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10. Editorial: Global excellence in neural circuits: Central and South America.

Author

Martins-Silva, Cristina

Subjects
OTOACOUSTIC emissions, NERVOUS system, FREQUENCIES of oscillating systems, CEREBRAL cortex, NEURAL circuitry
Abstract

This document is an editorial published in the journal Frontiers in Neural Circuits. The editorial discusses the importance of studying neural circuits in order to understand different behaviors and how the environment influences them. It highlights two studies conducted in South America, one on alterations in corticofugal pathways in patients with tinnitus, and another on the role of the prefrontal cortex in cognitive control of behavior. The editorial emphasizes the value of research on neural circuits conducted in South America as a source of information for neuroscientists worldwide. [Extracted from the article]

Published
2024
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14. The Environmental Pollutant Tributyltin Chloride Disrupts the Hypothalamic-Pituitary-Adrenal Axis at Different Levels in Female Rats

Author

Merlo, Eduardo, primary, Podratz, Priscila L., primary, Sena, Gabriela C., primary, de Araújo, Julia F. P., primary, Lima, Leandro C. F., primary, Alves, Izabela S. S., primary, Gama-de-Souza, Letícia N., primary, Pelição, Renan, primary, Rodrigues, Lívia C. M., primary, Brandão, Poliane A. A., primary, Carneiro, Maria T. W. D., primary, Pires, Rita G. W., primary, Martins-Silva, Cristina, primary, Alarcon, Tamara A., primary, Miranda-Alves, Leandro, primary, Silva, Ian V., primary, and Graceli, Jones B., primary

Published
2016
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16. Role of brainstem serotonin in analgesia produced by low-intensity exercise on neuropathic pain after sciatic nerve injury in mice

Author

Bobinski, Franciane, primary, Ferreira, Tamara A.A., additional, Córdova, Marina M., additional, Dombrowski, Patrícia A., additional, da Cunha, Cláudio, additional, Santo, Caroline C. do Espírito, additional, Poli, Anicleto, additional, Pires, Rita G.W., additional, Martins-Silva, Cristina, additional, Sluka, Kathleen A., additional, and Santos, Adair R.S., additional

Published
2015
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17. Behavioral, Biochemical and Molecular Characterization of a Parkinson’s Disease Mouse Model Using the Neurotoxin 2′-CH3-MPTP: A Novel Approach.

Author

Herlinger, Alice Laschuk, Almeida, Agihane Rodrigues, Presti-Silva, Sarah Martins, Pereira, Evaldo Vitor, Andrich, Filipe, Pires, Rita Gomes Wanderley, and Martins-Silva, Cristina

Abstract

The neurotoxin MPTP has long been used to create a mouse model of Parkinson’s disease (PD). Indeed, several MPTP analogues have been developed, including 2′-CH3-MPTP, which was shown to induce nigrostriatal DA neuronal depletion more potently than MPTP. However, no study on behavioral and molecular alterations in response to 2′-CH3-MPTP has been carried out so far. In the present work, 2′-CH3-MPTP was administered to mice (2.5, 5.0 and 10 mg/kg per injection, once a day, 5 days) and histological, biochemical, molecular and behavioral alterations were evaluated. We show that, despite a dose-dependent-like pattern observed for nigrostriatal dopaminergic neuronal death and dopamine depletion, dose-specific alterations in dopamine metabolism and in the expression of dopaminergic neurotransmission-associated genes could be related to specific motor deficits elicited by the different doses tested. Interestingly, 2′-CH3-MPTP leads to increased DAT and MAO-B transcription, which could explain, respectively, its higher potency and the requirement of higher doses of MAO inhibitors to prevent nigrostriatal neuronal death when compared to MPTP. Also, perturbations in dopamine metabolism as well as possible alterations in dopamine bioavailability in the synaptic cleft were also identified and correlated with strength and ambulation deficits in response to specific doses. Overall, the present work brings new evidence supporting the distinct effects of 2′-CH3-MPTP when compared to its analogue MPTP. Moreover, our data highlight the utmost importance of a precise experimental design, as different administration regimens and doses yield different biochemical, molecular and behavioral alterations, which can be explored to study specific aspects of PD. [ABSTRACT FROM AUTHOR]

