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1. A Volumetric Metric for Monitoring Intracranial Aneurysms: Repeatability and Growth Criteria in a Longitudinal MR Imaging Study

Author

Liu, X, Haraldsson, H, Wang, Y, Kao, E, Ballweber, M, Martin, AJ, McCulloch, CE, Faraji, F, Saloner, D, and Group, for the UCSF Intracranial Aneurysm Monitoring

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Brain Disorders, Clinical Research, Neurosciences, Stroke, Biomedical Imaging, 4.2 Evaluation of markers and technologies, Detection, screening and diagnosis, Carotid Artery, Internal, Humans, Intracranial Aneurysm, Magnetic Resonance Angiography, Magnetic Resonance Imaging, Reproducibility of Results, UCSF Intracranial Aneurysm Monitoring Group, Nuclear Medicine & Medical Imaging, Clinical sciences, Physical chemistry
Abstract

Background and purposeThe reliability of contrast-enhanced MRA in monitoring serial volumetric changes of unruptured intracranial aneurysms has not been established. We aimed to determine the coefficient of variance of contrast-enhanced MRA in measuring aneurysm volumes, thus establishing criteria for aneurysm growth and permitting identification of variables predictive of growth.Materials and methodsAneurysm volumes were measured from serial contrast-enhanced MRA studies of patients with untreated intracranial aneurysms who underwent >2 sequential MR imaging evaluations. After coregistering all sequential studies in 3D space for each aneurysm and signal intensity normalization, aneurysm volume was determined across all time points. A linear mixed effects model was built to estimate the coefficient of variance of the measurement as well as to determine predictive variables. Growth was defined as relative growth exceeding 2 times the measurement coefficient of variance (sudden growth, as 4 times the coefficient of variance).ResultsA total of 95 patients with 112 aneurysms were included (5.9 scans during 4.0 years on average, 616 scan measurements in total). The coefficient of variance was 5.5% of the aneurysm volume, and the relative growth rate was dependent on the location: anterior cerebral artery, 4.52% per year; vertebral artery, 2.46% per year; middle cerebral artery, 2.74% per year; basilar artery, 2.36% per year; internal carotid artery, 1.14% per year. Thirty-six of 112 (32%) aneurysms were characterized as growing, and 11/36 of them had an episode of sudden growth.ConclusionsVolume measurement of unruptured intracranial aneurysms by contrast-enhanced MRA seems a reliable metric for tracking the growth trajectory of aneurysms. Furthermore, the aneurysm growth rate differs among different locations.

Published
2021

2. Novel bacterial clade reveals origin of form I Rubisco

Author

Banda, Douglas M, Pereira, Jose H, Liu, Albert K, Orr, Douglas J, Hammel, Michal, He, Christine, Parry, Martin AJ, Carmo-Silva, Elizabete, Adams, Paul D, Banfield, Jillian F, and Shih, Patrick M

Subjects
Biological Sciences, Ecology, Cyanobacteria, Molecular Structure, Photosynthesis, Phylogeny, Plant Physiological Phenomena, Ribulose-Bisphosphate Carboxylase, Plant Biology, Crop and Pasture Production, Plant biology
Abstract

Rubisco sustains the biosphere through the fixation of CO2 into biomass. In plants and cyanobacteria, form I Rubisco is structurally comprised of large and small subunits, whereas all other Rubisco forms lack small subunits. The rise of the form I complex through the innovation of small subunits represents a key, yet poorly understood, transition in Rubisco's evolution. Through metagenomic analyses, we discovered a previously uncharacterized clade sister to form I Rubisco that evolved without small subunits. This clade diverged before the evolution of cyanobacteria and the origin of the small subunit; thus, it provides a unique reference point to advance our understanding of form I Rubisco evolution. Structural and kinetic data presented here reveal how a proto-form I Rubisco assembled and functioned without the structural stability imparted from small subunits. Our findings provide insight into a key evolutionary transition of the most abundant enzyme on Earth and the predominant entry point for nearly all global organic carbon.

