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Funding Information: This research was funded by FWO and F.R.S.-FNRS under the Excellence of Science Program (EOS), MODEL-IDI Ref. number 30826052, and CD-INFLADIS Ref. number 40007512. A.C.P. is funded by FCT SFRH/BD/14611/2019. I.S.L was funded by FCT SFRH/BD/114552/2016 and is funded by MODEL-IDI Ref. number 30826052; A.C.M. was funded by FCT SFRH/BD/104599/2014; R.G. was funded by FCT IF 01495/2015. Publisher Copyright: © 2023 by the authors. Sub-chronic inflammation, caused by age-related dysbiosis, primes the brain to neuroinflammation and neurodegenerative diseases. Evidence revealed that Parkinson’s disease (PD) might originate in the gut, demonstrating gastro-intestinal disturbances, as reported by PD patients long before developing motor symptoms. In this study, we conducted comparative analyses in relatively young and old mice maintained in conventional or gnotobiotic conditions. We aimed to confirm that the effects induced by age-related dysbiosis, rather than aging itself, sensitize to PD onset. This hypothesis was confirmed in germ-free (GF) mice, which proved resistant to the pharmacological induction of PD, regardless of their age. Contrary to conventional animals, old GF mice did not develop an inflammatory phenotype or an accumulation of iron in the brain, two catalysts sensitizing to disease onset. The resistance of GF mice to PD is reverted when colonized with stool collected from conventional old animals, but not if receiving bacterial content from young mice. Hence, changes in gut microbiota composition are a risk factor for PD development and can be targeted preventively by iron chelators, shown to protect the brain from pro-inflammatory intestinal priming that sensitizes to neuroinflammation and the development of severe PD. publishersversion published

In the case of older buildings undergoing renovation, excessive loads are often not well tolerated by roofs or other building structures (e.g. facades) [1, 2], which limits the adoption of PV in these contexts. The idea of lightweight modules is very attractive especially for the building-integration of photovoltaics (BIPV) thanks to their reduced weight and strong improvements in durability [3–5]. On the other hand, the thick alternative light backsheet structure of such modules may be seen as a disadvantage, because it may induce higher module operating temperatures (OT). This work demonstrates that lightweight (≈ 6 kg/m2) photovoltaic module based on a composite sandwich backsheet and a polymeric frontsheet can reach equivalent (or lower) operating temperatures of standard glass-glass modules thanks to a careful material selection.

P. 555-60,jul./ago. Submitted by JURANDI DE SOUZA SILVA (jssufba@hotmail.com) on 2011-10-18T17:19:17Z No. of bitstreams: 1 a19v70n4.pdf: 183188 bytes, checksum: bd6aaf879898fb95a42f2dbbfec45a82 (MD5) Made available in DSpace on 2011-10-18T17:19:17Z (GMT). No. of bitstreams: 1 a19v70n4.pdf: 183188 bytes, checksum: bd6aaf879898fb95a42f2dbbfec45a82 (MD5) Previous issue date: 2004 O granuloma reparativo de células gigantes é um tumor ósseo não-neoplásico incomum que representa menos que 7% dos tumores mandibulares, sua localização mais freqüente. Porém, já foi descrito em seios paranasais, ossos temporais e órbita. O presente trabalho descreve um paciente com granuloma reparativo de células gigantes em seios maxilar e etmoidal, comprometendo também, em menor extensão, os seios esfenoidal e frontal, e um outro paciente com acometimento circunscrito ao seio maxilar. Clinicamente, apresentam-se com proptose acentuada e macromala unilaterais, respectivamente. Os achados clínicos, tomográficos, histopatológicos e terapêuticos são descritos, ao lado de uma revisão da literatura com ênfase no diagnóstico diferencial, sobretudo com o tumor de células gigantes. São Paulo

A Paracoccidioidomicose (PCM) é uma micose profunda sistêmica causada por um fungo dimorfo, de aspecto microscópico similar a roda de leme de navio, o Paracoccidioides brasiliensis (Pb). A PCM apresenta distribuição geográfica restrita ao continente americano, acomete sobretudo indivíduos do sexo masculino, sem predileção por raça. Seu quadro clínico é bastante variado. OBJETIVO: Realizar análise epidemiológica de 26 casos de PCM avaliados no Setor de Otorrinolaringologia da Fundação Oswaldo Cruz - FIOCRUZ. FORMA DE ESTUDO: Clínico retrospectivo. MATERIAL E MÉTODO: Estudou-se retrospectivamente 26 prontuários de pacientes com manifestações otorrinolaringológicas da PCM atendidos no período de outubro de 1998 a setembro de 2001. Avaliou-se: sexo, idade, profissão, grau de escolaridade, se etilistas e/ou tabagistas, sintomatologia, local das lesões, presença de co-infecção, exames complementares realizados e opção terapêutica. RESULTADOS: 23 (88,5%) pacientes eram do sexo masculino e 3 (11,5%) do sexo feminino, com idade entre 32 e 72 anos. 11 (42,3%) pacientes eram agricultores e 21 (80,8%) tabagistas e/ou etilistas. Os locais mais comumente atingidos foram a epiglote e a parede nasal lateral. Utilizaram-se derivados sulfamídicos para o tratamento de 14 (53,9%) pacientes e imidazólicos em 12 (46,1%) casos. DISCUSSÃO: Lesões pulmonares podem ser confundidas com tuberculose, devido a suas semelhanças clínicas e radiográficas. A desnutrição pode predispor quadros clínicos de extrema gravidade. CONCLUSÃO: A anamnese detalhada dos pacientes portadores de PCM revela importantes aspectos, como procedência e hábitos pessoais. A atuação interdisciplinar, sobretudo de médicos e dentistas, colabora para um precoce diagnóstico e adequado acompanhamento do doente. Paracoccidioidomycosis (PCM) is an acute systemic mycosis caused by a dimorphous fungus, Paracoccidioides brasiliensis (Pb), whose appearance under the microscope is similar to a ship rudder's wheel. Cases of PCM are restricted to the American continent and the disease affects mostly male individuals, with no marked tendency to affect any race in particular. Clinical symptoms are varied. OBJECTIVE: To carry out a thorough epidemiological analysis of 26 cases of PCM evaluated at the Oswaldo Cruz Foundation (FIOCRUZ) Otorhinolaryngology (ENT) Sector. STUDY DESIGN: Clinical retrospective. MATERIAL AND METHOD: A retrospective study was carried out on 26 medical charts of patients with otorhinolaryngological manifestations of PCM who were attended to from October 1998 to September 2001. Aspects taken into account: sex, age, occupation, number of years of schooling, smoking and drinking habits, main complaints, parts of the body presenting most lesions, the presence of co-infection, complementary examinations done, prescribed treatment. RESULTS: 23 patients (88.5%) were male and 3 (11,5%) were female, their ages ranging from 32 to 72. 11 patients (42.3%) were farm workers and 21 (80.8%) were heavy smokers and/or drinkers. The most affected parts were the epiglottis and the lateral nasal wall. Sulphonamide derivatives were used to treat 14 patients (53.9%) and imidazoles were used for 12 cases (46.1%). DISCUSSION: Pulmonary lesions may be mistaken for tuberculosis due to clinical and radiological similarities. Malnutrition may lead to clinical conditions of extreme gravity. CONCLUSION: The detailed medical histories of PCM carriers reveal important aspects such us the patients' origins and personal habits. Interdisciplinary actions, especially involving doctors and dentists, contribute to an early diagnosis and adequate treatment and follow-up of patients.