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115 results on '"Martin-de-Carpi, Javier"'

1. STEP-CD study: ustekinumab use in paediatric Crohn’s disease—a multicentre retrospective study from paediatric IBD Porto group of ESPGHAN

Author

Pujol-Muncunill, Gemma, Navas-López, Víctor Manuel, Ledder, Oren, Cohen, Shlomi, Lekar, Marina, Turner, Dan, Kolho, Kaija-Leena, Levine, Arie, Croft, Nicholas M., Bronsky, Jiri, Shouval, Dror S., Assa, Amit, Harris, Rachel, Kiparissi, Fevronia, Aloi, Marina, Afzal, Nadeem Ahmad, Tzivinikos, Christos, Barrio, Josefa, Norden, Christoph, Vega, Maria Jesús Balboa, Buderus, Stephan, de Valderrama, Ana Fernández, de Ridder, Lissy, García-Romero, Ruth, Medina, Enrique, Sánchez, César, Velasco, Marta, Vicente, Saioa, Wilson, David C., Naik, Sandhia, Hradsky, Ondrej, Cococcioni, Lucia, and Martin-de-Carpi, Javier

Published
2024
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4. Safety and effectiveness of vedolizumab in paediatric patients with inflammatory bowel disease: an observational multicentre Spanish study

Author

Garcia-Romero, Ruth, Martinez de Zabarte Fernandez, José Miguel, Pujol-Muncunill, Gemma, Donat-Aliaga, Ester, Segarra-Cantón, Oscar, Irastorza-Terradillos, Iñaki, Medina-Benitez, Enrique, Ruiz-Hernández, Carlos José, Carrillo-Palau, Marta, Ros-Arnal, Ignacio, Rodriguez-Martínez, Alejandro, Escartin-Madurga, Laura, Gutiérrez-Junquera, Carolina, Vicente-Santamaría, Saioa, Velasco Rodriguez-Belvis, Marta, Fernández-Fernández, Sonia, Alberto-Alonso, José Ramón, Montraveta, Montserrat, Torres-Peral, Ricardo, Navalon-Rubio, María, Navas-López, Víctor Manuel, and Martin de Carpi, Javier

Published
2021
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5. Predicting Outcomes in Pediatric Ulcerative Colitis for Management Optimization: Systematic Review and Consensus Statements From the Pediatric Inflammatory Bowel Disease–Ahead Program

Author

Orlanski-Meyer, Esther, Aardoom, Martine, Ricciuto, Amanda, Navon, Dan, Carman, Nicholas, Aloi, Marina, Bronsky, Jiri, Däbritz, Jan, Dubinsky, Marla, Hussey, Séamus, Lewindon, Peter, Martin De Carpi, Javier, Navas-López, Víctor Manuel, Orsi, Marina, Ruemmele, Frank M., Russell, Richard K., Veres, Gabor, Walters, Thomas D., Wilson, David C., Kaiser, Thomas, de Ridder, Lissy, Griffiths, Anne, and Turner, Dan

Published
2021
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6. Predicting Outcomes in Pediatric Crohn’s Disease for Management Optimization: Systematic Review and Consensus Statements From the Pediatric Inflammatory Bowel Disease–Ahead Program

Author

Ricciuto, Amanda, Aardoom, Martine, Orlanski-Meyer, Esther, Navon, Dan, Carman, Nicholas, Aloi, Marina, Bronsky, Jiri, Däbritz, Jan, Dubinsky, Marla, Hussey, Séamus, Lewindon, Peter, Martín De Carpi, Javier, Navas-López, Víctor Manuel, Orsi, Marina, Ruemmele, Frank M., Russell, Richard K., Veres, Gabor, Walters, Thomas D., Wilson, David C., Kaiser, Thomas, de Ridder, Lissy, Turner, Dan, and Griffiths, Anne M.

Published
2021
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11. Dual Biologic or Small Molecule Therapy in Refractory Pediatric Inflammatory Bowel Disease (DOUBLE-PIBD): A Multicenter Study from the Pediatric IBD Porto Group of ESPGHAN.

