Search

Uvod: Uloga endoglina i prognostičko značenje angiogeneze u Dukes B karcinomu rektuma još uvijek su nedovoljno neistraženi. Hipoteza i ciljevi: Ekspresija endoglina i mikrovaskularna gustoća su prognostički čimbenici rizika kod bolesnika s Dukes B karcinomom rektuma. Cilj ovog istraživanja je ispitati ekspresiju endoglina (CD105) u reseciranim uzorcima karcinoma rektuma i odnos između mikrovaskularne gustoće (MVD), kliničkopatoloških čimbenika, preživljenja bolesnika i recidiva tumora. Materijali i metode: U istraživanje je uključeno 95 uzoraka primarnog adenokarcinoma rektuma, 67 uzoraka korespondentne susjedne normalne sluznice i 73 uzorka udaljene normalne sluznice uzetih od kirurškog preparata reseciranog tumora rektuma. Uzorci su uklopljeni u parafin i imunohistokemijski obojeni na CD105 endotelni antigen te je provedeno brojanje malih krvnih žila. Za točno mjerenje CD105-MVD korišten je računalno objedinjeni sustav Alphelys Spot Browser 2. Rezultati: CD105-MVD u tumoru bila je značajno veća u usporedbi s korespondentnom susjednom sluznicom (P, Background: The role endoglin in the Dukes B rectal cancer still unexplored. The aim of this study was to examine the expression of endoglin (CD105) in resected rectal cancer and evaluate the relationship between microvessels density (MVD), clinicopathological factors and survival. Hypothesis and Objectives: Endoglin expression and microvessel density are prognostic risk factors in patients with Dukes B rectal cancer. The aim of this study was to determine the endoglin expression in resected specimens of rectal cancer and the relationship between microvessel density (MVD), clinical and pathological factors, patients survival and tumor recurrence. Materials and Method: The study included 95 primary rectal adenocarcinomas, corresponding 67 adjacent and 73 distant normal mucosa specimens from surgical resection samples. Tumor specimens were paraffin-embedded and immunohistochemical staining for the CD105 endothelial antigen was performed to count CD105-MVD. For exact measurement of the CD105-MVD used a computer-integrated system Alphelys Spot Browser 2. Results: The intratumoral CD105-MVD was significantly higher compared with corresponding adjacent mucosa (P

