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410 results on '"Martinho, Ricardo"'

1. Online Sport Infrastructure Management for the Sustainability: Football, Futsal, and Beach Football

Author

Gomes, Ricardo, Martinho, Ricardo, Gonçalves, Alexandrino, Pereira, Vitor, Brito, Sandro, Monteiro, Luis, Vieira, Júlio, Nunes, Manuel, Bezaeva, Natalia S., Series Editor, Gomes Coe, Heloisa Helena, Series Editor, Nawaz, Muhammad Farrakh, Series Editor, Galvão, João Rafael da Costa Sanches, editor, Brito, Paulo, editor, Neves, Filipe dos Santos, editor, Almeida, Henrique de Amorim, editor, Mourato, Sandra de Jesus Martins, editor, and Nobre, Catarina, editor

Published
2024
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2. 2ARTs: A Platform for Exercise Prescriptions in Cardiac Recovery Patients

Author

Pereira, Andreia, Martinho, Ricardo, Pinto, Rui, Rijo, Rui, Grilo, Carlos, Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, Daimi, Kevin, editor, and Al Sadoon, Abeer, editor

Published
2024
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9. Improving MRI's slice selectivity in the presence of strong, metal-derived inhomogeneities

Author

Farkash, Gil, Liberman, Gilad, Martinho, Ricardo P., and Frydman, Lucio

Subjects
Physics - Medical Physics
Abstract

Purpose: To develop schemes that deliver faithful 2D slices near field heterogeneities of the kind arising from non-ferromagnetic metal implants, with reduced artifacts and shorter scan times. Methods: An excitation scheme relying on cross-term spatio-temporal encoding (xSPEN) was used as basis for developing the new inhomogeneity-insensitive, slice-selective pulse scheme. The resulting Fully refOCUSED cross-term SPatiotemporal ENcoding (FOCUSED-xSPEN) approach involved four adiabatic sweeps. The method was evaluated in silico, in vitro and in vivo using mice models, and compared against a number of existing and of novel alternatives based on both conventional and swept RF pulses, including an analogous method based on LASER's selectivity spatial selectivity. Results: Calculations and experiments confirmed that multi-sweep derivatives of xSPEN and LASER can deliver localized excitation profiles, centered at the intended positions and endowed with enhanced immunity to B0 and B1 distortions. This, however, is achieved at the expense of higher SAR than non-swept counterparts. Furthermore, single-shot FOCUSED-xSPEN and LASER profiles covered limited off-resonance ranges. This could be extended to bands covering arbitrary off-resonance values with uniform slice widths, by looping the experiments over a number of scans possessing suitable transmission and reception offsets. Conclusions: A series of novel approaches were introduced to select slices near metals, delivering robustness against Bo and B1+ field inhomogeneities., Comment: 7 figures, 9 figures in the supporting information

Published
2020
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13. Prescribe and Monitor Physical Activity Through a Community-Based eHealth Program: MOVIDA Platform

Author

Fonseca-Pinto, Rui, Rijo, Rui, Assunção, Pedro, Seco, Maria Alexandra, Guarino, Maria P., Braga-Pontes, Cátia, Gomes, Dulce, Carreira, Bruno, Correia, Pedro, Oliveira, Luís, Pires, Gabriel, Leitão, Catarina, Antunes, Alexandre, Januário, Filipa, Martinho, Ricardo, Magjarevic, Ratko, Series Editor, Ładyżyński, Piotr, Associate Editor, Ibrahim, Fatimah, Associate Editor, Lackovic, Igor, Associate Editor, Rock, Emilio Sacristan, Associate Editor, Badnjevic, Almir, editor, Škrbić, Ranko, editor, and Gurbeta Pokvić, Lejla, editor

Published
2020
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18. Water Confinement on Polymer Coatings Dictates Proton–Electron Transfer on Metal-Catalyzed Hydrogenation of Nitrite

