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12 results on '"Mary C. Beytagh"'

1. Figure S1 from BRG1 Loss Predisposes Lung Cancers to Replicative Stress and ATR Dependency

Author

Carla F. Kim, Tyler Jacks, Steven A. Carr, Lee Zou, Kwok-Kin Wong, Aaron N. Hata, Alice T. Shaw, Roderick T. Bronson, Angeliki Karatza, Hai Hu, Fei Li, Audris Oh, Chendi Li, D.R. Mani, Monica Schenone, Caroline R. Stanclift, Mary C. Beytagh, Margherita Paschini, Antoine Simoneau, Jonathan Y. Kim, Patrizia Pessina, Francisco J. Sanchez-Rivera, Christine F. Brainson, Arjun Bhutkar, Hasmik Keshishian, Caroline G. Fahey, Carla P. Concepcion, and Manav Gupta

Abstract

Figure S1 shows detailed RNA-sequencing analysis of patient samples as well as murine isogenic cell lines. Also presented here is further characterization of human isogenic models of BRG1 loss.

Published
2023

2. Figure S2 from BRG1 Loss Predisposes Lung Cancers to Replicative Stress and ATR Dependency

Author

Carla F. Kim, Tyler Jacks, Steven A. Carr, Lee Zou, Kwok-Kin Wong, Aaron N. Hata, Alice T. Shaw, Roderick T. Bronson, Angeliki Karatza, Hai Hu, Fei Li, Audris Oh, Chendi Li, D.R. Mani, Monica Schenone, Caroline R. Stanclift, Mary C. Beytagh, Margherita Paschini, Antoine Simoneau, Jonathan Y. Kim, Patrizia Pessina, Francisco J. Sanchez-Rivera, Christine F. Brainson, Arjun Bhutkar, Hasmik Keshishian, Caroline G. Fahey, Carla P. Concepcion, and Manav Gupta

Abstract

Figure S2 shows proliferation, cell cycle, and replication fork related changes in human isogenic models of BRG1 loss.

Published
2023

3. Supplementary Table 1 from BRG1 Loss Predisposes Lung Cancers to Replicative Stress and ATR Dependency

Author

Carla F. Kim, Tyler Jacks, Steven A. Carr, Lee Zou, Kwok-Kin Wong, Aaron N. Hata, Alice T. Shaw, Roderick T. Bronson, Angeliki Karatza, Hai Hu, Fei Li, Audris Oh, Chendi Li, D.R. Mani, Monica Schenone, Caroline R. Stanclift, Mary C. Beytagh, Margherita Paschini, Antoine Simoneau, Jonathan Y. Kim, Patrizia Pessina, Francisco J. Sanchez-Rivera, Christine F. Brainson, Arjun Bhutkar, Hasmik Keshishian, Caroline G. Fahey, Carla P. Concepcion, and Manav Gupta

Abstract

Differential RNA-seq analysis and list of all gene ontology and cancer reactome pathways found for top differentially upregulated genes in BRG1 mutant lung cancer patients compared to BRG1 wildtype patients, in the TCGA, PanCancer databases.

Published
2023

4. Figure S5 from BRG1 Loss Predisposes Lung Cancers to Replicative Stress and ATR Dependency

Author

Carla F. Kim, Tyler Jacks, Steven A. Carr, Lee Zou, Kwok-Kin Wong, Aaron N. Hata, Alice T. Shaw, Roderick T. Bronson, Angeliki Karatza, Hai Hu, Fei Li, Audris Oh, Chendi Li, D.R. Mani, Monica Schenone, Caroline R. Stanclift, Mary C. Beytagh, Margherita Paschini, Antoine Simoneau, Jonathan Y. Kim, Patrizia Pessina, Francisco J. Sanchez-Rivera, Christine F. Brainson, Arjun Bhutkar, Hasmik Keshishian, Caroline G. Fahey, Carla P. Concepcion, and Manav Gupta

Abstract

Figure S5 provides details about drug screens in H2009 cells, along with further in vitro and in vivo characterization of ATR inhibition responses in lung cancers with BRG1 mutations or loss.