Doktorski rad se bavi problemom umjeravanja prijenosnih mjernih etalona za mjerenje snage i efektivne vrijednosti izmjeničnoga signala korištenjem mikrokalorimetra. Mikrokalorimetar predstavlja instrument kojim se mjeri efikasnost umjeravanog etalona putem određivanja gubitaka snage uslijed toplinskih efekata. Prikazana izvedba mikrokalorimetra sastoji se od sljedećih elemenata: dvostrukog termostata; izolacijskog sloja u koaksijalnom vodu (optimizacija toplinskog protoka); koaksijalnog voda za prijenos signala; termoelemenata za mjerenje gubitaka snage u bolometarskom kućištu; istosmjernih komponenti potrebnih za održavanje bolometarskog elementa u ravnoteži. Određivanje korekcije gubitaka mikrokalorimetra provodi se mjerenjem gubitaka uslijed toplinskih efekata (gubici u konektorima i u kućištu bolometra). Cilj ovog rada je razvoj mikrokalorimetra za precizno mjerenje snage u frekvencijskom području od 500 MHz – 6 GHz namijenjenog za primjenu u pametnim mrežama. U prvom poglavlju (1. Uvod) je sažeto prikazana motivacija i ciljevi doktorskog rada, te je razrađen sadržaj rada. Također, navedeni su pojedini dijelovi rada koji su prethodili konačnoj realizaciji mikrokalorimetarskog mjerenja snage izmjeničnog signala temeljenoga na samouravnotežujućem mostu. U drugom poglavlju (2. Mikrokalorimetri i prijenosni etaloni) sažeto je prikazan razvoj mikrokalorimetara tijekom desetljeća s posebnim naglaskom na komponente od kojih se mikrokalorimetar sastoji. Također, dan je osvrt na najnovija istraživanja u području te put do pojave mikrokalorimetara s prekidom u vanjskom vodiču adijabatske linije. U trećem poglavlju (3. Komunikacija pametnih mreža i prikupljanje energije iz okoline) dan je uvod u komunikacije pametnih mreža gdje postoji primjena mikrokalorimetra u umjeravanju, s posebnim osvrtom na postojeće bežične komunikacijske mreže te frekvencijske raspone. U četvrtom poglavlju (4. Definicija električne snage) dana je definicija električne snage prema normi IEEE Std 1459TM - 2010. Navedena norma opisuje komponente snage te teoretske osnove mjerenja snage. vi U petom poglavlju (5. Precizno mjerenje snage i efektivne vrijednosti izmjeničnog signala) sažeto je prikazan mjerni postupak preciznog mjerenja snage korištenjem termalnih detektora snage s posebnim naglaskom na proceduru umjeravanja. Ukratko su opisani i termalni pretvornici te njihove mogućnosti za mjerenje snage na visokim frekvencijama. U šestom poglavlju (6. Mikrokalorimetarsko mjerenje snage na visokim frekvencijama) dan je opis procedure mjerenja snage na visokim frekvencijama korištenjem mikrokalorimetra. Ovo poglavlje predstavlja najvažnije poglavlje doktorskog rada jer su u njemu prikazani: simulacijski rezultati adijabatske linije, prototip razvijenog uređaja te električna i toplinska karakterizacija adijabatske linije. Također je opisan termalni detektor korišten za izradu prototipa kao i dvostruko metalno kućište termostata. Pored navedenog, dan je opis termostata, toplinska karakterizacija i temperaturna regulacija termostata te termopila. U sedmom poglavlju (7. Uravnoteženje mosnog spoja) opisan je postupak uravnoteženja mosnog spoja uz akviziciju mjernih podataka digitalnim multimetrima razlučivosti 8 ½ digita uz sinkronizaciju i upravljanje kroz LabVIEW sustav. Osmo poglavlje je zaključak. PhD thesis addresses the calibration of power and effective AC measurement standards for the measurement of power and RMS value of AC signals. Microcalorimeter represents an instrument for effective efficiency measurements of test standard by measuring losses due to heat transfer. Design of the microcalorimeter is based on modelling: double shielded housing; isolation section (heat transfer optimization); coaxial transmission line; elements for detection of losses in bolometer housing; DC components for the realization of bridge circuit in order to hold bolometer constant resistance; A correction factor of microcalorimeter is determined by measuring heat losses and heat effects (losses in connectors, in bolometer mount). The main purpose of PhD dissertation was to develop a microcalorimeter structure for accurate power measurement in the frequency range of 500 MHz - 6 GHz intended for use in smart grids. The first chapter (1. Introduction) summarizes the motivation and goals of the doctoral thesis and elaborates the content of the of dissertation. Also, individual parts of work that preceded the final realization of microcalorimetric measurements of AC signal power based on a selfbalancing bridge are. The second chapter (2. Microcalorimeters and transfer standards) summarizes the development of microcalorimeters over the decades with special emphasis on the components of which the microcalorimeter consists of. Also, a review of the latest research in the field and a chronological path to the appearance of microcalorimeters with an interruption in the outer conductor of the adiabatic line is given. The third chapter (3. Smart Grid communication and energy harvesting) introduces Smart Grid communication and energy harvesting systems, where exists the application of microcalorimeters, with special reference to existing wireless communication networks and frequency bands. v In the fourth chapter (4. Definition of electrical power) the definition of electrical power is given according to the standard IEEE Std-2010. This standard describes the components of power and theoretical basis of power measurement. The fifth chapter (5. Precise measurement of power and RMS value of the AC signal) summarizes the measurement procedure for precise power measurement using thermal power detectors with special emphasis on the calibration procedure. Thermal converters and their possibilities for measuring power at high frequencies are also briefly described. Chapter 6 (6. Microcalorimetric Power Measurement at High Frequencies) describes the procedure for measuring the power at high frequencies using a microcalorimeter. This chapter is the most important chapter of the doctoral thesis because it presents: simulation results of the adiabatic line, a prototype of the developed device and electrical and thermal characterization of the adiabatic line. Also, thermal detector is described which is used in prototype as well as a double metal thermostat housing. In addition to the above, a description of the thermal characterization and temperature regulation of the thermostat. In the seventh Chapter (7. Balancing of the bridge circuit) describes the process of balancing the bridge connection and the acquisition of measurement data by digital multimeters with a resolution of 8 ½ digital with synchronization and control through the LabVIEW system. The eight chapter are conclusions.

The paper presents the results of the FEM analysis of a printed-circuit-board (PCB) based wireless power transfer (WPT) receiver/transmitter. The full-wave simulations were run in HFSS. The design of the transmitter and the receiver was based on the standard double-sided PCB FR4 fiberglass-epoxy material. The WPT system was analyzed for different transmitter and receiver distances (1mm – 100 mm), with and without integrated capacitance. The influence of the additional capacitance on resonant frequencies was analysed. Simulation results were compared by extracting Z parameters (impedance parameters) for different model scenarios.

Precise power measurement is usually done at national metrology institutes. In recent years researchers have devoted substantial time toward a measurement of power under nonsinusoidal conditions, especially in power grids because of renewable energy increase. The challenge is not only to measure power at 50 Hz, but also to measure harmonics and inter harmonics. To measure power at needed accuracy, accurate and frequency independent current and voltage transducers are needed up to 100 kHz. In this paper an overview and state of the art is given for current transducers used for this purpose. This mainly includes AC shunts of coaxial design, calculable resistors, precise transformers and methods for their characterization.

