32 results on '"Martin-Chouly, Corinne"'
Search Results
2. Obesity III: Obesogen assays: Limitations, strengths, and new directions
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Kassotis, Christopher D, Vom Saal, Frederick S, Babin, Patrick J, Lagadic-Gossmann, Dominique, Le Mentec, Helene, Blumberg, Bruce, Mohajer, Nicole, Legrand, Antoine, Munic Kos, Vesna, Martin-Chouly, Corinne, Podechard, Normand, Langouët, Sophie, Touma, Charbel, Barouki, Robert, Kim, Min Ji, Audouze, Karine, Choudhury, Mahua, Shree, Nitya, Bansal, Amita, Howard, Sarah, and Heindel, Jerrold J
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Biochemistry and Cell Biology ,Biomedical and Clinical Sciences ,Biological Sciences ,Obesity ,Generic health relevance ,3T3-L1 Cells ,Adipocytes ,Adipogenesis ,Animals ,Caenorhabditis elegans ,Cell Differentiation ,Mice ,Zebrafish ,Mesenchymal stem cells ,3T3-L1 ,Pharmacology and Pharmaceutical Sciences ,Pharmacology & Pharmacy ,Biochemistry and cell biology ,Pharmacology and pharmaceutical sciences - Abstract
There is increasing evidence of a role for environmental contaminants in disrupting metabolic health in both humans and animals. Despite a growing need for well-understood models for evaluating adipogenic and potential obesogenic contaminants, there has been a reliance on decades-old in vitro models that have not been appropriately managed by cell line providers. There has been a quick rise in available in vitro models in the last ten years, including commercial availability of human mesenchymal stem cell and preadipocyte models; these models require more comprehensive validation but demonstrate real promise in improved translation to human metabolic health. There is also progress in developing three-dimensional and co-culture techniques that allow for the interrogation of a more physiologically relevant state. While diverse rodent models exist for evaluating putative obesogenic and/or adipogenic chemicals in a physiologically relevant context, increasing capabilities have been identified for alternative model organisms such as Drosophila, C. elegans, zebrafish, and medaka in metabolic health testing. These models have several appreciable advantages, including most notably their size, rapid development, large brood sizes, and ease of high-resolution lipid accumulation imaging throughout the organisms. They are anticipated to expand the capabilities of metabolic health research, particularly when coupled with emerging obesogen evaluation techniques as described herein.
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- 2022
3. Obesity II: Establishing causal links between chemical exposures and obesity
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Heindel, Jerrold J, Howard, Sarah, Agay-Shay, Keren, Arrebola, Juan P, Audouze, Karine, Babin, Patrick J, Barouki, Robert, Bansal, Amita, Blanc, Etienne, Cave, Matthew C, Chatterjee, Saurabh, Chevalier, Nicolas, Choudhury, Mahua, Collier, David, Connolly, Lisa, Coumoul, Xavier, Garruti, Gabriella, Gilbertson, Michael, Hoepner, Lori A, Holloway, Alison C, Howell, George, Kassotis, Christopher D, Kay, Mathew K, Kim, Min Ji, Lagadic-Gossmann, Dominique, Langouet, Sophie, Legrand, Antoine, Li, Zhuorui, Le Mentec, Helene, Lind, Lars, Lind, P Monica, Lustig, Robert H, Martin-Chouly, Corinne, Kos, Vesna Munic, Podechard, Normand, Roepke, Troy A, Sargis, Robert M, Starling, Anne, Tomlinson, Craig R, Touma, Charbel, Vondracek, Jan, Saal, Frederick vom, and Blumberg, Bruce
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Genetics ,Nutrition ,Obesity ,Digestive Diseases ,Prevention ,Oral and gastrointestinal ,Metabolic and endocrine ,Adipogenesis ,Adipose Tissue ,Child ,Preschool ,Endocrine Disruptors ,Environmental Exposure ,Humans ,Obesogen ,Adipocyte differentiation ,Weight gain ,Endocrine disruptor ,Biochemistry and Cell Biology ,Pharmacology and Pharmaceutical Sciences ,Pharmacology & Pharmacy - Abstract
Obesity is a multifactorial disease with both genetic and environmental components. The prevailing view is that obesity results from an imbalance between energy intake and expenditure caused by overeating and insufficient exercise. We describe another environmental element that can alter the balance between energy intake and energy expenditure: obesogens. Obesogens are a subset of environmental chemicals that act as endocrine disruptors affecting metabolic endpoints. The obesogen hypothesis posits that exposure to endocrine disruptors and other chemicals can alter the development and function of the adipose tissue, liver, pancreas, gastrointestinal tract, and brain, thus changing the set point for control of metabolism. Obesogens can determine how much food is needed to maintain homeostasis and thereby increase the susceptibility to obesity. The most sensitive time for obesogen action is in utero and early childhood, in part via epigenetic programming that can be transmitted to future generations. This review explores the evidence supporting the obesogen hypothesis and highlights knowledge gaps that have prevented widespread acceptance as a contributor to the obesity pandemic. Critically, the obesogen hypothesis changes the narrative from curing obesity to preventing obesity.
