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1. Did somebody say 'Gest-IT'? A pilot exploration of multimodal data management

Author

Pannitto, Ludovica, Albanesi, Lorenzo, Marion, Laura, Martines, Federica Maria, Caruso, Carmelo, Bianchini, Claudia S., Masini, Francesca, and Mauri, Caterina

Subjects
Computer Science - Computation and Language
Abstract

The paper presents a pilot exploration of the construction, management and analysis of a multimodal corpus. Through a three-layer annotation that provides orthographic, prosodic, and gestural transcriptions, the Gest-IT resource allows to investigate the variation of gesture-making patterns in conversations between sighted people and people with visual impairment. After discussing the transcription methods and technical procedures employed in our study, we propose a unified CoNLL-U corpus and indicate our future steps

Published
2024

2. Triple gauge coupling analysis using boosted $W$'s and $Z$'s

Author

Éboli, O. J. P., Ghosh, Tathagata, Martines, Matheus, and Shil, Sujay

Subjects
High Energy Physics - Phenomenology, High Energy Physics - Experiment
Abstract

We analyze the Large Hadron Collider potential to study triple couplings of the electroweak gauge bosons using their boosted hadronic decays. Deviations from Standard Model predictions spoil cancelations present in the Standard Model leading to the growth of the electroweak diboson production cross section at high center-of-mass energies. In this kinematical limit, $W$'s and $Z$'s are highly boosted, and consequently, their hadronic decays give rise to fat jets. Here, we show that the study of boosted hadronically decaying $W$ and $Z$ leads to limits on triple gauge couplings that are comparable to the ones originating from the leptonic decay channels., Comment: 9 pages, 2 figures

Published
2024

6. Global 30-Day Morbidity and Mortality of Primary Bariatric Surgery Combined with Another Procedure: The BLEND Study

Author

Martinino, Alessandro, Nanayakkara, Kushan D. L., Madhok, Brij, Wong, Geoffrey Yuet Mun, Abouelazayem, Mohamed, Pereira, Juan Pablo Scarano, Wazir, Ishaan, Balasubaramaniam, Vignesh, Said, Amira, Marques, Cláudia, Abdelbaeth, Amr, Al-Shami, Khayry, Albashari, Muna, Alkaseek, Akram, Almayouf, Mohammad Abdullah, Aloulou, Mohammad, Alqahtan, Awadh Robaan, Askari, Alan, Attia, Meena Faiez Assad, Awad, Ahmed K., Aykota, Muhammed Rasid, Bacalbasa, Nicolae, Barrera-Rodriguez, Francisco J., Benavoli, Domenico, Billa, Srikar, Borrelli, Vincenzo, Çalıkoğlu, İsmail, Campanelli, Michela, Carbajo, Miguel A., Chowdhury, Sharfuddin, Cristin, Luca, Dapri, Giovanni, Dong, Zhiyong, Elfawal, Mohamad Hayssam, Elgazar, Amr, Elhadi, Muhammed, Gentileschi, Paolo, Graham, Yitka, Haj, Bassel, Johnson, Joseph Andrew, Kalmoush, Abd-Elfattah Morsi, Kamal, Ayman, Kamocka, Anna, Khamees, Almu’atasim, Lisi, Giorgio, Hernandez, Edgard Efren Lozada, Marinari, Giuseppe M., Martines, Gennaro, Meric, Serhat, Mier, Fernando, Ali, Ahmed Mohamed, Mohammed, Diyaaldeen, Mohamed, Karim Mostafa, Mulita, Francesk, Musella, Mario, O’Malley, William Edward, Olmi, Stefano, Omarov, Taryel, Osama, Omnya, Perera, HMinali R., Piscitelli, Giovanni, Poghosyan, Tigran, Ramírez, David, Rezvani, Masoud, Ribeiro, Rui, Sabbota, Aaron, Sakran, Nasser, Sawaftah, Khaled Ahmad, Schiavone, Kaci, Şen, Ozan, Sotiropoulou, Maria, Tartaglia, Nicola, Tokocin, Merve, Trotta, Manuela, Türkçapar, Ahmet Gökhan, Uccelli, Matteo, Vargas, Cesar, Verras, Georgios -Ioannis, Wang, Cunchuan, Wei, Zhuoqi, Yang, Wah, Zerrweck, Carlos, Owen, Eloise, Gkoutos, Georgios V., Cardoso, Victor Roth, Singhal, Rishi, and Mahawar, Kamal

Published
2024
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9. Relapsed Mpox Keratitis, St. Louis, Missouri, USA

Author

Pi, Cinthia, Adah, Osasu, Cholli, PreetamA., Martines, Roosecelis, Abate, Getahun, Hainaut, Lori, Seipel, Erich, Isbell, T. Scott, Frankel, Roddy, and Poowanawittayakom, Nongnooch

Subjects
Human monkeypox -- Complications and side effects, Diseases -- Relapse, Keratitis -- Diagnosis -- Risk factors -- Causes of, Health, Diagnosis, Complications and side effects, Risk factors, Causes of
Abstract

Ocular mpox, caused by monkeypox virus (MPXV), can threaten eyesight and requires prompt ophthalmologic consultation. Understanding of the disease course, treatments, and treatment durations is limited. We describe a case [...]

Published
2024
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12. NFKBIE mutations are selected by the tumor microenvironment and contribute to immune escape in chronic lymphocytic leukemia

Author

Bonato, Alice, Chakraborty, Supriya, Bomben, Riccardo, Canarutto, Giulia, Felician, Giulia, Martines, Claudio, Zucchetto, Antonella, Pozzo, Federico, Vujovikj, Marija, Polesel, Jerry, Chiarenza, Annalisa, Del Principe, Maria Ilaria, Del Poeta, Giovanni, D’Arena, Giovanni, Marasca, Roberto, Tafuri, Agostino, Laurenti, Luca, Piazza, Silvano, Dimovski, Aleksandar J., Gattei, Valter, and Efremov, Dimitar G.

Published
2024
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13. Bounds on Quartic Gauge Couplings in HEFT from Electroweak Gauge Boson Pair Production at the LHC

Author

Eboli, O. J. P., Gonzalez-Garcia, M. C., and Martines, Matheus

Subjects
High Energy Physics - Phenomenology
Abstract

Precision measurements of anomalous quartic couplings of electroweak gauge bosons allow us to search for deviations of the Standard Model predictions and signals of new physics. Here, we obtain the constraints on anomalous quartic gauge couplings using the presently available data on the production of gauge-boson pairs via vector boson fusion. We work in the Higgs effective theory framework and obtain the present bounds on the operator's Wilson coefficients. Anomalous quartic gauge boson couplings lead to rapidly growing cross sections and we discuss the impact of a unitarization procedure on the attainable limits.

Published
2023

18. Goodbye Hartmann trial: a prospective, international, multicenter, observational study on the current use of a surgical procedure developed a century ago

