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3. Local application of platelet-activating factor induces cervical ripening accompanied by infiltration of polymorphonuclear leukocytes in rats

Author

Maul, Holger, Shi, Leili, Marx, Stephen G., Garfield, Robert E., and Saade, George R.

Subjects
Labor (Obstetrics) -- Physiological aspects, Platelet activating factor -- Physiological aspects, Health
Abstract

Platelet-activating factor may play a role in cervical ripening, according to a study in pregnant rats. Cervical ripening is the medical term for the process the cervix goes through during labor. Normally, the cervix is tight and closed, but it must become soft and pliable during childbirth so it can open and allow the baby to pass through the birth canal. Platelet-activating factor caused cervical ripening when applied to the cervixes of the rats.

Published
2002

6. Neurokinin B peptide serum levels are higher in normotensive pregnant women than in preeclamptic pregnant women.

Author

Schlembacht, Dietmar, Scalera, Fortunato, Fischer, Tina, Marx, Stephen G., Beinder, Ernst, and Garfield, Robert E.

Subjects
PREECLAMPSIA, TACHYKININS, OBSTETRICS
Abstract

OBJECTIVES: The purpose of this study was to examine neurokinin B levels in serum from preeclamptic and normotensive and to investigate the role of neurokinin B in preeclampsia. STUDY DESIGN: Peripheral and uterine venous blood neurokinin B levels were measured in 14 normotensive and 8 preeclamptic pregnant women by radioimmunoassay. RESULTS: Neurokinin B levels in normotensive women were 4.91 ± 2.67 nmol/L in peripheral and 5.59 ± 2.06 nmol/L in uterine blood. In pregnant women with preeclampsia, neurokinin B levels were 2.79 ± 1.68 nmol/L and 3.20 ± 1.55 nmol/L, respectively. Neurokinin B levels were significantly higher in normotensive women (P = .032 in peripheral and P = .006 in uterine blood). CONCLUSIONS: Neurokinin B serum levels were higher in normotensive women. Higher neurokinin B concentrations in normotensive pregnant women may be due to the advanced gestational age and/or the result of a negative interaction of other vasoactive substances. The role of neurokinin B in preeclampsia remains to be determined. [ABSTRACT FROM AUTHOR]

Published
2003
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