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25 results on '"Maruyama, Sandra Regina"'

1. Parasite detection in visceral leishmaniasis samples by dye-based qPCR using new gene targets of 'Leishmania infantum' and 'Crithidia'

Author

Takamiya, Nayore Tamie, Rogerio, Luana Aparecida, Torres, Caroline, Leonel, Joao Augusto Franco, Vioti, Geovanna, Oliveira, Tricia Maria Ferreira de Sousa, Valeriano, Karoline Camila, Porcino, Gabriane Nascimento, Santos, Isabel Kinney Ferreira de Miranda, Costa, Carlos HN, Costa, Dorcas Lamounier, Ferreira, Tauana Sousa, Gurgel-Goncalves, Rodrigo, da Silva, Joao Santana, Teixeira, Felipe Roberti, De Almeida, Roque Pacheco, Ribeiro, Jose MC, and Maruyama, Sandra Regina

Published
2023

3. Leukocyte dysfunction and reduced CTLA-4 expression are associated with perianal Crohn's disease.

Author

Duarte-Silva, Murillo, Parra, Rogério Serafim, Feitosa, Marley Ribeiro, Nardini, Viviani, Maruyama, Sandra Regina, da Rocha, José Joaquim Ribeiro, Feres, Omar, and de Barros Cardoso, Cristina Ribeiro

Subjects
MONONUCLEAR leukocytes, CROHN'S disease, INFLAMMATORY bowel diseases, TUMOR necrosis factors, CYTOTOXIC T lymphocyte-associated molecule-4
Abstract

Although perianal Crohn's disease (PCD) is highly associated with the exacerbated inflammation, the molecular basis and immunological signature that distinguish patients who present a history of perianal lesions are still unclear. This paper aims to define immunological characteristics related to PCD. In this cross-sectional observational study, we enrolled 20 healthy controls and 39 CD patients. Blood samples were obtained for the detection of plasma cytokines and lipopolysaccharides (LPS). Peripheral blood mononuclear cells (PBMCs) were phenotyped by flow cytometry. Leukocytes were stimulated with LPS or anti-CD3/anti-CD28 antibodies. Our results show that CD patients had augmented plasma interleukin (IL)-6 and LPS. However, their PBMC was characterized by decreased IL-6 production, while patients with a history of PCD produced higher IL-6, IL-8, and interferon-γ, along with decreased tumor necrosis factor alpha (TNF). CD patients had augmented FoxP3 and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) regulatory markers, though the PCD subjects presented a significant reduction in CTLA-4 expression. CTLA-4 as well as IL-6 and TNF responses were able to distinguish the PCD patients from those who did not present perianal complications. In conclusion, IL-6, TNF, and CTLA-4 exhibit a distinct expression pattern in CD patients with a history of PCD, regardless of disease activity. These findings clarify some mechanisms involved in the development of the perianal manifestations and may have a great impact on the disease management. Although perianal Crohn's disease (PCD) is highly associated with the exacerbated inflammation, the molecular basis and immunological signature that distinguish patients who present a history of perianal lesions are still unclear. This paper aims to define immunological characteristics related to PCD. These findings clarify some mechanisms involved in the development of the perianal manifestations and may have a great impact on the disease management. Graphical Abstract [ABSTRACT FROM AUTHOR]

Published
2024
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6. Co-infection of Leishmania infantum and a Crithidia-related species in a case of refractory relapsed visceral leishmaniasis with non-ulcerated cutaneous manifestation in Brazil

Author

Rogerio, Luana Aparecida, primary, Takahashi, Talita Yuri, additional, Cardoso, Luria, additional, Takamiya, Nayore Tamie, additional, de Melo, Enaldo Vieira, additional, de Jesus, Amelia Ribeiro, additional, de Oliveira, Fabricia Alvisi, additional, Forrester, Sarah, additional, Jeffares, Daniel C., additional, da Silva, João Santana, additional, Ribeiro, José Marcos, additional, Almeida, Roque Pacheco, additional, and Maruyama, Sandra Regina, additional

Published
2023
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8. Insight Into the Long Noncoding RNA and mRNA Coexpression Profile in the Human Blood Transcriptome Upon Leishmania infantum Infection

