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1. Metabolic syndrome in hemodialysis patients as a risk factor for new-onset diabetes mellitus after renal transplant: a prospective observational study

Author

Bonet J, Martinez-Castelao A, and Bayés B

Subjects
Specialties of internal medicine, RC581-951
Abstract

Josep Bonet1, Albert Martinez-Castelao2, Beatriz Bayés11Department of Nephrology, Hospital Universitari Germans Trias i Pujol, Badalona, Spain; 2Department of Nephrology, Hospital Universitari de Bellvitge, IDIBELL, Hospitalet de Llobregat, Barcelona, SpainPurpose: Metabolic syndrome is a cluster of biochemical abnormalities including cardiovascular and diabetes risk factors. The development of diabetes mellitus after renal transplant represents a major posttransplant complication that may adversely affect graft/patient survival. The aim of this study was to assess the role of metabolic syndrome in patients on hemodialysis as a risk factor for the incidence of new-onset diabetes mellitus after renal transplant.Patients and methods: This was a prospective observational epidemiologic study carried out in adult nondiabetic patients undergoing chronic hemodialysis and on the renal transplant waiting list between November 2008 and April 2009. Patients were followed up from Visit 1 (baseline) to 6 months after the renal transplant. The analysis of the role of metabolic syndrome in hemodialysis patients as a risk factor for the incidence of new-onset diabetes mellitus after renal transplant included the estimation of relative risk and its 95% confidence interval (CI).Results: A total of 383 evaluable patients were entered into the study (mean age, 52.7 years; male, 57.7%; Caucasian, 90.1%). The prevalence of metabolic syndrome on hemodialysis was 30.4% (95% CI, 25.8%–35.4%). Hypertension was the most prevalent criterion for metabolic syndrome (65.0%), followed by low levels of high-density lipoprotein cholesterol (52.7%), abdominal obesity (36.2%), hypertriglyceridemia (32.4%), and impaired glucose (8.9%). After the renal transplant, the prevalence of metabolic syndrome was still 25.8%. During the posttransplant period, the incidence of new-onset diabetes mellitus reached 13.0% (95% CI, 7.8%–20.6%) and patients with pretransplant metabolic syndrome were 2.6 times (95% CI, 1.043–6.608) more likely to develop new-onset diabetes mellitus after the renal transplant than those without metabolic syndrome.Conclusion: The presence of metabolic syndrome in patients undergoing hemodialysis represents an independent risk factor for the incidence of new-onset diabetes mellitus after renal transplant.Keywords: dialysis, kidney transplantation, metabolic syndrome X, posttransplant diabetes

Published
2013

2. Factores de progresión en pacientes con ERC-3 KDOQI (estudio PROGRESER)

Author

Martínez-Castelao, Alberto, Górriz Teruel, José Luis, Marco, Luis D., Garrigós, Enrique, Fernández-Fresnedo, Gema, Espinel Garuz, Eugenia, Cigarrán Guldris, Secundino, Arteaga Coloma, Jesús, Robles Pérez-Monteoliva, Nicolas Roberto, Esteban De la Rosa, Rafael José, Nieto Iglesias, Luis Javier, Ortiz Arduán, Alberto, and Navarro-González, Juan Francisco

Published
2024
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3. A randomized multicenter trial on a lung ultrasound–guided treatment strategy in patients on chronic hemodialysis with high cardiovascular risk

Author

Zoccali, Carmine, Torino, Claudia, Mallamaci, Francesca, Sarafidis, Pantelis, Papagianni, Aikaterini, Ekart, Robert, Hojs, Radovan, Klinger, Marian, Letachowicz, Krzysztof, Fliser, Danilo, Seiler-Mußler, Sarah, Lizzi, Fabio, Wiecek, Andrzej, Miskiewicz, Agata, Siamopoulos, Kostas, Balafa, Olga, Slotki, Itzchak, Shavit, Linda, Stavroulopoulos, Aristeidis, Covic, Adrian, Siriopol, Dimitrie, Massy, Ziad A., Seidowsky, Alexandre, Battaglia, Yuri, Martinez-Castelao, Alberto, Polo-Torcal, Carolina, Coudert-Krier, Marie-Jeanne, Rossignol, Patrick, Fiaccadori, Enrico, Regolisti, Giuseppe, Hannedouche, Thierry, Bachelet, Thomas, Jager, Kitty J., Dekker, Friedo W., Tripepi, Rocco, Tripepi, Giovanni, Gargani, Luna, Sicari, Rosa, Picano, Eugenio, and London, Gérard Michel

Published
2021
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4. Inflammation is an amplifier of lung congestion by high lv filling pressure in hemodialysis patients: a longitudinal study

Author

Torino, Claudia, Gargani, Luna, Sicari, Rosa, Letachowicz, Krzysztof, Ekart, Robert, Fliser, Danilo, Covic, Adrian, Siamopoulos, Kostas, Stavroulopoulos, Aristeidis, Massy, Ziad A., Fiaccadori, Enrico, Regolisti, Giuseppe, Bachelet, Thomas, Slotki, Itzchak, Martinez-Castelao, Alberto, Coudert-Krier, Marie-Jeanne, Rossignol, Patrick, Hannedouche, Thierry, Wiecek, Andrzej, Sarafidis, Pantelis, Battaglia, Yuri, Prohić, Nejra, Klinger, Marian, Hojs, Radovan, Seiler-Mußler, Sarah, Lizzi, Fabio, Siriopol, Dimitrie, Balafa, Olga, Shavit, Linda, Loutradis, Charalampos, Seidowsky, Alexandre, Tripepi, Rocco, Mallamaci, Francesca, Tripepi, Giovanni, Picano, Eugenio, London, Gérard Michel, and Zoccali, Carmine

Published
2020
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5. Estimated Glomerular Filtration Rate, Cardiovascular Events and Mortality Across Age Groups Among Individuals Older Than 60 Years in Southern Europe

Author

Salvador-González, Betlem, Gil-Terrón, Neus, Cerain-Herrero, M. Jesús, Subirana, Isaac, Güell-Miró, Roser, Rodríguez-Latre, Luisa M., Cunillera-Puértolas, Oriol, Elosua, Roberto, Grau, Maria, Vila, Joan, Pascual-Benito, Luisa, Mestre-Ferrer, Jordi, Ramos, Rafel, Baena-Díez, José Miguel, Soler-Vila, Maria, Alonso-Bes, Eva, Ruipérez-Guijarro, Laura, Álvarez-Funes, Virtudes, Freixes-Villaró, Esther, Rodríguez-Pascual, Mercedes, and Martínez-Castelao, Alberto

Published
2018
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8. Mineral metabolism disorders, vertebral fractures and aortic calcifications in stable kidney transplant recipients: The role of gender (EMITRAL study)

