it. Both groups participated in feedback.Outcome measures We report on whether the optimised session is deliverable, acceptable, meets the needs of women/birthing people and partners, and explain how the intervention was refined with input from parents, clinicians and researchers.Results The codesign was undertaken by 35 women, partners and clinicians. Five midwives were trained and delivered 19 antenatal education (ACE) sessions to 142 women and 94 partners. 121 women and 33 birth partners completed the feedback questionnaire. Women/birthing people (79%) and birth partners (82%) felt more prepared after the class with most participants finding the content very helpful or helpful. Women/birthing people perceived classes were more useful and engaging than their partners. Interviews with 21 parents, a midwife focus group and a structured feedback form resulted in 38 recommended changes: 22 by parents, 5 by midwives and 11 by both. Suggested changes have been incorporated in the training resources to achieve an optimised intervention.Conclusions Engaging stakeholders (women and staff) in codesigning an evidence-informed curriculum resulted in an antenatal class designed to improve preparedness for birth, including assisted birth, that is acceptable to women and their birthing partners, and has been refined to address feedback and is deliverable within National Health Service resource constraints. A nationally mandated antenatal education curriculum is needed to ensure parents receive high-quality antenatal education that targets birth preparedness.
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- 2024
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5. Exploring a career pathway for home support workers in Ireland: a systematic scoping review of the international evidence
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Elizabeth Morrow, Carmel Kelly, Clodagh Killeen, Edward Naessens, and Mary Lynch
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home support workers ,home care ,workforce planning ,career pathway ,ageing population ,person-centred care ,Medicine - Abstract
BackgroundIn prosperous nations like Ireland, home support workers (HSWs) play an increasingly vital role in providing person-centred care to ageing populations. However, challenges such as workforce shortages, role ambiguity, low pay, and limited career advancement, hinder workforce development and career building.MethodA scoping review using key terms for “HSWs” and “career pathways” was conducted following the Joanna Briggs Institute Methodology, examining electronic databases (Web of Science, PubMed, MEDLINE, EMBASE, CINAHL, PscyINFO, Social Care Online, Social Sciences Citation Index). Inclusion criteria were applied, and a thematic analysis followed and inductive-deductive approach.ResultsThe review encompassed 261 relevant articles from different countries. Four key themes were identified: (1) Data-driven decision-making on the future workforce, (2) Attracting and developing a competent and motivated home support workforce, (3) Enhancing working lives and retention at every stage of career pathways, and (4) Crafting career pathways to improve quality and impact.DiscussionLeadership, collaboration, and data-driven decision-making across policy, research and practice are pivotal for expanding and enhancing home support. Emphasising a shift towards preventative self-management models, supported by digitally skilled and regulated HSWs, could enhance independence and quality of care. Clear career structures, professional development, and inclusive organisational environments are essential to attract, retain, and empower a competent and motivated workforce, fostering quality and impact.ConclusionThis scoping review provides foundational evidence to establish career pathways for HSWs, identifying key areas for development such as data collection, care model transformation, career progression structures, and systems for safety and quality improvement.
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- 2024
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6. Petechial Rash and Glomerulonephritis
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William John Jenner, PhD, Gayathri Rajakaruna, PhD, George Asimakopoulos, PhD, and Mary Lynch, MD
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cardiac surgery ,device infection ,echocardiography ,endocarditis ,glomerulonephritis ,patent foramen ovale ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Patent foramen ovale device closure is rarely associated with complications. This case report is believed to be the first description of a patient with infective endocarditis of a patent foramen ovale closure device presenting as glomerulonephritis. This article serves to educate as to this rare device complication and its unusual presentation. (Level of Difficulty: Intermediate.)
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- 2023
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7. Antenatal care in Nepal: a qualitative study into missed opportunities in the first trimesterAJOG Global Reports at a Glance
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Felicity Greenfield, BSc, Mary Lynch, BSc, Nashna Maharjan, MHPE, Miriam Toolan, MBBS, Katie Barnard, BA, Tina Lavender, PhD, Michael Larkin, PhD, Nisha Rai, MD, Meena Thapa, MD, Deborah M. Caldwell, PhD, Christy Burden, MD, Dharma S. Manandhar, HonFRPCH, and Abi Merriel, PhD
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focus groups ,folic acid ,low-income countries ,pregnancy care ,South Asia ,ultrasound scanning ,Gynecology and obstetrics ,RG1-991 - Abstract
BACKGROUND: Use of timely antenatal care has been identified as key to facilitating healthy pregnancies worldwide. Although considerable investment has been made to enhance maternal health services in Nepal, approximately one-third of women do not attend antenatal care until after the first trimester (late). These women miss out on the benefits of screening and interventions that are most effective in the first trimester. OBJECTIVE: This study aimed to identify the missed opportunities of women who do not attend antenatal care in the first trimester, and to explore some of the factors underlying late attendance and consider potential solutions for minimizing these missed opportunities in the future. STUDY DESIGN: This study was conducted in 3 hospitals in Nepal. Focus groups (n=18) with a total of 48 postnatal women and 49 staff members, and 10 individual interviews with stakeholders were conducted. Purposive sampling facilitated the obtainment of a full range of maternity experiences, staff categories, and stakeholder positions. Data were qualitative and analyzed using a thematic approach. RESULTS: Limited awareness among women of the importance of early antenatal care was reported as a key factor behind attendance only after the first trimester. The family and community were described as significant influencers in women's decision-making regarding the timing of antenatal care. The benefits of early ultrasound scanning and effective supplementation in pregnancy were the major missed opportunities. Increasing awareness, reducing cost, and enhancing interprofessional collaboration were suggested as potential methods for improving timely initiation of antenatal care. CONCLUSION: Limited awareness continues to drive late attendance to antenatal care after the first trimester. Investment in services in the first trimester and community health education campaigns are needed to improve this issue and enhance maternal and neonatal outcomes.
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- 2022
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8. Social prescribing for frequent attenders in primary care: An economic analysis
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Mary Lynch and Ceri R. Jones
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social prescribing ,economic analysis (EA) ,mental health ,psychological wellbeing ,primary care ,Public aspects of medicine ,RA1-1270 - Abstract
BackgroundSocial prescribing (SP) is a mechanism to link patients with community groups and third sector organizations. It offers a complimentary approach to the traditional medical models to address psychosocial needs of patients more effectively and in turn aims to reduce demand on the NHS. The aim of this study was to explore the economic benefits related to changes in the use of healthcare resources following a social prescribing intervention in four primary care practices in Wales.MethodsQuantitative data from routine healthcare usage was collected from the 78 participants pre and post-intervention. The participants were grouped into frequent attenders (FA) (n = 21) and frequent (n = 57) non-attenders (FNA), and a cost analysis was conducted to estimate cost variances based on healthcare unit usage over the length of the pilot intervention. These were then extrapolated forward to identify potential healthcare savings.ResultsThe SP as an intervention generated the largest cost saving for FAs. The cost variance when FAs participated in the intervention shows there is a direct cost saving of £6,113 or £78.37 per participant over the 5 months of the intervention.ConclusionsResults suggest there may be a cost saving associated with SP interventions, however caution should be exercised in interpreting the results due to the lack of control group in this study The cost saving were largest for FAs, where the intervention reduced healthcare unit usage as well as actual and inferred impact on associated healthcare costs. This suggests that in practice to generate the maximum cost benefit SP interventions could be targeted at FAs.