Published
2023

5. Figure legends for supplementary figures from BRG1 Loss Predisposes Lung Cancers to Replicative Stress and ATR Dependency

Author

Carla F. Kim, Tyler Jacks, Steven A. Carr, Lee Zou, Kwok-Kin Wong, Aaron N. Hata, Alice T. Shaw, Roderick T. Bronson, Angeliki Karatza, Hai Hu, Fei Li, Audris Oh, Chendi Li, D.R. Mani, Monica Schenone, Caroline R. Stanclift, Mary C. Beytagh, Margherita Paschini, Antoine Simoneau, Jonathan Y. Kim, Patrizia Pessina, Francisco J. Sanchez-Rivera, Christine F. Brainson, Arjun Bhutkar, Hasmik Keshishian, Caroline G. Fahey, Carla P. Concepcion, and Manav Gupta

Abstract

All figure legends for supplementary figures included here.

Published
2023

6. Supplementary Table 5 from BRG1 Loss Predisposes Lung Cancers to Replicative Stress and ATR Dependency

Author

Carla F. Kim, Tyler Jacks, Steven A. Carr, Lee Zou, Kwok-Kin Wong, Aaron N. Hata, Alice T. Shaw, Roderick T. Bronson, Angeliki Karatza, Hai Hu, Fei Li, Audris Oh, Chendi Li, D.R. Mani, Monica Schenone, Caroline R. Stanclift, Mary C. Beytagh, Margherita Paschini, Antoine Simoneau, Jonathan Y. Kim, Patrizia Pessina, Francisco J. Sanchez-Rivera, Christine F. Brainson, Arjun Bhutkar, Hasmik Keshishian, Caroline G. Fahey, Carla P. Concepcion, and Manav Gupta

Abstract

Cancer dependency analysis in pan cancer datasets - DRIVE and ACHILLES.

Published
2023

7. Supplementary Table 2 from BRG1 Loss Predisposes Lung Cancers to Replicative Stress and ATR Dependency

Author

Carla F. Kim, Tyler Jacks, Steven A. Carr, Lee Zou, Kwok-Kin Wong, Aaron N. Hata, Alice T. Shaw, Roderick T. Bronson, Angeliki Karatza, Hai Hu, Fei Li, Audris Oh, Chendi Li, D.R. Mani, Monica Schenone, Caroline R. Stanclift, Mary C. Beytagh, Margherita Paschini, Antoine Simoneau, Jonathan Y. Kim, Patrizia Pessina, Francisco J. Sanchez-Rivera, Christine F. Brainson, Arjun Bhutkar, Hasmik Keshishian, Caroline G. Fahey, Carla P. Concepcion, and Manav Gupta

Abstract

Differential RNA-seq analysis and list of all gene ontology and cancer reactome pathways found for top differentially upregulated genes in isogenic murine Brg1 knockout lung cancer cells compared to Brg1 wildtype cells.

Published
2023

8. Titles for supplementary tables from BRG1 Loss Predisposes Lung Cancers to Replicative Stress and ATR Dependency

Author

Carla F. Kim, Tyler Jacks, Steven A. Carr, Lee Zou, Kwok-Kin Wong, Aaron N. Hata, Alice T. Shaw, Roderick T. Bronson, Angeliki Karatza, Hai Hu, Fei Li, Audris Oh, Chendi Li, D.R. Mani, Monica Schenone, Caroline R. Stanclift, Mary C. Beytagh, Margherita Paschini, Antoine Simoneau, Jonathan Y. Kim, Patrizia Pessina, Francisco J. Sanchez-Rivera, Christine F. Brainson, Arjun Bhutkar, Hasmik Keshishian, Caroline G. Fahey, Carla P. Concepcion, and Manav Gupta

Abstract

All titles for supplementary tables included here.

Published
2023

9. Supplementary Table 4 from BRG1 Loss Predisposes Lung Cancers to Replicative Stress and ATR Dependency

Author

Carla F. Kim, Tyler Jacks, Steven A. Carr, Lee Zou, Kwok-Kin Wong, Aaron N. Hata, Alice T. Shaw, Roderick T. Bronson, Angeliki Karatza, Hai Hu, Fei Li, Audris Oh, Chendi Li, D.R. Mani, Monica Schenone, Caroline R. Stanclift, Mary C. Beytagh, Margherita Paschini, Antoine Simoneau, Jonathan Y. Kim, Patrizia Pessina, Francisco J. Sanchez-Rivera, Christine F. Brainson, Arjun Bhutkar, Hasmik Keshishian, Caroline G. Fahey, Carla P. Concepcion, and Manav Gupta

Abstract

Mass spectrometry-based enrichment of proteins quantified using Baf47 interaction in isogenic Brg1 wildtype and knockout cells. List includes details about identification and quantitation of proteins and is sorted by logFC.