Author

Torres, Armando, Torregrosa, Vicens, Marcen, Roberto, Campistol, Josep María, Arias, Manuel, Hernández, Domingo, Fernández, Constantino, Esforzado, Nuria, Paschoalin, Raphael, Pérez, Nuria, García, Ana Isabel, Del Amo, Montserrat, Pomés, Jaume, González Rinne, Ana, Marrero, Domingo, Pérez, Estefanía, Henríquez, Fernando, Díaz, Juan Manuel, Silva, Irene, López, Verónica, Perello, Manuel, Ramos, David, Beneyto, Isabel, Cruzado, José María, Martínez Castelao, Alberto, Bravo, Juan, Rodríguez, Minerva, Díaz, Carmen, Crespo, Josep, Anaya, Fernando, Rodríguez, María Luisa, Cubero, Juan José, Pascual, Pilar, Romero, Rafael, Andrés Belmonte, Amado, Checa, María Dolores, Jiménez, Carlos, Escuin, Fernando, Crespo, Marta, Mir, Marisa, Gómez, Gonzalo, Bayes, Beatriz, González, María José, Gutiérrez, Alex, Cuberes, Marta, Rodríguez Benoit, Alberto, García, Teresa, Llamas, Francisco, Ortega, Agustín, Conde, José Luis, and Gómez Alamillo, Carlos

Published
2016
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11. Inflammation is an amplifier of lung congestion by high lv filling pressure in hemodialysis patients: a longitudinal study

Author

Torino, Claudia, Gargani, Luna, Sicari, Rosa, Letachowicz, Krzysztof, Ekart, Robert, Fliser, Danilo, Covic, Adrian, Siamopoulos, Kostas, Stavroulopoulos, Aristeidis, Massy, Ziad A., Fiaccadori, Enrico, Regolisti, Giuseppe, Bachelet, Thomas, Slotki, Itzchak, Martinez-Castelao, Alberto, Coudert-Krier, Marie-Jeanne, Rossignol, Patrick, Hannedouche, Thierry, Wiecek, Andrzej, Sarafidis, Pantelis, Battaglia, Yuri, Prohić, Nejra, Klinger, Marian, Hojs, Radovan, Seiler-Mußler, Sarah, Lizzi, Fabio, Siriopol, Dimitrie, Balafa, Olga, Shavit, Linda, Loutradis, Charalampos, Seidowsky, Alexandre, Tripepi, Rocco, Mallamaci, Francesca, Tripepi, Giovanni, Picano, Eugenio, London, Gérard Michel, and Zoccali, Carmine

Abstract

Introduction: Since inflammation alters vascular permeability, including vascular permeability in the lung, we hypothesized that it can be an amplifier of lung congestion in a category of patients at high risk for pulmonary oedema like end stage kidney disease (ESKD) patients. Objective and methods: We investigated the effect modification by systemic inflammation (serum CRP) on the relationship between a surrogate of the filling pressure of the LV [left atrial volume indexed to the body surface area (LAVI)] and lung water in a series of 220 ESKD patients. Lung water was quantified by the number of ultrasound B lines (US-B) on lung US. Six-hundred and three recordings were performed during a 2-year follow up. Longitudinal data analysis was made by the Mixed Linear Model. Results: At baseline, 88 had absent, 101 had mild to moderate lung congestion and 31 severe congestion. The number of US B lines associated with LAVI (r= 0.23, P< 0.001) and serum CRP was a robust modifier of this relationship (P< 0.001). Similarly, in fully adjusted longitudinal analyses US-B lines associated with simultaneous estimates of LAVI (P= 0.002) and again CRP was a strong modifier of this relationship in adjusted analyses (P≤ 0.01). Overall, at comparable LAVI levels, lung congestion was more pronounced in inflamed than in non-inflamed patients. Conclusion: In ESKD systemic inflammation is a modifier of the relationship between LAVI, an integrate measure of LV filling pressure, and lung water. For any given pressure, lung water is increased with higher CRP levels, likely reflecting a higher permeability of the alveolar-capillary barrier.

Published
2024
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13. Documento de consenso para la detección y manejo de la enfermedad renal crónica

Author

Martínez-Castelao, Alberto, Górriz, José L., Bover, Jordi, Segura-de la Morena, Julián, Cebollada, Jesús, Escalada, Javier, Esmatjes, Enric, Fácila, Lorenzo, Gamarra, Javier, Gràcia, Silvia, Hernández-Moreno, Julio, Llisterri-Caro, José L., Mazón, Pilar, Montañés, Rosario, Morales-Olivas, Francisco, Muñoz-Torres, Manuel, de Pablos-Velasco, Pedro, de Santiago, Ana, Sánchez-Celaya, Marta, Suárez, Carmen, and Tranche, Salvador

Published
2014
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14. Resumen ejecutivo del documento de consenso sobre el manejo de la patología renal en pacientes con infección por el virus de la inmunodeficiencia humana

Author

Gorriz, José L., Gutiérrez, Félix, Trullàs, Joan C., Arazo, Piedad, Arribas, Jose R., Barril, Guillermina, Cervero, Miguel, Cofán, Frederic, Domingo, Pere, Estrada, Vicente, Fulladosa, Xavier, Galindo, María J., Gràcia, Sílvia, Iribarren, José A., Knobel, Hernando, López-Aldeguer, José, Lozano, Fernando, Martínez-Castelao, Alberto, Martínez, Esteban, Mazuecos, Maria A., Miralles, Celia, Montañés, Rosario, Negredo, Eugenia, Palacios, Rosario, Pérez-Elías, María J., Portilla, Joaquín, Praga, Manuel, Quereda, Carlos, Rivero, Antonio, Santamaría, Juan M., Sanz, José, Sanz, Jesús, and Miró, José M.

Published
2014
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15. A randomized multicenter trial on a lung ultrasound-guided treatment strategy in patients on chronic hemodialysis with high cardiovascular risk see commentary

Author

Zoccali, C., Torino, C., Mallamaci, F., Sarafidis, P., Papagianni, A., Ekart, R., Hojs, R., Klinger, M., Letachowicz, K., Fliser, D., Seiler-Mussler, S., Lizzi, F., Wiecek, A., Miskiewicz, A., Siamopoulos, K., Balafa, O., Slotki, I., Shavit, L., Stavroulopoulos, A., Covic, A., Siriopol, D., Massy, Z.A., Seidowsky, A., Battaglia, Y., Martinez-Castelao, A., Polo-Torcal, C., Coudert-Krier, M.J., Rossignol, P., Fiaccadori, E., Regolisti, G., Hannedouche, T., Bachelet, T., Jager, K.J., Dekker, F.W., Tripepi, R., Tripepi, G., Gargani, L., Sicari, R., Picano, E., and London, G.M.

Subjects
cardiovascular risk, lung congestion, heart failure hemodialysis, chronic kidney failure, ESRD, lung ultrasound
Abstract

Lung congestion is a risk factor for all-cause and cardiovascular mortality in patients on chronic hemodialysis, and its estimation by ultrasound may be useful to guide ultrafiltration and drug therapy in this population. In an international, multi-center randomized controlled trial (NCT02310061) we investigated whether a lung ultrasound-guided treatment strategy improved a composite end point (all-cause death, non-fatal myocardial infarction, decompensated heart failure) vs usual care in patients receiving chronic hemodialysis with high cardiovascular risk. Patient-Reported Outcomes (Depression and the Standard Form 36 Quality of Life Questionnaire, SF36) were assessed as secondary outcomes. A total of 367 patients were enrolled: 183 in the active arm and 180 in the control arm. In the active arm, the pre-dialysis lung scan was used to titrate ultrafiltration during dialysis and drug treatment. Three hundred and seven patients completed the study: 152 in the active arm and 155 in the control arm. During a mean follow-up of 1.49 years, lung congestion was significantly more frequently relieved in the active (78%) than in the control (56%) arm and the intervention was safe. The primary composite end point did not significantly differ between the two study arms (Hazard Ratio 0.88; 95% Confidence Interval: 0.63-1.24). The risk for all-cause and cardiovascular hospitalization and the changes of left ventricular mass and function did not differ among the two groups. A post hoc analysis for recurrent episodes of decompensated heart failure (0.37; 0.15-0.93) and cardiovascular events (0.63; 0.41-0.97) showed a risk reduction for these outcomes in the active arm. There were no differences in patientreported outcomes between groups. Thus, in patients on chronic hemodialysis with high cardiovascular risk, a treatment strategy guided by lung ultrasound effectively relieved lung congestion but was not more effective than usual care in improving the primary or secondary end points of the trial.