Author

Yerushalmy-Feler, Anat, Olbjorn, Christine, Kolho, Kaija-Leena, Aloi, Marina, Musto, Francesca, Martin-de-Carpi, Javier, Lozano-Ruf, Ana, Yogev, Dotan, Matar, Manar, Scarallo, Luca, Bramuzzo, Matteo, Ridder, Lissy de, Kang, Ben, Norden, Christoph, Wilson, David C, Tzivinikos, Christos, Turner, Dan, and Cohen, Shlomi

Published
2024
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15. Pediatric Magnet Ingestion, Diagnosis, Management, and Prevention: A European Society for Paediatric Gastroenterology Hepatology and Nutrition (ESPGHAN) Position Paper

Author

Nugud, A A, Tzivinikos, Christos, Assa, Amit, Borrelli, Osvaldo, Broekaert, Ilse, Martin-de-Carpi, Javier, Deganello Saccomani, Marco, Dolinsek, Jernej, Homan, M, Mas, Emmanuel, Miele, Erasmo, Thomson, Mike, Benninga, Marc A, Nugud, A A, Tzivinikos, Christo, Assa, Amit, Borrelli, Osvaldo, Broekaert, Ilse, Martin-de-Carpi, Javier, Deganello Saccomani, Marco, Dolinsek, Jernej, Homan, M, Mas, Emmanuel, Miele, Erasmo, Thomson, Mike, and Benninga, Marc A

Abstract

Magnet ingestion is a special category of foreign body ingestion associated with high levels of morbidity and mortality worldwide, particularly if it is associated with staggered ingestion of multiple magnets or with simultaneous ingestion of other metallic foreign bodies, especially button batteries. A special category of magnet ingestion is the ingestion of earth magnets, which have higher levels of magnetism and therefore, potentially, carries a worse outcome. Legislative bodies, scientific Societies and community-led initiatives have been implemented worldwide with the aim of mitigating the effects of this growing, yet avoidable potential medical emergency. A scoping literature review summarized epidemiology, diagnosis, management, and prevention, including an algorithm for the diagnosis and management of magnet ingestion is presented and compared to previously published reviews and position papers (North American Society of Pediatric Gastroenterology, Hepatology and Nutrition, National Poison Center, Royal College of Emergency Medicine). The main emphasis of the algorithm is on identification of staggered/multiple magnet ingestion, and early joint gastroenterology and surgical consultation and management.

Published
2023

20. Development, Validation, and Evaluation of the Pediatric Inflammatory Crohn’s Magnetic Resonance Enterography Index From the ImageKids Study

Author

Focht, Gili, primary, Cytter-Kuint, Ruth, additional, Greer, Mary-Louise C., additional, Pratt, Li-Tal, additional, Castro, Denise A., additional, Church, Peter C., additional, Walters, Thomas D., additional, Hyams, Jeffrey, additional, Navon, Dan, additional, Martin de Carpi, Javier, additional, Ruemmele, Frank, additional, Russell, Richard K., additional, Gavish, Matan, additional, Griffiths, Anne M., additional, and Turner, Dan, additional

Published
2022
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21. Safety and Potential Efficacy of Escalating Dose of Ustekinumab in Pediatric Crohn Disease (the Speed-up Study): A Multicenter Study from the Pediatric IBD Porto Group of ESPGHAN

Author

Yerushalmy-Feler, Anat, primary, Pujol-Muncunill, Gemma, additional, Martin-de-Carpi, Javier, additional, Kolho, Kaija-Leena, additional, Levine, Arie, additional, Olbjørn, Christine, additional, Granot, Maya, additional, Bramuzzo, Matteo, additional, Rolandsdotter, Helena, additional, Mouratidou, Natalia, additional, Hradsky, Ondrej, additional, Scarallo, Luca, additional, Matar, Manar, additional, Rimon, Ramit Magen, additional, Rinawi, Firas, additional, Shalem, Tzippi, additional, Najajra, Hisham, additional, de Meij, Tim, additional, Aloi, Marina, additional, Rodríguez-Belvís, Marta Velasco, additional, Alvisi, Patrizia, additional, Schneider, Anna-Maria, additional, van Rheenen, Patrick, additional, Navas-López, Víctor Manuel, additional, Kiparissi, Fevronia, additional, Barrio, Josefa, additional, Turner, Dan, additional, and Cohen, Shlomi, additional

Published
2022
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22. Vedolizumab in Paediatric Inflammatory Bowel Disease: A Retrospective Multi-Centre Experience From the Paediatric IBD Porto Group of ESPGHAN

Author

Ledder, Oren, Assa, Amit, Levine, Arie, Escher, Johanna C, de Ridder, Lissy, Ruemmele, Frank, Shah, Neil, Shaoul, Ron, Wolters, Victorien M, Rodrigues, Astor, Uhlig, Holm H, Posovsky, Carsten, Kolho, Kaija-Leena, Jakobsen, Christian, Cohen, Shlomi, Shouval, Dror S, de Meij, Tim, Martin-de-Carpi, Javier, Richmond, Lisa, Bronsky, Jiri, Friedman, Mira, and Turner, Dan