Author

Maruyama, Sandra Regina, primary, Fuzo, Carlos Alessandro, additional, Oliveira, Antonio Edson R., additional, Rogerio, Luana Aparecida, additional, Takamiya, Nayore Tamie, additional, Pessenda, Gabriela, additional, de Melo, Enaldo Vieira, additional, da Silva, Angela Maria, additional, Jesus, Amélia Ribeiro, additional, Carregaro, Vanessa, additional, Nakaya, Helder I., additional, Almeida, Roque Pacheco, additional, and da Silva, João Santana, additional

Published
2022
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11. COVID-19: Integrating the Complexity of Systemic and Pulmonary Immunopathology to Identify Biomarkers for Different Outcomes

Author

Fraga-Silva, Thais Fernanda de Campos, primary, Maruyama, Sandra Regina, additional, Sorgi, Carlos Arterio, additional, Russo, Elisa Maria de Sousa, additional, Fernandes, Ana Paula Morais, additional, de Barros Cardoso, Cristina Ribeiro, additional, Faccioli, Lucia Helena, additional, Dias-Baruffi, Marcelo, additional, and Bonato, Vânia Luiza Deperon, additional

Published
2021
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12. TLR4 abrogates the Th1 immune response through IRF1 and IFN-β to prevent immunopathology during L. infantum infection

Author

Sacramento, Laís Amorim, primary, Benevides, Luciana, additional, Maruyama, Sandra Regina, additional, Tavares, Lucas, additional, Fukutani, Kiyoshi Ferreira, additional, Francozo, Marcela, additional, Sparwasser, Tim, additional, Cunha, Fernando Queiroz, additional, Almeida, Roque Pacheco, additional, da Silva, João Santana, additional, and Carregaro, Vanessa, additional

Published
2020
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13. From Chromosomes to Genome: Insights into the Evolutionary Relationships and Biogeography of Old World Knifefishes (Notopteridae

Author

Barby, Felipe Faix, Ráb, Petr, Lavoué, Sébastien, Ezaz, Tariq, Bertollo, Luiz Antônio Carlos, Kilian, Andrzej, Maruyama, Sandra Regina, Oliveira, Ezequiel Aguiar de, Artoni, Roberto Ferreira, Santos, Mateus Henrique, Jegede, Oladele Ilesanmi, Hatanaka, Terumi, Tanomtong, Alongklod, Liehr, Thomas, and Cioffi, Marcelo de Bello

Subjects
Out-of-India, fluorescent in situ hybridization (FISH), Notopteridae, DArTseq NGS, Lemurian stepping-stones, chromosomal evolution, Osteoglossiformes
Abstract

In addition to its wide geographical distribution, osteoglossiform fishes represent one of the most ancient freshwater teleost lineages, making it an important group for systematic and evolutionary studies. These fishes had a Gondwanan origin and their past distribution may have contributed to the diversity present in this group. However, cytogenetic and genomic data are still scarce, making it difficult to track evolutionary trajectories within this order. In addition, their wide distribution, with groups endemic to different continents, hinders an integrative study that allows a globalized view of its evolutionary process. Here, we performed a detailed chromosomal analysis in Notopteridae fishes, using conventional and advanced molecular cytogenetic methods. Moreover, the genetic distances of examined species were assessed by genotyping using diversity arrays technology sequencing (DArTseq). These data provided a clear picture of the genetic diversity between African and Asian Notopteridae species, and were highly consistent with the chromosomal, geographical, and historical data, enlightening their evolutionary diversification. Here, we discuss the impact of continental drift and split of Pangea on their recent diversity, as well as the contribution to biogeographical models that explain their distribution, highlighting the role of the Indian subcontinent in the evolutionary process within the family.

Published
2018
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14. Cytogenetics, genomics and biodiversity of the South American and African Arapaimidae fish family (Teleostei, Osteoglossiformes)

Author

de Oliveira, Ezequiel Aguiar, primary, Bertollo, Luiz Antonio Carlos, additional, Rab, Petr, additional, Ezaz, Tariq, additional, Yano, Cassia Fernanda, additional, Hatanaka, Terumi, additional, Jegede, Oladele Ilesanmi, additional, Tanomtong, Alongklod, additional, Liehr, Thomas, additional, Sember, Alexandr, additional, Maruyama, Sandra Regina, additional, Feldberg, Eliana, additional, Viana, Patrik Ferreira, additional, and Cioffi, Marcelo de Bello, additional