Published
2020

4. Toward Precision and Reproducibility of Diffusion Tensor Imaging: A Multicenter Diffusion Phantom and Traveling Volunteer Study

Author

Palacios, EM, Martin, AJ, Boss, MA, Ezekiel, F, Chang, YS, Yuh, EL, Vassar, MJ, Schnyer, DM, MacDonald, CL, Crawford, KL, Irimia, A, Toga, AW, and Mukherjee, P

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Bioengineering, Prevention, Neurosciences, Biomedical Imaging, Clinical Research, Neurological, Good Health and Well Being, Brain, Diffusion Tensor Imaging, Humans, Neuroimaging, Phantoms, Imaging, Reproducibility of Results, Volunteers, TRACK-TBI Investigators, Nuclear Medicine & Medical Imaging, Clinical sciences, Physical chemistry
Abstract

Background and purposePrecision medicine is an approach to disease diagnosis, treatment, and prevention that relies on quantitative biomarkers that minimize the variability of individual patient measurements. The aim of this study was to assess the intersite variability after harmonization of a high-angular-resolution 3T diffusion tensor imaging protocol across 13 scanners at the 11 academic medical centers participating in the Transforming Research and Clinical Knowledge in Traumatic Brain Injury multisite study.Materials and methodsDiffusion MR imaging was acquired from a novel isotropic diffusion phantom developed at the National Institute of Standards and Technology and from the brain of a traveling volunteer on thirteen 3T MR imaging scanners representing 3 major vendors (GE Healthcare, Philips Healthcare, and Siemens). Means of the DTI parameters and their coefficients of variation across scanners were calculated for each DTI metric and white matter tract.ResultsFor the National Institute of Standards and Technology diffusion phantom, the coefficients of variation of the apparent diffusion coefficient across the 13 scanners was

Published
2017

6. Redesigning photosynthesis to sustainably meet global food and bioenergy demand

Author

Ort, Donald R, Merchant, Sabeeha S, Alric, Jean, Barkan, Alice, Blankenship, Robert E, Bock, Ralph, Croce, Roberta, Hanson, Maureen R, Hibberd, Julian M, Long, Stephen P, Moore, Thomas A, Moroney, James, Niyogi, Krishna K, Parry, Martin AJ, Peralta-Yahya, Pamela P, Prince, Roger C, Redding, Kevin E, Spalding, Martin H, van Wijk, Klaas J, Vermaas, Wim FJ, von Caemmerer, Susanne, Weber, Andreas PM, Yeates, Todd O, Yuan, Joshua S, and Zhu, Xin Guang

Subjects
Zero Hunger, Biofuels, Crops, Agricultural, Food Supply, Photosynthesis, light capture/conversion, carbon capture/conversion, smart canopy, enabling plant biotechnology tools, sustainable crop production
Abstract

The world's crop productivity is stagnating whereas population growth, rising affluence, and mandates for biofuels put increasing demands on agriculture. Meanwhile, demand for increasing cropland competes with equally crucial global sustainability and environmental protection needs. Addressing this looming agricultural crisis will be one of our greatest scientific challenges in the coming decades, and success will require substantial improvements at many levels. We assert that increasing the efficiency and productivity of photosynthesis in crop plants will be essential if this grand challenge is to be met. Here, we explore an array of prospective redesigns of plant systems at various scales, all aimed at increasing crop yields through improved photosynthetic efficiency and performance. Prospects range from straightforward alterations, already supported by preliminary evidence of feasibility, to substantial redesigns that are currently only conceptual, but that may be enabled by new developments in synthetic biology. Although some proposed redesigns are certain to face obstacles that will require alternate routes, the efforts should lead to new discoveries and technical advances with important impacts on the global problem of crop productivity and bioenergy production.

Published
2015

7. Endovascular catheter for magnetic navigation under MR imaging guidance: evaluation of safety in vivo at 1.5T.

Author

Hetts, SW, Saeed, M, Martin, AJ, Evans, L, Bernhardt, AF, Malba, V, Settecase, F, Do, L, Yee, EJ, Losey, A, Sincic, R, Lillaney, P, Roy, S, Arenson, RL, and Wilson, MW

Subjects
Carotid Arteries, Animals, Swine, Carotid Artery Injuries, Burns, Electric, Catheterization, Equipment Design, Equipment Failure Analysis, Equipment Safety, Magnetic Resonance Imaging, Interventional, Biomedical Imaging, Clinical Sciences, Neurosciences, Nuclear Medicine & Medical Imaging
Abstract

