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2 results on '"Marwa A. Bebars"'

1. Kawasaki disease (KD) and multisystem inflammatory syndrome in children (MIS-C) in a Middle Eastern patient cohort

Author

Lemis Yavuz, Sarmad AlHamdani, Samah Alasrawi, Deena Wafadari, Ali Al-Fraihat, Marwa A. Bebars, Jaidev Nath, Diego Arango, Marco Pallavidino, Ruchi Jain, Sinan Yavuz, Mohamed AlAwadhi, Abdulla Alkhayat, Ahmad Abou Tayoun, and Walid Mohammad Abuhammour

Subjects
KD, MIS-C, Pediatrics, Fever in children, Inflammatory disease, COVID-19, RJ1-570, Diseases of the musculoskeletal system, RC925-935
Abstract

Abstract Objective This is a comprehensive characteristic study of Kawasaki disease (KD) and Multi system inflammatory syndrome in children (MIS-C) in the Middle East that creates a formula to differentiate between the two. Methods We conducted a descriptive comparative study of KD and MIS-C in the United Arab Emirates. Retrospective MIS-C and KD cohorts were recruited between January 2017 until August 2021.We compared clinical and laboratory characteristics between both groups. Our data were compared with 87 patients with KD or MIS-C from the literature. Results We report on123 patients. Sixty-seven (54%) met the criteria for KD (36 male, 43 Arab), and fifty-six (46%) met the criteria for MIS-C (28 male, 35 Arab). The median age was 2.2 years range (0.15–10.7) in the KD group and 7.3 years (0.7–15.2) in the MIS-C group (P

Published
2023
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2. Tissue factor expression predicts outcome in children with neuroblastoma: A retrospective study

Author

Elia A. Eshak, Marwa A. Bebars, Tamer Hassan, Asmaa Esh, Marwa Zakaria, Manar Fathy, and Laila M. Sherief

Subjects
0301 basic medicine, Cancer Research, Oncogene, business.industry, Angiogenesis, Cancer, Articles, medicine.disease, tissue factor, Molecular medicine, Metastasis, 03 medical and health sciences, Tissue factor, neuroblastoma, 030104 developmental biology, 0302 clinical medicine, Oncology, 030220 oncology & carcinogenesis, Neuroblastoma, expression, Cancer research, outcome, Medicine, Immunohistochemistry, business
Abstract

Previous studies have revealed that the processes of tumor angiogenesis, metastasis and invasiveness are highly dependent on components of the blood coagulation cascade. Tissue factor (TF) is one of the key proteins in coagulation. Cumulative evidence suggested that in addition to its role in coagulation, TF regulates intracellular signaling pathways that serve an important role in angiogenesis, tumor development and metastasis. In the present study, TF expression in neuroblastoma as well as its association with tumor stage, pathology and outcome were assessed. A total of 40 formalin-fixed paraffin-embedded tissues were evaluated for TF expression by immunohistochemical analysis. Results revealed that TF expression was positive in 75% of the analyzed tumor tissues. No significant association between TF expression and sex, age, tumor stage or disease pathology was observed. MYCN proto-oncogene bHLH transcription factor (MYCN) was upregulated in 45% (n=18) of the study cases. Positive TF expression was observed in 94.4% of patients (n=17) with upregulated MYCN, while 59% of patients (n=13) with normal MYCN showed positive TF expression (P

Published
2019

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