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- 2022
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9. User-centered design and agile development of a novel mobile health application and clinician dashboard to support the collection and reporting of patient-reported outcomes for breast cancer care
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Elizabeth Frank, Andrea Pusic, Elena Tsangaris, Maria Edelen, Jessica Means, Madelijn Gregorowitsch, Joanna O’Gorman, Rakasa Pattanaik, Laura Dominici, Michael Hassett, Mary Lynch Witkowski, Kristen Schrieber, and Martha Carnie
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Medical technology ,R855-855.5 ,Surgery ,RD1-811 - Abstract
Objectives There is a need for advancements in health information technology that will transform how patient-reported outcomes (PRO) data are collected, reported, and used in breast cancer care. The objective of this study was to develop an innovative and customizable platform, called imPROVE to support PRO uptake in breast cancer care.Design User-centered design and agile development were employed. Recurrent stakeholder meetings with experts in the field of breast cancer care, in-depth one-on-one qualitative interviews with a clinical sample of patients with breast cancer, and focus groups with Dana-Farber/Harvard Cancer Center (DF/HCC) Breast Cancer Advisory Group members, were used to elicit feedback for the design features and functions of a patient mobile application and clinician dashboard.Setting This study was conducted at two academic hospitals in the USA.Participants Participants included experts in the field of breast cancer care, value-based healthcare, and health information technology, a clinical sample of patients with breast cancer, and members of the DF/HCC Breast Cancer Advisory Group.Main outcome measures imPROVE incorporates the International Consortium for Health Outcomes Measurement (ICHOM) breast cancer standard outcome set as well as the complete BREAST-Q Breast Cancer Module.Results Feedback was elicited from eight stakeholder meetings (n=28 members), interviews with a clinical sample of patients (n=28), and two focus groups with members of the DF/HCC Breast Cancer Advisory Group (n=17 members in each focus group). Participant feedback led to the development of a patient mobile application consisting of five components (myCare, myStory, myResources, myCommunity, and myNotes) and a clinician dashboard that includes an overview table and individual patient profiles with data displays.Conclusions imPROVE has the potential to transform the way we deliver care to patients. Developed from best practices in user-centered design, agile development, and qualitative methods; imPROVE addresses the needs of multiple stakeholders, including patients, clinicians, healthcare administrators, and researchers.
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- 2022
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10. Key components influencing the sustainability of a multi-professional obstetric emergencies training programme in a middle-income setting: a qualitative study
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Kiren Ghag, Rachna Bahl, Cathy Winter, Mary Lynch, Nayda Bautista, Rogelio Ilagan, Matthew Ellis, Isabel de Salis, and Timothy J. Draycott
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Obstetric emergencies, multi-professional training ,Sustainability ,Middle-income setting ,Implementation ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background Multi-professional obstetric emergencies training is one promising strategy to improve maternity care. Sustaining training programmes following successful implementation remains a challenge. Understanding, and incorporating, key components within the implementation process can embed interventions within healthcare systems, thereby enhancing sustainability. This study aimed to identify key components influencing sustainability of PRactical Obstetric Multi-Professional Training (PROMPT) in the Philippines, a middle-income setting. Methods Three hospitals were purposively sampled to represent private, public and teaching hospital settings. Two focus groups, one comprising local trainers and one comprising training participants, were conducted in each hospital using a semi-structured topic guide. Focus groups were audio recorded. Data were analysed using thematic analysis. Three researchers independently coded transcripts to ensure interpretation consistency. Results Three themes influencing sustainability were identified; attributes of local champions, multi-level organisational involvement and addressing organisational challenges. Conclusions These themes, including potential barriers to sustainability, should be considered when designing and implementing training programmes in middle-income settings. When ‘scaling-up’, local clinicians should be actively involved in selecting influential implementation champions to identify challenges and strategies specific to their organisation. Network meetings could enable shared learning and sustain enthusiasm amongst local training teams. Policy makers should be engaged early, to support funding and align training with national priorities.
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- 2021
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11. A Social Return on Investment evaluation of the Emotion-Mind Dynamic (EMD) two phase social prescribing life coaching intervention to support mental health and wellbeing.
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Abraham Makanjuola, Mary Lynch, Ned Hartfiel, Andrew Cuthbert, and Rhiannon Tudor Edwards
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Demography. Population. Vital events ,HB848-3697 - Abstract
Background The COVID-19 pandemic has created excess weighting lists to access Mental Health Services in the UK (Stats Wales, 2021). It is important to find effective solutions to alleviate the pressures that Mental Health services experience. The NHS Five Year Forward View encourages the development of new social prescribing empowerment-based interventions to supplement existing mental health programmes (Mental Health Taskforce, 2016). The EmotionMind Dynamic (EMD) is a lifestyle coaching programme that supports individuals suffering from anxiety or depression referred from the health and social care sectors. EMD offers a unique, non-clinical mixed-modality approach combining coaching, mentoring, counselling skills, teaching and mindfulness. Methods Social Return On Investment (SROI) methodology is applied to evaluate the EMD service. The aim of the SROI analysis is to develop a programme-level theory of change to establish how inputs (e.g. costs, staffing) are converted into outputs (e.g. numbers of clients seen), and subsequently into outcomes that matter to clients impacted by EMD service (e.g. improved mental wellbeing). Wellbeing valuation will quantify and value outcomes using two value sets. The SROI mixed-method approach collects quantitative and qualitative data from questionnaires and interviews with former face-to-face EMD clients as well a new clients, undertaking the online blended learning programme. Findings Initial results indicate that the social prescribing face-to-face EMD programme generated positive social value ratios ranging from £9 to £23 for every £1 invested. In addition, the General Self-Efficacy Scale (GSES) which measures participant’s self-reported self-efficacy and confidence indicated that the face-to-face EMD participants experienced improved mental wellbeing and resilience as a result of participating in the EMD lifestyle coaching programme. Sensitivity analyses was conducted with Social Value Bank (SVB) figures for improved confidence and confirmed assumptions that former EMD clients experienced positive mental wellbeing improvements as a result of undertaking the lifestyle coaching programme. Conclusions This is the first study to undertake an SROI analysis of a social prescribing lifestyle coaching programme aimed at improving mental wellbeing and resilience. Phase one of this novel SROI study of the face-to-face EMD clients indicates that the EMD lifestyle coaching programme has the potential to generate positive social value ratios. Phase two analysis of the online EMD blended learning programme will compare the effectiveness of the two lifestyle coaching formats: face to face and the online blended format to improve mental wellbeing and self-efficacy by participating in this innovative lifestyle coaching programme.
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- 2022
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12. Protocol for the development of a core outcome set for stillbirth care research (iCHOOSE Study)
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Danya Bakhbakhi, Christy Burden, Alexander Edward Heazell, Mary Lynch, Laura Timlin, Soo Downe, Lisa Hinton, Pauline Slade, Abigail Fraser, Vicki Flenady, Anna Davies, Sara Brookes, Margaret Murphy, James M N Duffy, Maggie Redshaw, Kate Mulley, Dimitris Siasakos, Abi Merriel, Aleena Wojcieszek, Heloisa de Oliveira Salgado, Danielle Pollock, Neelam Aggarwal, Irene Attachie, Susannah Leisher, Wanijiru Kihusa, Lindsey Wimmer, Lisa Thorne, Will Hatton, Carla Mereu Keating, Heather Jane Coombs, Dave Coombs, Michelle Fischer, Ali Fischer, Fraser Morton, and Naomi Hepworth
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Medicine - Published
- 2022
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13. A systematic review and narrative synthesis of antenatal interventions to improve maternal and neonatal health in NepalAJOG Global Reports at a Glance
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Miriam Toolan, MBBS, Katie Barnard, MA, Mary Lynch, BSc, Nashna Maharjan, MHPE, Meena Thapa, MD, Nisha Rai, MD, Tina Lavender, PhD, Michael Larkin, PhD, Deborah M. Caldwell, PhD, Christy Burden, MD, Dharma S. Manandhar, Hon FRCPCH, and Abi Merriel, PhD
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antenatal care ,antenatal education ,birth preparedness ,cash incentive ,female community health volunteers ,global health ,Gynecology and obstetrics ,RG1-991 - Abstract
BACKGROUND: Maternal and neonatal mortality rates remain high in many economically underdeveloped countries, including Nepal, and good quality antenatal care can reduce adverse pregnancy outcomes. However, identifying how to best improve antenatal care can be challenging. OBJECTIVE: To identify the interventions that have been investigated in the antenatal period in Nepal for maternal or neonatal benefit. We wanted to understand their scale, location, cost, and effectiveness. STUDY DESIGN: Online bibliographic databases (Cochrane Central, MEDLINE, Embase, CINAHL Plus, British Nursing Index, PsycInfo, Allied and Complementary Medicine) and trial registries (ClinicalTrials.gov and the World Health Organization Clinical Trials Registry Platform) were searched from their inception till May 24, 2020. We included all studies reporting any maternal or neonatal outcome after an intervention in the antenatal period. We screened the studies and extracted the data in duplicate. A meta-analysis was not possible because of the heterogeneity of the interventions and outcomes, so we performed a narrative synthesis of the included studies. RESULTS: A total of 25 studies met our inclusion criteria. These studies showed a variety of approaches toward improving antenatal care (eg, educational programs, incentive schemes, micronutrient supplementation) in different settings (home, community, or hospital-based) and with a wide variety of outcomes. Less than a quarter of the studies were randomized controlled trials, and many were single-site or reported only short-term outcomes. All studies reported having made a positive impact on antenatal care in some way, but only 3 provided a cost-benefit analysis to support implementation. None of these studies focused on the most remote communities in Nepal. CONCLUSION: Our systematic review found good quality evidence that micronutrient supplementation and educational interventions can bring important clinical benefits. Iron and folic acid supplementation significantly reduces neonatal mortality and maternal anemia, whereas birth preparedness classes increase the uptake of antenatal and postnatal care, compliance with micronutrient supplementation, and awareness of the danger signs in pregnancy.