Published
2023

10. Figure S4 from BRG1 Loss Predisposes Lung Cancers to Replicative Stress and ATR Dependency

Author

Carla F. Kim, Tyler Jacks, Steven A. Carr, Lee Zou, Kwok-Kin Wong, Aaron N. Hata, Alice T. Shaw, Roderick T. Bronson, Angeliki Karatza, Hai Hu, Fei Li, Audris Oh, Chendi Li, D.R. Mani, Monica Schenone, Caroline R. Stanclift, Mary C. Beytagh, Margherita Paschini, Antoine Simoneau, Jonathan Y. Kim, Patrizia Pessina, Francisco J. Sanchez-Rivera, Christine F. Brainson, Arjun Bhutkar, Hasmik Keshishian, Caroline G. Fahey, Carla P. Concepcion, and Manav Gupta

Abstract

Figure S4 provides further mass spectrometry analysis and co-immunoprecipitation experiments for BRG1 in several human isogenic models of BRG1 loss.

Published
2023

11. Figure S3 from BRG1 Loss Predisposes Lung Cancers to Replicative Stress and ATR Dependency

Author

Carla F. Kim, Tyler Jacks, Steven A. Carr, Lee Zou, Kwok-Kin Wong, Aaron N. Hata, Alice T. Shaw, Roderick T. Bronson, Angeliki Karatza, Hai Hu, Fei Li, Audris Oh, Chendi Li, D.R. Mani, Monica Schenone, Caroline R. Stanclift, Mary C. Beytagh, Margherita Paschini, Antoine Simoneau, Jonathan Y. Kim, Patrizia Pessina, Francisco J. Sanchez-Rivera, Christine F. Brainson, Arjun Bhutkar, Hasmik Keshishian, Caroline G. Fahey, Carla P. Concepcion, and Manav Gupta

Abstract

Figure S3 provides further detail about DNA fibers analysis and increased CDC6 and pre-replication signatures in BRG1-mutant lung cancers.

Published
2023

12. Abstract P023: Mismatch repair deficiency is not sufficient to increase tumor immunogenicity

Author

Peter M. K. Westcott, Francesc M. Remolar, Olivia Smith, Haley Hauck, Nathan J. Sacks, Zackery A. Ely, Alex M. Jaeger, William M. Rideout, Arjun Bhutkar, Daniel Zhang, Mary C. Beytagh, Roderick T. Bronson, David A. Canner, Santiago Naranjo, Abbey Jin, J. J. Patten, Amanda M. Cruz, Isidro Cortes-Ciriano, and Tyler Jacks

Subjects
Cancer Research, Immunology
Abstract

Deficient DNA mismatch repair (dMMR) in human cancer is associated with high tumor mutation burden (TMB), frameshift mutation-derived neoantigens, increased T cell infiltration, and remarkable responsiveness to immune checkpoint blockade (ICB) therapy. Nevertheless, about half of these tumors do not respond to ICB for unclear reasons. While tumor cell line transplant models of dMMR have helped solidify the importance of TMB in immune response, critical questions remain regarding the role of immune surveillance in the evolution of dMMR tumors induced in vivo. Here, we developed autochthonous mouse models of lung and colon cancer with highly efficient ablation of MMR genes via in vivo CRISPR/Cas9 targeting. Surprisingly, dMMR in these models did not result in increased immunogenicity or response to ICB, which we showed is driven by profound intratumoral heterogeneity. Studies in animals depleted of T cells further demonstrated that immune surveillance in dMMR tumors has no impact on TMB but shapes the clonal architecture of neoantigens. These results provide important context for understanding immune evasion in cancers with high TMB and have major implications for therapies aimed at increasing TMB. Citation Format: Peter M. K. Westcott, Francesc M. Remolar, Olivia Smith, Haley Hauck, Nathan J. Sacks, Zackery A. Ely, Alex M. Jaeger, William M. Rideout, Arjun Bhutkar, Daniel Zhang, Mary C. Beytagh, Roderick T. Bronson, David A. Canner, Santiago Naranjo, Abbey Jin, J. J. Patten, Amanda M. Cruz, Isidro Cortes-Ciriano, Tyler Jacks. Mismatch repair deficiency is not sufficient to increase tumor immunogenicity [abstract]. In: Abstracts: AACR Virtual Special Conference: Tumor Immunology and Immunotherapy; 2021 Oct 5-6. Philadelphia (PA): AACR; Cancer Immunol Res 2022;10(1 Suppl):Abstract nr P023.

Published
2022

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