Published
2017
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24. Children included in randomised controlled trials of biologics in inflammatory bowel diseases do not represent the real‐world patient mix

Author

Atia, Ohad, primary, Pujol‐Muncunill, Gemma, additional, Navas‐López, Víctor Manuel, additional, Orlanski‐Meyer, Esther, additional, Ledder, Oren, additional, Lev‐Tzion, Raffi, additional, Focht, Gili, additional, Shteyer, Eyal, additional, Stein, Ronen, additional, Aloi, Marina, additional, Russell, Richard K., additional, Martin‐de‐Carpi, Javier, additional, and Turner, Dan, additional

Published
2022
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27. An ESPGHAN Position Paper on the Use of Breath Testing in Paediatric Gastroenterology

Author

Broekaert, Ilse Julia, primary, Borrelli, Osvaldo, additional, Dolinsek, Jernej, additional, Martin-de-Carpi, Javier, additional, Mas, Emmanuel, additional, Miele, Erasmo, additional, Pienar, Corina, additional, Ribes-Koninckx, Carmen, additional, Thomassen, Rut, additional, Thomson, Mike, additional, Tzivinikos, Christos, additional, and Benninga, Marc, additional

Published
2021
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28. Systematic review and meta‐analysis: the incidence and prevalence of paediatric coeliac disease across Europe

Author

Roberts, Stephen E., primary, Morrison‐Rees, Sian, additional, Thapar, Nikhil, additional, Benninga, Marc A., additional, Borrelli, Osvaldo, additional, Broekaert, Ilse, additional, Dolinsek, Jernej, additional, Martin‐de‐Carpi, Javier, additional, Mas, Emmanuel, additional, Miele, Erasmo, additional, Pienar, Corina, additional, Ribes‐Koninckx, Carmen, additional, Thomassen, Rut A., additional, Thomson, Mike, additional, Tzivinikos, Christos, additional, Thorne, Kymberley, additional, John, Ann, additional, and Williams, John G., additional

Published
2021
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30. 41 - BENEFICIO DE LOS PROGRAMAS DE TRANSICIÓN EN ENFERMEDAD INFLAMATORIA INTESTINAL: ESTUDIO BUTTERFLY DE GETECCU Y SEGHNP

Author

de Célix, Cristina Rubín, Martín-de-Carpi, Javier, Pujol-Muncunill, Gemma, Palomino, Laura María, Rodríguez-Belvís, Marta Velasco, Martín-Masot, Rafael, Navas-López, Víctor Manuel, Ricart, Elena, Casanova, María José, Martínez, Alejandro Rodríguez, Leo-Carnerero, Eduardo, Alcaraz, Alba, Mañosa, Miriam, Hernández, Vicent, Cobelas, María Consuelo Cobelas, Sánchez, César, Menchén, Luis, Mesonero, Francisco, Acosta, Manuel Barreiro-De, Martínon, Nazareth, Sandoval, Coral Tejido, Vázquez, Alicia Rendo, Corsino, Pilar, Vicente, Raquel, Hernández-Camba, Alejandro, Alonso, José Ramón Alberto, Alonso-Abreu, I., Millán, Ana María Castro, Reverter, Laia Peries, Castro, Beatriz, Fernández-Salgado, Estela, Cuiñas, M Mercedes Busto, Benítez, José Manuel, Madero, Lucía, Clemente, Fernando, Riestra, Sabino, Treviño, Santiago Jiménez, Boscá-Watts, Maia, Crehuá-Gaudiza, Elena, Moya, Marta Calvo, Huguet, José María, Largo-Blanco, Ester-María, Vives, Leticia González, Plaza, Rocío, Guerra, Iván, Barrio, Josefa, Escartín, Laura, Alfambra, Erika, Cruz, Noelia, Muñoz, M Carmen, Pino, María Guadalupe Muñoz, Van Domselaar, Manuel, Botella, Belén, Miquel, David Monfort, Grau, M Carmen Rodríguez, De La Mano, Agustín, Ber, Yolanda, Iñiguez, María Calvo, de Jesús Martínez-Pérez, Teresa, Chaparro, María, and Gisbert, Javier P.