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- 2022
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14. Intergenerational Deliberations for Long Term Sustainability
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Llinos Haf Spencer, Mary Lynch, Gwenlli Mair Thomas, and Rhiannon Tudor Edwards
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social prescribing ,co-production ,co-design ,well-being ,health equity ,social determinants of health ,Technology ,Science (General) ,Q1-390 - Abstract
Grŵp Cynefin, a social housing association in North Wales, United Kingdom (UK) with other partner organisations, had a vision to create a community Hub in the Nantlle Valley to strengthen and support the health and well-being of the local community through the provision of a range of traditional and preventative services. Social prescribing (SP), which is a non-medical support using community assets, would be a part of this new innovative Hub. SP activities would be co-designed and co-produced by current community members. Drawing on the principles of citizens’ assembly deliberations and Future Design, four focus groups (n = 16) were conducted to develop sustainable strategies for SP activities as part of the proposed Hub. Deliberations on the perspectives of future generations were considered along with current community needs. Findings from the focus groups imply that current members of society are open to the concept of taking an inter-generational approach when designing SP activities to address the social and economic needs of the community along with integration of traditional and preventative community health services. Deliberations highlighted that the proposed Hub could strengthen communities and support community health and well-being, by providing a place to socialise and acting as a single point of access for community services, which could promote social cohesion in line with the Well-being for Future Generations (Wales) Act. Applying a long-term thinking approach to citizens’ assembly deliberation design offers a voice to the interests of future generations, providing inter-generational equity.
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- 2023
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15. A cross-sectional study to evaluate antenatal care service provision in 3 hospitals in NepalAJOG Global Reports at a Glance
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Abi Merriel, PhD, Nashna Maharjan, MHPE, Gemma Clayton, PhD, Miriam Toolan, MBBS, Mary Lynch, BSc, Katie Barnard, MA, Tina Lavender, PhD, Michael Larkin, PhD, Nisha Rai, MD, Meena Thapa, MD, Deborah M. Caldwell, PhD, Christy Burden, MD, Dharma S. Manandhar, HonFRCPCH, and Abigail Fraser, MD
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accessing care ,antenatal care ,developing countries ,Nepal ,pregnancy care ,quality improvement ,Gynecology and obstetrics ,RG1-991 - Abstract
BACKGROUND: Globally, many mothers and their babies die during pregnancy and childbirth. A key element of optimizing outcomes is high-quality antenatal care. The Government of Nepal has significantly improved antenatal care and health outcomes through high-level commitment and investment; however, only 69% of patients attend the 4 recommended antenatal appointments. OBJECTIVE: This study aimed to evaluate the quality and perceptions of antenatal care in Nepal to understand compliance with the Nepalese standards. STUDY DESIGN: This cross-sectional study was conducted at a tertiary referral and private hospital in Kathmandu and a secondary hospital in Makwanpur, Nepal. The study recruited 538 female inpatients on postnatal wards during the 2-week data collection period from May 2019 to June 2019. A review of case notes and verbal survey of women to understand the pregnancy information they received and their satisfaction with antenatal care were performed. We created a summary score of the completeness of antenatal care services received ranging from 0 to 50 (50 indicating complete conformity with standards) and investigated the determinants of attending 4 antenatal care visits and patient satisfaction. RESULTS: The median antenatal care attendance was 4 visits at the secondary and referral hospitals and 8 visits at the private hospital. However, 24% of the patients attended
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- 2021
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16. Methadone vs. morphine SR for treatment of neuropathic pain: A randomized controlled trial and the challenges in recruitment
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Mary Lynch, Dwight Moulin, and Jordy Perez
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neuropathic pain ,opioids ,methadone ,study recruitment ,Medicine (General) ,R5-920 ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Introduction Accumulating evidence has identified a number of advantages for methadone over other opioids for the treatment of chronic pain including: agonist action at both μ and δ opioid receptors, N-methyl-d-aspartate (NMDA) antagonist activity and the ability to inhibit the reuptake of monoamines. It was hypothesized that with these three mechanisms of action methadone might be a good option for the treatment of neuropathic pain. Methods This was a double-blind randomized controlled trial comparing methadone to controlled-release morphine. The primary objective was to determine whether methadone is clinically inferior versus noninferior to morphine as an analgesic. Results We attempted recruitment at three academic pain centers over a 3-year period. In the end only 14 participants were able to be recruited; 5 withdrew and only 9 completed the trial. This study was underpowered. All participants showed a mean reduction in pain intensity according to the Numeric Rating Scale for Pain Intensity (morphine 5.86 to 4.38, methadone 6.11 to 4.5) and reported pain relief compared to pretreatment, but the sample size was too small for statistical analysis. Discussion Reasons for challenges in recruitment included tight inclusion and exclusion criteria and high participant burden. In addition, there was significant heterogeneity of patients between the three sites, leading to differences in reasons for exclusion. This included seemingly disparate reasons at the different sites, including few participants who were methadone naïve vs. avoidance or fear of opioids. In the end, we were unable to answer the question of the study.
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- 2019
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17. Parents’ Active Role and ENgagement in The review of their Stillbirth/perinatal death 2 (PARENTS 2) study: a mixed-methods study of implementation
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Danya Bakhbakhi, Christy Burden, Claire Storey, Alexander Edward Heazell, Mary Lynch, Laura Timlin, Dimitrios Siassakos, Jennifer J Kurinczuk, and Charlotte Bevan
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Medicine - Abstract
Objective When a formal review of care takes places after the death of a baby, parents are largely unaware it takes place and are often not meaningfully involved in the review process. Parent engagement in the process is likely to be essential for a successful review and to improve patient safety. This study aimed to evaluate an intervention process of parental engagement in perinatal mortality review (PNMR) and to identify barriers and facilitators to its implementation.Design Mixed-methods study of parents’ engagement in PNMR.Setting Single tertiary maternity unit in the UK.Participants Bereaved parents and healthcare professionals (HCPs).Interventions Parent engagement in the PNMR (intervention) was based on principles derived through national consensus and qualitative research with parents, HCPs and stakeholders in the UK.Outcomes Recruitment rates, bereaved parents and HCPs’ perceptions.Results Eighty-one per cent of bereaved parents approached (13/16) agreed to participate in the study. Two focus groups with bereaved parents (n=11) and HCP (n=7) were carried out postimplementation to investigate their perceptions of the process.Overarching findings were improved dialogue and continuity of care with parents, and improvements in the PNMR process and patient safety. Bereaved parents agreed that engagement in the PNMR process was invaluable and helped them in their grieving. HCP perceived that parent involvement improved the review process and lessons learnt from the deaths; information to understand the impact of aspects of care on the baby’s death were often only found in the parents’ recollections.Conclusions Parental engagement in the PNMR process is achievable and useful for parents and HCP alike, and critically can improve patient safety and future care for mothers and babies. To learn and prevent perinatal deaths effectively, all hospitals should give parents the option to engage with the review of their baby’s death.