Author

Perrone, Gennaro, Giuffrida, Mario, Abu-Zidan, Fikri, Kruger, Vitor F., Livrini, Marco, Petracca, Gabriele Luciano, Rossi, Giorgio, Tarasconi, Antonio, Tian, Brian W. C. A., Bonati, Elena, Mentz, Ricardo, Mazzini, Federico N., Campana, Juan P., Gasser, Elisabeth, Kafka-Ritsch, Reinhold, Felsenreich, Daniel M., Dawoud, Christopher, Riss, Stefan, Gomes, Carlos Augusto, Gomes, Felipe Couto, Gonzaga, Ricardo Alessandro Teixeira, Canton, Cassio Alfred Brattig, Pereira, Bruno Monteiro, Fraga, Gustavo P., Zem, Leticia Gonçalves, Cordeiro-Fonseca, Vinicius, de Mesquita Tauil, Renato, Atanasov, Boyko, Belev, Nikolay, Kovachev, Nikola, Meléndez, L. Juan José, Dimova, Ana, Dimov, Stefan, Zelić, Zdravko, Augustin, Goran, Bogdanić, Branko, Morić, Trpimir, Chouillard, Elie, Bajul, Melinda, De Simone, Belinda, Panis, Yves, Esposito, Francesco, Notarnicola, Margherita, Lauka, Lelde, Fabbri, Anna, Hentati, Hassen, Fnaiech, Iskander, Aurélien, Venara, Bougard, Marie, Roulet, Maxime, Demetrashvili, Zaza, Pipia, Irakli, Merabishvili, Giorgi, Bouliaris, Konstantinos, Koukoulis, Georgios, Doudakmanis, Christos, Xenaki, Sofia, Chrysos, Emmanuel, Kokkinakis, Stamatios, Vassiliu, Panteleimon, Michalopoulos, Nikolaos, Margaris, Ioannis, Kechagias, Aristotelis, Avgerinos, Konstantinos, Katunin, Jevgeni, Lostoridis, Eftychios, Nagorni, Eleni-Aikaterini, Pujante, Antonio, Mulita, Francesk, Maroulis, Ioannis, Vailas, Michail, Marinis, Athanasios, Siannis, Ioannis, Bourbouteli, Eirini, Manatakis, Dimitrios K., Tasis, Nikolaos, Acheimastos, Vasileios, Maria, Sotiropoulou, Stylianos, Kapiris, Kuzeridis, Harilaos, Korkolis, Dimitrios, Fradelos, Evangelos, Kavalieratos, George, Petropoulou, Thalia, Polydorou, Andreas, Papacostantinou, Ioannis, Triantafyllou, Tania, Kimpizi, Despina, Theodorou, Dimitrios, Toutouzas, Konstantinos, Chamzin, Alexandros, Frountzas, Maximos, Schizas, Dimitrios, Karavokyros, Ioannis, Syllaios, Athanasios, Charalabopoulos, Alexandros, Boura, Maria, Baili, Efstratia, Ioannidis, Orestis, Loutzidou, Lydia, Anestiadou, Elissavet, Tsouknidas, Ioannis, Petrakis, Georgios, Polenta, Eleni, Bains, Lovenish, Gupta, Rahul, Singh, Sudhir K., Khanduri, Archana, Bala, Miklosh, Kedar, Asaf, Pisano, Marcello, Podda, Mauro, Pisanu, Adolfo, Martines, Gennaro, Trigiante, Giuseppe, Lantone, Giuliano, Agrusa, Antonino, Di Buono, Giuseppe, Buscemi, Salvatore, Veroux, Massimiliano, Gioco, Rossella, Veroux, Gastone, Oragano, Luigi, Zonta, Sandro, Lovisetto, Federico, Feo, Carlo V., Pesce, Antonio, Fabbri, Nicolò, Lantone, Giulio, Marino, Fabio, Perrone, Fabrizio, Vincenti, Leonardo, Papagni, Vincenzo, Picciariello, Arcangelo, Rossi, Stefano, Picardi, Biagio, Del Monte, Simone Rossi, Visconti, Diego, Osella, Giulia, Petruzzelli, Luca, Pignata, Giusto, Andreuccetti, Jacopo, D’Alessio, Rossella, Buonfantino, Massimo, Guaitoli, Eleonora, Spinelli, Stefano, Sampietro, Gianluca Matteo, Corbellini, Carlo, Lorusso, Leonardo, Frontali, Alice, Pezzoli, Isabella, Bonomi, Alessandro, Chierici, Andrea, Cotsoglou, Christian, Manca, Giuseppe, Delvecchio, Antonella, Musa, Nicola, Casati, Massimiliano, Letizia, Laface, Abate, Emmanuele, Ercolani, Giorgio, D’Acapito, Fabrizio, Solaini, Leonardo, Guercioni, Gianluca, Cicconi, Simone, Sasia, Diego, Borghi, Felice, Giraudo, Giorgio, Sena, Giuseppe, Castaldo, Pasquale, Cardamone, Eugenia, Portale, Giuseppe, Zuin, Matteo, Spolverato, Ylenia, Esposito, Marialusia, Isernia, Roberta Maria, Di Salvo, Maria, Manunza, Romina, Esposito, Giuseppe, Agus, Marcello, Asti, Emanuele Luigi Giuseppe, Bernardi, Daniele Tiziano, Tonucci, Tommaso Panici, Luppi, Davide, Casadei, Massimiliano, Bonilauri, Stefano, Pezzolla, Angela, Panebianco, Annunziata, Laforgia, Rita, De Luca, Maurizio, Zese, Monica, Parini, Dario, Jovine, Elio, De Sario, Giuseppina, Lombardi, Raffaele, Aprea, Giovanni, Palomba, Giuseppe, Capuano, Marianna, Argenio, Giulio, Orio, Gianluca, Armellino, Mariano Fortunato, Troian, Marina, Guerra, Martina, Nagliati, Carlo, Biloslavo, Alan, Germani, Paola, Aizza, Giada, Monsellato, Igor, Chahrour, Ali Chaouki, Anania, Gabriele, Bombardini, Cristina, Bagolini, Francesco, Sganga, Gabriele, Fransvea, Pietro, Bianchi, Valentina, Boati, Paolo, Ferrara, Francesco, Palmieri, Francesco, Cianci, Pasquale, Gattulli, Domenico, Restini, Enrico, Cillara, Nicola, Cannavera, Alessandro, Nita, Gabriela Elisa, Sarnari, Jlenia, Roscio, Francesco, Clerici, Federico, Scandroglio, Ildo, Berti, Stefano, Cadeo, Alessandro, Filippelli, Alice, Conti, Luigi, Grassi, Carmine, Cattaneo, Gaetano Maria, Pighin, Marina, Papis, Davide, Gambino, Giovanni, Bertino, Vanessa, Schifano, Domenico, Prando, Daniela, Fogato, Luisella, Cavallo, Fabio, Ansaloni, Luca, Picheo, Roberto, Pontarolo, Nicholas, Depalma, Norma, Spampinato, Marcello, D’Ugo, Stefano, Lepre, Luca, Capponi, Michela Giulii, Campa, Rossella Domenica, Sarro, Giuliano, Dinuzzi, Vincenza Paola, Olmi, Stefano, Uccelli, Matteo, Ferrari, Davide, Inama, Marco, Moretto, Gianluigi, Fontana, Michele, Favi, Francesco, Picariello, Erika, Rampini, Alessia, Barberis, Andrea, Azzinnaro, Antonio, Oliva, Alba, Totaro, Luigi, Benzoni, Ilaria, Ranieri, Valerio, Capolupo, Gabriella Teresa, Carannante, Filippo, Caricato, Marco, Ronconi, Maurizio, Casiraghi, Silvia, Casole, Giovanni, Pantalone, Desire, Alemanno, Giovanni, Scheiterle, Maximilian, Ceresoli, Marco, Cereda, Marco, Fumagalli, Chiara, Zanzi, Federico, Bolzon, Stefano, Guerra, Enrico, Lecchi, Francesca, Cellerino, Paola, Ardito, Antonella, Scaramuzzo, Rosa, Balla, Andrea, Lepiane, Pasquale, Tartaglia, Nicola, Ambrosi, Antonio, Pavone, Giovanna, Palini, Gian Marco, Veneroni, Simone, Garulli, Gianluca, Ricci, Claudio, Torre, Beatrice, Russo, Iris Shari, Rottoli, Matteo, Tanzanu, Marta, Belvedere, Angela, Milone, Marco, Manigrasso, Michele, De Palma, Giovanni Domenico, Piccoli, Micaela, Pattacini, Gianmaria Casoni, Magnone, Stefano, Bertoli, Paolo, Pisano, Michele, Massucco, Paolo, Palisi, Marco, Luzzi, Andrea-Pierre, Fleres, Francesco, Clarizia, Guglielmo, Spolini, Alessandro, Kobe, Yoshiro, Toma, Takayuki, Shimamura, Fumihiko, Parker, Robert, Ranketi, Sinkeet, Mitei, Mercy, Svagzdys, Saulius, Pauzas, Henrikas, Zilinskas, Justas, Poskus, Tomas, Kryzauskas, Marius, Jakubauskas, Matas, Zakaria, Andee Dzulkarnaen, Zakaria, Zaidi, Wong, Michael Pak-Kai, Jusoh, Asri Che, Zakaria, Muhammad Nazreen, Cruz, Daniel Rios, Elizalde, Aurea Barbara Rodriguez, Reynaud, Alejandro Bañon, Hernandez, Edgard Efren Lozada, Monroy, Jose maria Victor Palomo, Hinojosa-Ugarte, Diego, Quiodettis, Martha, Du Bois, María Esther, Latorraca, José, Major, Piotr, Pędziwiatr, Michał, Pisarska-Adamczyk, Magdalena, Walędziak, Maciej, Kwiatkowski, Andrzej, Czyżykowski, Łukasz, da Costa, Silvia Dantas, Pereira, Bela, Ferreira, Ana Rita Oliveira, Almeida, Filipe, Rocha, Ricardo, Carneiro, Carla, Perez, Diego Pita, Carvas, João, Rocha, Catarina, Ferreira, Cátia, Marques, Rita, Fernandes, Urânia, Leao, Pedro, Goulart, André, Pereira, Rita Gonçalves, Patrocínio, Sara Daniela Direito, de Mendonça, Nuno Gonçalo Gonçalves, Manso, Maria Isabel Cerqueira, Morais, Henrique Manuel Cardoso, Cardoso, Paulo Sebastião, Calu, Valentin, Miron, Adrian, Toma, Elena Adelina, Gachabayov, Mahir, Abdullaev, Abakar, Litvin, Andrey, Nechay, Taras, Tyagunov, Alexander, Yuldashev, Anvar, Bradley, Alison, Wilson, Michael, Panyko, Arpád, Látečková, Zuzana, Lacko, Vladimír, Lesko, Dusan, Soltes, Marek, Radonak, Jozef, Turrado-Rodriguez, Victor, Termes-Serra, Roser, Morales-Sevillano, Xavier, Lapolla, Pierfrancesco, Mingoli, Andrea, Brachini, Gioia, Degiuli, Maurizio, Sofia, Silvia, Reddavid, Rossella, de Manzoni Garberini, Andrea, Buffone, Angelica, del Pozo, Eduardo Perea, Aparicio-Sánchez, Daniel, Dos Barbeito, Sandra, Estaire-Gómez, Mercedes, Vitón-Herrero, Rebeca, de los Ángeles Gil Olarte-Marquez, Mª, Gil-Martínez, José, Alconchel, Felipe, Nicolás-López, Tatiana, Rahy-Martin, Aida Cristina, Pelloni, María, Bañolas-Suarez, Raquel, Mendoza-Moreno, Fernando, Nisa, Francisca García-Moreno, Díez-Alonso, Manuel, Rodas, María Elisa Valle, Agundez, María Carmona, Andrés, María Inmaculada Pérez, Moreira, Claudia Cristina Lopes, Perez, Aintzane Lizarazu, Ponce, Iñigo Augusto, González-Castillo, Ana María, Membrilla-Fernández, Estela, Salvans, Silvia, Serradilla-Martín, Mario, Pardo, Pablo Sancho, Rivera-Alonso, Daniel, Dziakova, Jana, Huguet, Jose Mugüerza, Valle, Naila Pagès, Ruiz, Enrique Colás, Valcárcel, Cristina Rey, Moreno, Cristina Ruiz, Salazar, Yeniffer Tatiana Moreno, García, Juan Jesús Rubio, Micó, Silvia Sevila, López, Joaquín Ruiz, Farré, Silvia Pérez, Gomez, Maite Santamaria, Petit, Nuria Mestres, Titos-García, Alberto, Aranda-Narváez, Jose Manuel, Romacho-López, Laura, Sánchez-Guillén, Luis, Aranaz-Ostariz, Veronica, Bosch-Ramírez, Marina, Martínez-Pérez, Aleix, Martínez-López, Elías, Sebastián-Tomás, Juan Carlos, Jimenez-Riera, Granada, Jimenez-Vega, Javier, Cuellar, Jose Aurelio Navas, Campos-Serra, Andrea, Muñoz-Campaña, Anna, Gràcia-Roman, Raquel, Alegre, Javier Martínez, Pinto, Francisca Lima, O’Sullivan, Sara Nuñez, Antona, Francisco Blanco, Jiménez, Beatriz Muñoz, López-Sánchez, Jaime, Carmona, Zahira Gómez, Fernández, Rocio Torres, Sierra, Isabel Blesa, de León, Laura Román García, Moreno, Verónica Polaino, Iglesias, Eva, Cumplido, Paola Lora, Bravo, Altea Arango, Simó, Ignacio Rey, Domínguez, Carlota López, Caamaño, Aloia Guerreiro, Lozano, Rafael Calleja, Martínez, Manuel Durán, Torres, Álvaro Naranjo, de Quiros, Javier Tomas Morales Bernaldo, Pellino, Gianluca, Cloquell, Miriam Moratal, Moller, Elsa García, Jalal-Eldin, Sami, Abdoun, Ahmed K., Hamid, Hytham K. S., Lohsiriwat, Varut, Mongkhonsupphawan, Aitsariya, Baraket, Oussama, Ayed, Karim, Abbassi, Imed, Ali, Ali Ben, Ammar, Houssem, Kchaou, Ali, Tlili, Ahmed, Zribi, Imen, Colak, Elif, Polat, Suleyman, Koylu, Zehra Alan, Guner, Ali, Usta, Mehmet Arif, Reis, Murat Emre, Mantoglu, Baris, Gonullu, Emre, Akin, Emrah, Altintoprak, Fatih, Bayhan, Zulfu, Firat, Necattin, Isik, Arda, Memis, Ufuk, Bayrak, Mehmet, Altıntaş, Yasemin, Kara, Yasin, Bozkurt, Mehmet Abdussamet, Kocataş, Ali, Das, Koray, Seker, Ahmet, Ozer, Nazmi, Atici, Semra Demirli, Tuncer, Korhan, Kaya, Tayfun, Ozkan, Zeynep, Ilhan, Onur, Agackiran, Ibrahim, Uzunoglu, Mustafa Yener, Demirbas, Eren, Altinel, Yuksel, Meric, Serhat, Hacım, Nadir Adnan, Uymaz, Derya Salim, Omarov, Nail, Balık, Emre, Tebala, Giovanni D., Khalil, Hany, Rana, Mridul, Khan, Mansoor, Florence, Charlotte, Swaminathan, Christie, Leo, Cosimo Alex, Liasis, Lampros, Watfah, Josef, Trostchansky, Ivan, Delgado, Edward, Pontillo, Marcelo, Latifi, Rifat, Coimbra, Raul, Edwards, Sara, Lopez, Ana, Velmahos, George, Dorken, Ander, Gebran, Anthony, Palmer, Amanda, Oury, Jeffrey, Bardes, James M., Seng, Sirivan Suon, Coffua, Lauren S., Ratnasekera, Asanthi, Egodage, Tanya, Echeverria-Rosario, Karla, Armento, Isabella, Napolitano, Lena M., Sangji, Naveen F., Hemmila, Mark, Quick, Jacob A., Austin, Tyler R., Hyman, Theodore S., Curtiss, William, McClure, Amanda, Cairl, Nicholas, Biffl, Walter L., Truong, Hung P., Schaffer, Kathryn, Reames, Summer, Banchini, Filippo, Capelli, Patrizio, Coccolini, Federico, Sartelli, Massimo, Bravi, Francesca, Vallicelli, Carlo, Agnoletti, Vanni, Baiocchi, Gian Luca, and Catena, Fausto