Published
2023
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32. Corrigendum : Vedolizumab in paediatric inflammatory Bowel Disease: A retrospective multi-centre experience from the paediatric IBD Porto Group of ESPGHAN

Author

Ledder, Oren, Assa, Amit, Levine, Arie, Escher, Johanna C., de Ridder, Lissy, Ruemmele, Frank, Shah, Neil, Shaoul, Ron, Wolters, Victorien M., Rodrigues, Astor, Uhlig, Holm H., Posovszky, Carsten, Kolho, Kaija Leena, Jakobsen, Christian, Cohen, Shlomi, Shouval, Dror S., de Meij, Tim, Martin-de-Carpi, Javier, Richmond, Lisa, Bronsky, Jiri, Friedman, Mira, and Turner, Dan

Subjects
Gastroenterology
Abstract

In the original article, author Carsten Posovszky's surname was incorrectly spelt. This has now been corrected.

Published
2018

33. Complicated Disease and Response to Initial Therapy Predicts Early Surgery in Paediatric Crohn’s Disease: Results From the Porto Group GROWTH Study

Author

Levine, Arie, primary, Chanchlani, Neil, additional, Hussey, Seamus, additional, Ziv-Baran, Tomer, additional, Escher, Johanna C, additional, Amil Dias, Jorge, additional, Veres, Gabor, additional, Koletzko, Sibylle, additional, Turner, Dan, additional, Kolho, Kaija-Leena, additional, Paerregaard, Anders, additional, Staiano, Annamaria, additional, Lionetti, Paolo, additional, Nuti, Federica, additional, Sladek, Malgorata, additional, Shaoul, Ron, additional, Lazowska-Prezeorek, Isabella, additional, Martin de Carpi, Javier, additional, Sigall Boneh, Rotem, additional, Pfeffer Gik, Tamar, additional, Cohen-Dolev, Noa, additional, and Russell, Richard K, additional

Published
2019
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34. Designing clinical trials in paediatric inflammatory bowel diseases: a PIBDnet commentary

Author

Turner, Dan, primary, Griffiths, Anne M, additional, Wilson, David, additional, Mould, Diane R, additional, Baldassano, Robert N, additional, Russell, Richard K, additional, Dubinsky, Marla, additional, Heyman, Melvin B, additional, de Ridder, Lissy, additional, Hyams, Jeffrey, additional, Martin de Carpi, Javier, additional, Conklin, Laurie, additional, Faubion, William A, additional, Koletzko, Sibylle, additional, Bousvaros, Athos, additional, and Ruemmele, Frank M, additional

Published
2019
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35. Response to treatment is more important than disease severity at diagnosis for prediction of early relapse in new-onset paediatric Crohn’s disease

Author

Ziv-Baran, Tomer, primary, Hussey, Séamus, additional, Sladek, Malgorzata, additional, Amil Dias, Jorge, additional, Martin de Carpi, Javier, additional, Miele, Erasmo, additional, Veres, Gabor, additional, Lionetti, Paolo, additional, Koletzko, Sibylle, additional, Nuti, Federica, additional, Paerregaard, Anders, additional, Kolho, Kaija-Leena, additional, Russell, Richard K., additional, Shaoul, Ron, additional, Weiner, Dror, additional, Sigall Boneh, Rotem, additional, Escher, Johanna, additional, Finnby, Lenne, additional, Turner, Dan, additional, and Levine, Arie, additional

Published
2018
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36. Surgical Management of Crohn Disease in Children

Author

Amil-Dias, Jorge, Kolacek, Sanja, Turner, Dan, Pærregaard, Anders, Rintala, Risto, Afzal, Nadeem A., Karolewska-Bochenek, Katarzyna, Bronsky, Jiri, Chong, Sonny, Fell, John, Hojsak, Iva, Hugot, Jean-Pierre, Koletzko, Sibylle, Kumar, Devinder, Lazowska-Przeorek, Izabella, Lillehei, Craig, Lionetti, Paolo, Martin-de-Carpi, Javier, Pakarinen, Mikko, Ruemmele, Frank M., Shaoul, Ron, Spray, Christine, Staiano, Annamaria, Sugarman, Ian, Wilson, David C., Winter, Harland, and Kolho, Kaija-Leena

Subjects
ibd, digestive system diseases
Abstract

Surgical Management of Crohn Disease in Children

Published
2017

37. Efectividad y seguridad en nuestro entorno de adalimumab como tratamiento anti-TNF de primera linea en niños con enfermedad de Crohn

