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5 results on '"Martina M. Bertschinger"'

1. Microparticles and their impact on intestinal immunity

Author

Martina M. Bertschinger, Gerhard Rogler, Helen M. Becker, University of Zurich, and Becker, Helen M

Subjects
Inflammasomes, Inflammation, 610 Medicine & health, Biology, Microbiology, Proinflammatory cytokine, medicine, Animals, Humans, Secretion, 2715 Gastroenterology, Gastroenterology, Pattern recognition receptor, technology, industry, and agriculture, Immunity, Interleukin, Inflammasome, General Medicine, Inflammatory Bowel Diseases, Intestines, 10219 Clinic for Gastroenterology and Hepatology, Food, Nanoparticles, Interleukin 18, medicine.symptom, Intracellular, medicine.drug
Abstract

Microparticles are small (2), the latter being a white pigment used in toothpaste or sugar toppings. The increasing abundance of microparticles in the Western diet raises the question of the potential risks associated with gastrointestinal diseases such as Crohn’s disease (CD). Accumulation of particles has been shown in cells of Peyer’s patches, but it is not clear whether this also has pathological effects. NLRP3 is a member of the intracellular pattern recognition receptor family and it is part of the inflammasome, a multiprotein complex containing caspase-1 which activates the proinflammatory cytokines interleukin (IL)-1β and IL-18. With regard to recent findings identifying small particles such as asbestos and monosodium urate as NLRP3 activators, TiO2 may be another potential target for inflammasome studies. We found that macrophage-like cells readily take up TiO2 after 6 h. Incubation of cells with TiO2 resulted in the assembly of NLRP3 with caspase-1. This inflammasome assembly correlated with secretion of IL-1β. In intestinal epithelial cells, TiO2 also was found to be ingested. The counting of particles localized intracellularly revealed a dose-dependent increase of TiO2-positive cells. This points to the fact that in humans with a leaky intestinal barrier (such as IBD patients), TiO2 microparticles may be taken up by macrophages and intestinal epithelial cells, may activate the inflammasome and induce IL-1β and IL-18 secretion. This may aggravate inflammation in susceptible individuals.

Published
2012

2. Subject Index Vol. 30, Suppl. 3, 2012

Author

Eduard F. Stange, Florian Rieder, Patricia Lepage, Joël Doré, Robert Ehehalt, Remo Panaccione, Christopher J. Hawkey, Ole Haagen Nielsen, Charles N. Bernstein, Edouard Louis, Helen M. Becker, Christoph Mueller, Max Karner, Druck Reinhardt Druck Basel, Tomas de Wouters, Jacob Tveiten Bjerrum, Kim L. Isaacs, Martina M. Bertschinger, Luc Biedermann, Wolfgang Stremmel, Andrea Mohr, Volker Gross, Laurent Peyrin-Biroulet, Sabine Staffer, William J. Sandborn, Sabine Stoffels, Claudio Fiocchi, Jakob Benedict Seidelin, Gerhard Rogler, Subra Kugathasan, Bruce E. Sands, Caroline Nyberg, Annika Braun, Millie D. Long, Jean-Frederic Colombel, Hans H Herfarth, Stephan R. Vavricka, Satz Mengensatzproduktion, Michael Scharl, Mark A. Ainsworth, Camille Zallot, and Wolfgang Kruis

Subjects
medicine.medical_specialty, Index (economics), business.industry, Gastroenterology, Physical therapy, Medicine, Subject (documents), General Medicine, business
Published
2012

3. Dealing with Our ‘In-Vironment’: New Aspects of Inflammatory Bowel Disease Pathogenesis and Therapy

Author

Mark A. Ainsworth, Martina M. Bertschinger, Sabine Staffer, Michael Scharl, Luc Biedermann, Jean-Frederic Colombel, Annika Braun, Christoph Mueller, Wolfgang Kruis, Jacob Tveiten Bjerrum, Jakob Benedict Seidelin, Millie D. Long, Bruce E. Sands, Wolfgang Stremmel, Andrea Mohr, Max Karner, Sabine Stoffels, Laurent Peyrin-Biroulet, Kim L. Isaacs, Satz Mengensatzproduktion, Subra Kugathasan, Claudio Fiocchi, Hans H Herfarth, Edouard Louis, Helen M. Becker, Caroline Nyberg, Camille Zallot, Tomas de Wouters, Eduard F. Stange, Volker Gross, Robert Ehehalt, Patricia Lepage, William J. Sandborn, Christopher J. Hawkey, Ole Haagen Nielsen, Stephan R. Vavricka, Gerhard Rogler, Charles N. Bernstein, Florian Rieder, Joël Doré, Remo Panaccione, and Druck Reinhardt Druck Basel

Subjects
Pathogenesis, business.industry, Immunology, Gastroenterology, Medicine, General Medicine, business, medicine.disease, Inflammatory bowel disease
Published
2012

4. [Panhypopituitarism, Diabetes Insipidus and Bone Pain - Is There a Systemic Disease Behind it?]

Author

Bertschinger M, Sze L, Bosma I, Dommann-Scherrer C, and Goede J

Subjects
Male, Humans, Adult, Positron Emission Tomography Computed Tomography, Pain etiology, Hypopituitarism diagnosis, Hypopituitarism etiology, Diabetes Insipidus diagnosis, Diabetes Insipidus etiology, Diabetes Mellitus
Abstract

Introduction: A 27-year-old man presented due to unilateral leg pain. He had a history of diabetes insipidus and panhypopituitarism. Laboratory analysis revealed hormonal undersupply. MRI showed a large contrast medium-absorbing mass in the pituitary gland extending into the hypothalamus. FDG-PET/CT examination revealed a hypermetabolic soft tissue lesion around the left femoral shaft. After biopsy of the lesion, a diagnosis of multisystemic Langerhans cell histiocytosis was made., Competing Interests: Es bestehen keine Interessenskonflikte., (© 2024 Aerzteverlag medinfo AG.)

Published
2024

5. Severe refeeding syndrome after human chorionic gonadotropin diet: a potentially lethal complication.

Author

Schunemann MJ, Bertschinger M, Trachsel C, and Bachli E

Subjects
Chorionic Gonadotropin, Diet, Humans, Male, Hypokalemia etiology, Hypophosphatemia etiology, Refeeding Syndrome etiology
Abstract

We present the case of a young male patient who presented with paralysing muscle weakness due to severe hypokalaemia and hypophosphataemia. The initial patient history evaluations could not establish the aetiology. Only after we reviewed the patient's history did he reveal that he had been following a severe calorie-restricted regime, the human chorionic gonadotropin diet, which had ended 2 days prior to developing symptoms. This information then allowed us to diagnose severe refeeding syndrome. As a further complication, the patient developed rhabdomyolysis. After correction of serum electrolytes, symptoms resolved completely. This case emphasises the potential harm of severely calorie-restricted diets, often recommended by online 'experts'. Furthermore, we underline the importance of thorough history taking., Competing Interests: Competing interests: None declared., (© BMJ Publishing Group Limited 2021. No commercial re-use. See rights and permissions. Published by BMJ.)

Published
2021
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