Published
2024
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20. Impact of an integrated health, nutrition, and early child stimulation and responsive care intervention package delivered to preterm or term small for gestational age babies during infancy on growth and neurodevelopment: study protocol of an individually randomized controlled trial in India (Small Babies Trial)

Author

Chowdhury, Ranadip, Manapurath, Rukman, Sandøy, Ingvild Fossgard, Upadhyay, Ravi Prakash, Dhabhai, Neeta, Shaikh, Saijuddin, Chellani, Harish, Choudhary, Tarun Shankar, Jain, Abhinav, Martines, Jose, Bhandari, Nita, Strand, Tor A., and Taneja, Sunita

Published
2024
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21. Bartonella quintana Infection in Kidney Transplant Recipients from Donor Experiencing Homelessness, United States, 2022

Author

Amy M. Beeson, Shannan N. Rich, Michael E. Russo, Julu Bhatnagar, Rebecca N. Kumar, Jana M. Ritter, Pallavi Annambhotla, Moe R. Takeda, Kira F. Kuhn, Prishanya Pillai, Marlene DeLeon-Carnes, Rebecca Scobell, Maheswari Ekambaram, Rachel Finkel, Sarah Reagan-Steiner, Roosecelis B. Martines, Rohit S. Satoskar, Gayle M. Vranic, Raji Mohammed, Gloria E. Rivera, Kumarasen Cooper, Heba Abdelal, Marc Roger Couturier, Benjamin T. Bradley, Alison F. Hinckley, Jane E. Koehler, Paul S. Mead, Matthew J. Kuehnert, Joel Ackelsberg, Sridhar V. Basavaraju, and Grace E. Marx

Subjects
Bartonella quintana, transplant, homelessness, bacteria, United States, Medicine, Infectious and parasitic diseases, RC109-216
Abstract

Bartonella quintana infection can cause severe disease that includes clinical manifestations such as endocarditis, chronic bacteremia, and vasoproliferative lesions of the skin and viscera. B. quintana bacteria is transmitted by the human body louse (Pediculus humanus corporis) and is associated with homelessness and limited access to hygienic services. We report B. quintana infection in 2 kidney transplant recipients in the United States from an organ donor who was experiencing homelessness. One infection manifested atypically, and the other was minimally symptomatic; with rapid detection, both recipients received timely treatment and recovered. B. quintana was identified retrospectively in an archived donor hematoma specimen, confirming the transmission link. Information about the organ donor’s housing status was critical to this investigation. Evaluation for B. quintana infection should be considered for solid organ transplant recipients who receive organs from donors with a history of homelessness or of body lice infestation.

Published
2024
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22. Efficacy and safety of TiF4 varnish in preventing erosive tooth wear in a rat animal model

Author

Mariele Vertuan, Júlia França da Silva, Aline Dionizio, Beatriz Martines de Souza, Victor Mosquim, Tatiana Martini, Gustavo Pompermaier Garlet, Samira Helena Niemeyer, Marcella Esteves-Oliveira, and Ana Carolina Magalhães

Subjects
Erosion, Fluoride, Tooth erosion, Titanium, Medicine, Science
Abstract

Abstract An animal model was applied to develop erosive tooth wear (ETW) and to evaluate the efficacy and safety of titanium tetrafluoride (TiF4) in preventing ETW. Forty-eight male Wistar rats were divided into three groups (n = 16): TiF4 (2.45% F−), NaF (2.45% F−) and placebo varnishes. Eight from each group were subjected to erosive challenges (Sprite Zero) and the other received tap water, both ad libitum. After twenty-eight days, the mandibles were resected for histopathological gingival analysis, clinical and microscopic tooth evaluation by 3D confocal laser microscopy, scanning electron microscopy (SEM-EDX) and micro-Raman spectroscopy (MRS). Organs were evaluated with respect to fluoride content. No significant difference was found in F content in tissues. No histopathological damage was seen in gingiva. ETW was clinically more aggressive in rats from placebo group consuming Sprite compared to water (Q²=12.6, p

Published
2024
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23. Critical analysis of the ULF power depression as a possible Tohoku earthquake precursorKey points

Author

Vyacheslav A. Pilipenko, Valery A. Martines-Bedenko, Akimasa Yoshikawa, and Kirolosse M. Girgis

Subjects
earthquake forecast, seismo-electromagnetic phenomena, ultra-low frequency (ULF) pulsations, Geology, QE1-996.5
Abstract

Among electromagnetic methods of short-term earthquake prediction, an approach is being actively developed based on the phenomenon of magnetic ultra-low-frequency (ULF) power depression occurring a few days before an earthquake. In particular, a nighttime geomagnetic power depression in the band 0.03–0.05 Hz was observed approximately 5 days before the catastrophic Tohoku 2011 earthquake. To verify the reliability of this method, we performed an extended analysis using data from magnetometer arrays JMA, MAGDAS, PWING, and INTERMAGNET. The selected stations included sites close to the epicenter (

Published
2024
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26. Impact of the presence and number of chromosomal abnormalities on the clinical outcome in Waldenström Macroglobulinemia: a monocentric experience

Author

Danesin, Nicolò, Bonaldi, Laura, Martines, Annalisa, Nalio, Silvia, Bertorelle, Roberta, Compagno, Sofia, Marcato, Raffaella, Manni, Sabrina, Scarmozzino, Federico, Pizzi, Marco, Tos, Angelo Paolo Dei, Cellini, Alessandro, Scapinello, Greta, Visentin, Andrea, Trentin, Livio, and Piazza, Francesco