Published
2019
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15. Immune recognition of salivary proteins from the cattle tick Rhipicephalus microplus differs according to the genotype of the bovine host

Author

Garcia, Gustavo Rocha, Maruyama, Sandra Regina, Nelson, Kristina T, Ribeiro, José Marcos Chaves, Gardinassi, Luiz Gustavo, Maia, Antonio Augusto Mendes, Ferreira, Beatriz Rossetti, Kooyman, Frans N J, de Miranda Santos, Isabel K F, Garcia, Gustavo Rocha, Maruyama, Sandra Regina, Nelson, Kristina T, Ribeiro, José Marcos Chaves, Gardinassi, Luiz Gustavo, Maia, Antonio Augusto Mendes, Ferreira, Beatriz Rossetti, Kooyman, Frans N J, and de Miranda Santos, Isabel K F

Abstract

BACKGROUND: Males of the cattle tick Rhipicephalus microplus produce salivary immunoglobulin-binding proteins and allotypic variations in IgG are associated with tick loads in bovines. These findings indicate that antibody responses may be essential to control tick infestations. Infestation loads with cattle ticks are heritable: some breeds carry high loads of reproductively successful ticks, in others, few ticks feed and they reproduce inefficiently. Different patterns of humoral immunity against tick salivary proteins may explain these phenotypes.METHODS: We describe the profiles of humoral responses against tick salivary proteins elicited during repeated artificial infestations of bovines of a tick-resistant (Nelore) and a tick-susceptible (Holstein) breed. We measured serum levels of total IgG1, IgG2 and IgE immunoglobulins and of IgG1 and IgG2 antibodies specific for tick salivary proteins. With liquid chromatography followed by mass spectrometry we identified tick salivary proteins that were differentially recognized by serum antibodies from tick-resistant and tick-susceptible bovines in immunoblots of tick salivary proteins separated by two-dimensional electrophoresis.RESULTS: Baseline levels of total IgG1 and IgG2 were significantly higher in tick-susceptible Holsteins compared with resistant Nelores. Significant increases in levels of total IgG1, but not of IgG2 accompanied successive infestations in both breeds. Resistant Nelores presented with significantly higher levels of salivary-specific antibodies before and at the first challenge with tick larvae; however, by the third challenge, tick-susceptible Holsteins presented with significantly higher levels of IgG1 and IgG2 tick salivary protein-specific antibodies. Importantly, sera from tick-resistant Nelores reacted with 39 tick salivary proteins in immunoblots of salivary proteins separated in two dimensions by electrophoresis versus only 21 spots reacting with sera from tick-susceptible

Published
2017

16. Immune recognition of salivary proteins from the cattle tick Rhipicephalus microplus differs according to the genotype of the bovine host

Author

dI&I I&I-4, Garcia, Gustavo Rocha, Maruyama, Sandra Regina, Nelson, Kristina T, Ribeiro, José Marcos Chaves, Gardinassi, Luiz Gustavo, Maia, Antonio Augusto Mendes, Ferreira, Beatriz Rossetti, Kooyman, Frans N J, de Miranda Santos, Isabel K F, dI&I I&I-4, Garcia, Gustavo Rocha, Maruyama, Sandra Regina, Nelson, Kristina T, Ribeiro, José Marcos Chaves, Gardinassi, Luiz Gustavo, Maia, Antonio Augusto Mendes, Ferreira, Beatriz Rossetti, Kooyman, Frans N J, and de Miranda Santos, Isabel K F

Published
2017

17. Immune recognition of salivary proteins from the cattle tick Rhipicephalus microplus differs according to the genotype of the bovine host

Author

Garcia, Gustavo Rocha, Maruyama, Sandra Regina, Nelson, Kristina T, Ribeiro, José Marcos Chaves, Gardinassi, Luiz Gustavo, Maia, Antonio Augusto Mendes, Ferreira, Beatriz Rossetti, Kooyman, Frans N J, de Miranda Santos, Isabel K F, dI&I I&I-4, and dI&I I&I-4