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- 2022
4. Assessment of endocrine disruptor impacts on lipid metabolism in a fatty acid-supplemented HepaRG human hepatic cell line
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Bernal, Kévin, Touma, Charbel, Le-Grand, Béatrice, Rose, Sophie, Degerli, Selenay, Genêt, Valentine, Lagadic-Gossmann, Dominique, Coumoul, Xavier, Martin-Chouly, Corinne, Langouët, Sophie, and Blanc, Etienne B
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- 2024
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5. Obesity II: Establishing causal links between chemical exposures and obesity
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Heindel, Jerrold J., Howard, Sarah, Agay-Shay, Keren, Arrebola, Juan P., Audouze, Karine, Babin, Patrick J., Barouki, Robert, Bansal, Amita, Blanc, Etienne, Cave, Matthew C., Chatterjee, Saurabh, Chevalier, Nicolas, Choudhury, Mahua, Collier, David, Connolly, Lisa, Coumoul, Xavier, Garruti, Gabriella, Gilbertson, Michael, Hoepner, Lori A., Holloway, Alison C., Howell, George, III, Kassotis, Christopher D., Kay, Mathew K., Kim, Min Ji, Lagadic-Gossmann, Dominique, Langouet, Sophie, Legrand, Antoine, Li, Zhuorui, Le Mentec, Helene, Lind, Lars, Monica Lind, P., Lustig, Robert H., Martin-Chouly, Corinne, Munic Kos, Vesna, Podechard, Normand, Roepke, Troy A., Sargis, Robert M., Starling, Anne, Tomlinson, Craig R., Touma, Charbel, Vondracek, Jan, vom Saal, Frederick, and Blumberg, Bruce
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- 2022
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6. Obesity III: Obesogen assays: Limitations, strengths, and new directions
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Kassotis, Christopher D., vom Saal, Frederick S., Babin, Patrick J., Lagadic-Gossmann, Dominique, Le Mentec, Helene, Blumberg, Bruce, Mohajer, Nicole, Legrand, Antoine, Munic Kos, Vesna, Martin-Chouly, Corinne, Podechard, Normand, Langouët, Sophie, Touma, Charbel, Barouki, Robert, Kim, Min Ji, Audouze, Karine, Choudhury, Mahua, Shree, Nitya, Bansal, Amita, Howard, Sarah, and Heindel, Jerrold J.
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- 2022
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7. MEHP/ethanol co-exposure favors the death of steatotic hepatocytes, possibly through CYP4A and ADH involvement
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Tête, Arnaud, Gallais, Isabelle, Imran, Muhammad, Legoff, Louis, Martin-Chouly, Corinne, Sparfel, Lydie, Bescher, Maëlle, Sergent, Odile, Podechard, Normand, and Lagadic-Gossmann, Dominique
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- 2020
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8. Low interleukin-10 release after ex vivo stimulation of whole blood is associated with persistent organ dysfunction in sepsis: A prospective observational study
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Nesseler, Nicolas, Martin-Chouly, Corinne, Perrichet, Harmonie, Ross, James T., Rousseau, Chloé, Sinha, Pratik, Isslame, Sonia, Masseret, Elodie, Mallédant, Yannick, Launey, Yoann, and Seguin, Philippe
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- 2019
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9. Assessment of endocrine disruptor impacts on lipid metabolism in a fatty acid-supplemented HepaRG human hepatic cell line
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Bernal, Kévin, primary, Touma, Charbel, additional, Le-Grand, Béatrice, additional, Rose, Sophie, additional, Degerli, Selenay, additional, Genêt, Valentine, additional, Lagadic-Gossmann, Dominique, additional, Coumoul, Xavier, additional, Martin-Chouly, Corinne, additional, Langouët, Sophie, additional, and Blanc, Etienne, additional
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- 2023
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10. The impact of impaired macrophage functions in cystic fibrosis disease progression
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Lévêque, Manuella, Le Trionnaire, Sophie, Del Porto, Paola, and Martin-Chouly, Corinne
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- 2017
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11. MiR-146a is over-expressed and controls IL-6 production in cystic fibrosis macrophages
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Luly, Francesco R., Lévêque, Manuella, Licursi, Valerio, Cimino, Giuseppe, Martin-Chouly, Corinne, Théret, Nathalie, Negri, Rodolfo, Cavinato, Luca, Ascenzioni, Fiorentina, and Del Porto, Paola
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- 2019