Background and purposeEndovascular navigation under MR imaging guidance can be facilitated by a catheter with steerable microcoils on the tip. Not only do microcoils create visible artifacts allowing catheter tracking, but also they create a small magnetic moment permitting remote-controlled catheter tip deflection. A side product of catheter tip electrical currents, however, is the heat that might damage blood vessels. We sought to determine the upper boundary of electrical currents safely usable at 1.5T in a coil-tipped microcatheter system.Materials and methodsAlumina tubes with solenoid copper coils were attached to neurovascular microcatheters with heat shrink-wrap. Catheters were tested in carotid arteries of 8 pigs. The catheters were advanced under x-ray fluoroscopy and MR imaging. Currents from 0 mA to 700 mA were applied to test heating and potential vascular damage. Postmortem histologic analysis was the primary endpoint.ResultsSeveral heat-mitigation strategies demonstrated negligible vascular damage compared with control arteries. Coil currents ≤300 mA resulted in no damage (0/58 samples) compared with 9 (25%) of 36 samples for > 300-mA activations (P = .0001). Tip coil activation ≤1 minute and a proximal carotid guide catheter saline drip > 2 mL/minute also had a nonsignificantly lower likelihood of vascular damage. For catheter tip coil activations ≤300 mA for ≤1 minute in normal carotid flow, 0 of 43 samples had tissue damage.ConclusionsActivations of copper coils at the tip of microcatheters at low currents in 1.5T MR scanners can be achieved without significant damage to blood vessel walls in a controlled experimental setting. Further optimization of catheter design and procedure protocols is necessary for safe remote control magnetic catheter guidance.

Published
2013

8. Rapid Inverse Planning for Pressure-Driven Drug Infusions in the Brain

Author

Bankiewicz, Krzysztof, Rosenbluth, KH, Martin, AJ, Mittermeyer, S, Eschermann, J, Dickinson, PJ, and Bankiewicz, KS

Abstract

Infusing drugs directly into the brain is advantageous to oral or intravenous delivery for large molecules or drugs requiring high local concentrations with low off-target exposure. However, surgeons manually planning the cannula position for drug delivery

Published
2013

11. SCORE: a randomised controlled trial evaluating shared care (general practitioner and oncologist) follow-up compared to usual oncologist follow-up for survivors of colorectal cancer

Author

Jefford, M, Emery, JD, Martin, AJ, Lourenco, RDA, Lisy, K, Grunfeld, E, Mohamed, MA, King, D, Tebbutt, NC, Lee, M, Mehrnejad, A, Burgess, A, Marker, J, Eggins, R, Carrello, J, Thomas, H, Schofield, P, Jefford, M, Emery, JD, Martin, AJ, Lourenco, RDA, Lisy, K, Grunfeld, E, Mohamed, MA, King, D, Tebbutt, NC, Lee, M, Mehrnejad, A, Burgess, A, Marker, J, Eggins, R, Carrello, J, Thomas, H, and Schofield, P

Abstract

BACKGROUND: SCORE is the first randomised controlled trial (RCT) to examine shared oncologist and general practitioner (GP) follow-up for survivors of colorectal cancer (CRC). SCORE aimed to show that shared care (SC) was non-inferior to usual care (UC) on the EORTC QLQ-C30 Global Health Status/Quality of Life (GHQ-QoL) scale to 12 months. METHODS: The study recruited patients from five public hospitals in Melbourne, Australia between February 2017 and May 2021. Patients post curative intent treatment for stage I-III CRC underwent 1:1 randomisation to SC and UC. SC replaced two oncologist visits with GP visits and included a survivorship care plan and primary care management guidelines. Assessments were at baseline, 6 and 12 months. Difference between groups on GHQ-QoL to 12 months was estimated from a mixed model for repeated measures (MMRM), with a non-inferiority margin (NIM) of -10 points. Secondary endpoints included quality of life (QoL); patient perceptions of care; costs and clinical care processes (CEA tests, recurrences). Registration ACTRN12617000004369p. FINDINGS: 150 consenting patients were randomised to SC (N = 74) or UC (N = 76); 11 GPs declined. The mean (SD) GHQ-QoL scores at 12 months were 72 (20.2) for SC versus 73 (17.2) for UC. The MMRM mean estimate of GHQ-QoL across the 6 month and 12 month follow-up was 69 for SC and 73 for UC, mean difference -4.0 (95% CI: -9.0 to 0.9). The lower limit of the 95% CI did not cross the NIM. There was no clear evidence of differences on other QoL, unmet needs or satisfaction scales. At 12 months, the majority preferred SC (40/63; 63%) in the SC group, with equal preference for SC (22/62; 35%) and specialist care (22/62; 35%) in UC group. CEA completion was higher in SC. Recurrences similar between arms. Patients in SC on average incurred USD314 less in health costs versus UC patients. INTERPRETATION: SC seems to be an appropriate and cost-effective model of follow-up for CRC survivors. FUNDING: Victorian Cance