Published
2018
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18. Novel Strains of Mice Deficient for the Vesicular Acetylcholine Transporter: Insights on Transcriptional Regulation and Control of Locomotor Behavior

Author

Martins-Silva, Cristina, primary, De Jaeger, Xavier, additional, Guzman, Monica S., additional, Lima, Ricardo D. F., additional, Santos, Magda S., additional, Kushmerick, Christopher, additional, Gomez, Marcus V., additional, Caron, Marc G., additional, Prado, Marco A. M., additional, and Prado, Vania F., additional

Published
2011
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19. Downregulation of the cAMP/PKA Pathway in PC12 Cells Overexpressing NCS-1

Author

Souza, Bruno R., primary, Torres, Karen C. L., additional, Miranda, Débora M., additional, Motta, Bernardo S., additional, Caetano, Fernando S., additional, Rosa, Daniela V. F., additional, Souza, Renan P., additional, Giovani, Antônio, additional, Carneiro, Daniel S., additional, Guimarães, Melissa M., additional, Martins-Silva, Cristina, additional, Reis, Helton J., additional, Gomez, Marcus. V., additional, Jeromin, Andreas, additional, and Romano-Silva, Marco A., additional

Published
2010
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20. The Vesicular Acetylcholine Transporter Is Required for Neuromuscular Development and Function

Author

de Castro, Braulio M., primary, De Jaeger, Xavier, additional, Martins-Silva, Cristina, additional, Lima, Ricardo D. F., additional, Amaral, Ernani, additional, Menezes, Cristiane, additional, Lima, Patricia, additional, Neves, Cintia M. L., additional, Pires, Rita G., additional, Gould, Thomas W., additional, Welch, Ian, additional, Kushmerick, Christopher, additional, Guatimosim, Cristina, additional, Izquierdo, Ivan, additional, Cammarota, Martin, additional, Rylett, R. Jane, additional, Gomez, Marcus V., additional, Caron, Marc G., additional, Oppenheim, Ronald W., additional, Prado, Marco A. M., additional, and Prado, Vania F., additional

Published
2009
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21. A rat homologue of CED-6 is expressed in neurons and interacts with clathrin

Author

Martins-Silva, Cristina, primary, Ferreira, Lucimar Teodoro, additional, Cyr, Michel, additional, Koenen, Janaina, additional, Ramires Fernandes, Diane, additional, Rodrigues Carvalho, Natalia, additional, Ribeiro, Caroline Batista Franco, additional, Marion, Sébastien, additional, Chavez-Olortegui, Carlos, additional, Prado, Marco Antonio Maximo, additional, and Prado, Vania Ferreira, additional

Published
2006
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22. Mice Deficient for the Vesicular Acetylcholine Transporter Are Myasthenic and Have Deficits in Object and Social Recognition

Author

Prado, Vania F., primary, Martins-Silva, Cristina, additional, de Castro, Braulio M., additional, Lima, Ricardo F., additional, Barros, Daniela M., additional, Amaral, Ernani, additional, Ramsey, Amy J., additional, Sotnikova, Tatyana D., additional, Ramirez, Maria R., additional, Kim, Hyung-Gun, additional, Rossato, Janine I., additional, Koenen, Janaina, additional, Quan, Hui, additional, Cota, Vinicius R., additional, Moraes, Marcio F.D., additional, Gomez, Marcus V., additional, Guatimosim, Cristina, additional, Wetsel, William C., additional, Kushmerick, Christopher, additional, Pereira, Grace S., additional, Gainetdinov, Raul R., additional, Izquierdo, Ivan, additional, Caron, Marc G., additional, and Prado, Marco A.M., additional

Published
2006
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