Subjects
0301 basic medicine, Male, Saliva, Bostaurus, Genotype, Proteome, 030231 tropical medicine, Cattle Diseases, Immunoglobulins, Bos indicus, Tick, SALIVA, Arthropod Proteins, 03 medical and health sciences, 0302 clinical medicine, Blood serum, Tick saliva, parasitic diseases, Rhipicephalus, Animals, Salivary Proteins and Peptides, Immunoproteome, biology, Research, biology.organism_classification, bacterial infections and mycoses, Bos taurus, Tick Infestations, 030104 developmental biology, Infectious Diseases, Parasitology, Rhipicephalus microplus, Immunology, Humoral immunity, Antibody response, biology.protein, Cattle, Female, Antibody
Abstract

Background Males of the cattle tick Rhipicephalus microplus produce salivary immunoglobulin-binding proteins and allotypic variations in IgG are associated with tick loads in bovines. These findings indicate that antibody responses may be essential to control tick infestations. Infestation loads with cattle ticks are heritable: some breeds carry high loads of reproductively successful ticks, in others, few ticks feed and they reproduce inefficiently. Different patterns of humoral immunity against tick salivary proteins may explain these phenotypes. Methods We describe the profiles of humoral responses against tick salivary proteins elicited during repeated artificial infestations of bovines of a tick-resistant (Nelore) and a tick-susceptible (Holstein) breed. We measured serum levels of total IgG1, IgG2 and IgE immunoglobulins and of IgG1 and IgG2 antibodies specific for tick salivary proteins. With liquid chromatography followed by mass spectrometry we identified tick salivary proteins that were differentially recognized by serum antibodies from tick-resistant and tick-susceptible bovines in immunoblots of tick salivary proteins separated by two-dimensional electrophoresis. Results Baseline levels of total IgG1 and IgG2 were significantly higher in tick-susceptible Holsteins compared with resistant Nelores. Significant increases in levels of total IgG1, but not of IgG2 accompanied successive infestations in both breeds. Resistant Nelores presented with significantly higher levels of salivary-specific antibodies before and at the first challenge with tick larvae; however, by the third challenge, tick-susceptible Holsteins presented with significantly higher levels of IgG1 and IgG2 tick salivary protein-specific antibodies. Importantly, sera from tick-resistant Nelores reacted with 39 tick salivary proteins in immunoblots of salivary proteins separated in two dimensions by electrophoresis versus only 21 spots reacting with sera from tick-susceptible Holsteins. Conclusions Levels of tick saliva-specific antibodies were not directly correlated with infestation phenotypes. However, in spite of receiving apparently lower amounts of tick saliva, tick-resistant bovines recognized more tick salivary proteins. These reactive salivary proteins are putatively involved in several functions of parasitism and blood-feeding. Our results indicate that neutralization by host antibodies of tick salivary proteins involved in parasitism is essential to control tick infestations. Electronic supplementary material The online version of this article (doi:10.1186/s13071-017-2077-9) contains supplementary material, which is available to authorized users.

Published
2016

18. Immune recognition of salivary proteins from the cattle tick Rhipicephalus microplus differs according to the genotype of the bovine host

Author

Garcia, Gustavo Rocha, primary, Maruyama, Sandra Regina, additional, Nelson, Kristina T., additional, Ribeiro, José Marcos Chaves, additional, Gardinassi, Luiz Gustavo, additional, Maia, Antonio Augusto Mendes, additional, Ferreira, Beatriz Rossetti, additional, Kooyman, Frans N. J., additional, and de Miranda Santos, Isabel K. F., additional

Published
2017
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19. Immune and biochemical responses in skin differ between bovine hosts genetically susceptible and resistant to the cattle tick Rhipicephalus microplus

Author

Franzin, Alessandra Mara, primary, Maruyama, Sandra Regina, additional, Garcia, Gustavo Rocha, additional, Oliveira, Rosane Pereira, additional, Ribeiro, José Marcos Chaves, additional, Bishop, Richard, additional, Maia, Antônio Augusto Mendes, additional, Moré, Daniela Dantas, additional, Ferreira, Beatriz Rossetti, additional, and Santos, Isabel Kinney Ferreira de Miranda, additional

Published
2017
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20. The sialotranscriptome of Amblyomma triste, Amblyomma parvum and Amblyomma cajennense ticks, uncovered by 454-based RNA-seq