Published
2023

12. SCORE: A multisite randomised controlled trial evaluating shared care for colorectal cancer survivors.

Author

Jefford, M, Emery, JD, Martin, AJ, De Abreu Lourenco, R, Lisy, K, Mohamed, MA, King, D, Tebbutt, NC, Lee, M, Mehrnejad, A, Burgess, A, Marker, J, Eggins, R, Carrello, J, Schofield, P, Jefford, M, Emery, JD, Martin, AJ, De Abreu Lourenco, R, Lisy, K, Mohamed, MA, King, D, Tebbutt, NC, Lee, M, Mehrnejad, A, Burgess, A, Marker, J, Eggins, R, Carrello, J, and Schofield, P

Abstract

84 Background: Colorectal cancer (CRC) survivorship is rising. Few studies have considered shared follow up (FU) care (SC) between oncologists and primary care providers (PCPs). SCORE is the first large RCT of SC for CRC survivors. Aim: to compare SC with usual care (UC) for CRC survivors. Primary objective: assess the effect of SC vs UC on the EORTC QLQ-C30 Global Health Status/Quality of Life (GHQ-QoL) scale to 12 months (mo). Secondary objectives: assess the effect of SC vs UC on QoL; pt perceptions of care; costs; clinical care processes (CEA tests, recurrences); and feasibility (recruitment, completion rate). Methods: Pts had stage I-III CRC, completed all treatments within 3 mo, spoke English, had a PCP, and no prior cancer. After pt consent, PCP could opt out. Pts were randomised 1 to 1 to SC or UC. SC replaced 2 routine oncologist visits with PCP visits and included a survivorship care plan, concerns checklist and management guidelines for the PCP. PCPs were asked to request CEA tests at 3 and 9 mo visits. Pts completed measures at baseline (BL) and at 6 and 12 mo FU. An estimate of the difference (diff) between groups on GHQ-QoL to 12 mo was obtained from a mixed model for repeated measures (MMRM). The test of non-inferiority was performed by evaluating the lower limit of the two-sided 95% confidence interval (CI) for the estimated diff (SC–UC) against a pre-specified non-inferiority margin (NIM) of -10 points. All randomised pts with available data were included in the primary analysis. Per-protocol population (PPP) comprised all randomised pts with ≥ 1 post-BL questionnaire (6 +/or 12 mo) and, for SC, ≥ 1 of the PCP visits. Results: 150 pts were randomised to SC (N=74) or UC (N=76); 11 PCPs declined. Median age 63 years, 39% women, 24% had radiotherapy. Primary: colon (59%), rectum (32%), overlapping (9%). 138/150 (92%) had BL and ≥1 post-BL GHQ-QoL score. 65/74 (88%) of SC pts attended 3- and/or 9-mo PCP visit. The mean (SD) GH

Published
2023

15. The Benzo Research Project: An evaluation of recreational benzodiazepine use amongst UK young people (18-25)

Author

Bright, Joanna K, Martin, AJ, Richards, Monica, Morie, Marie, Ezquerra-Romano, Ivan, Uszpolewicz, Julie, and Stewart, Lauren

Subjects
lived experiences, substance use, drugs and alcohol education, addiction, harm reduction, drug policy, benzodiazepines, UK drug policy, young people
Abstract

