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3 results on '"Marwa E. Atya"'

1. Kinetic behavior of the network structure changes in funoran gelation studied by rheological and NMR measurements

Author

Marwa E. Atya, Rando Tuvikene, and Shingo Matsukawa

Subjects
Funoran, Kinetic, Gelation, Theoretical model, Helix length, Biochemistry, QD415-436
Abstract

Funoran is a promising food polysaccharide with unique gelling properties but understanding its gelation behaviors remains inadequate. This study aimed to investigate the influence of cooling and heating rates on funoran gelation properties and study its gelation mechanism by dynamic rheology and NMR studies. With constant heating rates, the melting point was unaffected by changing cooling rates, whereas higher cooling and heating rates enhance the gel strength and thermal hysteresis. The gelation kinetics mechanism of the funoran solution was elucidated at different quenching temperatures. The rheological measurement results indicated that the funoran solution quenched to lower temperatures resulted in higher G` in the gel state, and faster gelation rate compared with the solution quenched at higher temperatures. 1H NMR results revealed a slow decay in funoran signal intensity at higher temperatures (20 °C) and a fast signal decay at 2 °C. A theoretical model involving second and first-order reactions was proposed to describe the gelation kinetic process of funoran at different quenching temperatures. It was shown longer helix lengths were required for stable intermolecular association and gel formation at higher temperatures than at lower temperatures. These results offer valuable insights for optimizing the funoran gelation properties for various food applications.

Published
2024
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2. In vitro biological activities and in vivo hepatoprotective role of brown algae-isolated fucoidans

Author

Mohamed M. El-Sadek, Mohamed A. Aly-Eldeen, Amr El-Hawiet, Mohamed M. Abdel-Daim, Marwa E. Atya, and Doaa A. Ghareeb

Subjects
chemistry.chemical_classification, Antioxidant, Fucoidan, Health, Toxicology and Mutagenesis, Glutathione peroxidase, medicine.medical_treatment, General Medicine, Glutathione, 010501 environmental sciences, Pharmacology, Malondialdehyde, 01 natural sciences, Pollution, chemistry.chemical_compound, chemistry, In vivo, medicine, Environmental Chemistry, Colpomenia sinuosa, Liver function, 0105 earth and related environmental sciences
Abstract

Brown seaweeds are rich in polysaccharides, such as fucoidan (FUC) which has shown beneficial effects in several medical conditions. The aim of the present study was to assess the antioxidant, anti-inflammatory, and hepatoprotective properties of Colpomenia sinuosa– and Sargassum prismaticum–isolated FUC in vitro and in vivo. The hot acid extraction method was used to isolate FUC from C. sinuosa (FCS) and S. prismaticum (FSP) species. The antioxidant, anticancer, as well as the effect on neurotransmitter-degrading enzyme and disaccharidase activities were measured using standard protocols. Moreover, the hepatoprotective effect of two FCS doses (100 and 200 mg/kg) on paracetamol-administered rats (one dose of 1 g/kg) were evaluated by measuring blood liver function markers, hepatic pro-oxidants as malondialdehyde (MDA) and nitric oxide (NO), antioxidants as glutathione (GSH) and glutathione peroxidase (GPx), proinflammatory markers as inducible nitric oxide synthase (iNOS), interleukin 1β (IL-1β), tumor necrosis factor-α (TNF-α), and liver histology. The crude fucoidan yield was 15.6% and 14.8% of C. sinuosa and S. prismaticum dry weights, respectively. The antioxidant effects and cytotoxic activity on hepatic cancer cell were higher for FCS than FSP. Moreover, in vivo data showed that FCS administration at both doses significantly improved liver functions and alleviated histological alterations, hepatic inflammation, and oxidative stress following paracetamol intake. In conclusion, fucoidan exerts anti-inflammatory, antidigestive enzyme activity, antioxidant, anticancer, and hepatoprotective effects.

Published
2021

3. In vitro biological activities and in vivo hepatoprotective role of brown algae-isolated fucoidans

Author

Marwa E, Atya, Amr, El-Hawiet, Mohamed A, Alyeldeen, Doaa A, Ghareeb, Mohamed M, Abdel-Daim, and Mohamed M, El-Sadek

Subjects
Oxidative Stress, Liver, Polysaccharides, Animals, Phaeophyta, Antioxidants, Rats
Abstract

Brown seaweeds are rich in polysaccharides, such as fucoidan (FUC) which has shown beneficial effects in several medical conditions. The aim of the present study was to assess the antioxidant, anti-inflammatory, and hepatoprotective properties of Colpomenia sinuosa- and Sargassum prismaticum-isolated FUC in vitro and in vivo. The hot acid extraction method was used to isolate FUC from C. sinuosa (FCS) and S. prismaticum (FSP) species. The antioxidant, anticancer, as well as the effect on neurotransmitter-degrading enzyme and disaccharidase activities were measured using standard protocols. Moreover, the hepatoprotective effect of two FCS doses (100 and 200 mg/kg) on paracetamol-administered rats (one dose of 1 g/kg) were evaluated by measuring blood liver function markers, hepatic pro-oxidants as malondialdehyde (MDA) and nitric oxide (NO), antioxidants as glutathione (GSH) and glutathione peroxidase (GPx), proinflammatory markers as inducible nitric oxide synthase (iNOS), interleukin 1β (IL-1β), tumor necrosis factor-α (TNF-α), and liver histology. The crude fucoidan yield was 15.6% and 14.8% of C. sinuosa and S. prismaticum dry weights, respectively. The antioxidant effects and cytotoxic activity on hepatic cancer cell were higher for FCS than FSP. Moreover, in vivo data showed that FCS administration at both doses significantly improved liver functions and alleviated histological alterations, hepatic inflammation, and oxidative stress following paracetamol intake. In conclusion, fucoidan exerts anti-inflammatory, antidigestive enzyme activity, antioxidant, anticancer, and hepatoprotective effects.

Published
2020

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