Author

Huang, Pengcheng, Yan, Yu, Martinho, Ricardo P., Lefferts, Leon, Wang, Bin, and Faria Albanese, Jimmy

Abstract

Enzymes can precisely control the speed and selectivity of chemical reactions by modifying locally the solvent–reactant interactions. To extrapolate these attributes to heterogeneous catalysts, we have employed thermoresponsive poly n-isopropylacrylamide (p-NIPAM) brushes bonded to silica spheres containing palladium. These polymers can form hydrogen bonds with water molecules at low temperatures (<32 °C) allowing the polymer to stay swollen. Detailed reaction kinetics of nitrite hydrogenation showed that p-NIPAM decreases the apparent activation barrier by a factor of 3 at low temperatures. Diffusion-ordered spectroscopy nuclear magnetic resonance and ab initio molecular dynamics simulations showed that when p-NIPAM is present, water molecules near the surface are less mobile. This confinement perturbs the water interaction with the metal, reducing the barrier for the proton–electron transfer reduction of nitrite. Notably, this enhancement vanishes at high temperature as the polymer collapses on itself exposing the Pd to unconfined water. The fully reversible nature of this process opens the door for creating homeostatic catalysts with controlled water-confinement.

Published
2024
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20. Cover Image, Volume 36, Issue 11

Author

Montrazi, Elton T., primary, Bao, Qingjia, additional, Martinho, Ricardo P., additional, Peters, Dana C., additional, Harris, Talia, additional, Sasson, Keren, additional, Agemy, Lilach, additional, Scherz, Avigdor, additional, and Frydman, Lucio, additional

Published
2023
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22. Reliability of AAL Systems Modeled as BPMN Business Processes

Author

Respício, Ana, Martinho, Ricardo, Domingos, Dulce, van der Aalst, Wil M.P., Series editor, Mylopoulos, John, Series editor, Rosemann, Michael, Series editor, Shaw, Michael J., Series editor, Szyperski, Clemens, Series editor, Hammoudi, Slimane, editor, Maciaszek, Leszek A., editor, Missikoff, Michele M., editor, Camp, Olivier, editor, and Cordeiro, José, editor

Published
2017
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31. Modeling Emergency Care Process Taking into Account Its Flexibility

Author

Mejri, Asma, Ayachi Ghannouchi, Sonia, Martinho, Ricardo, van der Aalst, Wil M.P., Series editor, Mylopoulos, John, Series editor, Rosemann, Michael, Series editor, Shaw, Michael J., Series editor, Szyperski, Clemens, Series editor, Díaz, Paloma, editor, Bellamine Ben Saoud, Narjès, editor, Dugdale, Julie, editor, and Hanachi, Chihab, editor

Published
2016
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40. Flexibility-based selection of paradigms and tools for BP modelling and execution

Author

Mejri, Asma, Ghannouchi, Sonia Ayachi, and Martinho, Ricardo

Abstract

The last decades have witnessed several changes at the level of the development and the adoption of several business process management approaches, methodologies, tools and paradigms. These latter support all stages of the business process management life-cycle. Due to the continuous, increasing and rapid changes in the context or environment in which organisations operate, flexibility of business processes ranks high on the list of priorities of organisations. Hence, organisations must be able to respond promptly and effectively to these changes and unexpected turbulence. This research presents a generic approach for guiding business process engineers to choose paradigms and tools, for modelling and executing their business process, in the sense of taking into account their flexibility requirements. A case study is conducted considering the well-known Scrum framework as a business process for which the approach is applied. Business processes are analysed in terms of flexibility needs, and then our approach guides process engineers on the modelling paradigm and tools they can use accordingly.

Published
2024
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41. Deuterium imaging of the Warburg effect at sub‐millimolar concentrations by joint processing of the kinetic and spectral dimensions.