Published
2024
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27. Impact of dimension-eight SMEFT operators in the EWPO and Triple Gauge Couplings analysis in Universal SMEFT

Author

Corbett, Tyler, Desai, Jay, Eboli, O. J. P., Gonzalez-Garcia, M. C., Martines, Matheus, and Reimitz, Peter

Subjects
High Energy Physics - Phenomenology
Abstract

We perform a complete study of the electroweak precision observables and electroweak gauge boson pair production in terms of the SMEFT up to ${\cal O}(1/\Lambda^4)$ under the assumption of universal, C and P conserving new physics. We show that the analysis of data from those two sectors allows us to obtain closed constraints in the relevant parameter space in this scenario. In particular we find that the Large Hadron Collider data can independently constrain the Wilson coefficients of the dimension-six and -eight operators directly contributing to the triple gauge boson vertices. Our results show that the impact of dimension-eight operators in the study of triple gauge couplings is small., Comment: 17 pages and 3 figures

Published
2023
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28. Organizational purpose in practice: impact on the meaning of work and employee engagement

Author

Rosiane Moreira Machado Batista and Vanessa Martines Cepellos

Subjects
propósito organizacional, empresas orientadas para o propósito, sentido do trabalho, engajamento, lideranças orientadas para o propósito, Management. Industrial management, HD28-70, Business, HF5001-6182
Abstract

This article aims to analyze how organizational purpose influences the meaning of work and employee engagement. The article is relevant due to the scarcity of studies on the subject, but also because organizations have faced numerous challenges linked to new ways of working, resignations from professionals who are looking for greater personal and professional fulfillment, among other factors that impact the meaning of work and employee engagement. Given this scenario, this article makes contributions as it identifies: (i) how the phenomenon “organizational purpose” manifests itself in practice; (ii) its relevance; (iii) its positive impact on the meaning of work and engagement and (iv) the importance of the role of leadership in this process. To achieve the objective of this work, ten semi-structured, qualitative research studies were carried out, using the thematic analysis technique to process the data. The study concludes that: (i) the organizational purpose needs to be authentic; (ii) that there is a direct relationship between a company with an organizational purpose and the positive impact it generates on the meanings of work; (iii) the organizational purpose is the “differentiator” in engagement; (iv) and leadership is a driver and guardian of purpose.

Published
2024
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29. Relapsed Mpox Keratitis, St. Louis, Missouri, USA

Author

Cinthia Pi, Osasu Adah, Preetam A. Cholli, Roosecelis Martines, Getahun Abate, Lori Hainaut, Erich Seipel, T. Scott Isbell, Roddy Frankel, and Nongnooch Poowanawittayakom

Subjects
ocular mpox, mpox keratitis, ocular syphilis, HIV, AIDS, monkeypox, Medicine, Infectious and parasitic diseases, RC109-216
Abstract

We describe a case of a 46-year-old man in Missouri, USA, with newly diagnosed advanced HIV and PCR-confirmed mpox keratitis. The keratitis initially resolved after intravenous tecovirimat and penicillin for suspected ocular syphilis coinfection. Despite a confirmatory negative PCR, he developed relapsed, ipsilateral PCR-positive keratitis and severe ocular mpox requiring corneal transplant.

Published
2024
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33. ASSISTENCIA DURANTE O TRABALHO DE PARTO E PÓS-PARTO

Author

HUGO JÚLIO DA ROSA, VICTOR, primary, FRANCISCO DE MELO, CARLOS, additional, NOÊMIA SOUZA DE ALCÂNTARA, MARIA, additional, LEMES DO PRADO FILHO, LEANDRO, additional, FEITOSA GAZEL, WELLESON, additional, CRISTHIANE GOMES DE SOUSA COSTA, KEVINLLY, additional, VITÓRIA MORAES DA SILVA, MACELLA, additional, SANTOS MARACAIPE, MIRIELLY, additional, DA SILVA MELO, MARYANA, additional, FERREIRA MARQUES, LILIANE, additional, ALVES SOUSA, JONATHAS, additional, PORTILHO FRAGA, HIURY, additional, STOCKLER RAVASCHIERI MARTINOLLI, TARSILIA, additional, EDUARDA PIRES MARTINES, MARIA, additional, and SANTOS DA SILVA, ELANE, additional

Published
2024
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34. Sensorless MPPT Algorithms for PV Systems in Partially Shaded Scenarios

Author

Guilherme M. S. Martines, Moacyr A. G. de Brito, Edson A. Batista, Ruben B. Godoy, and Tiago H. A. Mateus

Subjects
MPPT, sensorless, metaheuristic, reduced cost, partial shading conditions, photovoltaic arrays, Electrical engineering. Electronics. Nuclear engineering, TK1-9971
Abstract

This manuscript presents current sensorless algorithms for maximum power point tracking (MPPT) in partially shaded photovoltaic (PV) systems. The necessity of a current sensor is eliminated with the use of mathematical modeling of the power electronics converter. This approach significantly reduces the implementation cost and the inherent disadvantages in the current sensor circuitry. MPPT techniques based on soft computing are employed, in addition to Perturb and Observe (P&O), due to their ability to explore a larger search space. This feature is advantageous because it minimizes convergence risk to a local maximum, a limitation of traditional techniques. Simulation and experimental results are presented and each algorithm is evaluated through different metrics, such as search time for the global maximum power point (GMPP) and efficiency. The tests consider dynamic irradiance profiles, producing a tracking factor (TF) above 99% and a remarkable fast convergence time.

Published
2024
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35. OR-17 - AVALIAÇÃO DA ATIVIDADE DE G6PD E SUAS CARACTERÍSTICAS EPIDEMIOLÓGICAS EM INDIVÍDUOS COM DIAGNÓSTICO DE MALÁRIA

Author

Mayara Gonçalves Tavares, Alexia Martines V. Silva, Dhelio Batista Pereira, and Mariana Pinheiro A. Vasconcelos

Subjects
Infectious and parasitic diseases, RC109-216, Microbiology, QR1-502
Abstract

Introdução: A deficiência de glicose-6-fosfato desidrogenase (G6PD) afeta cerca de 400 milhões de pessoas no mundo, na Amazônia brasileira foi descrita uma prevalência de 5,6%. É uma desordem enzimática, e torna a hemácia suscetível à injúria oxidativa após contato com antimaláricos, como a primaquina e tafenoquina. Sendo de fundamental importância na região amazônica, que corresponde a 99% dos casos de malária do Brasil. Objetivo: Avaliar a atividade de G6PD e suas características epidemiológicas em indivíduos com diagnóstico de malária. Método: Foram avaliadas as características epidemiológicas e exame de G6PD dos indivíduos com diagnóstico de malária por P. vivax (incluindo mista PV+PF) atendidos no ambulatório de síndromes febris do Centro de Pesquisa em Medicina Tropical de Rondônia (CEPEM), em Porto Velho, em 2022. Aprovado pelo CEP/CEPEM. Resultados: Avaliamos 2.066 casos de P. vivax, com média de idade de 38 anos (0,6-85 anos; DP 15,8), 1.385 (67%) do sexo masculino. Do sexo feminino, 13 (1,9%) eram gestantes e 30 (4,4%) lactantes. Todos realizaram o teste de G6PD, sendo 206 (10%) com baixa atividade (≤ 4,0), 656 (31,7%) com atividade intermediária (≥ 4,1 e ≤ 6,0) e 1.204 (58,3%) atividade normal (≥ 6,1), (p > 0,013). Dentre os homens (n = 1.385) a atividade de G6PD foi: 125 (9%) baixa, 465 (33,6%) intermediária e 795 (57,4%) normal, já as mulheres (n = 681), 81 (11,9%) apresentaram baixa atividade, 191 (28%) intermediária e 409 (60,1%) normal. Os pacientes foram tratados com os seguintes esquemas: 980 (47,4%) com primaquina 7 dias; 570 (27,6%) tafenoquina, 295 (14,3%) com primaquina 14 dias; e 205 (9,9%) primaquina semanal. A proporção de recaída foi de 255 (12,3%), sendo 7,3% com primaquina semanal e 12,9% com outros esquemas, além disso, não houve diferença estatística na média de peso de quem apresentou recaída quando comparada a quem não apresentou (p = 0,352). Conclusão: A prevalência de deficiência de G6PD foi maior (10% versus 5,6%) quando comparado a estudos anteriores na Amazônia brasileira. O Ministério da Saúde prevê a implementação da tafenoquina, mostramos que mais de 40% dos indivíduos analisados teriam contraindicação à tafenoquina. Dessa forma, reforçamos a importância da testagem de G6PD prévia à administração de antimaláricos, a fim de evitar complicações. Nos casos de deficiência vimos que o esquema semanal não aumentou as recaídas. Demonstramos que, apesar de relacionada ao cromossomo X, não houve diferença estatística de deficiência ao comparar os sexos.