Wireless power transfer represents the concept of energy transfer through resonant magnetic coupling based on Maxwell electromagnetic equations. The objective of this paper is to give an overview of the wireless power transfer. The introduction will give the description of the technology, describe the system components and working model. The focus will be kept on electromagnetic phenomena inside the resonant circuit. Furthermore, the paper will present a comparison between standard (conducted) and wireless resonant Witricity technologies.

U radu je prikazana komunikacija s Arduinom odnosno komunikacija androdia uređaja s Arduinom. Cilj rada je bio ostvarit upravljanje perifernim sklopom putem Bluetooth tehnologije. Za potrebe rada korišteni su Bluetoothh USB uređaja, Bluetooth serijski adapter, ispravljač napona, Arudino severino s3v3 razvojan pločica te android samsung galaxy s1.

We investigated the relationship of efficiency in the application of the ESIN method of intramedullary osteosynthesis and other active surgical methods in the treatment of diaphyseal fractures of long bones in children and adolescents. The study comprised 100 subjects treated by elastic stable intramedullary osteosynthesis (ESIN - group A) and 50 subjects in whom other active surgical methods were applied (group B). The following criteria of efficiency of treatment were applied: 1. length of perioperative hospitalization, 2. time elapsed since the operation until the beginning of loading of the traumatized extremity, 3. time elapsed since the operation until the full loading of the extremity, i.e. until the recovery of the fracture, 4. incidence of complications, 5. number of post-operative outpatient clinical visits until the recovery of the fracture and 6. overall number of X-ray images of the fractured bone since the accident until the coalescence of the fracture. The results obtained in both groups were compared. 1. The length of perioperative hospitalization is shorter in patients in whom ESIN method was applied. The difference between arithmetic means was 4.45 days and is statistically significant (p < 0.001). 2. The time between the operation until the beginning of loading of the extremity is shorter in patients subjected to ESIN method of osteosynthesis, the difference of mean values being 23.49 days and is statistically significant (p < 0.001). 3. The time between the operation until the full loading of the extremity is shorter in patients subjected to ESIN method of osteosynthesis, the difference being 16.6 days and is statistically significant (p < 0.001). 4. The number of complications in patients treated by the ESIN method of osteosynthesis is not statistically different from that in group B (chi2 = 0.25, p = 0.62). 5. In postoperative period there were fewer outpatient controls in patients to whom ESIN method of osteosynthesis was applied, and the difference is statistically significant (Z = 7.69, p < 0.001). 6. Likewise, the overall number of X-ray controls was lesser (Z = 8.06, p < 0.001). The results of examining the above parameters point to a greater efficiency of treating diaphyseal fractures of long bones in children and adolescents by the ESIN method of osteosynthesis, compared to other active surgical methods.

Through the treatment of anaemia in dialysis patients part of the iron ions remain free in the serum which is at the bacterias disposal for growth and the strengthening of their virulence. The linear relation of the increased serum iron level and tissue iron stores in the body and the infection incidence in dialysed patients has become more emphasised. The need of a clearly defined upper threshold of the serum iron concentration limit has been mentioned in scientific journals intensely, and consequently the demand for more precise professional instructions for anaemia treatment. For the purpose of participating in these professional and scientific discussions, we have observed the relation between the iron overload of the organism and complication incidence in 120 of our haemodialysis uremic patients, with special emphasis on infections. It has been established that the sepses incidence is much higher in patients with a serum ferritin concentration above 500 microg/L, than in those patients with a ferritin level lower than the mentioned value (Chi2 = 7.857, p = 0.005). The incidence of vascular access infection is significantly higher in those patients with a serum ferritin level above 500 microg/L than in those patients with a ferritin level lower than the mentioned value (Chi2 = 23.186, p = 0.001). Furthermore, it has been determined that the incidence of total infection in patients is 3.8 episodes per 100 patients months, which is in accordance to the referral values of other authors. CONCLUSION--In the analysis of the achieved results, it has been determined that the infection incidence is significantly higher in dialysed patients with a serum iron level higher than 500 microg/L, than in those patients with lower values.