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12. Combinatorial pathway disruption is a powerful approach to delineate metabolic impacts of endocrine disruptors
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Bernal, Kévin, primary, Touma, Charbel, additional, Erradhouani, Chedi, additional, Boronat‐Belda, Talía, additional, Gaillard, Lucas, additional, Al Kassir, Sara, additional, Le Mentec, Hélène, additional, Martin‐Chouly, Corinne, additional, Podechard, Normand, additional, Lagadic‐Gossmann, Dominique, additional, Langouet, Sophie, additional, Brion, François, additional, Knoll‐Gellida, Anja, additional, Babin, Patrick J., additional, Sovadinova, Iva, additional, Babica, Pavel, additional, Andreau, Karine, additional, Barouki, Robert, additional, Vondracek, Jan, additional, Alonso‐Magdalena, Paloma, additional, Blanc, Etienne, additional, Kim, Min Ji, additional, and Coumoul, Xavier, additional
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- 2022
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13. Corrigendum to “Obesity III: Obesogen assays: Limitations, strengths, and new directions” [Biochem. Pharmacol. 199 (2022) 115014]
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Kassotis, Christopher D., primary, vom Saal, Frederick S., additional, Babin, Patrick J., additional, Lagadic- Gossmann, Dominique, additional, Le Mentec, Helene, additional, Blumberg, Bruce, additional, Mohajer, Nicole, additional, Legrand, Antoine, additional, Munic Kos, Vesna, additional, Martin-Chouly, Corinne, additional, Podechard, Normand, additional, Langouët, Sophie, additional, Touma, Charbel, additional, Barouki, Robert, additional, Kim, Min Ji, additional, Audouze, Karine, additional, Choudhury, Mahua, additional, Shree, Nitya, additional, Bansal, Amita, additional, Howard, Sarah, additional, and Heindel, Jerrold J., additional
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- 2022
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14. Corrigendum to “Obesity II: Establishing causal links between chemical exposures and obesity” [Biochem. Pharmacol. 199 (2022) 115015]
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Heindel, Jerrold J., primary, Howard, Sarah, additional, Agay-Shay, Keren, additional, Arrebola, Juan P., additional, Audouze, Karine, additional, Babin, Patrick J., additional, Barouki, Robert, additional, Bansal, Amita, additional, Blanc, Etienne, additional, Cave, Matthew C., additional, Chatterjee, Saurabh, additional, Chevalier, Nicolas, additional, Choudhury, Mahua, additional, Collier, David, additional, Connolly, Lisa, additional, Coumoul, Xavier, additional, Garruti, Gabriella, additional, Gilbertson, Michael, additional, Hoepner, Lori A., additional, Holloway, Alison C., additional, Howell, George, additional, Kassotis, Christopher D., additional, Kay, Mathew K., additional, Kim, Min Ji, additional, Lagadic-Gossmann, Dominique, additional, Langouet, Sophie, additional, Legrand, Antoine, additional, Li, Zhuorui, additional, Le Mentec, Helene, additional, Lind, Lars, additional, Lind, P. Monica, additional, Lustig, Robert H., additional, Martin-Chouly, Corinne, additional, Munic Kos, Vesna, additional, Podechard, Normand, additional, Roepke, Troy A., additional, Sargis, Robert M., additional, Starling, Anne, additional, Tomlinson, Craig R., additional, Touma, Charbel, additional, Vondracek, Jan, additional, vom Saal, Frederick, additional, and Blumberg, Bruce, additional
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- 2022
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15. Obesity II : Establishing causal links between chemical exposures and obesity (vol 199, 115015, 2022)
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Heindel, Jerrold J., Howard, Sarah, Agay-Shay, Keren, Arrebola, Juan P., Audouze, Karine, Babin, Patrick J., Barouki, Robert, Bansal, Amita, Blanc, Etienne, Cave, Matthew C., Chatterjee, Saurabh, Chevalier, Nicolas, Choudhury, Mahua, Collier, David, Connolly, Lisa, Coumoul, Xavier, Garruti, Gabriella, Gilbertson, Michael, Hoepner, Lori A., Holloway, Alison C., Howell, George, III, Kassotis, Christopher D., Kay, Mathew K., Kim, Min Ji, Lagadic-Gossmann, Dominique, Langouet, Sophie, Legrand, Antoine, Li, Zhuorui, Le Mentec, Helene, Lind, Lars, Lind, P. Monica, Lustig, Robert H., Martin-Chouly, Corinne, Kos, Vesna Munic, Podechard, Normand, Roepke, Troy A., Sargis, Robert M., Starling, Anne, Tomlinson, Craig R., Touma, Charbel, Vondracek, Jan, vom Saal, Frederick, Blumberg, Bruce, Heindel, Jerrold J., Howard, Sarah, Agay-Shay, Keren, Arrebola, Juan P., Audouze, Karine, Babin, Patrick