6 results on '"Martin-Lamb D"'
Search Results
2. Feasibility of non-invasive neuro-monitoring during extracorporeal membrane oxygenation in children.
- Author
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McDevitt WM, Farley M, Martin-Lamb D, Jones TJ, Morris KP, Seri S, and Scholefield BR
- Subjects
- Humans, Male, Child, Infant, Female, Prospective Studies, Feasibility Studies, Spectroscopy, Near-Infrared methods, Catheterization, Retrospective Studies, Extracorporeal Membrane Oxygenation adverse effects, Extracorporeal Membrane Oxygenation methods
- Abstract
Introduction: Detection of neurological complications during extracorporeal membrane oxygenation (ECMO) may be enhanced with non-invasive neuro-monitoring. We investigated the feasibility of non-invasive neuro-monitoring in a paediatric intensive care (PIC) setting., Methods: In a single centre, prospective cohort study we assessed feasibility of recruitment, and neuro-monitoring via somatosensory evoked potentials (SSEP), electroencephalography (EEG) and near infrared spectroscopy (NIRS) during venoarterial (VA) ECMO in paediatric patients (0-15 years). Measures were obtained within 24h of cannulation, during an intermediate period, and finally at decannulation or echo stress testing. SSEP/EEG/NIRS measures were correlated with neuro-radiology findings, and clinical outcome assessed via the Pediatric cerebral performance category (PCPC) scale 30 days post ECMO cannulation., Results: We recruited 14/20 (70%) eligible patients (median age: 9 months; IQR:4-54, 57% male) over an 18-month period, resulting in a total of 42 possible SSEP/EEG/NIRS measurements. Of these, 32/42 (76%) were completed. Missed recordings were due to lack of access/consent within 24 h of cannulation (5/42, 12%) or PIC death/discharge (5/42, 12%). In each patient, the majority of SSEP (8/14, 57%), EEG (8/14, 57%) and NIRS (11/14, 79%) test results were within normal limits. All patients with abnormal neuroradiology (4/10, 40%), and 6/7 (86%) with poor outcome (PCPC ≥4) developed indirect SSEP, EEG or NIRS measures of neurological complications prior to decannulation. No study-related adverse events or neuro-monitoring data interpreting issues were experienced., Conclusion: Non-invasive neuro-monitoring (SSEP/EEG/NIRS) during ECMO is feasible and may provide early indication of neurological complications in this high-risk population.
- Published
- 2023
- Full Text
- View/download PDF
3. Pediatric stereo-electroencephalography: effects of robot assistance and other variables on seizure outcome and complications.
- Author
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Mavridis IN, Lo WB, Wimalachandra WSB, Philip S, Agrawal S, Scott C, Martin-Lamb D, Carr B, Bill P, Lawley A, Seri S, and Walsh AR
- Subjects
- Adolescent, Child, Child, Preschool, Drug Resistant Epilepsy diagnostic imaging, Electrodes, Implanted, Female, Humans, Kaplan-Meier Estimate, Male, Neurosurgical Procedures adverse effects, Postoperative Complications epidemiology, Postoperative Complications surgery, Retrospective Studies, Robotic Surgical Procedures adverse effects, Seizures diagnostic imaging, Stereotaxic Techniques, Survival Analysis, Tomography, X-Ray Computed, Treatment Outcome, Drug Resistant Epilepsy surgery, Electroencephalography methods, Neurosurgical Procedures instrumentation, Neurosurgical Procedures methods, Robotic Surgical Procedures instrumentation, Robotic Surgical Procedures methods, Seizures surgery
- Abstract
Objective: The safety of stereo-electroencephalography (SEEG) has been investigated; however, most studies have not differentiated pediatric and adult populations, which have different anatomy and physiology. The purpose of this study was to assess SEEG safety in the pediatric setting, focusing on surgical complications and the identification of patient and surgical risk factors, if any. The authors also aimed to determine whether robot assistance in SEEG was associated with a change in practice, surgical parameters, and clinical outcomes., Methods: The authors retrospectively studied all SEEG cases performed in their department from December 2014 to March 2020. They analyzed both demographic and surgical variables and noted the types of surgery-related complications and their management. They also studied the clinical outcomes of a subset of the patients in relation to robot-assisted and non-robot-assisted SEEG., Results: Sixty-three children had undergone 64 SEEG procedures. Girls were on average 3 years younger than the boys (mean age 11.1 vs 14.1 years, p < 0.01). The overall complication rate was 6.3%, and the complication rate for patients with left-sided electrodes was higher than that for patients with right-sided electrodes (11.1% vs 3.3%), although the difference between the two groups was not statistically significant. The duration of recording was positively correlated to the number of implanted electrodes (r = 0.296, p < 0.05). Robot assistance was associated with a higher number of implanted electrodes (mean 12.6 vs 7.6 electrodes, p < 0.0001). Robot-assisted implantations were more accurate, with a mean error of 1.51 mm at the target compared to 2.98 mm in nonrobot implantations (p < 0.001). Clinical outcomes were assessed in the first 32 patients treated (16 in the nonrobot group and 16 in the robot group), 23 of whom proceeded to further resective surgery. The children who had undergone robot-assisted SEEG had better eventual seizure control following subsequent epilepsy surgery. Of the children who had undergone resective epilepsy surgery, 42% (5/12) in the nonrobot group and 82% (9/11) in the robot group obtained an Engel class IA outcome at 1 year (χ2 = 3.885, p = 0.049). Based on Kaplan-Meier survival analysis, the robot group had a higher seizure-free rate than the nonrobot group at 30 months postoperation (7/11 vs 2/12, p = 0.063). Two complications, whose causes were attributed to the implantation and head-bandaging steps, required surgical intervention. All complications were either transient or reversible., Conclusions: This is the largest single-center, exclusively pediatric SEEG series that includes robot assistance so far. SEEG complications are uncommon and usually transient or treatable. Robot assistance enabled implantation of more electrodes and improved epilepsy surgery outcomes, as compared to those in the non-robot-assisted cases.