Introduction. Sleep bruxism as nocturnal parafunction, also known as tooth grinding, is the most common parasomnia (sleep disorder). Most tooth grinding occurs during rapid eye movement - REM sleep. Sleep bruxism is an oral habit characterized by rhythmic activity of the masticatory muscles (m. masseter) that causes forced contact between dental surfaces during sleep. Sleep bruxism has been associated with craniomandibular disorders including temporomandibular joint discomfort, pulpalgia, premature loss of teeth due to excessive attrition and mobility, headache, muscle ache, sleep interruption of an individual and problems with removable and fixed denture. Basically, two groups of etiological factors can be distinguished, viz., peripheral (occlusal) factors and central (pathophysiological and psychological) factors. The role of occlusion (occlusal discrepancies) as the causative factor is not enough mentioned in relation to bruxism. Objective. The main objective of this paper was to evaluate the connection between occlusal factors and nocturnal parafunctional activities (occlusal disharmonies and bruxism). Method. Two groups were formed- experimental of 15 persons with signs and symptoms of nocturnal parafunctional activity of mandible (mean age 26.6 years) and control of 42 persons with no signs and symptoms of bruxism (mean age 26.3 yrs.). The computerized occlusal analyses were performed using the T-Scan II system (Tekscan, Boston, USA). 2D occlusograms were analyzed showing the occlusal force, the center of the occlusal force with the trajectory and the number of antagonistic tooth contacts. Results. Statistically significant difference of force distribution was found between the left and the right side of the arch (L%-R%) (t=2.773; p lt 0.02) in the group with bruxism. The difference of the centre of occlusal force - COF trajectory between the experimental and control group was not significant, but the trajectory of COF was longer in the group of bruxists (67.3±24.4mm). In addition, the significant difference of COF position in relation to the center of the elliptic fields was not found in bruxists (χ2=1.63; p> 0.05), but obtained results directly revealed uneven distribution of the occlusal forces which caused the excessive attrition and mobility of tooth. Conclusion. Our study failed to find direct correlation between occlusal factors and bruxism, so they are basically contributing factors., Uvod. Bruksizam je noćna parafunkcionalna aktivnost mandibule i svrstava se u parasomniju ili poremećaj spavanja. Javlja se u REM fazi sna u vidu ritmične hiperaktivnosti mastikatornih mišića (m. masseter) koja destruktivno deluje skoro na sve komponente orofacijalnog sistema. Posledice ovog fenomena su trošenje zubnog tkiva, bol usled spazma mišića, miogene i artrogene disfunkcije sa mogućim degenerativnim intrakapsulnim promenama, pulpalgija, oboljenja parodoncijuma, glavobolje, naročito u jutarnjim časovima, i problemi različite prirode na pokretnim i fiksnim zubnim nadoknadama (trošenje akrilatnih zuba i akrilatnih faseta). U etiologiji bruksizma najčešće učestvuju periferni okluzalni i centralni psihogeni faktori. Uloga okluzije u etiologiji bruksizma nije dovoljno istražena niti definisana. Cilj rada. Cilj istraživanja je bio da se utvrdi veza između okluzalnih disharmonija i bruksizma, odnosno da se proceni značaj okluzije u nastanku bruksizma. Metod rada U istraživanje su uključene eksperimentalna i kontrolna grupa ispitanika. Eksperimentalnu grupu činilo je 15 ispitanika s evidentnim znacima i simptomima bruksizma, prosečne starosti od 26,6 godina, a kontrolnu grupu 42 osobe s izostankom bruksizma, prosečne starosti od 26,3 godine. Okluzija je analizirana kompjuterski, T-Scan II sistemom. Na dvodimenzionalnim kompjuterskim okluzogramima komentarisani su sledeći parametri: okluzalna opterećenja, centar okluzalnih sila i njegova putanja i broj antagonističkih parova zuba. Rezultati Kompjuterska analiza okluzije ukazuje na značajne razlike u opterećenju leve i desne strane (L%-D%) zubika (t=2,773; p lt 0,02) u korist ispitanika sa bruksizmom. Razlika u trajektorijumu centra okluzalnih sila (COF) nije značajna, ali je kod osoba sa bruksizmom trajektorijum COF duži (67,3±24,4 mm). Kod ispitanika sa bruksizmom takođe nije utvrđena statistički značajna razlika u položaju COF u odnosu na centar eliptičnih polja (χ2= 1,63; p>0,05), međutim, dobijeni rezultati ukazuju na evidentno neuravnoteženo opterećenje okluzije kod njih. Zaključak. Na osnovu rezultata kompjuterske analize okluzije može se zaključiti da okluzalni faktor doprinosi nastanku bruksizma.