Author

Navas-López, Víctor Manuel, Pujol Muncunill, Gemma, Llerena, Enrique, Navalón Rubio, María, Gil-Ortega, David, Varea-Calderón, Vicente, Sierra Salinas, Carlos, and Martin-de-Carpi, Javier

Abstract

Adalimumab (ADA), anticuerpo anti-TNF-α monoclonal recombinante de origen humano, generalmente se emplea como tratamiento de segunda línea en niños con enfermedad de Crohn (EC) que no han respondido o han perdido respuesta a infliximab (IFX). En las series publicadas más del 70% de los pacientes habían sido tratados inicialmente con IFX. Los datos sobre la eficacia a corto y a largo plazo de ADA en pacientes naïvea anti-TNF son muy limitados. El objetivo del presente estudio es describir nuestra experiencia con ADA como tratamiento anti-TNF de primera línea en niños con EC.

Published
2024
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39. Surgical Management of Crohn Disease in Children: Guidelines From the Paediatric IBD Porto Group of ESPGHAN

Author

Amil-Dias, Jorge, primary, Kolacek, Sanja, additional, Turner, Dan, additional, Pærregaard, Anders, additional, Rintala, Risto, additional, Afzal, Nadeem A., additional, Karolewska-Bochenek, Katarzyna, additional, Bronsky, Jiri, additional, Chong, Sonny, additional, Fell, John, additional, Hojsak, Iva, additional, Hugot, Jean-Pierre, additional, Koletzko, Sibylle, additional, Kumar, Devinder, additional, Lazowska-Przeorek, Izabella, additional, Lillehei, Craig, additional, Lionetti, Paolo, additional, Martin-de-Carpi, Javier, additional, Pakarinen, Mikko, additional, Ruemmele, Frank M., additional, Shaoul, Ron, additional, Spray, Christine, additional, Staiano, Annamaria, additional, Sugarman, Ian, additional, Wilson, David C., additional, Winter, Harland, additional, and Kolho, Kaija-Leena, additional

Published
2017
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40. Differences in Outcomes Over Time With Exclusive Enteral Nutrition Compared With Steroids in Children With Mild to Moderate Crohn’s Disease: Results From theGROWTH CDStudy

Author

Cohen-Dolev, Noa, primary, Sladek, Malgorata, additional, Hussey, Seamus, additional, Turner, Dan, additional, Veres, Gabor, additional, Koletzko, Sibylle, additional, Martin de Carpi, Javier, additional, Staiano, Annamaria, additional, Shaoul, Ron, additional, Lionetti, Paolo, additional, Amil Dias, Jorge, additional, Paerregaard, Anders, additional, Nuti, Federica, additional, Pfeffer Gik, Tamar, additional, Ziv-Baran, Tomer, additional, Ben Avraham Shulman, Sivan, additional, Sarbagili Shabat, Chen, additional, Sigall Boneh, Rotem, additional, Russell, Richard K, additional, and Levine, Arie, additional

Published
2017
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41. Designing clinical trials in paediatric inflammatory bowel diseases: a PIBDnet commentary

Author

Turner, Dan, Griffiths, Anne M, Wilson, David, Mould, Diane R, Baldassano, Robert N, Russell, Richard K, Dubinsky, Marla, Heyman, Melvin B, de Ridder, Lissy, Hyams, Jeffrey, Martin de Carpi, Javier, Conklin, Laurie, Faubion, William A, Koletzko, Sibylle, Bousvaros, Athos, and Ruemmele, Frank M

Abstract

IntroductionThe optimal trial design for assessing novel therapies in paediatric IBD (PIBD) is a subject of intense ongoing global discussions and debate among the different stakeholders. However, there is a consensus that the current situation in which most medications used in children with IBD are prescribed as off-label without sufficient paediatric data is unacceptable. Shortening the time lag between adult and paediatric approval of drugs is of the upmost importance. In this position paper we aimed to provide guidance from the global clinical research network (Pediatric Inflammatory Bowel Disease Network, PIBDnet) for designing clinical trials in PIBD in order to facilitate drug approval for children.MethodsA writing group has been established by PIBDnet and topics were assigned to different members. After an iterative process of revisions among the writing group and one face-to-face meeting, all statements have reached consensus of >80% as defined a priori. Next, all core members of PIBDnet voted on the statements, reaching consensus of >80% on all statements. Comments from the members were incorporated in the text.ResultsThe commentary includes 18 statements for guiding data extrapolation from adults, eligibility criteria to PIBD trials, use of placebo, dosing, endpoints and recommendations for feasible trials. Controversial issues have been highlighted in the text.ConclusionThe viewpoints expressed in this paper could assist planning clinical trials in PIBD which are both of high quality and ethical, while remaining pragmatic.