J., Barouki, Robert, Bansal, Amita, Blanc, Etienne, Cave, Matthew C., Chatterjee, Saurabh, Chevalier, Nicolas, Choudhury, Mahua, Collier, David, Connolly, Lisa, Coumoul, Xavier, Garruti, Gabriella, Gilbertson, Michael, Hoepner, Lori A., Holloway, Alison C., Howell, George, III, Kassotis, Christopher D., Kay, Mathew K., Kim, Min Ji, Lagadic-Gossmann, Dominique, Langouet, Sophie, Legrand, Antoine, Li, Zhuorui, Le Mentec, Helene, Lind, Lars, Lind, P. Monica, Lustig, Robert H., Martin-Chouly, Corinne, Kos, Vesna Munic, Podechard, Normand, Roepke, Troy A., Sargis, Robert M., Starling, Anne, Tomlinson, Craig R., Touma, Charbel, Vondracek, Jan, vom Saal, Frederick, and Blumberg, Bruce
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- 2022
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16. Inorganic arsenic alters expression of immune and stress response genes in activated primary human T lymphocytes
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Martin-Chouly, Corinne, Morzadec, Claudie, Bonvalet, Mélodie, Galibert, Marie-Dominique, Fardel, Olivier, and Vernhet, Laurent
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- 2011
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17. Global effects of inorganic arsenic on gene expression profile in human macrophages
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Bourdonnay, Emilie, Morzadec, Claudie, Sparfel, Lydie, Galibert, Marie-Dominique, Jouneau, Stéphane, Martin-Chouly, Corinne, Fardel, Olivier, and Vernhet, Laurent
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- 2009
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18. Modulation of matrix metalloproteinase production from human lung fibroblasts by type 4 phosphodiesterase inhibitors
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Martin-Chouly, Corinne A.E, Astier, Alexandra, Jacob, Claire, Pruniaux, Marie-Pierre, Bertrand, Claude, and Lagente, Vincent
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- 2004
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19. Phagocytosis depends on TRPV2-mediated calcium influx and requires TRPV2 in lipids rafts: alteration in macrophages from patients with cystic fibrosis
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Lévêque, Manuella, Penna, Aubin, Le Trionnaire, Sophie, Belleguic, Chantal, Desrues, Benoît, Brinchault, Graziella, Jouneau, Stéphane, Lagadic-Gossmann, Dominique, Martin-Chouly, Corinne, Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), CHU Pontchaillou [Rennes], Chemistry, Oncogenesis, Stress and Signaling (COSS), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-CRLCC Eugène Marquis (CRLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université de Rennes (UR)-CRLCC Eugène Marquis (CRLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Jonchère, Laurent
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Adult ,Male ,Adolescent ,Cystic Fibrosis ,Macrophages ,lcsh:R ,TRPV Cation Channels ,lcsh:Medicine ,Middle Aged ,Article ,Membrane Microdomains ,Phagocytosis ,[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie ,Humans ,Calcium ,Female ,lcsh:Q ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,lcsh:Science ,Cells, Cultured - Abstract
International audience; Whereas many phagocytosis steps involve ionic fluxes, the underlying ion channels remain poorly defined. As reported in mice, the calcium conducting TRPV2 channel impacts the phagocytic process. Macrophage phagocytosis is critical for defense against pathogens. In cystic fibrosis (CF), macrophages have lost their capacity to act as suppressor cells and thus play a significant role in the initiating stages leading to chronic inflammation/infection. In a previous study, we demonstrated that impaired function of CF macrophages is due to a deficient phagocytosis. The aim of the present study was to investigate TRPV2 role in the phagocytosis capacity of healthy primary human macrophage by studying its activity, its membrane localization and its recruitment in lipid rafts. In primary human macrophages, we showed that P. aeruginosa recruits TRPV2 channels at the cell surface and induced a calcium influx required for bacterial phagocytosis. We presently demonstrate that to be functional and play a role in phagocytosis, TRPV2 might require a preferential localization in lipid rafts. Furthermore, CF macrophage displays a perturbed calcium homeostasis due to a defect in TRPV2. In this context, deregulated TRPV2-signaling in CF macrophages could explain their defective phagocytosis capacity that contribute to the maintenance of chronic infection.