Published
2024
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36. OR-18 - ANÁLISE DA PREVALÊNCIA DE METAHEMOGLOBINA, SEUS NÍVEIS E MANIFESTAÇÕES CLÍNICAS

Author

Alexia Martines V. Silva, Thaina Monique G.S. Luz, Rafaela Soares Silva, Mariana Pinheiro A. Vasconcelos, and Dhelio Batista Pereira

Subjects
Infectious and parasitic diseases, RC109-216, Microbiology, QR1-502
Abstract

Introdução: Visando diminuir recaídas, o tratamento da malária foi modificado aumentando a dose diária da primaquina e reduzindo o tempo de tratamento. Essa estratégia parece ter aumentado episódios de metahemoglobinemia, ações oxidantes nas hemoglobinas, transformando as em metemoglobina (metaHb), que não possuem capacidade de transporte de oxigênio aos tecidos. Objetivo: Analisar a prevalência de metemoglobina, seus níveis e manifestações clínicas. Método: Os participantes foram atendidos no ambulatório de malária do Centro de Pesquisa em Medicina Tropical de Rondônia, em Porto Velho, no período de 2022 a 2023, com diagnóstico de metahemoglobinemia (MetaHB > 3,0%) em seus retornos. Foram avaliados níveis de metemoglobina e aspectos clínicos. Aprovado pelo CEP/CEPEM. Resultados: Foram atendidos 5330 indivíduos e analisados 556 participantes com metahemoglobinemia (10,4%), com média de idade de 39 anos (DP 16), 68,2% eram do sexo masculino. Eram primoinfecção 135 indivíduos, destes 80,7% apresentavam valor de metaHb 5 (p < 0,001). 496 indivíduos retornaram em menos de 15 dias do diagnóstico de malária e 66,5% apresentavam metaHb > 5 (p < 0,001). Conclusão: As manifestações clínicas estão diretamente relacionadas aos níveis de MetaHb. Entretanto, os sintomas estão presentes quando MetaHB < 10%, divergindo de estudos que sugerem o início dos sintomas com valor superior a 12%. É fundamental que os profissionais de saúde tenham conhecimento sobre a metaHb como complicação do tratamento de malária (10,4%), principalmente nas regiões endêmicas. O diagnóstico pode ser um desafio sem o auxílio do co-oximetro, mas características clínicas podem ser fundamentais.

Published
2024
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37. EP-001 - DESCRIÇÃO DAS CARACTERÍSTICAS CLÍNICAS EM PACIENTES INTERNADOS COM METAEMOGLOBINEMIA

Author

Alexia Martines V. Silva, Joyce Karolina D. Melo, Ellyda Etheline Torres Noronha, Dhelio Batista Pereira, and Mariana Pinheiro A. Vasconcelos

Subjects
Infectious and parasitic diseases, RC109-216, Microbiology, QR1-502
Abstract

Introdução: A malária é uma das doenças infecto-parasitárias de maior importância no mundo. A metahemoglobinemia é uma das principais complicações relacionada a terapêutica medicamentosa para o P. vivax com derivados 8-aminoquinolinas, como primaquina e tafenoquina. O acesso a métodos diagnósticos nem sempre estão disponíveis, o que se faz necessário suspeita clínica. Objetivo: Descrever as características clínicas em pacientes internados com metaemoglobinemia. Método: Foram atendidas 4.541 pessoas com malária no hospital Cemetron, em Porto Velho, entre os anos de 2019 e 2023, e apenas 60 destes pacientes apresentaram diagnóstico clínico e/ou laboratorial de metahemoglobinemia. Foram avaliados dados clínicos e laboratoriais durante toda a internação. Aprovação CEP/CEPEM (CAAE 68890523.4.0000.0011). Resultados: Dos 4.541 indivíduos internados, 60 tiveram diagnóstico de metahemoglobinemia (1,3%). Dos 60 com diagnóstico de metahemoglobinemia, a média de idade foi de 33 anos, sendo 36 (60%) do sexo masculino. Todos foram internados já com complicações da terapeutica, sendo os seguintes esquemas: 43 (71,6%) primaquina 7 dias, 10 (16,6%) primaquina 14 dias, 1 (1,6%) tafenoquina, 1 (1,6%) primaquina semanal e 5 (8,3%) sem informação. Em 58,4% dos casos, houve necessidade de interromper teraperutica e 3,3% teve esquema modificado. Dos indivíduos que tiveram avaliação da metemoglobina (metaHb), 65,2% apresentaram valor > 10. Dos sintomas apresentados, 42 (70%) tinham dispneia, 28 (46,6%) cefaleia, 27 (45%) fraqueza, 21 (35%) cianose, 19 (31,6%) vômito. Com relação a oximetria, os valores variaram de 65-93%, sendo que 39 (65%) indivíduos receberam suplementação de O², sendo 19 (49%) por máscara de alto fluxo, 11 (28%) por cateter nasal, 8 (20,5%) por máscara de Venturi e 1 (2,5%) por ventilação mecânica. O tempo médio de internação foi de 6,1 dias, e não foi registrado nenhum óbito. Conclusão: Encontramos uma baixa prevalência de metahemoglobinemia com necessidade de internação, porém 65% dos que internaram tiveram necessidade de suplementação de O2, inclusive com ventilação mecânica. É uma complicação que diagnosticada precocemente e com a interrupção ou modificação do esquema para semanal, pode modificar desfecho, como vimos em outro estudo do nosso grupo com acompanhamento ambulatorial.

Published
2024
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38. REVISÃO BIBLIOGRÁFICA DA EFICÁCIA DO RUSFERTIDE EM PACIENTES COM POLICITEMIA VERA

Author

GG Terra, GB Giardini, HAX Borsato, MM Fernandes, M Martines, LD Calderan, LGF Souza, and JVDS Bianchi

Subjects
Diseases of the blood and blood-forming organs, RC633-647.5
Abstract

Objetivos: Investigar a eficácia terapêutica de um fármaco mimético da hepcidina, Rusfertide, que tem sido pesquisado como uma opção inovadora na restauração da homeostase em diversos distúrbios hematológicos, inclusive na Policitemia Vera (PV). Metodologia: Revisão de literatura realizada em junho de 2024, utilizando as plataformas Pubmed. Foi adotado como filtro, publicações de 2020 a 2024 e encontrados 100 artigos. Desses, foram utilizados 10 artigos, que estão disponíveis na íntegra e publicados em inglês. Resultados: Após análise de estudos com pacientes que possuem PV leve e severa, foi observado que a taxa de Flebotomia terapêutica (FT) decaiu após as primeiras semanas com o uso do fármaco. Todos os pacientes apresentaram efeitos adversos, variando em graus de severidade, onde os de grau leve apresentaram reações no local da injeção (eritema), mas foi controlada ao decorrer do tratamento, e a variação do número de leucócitos, onde parte dos pacientes apresentaram valores normais da série branca e outra apresentou uma leucocitose sem causa aparente. Já os pacientes com efeitos adversos graves, foi observado uma trombocitose assintomática, Leucemia Mieloide Aguda e infarto do miocárdio, em PV severa. Além disso, todos os pacientes em tratamento apresentaram uma redução do hematócrito (Ht) para 45% em que anteriormente apresentaram valores superiores a 55% e 43% dos indivíduos estudados tiveram uma redução da frequência de FT. Discussão: A PV é uma neoplasia mieloproliferativa crônica caracterizada por uma mutação pontual no gene JAK2, que resulta na produção excessiva de células sanguíneas e está associada a complicações graves, como trombose e hemorragia. Os tratamentos convencionais, como a FT e as terapias citorredutoras, causam limitações e não aliviam adequadamente os sintomas dos pacientes. Com o objetivo de proporcionar uma melhor qualidade de vida e um controle mais eficaz da doença, foi desenvolvido o Rusfertide, um fármaco injetável que mimetiza a hepcidina, responsável pela regulação do ferro no organismo. Está sendo testado em ensaios clínicos para pacientes que dependem de FT. Esta nova abordagem tem demonstrado resultados encorajadores, como a capacidade de controlar o Ht, diminuir a frequência de FT necessárias e aliviar sintomas. O tratamento tem benefícios, pois houve o controle da neoplasia da maioria dos pacientes em tratamento. Além disso, a FT diminuiu ou cessou em todos os pacientes após o início do tratamento com Rusfertide, independentemente da categoria de risco de PV ou de tratamentos concomitantes. Essa redução do número de FT, além de possuir vantagens terapêuticas, também pode aumentar a qualidade de vida do paciente, visto que a necessidade de monitoramento constante e procedimentos invasivos limita a sua autonomia. Portanto, é sugestivo que a terapia possa melhorar o controle do Ht e diminuir o uso da FT. Conclusão: Apesar das reações adversas e da necessidade de mais pesquisas, devido a melhora da qualidade de vida do paciente, o tratamento com o Rusfertide se mostra promissor. Este fármaco pode se tornar uma ferramenta adicional para o controle desta doença, a partir de seu mecanismo de ação, que irá atingir e sustentar o controle do Ht em pacientes com PV, reduzindo o uso de FT e a ocorrência de sintomas debilitantes relacionados à doença.