- Published
- 2021
- Full Text
- View/download PDF
4. Effects of low frequency filtering on distal compound muscle action potential duration for diagnosis of CIDP: A Japanese-European multicenter prospective study.
- Author
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Mitsuma S, Van den Bergh P, Rajabally YA, Van Parijs V, Martin-Lamb D, Sonoo M, Inaba A, Shimizu T, Isose S, Sato Y, Komori T, Misawa S, and Kuwabara S
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Child, Europe epidemiology, Female, Humans, Japan epidemiology, Male, Middle Aged, Neural Conduction physiology, Prospective Studies, Young Adult, Action Potentials physiology, Electromyography methods, Internationality, Polyradiculoneuropathy, Chronic Inflammatory Demyelinating diagnosis, Polyradiculoneuropathy, Chronic Inflammatory Demyelinating physiopathology
- Abstract
Objective: The duration of the distal compound muscle action potential (DCMAP) is a useful index to detect demyelination in the distal nerve segments. However in published electrodiagnostic criteria for chronic inflammatory demyelinating polyneuropathy (CIDP), the cut-off values of DCMAP duration are defined using an EMG low frequency filter of only 20 Hz. We aimed to provide widely-available reference data using several low cut filters., Methods: In 13 Japanese and European tertiary centers, DCMAP duration data using 2, 5, 10, and 20 Hz low frequency filters were prospectively collected from 147 normal controls, 59 patients with typical CIDP, and 100 with diabetic polyneuropathy. Optimal cut-off values were calculated with receiver-operating characteristic curves, offering 100% specificity versus normal controls., Results: The higher low frequency filter was associated with significantly shorter DCMAP duration in all groups. For CIDP diagnosis, the calculated cut-off values had a sensitivity ranging from 51% to 66%, and a specificity versus diabetic neuropathy from 96% to 98%., Conclusions: Our results show that DCMAP duration is largely dependent on low frequency filter settings, but is a useful index for CIDP diagnosis when the cut-off values are properly determined at each filter setting., Significance: Our data provide the systematic reference values of DCMAP duration for CIDP diagnosis available for most EMG laboratories., (Copyright © 2014 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.)
- Published
- 2015
- Full Text
- View/download PDF
5. Diagnostic value of MR imaging in the Lewis-Sumner syndrome: a case series.
- Author
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Rajabally YA, Knopp MJ, Martin-Lamb D, and Morlese J
- Subjects
- Adult, Aged, Female, Humans, Hypertrophy pathology, Male, Middle Aged, Neuroimaging, Polyradiculoneuropathy, Chronic Inflammatory Demyelinating pathology, Predictive Value of Tests, Syndrome, Brachial Plexus pathology, Cervical Cord pathology, Magnetic Resonance Imaging, Polyradiculoneuropathy, Chronic Inflammatory Demyelinating diagnosis
- Abstract
Lewis-Sumner syndrome (LSS) is considered a variant of chronic inflammatory demyelinating polyneuropathy (CIDP), which is more frequently described with exclusive upper limb involvement. The diagnosis of LSS is clinical and electrophysiological. However, these are not always obvious and in view of its rarity, the diagnosis may be missed and patients denied effective immunomodulatory therapy. We herein describe the magnetic resonance imaging (MRI) findings in a series of five consecutive patients with a clinical diagnosis of LSS, using T2 STIR (Short Tau Inversion recovery) images without contrast. We demonstrated hyperintensity with or without hypertrophy of cervical roots and/or brachial plexus on the affected side and/or controlaterally which aided diagnostic confirmation. This helped therapeutic decision making regarding immunotherapy in all cases. MR imaging of the cervical spine/brachial plexus with T2 STIR may be helpful in suspected cases of LSS as it represents a very useful additional diagnostic tool., (Copyright © 2014 Elsevier B.V. All rights reserved.)
- Published
- 2014
- Full Text
- View/download PDF
6. Compound muscle action potential amplitude and distal potential duration in axonal neuropathy.
- Author
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Rajabally YA, Martin-Lamb D, and Nicolas G
- Subjects
- Aged, Demyelinating Diseases diagnosis, Demyelinating Diseases physiopathology, Diagnosis, Differential, Female, Humans, Male, Motor Neurons physiology, Neural Conduction physiology, Peroneal Nerve physiopathology, Retrospective Studies, Tibial Nerve physiopathology, Time Factors, Action Potentials physiology, Muscle, Skeletal innervation, Polyneuropathies diagnosis, Polyneuropathies physiopathology
- Published
- 2014
- Full Text
- View/download PDF
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