This paper argues on importance of gingival and dental parameters in evaluation of esthetic characteristics of fixed restorations. Human beauty is a specific category which is not easy to define by means of any known criteria or with mathematic formula. But, it is also important for practitioners to take into consideration some objective rules determining what is really nice and appealing. In reconstructing the personal identity, it is essential to harmonize the esthetic features. In dental practice, this approach means to establish a close correlation among the facial, dental, gingival and physical components of orofacia! system. For the purpose of this study, the authors have divided the overview of esthetic principles into two parts. The first one deals with some objective parameters such as: gingival health, the zenith of gingival contour, the balance of gingival levels, relative tooth dimensions, the golden proportion of the teeth, the design of dental arch, interdental contact areas, interdental closure, the contour of incisal edge and the shape of interincisal angles. The esthetic integration of these parameters into a frame of smile and the whole face, as well as some subjective criteria are discussed in the second part of the paper., Dentalni i gingivni parametri imaju veliki značaj u proceni estetskih obeležja fiksnih nadoknada. Činjenica da je ljudska lepota kategorija koja se ne može apsolutno definisati ni brižljivo odabranim kriterijuma, ni matematičkim formulama ipak ne zatvara vrata razmišljanju da postoji nešto što se zove objektivno važenje, saglasnost o tome šta jeste, a šta nije lepo. U želji da se sačuva ili rekonstruiše identitet jedinke, usklađivanje estetskih obeležja je od ogromne važnosti. U stomatološkom radu ovo podrazumeva uspostavljanje bliske komunikacije između facijalnih, dentalnih, gingivnih i fizičkih komponenti orofacijalnog sistema. s obzirom na složenost aktuelne problematike, autori su podelili naznačenu temu na dva dela. Ovi komplementarni delovi se bave sveobuhvatnim razmatranjima velikog broja objektivnih i subjektivnih faktora koji determinišu validnost dentalne kompozicije rekonstruisane fiksnim nadoknadama.

Resin cements (composite luting cements) are used for cementation all ceramic crowns in contemporary dental practice. These materials which are characterized by type of fillers, initiation system, their viscosity, mechanical properties (wear resistance, elastic modulus, compressive strength, tensile and shear strength), and by their physical properties (CTE, radiopacity, polimerization shrinkage) became very popular in everyday practice. In that regard, this paper deals with some special characteristics of composite luting cements, as well as with the practical instructions during the cementation procedures connected to one of the commercial product of resin cements., Savremena stomatološka praksa koristi za cementiranje keramičkih nadoknada kompozitne cementne materijale. Definisani različitim parametrima kao što su: odgovarajuća vrsta punioca, inicijatorni sistem, viskoznost, mehaničke karakteristike (modul elastičnosti, otpornost na habanje, čvrstoća na pritisak, istezanje i smicanje) i fizička svojstva (CTE, rendgenkontrasnost, polimerizaciona kontrakcija), strogo specifični za određene namene, ovi materijali zavređuju posebnu pažnju praktičara. Stoga, ovaj rad razmatra neke od njihovih specifičnosti sa osvrtom na pravila cementiranja i korektnu tehniku pri upotrebi jednog od poznatih preparata dvostrukopolimerizujućih kompozitnih cemenata.

The objective of this paper was to show the historical perspective of the „long centric" occlusal concept and its importance in the modern dentistry, especially from the gnathological aspect. The „long centric" concept represents therapeutic modality used in modern dentistry and occlusal adjustment in all patients showing differences in strong and weak closure of the lower jaw starting from the position of physiological rest/long centric" concept is applied only for anterior teeth and occlusal movements from rather than toward the center. Whenever the „long centric" parameters are not adequate, occlusal disturbance, resulting from the „wedge" effect during the initial closure of the lower jaw, is present. Different degrees of abrasion or hypermobility of the teeth are often the result of the above-mentioned occlusal disturbances and can potentially trigger bruxism and malfunction. Modus procedendi should be the regular approach of every dentist to any occlusion, because only the built-in „long centric" efficiently contributes to the occlusal stability of the anterior portion of the dentition. All occlusions should be routinely tested regarding their need for „long centric", especially when the extensive therapeutic interventions (conservative, prosthetics) of the occlusal complex are required., Cilj rada je bio da prikaže istorijsku perspektivu okluzalnog koncepta„long centric"(LC) i njegov značaj u savremenoj stomatologiji, posebno sa gnatološkog aspekta. Koncept LC predstavlja terapijski modalitet koji se koristi u savremenoj stomatologiji i okluzalnom podešavanju kod pacijenata kod kojih se čvrsto i blago zatvaranje donje vilice iz položaja fiziološkog mira razlikuje. LC se odnosi samo na anteriorne zube i na okluzalnu slobodu od centra, a ne u centru. Ako potreba za ovim konceptom nije adekvatno zadovoljena, javlja se okluzalna smetnja zbog tzv. efekta klina u inicijalnom zatvaranju donje vilice. Različiti obrasci abrazije ili nekog stepena hipermobilnosti zuba su često rezultat takve smetnje i mogu imati potencijal „okidača" za bruksizam i parafunkciju. Prikazan modus procedenti određivanja potrebe za LC treba da bude rutinski prilaz svakog lekara bilo kojoj okluziji, jer ugrađen LC efikasno doprinosi okluzalnoj stabilnosti prednjeg segmenta denticije. Sve okluzije bi trebalo rutinski testirati u pogledu potrebe za LC, naročito kada postoji potreba za ekstenzivnim terapijskim intervencijama (konzervativna, protetska) na okluzalnom kompleksu.