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- 2021
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18. An audit on the appropriateness of coronary computed tomography angiography referrals in a tertiary cardiac center
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Ahmed Ali Alderazi and Mary Lynch
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Cardiac imaging ,coronary computed tomography ,coronary computed tomography angiography ,coronary computed tomography angiography appropriateness ,coronary computed tomography angiography referrals ,coronary imaging ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background: In response to growing concerns regarding the overuse of coronary computed tomography angiography (CCTA) in the clinical setting, multiple societies, including the American College of Cardiology Foundation, have jointly published revised criteria regarding the appropriate use of this imaging modality. However, previous research indicates significant discrepancies in the rate of adherence to these guidelines. Aim: To assess the appropriateness of CCTA referrals in a tertiary cardiac center in Bahrain. Methods: This retrospective clinical audit examined the records of patients referred to CCTA between the April 1, 2015 and December 31, 2015 in Mohammed bin Khalifa Cardiac Center. Using information from medical records, each case was meticulously audited against guidelines to categorize it as appropriate, inappropriate, or uncertain. Results: Of the 234 records examined, 176 (75.2%) were appropriate, 47 (20.1%) were uncertain, and 11 (4.7%) were inappropriate. About 74.4% of all referrals were to investigate coronary artery disease (CAD). The most common indication that was deemed appropriate was the detection of CAD in the setting of suspected ischemic equivalent in patients with an intermediate pretest probability of CAD (65.9%). Most referrals deemed inappropriate were requested to detect CAD in asymptomatic patients at low or intermediate risk of CAD (63.6%). Conclusion: This audit demonstrates a relatively low rate of inappropriate CCTA referrals, indicating the appropriate and efficient use of this resource in the Mohammed bin Khalifa Cardiac Center. Agreement on and reclassification of “uncertain” cases by guideline authorities would facilitate a deeper understanding of referral appropriateness.
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- 2017
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19. Can Waterlow score predict 30-day mortality and length of stay in acutely admitted medical patients (aged ≥65 years)? Evidence from a single centre prospective cohort study
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Mary Lynch, Chris Thorn, James Wei Wang, Phillip Smith, Shah-Jalal Sarker, Sophie Elands, Amelia Oliveira, Claire Barratt, and Tom Holme
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Medicine - Abstract
Objective This study aimed to explore the potential for the Waterlow score (WS) to be used as a predictor of 30-day mortality and length of hospital stay (LHS) in acutely admitted medical patients aged 65 years and older.Design Prospective observational cohort study.Setting UK District General Hospital.Subjects 834 consecutive patients aged 65 years and older admitted acutely to medical specialties between 30 May and 22 July 2014.Methods Admission WS (range 4–64) assessment paired with the patient’s status at 30 days in terms of mortality and their LHS.Primary outcomes 30-day mortality and length of inpatient stay.Results 834 consecutive acute medical admissions had their WS recorded. 30-day mortality was 13.1% (109 deaths). A significant difference in the distribution of WS (p
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- 2019
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20. Role of Health Care Professionals in Multidisciplinary Pain Treatment Facilities in Canada
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Philip Peng, Jennifer N Stinson, Manon Choiniere, Dominique Dion, Howard Intrater, Sandra LeFort, Mary Lynch, May Ong, Saifee Rashiq, Gregg Tkachuk, Yves Veillette, and the STOPPAIN Investigators Group
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Medicine (General) ,R5-920 - Abstract
PURPOSE: To examine the role of health care professionals in multidisciplinary pain treatment facilities (MPTF) for the treatment of chronic pain across Canada.
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- 2008
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21. Nonmedical Use of Prescription Opioids: What Is the Real Problem?
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Mary Lynch
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Medicine (General) ,R5-920 - Published
- 2013
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22. Use of Opioid Analgesics for the Treatment of Chronic Noncancer Pain - A Consensus Statement and Guidelines from the Canadian Pain Society, 2002
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Roman D Jovey, Jeffrey Ennis, Jacqueline Gardner-Nix, Brian Goldman, Helen Hays, Mary Lynch, and Dwight Moulin
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Medicine (General) ,R5-920 - Published
- 2003
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23. El enfoque de la conducta verbal: Cómo enseñar a niños con autismo y trastornos relacionados
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Barbera, Mary Lynch, primary and Ramussen, Tracy, additional
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- 2022
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24. The Cost of a Nutritious Diet for Households Including People Living with HIV/AIDS in Nova Scotia: Findings and Lessons Learned by FoodNOW 2020 to 2022
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Abigail Clarke, Jessica Mannette, Barb Hamilton-Hinch, Mary Lynch, Patricia Williams, Shannan Grant, and Phillip Joy
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Nutrition and Dietetics ,Medicine (miscellaneous) ,General Medicine - Abstract
Purpose: FoodNOW (Food to eNhance Our Wellness) engaged in assessment of simulated households that include a person living with HIV/AIDS (PLWHA) in Nova Scotia to determine if a basic nutritious diet is affordable. Methods: We used supermarket websites to cost food and beverage items listed in the National Nutritious Food Basket (NNFB) for simulated households, each with a PLWHA. Food costing methodologies were co-developed and adapted with community members in response to barriers presented by the COVID-19 pandemic. Results: We found that simulated households, each with one PLWHA, that had a potential deficit after monthly expenses were a household of four on Income Assistance (−$1,058.70), a lone mother with two children on Income Assistance (−$973.65), a lone man on Income Assistance (−$677.40), and a household of four with one minimum-wage earner (−$383.45). Conclusions: Nova Scotia households with a PLWHA living on Income Assistance or with a minimum-wage earner cannot reasonably afford a nutritious diet in addition to basic household expenses. Using these food costing data can allow dietitians to efficiently inform government action and policy change to improve the health and wellness of individuals and families.
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- 2023
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25. Social Return on Investment of Social Prescribing via a Diabetes Technician for Preventing Type 2 Diabetes Progression
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Edwards, Adam Skinner, Ned Hartfiel, Mary Lynch, Aled Wyn Jones, and Rhiannon Tudor
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Type 2 Diabetes Mellitus (T2DM) ,prediabetes ,social return on investment (SROI) ,social prescribing (SP) ,physical activity (PA) ,overall health - Abstract
In Wales, the prevalence of Type 2 Diabetes Mellitus (T2DM) has increased from 7.3% in 2016 to 8% in 2020, creating a major concern for the National Health Service (NHS). Social prescribing (SP) has been found to decrease T2DM prevalence and improve wellbeing. The MY LIFE programme, a scheme evaluated between June 2021 and February 2022 in the Conwy West Primary Care Cluster, aimed to prevent T2DM by referring prediabetic patients with a BMI of ≥30 to a diabetes technician (DT), who then signposted patients to community-based SP programmes, such as the National Exercise Referral Scheme (NERS), KindEating, and Slimming World. Although some patients engaged with SP, others chose to connect only with the DT. A Social Return on Investment (SROI) analysis was conducted to evaluate those patients who engaged with the DT plus SP, and those who connected solely with the DT. Relevant participant outcomes included ‘mental wellbeing’ and ‘good overall health’, which were measured at baseline (n = 54) and at the eight-week follow-up (n = 24). The estimated social value for every GBP 1 invested for participants who engaged with the ‘DT only’ ranged from GBP 4.67 to 4.70. The social value for participants who engaged with the ‘DT plus SP programme’ ranged from GBP 4.23 to 5.07. The results indicated that most of the social value generated was associated with connecting with the DT.