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- 2018
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20. Modulation of PAF production by incorporation of arachidonic acid and eicosapentaenoic acid in phospholipids of human leukemic monocyte-like cells THP-1
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Martin–Chouly, Corinne A.E, Menier, Véronique, Hichami, Aziz, Youmine, Hind, Noel, Françoise, Pedrono, Frédérique, and Legrand, Alain B
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- 2000
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21. Soluble CD14 acts as a DAMP in human macrophages: origin and involvement in inflammatory cytokine/chemokine production
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Lévêque, Manuella, primary, Jeune, Karin Simonin-Le, additional, Jouneau, Stéphane, additional, Moulis, Solenn, additional, Desrues, Benoit, additional, Belleguic, Chantal, additional, Brinchault, Graziella, additional, Le Trionnaire, Sophie, additional, Gangneux, Jean-Pierre, additional, Dimanche-Boitrel, Marie-Thérèse, additional, and Martin-Chouly, Corinne, additional
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- 2017
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22. An acidic extracellular pH switches TRAIL-induced apoptosis to a RIPK1/RIPK3/PARP1 dependent programmed necrosis in human colon cancer cells
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Jouan-Lanhouet, Sandrine, Le Moigne-Müller, Gwenaelle, Martin-Chouly, Corinne, Torriglia, Alicia, Sergent, Odile, Lagadic-Gossmann, Dominique, Dimanche-Boitrel, Marie-Thérèse, Environmental and food chemical toxicants membrane and gene targets, Signalisation et Réponses aux Agents Infectieux et Chimiques ( SeRAIC ), Université de Rennes 1 ( UR1 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -IFR140-Université de Rennes 1 ( UR1 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -IFR140, Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ), Centre de Recherche des Cordeliers ( CRC (UMR_S 872) ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Brébion, Alice, Signalisation et Réponses aux Agents Infectieux et Chimiques (SeRAIC), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Centre de Recherche des Cordeliers (CRC (UMR_S 872)), Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-IFR140-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-IFR140, Université Paris Descartes - Paris 5 (UPD5)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université de Rennes (UR)-Université de Rennes (UR), and Université de Rennes (UR)
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[SDV.CAN] Life Sciences [q-bio]/Cancer ,[SDV.CAN]Life Sciences [q-bio]/Cancer ,[ SDV.CAN ] Life Sciences [q-bio]/Cancer - Published
- 2010
23. Predictive toxicology: the paths of the future
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Detilleux, Ph, Vallier, L, Legallais, C, Leclerc, E, Prot J, M, Choucha, L, Baudoin, R, Dufresne, M, Gautier, A, Carpentier, B, Mansuy, D, Pery, Alexandre R.R., Brochot, C, Manivet, Ph, Rabilloud, Thierry, Spire, C, Coumoul, Xavier, Junot, Ch, Laprevote, O, Le Pape, A, Tourneur, E, Ben Mkaddem, S, Chassin, C, Aloulou, M, Goujon J, M, Hertif, A, Ouali, N, Vimont, S, Monteiro, R, Rondeau, E, Elbim, C, Werts, C, Vandewalle, A, Pedruzzi, E, Coant, N, Bens, M, Cluzeaud, F, Ogier-Denis, E, Pongnimitprasert, N, Babin-Chevaye, C, Fay, M, Bernard, M, Dupuy, C, Ei Benna, J, Gougerot-Pocidale M, A, Braut-Boucher, F, Pinton, Philippe, Lucioli, Joelma, Tsybulskyy, D, Joly, Baptiste, Laffitte, J, Bourges-Abella, N, Oswald, Isabelle P., Kolf-Clauw, Martine, Pierre, St, Bats A, S, Chevalier, Aline, Bui L, Ch, Ambolet-Camoit, A, Garlatti, M, Aggerbeck, M, Barouki, R, Al Khansa, I, Blanck, O, Guillouzo, A, Bars, R, Rouas, C, Bensoussan, H, Suhard, D, Tessier, C, Grandcolas, L, Pallardy, M, Gueguen, Y, Sparfel, L, Pinel-Marie M, L, Boize, M, Koscielny, S, Desmots, S, Fardel, O, Alvergnas, M, Rouleau, A, Lucchi, G, Mantion, G, Heyd, B, Richert, L, Ducoroy, P, Martin, H, Val, St, Martinon, L, Cachier, H, Yahyaoui, A, Marfaing, H, Baeza-Squiban, A, Martin-Chouly, Corinne, Bonvallet, M, Morzadec, C, Vernhet, L, Baverel, G, El Hage, M, Nazaret, R, Conjard-Duplany, A, Ferrier, B, Martin, G, Legendre, A, Lecomte, Anthony, Froment, P, Habert, R, Lemazurier, E, Robinel, F, Dupont, O, Sanfins, E, Dairou, J, Chaffotte A, F, Busi, F, Rodrigues Lima, F, Dupret J, M, Mayati, A, Le Ferrec, Eric, Levoin, N, Paris, H, Uriac, Ph, N'Diaye, M, Lagadic-Gossmann, D, Assemat, E, Boublil, L, Borot M, C, Marano, F, Martiny V, Y, Moroy, G, Badel, A, Miteva M, A, Hussain, S, Ferecatu, I, Borot, C, Andreau, K, Boland, S, Leroux, M, Zucchini-Pascal, Nathalie, Peyre, L, Rahmani, Roger, Buron, N, Porcedou, M, Fromenty, B, Borgne-Sanchez, A, Rogue, A, Claude, N, Le