Published
2024
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39. NOVA TERAPIA PARA LEUCEMIA LINFOBLÁSTICA AGUDA: UMA ANÁLISE COMPARATIVA ENTRE IMUNOTERAPIAS

Author

GG Terra, GB Giardini, LD Calderan, M Martines, and DJVDS Bianchi

Subjects
Diseases of the blood and blood-forming organs, RC633-647.5
Abstract

Objetivos: Realizar uma comparação entre a eficácia terapêutica do Tercartus, que tem sido uma descoberta para o tratamento de Leucemia Linfoblástica Aguda (LLA) em contrapartida com a já utilizada terapia com Mesilato de Imatinibe. Metodologia: Revisão de literatura realizada em junho de 2024, utilizando as plataformas Pubmed e Clinical Trials. Foi adotado como filtro, publicações de 2020 a 2024. Dessas, foram utilizados 10 artigos, que atendiam aos critérios de serem disponíveis gratuitamente na íntegra e publicados em inglês. Resultados: Atualmente, há em andamento 8 estudos clínicos no Clinical Trials e 23 artigos no PubMed sobre os efeitos do Tercartus em pacientes adultos com LLA do tipo B recidiva ou refratária. Em um estudo realizado com 55 pacientes, foram acompanhados por 26,8 meses e observado uma taxa de remissão completa (RC) de 56% e quando a RC associado a recuperação hematológica incompleta foi obtido uma taxa de 71%. Houve uma resposta por parte dos pacientes para o Tecartus independente da idade ou porcentagem de blastos, porém quando analisado pacientes com números maiores que 75% de blastos não houve essa resposta. Quando analisados os eventos adversos, não ocorreu nenhum de grau severo, como a síndrome de liberação de citocinas. Assim, é possível se analisar que a imunoterapia fornece um benefício de sobrevivência clinicamente significativo com toxicidade gerenciável. Discussão: No final de 2023, a ANVISA aprovou o Tecartus, seu princípio ativo é o Brexucabtagene autoleucel e promove a morte de células que expressam o CD19 (células B neoplásicas), a partir da ativação e proliferação de células T e a secreção de interleucinas, com o intuito de levar a morte da célula. Entre as neoplasias que visam tratar, destaca-se a LLA de células B precursoras recidivante ou refratária. Por mais que já existam terapias disponíveis no mercado que vêm sendo utilizadas para o tratamento dessa neoplasia, como o Imatinibe, o Tecartus vem buscando se mostrar promissor para ser um novo medicamento para o tratamento da LLA. Em comparação com o tratamento com Imatinibe, que é um inibidor da atividade de proteína tirosina quinase do gene de fusão BCR-ABL da LLA, foi observado em estudos que para obter melhores taxas de sucesso e entrar em remissão e posteriormente impedir uma recidiva, deve-se fazer a associação dele com quimioterapia agressiva. Foi observado também uma grande quantidade de reações adversas, como dor abdominal e hemorragia gastrointestinal. Entretanto, os benefícios foram muitos, cerca de 62% dos pacientes mostraram aumento na taxa de remissão clínica completa. A terapia com Tecartus, no geral, tem se mostrado bastante eficaz, porém a taxa de RC foi menor quando comparado ao uso de Imatinibe. Com isso, sugere-se que o Imatinibe traz maiores benefícios em relação ao novo tratamento, apesar de possuir um tratamento a longo prazo, devido sua administração via oral, enquanto para o Tecartus é necessário uma única infusão e é necessário a associação com quimioterapia. Conclusão: Apesar de ter apresentado menor taxa de RC ao Imatinibe, o Tecartus é uma terapia promissora que faz aumentar a sobrevida global mediana e promove uma RC da neoplasia em parte dos pacientes, mesmo sendo necessário realizar quimioterapia concomitante à infusão.

Published
2024
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40. Presentation

Author

Josep Martines Peres, Sandra Montserrat Buendia, and Jordi M. Antolí Martínez

Subjects
Philology. Linguistics, P1-1091
Abstract

Presentation of the Catalan Journal of Linguistics 23: Semantic Change in Grammaticalization.

Published
2024
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41. Clinicopathological discrepancies in the diagnoses of childhood causes of death in the CHAMPS network: An analysis of antemortem diagnostic inaccuracies

Author

Khatia Munguambe, Quique Bassat, Robert F Breiman, Mahbubur Rahman, Sibone Mocumbi, Cynthia G Whitney, Amy Wise, Shams El Arifeen, Meerjady Sabrina Flora, Soter Ameh, Emily S Gurley, Mustafizur Rahman, Ariel Nhacolo, Carla Carrilho, Cheick Bougadari Traore, Lucy Liu, Inacio Mandomando, Clara Menendez, Chris A Rees, Janet Agaya, Jane Juma, Tadesse Gure, George Aol, Hennie Lombaard, Ziyaad Dangor, Shabir Madhi, James Bunn, Samba O Sow, Dickson Gethi, Sanwarul Bari, Jeffrey P Koplan, Natalia Rakislova, Fabiola Fernandes, Tacilta Nhampossa, Maria Maixenchs, Mohammed Kamal, Nega Assefa, Joseph Oundo, Lola Madrid, Tahmina Shirin, Nelesh P Govender, Addisu Alemu, Hailemariam Legesse, Uma U Onwuchekwa, Awa Traore, Portia C Mutevedzi, Victor Akelo, Sammy Khagayi, Dickens Onyango, Richard Omore, Yasmin Adam, Peter Otieno, Margaret Mannah, Vicky Baillie, Karen L Kotloff, John Blevins, Milagritos D Tapia, Rima Koka, Mohammad Zahid Hossain, Dickens Kowuor, Tom Sesay, James Squire, Francis Moses, Haleluya Leulseged, Christine Bethencourt, Kitiezo Aggrey Igunza, Ikechukwu U Ogbuanu, Andrew Moseray, Ima-Abasi Bassey, Afruna Rahman, Muntasir Alam, Yasir Y Abdullahi, Nana Kourouma, Seydou Sissoko, Rosauro Varo, Sana Mahtab, Martin Hale, Jeanie du Toit, Zachary J Madewell, Dianna M Blau, Roosecelis B Martines, Fatima Solomon, Gillian Sorour, Jeannette Wadula, Karen Petersen, Peter J Swart, Sanjay G Lala, Sithembiso Velaphi, Richard Chawana, Ashleigh Fritz, Nellie Myburgh, Pedzisai Ndagurwa, Cleopas Hwinya, Shahana Parveen, ASM Nawshad Uddin Ahmed, Mahbubul Hoque, Saria Tasnim, Ferdousi Islam, Farida Ariuman, Mohammad Mosiur Rahman, Ferdousi Begum K Zaman, Dilruba Ahmed, Alexander M Ibrahim, Fikremelekot Temesgen, Melisachew Mulatu Yeshi, Mahlet Abayneh Gizaw, Stian MS Orlien, Solomon Ali, Peter Nyamthimba Onyango, Richard Oliech, Joyce Akinyi Were, Thomas Misore, Harun Owuor, Christopher Muga, Bernard Oluoch, Christine Ochola, Sharon M Tennant, Carol L Greene, Ashka Mehta, J Kristie Johnson, Brigitte Gaume, Adama Mamby Keita, Karen D Fairchild, Diakaridia Kone, Diakaridia Sidibe, Doh Sanogo, Kounandji Diarra, Tiéman Diarra, Kiranpreet Chawla, Zara Manhique, Fatmata Bintu Tarawally, Martin Seppeh, Ronald Mash, Julius Ojulong, Babatunde Duduyemi, Alim Swaray-Deen, Joseph Bangura Amara Jambai, Okokon Ita, Cornell Chukwuegbo, Sulaiman Sannoh, Princewill Nwajiobi, Erick Kaluma, Oluseyi Balogun, Carrie Jo Cain, Solomon Samura, Samuel Pratt, Joseph Kamanda Sesay, Osman Kaykay, Binyam Halu, Francis Smart, Sartie Kenneh, Jana Ritter, Tais Wilson, Jonas Winchell, Jakob Witherbee, Navit T Salzberg, Margaret Basket, Ashutosh Wadhwa, Kyu Han Lee, Roosecelis Martines, Shamta Warang, Maureen Diaz, Jessica Waller, Shailesh Nair, Courtney Bursuc, Kristin LaHatte, Sarah Raymer, Solveig Argeseanu, Kurt Vyas, and Manu Bhandari

Subjects
Pediatrics, RJ1-570
Abstract

Introduction Determining aetiology of severe illness can be difficult, especially in settings with limited diagnostic resources, yet critical for providing life-saving care. Our objective was to describe the accuracy of antemortem clinical diagnoses in young children in high-mortality settings, compared with results of specific postmortem diagnoses obtained from Child Health and Mortality Prevention Surveillance (CHAMPS).Methods We analysed data collected during 2016–2022 from seven sites in Africa and South Asia. We compared antemortem clinical diagnoses from clinical records to a reference standard of postmortem diagnoses determined by expert panels at each site who reviewed the results of histopathological and microbiological testing of tissue, blood, and cerebrospinal fluid. We calculated test characteristics and 95% CIs of antemortem clinical diagnostic accuracy for the 10 most common causes of death. We classified diagnostic discrepancies as major and minor, per Goldman criteria later modified by Battle.Results CHAMPS enrolled 1454 deceased young children aged 1–59 months during the study period; 881 had available clinical records and were analysed. The median age at death was 11 months (IQR 4–21 months) and 47.3% (n=417) were female. We identified a clinicopathological discrepancy in 39.5% (n=348) of deaths; 82.3% of diagnostic errors were major. The sensitivity of clinician antemortem diagnosis ranged from 26% (95% CI 14.6% to 40.3%) for non-infectious respiratory diseases (eg, aspiration pneumonia, interstitial lung disease, etc) to 82.2% (95% CI 72.7% to 89.5%) for diarrhoeal diseases. Antemortem clinical diagnostic specificity ranged from 75.2% (95% CI 72.1% to 78.2%) for diarrhoeal diseases to 99.0% (95% CI 98.1% to 99.6%) for HIV.Conclusions Antemortem clinical diagnostic errors were common for young children who died in areas with high childhood mortality rates. To further reduce childhood mortality in resource-limited settings, there is an urgent need to improve antemortem diagnostic capability through advances in the availability of diagnostic testing and clinical skills.

Published
2024
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43. Peer Coaching Program Development: A Framework of First-Year Latina/o Student Persistence Pursuing STEM Pathways at a Hispanic Serving Institution

Author

Cruz, Carmen, Rajpal, Geetu, Lecocke, Michael, Martines, Ian, and Lurie, Anna

Abstract

This study developed and examined the implementation of an intrusive peer-to-peer coaching program model at a private 4-year master's degree granting Hispanic Serving Institution (HSI) located in South Texas. The coaching program provided support and promoted increased persistence among Latina/o students entering first-year science, technology, engineering, and mathematics (STEM). Findings positively indicated that first-year Latina/o STEM students can achieve academic success in college when they are matched and supported by culturally similar upperclassmen peer coaches.