Author

Garcia, Gustavo Rocha, primary, Gardinassi, Luiz Gustavo, additional, Ribeiro, José Marcos, additional, Anatriello, Elen, additional, Ferreira, Beatriz Rossetti, additional, Moreira, Higo Nasser Santanna, additional, Mafra, Cláudio, additional, Martins, Maria Marlene, additional, Szabó, Matias Pablo Juan, additional, de Miranda-Santos, Isabel Kinney Ferreira, additional, and Maruyama, Sandra Regina, additional

Published
2014
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21. Characterisation of divergent flavivirus NS3 and NS5 protein sequences detected in Rhipicephalus microplus ticks from Brazil

Author

Maruyama, Sandra Regina, primary, Castro-Jorge, Luiza Antunes, additional, Ribeiro, José Marcos Chaves, additional, Gardinassi, Luiz Gustavo, additional, Garcia, Gustavo Rocha, additional, Brandão, Lucinda Giampietro, additional, Rodrigues, Aline Rezende, additional, Okada, Marcos Ituo, additional, Abrão, Emiliana Pereira, additional, Ferreira, Beatriz Rossetti, additional, Fonseca, Benedito Antonio Lopes da, additional, and Miranda-Santos, Isabel Kinney Ferreira de, additional

Published
2014
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23. Rhipicephalus (Boophilus) microplus: Clotting time in tick-infested skin varies according to local inflammation and gene expression patterns in tick salivary glands

Author

Carvalho, Wanessa Araújo, primary, Maruyama, Sandra Regina, additional, Franzin, Alessandra Mara, additional, Abatepaulo, Antônio Roberto Rodrigues, additional, Anderson, Jennifer M., additional, Ferreira, Beatriz Rossetti, additional, Ribeiro, José Marcos Chaves, additional, Moré, Daniela Dantas, additional, Augusto Mendes Maia, Antonio, additional, Valenzuela, Jesus G., additional, Garcia, Gustavo Rocha, additional, and de Miranda Santos, Isabel K. Ferreira, additional

Published
2010
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24. Vaccines for the Leishmaniases: Proposals for a Research Agenda.

Author

Costa, Carlos Henrique Nery, Peters, Nathan C., Maruyama, Sandra Regina, de Brito Jr., Eldo Cardoso, and de Miranda Santos, Isabel Kinney Ferreira

Subjects
LEISHMANIASIS, PARASITIC diseases, VACCINE development, VACCINES
Abstract

The article discusses the challenges in developing vaccines for the leishmaniases, a group of parasitic diseases that cause significant harm worldwide. It emphasizes the importance of understanding the mechanisms of protective immunity and the role of vector saliva and parasite proteo-phosphoglycans in vaccine development. The article also highlights the need for more research on antigens and the potential of new sequencing technologies to identify targets for vaccines. It concludes by emphasizing the need for funding, collaboration, and a unified approach to address the neglected issue of leishmaniases. [Extracted from the article]

Published
2011
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25. Dataset of dual RNA-seq mapping in visceral leishmaniasis: Inquiry on parasite transcripts in human blood transcriptome upon Leishmania infantum infection.

Author

Gomes E, Rogerio LA, Takamiya NT, Torres C, da Silva JS, Almeida RP, and Maruyama SR

Abstract

This dataset is related to the article "Insight Into the Long Noncoding RNA and mRNA Coexpression Profile in the Human Blood Transcriptome Upon Leishmania infantum Infection" by S.R. Maruyama, C.A. Fuzo, A.E.R. Oliveira, L.A. Rogerio, N.T. Takamiya, G. Pessenda, E.V. de Melo, A.M. da Silva, A.R. Jesus, V. Carregaro, H.I. Nakaya, R.P. Almeida and J.S. da Silva. Frontiers in Immunology, 2022. Through the reuse of raw sequencing data, we generated original dataset by performing a dual RNA-seq mapping procedure to survey the parasite transcripts found in RNA-seq samples from blood of visceral leishmaniasis patients. Diseased patients with active infection displayed the highest number of reads mapped to L. infantum genome. Even after six months later of the treatment, when the patients were considered cured, parasite reads were still detected. Parasite reads were also detected in asymptomatic individuals. The original dual RNA-seq alignment read count data provided here can be further explored to evaluate either host or parasite transcripts., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2022 The Author(s).)

Published
2022
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