Published
2021

19. CKD EPIDEMIOLOGY

Author

Gorriz, Jose L., Molina-Vila, Pablo, Nieto, Javier, Bover, Jordi, Martinez-Castelao, Alberto, Martinde Francisco, Angel L., Barril, Guillermina, Del Pino, Maria D., and Escudero, Verónica

Published
2014

20. Assessment of arterial stiffness for clinical and epidemiological studies: methodological considerations for validation and entry into the European Renal and Cardiovascular Medicine registry

Author

Boutouyrie, Pierre, Fliser, Danilo, Goldsmith, David, Covic, Adrian, Wiecek, Andrzej, Ortiz, Alberto, Martinez-Castelao, Alberto, Lindholm, Bengt, Massy, Ziad A., Suleymanlar, Gultekin, Sicari, Rosa, Gargani, Luna, Parati, Gianfranco, Mallamaci, Francesca, Zoccali, Carmine, and London, Gerard M.

Published
2014
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21. MO250URINARY DICKKOPF-3 (UDKK3): A NEW BIOMARKER FOR LONG-TERM CKD PROGRESSION AND MORTALITY?*

Author

Sanchez Alamo, Beatriz, primary, Garcia Iñigo, Francisco Jose, additional, Shabaka, Amir, additional, Acedo, Juan Manuel, additional, Cases Corona, Clara Maria, additional, Dominguez Torres, Patricia, additional, Martinez-Castelao, Alberto, additional, Navarro-González, Juan F, additional, Gorriz Teruel, Jose Luis, additional, and Fernandez Juarez, Gema Maria, additional

Published
2021
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22. Assessing the Limits in Kidney Transplantation: Use of Extremely Elderly Donors and Outcomes in Elderly Recipients

Author

Arcos, E, Perez-Saez, MJ, Comas, J, Lloveras, J, Tort, J, Pascual, J, Martinez-Castelao, A, Troya, M, Cases, A, Calabia, J, Cao, H, Segarra, A, Martinez-Vea, A, Gil-Vernet, S, Espinel, E, Lara, E, and Diaz, JM

Abstract

Background. Patient survival with end-stage renal disease is longer after kidney transplantation (KT) compared with those remaining on dialysis. Nevertheless, this remains uncertain when receiving a kidney from a donor >= 80 years old. Methods. In a longitudinal mortality study in the Catalan Renal Registry including 2585 patients >= 60 years old on dialysis and placed on the KT waiting list, 1084 received a first KT from a deceased donor aged 60 to 79 years and 128 from a deceased donor >= 80 years. We calculated adjusted risk of graft loss by means of competing-risks regression, considering patient death with functioning graft as a competing event. To assess patient survival benefit from KT, we calculated the adjusted risk of death by nonproportional hazard analysis, taking the fact of being transplanted as a time-dependent effect. Considering all KT >= 60 (n = 1212), we assessed whether the benefit of KT varied per different recipient characteristics by calculating the interaction effect between all potential mortality risk factors and the treatment group. Results. Compared with kidneys from donors 60 to 79 years old, graft survival was significantly lower for kidneys from donors aged >= 80 years (subhazard ratio = 1.55; 95% confidence interval, 1.00-2.38; P = 0.048). In comparison with those who remained on dialysis, adjusted risk of death 12 months after transplantation in recipients with a kidney from donors >= 80 years was 0.54 (95% confidence interval, 0.38-0.77; P < 0.0001). Conclusions. Despite KT from octogenarian deceased donors being associated with reduced graft survival, recipients had lower mortality rates than those remaining on dialysis, even if the kidney came from an extremely aged donor.

Published
2020

23. GLP-1 Receptor Agonists and Diabetic Kidney Disease: A Call of Attention to Nephrologists

Author

Gorriz J, Soler M, Navarro-Gonzalez J, Garcia-Carro C, Puchades M, D'Marco L, Martinez Castelao A, Fernandez-Fernandez B, Ortiz A, Gorriz-Zambrano C, Navarro-Perez J, and Gorgojo-Martinez J

Subjects
GLP-1, chronic kidney disease, diabetic kidney disease, urologic and male genital diseases
Abstract

Type 2 diabetes mellitus (T2DM) represents the main cause of chronic kidney disease (CKD) and end-stage renal disease (ESKD), and diabetic kidney disease (DKD) is a major cause of morbidity and mortality in diabetes. Despite advances in the nephroprotective treatment of T2DM, DKD remains the most common complication, driving the need for renal replacement therapies (RRT) worldwide, and its incidence is increasing. Until recently, prevention of DKD progression was based around strict blood pressure (BP) control, using renin-angiotensin system blockers that simultaneously reduce BP and proteinuria, adequate glycemic control and control of cardiovascular risk factors. Glucagon-like peptide-1 receptor agonists (GLP-1RA) are a new class of anti-hyperglycemic drugs shown to improve cardiovascular and renal events in DKD. In this regard, GLP-1RA offer the potential for adequate glycemic control in multiple stages of DKD without an increased risk of hypoglycemia, preventing the onset of macroalbuminuria and slowing the decline of glomerular filtration rate (GFR) in diabetic patients, also bringing additional benefit in weight reduction, cardiovascular and other kidney outcomes. Results from ongoing trials are pending to assess the impact of GLP-1RA treatments on primary kidney endpoints in DKD.

Published
2020

24. Sodium-glucose cotransporter 2 inhibition: towards an indication to treat diabetic kidney disease

Author

Gorriz J, Navarro-Gonzalez J, Ortiz A, Vergara A, Nunez J, Jacobs-Cacha C, Martinez-Castelao A, and Soler M

Subjects
chronic renal failure, type 2 diabetes, ESRD, diabetic kidney disease, SGLT2 inhibitors
Abstract

Sodium-glucose cotransporter 2 inhibitors (SGLT2i) have clearly demonstrated their beneficial effect in diabetic kidney disease (DKD) on top of the standard of care [blood glucose control, renin-angiotensin system blockade, smoking cessation and blood pressure (BP) control], even in patients with overt DKD. However, the indication of this drug class is still blood glucose lowering in type 2 diabetic patients with estimated glomerular filtration rate >45mL/min/1.73m(2). Based on the new evidence, several scientific societies have emphasized the preferential prescription of SGLT2i for patients at risk of heart failure or kidney disease, but still within the limits set by health authorities. A rapid positioning of both the European Medicines Agency and the US Food and Drug Administration will allow patients with overt DKD to benefit from SGLT2i. Clinical experience suggests that SGLT2i safety management may in part mirror renin-angiotensin blockade safety management in patients with overt DKD. This review focuses on the rationale for an indication of SGTL2i in DKD. We further propose clinical steps for maximizing the safety of SGLT2i in DKD patients on other antidiabetic, BP or diuretic medication.