Published
2021
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46. How does atmospheric pressure cold helium plasma affect the biomechanical behaviour on alkali-lesioned corneas?

Author

Simona Neri, Maria Vittoria Mascolini, Antonella Peruffo, Silvia Todros, Matteo Zuin, Luigi Cordaro, Emilio Martines, Barbara Contiero, Emanuele Luigi Carniel, Ilaria Iacopetti, Marco Patruno, Chiara Giulia Fontanella, and Anna Perazzi

Subjects
Porcine cornea, Plasma treatment, Cross-linking, Biomechanics, Ex vivo animal model, Veterinary medicine, SF600-1100
Abstract

Abstract Background Melting corneal ulcers are a serious condition that affects a great number of animals and people around the world and it is characterised by a progressive weakening of the tissue leading to possible severe ophthalmic complications, such as visual impairment or blindness. This disease is routinely treated with medical therapy and keratoplasty, and recently also with alternative regenerative therapies, such as cross-linking, amniotic membrane transplant, and laser. Plasma medicine is another recent example of regenerative treatment that showed promising results in reducing the microbial load of corneal tissue together with maintaining its cellular vitality. Since the effect of helium plasma application on corneal mechanical viscoelasticity has not yet been investigated, the aim of this study is first to evaluate it on ex vivo porcine corneas for different exposition times and then to compare the results with previous data on cross-linking treatment. Results 94 ex vivo porcine corneas divided into 16 populations (healthy or injured, fresh or cultured and treated or not with plasma or cross-linking) were analysed. For each population, a biomechanical analysis was performed by uniaxial stress-relaxation tests, and a statistical analysis was carried out considering the characteristic mechanical parameters. In terms of equilibrium normalised stress, no statistically significant difference resulted when the healthy corneas were compared with lesioned plasma-treated ones, independently of treatment time, contrary to what was obtained about the cross-linking treated corneas which exhibited more intense relaxation phenomena. Conclusions In this study, the influence of the Helium plasma treatment was observed on the viscoelasticity of porcine corneas ex vivo, by restoring in lesioned tissue a degree of relaxation similar to the one of the native tissue, even after only 2 min of application. Therefore, the obtained results suggest that plasma treatment is a promising new regenerative ophthalmic therapy for melting corneal ulcers, laying the groundwork for further studies to correlate the mechanical findings with corneal histology and ultrastructural anatomy after plasma treatment.

Published
2024
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47. Goodbye Hartmann trial: a prospective, international, multicenter, observational study on the current use of a surgical procedure developed a century ago