Prikazane su dijagnostičke i terapijske mogućnosti videotorakoskopskog (VATS) liječenja recidivnog spontanog pneumotoraksa.

Protezni stomatitis je često oboljenje kod pacijenata koji koriste totalne zubne proteze. Uglavnom protezni stomatitis nije praćen simptomima i pacijenti nisu svesni prisutnog oboljenja. Etiologija proteznog stomatitisa je multifaktorijalna. Kao dominantan faktor ističe se infekcija gljivama roda Candida. Totalne zubne proteze podležu kolonizaciji i formiranju biofilma Candida spp. Protezni plak (biofilm) je sličan dentalnom plaku i služi kao rezervoar potencijalno infektivnih mikroorganizama. Mikroorganizmi iz proteznog plaka, (najviše Candida spp.) su odgovorni za nastanak proteznog stomatitisa. Kontinuirano gutanje mikroorganizama iz proteznog plaka izlaže pacijente riziku od neočekivane infekcije. ajčešća izolovana vrsta gljive na protezama je C. albicans. Prisutni su opšti i lokalni kontributivni faktori. Lokalni faktori su: lezije oralne sluzokože uzrokovane neadekvatnim protezama, neprekidno nošenje zubne proteze, smanjen protok pljuvačke, loša higijena zubne proteze, vrsta materijala od koga je izrađena proteza, starost proteze, slaba retencija proteze, neizbalansirana okluzija. Opšti faktori su: diabetes mellitus, pušenje, dugotrajna primena antibiotika i kortikosteroida, radio i hemoterapija, faktori ishrane – nedostatak vitamina B12, folata i gvožđa, psihotropni lekovi, hiposalivatori. Cilj ovog istraživanja je bio da se pouzdano dijagnostikuje i odredi učestalost proteznog stomatitisa gljivične etiologije i ispita antifungalna aktivnost etarskih ulja. Za potrebe ovog istraživanja dizajniran je poseban upitnik, koji sadrži generalije, medicinsku i stomatološku istoriju i podatke dobijene kliničkim pregledom. Klinički pregled se sastojao od inspekcije usne duplje, na osnovu koga se dijagnostikovala inflamacija mekih tkiva, kao i stepen i lokacija inflamacije. Analizom postojećeg stanja totalne zubne proteze u ustima pacijenta utvrđivan je stepen retencije zubne proteze, očuvanost vertikalne dimenzije okluzije i okluzalni odnosi sa antagonistima. Deo istraživanja je sproveden u laboratoriji... Denture stomatitis is a common disease in patients with dentures. Generally, denture stomatitis is not followed by any symptoms and patients are usually not aware of the disease. Etiology of denture stotmatitis is multifactorial. As a dominant factor is the fungal infection by Candida spp. Complete dentures are susceptible to colonization and biofilm formation of Candida spp. Denture plaque (biofilm) is similar to a dental plaque and it is a reservoir of potential infective microorganisms. Microorganisms in denture plaque, (mostly Candida spp.) are responsible for the emergence of denture stomatitis. A continual swallowing of microorganism from denture plaque exposes patients to a risk of unexpected infection. The most common isolated species of fungus on dentures is C. albicans. There are some general and local contributory factors. The local factors are: trauma of oral mucosa caused by inadequate dentures, continuous dentures wearing, reduced saliva flow, bad dentures hygiene, type of the material dentures are made of, detures’age, poor dentures retention, unbalanced occlusion. The general factors are: diabetes mellitus, smoking, long antibiotics and corticosteroids application and radio or chemotherapy, diet factors, - lack of vitamin B12, foliates and iron, psychotropic medications and hyposalivators. The aim of this research has been to diagnose and designate a frequency of denture stomatitis of fungal etiology and examine antifungal activities of essential oils. For the needs of this research there has been designed a special questionnaire which contains .personal data, medical and stomatological history and data obtained by clinical examination. Clinical examination consisted of inspection of oral cavity on the basis of which a soft tissue inflammation has been diagnosed as well as a degree and location of the inflammation. Analysing the present state of complete dentures in patients’ mouth there has been established a degree of denture retention, preservation of vertical dimension of occlusion and occlusal relations with antagonists...