Published
2020

29. Mortality reduction by post-dilution online-haemodiafiltration : A cause-specific analysis

Author

Nubé, Menso J., Peters, Sanne A E, Blankestijn, Peter J., Canaud, Bernard, Davenport, Andrew, Grooteman, Muriel P C, Asci, Gulay, Locatelli, Francesco, Maduell, Francisco, Morena, Marion, Ok, Ercan, Torres, Ferran, Bots, Michiel L., Moreso, Francesc, Pons, Mercedes, Ramos, Rosa, Mora-Macià, Josep, Carreras, Jordi, Soler, Jordi, Campistol, Josep M., Martinez-Castelao, Alberto, Insensé, B., Perez, C., Feliz, T., Barbetta, M., Soto, C., Mora, J., Juan, A., Ibrik, O., Foraster, A., Nin, J., Fernández, A., Arruche, M., Sánchez, C., Vidiella, J., Barbosa, F., Chiné, M., Hurtado, S., Llibre, J., Ruiz, A., Serra, M., Salvó, M., Poyuelo, T., Maduell, F., Carrera, M., Fontseré, N., Arias, M., Merín, A., Ribera, L., Galceran, J. M., Mòdol, J., Moliner, E., Ramirez, A., Aguilera, J., Alvarez, M., De La Torre, B., Molera, M., Casellas, J., Martín, G., Andres, E., Coll, E., Valles, M., Martínez, C., Castellote, E., Casals, J. M., Gabàs, J., Romero, M., Martinez-Castelao, A., Fulladosa, X., Ramirez-Arellano, M., Fulquet, M., Pelegrí, A., El Manouari, M., Ramos, N., Bartolomé, J., Sans, R., Fernández, E., Sarró, F., Compte, T., Marco, F., Mauri, R., Bronsoms, J., Arnaiz, J. A., Beleta, H., Pejenaute, A., Ríos, J., Lara, J., Ter Wee, P. M., Van Den Dorpel, M. A., Dorval, M., Lévesque, R., Koopman, M. G., Konings, C. J A M, Haanstra, W. P., Kooistra, M., Van Jaarsveld, B., Noordzij, T., Feith, G. W., Peltenburg, H. G., Van Buren, M., Offerman, J. J G, Hoogeveen, E. K., De Heer, F., Van De Ven, P. J., Kremer Hovinga, T. K., Bax, W. A., Groeneveld, J. O., Lavrijssen, A. T J, Schrander-Van Der Meer, A. M., Reichert, L. J M, Huussen, J., Rensma, P. L., Schrama, Y., Van Hamersvelt, H. W., Boer, W. H., Van Kuijk, W. H., Vervloet, M. G., Wauters, I. M P M J, Sekse, I., Toz, Huseyin, Ok, Ebru Sevinc, Kircelli, Fatih, Yilmaz, Mumtaz, Hur, Ender, Demirci, Meltem Sezis, Demirci, Cenk, Duman, Soner, Basci, Ali, Adam, Siddig Momin, Isik, Ismet Onder, Zengin, Murat, Suleymanlar, Gultekin, Yilmaz, Mehmet Emin, Ergin, Mehmet Ozkahya Pinar, Sagdic, Alfert, Kayali, Erkan, Boydak, Can, Colak, Taskin, Caliskan, Sihli, Kaplan, Hakan, Ulas, Hasibe, Kirbiyik, Sait, Berktas, Hakan, Dilbaz, Necati, Cristol, Jean Paul, Leray-Moragues, Hélène, Chenine, Leïla, Picot, Marie Christine, Jaussent, Audrey, Belloc, Claire, Lagarrigue, Mélodie, Chalabi, Lotfi, Debure, Alain, Ouziala, Messaoud, Lefevre, Jean Jacques, Thibaudin, Damien, Mohey, Hesham, Broyet, Christian, Afiani, Aida, Serveaux, Marie Odile, Patrier, Laure, Maurice, François, Rivory, Jean Pierre, Nicoud, Philippe, Durand, Claude, Normand, Michel, Seigneuric, Bruno, Magnant, Eric, Azzouz, Lynda, Islam, Mohamed Shariful, Vido, Sandor, Nzeyimana, Hilaire, Simonin, Danièle, Azymah, Yamina, Farah, Ibrahim, Coindre, Jean Philippe, Puyoo, Olivier, Chabannier, Marie Hélène, Ibos, Richard, Rouleau, Fabienne, Vela, Carlos, Joule, Josiane, Combarnous, François, Turc-Baron, Cécile, Ducret, Francis, Pointet, Philippe, Rey, Isabelle, Potier, Jacky, Bendini, Jean Christophe, Perrin, Franck, Kunz, Kristian, Lefrancois, Gaëlle, Colin, Angélique, Parahy, Sophie, Dancea, Irima, Coupel, Stéphanie, Testa, Angelo, Brunet, Philippe, Lebrun, Gaétan, Jaubert, Dominique, Delcroix, Catherine, Lavainne, Frédéric, Lefebvre, Anne, Guillodo, Marie Paule, Le Grignou, Dominique, Djema, Assia, Maaz, Mehadji, Chiron, Sylvie, Hoffmann, Maxime, Depraetre, Pascale, Haddj-Elmrabet, Atman, Joyeux, Véronique, Fleury, Dominique, Vrigneaud, Laurence, Lemaitre, Vincent, Aguilera, Didier, Guerraoui, Abdallah, Cremault, Alain, Laradi, Achour, Babinet, Francois, Nubé, Menso J., Peters, Sanne A E, Blankestijn, Peter J., Canaud, Bernard, Davenport, Andrew, Grooteman, Muriel P C, Asci, Gulay, Locatelli, Francesco, Maduell, Francisco, Morena, Marion, Ok, Ercan, Torres, Ferran, Bots, Michiel L., Moreso, Francesc, Pons, Mercedes, Ramos, Rosa, Mora-Macià, Josep, Carreras, Jordi, Soler, Jordi, Campistol, Josep M., Martinez-Castelao, Alberto, Insensé, B., Perez, C., Feliz, T., Barbetta, M., Soto, C., Mora, J., Juan, A., Ibrik, O., Foraster, A., Nin, J., Fernández, A., Arruche, M., Sánchez, C., Vidiella, J., Barbosa, F., Chiné, M., Hurtado, S., Llibre, J., Ruiz, A., Serra, M., Salvó, M., Poyuelo, T., Maduell, F., Carrera, M., Fontseré, N., Arias, M., Merín, A., Ribera, L., Galceran, J. M., Mòdol, J., Moliner, E., Ramirez, A., Aguilera, J., Alvarez, M., De La Torre, B., Molera, M., Casellas, J., Martín, G., Andres, E., Coll, E., Valles, M., Martínez, C., Castellote, E., Casals, J. M., Gabàs, J., Romero, M., Martinez-Castelao, A., Fulladosa, X., Ramirez-Arellano, M., Fulquet, M., Pelegrí, A., El Manouari, M., Ramos, N., Bartolomé, J., Sans, R., Fernández, E., Sarró, F., Compte, T., Marco, F., Mauri, R., Bronsoms, J., Arnaiz, J. A., Beleta, H., Pejenaute, A., Ríos, J., Lara, J., Ter Wee, P. M., Van Den Dorpel, M. A., Dorval, M., Lévesque, R., Koopman, M. G., Konings, C. J A M, Haanstra, W. P., Kooistra, M., Van Jaarsveld, B., Noordzij, T., Feith, G. W., Peltenburg, H. G., Van Buren, M., Offerman, J. J G, Hoogeveen, E. K., De Heer, F., Van De Ven, P. J., Kremer Hovinga, T. K., Bax, W. A., Groeneveld, J. O., Lavrijssen, A. T J, Schrander-Van Der Meer, A. M., Reichert, L. J M, Huussen, J., Rensma, P. L., Schrama, Y., Van Hamersvelt, H. W., Boer, W. H., Van Kuijk, W. H., Vervloet, M. G., Wauters, I. M P M J, Sekse, I., Toz, Huseyin, Ok, Ebru Sevinc, Kircelli, Fatih, Yilmaz, Mumtaz, Hur, Ender, Demirci, Meltem Sezis, Demirci, Cenk, Duman, Soner, Basci, Ali, Adam, Siddig Momin, Isik, Ismet Onder, Zengin, Murat, Suleymanlar, Gultekin, Yilmaz, Mehmet Emin, Ergin, Mehmet Ozkahya Pinar, Sagdic, Alfert, Kayali, Erkan, Boydak, Can, Colak, Taskin, Caliskan, Sihli, Kaplan, Hakan, Ulas, Hasibe, Kirbiyik, Sait, Berktas, Hakan, Dilbaz, Necati, Cristol, Jean Paul, Leray-Moragues, Hélène, Chenine, Leïla, Picot, Marie Christine, Jaussent, Audrey, Belloc, Claire, Lagarrigue, Mélodie, Chalabi, Lotfi, Debure, Alain, Ouziala, Messaoud, Lefevre, Jean Jacques, Thibaudin, Damien, Mohey, Hesham, Broyet, Christian, Afiani, Aida, Serveaux, Marie Odile, Patrier, Laure, Maurice, François, Rivory, Jean Pierre, Nicoud, Philippe, Durand, Claude, Normand, Michel, Seigneuric, Bruno, Magnant, Eric, Azzouz, Lynda, Islam, Mohamed Shariful, Vido, Sandor, Nzeyimana, Hilaire, Simonin, Danièle, Azymah, Yamina, Farah, Ibrahim, Coindre, Jean Philippe, Puyoo, Olivier, Chabannier, Marie Hélène, Ibos, Richard, Rouleau, Fabienne, Vela, Carlos, Joule, Josiane, Combarnous, François, Turc-Baron, Cécile, Ducret, Francis, Pointet, Philippe, Rey, Isabelle, Potier, Jacky, Bendini, Jean Christophe, Perrin, Franck, Kunz, Kristian, Lefrancois, Gaëlle, Colin, Angélique, Parahy, Sophie, Dancea, Irima, Coupel, Stéphanie, Testa, Angelo, Brunet, Philippe, Lebrun, Gaétan, Jaubert, Dominique, Delcroix, Catherine, Lavainne, Frédéric, Lefebvre, Anne, Guillodo, Marie Paule, Le Grignou, Dominique, Djema, Assia, Maaz, Mehadji, Chiron, Sylvie, Hoffmann, Maxime, Depraetre, Pascale, Haddj-Elmrabet, Atman, Joyeux, Véronique, Fleury, Dominique, Vrigneaud, Laurence, Lemaitre, Vincent, Aguilera, Didier, Guerraoui, Abdallah, Cremault, Alain, Laradi, Achour, and Babinet, Francois