Published
2020
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42. ESPGHAN Revised Porto Criteria for the Diagnosis of Inflammatory Bowel Disease in Children and Adolescents

Author

Levine, Arie, primary, Koletzko, Sibylle, additional, Turner, Dan, additional, Escher, Johanna C., additional, Cucchiara, Salvatore, additional, de Ridder, Lissy, additional, Kolho, Kaija-Leena, additional, Veres, Gabor, additional, Russell, Richard K., additional, Paerregaard, Anders, additional, Buderus, Stephan, additional, Greer, Mary-Louise C., additional, Dias, Jorge A., additional, Veereman-Wauters, Gigi, additional, Lionetti, Paolo, additional, Sladek, Malgorzata, additional, Martin de Carpi, Javier, additional, Staiano, Annamaria, additional, Ruemmele, Frank M., additional, and Wilson, David C., additional

Published
2014
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43. Malignancy and Mortality in Pediatric Patients with Inflammatory Bowel Disease

Author

de Ridder, Lissy, primary, Turner, Dan, additional, Wilson, David C., additional, Koletzko, Sibylle, additional, Martin-de-Carpi, Javier, additional, Fagerberg, Ulrika L., additional, Spray, Christine, additional, Sladek, Malgorzata, additional, Shaoul, Ron, additional, Roma-Giannikou, Eleftheria, additional, Bronsky, Jiri, additional, Serban, Daniela E., additional, Cucchiara, Salvatore, additional, Veres, Gabor, additional, Ruemmele, Frank M., additional, Hojsak, Iva, additional, Kolho, Kaija L., additional, Davies, Ieuan H., additional, Aloi, Marina, additional, Lionetti, Paolo, additional, Veereman-Wauters, Gigi, additional, Braegger, Christian P., additional, Trindade, Eunice, additional, Wewer, Anne V., additional, Hauer, Almuthe, additional, and Levine, Arie, additional

Published
2014
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44. Comparison of Outcomes Parameters for Induction of Remission in New Onset Pediatric Crohnʼs Disease

Author

Levine, Arie, primary, Turner, Dan, additional, Pfeffer Gik, Tamar, additional, Amil Dias, Jorge, additional, Veres, Gabor, additional, Shaoul, Ron, additional, Staiano, Annamaria, additional, Escher, Johanna, additional, Kolho, Kaija Leena, additional, Paerregaard, Anders, additional, Martin de Carpi, Javier, additional, Veereman Wauters, Gigi, additional, Koletzko, Sibylle, additional, Shevah, Orit, additional, Finnby, Lenne, additional, and Sladek, Malgorzata, additional

Published
2014
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48. Helicobacter pylori-negative Chronic Gastritis in Children

Author

Amit Assa, Osvaldo Borrelli, Ilse Broekaert, Marco Deganello Saccomani, Jernej Dolinsek, Javier Martin-de-Carpi, Emmanuel Mas, Erasmo Miele, Sara Sila, Mike Thomson, Christos Tzivinikos, Marc A. Benninga, Pediatric surgery, Paediatric Gastroenterology, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam Reproduction & Development (AR&D), Assa, Amit, Borrelli, Osvaldo, Broekaert, Ilse, Saccomani, Marco Deganello, Dolinsek, Jernej, Martin-de-Carpi, Javier, Mas, Emmanuel, Miele, Erasmo, Sila, Sara, Thomson, Mike, Tzivinikos, Christo, and Benninga, Marc A

Subjects
Adult, Cross-Sectional Studies, Helicobacter pylori, Gastritis, Pediatrics, Perinatology and Child Health, Eosinophilia, Gastroenterology, Humans, Child, Enteritis, Helicobacter Infections
Abstract