The Benzo Research Project is a student-led group researching recreational benzodiazepine (benzo) use in young people across the UK with the aim of sparking conversation and raising awareness of the emerging issues surrounding this. It was set up in Summer 2021, and has had over 50 young people volunteering 4,000 hours over 16 months, conducted entirely online via WhatsApp group chats and Zoom calls. Over the course of 16 months, the Benzo Research Project collected 81 anonymous testimonies and counting on non-medical benzo use amongst young people (18-25) in the UK. We conducted an inductive thematic analysis of 73 testimonies received between March and September 2022. Respondents were prompted with questions on: Young people’s experiences on benzos, whether positive, neutral, or negative Their opinions on the connection between benzo use, education, and music subcultures Previous experiences of accessing support services What effective drug support would look like to them Blackouts Experiences of those who’ve been around others on benzos but not taken it themselves When submitting, participants could choose to give us demographic information such as place of residence and gender, however this was optional. More information on the submission process, our privacy policy (Appendix 4) and the consent form (Appendix 3) can be found in the appendix section of this report., Corrected percentage and number of testimonies experiencing blackouts (p. 28)., {"references":["Alonso, Fernanda. 2015. 'Synthetic Drugs: Prohibition's Latest Creation'. 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Wood. 2020. 'Nonmedical Use of Benzodiazepines and Z-Drugs in the UK'. British Journal of Clinical Pharmacology 87 (4): 1676–83. https://doi.org/10.1111/bcp.14397.","Hofeldt, Ursula. 2021. 'Supporting Frontline Workers to Respond to the Challenge of Street Benzos'. Scottish Frontline Network (blog). 2021. https://www.frontlinenetwork.org.uk/news-and-views/2021/07/supporting-frontline-worker s-to-respond-to-the-challenge-of-street-benzos/.","Home Office, Department of Health and Social Care, Ministry of Justice, Department for Work and Pensions, Department for Education, and Department for Levelling Up, Housing and Communities. 2020. 'From Harm to Hope: A 10-Year Drugs Plan to Cut Crime and Save Lives'. HM Government. https://www.gov.uk/government/publications/from-harm-to-hope-a-10-year-drugs-plan-to- cut-crime-and-save-lives.","Iversen, Les, and Ray Hill. 2016. 'Diversion and Illicit Supply of Medicines'. Advisory Council on the Misuse of Drugs. https://www.gov.uk/government/publications/diversion-illicit-supply-of-medicines.","Jenkins, Emily K., Allie Slemon, and Rebecca J. Haines-Saah. 2017. 'Developing Harm Reduction in the Context of Youth Substance Use: Insights from a Multi-Site Qualitative Analysis of Young People's Harm Minimization Strategies'. Harm Reduction Journal 14 (1): 53. https://doi.org/10.1186/s12954-017-0180-z.","Jhanjee, Sonali. 2014. 'Evidence Based Psychosocial Interventions in Substance Use'. Indian Journal of Psychological Medicine 36 (2): 112–18. https://doi.org/10.4103/0253-7176.130960.","Kapil, V., J. L. Green, C. Le Lait, C. M. Wood, and P. M. Dargan. 2014. 'Misuse of Benzodiazepines and Z-Drugs in the UK'. The British Journal of Psychiatry 205 (5): 407–8. https://doi.org/10.1192/bjp.bp.114.149252.","Klebovich, I., and M. Abermann. 1993a. '[Pharmacokinetics and metabolism of tofizopam (Grandaxin)]'. Acta Pharmaceutica Hungarica 63 (2): 83–90.","Klebovich, I., and M. Abermann. 1993b. '[Pharmacokinetics and metabolism of tofizopam (Grandaxin)]'. Acta Pharmaceutica Hungarica 63 (2): 83–90.","Lee, Nayeong, and Miriam Boeri. 2017. 'Managing Stigma: Women Drug Users and Recovery Services'. Fusio : The Bentley Undergraduate Research Journal 1 (2): 65–94.","Marchand, Kirsten, Scott Beaumont, Jordan Westfall, Scott MacDonald, Scott Harrison, David C Marsh, Martin T Schechter, and Eugenia Oviedo-Joekes. 2018. 'Patient-Centred Care for Addiction Treatment: A Scoping Review Protocol'. BMJ Open 8 (12): e024588. https://doi.org/10.1136/bmjopen-2018-024588.","Martin, A. J. 2022. 'Benzodiazepines and Post-War America'. Volteface: The Benzo Blogs (blog). 15 June 2022. https://volteface.me/benzodiazepines-post-war-america/, https://volteface.me/benzodiazepines-post-war-america/.","Mind. 2021. 'Coronavirus: The Consequences for Mental Health'. London: Mind. https://www.mind.org.uk/coronavirus-we-are-here-for-you/coronavirus-research/.","Moore, K. E., M. D. Stein, M. E. Kurth, L. Stevens, M. Hailemariam, Y. C. Schonbrun, and J. E. Johnson. 2020. 'Risk Factors for Self-Stigma among Incarcerated Women with Alcohol Use Disorder.' Stigma and Health 5 (2): 158–67. https://doi.org/10.1037/sah0000182.","Moosmann, Bjoern, Philippe Bisel, and Volker Auwärter. 2014. 'Characterization of the Designer Benzodiazepine Diclazepam and Preliminary Data on Its Metabolism and Pharmacokinetics'. Drug Testing and Analysis 6 (7–8): 757–63. https://doi.org/10.1002/dta.1628.","Mosher, Clayton J., and Scott Akins. 2007. Drugs and Drug Policy: The Control of Consciousness Alteration. SAGE.","Murphy, Kevin D., Sharon Lambert, Suzanne McCarthy, Laura J. Sahm, and Stephen Byrne. 2018. '\"You Don't Feel\": The Experience of Youth Benzodiazepine Misuse in Ireland'. Journal of Psychoactive Drugs 50 (2): 121–28. https://doi.org/10.1080/02791072.2017.1371365.","National Records of Scotland. 