Published
2017

30. Mortality reduction by post-dilution online-haemodiafiltration: A cause-specific analysis

Author

Cardiovasculaire Epi Team 5, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Circulatory Health, MS Nefrologie, MS CGO, MS Medische Oncologie, Cancer, Projectafdeling VCI, Secretariaat en overig CTC, AIOS Anesthesiologie, Nubé, Menso J., Peters, Sanne A E, Blankestijn, Peter J., Canaud, Bernard, Davenport, Andrew, Grooteman, Muriel P C, Asci, Gulay, Locatelli, Francesco, Maduell, Francisco, Morena, Marion, Ok, Ercan, Torres, Ferran, Bots, Michiel L., Moreso, Francesc, Pons, Mercedes, Ramos, Rosa, Mora-Macià, Josep, Carreras, Jordi, Soler, Jordi, Campistol, Josep M., Martinez-Castelao, Alberto, Insensé, B., Perez, C., Feliz, T., Barbetta, M., Soto, C., Mora, J., Juan, A., Ibrik, O., Foraster, A., Nin, J., Fernández, A., Arruche, M., Sánchez, C., Vidiella, J., Barbosa, F., Chiné, M., Hurtado, S., Llibre, J., Ruiz, A., Serra, M., Salvó, M., Poyuelo, T., Maduell, F., Carrera, M., Fontseré, N., Arias, M., Merín, A., Ribera, L., Galceran, J. M., Mòdol, J., Moliner, E., Ramirez, A., Aguilera, J., Alvarez, M., De La Torre, B., Molera, M., Casellas, J., Martín, G., Andres, E., Coll, E., Valles, M., Martínez, C., Castellote, E., Casals, J. M., Gabàs, J., Romero, M., Martinez-Castelao, A., Fulladosa, X., Ramirez-Arellano, M., Fulquet, M., Pelegrí, A., El Manouari, M., Ramos, N., Bartolomé, J., Sans, R., Fernández, E., Sarró, F., Compte, T., Marco, F., Mauri, R., Bronsoms, J., Arnaiz, J. A., Beleta, H., Pejenaute, A., Ríos, J., Lara, J., Ter Wee, P. M., Van Den Dorpel, M. A., Dorval, M., Lévesque, R., Koopman, M. G., Konings, C. J A M, Haanstra, W. P., Kooistra, M., Van Jaarsveld, B., Noordzij, T., Feith, G. W., Peltenburg, H. G., Van Buren, M., Offerman, J. J G, Hoogeveen, E. K., De Heer, F., Van De Ven, P. J., Kremer Hovinga, T. K., Bax, W. A., Groeneveld, J. O., Lavrijssen, A. T J, Schrander-Van Der Meer, A. M., Reichert, L. J M, Huussen, J., Rensma, P. L., Schrama, Y., Van Hamersvelt, H. W., Boer, W. H., Van Kuijk, W. H., Vervloet, M. G., Wauters, I. M P M J, Sekse, I., Toz, Huseyin, Ok, Ebru Sevinc, Kircelli, Fatih, Yilmaz, Mumtaz, Hur, Ender, Demirci, Meltem Sezis, Demirci, Cenk, Duman, Soner, Basci, Ali, Adam, Siddig Momin, Isik, Ismet Onder, Zengin, Murat, Suleymanlar, Gultekin, Yilmaz, Mehmet Emin, Ergin, Mehmet Ozkahya Pinar, Sagdic, Alfert, Kayali, Erkan, Boydak, Can, Colak, Taskin, Caliskan, Sihli, Kaplan, Hakan, Ulas, Hasibe, Kirbiyik, Sait, Berktas, Hakan, Dilbaz, Necati, Cristol, Jean Paul, Leray-Moragues, Hélène, Chenine, Leïla, Picot, Marie Christine, Jaussent, Audrey, Belloc, Claire, Lagarrigue, Mélodie, Chalabi, Lotfi, Debure, Alain, Ouziala, Messaoud, Lefevre, Jean Jacques, Thibaudin, Damien, Mohey, Hesham, Broyet, Christian, Afiani, Aida, Serveaux, Marie Odile, Patrier, Laure, Maurice, François, Rivory, Jean Pierre, Nicoud, Philippe, Durand, Claude, Normand, Michel, Seigneuric, Bruno, Magnant, Eric, Azzouz, Lynda, Islam, Mohamed Shariful, Vido, Sandor, Nzeyimana, Hilaire, Simonin, Danièle, Azymah, Yamina, Farah, Ibrahim, Coindre, Jean Philippe, Puyoo, Olivier, Chabannier, Marie Hélène, Ibos, Richard, Rouleau, Fabienne, Vela, Carlos, Joule, Josiane, Combarnous, François, Turc-Baron, Cécile, Ducret, Francis, Pointet, Philippe, Rey, Isabelle, Potier, Jacky, Bendini, Jean Christophe, Perrin, Franck, Kunz, Kristian, Lefrancois, Gaëlle, Colin, Angélique, Parahy, Sophie, Dancea, Irima, Coupel, Stéphanie, Testa, Angelo, Brunet, Philippe, Lebrun, Gaétan, Jaubert, Dominique, Delcroix, Catherine, Lavainne, Frédéric, Lefebvre, Anne, Guillodo, Marie Paule, Le Grignou, Dominique, Djema, Assia, Maaz, Mehadji, Chiron, Sylvie, Hoffmann, Maxime, Depraetre, Pascale, Haddj-Elmrabet, Atman, Joyeux, Véronique, Fleury, Dominique, Vrigneaud, Laurence, Lemaitre, Vincent, Aguilera, Didier, Guerraoui, Abdallah, Cremault, Alain, Laradi, Achour, Babinet, Francois, Cardiovasculaire