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1. Pharmacokinetics, Efficacy, and Safety of a SARS-CoV-2 Antibody Treatment in Pediatric Participants: An Open-Label Addendum of a Placebo-Controlled, Randomized Phase 2/3 Trial

Author

Himanshu P. Upadhyaya, Jenny Y. Chien, Amanda J. Long, Martin S. Bohm, Nicole L. Kallewaard, Lisa F. Macpherson, Dipak R. Patel, Matthew M. Hufford, Constance J. Krull, Jocelyn Y. Ang, Peter Chen, William J. Muller, Jeffrey A. Potts, Timothy Quinn, Mark Williams, and BLAZE-1 Investigators

Subjects
Bamlanivimab, COVID-19, Etesevimab, Monoclonal antibodies, Pediatric, Pharmacokinetics, Infectious and parasitic diseases, RC109-216
Abstract

Abstract Introduction Bamlanivimab and etesevimab (BAM + ETE) are monoclonal antibodies (mAbs) effective in reducing COVID-19-related hospitalizations and all-cause mortality in adult participants at increased risk for severe disease. We present pharmacokinetic (PK), efficacy, and safety results from pediatric participants ( 12 to

Published
2023
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