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- 2023
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26. Exploring current nutritional programming and resources available to people living with HIV or AIDS in Canada: a scoping review
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Jessica Mannette, Yingying Zhang, Melissa Rothfus, Chelsey Purdy, Winta Tesfatsion, Mary Lynch, Barbara Hamilton-Hinch, Patricia L. Williams, Phillip Joy, and Shannan Grant
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General Nursing - Published
- 2023
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27. Data from The MTAP-CDKN2A Locus Confers Susceptibility to a Naturally Occurring Canine Cancer
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Elaine A. Ostrander, Heidi G. Parker, Catherine André, Gerard R. Rutteman, Matthew Breen, Francis Galibert, Mary Lynch, Danielle M. Karyadi, Maud Rimbault, Patrick Devauchelle, Andrea Gröne, Erika M. Kwon, Jerome Abadie, John Cullen, Daniel L. Faden, Emmett V. Schmidt, Suzanne A. Erich, Edouard Cadieu, Benoit Hedan, and Abigail L. Shearin
- Abstract
Background: Advantages offered by canine population substructure, combined with clinical presentations similar to human disorders, makes the dog an attractive system for studies of cancer genetics. Cancers that have been difficult to study in human families or populations are of particular interest. Histiocytic sarcoma is a rare and poorly understood neoplasm in humans that occurs in 15% to 25% of Bernese Mountain Dogs (BMD).Methods: Genomic DNA was collected from affected and unaffected BMD in North America and Europe. Both independent and combined genome-wide association studies (GWAS) were used to identify cancer-associated loci. Fine mapping and sequencing narrowed the primary locus to a single gene region.Results: Both populations shared the same primary locus, which features a single haplotype spanning MTAP and part of CDKN2A and is present in 96% of affected BMD. The haplotype is within the region homologous to human chromosome 9p21, which has been implicated in several types of cancer.Conclusions: We present the first GWAS for histiocytic sarcoma in any species. The data identify an associated haplotype in the highly cited tumor suppressor locus near CDKN2A. These data show the power of studying distinctive malignancies in highly predisposed dog breeds.Impact: Here, we establish a naturally occurring model of cancer susceptibility due to CDKN2 dysregulation, thus providing insight about this cancer-associated, complex, and poorly understood genomic region. Cancer Epidemiol Biomarkers Prev; 21(7); 1019–27. ©2012 AACR.
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- 2023
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28. Supplementary Data 1-9 from The MTAP-CDKN2A Locus Confers Susceptibility to a Naturally Occurring Canine Cancer
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Elaine A. Ostrander, Heidi G. Parker, Catherine André, Gerard R. Rutteman, Matthew Breen, Francis Galibert, Mary Lynch, Danielle M. Karyadi, Maud Rimbault, Patrick Devauchelle, Andrea Gröne, Erika M. Kwon, Jerome Abadie, John Cullen, Daniel L. Faden, Emmett V. Schmidt, Suzanne A. Erich, Edouard Cadieu, Benoit Hedan, and Abigail L. Shearin
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PDF file - 493K, The MTAP-CDKN2A Locus Confers Susceptibility to Cancer in a Naturally Occurring Canine Model
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- 2023
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29. Supplementary Figures 1-5, Table 1 from The Connectivity Map Links Iron Regulatory Protein-1–Mediated Inhibition of Hypoxia-Inducible Factor-2a Translation to the Anti-inflammatory 15-deoxy-Δ12,14-Prostaglandin J2
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Othon Iliopoulos, Todd R. Golub, Emmett Schmidt, Christopher Neil, Mary Lynch, Benjamin L. Ebert, Justin Lamb, and Michael Zimmer
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Supplementary Figures 1-5, Table 1 from The Connectivity Map Links Iron Regulatory Protein-1–Mediated Inhibition of Hypoxia-Inducible Factor-2a Translation to the Anti-inflammatory 15-deoxy-Δ12,14-Prostaglandin J2
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- 2023
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30. Supplementary Figure 3 from Heat Shock Protein B8, a Cyclin-Dependent Kinase–Independent Cyclin D1 Target Gene, Contributes to Its Effects on Radiation Sensitivity
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Emmett V. Schmidt, Mary Lynch, Cuiqi Li, Chuanwei Yang, and Sally Trent
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Supplementary Figure 3 from Heat Shock Protein B8, a Cyclin-Dependent Kinase–Independent Cyclin D1 Target Gene, Contributes to Its Effects on Radiation Sensitivity
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- 2023
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31. Supplementary Methods and Materials, Tables 1-3 from c-myc Repression of TSC2 Contributes to Control of Translation Initiation and Myc-Induced Transformation
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Emmett V. Schmidt, Mary Lynch, Li Chen, and Michael J. Ravitz
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Supplementary Methods and Materials, Tables 1-3 from c-myc Repression of TSC2 Contributes to Control of Translation Initiation and Myc-Induced Transformation
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- 2023
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32. Supplementary Figure 2 from c-myc Repression of TSC2 Contributes to Control of Translation Initiation and Myc-Induced Transformation
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Emmett V. Schmidt, Mary Lynch, Li Chen, and Michael J. Ravitz
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Supplementary Figure 2 from c-myc Repression of TSC2 Contributes to Control of Translation Initiation and Myc-Induced Transformation
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- 2023
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33. Supplementary Figure 1 from c-myc Repression of TSC2 Contributes to Control of Translation Initiation and Myc-Induced Transformation
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Emmett V. Schmidt, Mary Lynch, Li Chen, and Michael J. Ravitz
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Supplementary Figure 1 from c-myc Repression of TSC2 Contributes to Control of Translation Initiation and Myc-Induced Transformation
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- 2023
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34. Supplementary Figure 2 from Heat Shock Protein B8, a Cyclin-Dependent Kinase–Independent Cyclin D1 Target Gene, Contributes to Its Effects on Radiation Sensitivity
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Emmett V. Schmidt, Mary Lynch, Cuiqi Li, Chuanwei Yang, and Sally Trent
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Supplementary Figure 2 from Heat Shock Protein B8, a Cyclin-Dependent Kinase–Independent Cyclin D1 Target Gene, Contributes to Its Effects on Radiation Sensitivity
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- 2023
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35. Supplementary Materials and Methods, Figure Legends 1-3 from Heat Shock Protein B8, a Cyclin-Dependent Kinase–Independent Cyclin D1 Target Gene, Contributes to Its Effects on Radiation Sensitivity
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Emmett V. Schmidt, Mary Lynch, Cuiqi Li, Chuanwei Yang, and Sally Trent
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Supplementary Materials and Methods, Figure Legends 1-3 from Heat Shock Protein B8, a Cyclin-Dependent Kinase–Independent Cyclin D1 Target Gene, Contributes to Its Effects on Radiation Sensitivity
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- 2023
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36. Data from c-myc Repression of TSC2 Contributes to Control of Translation Initiation and Myc-Induced Transformation
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Emmett V. Schmidt, Mary Lynch, Li Chen, and Michael J. Ravitz
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The c-myc oncogene plays a key role in cellular growth control, and translation initiation factors are among the transcriptional targets of Myc. Here, we describe a defect in translation initiation control in myc-null cells due to alterations in the mammalian target of rapamycin (mTOR) pathway. Myc loss increased sensitivity to dominant inhibition of eukaryotic translation initiation factor 4E function. Polysomal profiles of myc−/− cells revealed decreased translation initiation rates, which were accompanied by decreased 40S/60S ribosomal subunit ratios. Because the 40S small ribosomal subunit contains the key regulatory ribosomal protein S6 (rpS6), we considered that myc loss might affect expression of components of the mTOR signaling pathway that regulate rpS6 function. Among mTOR signaling components, Myc directly affected transcription of tuberous sclerosis 2 (TSC2), as shown by quantitative mRNA analysis and by Myc binding to its promoter in chromatin immunoprecipitation assays. Importantly, Myc acted as a strong and direct repressor for TSC2 expression because its loss increased TSC2 mRNA in myc-null and in HL60 shRNA experiments, activation of a mycER construct in myc−/− cells suppressed TSC2 induction in a myc box II–dependent manner, and mycER activation recruited Myc to the TSC2 promoter. The biological significance of the effect of Myc on TSC2 expression was shown by markedly reduced TSC2 mRNA levels in myc-transformed cells, stimulation of S6 kinase activity in myc-null cells by TSC2 siRNA, and decreased Myc-induced soft agar colony formation following retroviral transduction of TSC2. Together, these findings show that regulation of TSC2 can contribute to the effects of Myc on cell proliferation and neoplastic growth. [Cancer Res 2007;67(23):11209–17]