Epi Team 5, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Circulatory Health, MS Nefrologie, MS CGO, MS Medische Oncologie, Cancer, Projectafdeling VCI, Secretariaat en overig CTC, AIOS Anesthesiologie, Nubé, Menso J., Peters, Sanne A E, Blankestijn, Peter J., Canaud, Bernard, Davenport, Andrew, Grooteman, Muriel P C, Asci, Gulay, Locatelli, Francesco, Maduell, Francisco, Morena, Marion, Ok, Ercan, Torres, Ferran, Bots, Michiel L., Moreso, Francesc, Pons, Mercedes, Ramos, Rosa, Mora-Macià, Josep, Carreras, Jordi, Soler, Jordi, Campistol, Josep M., Martinez-Castelao, Alberto, Insensé, B., Perez, C., Feliz, T., Barbetta, M., Soto, C., Mora, J., Juan, A., Ibrik, O., Foraster, A., Nin, J., Fernández, A., Arruche, M., Sánchez, C., Vidiella, J., Barbosa, F., Chiné, M., Hurtado, S., Llibre, J., Ruiz, A., Serra, M., Salvó, M., Poyuelo, T., Maduell, F., Carrera, M., Fontseré, N., Arias, M., Merín, A., Ribera, L., Galceran, J. M., Mòdol, J., Moliner, E., Ramirez, A., Aguilera, J., Alvarez, M., De La Torre, B., Molera, M., Casellas, J., Martín, G., Andres, E., Coll, E., Valles, M., Martínez, C., Castellote, E., Casals, J. M., Gabàs, J., Romero, M., Martinez-Castelao, A., Fulladosa, X., Ramirez-Arellano, M., Fulquet, M., Pelegrí, A., El Manouari, M., Ramos, N., Bartolomé, J., Sans, R., Fernández, E., Sarró, F., Compte, T., Marco, F., Mauri, R., Bronsoms, J., Arnaiz, J. A., Beleta, H., Pejenaute, A., Ríos, J., Lara, J., Ter Wee, P. M., Van Den Dorpel, M. A., Dorval, M., Lévesque, R., Koopman, M. G., Konings, C. J A M, Haanstra, W. P., Kooistra, M., Van Jaarsveld, B., Noordzij, T., Feith, G. W., Peltenburg, H. G., Van Buren, M., Offerman, J. J G, Hoogeveen, E. K., De Heer, F., Van De Ven, P. J., Kremer Hovinga, T. K., Bax, W. A., Groeneveld, J. O., Lavrijssen, A. T J, Schrander-Van Der Meer, A. M., Reichert, L. J M, Huussen, J., Rensma, P. L., Schrama, Y., Van Hamersvelt, H. W., Boer, W. H., Van Kuijk, W. H., Vervloet, M. G., Wauters, I. M P M J, Sekse, I., Toz, Huseyin, Ok, Ebru Sevinc, Kircelli, Fatih, Yilmaz, Mumtaz, Hur, Ender, Demirci, Meltem Sezis, Demirci, Cenk, Duman, Soner, Basci, Ali, Adam, Siddig Momin, Isik, Ismet Onder, Zengin, Murat, Suleymanlar, Gultekin, Yilmaz, Mehmet Emin, Ergin, Mehmet Ozkahya Pinar, Sagdic, Alfert, Kayali, Erkan, Boydak, Can, Colak, Taskin, Caliskan, Sihli, Kaplan, Hakan, Ulas, Hasibe, Kirbiyik, Sait, Berktas, Hakan, Dilbaz, Necati, Cristol, Jean Paul, Leray-Moragues, Hélène, Chenine, Leïla, Picot, Marie Christine, Jaussent, Audrey, Belloc, Claire, Lagarrigue, Mélodie, Chalabi, Lotfi, Debure, Alain, Ouziala, Messaoud, Lefevre, Jean Jacques, Thibaudin, Damien, Mohey, Hesham, Broyet, Christian, Afiani, Aida, Serveaux, Marie Odile, Patrier, Laure, Maurice, François, Rivory, Jean Pierre, Nicoud, Philippe, Durand, Claude, Normand, Michel, Seigneuric, Bruno, Magnant, Eric, Azzouz, Lynda, Islam, Mohamed Shariful, Vido, Sandor, Nzeyimana, Hilaire, Simonin, Danièle, Azymah, Yamina, Farah, Ibrahim, Coindre, Jean Philippe, Puyoo, Olivier, Chabannier, Marie Hélène, Ibos, Richard, Rouleau, Fabienne, Vela, Carlos, Joule, Josiane, Combarnous, François, Turc-Baron, Cécile, Ducret, Francis, Pointet, Philippe, Rey, Isabelle, Potier, Jacky, Bendini, Jean Christophe, Perrin, Franck, Kunz, Kristian, Lefrancois, Gaëlle, Colin, Angélique, Parahy, Sophie, Dancea, Irima, Coupel, Stéphanie, Testa, Angelo, Brunet, Philippe, Lebrun, Gaétan, Jaubert, Dominique, Delcroix, Catherine, Lavainne, Frédéric, Lefebvre, Anne, Guillodo, Marie Paule, Le Grignou, Dominique, Djema, Assia, Maaz, Mehadji, Chiron, Sylvie, Hoffmann, Maxime, Depraetre, Pascale, Haddj-Elmrabet, Atman, Joyeux, Véronique, Fleury, Dominique, Vrigneaud, Laurence, Lemaitre, Vincent, Aguilera, Didier, Guerraoui, Abdallah, Cremault, Alain, Laradi, Achour, and Babinet, Francois