Bol koji potiče iz mišićno-skeletnih struktura mastikatornog sistema spada u grupu simptoma koji pripadaju kategoriji temporomandibularnih poremećaja ili temporomandibularnih disfunkcija (TMD). Bol u regiji lica, vilica i viličnih zglobova predstavlja najizraženiji i dominantan simptom temporomandibularnih disfunkcija i glavni razlog posete lekaru. Akutni bol je udružen sa kliničkom slikom intenzivnih, naglih i oštrih napada bolnih simptoma kombinovanih sa pratećim disfunkcijama, u kratkom vremenskom periodu. Bol hroničnog toka kod temporomandibularnih disfunkcija se definiše kao sporo napredujući i perzistentni simptom, udružen sa psihološkim faktorima, psihosocijalnim faktorima i faktorima bolnog ponašanja. Postoji značajna povezanost između hroničnog TMD bola i simptoma i znakova depresije, što je karakteristično i za hronične muskuloskeletne poremećaje izvan regije glave i vrata. Kontrola bola u pacijenata sa temporomandibularnim disfunkcijama obuhvata različite terapijske modalitete. Terapija lekovima predstavlja vid dopunske terapije u lečenju bolnih simptoma. Terapija stabilizacionim okluzalnim splintom i terapija lekovima su uobičajene procedure u svakodnevnoj kliničkoj praksi i najčešće se koriste u kontroli bola i redukciji simptoma i znakova temporomandibularnih disfunkcija. Cilj istraživanja je bio da se proceni efekat terapije stabilizacionim okluzalnim splintom kao procedure u kontroli bolnih simptoma TMD u poređenju sa efektom terapije lekovima. Koristeći standardni dijagnostički protokol (RDC/TMD) predložen od strane Dworkin-a i LeResche-a izdvojena je grupa od 44 pacijenta sa bolnim temporomandibularnim disfunkcijama. Pacijenti koji su uključeni u istraživanje su podeljeni u tri terapijske grupe slučajnim izborom. Prva grupa je podvrgnuta terapiji stabilizacionim okluzalnim splintom u vremenskom periodu od mesec dana. U dve kontrolne grupe je sprovedena terapija Ibuprofenom i kombinacijom Ibuprofena i Diazepama u periodu od tri nedelje. U cilju procene efekata terapije stabilizacionim okluzalnim splintom i terapije lekovima, pre i posle sprovedene terapije izvedena su merenja intenziteta bola. Kvantifikacija intenziteta bola izvršena je vizualnom analognom skalom (VAS) i digitalnim pritisnim algometrom. Tokom terapije nisu zabeleženi negativni sporedni efekti. U sve tri terapijske grupe postignuta je značajna redukcija intenziteta bolnih simptoma. Nisu zabeležene značajne razlike u uspešnosti redukcije bola između predloženih terapijskih modaliteta. Dobijeni rezultati potvrđuju da je terapija stabilizacionim okluzalnim splintom validna procedura u redukciji bola u pacijenata sa TMD. Zato se terapija stabilizacionim okluzalnim splintom može preporučiti kao pouzdan i bezbedan metod u kontroli bola orofacijalne regije muskuloskeletnog porekla... Pains that originate from the musculoskeletal structures of the masticatory system belong to sum of complaints that are included in a category of musculoskeletal disorders also known as tempororomandibular disorders (TMD). Pain is the most prominent TMD related symptom. Acute pain is associated with clinical condicions of intensive, rapid and severe pain onset combined with accompanying disturbances over a short time course. Chronic TMD related pain is defined as slowly developed and persistend symptom associated with psychologic, behavioral and psychosocial factors. There is significant relationship between chronic TMD related pain and depressive symptoms, similar to others musculoskeletal chronic pain patients. In a threatment of patients with TMD pain related symptoms there are several therapeutic modalites being used. Pharmacologic therapy can be effective adjunct in managing TMD pain related symptoms. Both occlusal apliance therapy and pharmacotherapy are customary in clinical practice and the most commonly used modalites in TMD pain reducing. The goal of this study is to assess the stabilization appliance therapy as a reliable procedure in reducing TMD related pain comparing with pharmacotherapy procedures. Using standarsided diagnostic protocol called Research Diagnostic Criteria for TMD (RDC/TMD) provided by Dworkin and LeResche a group of 44 patients with TMD related pain complains were singled out. After the chosen patients inlisted they were divided into three groups by random. The first group involved was subjected to stabilization appliance therapy in one month time duration. Two control groups were treated by Ibuprofen or Ibuprofen and Diazepam drug combination, respectively, in tree weeks time period. In order to evaluate effects both stabilization appliance and pharmacotherapy before and after proposed therapy we conducted measurements of intensity TMD related pain symptoms. For quantification of pain intensity prior to and after therapy both Visual Analogue Scale and digital pressure algometer were used. During the treatment serious side effect were not observed. In all three groups we achived notable pain reducing. There was no significally differenses in pain reducing sucsess between proposed modalites. Obtained results confirming the fact that occlisal stabilization appliance therapy to be valid therapeutic procedure in TMD pain reducing. Therefore, it should be recomended as useful and safe method in TMD pain therapy...