Guével, Rémy, Institut National de l'Environnement Industriel et des Risques (INERIS), Laboratoire pharmaceutique Biologie Servier, Biologie Servier, Pharmacologie, toxicologie et signalisation cellulaire (U747), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Faculté de Médecine Xavier Bichat, Centre de recherche biomédicale Bichat-Beaujon (CRB3), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Unité de recherche Pharmacologie-Toxicologie (UPT), Institut National de la Recherche Agronomique (INRA), Toxicité environnementale, cibles thérapeutiques, signalisation cellulaire (T3S - UMR_S 1124), Cytokines, chimiokines et immunopathologie, Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de biostatistique et d'épidémiologie (SBE), Direction de la recherche clinique [Gustave Roussy], Institut Gustave Roussy (IGR)-Institut Gustave Roussy (IGR), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Fonctions et dysfonctions épithéliales - UFC (EA 4267) (FDE), Université de Franche-Comté (UFC), Plate-forme Protéomique CLIPP - Clinical and Innovation Proteomic Platform [Dijon] (CLIPP), Franche-Comté Électronique Mécanique, Thermique et Optique - Sciences et Technologies (UMR 6174) (FEMTO-ST), Université de Franche-Comté (UFC)-Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Supérieure de Mécanique et des Microtechniques (ENSMM)-Université de Technologie de Belfort-Montbeliard (UTBM)-Université de Franche-Comté (UFC)-Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Supérieure de Mécanique et des Microtechniques (ENSMM)-Université de Technologie de Belfort-Montbeliard (UTBM)-Institut de Chimie Moléculaire de l'Université de Bourgogne [Dijon] (ICMUB), Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS)-Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS), Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] (LSCE), Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Centre National de la Recherche Scientifique (CNRS), Cellules Souches et Radiations (SCSR (U967 / UMR-E_008)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris-Sud - Paris 11 (UP11), Laboratoire Bioprojet, Institut des Sciences Chimiques de Rennes (ISCR), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes-Centre National de la Recherche Scientifique (CNRS), Unité de Biologie Fonctionnelle et Adaptative (BFA (UMR_8251 / U1133)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Mitologics SAS, Hôpital Robert Debré, Biomécanique et Bioingénierie (BMBI), Université de Technologie de Compiègne (UTC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de radiotoxicologie expérimentale (IRSN/DRPH/SRBE/LRTOX), Service de RadioBiologie et d'Epidémiologie (IRSN/DRPH/SRBE), Institut de Radioprotection et de Sûreté Nucléaire (IRSN)-Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Université de Technologie de Belfort-Montbeliard (UTBM)-Ecole Nationale Supérieure de Mécanique et des Microtechniques (ENSMM)-Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université de Technologie de Belfort-Montbeliard (UTBM)-Ecole Nationale Supérieure de Mécanique et des Microtechniques (ENSMM)-Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Institut de Chimie Moléculaire de l'Université de Bourgogne [Dijon] (ICMUB), Université de Bourgogne (UB)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Bourgogne (UB)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Stabilité génétique, Cellules Souches et Radiations (SCSR (U_967)), Université Paris-Sud - Paris 11 (UP11)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université Paris Descartes - Paris 5 (UPD5)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Sud - Paris 11 (UP11), Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Institut National de la Santé et de la Recherche Médicale (INSERM)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université d'Angers (UA), Université de Technologie de Belfort-Montbeliard (UTBM)-Ecole Nationale Supérieure de Mécanique et des Microtechniques (ENSMM)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre National de la Recherche Scientifique (CNRS)-Université de Technologie de Belfort-Montbeliard (UTBM)-Ecole Nationale Supérieure de Mécanique et des Microtechniques (ENSMM)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie Moléculaire de l'Université de Bourgogne [Dijon] (ICMUB), Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Université Paris-Sud - Paris 11 (UP11)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA), Université Paris-Sud - Paris 11 (UP11)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Supérieure de Chimie de Rennes-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES), Institut