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- 2023
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37. Supplementary Figure 1 from Heat Shock Protein B8, a Cyclin-Dependent Kinase–Independent Cyclin D1 Target Gene, Contributes to Its Effects on Radiation Sensitivity
- Author
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Emmett V. Schmidt, Mary Lynch, Cuiqi Li, Chuanwei Yang, and Sally Trent
- Abstract
Supplementary Figure 1 from Heat Shock Protein B8, a Cyclin-Dependent Kinase–Independent Cyclin D1 Target Gene, Contributes to Its Effects on Radiation Sensitivity
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- 2023
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38. Data from Heat Shock Protein B8, a Cyclin-Dependent Kinase–Independent Cyclin D1 Target Gene, Contributes to Its Effects on Radiation Sensitivity
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Emmett V. Schmidt, Mary Lynch, Cuiqi Li, Chuanwei Yang, and Sally Trent
- Abstract
Overexpression of cyclin D1 is associated with many cancers, and its overexpression is especially associated with a poor prognosis in breast cancer. Paradoxically, cyclin D1 is known to enhance radiation sensitivity, a finding that has not yet been therapeutically exploited. Proposed cyclin D1 functions that could be involved in this effect include cyclin-dependent kinase (CDK)–dependent phosphorylation of retinoblastoma gene product (pRb), titration of p21/p27 complexes, and less well-characterized effects on gene expression. In this report, we sought to clarify the functions of cyclin D1 that might contribute to enhanced radiation sensitivity. Breast cancer cells stably overexpressing a cyclin D1 mutant (KE) that cannot interact with its CDK partners to phosphorylate pRb were as radiation sensitive as those expressing wild-type D1. Although cyclin D1 has been proposed to affect radiation sensitivity through interactions with p21, a cyclin D1 mutant defective for p21 interactions also increased radiation sensitivity. Cyclin D1 overexpression is generally confined to hormone receptor–positive breast cancers, wherein standard therapies include both radiation and hormonal therapies. Among several proposed CDK-independent cyclin D1 targets, we have identified heat shock protein B8 (HSPB8) as a target particularly associated with cyclin D1 and ER-positive tumors. We therefore evaluated its potential contribution to radiation sensitivity. Overexpression of HSPB8 markedly increased radiation sensitivity, and HSPB8 small interfering RNA blocked cyclin D1's enhancement of radiation sensitivity. Taken together, our results show that some of cyclin D1's effects on radiation sensitivity are CDK and p21 independent and identify HSPB8 as a candidate CDK-independent cyclin D1 target that can mediate its effects. [Cancer Res 2007;67(22):10774–81]
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- 2023
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39. A cross-sectional study to evaluate antenatal care service provision in 3 hospitals in Nepal
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Mary Lynch, Nishna Rai, Meena Thapa, Tina Lavender, Michael Larkin, Abi Fraser, Christy Burden, Abi Merriel, Deborah M Caldwell, Gemma L Clayton, Nashna Maharjan, Dharma S Manandhar, Miriam Toolan, and Katie Barnard
- Subjects
medicine.medical_specialty ,Pregnancy ,Referral ,business.industry ,Cross-sectional study ,Attendance ,Psychological intervention ,General Medicine ,developing countries ,service evaluation ,medicine.disease ,pregnancy care ,quality improvement ,accessing care ,Patient satisfaction ,Health promotion ,antenatal care ,Nepal ,Family medicine ,Medicine ,Childbirth ,business - Abstract
BACKGROUND: Globally, many mothers and their babies die during pregnancy and childbirth. A key element of optimizing outcomes is high- quality antenatal care. The Government of Nepal has significantly improved antenatal care and health outcomes through high-level commitment and investment; however, only 69% of patients attend the 4 recommended antenatal appointments.OBJECTIVE: This study aimed to evaluate the quality and perceptions of antenatal care in Nepal to understand compliance with the Nepalese standards.STUDY DESIGN: This cross-sectional study was conducted at a tertiary referral and private hospital in Kathmandu and a secondary hos- pital in Makwanpur, Nepal. The study recruited 538 female inpatients on postnatal wards during the 2-week data collection period from May 2019 to June 2019. A review of case notes and verbal survey of women to understand the pregnancy information they received and their sat- isfaction with antenatal care were performed. We created a summary score of the completeness of antenatal care services received ranging from 0 to 50 (50 indicating complete conformity with standards) and investigated the determinants of attending 4 antenatal care visits and patient satisfaction.RESULTS: The median antenatal care attendance was 4 visits at the secondary and referral hospitals and 8 visits at the private hospital. However, 24% of the patients attended CONCLUSION: Few women achieved full compliance with the Nepali antenatal care standards; however, some services were delivered well. To improve, each antenatal contact needs to meet its clinical aims and be respectful. To achieve this communication and counseling training for staff, investment in health promotion and delivery of core services are needed. It is important that these interventions address key issues, such as attendance in the first trimester of pregnancy, improving privacy and optimizing communication around danger signs. However, they must be designed alongside staff and service users and their efficacy tested before widespread investment or implementation.
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- 2022
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40. Legacy thinking for long term sustainability: Innovative approach applied in the development of a codesigned co-produced Social Prescribing intervention
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Llinos Haf Spencer, Mary Lynch, Gwenlli Thomas, and Rhiannon Tudor Edwards
- Abstract
Background A North Wales housing association offer a social prescription (SP) service within an innovative health and well-being Hub, currently being planned in the Nantlle Valley, Northwest Wales. In line with the requirement of Welsh Government policy, Grŵp Cynefin sought to engage the community in the development of the SP intervention through a co-design and co-production approach. Method Drawing from the principles of citizen assembly deliberations and Future Design four focus groups (n = 16) were conducted to develop sustainable strategies, a novel approach was applied to the focus groups. The “Today Groups” deliberated on the well-being of the community today, and the “Legacy Groups” deliberated on the well-being of future generations in developing SP interventions and the well-being Hub as a whole.
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- 2022
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41. Measles outbreak investigation process in low- and middle-income countries: a systematic review of the methods and costs of contact tracing
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Mary Lynch, Jaci C. Huws, and Etheldreda L Mbivnjo
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medicine.medical_specialty ,Low- and middle-income countries ,business.industry ,030503 health policy & services ,Public health ,Measles outbreak ,Public Health, Environmental and Occupational Health ,Outbreak ,Review Article ,Cochrane Library ,medicine.disease ,Measles ,03 medical and health sciences ,Critical appraisal ,0302 clinical medicine ,Contact tracing ,Economic cost ,Environmental health ,Economic costs ,Global health ,medicine ,030212 general & internal medicine ,0305 other medical science ,business - Abstract
Aim The occurrence of measles outbreaks has increased, and previously measles-free countries are experiencing a resurgence, making measles elimination by 2020 unlikely. Therefore, outbreak prevention and rapid response strategies will need to be intensified. This systematic review therefore examines whether contact tracing (CT) as compared to no CT is an effective means of reducing measles spread during outbreaks in low- and middle-income countries (LMICs). Subject and methods A systematic review was conducted by searching six databases (CINAHL, Global Health, Medline, Cochrane Library, Web of Science and PubMed). The 17 included articles were appraised using the Critical Appraisal Skills Programme checklists and analysed using a narrative synthesis. Results CT is often used alongside mass communication strategies and hospital record checks. Interviewing measles cases to identify contacts, and considering everyone who has shared a space with a case as a contact are common CT methods. Also, CT can be done backwards and/or forwards with the measles case as the focal point of the investigation process. The cost per case of an outbreak response dominated by CT is high especially in terms of labour for the health sector and productivity losses for households. However, overall outbreak expenditure can be low if CT results in fewer and less severe measles cases and a short outbreak duration. Conclusion CT data as a standalone and comparative active surveillance approach in LMICs is scarce. If CT is initiated early, it can prevent large outbreaks, thereby reducing the economic burden of measles and drive LMICs towards measles elimination. Supplementary Information The online version contains supplementary material available at 10.1007/s10389-021-01590-2.