Pains that originate from the musculoskeletal structures of the masticatory system belong to sum of complaints that are included in a category of musculoskeletal disorders also known as tempororomandibular disorders (TMD). Pain is the most prominent TMD related symptom. Acute pain is associated with clinical condicions of intensive, rapid and severe pain onset combined with accompanying disturbances over a short time course. Chronic TMD related pain is defined as slowly developed and persistend symptom associated with psychologic, behavioral and psychosocial factors. There is significant relationship between chronic TMD related pain and depressive symptoms, similar to others musculoskeletal chronic pain patients. In a threatment of patients with TMD pain related symptoms there are several therapeutic modalites being used. Pharmacologic therapy can be effective adjunct in managing TMD pain related symptoms. Both occlusal apliance therapy and pharmacotherapy are customary in clinical practice and the most commonly used modalites in TMD pain reducing. The goal of this study is to assess the stabilization appliance therapy as a reliable procedure in reducing TMD related pain comparing with pharmacotherapy procedures. Using standarsided diagnostic protocol called Research Diagnostic Criteria for TMD (RDC/TMD) provided by Dworkin and LeResche a group of 44 patients with TMD related pain complains were singled out. After the chosen patients inlisted they were divided into three groups by random. The first group involved was subjected to stabilization appliance therapy in one month time duration. Two control groups were treated by Ibuprofen or Ibuprofen and Diazepam drug combination, respectively, in tree weeks time period. In order to evaluate effects both stabilization appliance and pharmacotherapy before and after proposed therapy we conducted measurements of intensity TMD related pain symptoms. For quantification of pain intensity prior to and after therapy both Visual Analogue Scale and digital pressure algometer were used. During the treatment serious side effect were not observed. In all three groups we achived notable pain reducing. There was no significally differenses in pain reducing sucsess between proposed modalites. Obtained results confirming the fact that occlisal stabilization appliance therapy to be valid therapeutic procedure in TMD pain reducing. Therefore, it should be recomended as useful and safe method in TMD pain therapy..., Bol koji potiče iz mišićno-skeletnih struktura mastikatornog sistema spada u grupu simptoma koji pripadaju kategoriji temporomandibularnih poremećaja ili temporomandibularnih disfunkcija (TMD). Bol u regiji lica, vilica i viličnih zglobova predstavlja najizraženiji i dominantan simptom temporomandibularnih disfunkcija i glavni razlog posete lekaru. Akutni bol je udružen sa kliničkom slikom intenzivnih, naglih i oštrih napada bolnih simptoma kombinovanih sa pratećim disfunkcijama, u kratkom vremenskom periodu. Bol hroničnog toka kod temporomandibularnih disfunkcija se definiše kao sporo napredujući i perzistentni simptom, udružen sa psihološkim faktorima, psihosocijalnim faktorima i faktorima bolnog ponašanja. Postoji značajna povezanost između hroničnog TMD bola i simptoma i znakova depresije, što je karakteristično i za hronične muskuloskeletne poremećaje izvan regije glave i vrata. Kontrola bola u pacijenata sa temporomandibularnim disfunkcijama obuhvata različite terapijske modalitete. Terapija lekovima predstavlja vid dopunske terapije u lečenju bolnih simptoma. Terapija stabilizacionim okluzalnim splintom i terapija lekovima su uobičajene procedure u svakodnevnoj kliničkoj praksi i najčešće se koriste u kontroli bola i redukciji simptoma i znakova temporomandibularnih disfunkcija. Cilj istraživanja je bio da se proceni efekat terapije stabilizacionim okluzalnim splintom kao procedure u kontroli bolnih simptoma TMD u poređenju sa efektom terapije lekovima. Koristeći standardni dijagnostički protokol (RDC/TMD) predložen od strane Dworkin-a i LeResche-a izdvojena je grupa od 44 pacijenta sa bolnim temporomandibularnim disfunkcijama. Pacijenti koji su uključeni u istraživanje su podeljeni u tri terapijske grupe slučajnim izborom. Prva grupa je podvrgnuta terapiji stabilizacionim okluzalnim splintom u vremenskom periodu od mesec dana. U dve kontrolne grupe je sprovedena terapija Ibuprofenom i kombinacijom Ibuprofena i Diazepama u periodu od tri nedelje. U cilju procene efekata terapije stabilizacionim okluzalnim splintom i terapije lekovima, pre i posle sprovedene terapije izvedena su merenja intenziteta bola. Kvantifikacija intenziteta bola izvršena je vizualnom analognom skalom (VAS) i digitalnim pritisnim algometrom. Tokom terapije nisu zabeleženi negativni sporedni efekti. U sve tri terapijske grupe postignuta je značajna redukcija intenziteta bolnih simptoma. Nisu zabeležene značajne razlike u uspešnosti redukcije bola između predloženih terapijskih modaliteta. Dobijeni rezultati potvrđuju da je terapija stabilizacionim okluzalnim splintom validna procedura u redukciji bola u pacijenata sa TMD. Zato se terapija stabilizacionim okluzalnim splintom može preporučiti kao pouzdan i bezbedan metod u kontroli bola orofacijalne regije muskuloskeletnog porekla...