Published
2017

34. Association of Candidate Gene Polymorphisms With Chronic Kidney Disease: Results of a Case-Control Analysis in the Nefrona Cohort

Author

Valls, Joan, Perez-Guallar, Carles, Cambray, Serafi, Bozic, Milica, Bermudez-Lopez, Marcelino, Fernandez, Elvira, Betriu, Angels, Rodriguez, Isabel, Valdivielso, Jose M., Aladren Regidor, Ma Jose, Almirall, Jaume, Ponz, Esther, Arteaga Coloma, Jesus, Bajo Rubio, Ma Auxiliadora, Diaz, Raquel Raquel, Belart Rodriguez, Montserrat, Gascon, Antonio, Bover Sanjuan, Jordi, Bronsoms Artero, Josep, Cabezuelo Romero, Juan B., Muray Cases, Salome, Calvino Varela, Jesus, Caro Acevedo, Pilar, Carreras Bassa, Jordi, Cases Amenos, Aleix, Masso Jimenez, Elisabet, Moreno Lopez, Rosario, Cigarran Guldris, Secundino, Lopez Prieto, Saray, Comas Mongay, Lourdes, Comerma, Isabel, Compte Jove, Ma Teresa, Cuberes Izquierdo, Marta, de Alvaro, Fernando, Hevia Ojanguren, Covadonga, de Arriba de la Fuente, Gabriel, del Pino y Pino, Ma Dolores, Diaz-Tejeiro Izquierdo, Rafael, Ahijado Hormigos, Francisco, Dotori, Marta, Duarte, Veronica, Estupinan Torres, Sara, Fernandez Reyes, Ma Jose, Fernandez Rodriguez, Ma Loreto, Fernandez, Guillermina, Galan Serrano, Antonio, Garcia Canton, Cesar, Garcia Herrera, Antonio L., Garcia Mena, Mercedes, Gil Sacaluga, Luis, Aguilar, Maria, Gorriz, Jose Luis, Huarte Loza, Emma, Lerma, Jose Luis, Liebana Canada, Antonio, Marin Alvarez, Jesus Pedro, Martin Alemany, Nadia, Martin Garcia, Jesus, Martinez Castelao, Alberto, Martinez Villaescusa, Maria, Martinez, Isabel, Moina Eguren, Inigo, Moreno Los Huertos, Silvia, Mouzo Mirco, Ricardo, Munar Vila, Antonia, Munoz Diaz, Ana Beatriz, Navarro Gonzalez, Juan F., Nieto, Javier, Carreno, Agustin, Novoa Fernandez, Enrique, Ortiz, Alberto, Fernandez, Beatriz, Paraiso, Vicente, Perez Fontan, Miguel, Peris Domingo, Ana, Pinera Haces, Celestino, Prados Garrido, Ma Dolores, Prieto Velasco, Mario, Puig Mari, Carmina, Rivera Gorrin, Maite, Rubio, Esther, Ruiz, Pilar, Salgueira Lazo, Mercedes, Martinez Puerto, Ana Isabel, Sanchez Tomero, Jose Antonio, Sanchez, Jose Emilio, Sans Lorman, Ramon, Saracho, Ramon, Sarrias, Maria, Seron, Daniel, Soler, Maria Jose, Barrios, Clara, Sousa, Fernando, Toran, Daniel, Tornero Molina, Fernando, Uson Carrasco, Jose Javier, Valera Cortes, Ildefonso, Vilaprinyo del Perugia, Ma Merce, Virto Ruiz, Rafael C., Santos Altozano, Carlos, Artigao Rodenas, Miguel, Gil Gil, Ines, Adan Gil, Francisco, Garcia Criado, Emilio, Dura Belinchon, Rafael, Fernandez Toro, Jose Ma, and Divison Garrote, Juan Antonio

Abstract

Chronic kidney disease (CKD) is a major risk factor for end-stage renal disease, cardiovascular disease and premature death. Despite classical clinical risk factors for CKD and some genetic risk factors have been identified, the residual risk observed in prediction models is still high. Therefore, new risk factors need to be identified in order to better predict the risk of CKD in the population. Here, we analyzed the genetic association of 79 SNPs of proteins associated with mineral metabolism disturbances with CKD in a cohort that includes 2, 445 CKD cases and 559 controls. Genotyping was performed with matrix assisted laser desorption ionizationtime of flight mass spectrometry. We used logistic regression models considering different genetic inheritance models to assess the association of the SNPs with the prevalence of CKD, adjusting for known risk factors. Eight SNPs (rs1126616, rs35068180, rs2238135, rs1800247, rs385564, rs4236, rs2248359, and rs1564858) were associated with CKD even after adjusting by sex, age and race. A model containing five of these SNPs (rs1126616, rs35068180, rs1800247, rs4236, and rs2248359), diabetes and hypertension showed better performance than models considering only clinical risk factors, significantly increasing the area under the curve of the model without polymorphisms. Furthermore, one of the SNPs (the rs2248359) showed an interaction with hypertension, being the risk genotype affecting only hypertensive patients. We conclude that 5 SNPs related to proteins implicated in mineral metabolism disturbances (Osteopontin, osteocalcin, matrix gla protein, matrix metalloprotease 3 and 24 hydroxylase) are associated to an increased risk of suffering CKD.

Published
2019

36. Canagliflozin and Renal Events in Diabetes with Established Nephropathy Clinical Evaluation and Study of Diabetic Nephropathy with Atrasentan : what was learned about the treatment of diabetic kidney disease with canagliflozin and atrasentan?

Author

Fernandez-Fernandez, Beatriz, Fernandez-Prado, Raul, Górriz, Jose Luis, Martinez-Castelao, Alberto, Navarro-González, Juan F., Porrini, Esteban, Soler, María José, Ortiz, Alberto, Universitat Autònoma de Barcelona, and Hospital Universitary Vall d'Hebron

Subjects
Sodium-glucose cotransporter-2 (SGLT2) inhibitor, Chronic kidney disease, Atrasentan, Albuminuria, Canagliflozin, Diabetic kidney disease, Endothelin
Abstract

In April 2019, two major Phase 3 randomized clinical trials were published that assessed primary renal outcomes in diabetic kidney disease (DKD) in type 2 diabetes mellitus (T2DM). The Canagliflozin and Renal Events in Diabetes with Established Nephropathy Clinical Evaluation (CREDENCE) tested an already available antidiabetic drug, canagliflozin, and the Study of Diabetic Nephropathy with Atrasentan (SONAR) tested a novel molecule, the endothelin-1 receptor blocker atrasentan, both on top of renin-angiotensin system blockade. Both trials demonstrated significant nephroprotection in patients with overt DKD (albuminuria >300 mg/g urinary creatinine) for combined primary endpoints of end-stage kidney disease (ESKD), doubling of serum creatinine or death from renal or cardiovascular causes in CREDENCE {hazard ratio [HR] 0.70 [95% confidence interval (CI) 0.59-0.82]} and ESKD and doubling of serum creatinine in SONAR [HR 0.65 (95% CI 0.49-0.88)]. Canagliflozin also decreased the secondary renal endpoint ESKD, doubling of serum creatinine or renal death [HR 0.66 (95% CI 0.53-0.81)], which was similar in nature and impact to the primary endpoint in SONAR. In addition, canagliflozin decreased a secondary endpoint of cardiovascular death or hospitalization for heart failure [HR 0.69 (95% CI 0.57-0.83)], whereas atrasentan had no significant impact on a secondary cardiovascular composite endpoint or on hospital admissions for heart failure and, despite restrictive exclusion criteria, there was a non-significant trend towards more frequent episodes of heart failure. Based on these results, canagliflozin will likely be approved for the indication of treating DKD in T2DM and the estimated glomerular filtration rate threshold for prescribing it will be lifted, whereas the future and place of atrasentan in the treatment of DKD remain unclear.