2021. 'Drug-Related Deaths in Scotland in 2020'. Document. National Statistics. https://www.nrscotland.gov.uk/statistics-and-data/statistics/statistics-by-theme/vital-event s/deaths/drug-related-deaths-in-scotland/2020.","Neale, Joanne. 2016. 'Iterative Categorization (IC): A Systematic Technique for Analysing Qualitative Data'. Addiction (Abingdon, England) 111 (6): 1096–1106. https://doi.org/10.1111/add.13314.","NHS England and Personalised Care Group. 2019. 'Universal Personalised Care: Impementing the Comprehensive Model'. Guidance. Personalised Care. London: NHS. https://www.england.nhs.uk/publication/universal-personalised-care-implementing-the-co mprehensive-model/.","Olphen, Juliana van, Michele J. Eliason, Nicholas Freudenberg, and Marilyn Barnes. 2009. 'Nowhere to Go: How Stigma Limits the Options of Female Drug Users after Release from Jail'. Substance Abuse Treatment, Prevention, and Policy 4 (1): 10. https://doi.org/10.1186/1747-597X-4-10.","Oppenheim, Maya. 2022. 'More Women than Men Prescribed Anti-Anxiety Drugs \"Harder to Come off than Heroin\"'. The Independent. 4 October 2022. https://www.independent.co.uk/news/uk/home-news/benzodiazepines-more-women-pres cribed-than-men-b2184230.html.","Ozcubukcu, Arda, and Graham Towl. 2022. 'Illicit Drug Use in Universities: Zero Tolerance or Harm Reduction?' Debate Paper 29. Oxford: Higher Education Policy Institute (HEPI). https://www.hepi.ac.uk/2022/03/03/illicit-drug-use-in-universities-zero-tolerance-or-harm- reduction/.","Ozcubukcu, Arda, and Graham Towl. 2022. 'Illicit Drug Use in Universities: Zero Tolerance or Harm Reduction?' Debate Paper 29. Oxford: Higher Education Policy Institute (HEPI). https://www.hepi.ac.uk/2022/03/03/illicit-drug-use-in-universities-zero-tolerance-or-harm- reduction/.","Population Health, Clinical Audit and Specialist Care Team, NHS Digital, and Sharon Thandi. 2022. 'Psychological Therapies, Annual Report on the Use of IAPT Services, 2021-22'. Psychological Therapies, Annual Reports on the Use of IAPT Services. England: NHS. https://digital.nhs.uk/data-and-information/publications/statistical/psychological-therapies -annual-reports-on-the-use-of-iapt-services/annual-report-2021-22.","Pradel, Vincent, Catherine Delga, Frank Rouby, Joëlle Micallef, and Maryse Lapeyre-Mestre. 2010. 'Assessment of Abuse Potential of Benzodiazepines from a Prescription Database Using \"Doctor Shopping\" as an Indicator'. CNS Drugs 24: 611–20. https://doi.org/10.2165/11531570-000000000-00000.","Public Health England. 2022. 'Young People's Substance Misuse Treatment Statistics 2020 to 2021: Report'. 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Neuroscience & Biobehavioral Reviews 17 (3): 277–85. https://doi.org/10.1016/S0149-7634(05)80011-9.","Sanna, Enrico, Fabio Busonero, Giuseppe Talani, Maria Cristina Mostallino, Maria Luisa Mura, Maria Giuseppina Pisu, Elisabetta Maciocco, Mariangela Serra, and Giovanni Biggio. 2005. 'Low Tolerance and Dependence Liabilities of Etizolam: Molecular, Functional, and Pharmacological Correlates'. European Journal of Pharmacology 519 (1–2): 31–42. https://doi.org/10.1016/j.ejphar.2005.06.047.","Senay, E. C. 1990. 'Addictive Behaviors and Benzodiazepines: 2. Are There Differences between Benzodiazepines in Potential for Physical Dependence and Abuse Liability?' Advances in Alcohol & Substance Abuse 9 (3–4): 53–64.","Seppälä, T., E. Palva, M. J. Mattila, K. Korttila, and R. C. Shrotriya. 1980. 'Tofisopam, a Novel 3,4,-Benzodiazepine: Multiple-Dose Effects on Psychomotor Skills and Memory. Comparison with Diazepam and Interactions with Ethanol | SpringerLink'. Psychopharmacology 69: 209–18. https://doi.org/10.1007/BF00427652.","UN Office of Drugs and Crime. 2016. 'Terminology and Information on Drugs'. ST/NAR/51. United Nations. www.unodc.org/unodc/en/scientists/terminology-and-information-on-drugs_new.html.","Volkow, Nora. 2022. 'Addiction Often Goes Hand-in-Hand with Other Mental Illnesses. Both Must Be Addressed.' National Institutes of Health. National Institute on Drug Abuse (blog). 27 September 2022. https://nida.nih.gov/about-nida/noras-blog/2022/09/addiction-often-goes-hand-in-hand-ot her-mental-illnesses-both-must-be-addressed.","Voshaar, Richard Oude, Wim Gorgels, Audrey Mol, Anton van Balkom, Marinus Breteler, Eloy van de Lisdonk, Jan Mulder, and Frans Zitman. 2003. 'Predictors of Relapse after Discontinuation of Long-Term Benzodiazepine Use by Minimal Intervention: A 2-Year Follow-up Study'. Family Practice 20 (4): 370–72. https://doi.org/10.1093/fampra/cmg405.","Wijk, Xander M. R. van, Cassandra Yun, Shirin Hooshfar, Ann M. Arens, Derrick Lung, Alan H. B. Wu, and Kara L. Lynch. 2019. 'A Liquid-Chromatography High-Resolution Mass Spectrometry Method for Non-FDA Approved Benzodiazepines'. Journal of Analytical Toxicology 43 (4): 316–20. https://doi.org/10.1093/jat/bky092.","Zawilska, Jolanta B., and Jakub Wojcieszak. 2019. 'An Expanding World of New Psychoactive Substances—Designer Benzodiazepines'. NeuroToxicology 73 (July): 8–16. https://doi.org/10.1016/j.neuro.2019.02.015.","Zhong, GuoChao, Yi Wang, Yong Zhang, and Yong Zhao. 2015. 'Association between Benzodiazepine Use and Dementia: A Meta-Analysis'. PloS One 10 (5): e0127836. https://doi.org/10.1371/journal.pone.0127836."]}