National de l'Environnement Industriel et des Risques ( INERIS ), Physiologie Cellulaire des Regulations Hormonales, Nutritionnelles et Pharmacologiques, Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Centre de recherche biomédicale Bichat-Beaujon ( CRB3 ), Université Paris Diderot - Paris 7 ( UPD7 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Unité de recherche Pharmacologie-Toxicologie ( UPT ), Institut National de la Recherche Agronomique ( INRA ), Toxicologie, Pharmacologie et Signalisation Cellulaire ( U1124 ), Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université Paris Descartes - Paris 5 ( UPD5 ) -Centre National de la Recherche Scientifique ( CNRS ), Université Paris-Sud - Paris 11 ( UP11 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Service de biostatistique et d'épidémiologie ( SBE ), Institut Gustave Roussy ( IGR ) -Institut Gustave Roussy ( IGR ), Institut de recherche, santé, environnement et travail ( Irset ), Université d'Angers ( UA ) -Université de Rennes 1 ( UR1 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -École des Hautes Études en Santé Publique [EHESP] ( EHESP ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) -Université des Antilles ( UA ), Fonctions et dysfonctions épithéliales - UFC (EA 4267) ( FDE ), Université de Franche-Comté ( UFC ), Plate-forme Protéomique CLIPP - Clinical and Innovation Proteomic Platform [Dijon] ( CLIPP ), Franche-Comté Électronique Mécanique, Thermique et Optique - Sciences et Technologies (UMR 6174) ( FEMTO-ST ), Université de Franche-Comté ( UFC ) -Centre National de la Recherche Scientifique ( CNRS ) -Ecole Nationale Supérieure de Mécanique et des Microtechniques ( ENSMM ) -Université de Technologie de Belfort-Montbeliard ( UTBM ) -Université de Franche-Comté ( UFC ) -Centre National de la Recherche Scientifique ( CNRS ) -Ecole Nationale Supérieure de Mécanique et des Microtechniques ( ENSMM ) -Université de Technologie de Belfort-Montbeliard ( UTBM ) -Institut de Chimie Moléculaire de l'Université de Bourgogne [Dijon] ( ICMUB ), Université de Bourgogne ( UB ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Bourgogne ( UB ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] ( LSCE ), Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université de Versailles Saint-Quentin-en-Yvelines ( UVSQ ) -Centre National de la Recherche Scientifique ( CNRS ), Cellules Souches et Radiations ( SCSR - U 967 ), Université Paris-Sud - Paris 11 ( UP11 ) -Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris Diderot - Paris 7 ( UPD7 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Institut des Sciences Chimiques de Rennes ( ISCR ), Université de Rennes 1 ( UR1 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -Ecole Nationale Supérieure de Chimie de Rennes-Institut National des Sciences Appliquées ( INSA ) -Centre National de la Recherche Scientifique ( CNRS ), Biologie Fonctionnelle et Adaptative ( BFA ), and Université Paris Diderot - Paris 7 ( UPD7 ) -Centre National de la Recherche Scientifique ( CNRS )
- Subjects
[ SDV ] Life Sciences [q-bio] ,[SDV.TOX]Life Sciences [q-bio]/Toxicology ,[SDV]Life Sciences [q-bio] ,ComputingMilieux_MISCELLANEOUS - Abstract
National audience
- Published
- 2010
24. An acidic extracellular pH tumoral environment switches TRAIL-induced apoptosis to necrosis via PARP-1 activation in human colon and liver cancer cells
- Author
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Jouan-Lanhouet, Sandrine, Le Moigne-Müller, Gwenaelle, Martin-Chouly, Corinne, Sergent, Odile, Lagadic-Gossmann, Dominique, Dimanche-Boitrel, Marie-Thérèse, Environmental and food chemical toxicants membrane and gene targets, Signalisation et Réponses aux Agents Infectieux et Chimiques (SeRAIC), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Brébion, Alice, Université de Rennes (UR)-Université de Rennes (UR), and Université de Rennes (UR)
- Subjects
[SDV.IMM] Life Sciences [q-bio]/Immunology ,[SDV.IMM]Life Sciences [q-bio]/Immunology - Published
- 2010
25. Impaired Functions of Macrophage from Cystic Fibrosis Patients: CD11b, TLR-5 Decrease and sCD14, Inflammatory Cytokines Increase
- Author
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Simonin-Le Jeune, Karin, primary, Le Jeune, André, additional, Jouneau, Stéphane, additional, Belleguic, Chantal, additional, Roux, Pierre-François, additional, Jaguin, Marie, additional, Dimanche-Boitre, Marie-Thérèse, additional, Lecureur, Valérie, additional, Leclercq, Caroline, additional, Desrues, Benoît, additional, Brinchault, Graziella, additional, Gangneux, Jean-Pierre, additional, and Martin-Chouly, Corinne, additional
- Published
- 2013
- Full Text
- View/download PDF