OBJECTIVES: To systematically review the current evidence on Helicobacter pylori-negative chronic gastritis including natural history, available therapies and outcomes. METHODS: Articles providing data on the prevalence, treatment or outcomes of Helicobacter pylori-negative gastritis were identified through a systematic search in the MEDLINE and EMBASE databases. All original research articles from human studies until October 31, 2021, were included. RESULTS: A total of 54 studies were included consisted of eosinophilic gastritis (n = 9), autoimmune gastritis (n = 11), collagenous gastritis (n = 16), focally enhanced gastritis (n = 6), lymphocytic gastritis (n = 5) and other causes including idiopathic gastritis and chronic renal failure related (n = 7). Most of the included studies were either cross-sectional or longitudinal cohorts except for collagenous gastritis, which mainly included case reports and case series. The prevalence of paediatric eosinophilic gastritis ranges between 5 and 7/100,000 and patients have generally favourable outcome with 50% to 70% clinical and histological response to either corticosteroids or elimination diets. Autoimmune gastritis and collagenous gastritis are extremely rare entities, commonly present with refractory iron deficiency anaemia, while lymphocytic gastritis is relatively common (10%-45%) in children with coeliac disease. Data on treatments and outcomes of autoimmune, collagenous, and focally enhanced gastritis are lacking with limited data implying poor response to therapy in the former 2 diagnoses. CONCLUSIONS: Helicobacter pylori-negative gastritis is uncommonly reported, mainly in small cohorts, mixed adult-paediatric cohorts or as sporadic case reports. As common symptoms are not specific, thus not always result in an endoscopic evaluation, the true prevalence of these distinct disorders may be underestimated, and thus under reported.

Published
2022

49. Systematic review and meta‐analysis: the incidence and prevalence of paediatric coeliac disease across Europe

Author

Osvaldo Borrelli, Christos Tzivinikos, Corina Pienar, Carmen Ribes-Koninckx, John Williams, Kym Thorne, Ilse Broekaert, Stephen E. Roberts, Javier Martín-de-Carpi, Ann John, Emmanuel Mas, Nikhil Thapar, Marc A. Benninga, Rut Anne Thomassen, Mike Thomson, Jernej Dolinsek, Sian Morrison-Rees, Erasmo Miele, Roberts, Stephen E, Morrison-Rees, Sian, Thapar, Nikhil, Benninga, Marc A, Borrelli, Osvaldo, Broekaert, Ilse, Dolinsek, Jernej, Martin-de-Carpi, Javier, Mas, Emmanuel, Miele, Erasmo, Pienar, Corina, Ribes-Koninckx, Carmen, Thomassen, Rut A, Thomson, Mike, Tzivinikos, Christo, Thorne, Kymberley, John, Ann, Williams, John G, Swansea University, Great Ormond Street Hospital for Children [London] (GOSH), University College of London [London] (UCL), Children’s Health Queensland [Brisbane] (CHQ), University of Amsterdam [Amsterdam] (UvA), University Hospital of Cologne [Cologne], University medical centre Maribor (UKC Maribor), Institut de Recerca Pediàtrica Hospital Sant Joan de Déu [Barcelona, Spain], Institut de Recherche en Santé Digestive (IRSD ), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), 'Federico II' University of Naples Medical School, Victor Babeş University of Medicine and Pharmacy (UMFT), Hospital Universitari i Politècnic La Fe, Oslo University Hospital [Oslo], University of Sheffield [Sheffield], Al Jalila Children's Specialty Hospital, and European Society for Paediatric Gastroenterology Hepatology and Nutrition

Subjects
Pediatrics, medicine.medical_specialty, MEDLINE, Age at diagnosis, Cochrane Library, Asymptomatic, Coeliac disease, Serology, 03 medical and health sciences, 0302 clinical medicine, 030225 pediatrics, Prevalence, medicine, Humans, Pharmacology (medical), Child, Aged, Autoantibodies, [SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics, Hepatology, business.industry, Incidence, Incidence (epidemiology), Gastroenterology, Infant, medicine.disease, 3. Good health, Europe, Celiac Disease, Child, Preschool, Meta-analysis, 030211 gastroenterology & hepatology, medicine.symptom, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

Background: Coeliac disease is one of the most prevalent immune-mediated gastrointestinal disorders in children. Aim: To review the incidence and prevalence of paediatric coeliac disease, and their trends, regionally across Europe, overall and according to age at diagnosis. Methods: Systematic review and meta-analysis from January 1, 1950 to December 31, 2019, based on PubMed, CINAHL and the Cochrane Library, searches of grey literature and websites and hand searching of reference lists. A total of 127 eligible studies were included. Results: The prevalence of previously undiagnosed coeliac disease from screening surveys (histology based) ranged from 0.10% to 3.03% (median = 0.70%), with a significantly increasing annual trend (P = 0.029). Prevalence since 2000 was significantly higher in northern Europe (1.60%) than in eastern (0.98%), southern (0.69%) and western (0.60%) Europe. Large increases in the incidence of diagnosed coeliac disease across Europe have reached 50 per 100 000 person-years in Scandinavia, Finland and Spain. The median age at diagnosis increased from 1.9 years before 1990 to 7.6 since 2000. Larger increases in incidence were found in older age groups than in infants and ages