Published
2019

40. Different rates of progression and mortality in patients with chronic kidney disease at outpatient nephrology clinics across Europe

Author

Stein Hallan, Aminu K. Bello, Johan Ärnlöv, Katharina Brück, Daniela Leonardis, Kyriakos Ioannou, Wim Van Biesen, Christoph Wanner, Alberto Martinez Castelao, Kitty J Jager, Ben Caplin, José Luis Górriz, Vianda S. Stel, Hermann Brenner, Philip A. Kalra, Henry Völzke, Francis Verbeke, Pietro Manuel Ferraro, Dino Gibertoni, Dietrich Rothenbacher, Georg Heinze, Carmine Zoccali, Roberto Minutolo, Luca De Nicola, Brück, Katharina, Jager, Kitty J., Zoccali, Carmine, Bello, Aminu K., Minutolo, Roberto, Ioannou, Kyriako, Verbeke, Franci, Völzke, Henry, Arnlöv, Johan, Leonardis, Daniela, Ferraro, Pietro Manuel, Brenner, Hermann, Caplin, Ben, Kalra, Philip A., Wanner, Christoph, Castelao, Alberto Martinez, Gorriz, Jose Lui, Hallan, Stein, Rothenbacher, Dietrich, Gibertoni, Dino, De Nicola, Luca, Heinze, Georg, Van Biesen, Wim, Stel, Vianda S., Radiotherapy, Radiology and Nuclear Medicine, ACS - Pulmonary hypertension & thrombosis, APH - Aging & Later Life, Medical Informatics, APH - Quality of Care, and APH - Global Health

Subjects
Adult, Male, Nephrology, medicine.medical_specialty, obesity, Time Factors, Adolescent, medicine.medical_treatment, Population, 030232 urology & nephrology, 030204 cardiovascular system & hematology, Kidney, Ambulatory Care Facilities, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, cardiovascular disease, Internal medicine, ACE inhibitor, Epidemiology, medicine, Humans, Settore MED/14 - NEFROLOGIA, Prospective Studies, Renal replacement therapy, Renal Insufficiency, Chronic, education, Aged, Aged, 80 and over, education.field_of_study, business.industry, Incidence (epidemiology), Hazard ratio, Middle Aged, medicine.disease, Europe, diabete, Cohort, Disease Progression, ACE inhibitors, chronic kidney disease, diabetes, Female, business, Glomerular Filtration Rate, Kidney disease
Abstract

The incidence of renal replacement therapy varies across countries. However, little is known about the epidemiology of chronic kidney disease (CKD) outcomes. Here we describe progression and mortality risk of patients with CKD but not on renal replacement therapy at outpatient nephrology clinics across Europe using individual data from nine CKD cohorts participating in the European CKD Burden Consortium. A joint model assessed the mean change in estimated glomerular filtration rate (eGFR) and mortality risk simultaneously, thereby accounting for mortality risk when estimating eGFR decline and vice versa, while also correcting for the measurement error in eGFR. Results were adjusted for important risk factors (baseline eGFR, age, sex, albuminuria, primary renal disease, diabetes, hypertension, obesity and smoking) in 27,771 patients from five countries. The adjusted mean annual eGFR decline varied from 0.77 (95% confidence interval 0.45, 1.08) ml/min/1.73m2 in the Belgium cohort to 2.43 (2.11, 2.75) ml/min/1.73m2 in the Spanish cohort. As compared to the Italian PIRP cohort, the adjusted mortality hazard ratio varied from 0.22 (0.11, 0.43) in the London LACKABO cohort to 1.30 (1.13, 1.49) in the English CRISIS cohort. These results suggest that the eGFR decline showed minor variation but mortality showed the most variation. Thus, different health care organization systems are potentially associated with differences in outcome of patients with CKD within Europe. These results can be used by policy makers to plan resources on a regional, national and European level.

Published
2018

49. Anaemia in CKD 1-5

Author

M. Hirata, Y. Tashiro, K. Aizawa, K. Endo, K. Serizawa, K. Yogo, A. Cases, J. Portoles, J. Calls, A. Martinez-Castelao, M. A. Munar, A. Segarra, E. Samouilidou, K. Pantelias, D. Petras, T. Mpakirtzi, C. Pipili, G. Chatzivasileiou, K. Vasiliou, E. Denda, E. Grapsa, H. Tzanatos, S. Shoji, M. Inaba, N. Tomosugi, S. Okuno, M. Ichii, T. Yamakawa, S. Kurihara, L. Barsan, A. Stanciu, S. Stancu, C. Capusa, L. Bratescu, G. Mircescu, K.-L. Kuo, S.-C. Hung, T.-S. Lee, D.-C. Tarng, I. Nistor, A. Covic, D. Goldsmith, P. Garrido, J. Fernandes, S. Ribeiro, H. Vala, B. Parada, R. Alves, L. Belo, E. Costa, A. Santos-Silva, F. Reis, K. Abdulnabi, A. Ullah, A. Abdulateef, M. Howse, A. Khalil, B. Fouqueray, M. Hoffmann, J. Addison, N. Manamley, D. Stamopoulos, N. Mpakirtzi, N. Afentakis, K.- H. Yu, J. Chou, S. Klaus, M. Schaddelee, M. Kashiwa, A. Takada, T. Neff, J. Galle, K. Claes, S. Di Giulio, A. Guerin, H. Herlitz, I. Kiss, G. Wirnsberger, M. Froissart, C. Winearls, A. Martinez Castelao, A. Cases Amenos, A. Torre Carballada, F. J. Torralba Iranzo, J. M. Bronsoms Artero, D. Toran Monserrat, M. Valles Prats, J. L. Merino, B. Espejo, B. Bueno, Y. Amezquita, V. Paraiso, Z. Kiss, L. Kerkovits, C. Ambrus, I. Kulcsar, J. Szegedi, A. Benke, B. Borbas, S. Ferenczi, M. Hengsperger, S. Kazup, L. Nagy, J. Nemeth, A. Rozinka, T. Szabo, T. Szelestei, E. Toth, G. Varga, G. Wagner, G. Zakar, L. Gergely, K. Exarchou, N. Tanahill, A. Anthoney, S. Ahmed, R. Oprican, M. Lipan, B. Chirculescu, S. Roger, R. Malecki, M. Farouk, F. Dellanna, M. Thomas, M. Touam, F. Chantrel, M. Bouiller, J.-M. Hurot, T. Raphael, A. Testa, S. Veillon, B. Vendrely, Z. Masoumi, P. Ahmadpoor, S. M. H. Ghaderian, M. Nafar, S. Samavat, F. Samadian, F. Poorrezagholi, M. Shahidi, E. Riccio, B. Visciano, I. Capuano, A. Memoli, G. Mozzillo, B. Memoli, and A. Pisani

Subjects
Transplantation, medicine.medical_specialty, Nephrology, business.industry, Internal medicine, Medicine, business
Published
2013

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