Author

Montrazi, Elton T., Bao, Qingjia, Martinho, Ricardo P., Peters, Dana C., Harris, Talia, Sasson, Keren, Agemy, Lilach, Scherz, Avigdor, and Frydman, Lucio

Subjects
WARBURG Effect (Oncology), DEUTERIUM, SPECTRAL sensitivity, SPECTROSCOPIC imaging, COMPRESSED sensing
Abstract

Deuterium metabolic imaging (DMI) is a promising molecular MRI approach, which follows the administration of deuterated substrates and their metabolization. [6,6'‐2H2]‐glucose for instance is preferentially converted in tumors to [3,3'‐2H2]‐lactate as a result of the Warburg effect, providing a distinct resonance whose mapping using time‐resolved spectroscopic imaging can diagnose cancer. The MR detection of low‐concentration metabolites such as lactate, however, is challenging. It has been recently shown that multi‐echo balanced steady‐state free precession (ME‐bSSFP) increases the signal‐to‐noise ratio (SNR) of these experiments approximately threefold over regular chemical shift imaging; the present study examines how DMI's sensitivity can be increased further by advanced processing methods. Some of these, such as compressed sensing multiplicative denoising and block‐matching/3D filtering, can be applied to any spectroscopic/imaging methods. Sensitivity‐enhancing approaches were also specifically tailored to ME‐bSSFP DMI, by relying on priors related to the resonances' positions and to features of the metabolic kinetics. Two new methods are thus proposed that use these constraints for enhancing the sensitivity of both the spectral images and the metabolic kinetics. The ability of these methods to improve DMI is evidenced in pancreatic cancer studies carried at 15.2 T, where suitable implementations of the proposals imparted eightfold or more SNR improvement over the original ME‐bSSFP data, at no informational cost. Comparisons with other propositions in the literature are briefly discussed. [ABSTRACT FROM AUTHOR]

Published
2023
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43. Preface

Author

Cruz-Cunha, Maria Manuela, primary, Martinho, Ricardo, additional, Rijo, Rui, additional, Domingos, Dulce, additional, and Peres, Emanuel, additional

Published
2023
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44. High‐field ex vivo and in vivo two‐dimensional nuclear magnetic resonance spectroscopy in murine brain: Resolving and exploring the molecular environment

Author

Martinho, Ricardo P., Jain, Mukul G., and Frydman, Lucio

Subjects
Molecular Medicine, Radiology, Nuclear Medicine and imaging, Spectroscopy
Abstract

The structural and chemical complexities within the brain pose a challenge that few noninvasive techniques can tackle with the dexterity of nuclear magnetic resonance (NMR) spectroscopy. Still, even with the advent of ultrahigh fields and of cryogenically cooled coils for in vivo research, the superposition of metabolic resonances arising from the brain remains a challenge. The present study explores the potential to tackle this milieu using a combination of two-dimensional (2D) NMR techniques, implemented on murine brains in vivo at 15.2 T and ex vivo at 14.1 T. While both experiments were affected by substantial inhomogeneous broadenings conveying distinct elongated lineshapes to the cross-peaks, the ability of increased fields to resolve off-diagonal resonances was clear. A comparison between the corresponding conventional and double quantum-filtered correlated spectroscopy traces enabled an improved assignment of in vivo resonances on the basis of more sensitive ex vivo 2D acquisitions, foremost on the basis of homonuclear cross-relaxation-driven correlations for peaks resonating downfield from water, and of heteronuclear correlations at natural abundance for the upfield protons. With the aid of such 2D correlations approximately 29 metabolites could be resolved and identified. This enhanced resolution was used to explore features related to the metabolites' diffusivities, their exposure to water, and their facility to undergo magnetization transfers to amide/amine/hydroxyl resonances. Cross-peaks from main murine brain biomolecules, including choline, creatine, γ-aminobutyric acid, N-acetyl aspartate, glutamine, and glutamate, showed enhancements in several of these various features, opening interesting vistas about metabolite compartmentalization as viewed by these 2D NMR experiments.

Published
2022

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