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- 2021
42. Key components influencing the sustainability of a multi-professional obstetric emergencies training programme in a middle-income setting: a qualitative study
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Tim Draycott, Isabel O C de Salis, Nayda Bautista, Kiren Ghag, Rogelio Ilagan, Mary Lynch, Matthew Ellis, Cathy Winter, and Rachna Bahl
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Philippines ,education ,Psychological intervention ,Health informatics ,Middle-income setting ,Health administration ,03 medical and health sciences ,0302 clinical medicine ,Pregnancy ,Humans ,Medicine ,Maternal Health Services ,030212 general & internal medicine ,Qualitative Research ,Obstetric emergencies, multi-professional training ,Medical education ,030219 obstetrics & reproductive medicine ,business.industry ,Health Policy ,Nursing research ,Focus group ,Obstetrics ,Sustainability ,Implementation ,Female ,Emergencies ,Thematic analysis ,Public aspects of medicine ,RA1-1270 ,business ,Research Article ,Qualitative research - Abstract
Background Multi-professional obstetric emergencies training is one promising strategy to improve maternity care. Sustaining training programmes following successful implementation remains a challenge. Understanding, and incorporating, key components within the implementation process can embed interventions within healthcare systems, thereby enhancing sustainability. This study aimed to identify key components influencing sustainability of PRactical Obstetric Multi-Professional Training (PROMPT) in the Philippines, a middle-income setting. Methods Three hospitals were purposively sampled to represent private, public and teaching hospital settings. Two focus groups, one comprising local trainers and one comprising training participants, were conducted in each hospital using a semi-structured topic guide. Focus groups were audio recorded. Data were analysed using thematic analysis. Three researchers independently coded transcripts to ensure interpretation consistency. Results Three themes influencing sustainability were identified; attributes of local champions, multi-level organisational involvement and addressing organisational challenges. Conclusions These themes, including potential barriers to sustainability, should be considered when designing and implementing training programmes in middle-income settings. When ‘scaling-up’, local clinicians should be actively involved in selecting influential implementation champions to identify challenges and strategies specific to their organisation. Network meetings could enable shared learning and sustain enthusiasm amongst local training teams. Policy makers should be engaged early, to support funding and align training with national priorities.
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- 2021
43. Hypertrophic Cardiomyopathy and Arrhythmias as Phenotype Spectrum of Emery Dreifuss Muscular Dystrophy: First Case Report in Bahrain
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Mary Lynch, Vinayak Vadgaonkar, Rajesh Jayakumar, and Cristina Skrypnyk
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General Medicine - Abstract
Muscular dystrophies are a heterogeneous group of inherited disorders characterized by progressive wasting and weakness of the skeletal muscles. The clinical spectrum ranges from early presentation with severe clinical features in childhood to onset in adulthood with less severe clinical symptoms and slow progression. This frequently raises difficulties in diagnosis. The predominant features may be cardiac, and this may lead to a complex diagnosis. Emery Driefuss Muscular dystrophy (EDMD) is a rare form of limb girdle muscular dystrophy. The prevalence is less than 1:100,000 individuals. The condition may be associated with significant muscular cardiac abnormalities which is responsible for mortality in these patients. The authors describe a case of hypertrophic cardiomyopathy in which limb girdle muscular dystrophy was suspected and subsequently confirmed by genetic studies as part of the phenotypic spectrum of Xlinked EDMD. This is the first diagnosed case of EDMD in Bahrain. Keywords: Bahrain, Hypertrophic Cardiomyopathy, Limb-girdle muscular dystrophies, Muscular dystrophies, Skeletal muscles
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- 2021
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44. Interventions, outcomes and outcome measurement instruments in stillbirth care research: A systematic review to inform the development of a core outcome set
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Danya Bakhbakhi, Dimitrios Siassakos, Anna Davies, Abi Merriel, Katie Barnard, Emma Stead, Clare Shakespeare, James Duffy, Lisa Hinton, Karolina McDowell, Anna Lyons, Margaret Redshaw, Vicki Flenady, Alexander Heazell, Laura Timlin, Mary Lynch, Soo Downe, Pauline Slade, Lisa Thorne, Heatherjane Coombs, Aleena Wojcieszek, Margaret Murphy, Heloisa Salgado, Lindsey Wimmer, Danielle Pollock, Neelam Aggarwal, Susannah Leisher, Kate Mulley, Irene Attachie, Bethany Atkins, Christy Burden, and Abigail Fraser
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Stillbirth care research ,Stillbirth - Abstract
Background A core outcome set could address inconsistent outcome reporting and improve evidence for stillbirth care research, which has been identified as an important research priority. Objectives To identify outcomes and outcome measurement instruments reported by studies evaluating interventions after the diagnosis of a stillbirth. Search strategy Amed, BNI, CINAHL, ClinicalTrials.gov, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, Embase, MEDLINE, PsycINFO, and WHO ICTRP from 1998 to August 2021. Selection criteria Randomised and non-randomised comparative or non-comparative studies reporting a stillbirth care intervention. Data collection and analysis Interventions, outcomes reported, definitions and outcome measurement tools were extracted. Main results 40 randomised and 200 non-randomised studies were included. 58 different interventions were reported, labour and birth care (52 studies), hospital bereavement care (28 studies), clinical investigations (116 studies), care in a multiple pregnancy (2 studies), psychosocial support (28 studies) and care in a subsequent pregnancy (14 studies). 391 unique outcomes were reported and organised into 14 outcome domains: labour and birth; postpartum; delivery of care; investigations; multiple pregnancy; mental health; emotional functioning; grief and bereavement; social functioning; relationship; whole person; subsequent pregnancy; subsequent children and siblings and economic. 242 outcome measurement instruments were used, with 0-22 tools per outcome. Conclusions Heterogeneity in outcome reporting, outcome definition and measurement tools in care after stillbirth exists. Considerable research gaps on specific intervention types in stillbirth care were identified. A core outcome set is needed to standardise outcome collection and reporting for stillbirth care research.
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- 2022
45. SYSTEMATIC REVIEW EXPLORING THE IMPACT OF SOCIO-CULTURAL FACTORS ON PAIN MANAGEMENT APPROACHES IN SUB- SAHARAN AFRICA
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Henrietta Obaabeng Dompreh, Mary Lynch, and Mary Longworth
- Abstract
AimThe experience and expression of pain are influenced by numerous factors of which culture and the society plays a major role especially in SSA. However, few studies have focused on the impact of cultural influences on pain assessment and management in SSA. This systemic review examines pain prevalence and its intensity/severity, the socio-cultural factors that affect pain management and the extent to which socio-cultural practices influence pain assessment and management in SSA.MethodsApplying the Preferred Reporting Items for Systemic Reviews and Meta-Analyses (PRISMA) guidelines, a systematic literature search was conducted. Seven electronic databases were searched, and a strict inclusion and exclusion criteria applied to the retrieve articles along with a robust filtering to identify eligible peer reviewed literature. The review process concluded with 24 eligible articles and following the Grades of Recommendation, Assessment, Development and Evaluation (GRADE) approach was applied to assess the quality of the included literature and thematic narrative analysis was conducted.ResultsThe analysis findings identified that there are sociocultural barriers to effective pain management from the perspective of different subcultures in SSA. The evidence suggests that religious/spiritual and inherited beliefs, along with limited knowledge and health literacy influence the experience and pain management approaches applied in SSA. In addition, results indicate that, resource constraints and cultural and societal norms impact on access and use of pain management among the population in SSA.ConclusionHealthcare professionals should be aware of how the society, cultural and beliefs of their patients influence their expression of pain and subsequent pain management. Under-treatment or over-treatment might occur if health workers are unaware or do not consider the cultural norms associated with pain and pain expression, due to the subjective and individual nature of pain.