Published
2021

50. An ESPGHAN Position Paper on the Use of Breath Testing in Paediatric Gastroenterology

Author

Rut Ann Thomassen, Jernej Dolinsek, Carmen Ribes-Koninckx, Erasmo Miele, Christos Tzivinikos, Corina Pienar, Javier Martín-de-Carpi, Emmanuel Mas, Marc A. Benninga, Osvaldo Borrelli, Ilse Broekaert, Mike Thomson, University Hospital of Cologne [Cologne], Great Ormond Street Hospital for Children [London] (GOSH), University medical centre Maribor (UKC Maribor), Hospital Sant Joan de Déu [Barcelona], Institut de Recherche en Santé Digestive (IRSD ), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), 'Federico II' University of Naples Medical School, Victor Babeş University of Medicine and Pharmacy (UMFT), Hospital Universitari i Politècnic La Fe = University and Polytechnic Hospital La Fe, Oslo University Hospital [Oslo], Sheffield Children's NHS Foundation Trust, Al Jalila Children's Specialty Hospital, VU University Medical Center [Amsterdam], SEGUIN, Nathalie, Broekaert, Ilse Julia, Borrelli, Osvaldo, Dolinsek, Jernej, Martin-de-Carpi, Javier, Mas, Emmanuel, Miele, Erasmo, Pienar, Corina, Ribes-Koninckx, Carmen, Thomassen, Rut, Thomson, Mike, Tzivinikos, Christo, Benninga, Marc, and Hospital Universitari i Politècnic La Fe

Subjects
medicine.medical_specialty, Malabsorption, Consensus, Carbohydrate malabsorption, 030309 nutrition & dietetics, MEDLINE, carbohydrate malabsorption, small intestinal bacterial overgrowth, Helicobacter pylori infection, Helicobacter Infections, 03 medical and health sciences, 0302 clinical medicine, [SDV.MHEP.PED] Life Sciences [q-bio]/Human health and pathology/Pediatrics, children, Internal medicine, Small intestinal bacterial overgrowth, medicine, breath testing, Humans, Intensive care medicine, Exocrine pancreatic insufficiency, Child, Children, 0303 health sciences, [SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, business.industry, Gastroenterology, [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, Hepatology, medicine.disease, [SDV.MHEP.HEG] Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, 3. Good health, Fat malabsorption, Breath testing, Systematic review, Breath Tests, Pediatrics, Perinatology and Child Health, Position paper, 030211 gastroenterology & hepatology, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Systematic Reviews as Topic
Abstract

International audience; Objectives: Given a lack of a systematic approach to the use of breath testing in paediatric patients, the aim of this position paper is to provide expert guidance regarding the indications for its use and practical considerations to optimise its utility and safety. Methods: Nine clinical questions regarding methodology, interpretation, and specific indications of breath testing and treatment of carbohydrate malabsorption were addressed by members of the Gastroenterology Committee (GIC) of the European Society for Paediatric Gastroenterology Hepatology and Nutrition (ESPGHAN). A systematic literature search was performed from 1983 to 2020 using PubMed, the MEDLINE and Cochrane Database of Systematic Reviews. Grading of Recommendations, Assessment, Development, and Evaluation was applied to evaluate the outcomes. During a consensus meeting, all recommendations were discussed and finalised. In the absence of evidence from randomised controlled trials, recommendations reflect the expert opinion of the authors. Results: A total of 22 recommendations were voted on using the nominal voting technique. At first, recommendations on prerequisites and preparation for as well as on interpretation of breath tests are given. Then, recommendations on the usefulness of H2-lactose breath testing, H2-fructose breath testing as well as of breath tests for other types of carbohydrate malabsorption are provided. Furthermore, breath testing is recommended to diagnose small intestinal bacterial overgrowth (SIBO), to control for success of Helicobacter pylori eradication therapy and to diagnose and monitor therapy of exocrine pancreatic insufficiency, but not to estimate oro-caecal transit time (OCTT) or to diagnose and follow-up on celiac disease. Conclusions: Breath tests are frequently used in paediatric gastroenterology mainly assessing carbohydrate malabsorption, but also in the diagnosis of small intestinal overgrowth, fat malabsorption, H. pylori infection as well as for measuring gastrointestinal transit times. Interpretation of the results can be challenging and in addition, pertinent symptoms should be considered to evaluate clinical tolerance.

Published
2021

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