Author

Gennaro Perrone, Mario Giuffrida, Fikri Abu-Zidan, Vitor F. Kruger, Marco Livrini, Gabriele Luciano Petracca, Giorgio Rossi, Antonio Tarasconi, Brian W. C. A. Tian, Elena Bonati, Ricardo Mentz, Federico N. Mazzini, Juan P. Campana, Elisabeth Gasser, Reinhold Kafka-Ritsch, Daniel M. Felsenreich, Christopher Dawoud, Stefan Riss, Carlos Augusto Gomes, Felipe Couto Gomes, Ricardo Alessandro Teixeira Gonzaga, Cassio Alfred Brattig Canton, Bruno Monteiro Pereira, Gustavo P. Fraga, Leticia Gonçalves Zem, Vinicius Cordeiro-Fonseca, Renato de Mesquita Tauil, Boyko Atanasov, Nikolay Belev, Nikola Kovachev, L. Juan José Meléndez, Ana Dimova, Stefan Dimov, Zdravko Zelić, Goran Augustin, Branko Bogdanić, Trpimir Morić, Elie Chouillard, Melinda Bajul, Belinda De Simone, Yves Panis, Francesco Esposito, Margherita Notarnicola, Lelde Lauka, Anna Fabbri, Hassen Hentati, Iskander Fnaiech, Venara Aurélien, Marie Bougard, Maxime Roulet, Zaza Demetrashvili, Irakli Pipia, Giorgi Merabishvili, Konstantinos Bouliaris, Georgios Koukoulis, Christos Doudakmanis, Sofia Xenaki, Emmanuel Chrysos, Stamatios Kokkinakis, Panteleimon Vassiliu, Nikolaos Michalopoulos, Ioannis Margaris, Aristotelis Kechagias, Konstantinos Avgerinos, Jevgeni Katunin, Eftychios Lostoridis, Eleni-Aikaterini Nagorni, Antonio Pujante, Francesk Mulita, Ioannis Maroulis, Michail Vailas, Athanasios Marinis, Ioannis Siannis, Eirini Bourbouteli, Dimitrios K. Manatakis, Nikolaos Tasis, Vasileios Acheimastos, Sotiropoulou Maria, Kapiris Stylianos, Harilaos Kuzeridis, Dimitrios Korkolis, Evangelos Fradelos, George Kavalieratos, Thalia Petropoulou, Andreas Polydorou, Ioannis Papacostantinou, Tania Triantafyllou, Despina Kimpizi, Dimitrios Theodorou, Konstantinos Toutouzas, Alexandros Chamzin, Maximos Frountzas, Dimitrios Schizas, Ioannis Karavokyros, Athanasios Syllaios, Alexandros Charalabopoulos, Maria Boura, Efstratia Baili, Orestis Ioannidis, Lydia Loutzidou, Elissavet Anestiadou, Ioannis Tsouknidas, Georgios Petrakis, Eleni Polenta, Lovenish Bains, Rahul Gupta, Sudhir K. Singh, Archana Khanduri, Miklosh Bala, Asaf Kedar, Marcello Pisano, Mauro Podda, Adolfo Pisanu, Gennaro Martines, Giuseppe Trigiante, Giuliano Lantone, Antonino Agrusa, Giuseppe Di Buono, Salvatore Buscemi, Massimiliano Veroux, Rossella Gioco, Gastone Veroux, Luigi Oragano, Sandro Zonta, Federico Lovisetto, Carlo V. Feo, Antonio Pesce, Nicolò Fabbri, Giulio Lantone, Fabio Marino, Fabrizio Perrone, Leonardo Vincenti, Vincenzo Papagni, Arcangelo Picciariello, Stefano Rossi, Biagio Picardi, Simone Rossi Del Monte, Diego Visconti, Giulia Osella, Luca Petruzzelli, Giusto Pignata, Jacopo Andreuccetti, Rossella D’Alessio, Massimo Buonfantino, Eleonora Guaitoli, Stefano Spinelli, Gianluca Matteo Sampietro, Carlo Corbellini, Leonardo Lorusso, Alice Frontali, Isabella Pezzoli, Alessandro Bonomi, Andrea Chierici, Christian Cotsoglou, Giuseppe Manca, Antonella Delvecchio, Nicola Musa, Massimiliano Casati, Laface Letizia, Emmanuele Abate, Giorgio Ercolani, Fabrizio D’Acapito, Leonardo Solaini, Gianluca Guercioni, Simone Cicconi, Diego Sasia, Felice Borghi, Giorgio Giraudo, Giuseppe Sena, Pasquale Castaldo, Eugenia Cardamone, Giuseppe Portale, Matteo Zuin, Ylenia Spolverato, Marialusia Esposito, Roberta Maria Isernia, Maria Di Salvo, Romina Manunza, Giuseppe Esposito, Marcello Agus, Emanuele Luigi Giuseppe Asti, Daniele Tiziano Bernardi, Tommaso Panici Tonucci, Davide Luppi, Massimiliano Casadei, Stefano Bonilauri, Angela Pezzolla, Annunziata Panebianco, Rita Laforgia, Maurizio De Luca, Monica Zese, Dario Parini, Elio Jovine, Giuseppina De Sario, Raffaele Lombardi, Giovanni Aprea, Giuseppe Palomba, Marianna Capuano, Giulio Argenio, Gianluca Orio, Mariano Fortunato Armellino, Marina Troian, Martina Guerra, Carlo Nagliati, Alan Biloslavo, Paola Germani, Giada Aizza, Igor Monsellato, Ali Chaouki Chahrour, Gabriele Anania, Cristina Bombardini, Francesco Bagolini, Gabriele Sganga, Pietro Fransvea, Valentina Bianchi, Paolo Boati, Francesco Ferrara, Francesco Palmieri, Pasquale Cianci, Domenico Gattulli, Enrico Restini, Nicola Cillara, Alessandro Cannavera, Gabriela Elisa Nita, Jlenia Sarnari, Francesco Roscio, Federico Clerici, Ildo Scandroglio, Stefano Berti, Alessandro Cadeo, Alice Filippelli, Luigi Conti, Carmine Grassi, Gaetano Maria Cattaneo, Marina Pighin, Davide Papis, Giovanni Gambino, Vanessa Bertino, Domenico Schifano, Daniela Prando, Luisella Fogato, Fabio Cavallo, Luca Ansaloni, Roberto Picheo, Nicholas Pontarolo, Norma Depalma, Marcello Spampinato, Stefano D’Ugo, Luca Lepre, Michela Giulii Capponi, Rossella Domenica Campa, Giuliano Sarro, Vincenza Paola Dinuzzi, Stefano Olmi, Matteo Uccelli, Davide Ferrari, Marco Inama, Gianluigi Moretto, Michele Fontana, Francesco Favi, Erika Picariello, Alessia Rampini, Andrea Barberis, Antonio Azzinnaro, Alba Oliva, Luigi Totaro, Ilaria Benzoni, Valerio Ranieri, Gabriella Teresa Capolupo, Filippo Carannante, Marco Caricato, Maurizio Ronconi, Silvia Casiraghi, Giovanni Casole, Desire Pantalone, Giovanni Alemanno, Maximilian Scheiterle, Marco Ceresoli, Marco Cereda, Chiara Fumagalli, Federico Zanzi, Stefano Bolzon, Enrico Guerra, Francesca Lecchi, Paola Cellerino, Antonella Ardito, Rosa Scaramuzzo, Andrea Balla, Pasquale Lepiane, Nicola Tartaglia, Antonio Ambrosi, Giovanna Pavone, Gian Marco Palini, Simone Veneroni, Gianluca Garulli, Claudio Ricci, Beatrice Torre, Iris Shari Russo, Matteo Rottoli, Marta Tanzanu, Angela Belvedere, Marco Milone, Michele Manigrasso, Giovanni Domenico De Palma, Micaela Piccoli, Gianmaria Casoni Pattacini, Stefano Magnone, Paolo Bertoli, Michele Pisano, Paolo Massucco, Marco Palisi, Andrea-Pierre Luzzi, Francesco Fleres, Guglielmo Clarizia, Alessandro Spolini, Yoshiro Kobe, Takayuki Toma, Fumihiko Shimamura, Robert Parker, Sinkeet Ranketi, Mercy Mitei, Saulius Svagzdys, Henrikas Pauzas, Justas Zilinskas, Tomas Poskus, Marius Kryzauskas, Matas Jakubauskas, Andee Dzulkarnaen Zakaria, Zaidi Zakaria, Michael Pak-Kai Wong, Asri Che Jusoh, Muhammad Nazreen Zakaria, Daniel Rios Cruz, Aurea Barbara Rodriguez Elizalde, Alejandro Bañon Reynaud, Edgard Efren Lozada Hernandez, Jose maria Victor Palomo Monroy, Diego Hinojosa-Ugarte, Martha Quiodettis, María Esther Du Bois, José Latorraca, Piotr Major, Michał Pędziwiatr, Magdalena Pisarska-Adamczyk, Maciej Walędziak, Andrzej Kwiatkowski, Łukasz Czyżykowski, Silvia Dantas da Costa, Bela Pereira, Ana Rita Oliveira Ferreira, Filipe Almeida, Ricardo Rocha, Carla Carneiro, Diego Pita Perez, João Carvas, Catarina Rocha, Cátia Ferreira, Rita Marques, Urânia Fernandes, Pedro Leao, André Goulart, Rita Gonçalves Pereira, Sara Daniela Direito Patrocínio, Nuno Gonçalo Gonçalves de Mendonça, Maria Isabel Cerqueira Manso, Henrique Manuel Cardoso Morais, Paulo Sebastião Cardoso, Valentin Calu, Adrian Miron, Elena Adelina Toma, Mahir Gachabayov, Abakar Abdullaev, Andrey Litvin, Taras Nechay, Alexander Tyagunov, Anvar Yuldashev, Alison Bradley, Michael Wilson, Arpád Panyko, Zuzana Látečková, Vladimír Lacko, Dusan Lesko, Marek Soltes, Jozef Radonak, Victor Turrado-Rodriguez, Roser Termes-Serra, Xavier Morales-Sevillano, Pierfrancesco Lapolla, Andrea Mingoli, Gioia Brachini, Maurizio Degiuli, Silvia Sofia, Rossella Reddavid, Andrea de Manzoni Garberini, Angelica Buffone, Eduardo Perea del Pozo, Daniel Aparicio-Sánchez, Sandra Dos Barbeito, Mercedes Estaire-Gómez, Rebeca Vitón-Herrero, Mª de los Ángeles Gil Olarte-Marquez, José Gil-Martínez, Felipe Alconchel, Tatiana Nicolás-López, Aida Cristina Rahy-Martin, María Pelloni, Raquel Bañolas-Suarez, Fernando Mendoza-Moreno, Francisca García-Moreno Nisa, Manuel Díez-Alonso, María Elisa Valle Rodas, María Carmona Agundez, María Inmaculada Pérez Andrés, Claudia Cristina Lopes Moreira, Aintzane Lizarazu Perez, Iñigo Augusto Ponce, Ana María González-Castillo, Estela Membrilla-Fernández, Silvia Salvans, Mario Serradilla-Martín, Pablo Sancho Pardo, Daniel Rivera-Alonso, Jana Dziakova, Jose Mugüerza Huguet, Naila Pagès Valle, Enrique Colás Ruiz, Cristina Rey Valcárcel, Cristina Ruiz Moreno, Yeniffer Tatiana Moreno Salazar, Juan Jesús Rubio García, Silvia Sevila Micó, Joaquín Ruiz López, Silvia Pérez Farré, Maite Santamaria Gomez, Nuria Mestres Petit, Alberto Titos-García, Jose Manuel Aranda-Narváez, Laura Romacho-López, Luis Sánchez-Guillén, Veronica Aranaz-Ostariz, Marina Bosch-Ramírez, Aleix Martínez-Pérez, Elías Martínez-López, Juan Carlos Sebastián-Tomás, Granada Jimenez-Riera, Javier Jimenez-Vega, Jose Aurelio Navas Cuellar, Andrea Campos-Serra, Anna Muñoz-Campaña, Raquel Gràcia-Roman, Javier Martínez Alegre, Francisca Lima Pinto, Sara Nuñez O’Sullivan, Francisco Blanco Antona, Beatriz Muñoz Jiménez, Jaime López-Sánchez, Zahira Gómez Carmona, Rocio Torres Fernández, Isabel Blesa Sierra, Laura Román García de León, Verónica Polaino Moreno, Eva Iglesias, Paola Lora Cumplido, Altea Arango Bravo, Ignacio Rey Simó, Carlota López Domínguez, Aloia Guerreiro Caamaño, Rafael Calleja Lozano, Manuel Durán Martínez, Álvaro Naranjo Torres, Javier Tomas Morales Bernaldo de Quiros, Gianluca Pellino, Miriam Moratal Cloquell, Elsa García Moller, Sami Jalal-Eldin, Ahmed K. Abdoun, Hytham K. S. Hamid, Varut Lohsiriwat, Aitsariya Mongkhonsupphawan, Oussama Baraket, Karim Ayed, Imed Abbassi, Ali Ben Ali, Houssem Ammar, Ali Kchaou, Ahmed Tlili, Imen Zribi, Elif Colak, Suleyman Polat, Zehra Alan Koylu, Ali Guner, Mehmet Arif Usta, Murat Emre Reis, Baris Mantoglu, Emre Gonullu, Emrah Akin, Fatih Altintoprak, Zulfu Bayhan, Necattin Firat, Arda Isik, Ufuk Memis, Mehmet Bayrak, Yasemin Altıntaş, Yasin Kara, Mehmet Abdussamet Bozkurt, Ali Kocataş, Koray Das, Ahmet Seker, Nazmi Ozer, Semra Demirli Atici, Korhan Tuncer, Tayfun Kaya, Zeynep Ozkan, Onur Ilhan, Ibrahim Agackiran, Mustafa Yener Uzunoglu, Eren Demirbas, Yuksel Altinel, Serhat Meric, Nadir Adnan Hacım, Derya Salim Uymaz, Nail Omarov, Emre Balık, Giovanni D. Tebala, Hany Khalil, Mridul Rana, Mansoor Khan, Charlotte Florence, Christie Swaminathan, Cosimo Alex Leo, Lampros Liasis, Josef Watfah, Ivan Trostchansky, Edward Delgado, Marcelo Pontillo, Rifat Latifi, Raul Coimbra, Sara Edwards, Ana Lopez, George Velmahos, Ander Dorken, Anthony Gebran, Amanda Palmer, Jeffrey Oury, James M. Bardes, Sirivan Suon Seng, Lauren S. Coffua, Asanthi Ratnasekera, Tanya Egodage, Karla Echeverria-Rosario, Isabella Armento, Lena M. Napolitano, Naveen F. Sangji, Mark Hemmila, Jacob A. Quick, Tyler R. Austin, Theodore S. Hyman, William Curtiss, Amanda McClure, Nicholas Cairl, Walter L. Biffl, Hung P. Truong, Kathryn Schaffer, Summer Reames, Filippo Banchini, Patrizio Capelli, Federico Coccolini, Massimo Sartelli, Francesca Bravi, Carlo Vallicelli, Vanni Agnoletti, Gian Luca Baiocchi, and Fausto Catena

Subjects
Hartmann’s procedure, Ostomy, Emergency surgery, Resection, Primary anastomosis, Left side, Surgery, RD1-811, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
Abstract

Abstract Background Literature suggests colonic resection and primary anastomosis (RPA) instead of Hartmann’s procedure (HP) for the treatment of left-sided colonic emergencies. We aim to evaluate the surgical options globally used to treat patients with acute left-sided colonic emergencies and the factors that leading to the choice of treatment, comparing HP and RPA. Methods This is a prospective, international, multicenter, observational study registered on ClinicalTrials.gov. A total 1215 patients with left-sided colonic emergencies who required surgery were included from 204 centers during the period of March 1, 2020, to May 31, 2020. with a 1-year follow-up. Results 564 patients (43.1%) were females. The mean age was 65.9 ± 15.6 years. HP was performed in 697 (57.3%) patients and RPA in 384 (31.6%) cases. Complicated acute diverticulitis was the most common cause of left-sided colonic emergencies (40.2%), followed by colorectal malignancy (36.6%). Severe complications (Clavien-Dindo ≥ 3b) were higher in the HP group (P

Published
2024
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