26. Anti-Inflammatory Effect of Fluvastatin on IL-8 Production Induced by Pseudomonas aeruginosa and Aspergillus fumigatus Antigens in Cystic Fibrosis
- Author
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Jouneau, Stéphane, primary, Bonizec, Mélanie, additional, Belleguic, Chantal, additional, Desrues, Benoit, additional, Brinchault, Graziella, additional, Galaine, Jeanne, additional, Gangneux, Jean-Pierre, additional, and Martin-Chouly, Corinne, additional
- Published
- 2011
- Full Text
- View/download PDF
27. Regulation of MMP/TIMP Balance as Therapeutic Target in Pulmonary Diseases
- Author
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Martin-Chouly, Corinne, primary, Guillot, Stephanie, additional, Jouneau, Stephane, additional, Caulet-Maugendre, Sylvie, additional, Vernhet, Laurent, additional, Lagente, Vincent, additional, and Delaval, Philippe, additional
- Published
- 2006
- Full Text
- View/download PDF
28. INCREASED EXTRACELLULAR MATRIX METALLOPROTEINASE INDUCER (EMMPRIN) EXPRESSION IN PULMONARY FIBROSIS
- Author
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Guillot, Stéphanie, primary, Delaval, Philippe, additional, Brinchault, Graziella, additional, Caulet-Maugendre, Sylvie, additional, Depince, Alexandra, additional, Lena, Hervé, additional, Delatour, Bertrand, additional, Lagente, Vincent, additional, and Martin-Chouly, Corinne, additional
- Published
- 2006
- Full Text
- View/download PDF
29. Selective PDE4 inhibitors as potent anti-inflammatory drugs for the treatment of airway diseases
- Author
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Lagente, Vincent, primary, Martin-Chouly, Corinne, additional, Boichot, Elisabeth, additional, Martins, Marco A, additional, and Silva, Patrica MR, additional
- Published
- 2005
- Full Text
- View/download PDF
30. Synthesis and Potential Anti-Inflammatory Activity of Some Tetrahydrophthalazinones
- Author
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Gouault, Nicolas, primary, Pinel, Benoit, additional, Cupif, Jean-Francois, additional, Depince, Alexandra, additional, Martin-Chouly, Corinne A.E., additional, Belleguic, Chantal, additional, and David, Michele, additional
- Published
- 2004
- Full Text
- View/download PDF
31. Solid-phase synthesis and evaluation of libraries of substituted 4,5-dihydropyridazinones as vasodilator agents
- Author
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Gouault, Nicolas, primary, Martin-Chouly, Corinne A E, additional, Lugnier, Claire, additional, Cupif, Jean-François, additional, Tonnelier, Amaury, additional, Feger, Frédéric, additional, Lagente, Vincent, additional, and David, Michèle, additional
- Published
- 2004
- Full Text
- View/download PDF
32. Phagocytosis depends on TRPV2-mediated calcium influx and requires TRPV2 in lipids rafts: alteration in macrophages from patients with cystic fibrosis.
- Author
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Lévêque M, Penna A, Le Trionnaire S, Belleguic C, Desrues B, Brinchault G, Jouneau S, Lagadic-Gossmann D, and Martin-Chouly C
- Subjects
- Adolescent, Adult, Cells, Cultured, Female, Humans, Male, Middle Aged, Calcium metabolism, Cystic Fibrosis metabolism, Macrophages metabolism, Membrane Microdomains metabolism, Phagocytosis, TRPV Cation Channels metabolism
- Abstract
Whereas many phagocytosis steps involve ionic fluxes, the underlying ion channels remain poorly defined. As reported in mice, the calcium conducting TRPV2 channel impacts the phagocytic process. Macrophage phagocytosis is critical for defense against pathogens. In cystic fibrosis (CF), macrophages have lost their capacity to act as suppressor cells and thus play a significant role in the initiating stages leading to chronic inflammation/infection. In a previous study, we demonstrated that impaired function of CF macrophages is due to a deficient phagocytosis. The aim of the present study was to investigate TRPV2 role in the phagocytosis capacity of healthy primary human macrophage by studying its activity, its membrane localization and its recruitment in lipid rafts. In primary human macrophages, we showed that P. aeruginosa recruits TRPV2 channels at the cell surface and induced a calcium influx required for bacterial phagocytosis. We presently demonstrate that to be functional and play a role in phagocytosis, TRPV2 might require a preferential localization in lipid rafts. Furthermore, CF macrophage displays a perturbed calcium homeostasis due to a defect in TRPV2. In this context, deregulated TRPV2-signaling in CF macrophages could explain their defective phagocytosis capacity that contribute to the maintenance of chronic infection.
- Published
- 2018
- Full Text
- View/download PDF
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