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In this paper, a comprehensive review is performed on hybrid systems using electrical Heat Pumps for Heating, Ventilation & Air Conditioning systems and Domestic Hot Water production using case studies from 2016 to 2022. This work particularly focuses on studies that investigated systems with electrical Heat Pumps assisted by a gas boiler. Some studies that considered the exploitation of renewable energy sources, but not as a whole sub-stitute for fossil sources, have also been included. In particular, the analysis investigated the layouts of the systems by considering the type and the size of the components, the control methods applied (by distinguishing rule-based control methods and predictive control methods), and the main performance indices used to calculate energy, exergy, environmental and economic performance. Most of the analysed studies demonstrated that the hybrid systems could be very advantageous if the switch or the integration of the two generators is well managed. Nevertheless, the energy and economic performances are very different for each system studied. They are highly influenced by the control strategies implemented and by the objective functions adopted. Furthermore, climate can influence performance while affecting the Coefficient Of Performance of the heat pump and the availability of energy sources. Regarding economic issues, the systems' performances vary according to specific Country tariff structures. The review reported a promising research activity also pursued by manufacturers of components and equipment. Nevertheless, the paper highlights new possible research and development directions.

Neuroinflammation, a hallmark of chronic neurodegenerative disorders, is characterized by sustained glial activation and the generation of an inflammatory loop, through the release of cytokines and other neurotoxic mediators that cause oxidative stress and limit functional repair of brain parenchyma. Dietary antioxidants may protect against neurodegenerative diseases by counteracting chronic neuroinflammation and reducing oxidative stress. Here, we describe the effects of a number of natural antioxidants (polyphenols, carotenoids, and thiolic molecules) in rescuing astrocytic function and neuronal viability following glial activation by reducing astrocyte proliferation and restoring astrocytic and neuronal survival and basal levels of reactive oxygen species (ROS). All antioxidant molecules are also effective under conditions of oxidative stress and glutamate toxicity, two maladaptive components of neuroinflammatory processes. Moreover, it is remarkable that their antioxidant and anti-inflammatory activity occurs through differential modulation of NF-κB binding activity in neurons and astrocytes. In fact, we show that inflammatory stimuli promote a significant induction of NF-κB binding activity in astrocytes and its concomitant reduction in neurons. These changes are prevented in astrocytes and neurons pretreated with the antioxidant molecules, suggesting that NF-κB plays a key role in the modulation of survival and anti-inflammatory responses. Finally, we newly demonstrate that effective antigliosis and neuroprotective activity is achieved with a defined cocktail of four natural antioxidants at very low concentrations, suggesting a promising strategy to reduce inflammatory and oxidative damage in neurodegenerative diseases with limited side effects.

How the network around ROS protects against oxidative stress and Parkinson’s disease (PD), and how processes at the minutes timescale cause disease and aging after decades, remains enigmatic. Challenging whether the ROS network is as complex as it seems, we built a fairly comprehensive version thereof which we disentangled into a hierarchy of only five simpler subnetworks each delivering one type of robustness. The comprehensive dynamic model described in vitro data sets from two independent laboratories. Notwithstanding its five-fold robustness, it exhibited a relatively sudden breakdown, after some 80 years of virtually steady performance: it predicted aging. PD-related conditions such as lack of DJ-1 protein or increased α-synuclein accelerated the collapse, while antioxidants or caffeine retarded it. Introducing a new concept (aging-time-control coefficient), we found that as many as 25 out of 57 molecular processes controlled aging. We identified new targets for “life-extending interventions”: mitochondrial synthesis, KEAP1 degradation, and p62 metabolism.

Neuroinflammation, a hallmark of chronic neurodegenerative disorders, is characterized by sustained glial activation and the generation of an inflammatory loop, through the release of cytokines and other neurotoxic mediators that cause oxidative stress and limit functional repair of brain parenchyma. Dietary antioxidants may protect against neurodegenerative diseases by counteracting chronic neuroinflammation and reducing oxidative stress. Here, we describe the effects of a number of natural antioxidants (polyphenols, carotenoids, and thiolic molecules) in rescuing astrocytic function and neuronal viability following glial activation by reducing astrocyte proliferation and restoring astrocytic and neuronal survival and basal levels of reactive oxygen species (ROS). All antioxidant molecules are also effective under conditions of oxidative stress and glutamate toxicity, two maladaptive components of neuroinflammatory processes. Moreover, it is remarkable that their antioxidant and anti-inflammatory activity occurs through differential modulation of NF-κB binding activity in neurons and astrocytes. In fact, we show that inflammatory stimuli promote a significant induction of NF-κB binding activity in astrocytes and its concomitant reduction in neurons. These changes are prevented in astrocytes and neurons pretreated with the antioxidant molecules, suggesting that NF-κB plays a key role in the modulation of survival and anti-inflammatory responses. Finally, we newly demonstrate that effective antigliosis and neuroprotective activity is achieved with a defined cocktail of four natural antioxidants at very low concentrations, suggesting a promising strategy to reduce inflammatory and oxidative damage in neurodegenerative diseases with limited side effects.

The achievement of United Nations Sustainable Development Goals, related to energy and resource use, is a critical issue for small and insulated communities. In many minor islands, solar energy is not correctly exploited, and electrical heaters are connected to weak grids with very a high share of generation by fossil fuels. As a consequence, there is the necessity to assess the potential and the suitability of diffusion of alternative systems to avoid dependency on the electrical grid and reduce carbon emissions. This paper aims to evaluate the technical and economic performances of some alternative systems exploiting renewable energy for domestic hot water production. Four different systems were simulated and studied: a heat pump connected to the grid, a heat pump coupled with a photovoltaic plant, a heat pump combined with a solar thermal collector, and a solar thermal plant. Moreover, heat and electricity storages were studied for reducing impacts on the distribution network. The work presents data gathered for a study on energy-retrofit strategies on Lampedusa Island (Italy, 35&deg, 30&prime, 56&Prime, north (N), 568 degree-days). Finally, to select the most cost-effective plant, an economic analysis of the chosen systems was carried out. This analysis shows that the best net present values are associated with the heat pump (HP) coupled with a stand-alone PV system and a small battery and solar thermal-assisted HP. The shortest payback time was calculated for the solar thermal system.

Background/Aim: Abemaciclib is a cyclin-dependent kinase 4/6 inhibitor approved in combination with endocrine therapy for treating hormone receptor-positive and human epidermal growth factor receptor 2-negative early and advanced breast cancer patients. The safety profile of abemaciclib is characterized by frequent gastrointestinal toxicity, especially diarrhea. Therefore, we performed an exploratory analysis of clinical factors that may be potentially associated with diarrhea in patients treated with abemaciclib plus endocrine therapy. Patients and Methods: Factors potentially predisposing to diarrhea were selected, such as age ≥70 years, concomitant medications and diseases, diet, and use of laxatives. These variables were correlated with the onset of grade 2/3 diarrhea in a cohort of patients treated with abemaciclib from advanced breast cancer. Univariate and multivariate analysis was performed. Sensitivity and specificity were tested using the ROC curve. Results: Eighty women with advanced breast cancer were included in the study. The univariate analysis found a statistically significant correlation between grade 2/3 diarrhea and age ≥70 years, polypharmacy, and concomitant gastrointestinal diseases (p