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- 2022
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46. User-centered design and agile development of a novel mobile health application and clinician dashboard to support the collection and reporting of patient-reported outcomes for breast cancer care
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Tsangaris, Elena, primary, Edelen, Maria, additional, Means, Jessica, additional, Gregorowitsch, Madelijn, additional, O’Gorman, Joanna, additional, Pattanaik, Rakasa, additional, Dominici, Laura, additional, Hassett, Michael, additional, Witkowski, Mary Lynch, additional, Schrieber, Kristen, additional, Frank, Elizabeth, additional, Carnie, Martha, additional, and Pusic, Andrea, additional
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- 2022
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47. A systematic review and narrative synthesis of antenatal interventions to improve maternal and neonatal health in Nepal
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Nashna Maharjan, Michael Larkin, Miriam Toolan, Nisha Rai, Dharma S Manandhar, Christy Burden, Mary Lynch, Tina Lavender, Abi Merriel, Deborah M Caldwell, Katie Barnard, and Meena Thapa
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Postnatal Care ,medicine.medical_specialty ,neonatal mortality ,MEDLINE ,Psychological intervention ,global health ,PsycINFO ,CINAHL ,wa_310 ,law.invention ,antenatal care ,systematic review ,Randomized controlled trial ,law ,wq_500 ,medicine ,maternity incentive ,cash incentive ,maternal mortality ,business.industry ,birth preparedness ,General Medicine ,female community health volunteers ,Clinical trial ,ws_420 ,participatory learning ,micronutrients ,Family medicine ,antenatal education ,business ,Developed country - Abstract
Background: Maternal and neonatal mortality rates remain high in many less economically developed countries, including Nepal. Good quality antenatal care can reduce adverse pregnancy outcomes; however, identifying how best to improve antenatal care can be challenging. Objectives: Our objective was to identify interventions for maternal or neonatal benefit that have been investigated in in the antenatal period in Nepal. We wanted to understand their scale, location, cost, and effectiveness. Study design: Online bibliographic databases (Cochrane Central, Medline, Embase, CINAHL Plus, British Nursing Index, PsycInfo, Allied and Complementary Medicine) and trial registries (ClinicalTrials.gov and the World Health Organization Clinical Trials Registry Platform) were searched from their inception until 24th May 2020. We included all studies reporting any maternal or neonatal outcome following an intervention in the antenatal period. We screened studies and extracted data in duplicate. Meta-analysis was not possible due to the heterogeneity of interventions and outcomes, so we performed a narrative synthesis of the included studies. Results: Twenty-five studies met our inclusion criteria. These studies showed a variety of approaches to improving antenatal care (e.g. educational programs, incentive schemes, micronutrient supplementation) in different settings (home, community or hospital-based) and with a wide variety of outcomes. Less than a quarter of the studies were randomized controlled trials, and many were single-site or reported only short-term outcomes. All studies reported having made a positive impact on antenatal care in some way but only three provided a cost-benefit analysis to support implementation. None of these studies focused on the most remote communities in Nepal. Conclusions: Our systematic review found good quality evidence that micronutrient supplementation and educational interventions can bring important clinical benefits. Iron folic acid supplementation significantly reduces neonatal mortality and maternal anaemia, while birth preparedness classes increase uptake of antenatal and postnatal care, increase compliance with micronutrient supplementation, and increase awareness of danger signs in pregnancy. Funding: Project funding through University of Bristol Global Challenges Research Fund (GCRF) and salary support from National Institute for Health and Research (NIHR).
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- 2022
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48. Child-Centered and Nutrition-Sensitive Green Spaces: Policy Recommendations for Childhood Obesity Prevention in the Philippines’ Urban Poor Communities
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Julius Cesar Alejandre, Princess Jean Algones, Nasudi Soluta, Rachel Henry, and Mary Lynch
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History ,Sociology and Political Science ,Literature and Literary Theory ,Health, Toxicology and Mutagenesis ,General Chemical Engineering ,Developmental and Educational Psychology ,General Materials Science ,General Medicine ,General Chemistry ,Toxicology ,Condensed Matter Physics ,Language and Linguistics ,Education - Abstract
Evidence suggests that green spaces benefit children’s physical activity and healthy eating behaviors. However, inequalities on green space availability and accessibility in deprived urban communities in the Philippines compromise the generation of these health outcomes. Urban planning and development in the country mostly focus on developing roads, buildings, and other ‘gray spaces’ with limited considerations on the value of nature-based public health interventions. In this policy perspective, we examined existing evidence about the impacts of green spaces on childhood obesity and the determinants that influence green space use among children. We then proposed policy measures that could help in the development of child-centered and nutrition-sensitive green spaces in the country’s urban poor communities. To optimize the health-promoting benefits of green spaces on children’s health; availability, accessibility, type, safety, and social infrastructures should be considered in developing child-centered and nutrition-sensitive green spaces. We recommend that a green space policy should follow a wider multi-sectoral and systems-based approach by considering social, urban planning, financial, educational, and environmental interventions to holistically prevent childhood obesity in the country’s socioeconomically deprived urban communities.
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- 2022
- Full Text
- View/download PDF
49. Partners in Catholic Education: Pastor, Professional, Parent. A Workbook for Leaders in Catholic Education.
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National Catholic Educational Association, Washington, DC., Hughes, Jane Wolford, and Barnds, Mary Lynch
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Since the Vatican Council II, communities of the Catholic Church have accepted a in the modern world. With radical changes taking place in society, the introduction of the theme of interdependence by Pope John XXIII was both timely and prophetic. The evolution to a more collaborative church organizational style does not imply the elimination of authority, but a more discerning use of authority. The first of three sections comprising this document describes the present situation and outlines: the establishment of a common language; perceptions of organizational style, roles, and partnerships; and the external and internal influences that impact educational effort. The second section is devoted to analyzing organizational style, roles and relationships, and external and internal influences. The third section contains a guide to developing workable strategies for future planning. Background reading on change, partnership/collaboration, community, and values is also provided. (KM)
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- 1989
50. User-centered design and agile development of a novel mobile health application and clinician dashboard to support the collection and reporting of patient-reported outcomes for breast cancer care
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Elena Tsangaris, Maria Edelen, Jessica Means, Madelijn Gregorowitsch, Joanna O’Gorman, Rakasa Pattanaik, Laura Dominici, Michael Hassett, Mary Lynch Witkowski, Kristen Schrieber, Elizabeth Frank, Martha Carnie, and Andrea Pusic
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Biomedical Engineering ,Surgery - Abstract
ObjectivesThere is a need for advancements in health information technology that will transform how patient-reported outcomes (PRO) data are collected, reported, and used in breast cancer care. The objective of this study was to develop an innovative and customizable platform, called imPROVE to support PRO uptake in breast cancer care.DesignUser-centered design and agile development were employed. Recurrent stakeholder meetings with experts in the field of breast cancer care, in-depth one-on-one qualitative interviews with a clinical sample of patients with breast cancer, and focus groups with Dana-Farber/Harvard Cancer Center (DF/HCC) Breast Cancer Advisory Group members, were used to elicit feedback for the design features and functions of a patient mobile application and clinician dashboard.SettingThis study was conducted at two academic hospitals in the USA.ParticipantsParticipants included experts in the field of breast cancer care, value-based healthcare, and health information technology, a clinical sample of patients with breast cancer, and members of the DF/HCC Breast Cancer Advisory Group.Main outcome measuresimPROVE incorporates the International Consortium for Health Outcomes Measurement (ICHOM) breast cancer standard outcome set as well as the complete BREAST-Q Breast Cancer Module.ResultsFeedback was elicited from eight stakeholder meetings (n=28 members), interviews with a clinical sample of patients (n=28), and two focus groups with members of the DF/HCC Breast Cancer Advisory Group (n=17 members in each focus group). Participant feedback led to the development of a patient mobile application consisting of five components (myCare, myStory, myResources, myCommunity, and myNotes) and a clinician dashboard that includes an overview table and individual patient profiles with data displays.ConclusionsimPROVE has the potential to transform the way we deliver care to patients. Developed from best practices in user-centered design, agile development, and qualitative methods; imPROVE addresses the needs of multiple stakeholders, including patients, clinicians, healthcare administrators, and researchers.
- Published
- 2021
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