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2022
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17. Counting on U training to enhance trusting relationships and mental health literacy among business advisors: protocol for a randomised controlled trial

Author

Saxon, Leanne, Bromfield, S, Leow-Taylor, Carol, Vega, CE, Berk, M, LaMontagne, Tony, Martin, AJ, Mohebbi, Mohammadreza, Nielsen, K, Reavley, NJ, Walker, A, Conway, A, de Silva, A, Memish, K, Rossetto, A, Tanewski, George, Noblet, Andrew, Saxon, Leanne, Bromfield, S, Leow-Taylor, Carol, Vega, CE, Berk, M, LaMontagne, Tony, Martin, AJ, Mohebbi, Mohammadreza, Nielsen, K, Reavley, NJ, Walker, A, Conway, A, de Silva, A, Memish, K, Rossetto, A, Tanewski, George, and Noblet, Andrew

Abstract

Background: Financial distress is thought to be a key reason why small-medium enterprise (SME) owners experience higher levels of mental health conditions compared with the broader population. Business advisors who form trusting, high-quality relationships with their SME clients, are therefore well placed to: (1) help prevent/reduce key sources of financial distress, (2) better understand the business and personal needs of their clients and, (3) recognise the signs and symptoms of mental health conditions and encourage help-seeking where appropriate. The aim of this study is to compare the effectiveness of relationship building training (RBT) combined with mental health first aid (MHFA) training for business advisors with MHFA alone, on the financial and mental health of their SME-owner clients. Methods: This is a single blind, two-arm randomised controlled trial. Participants will be business advisors who provide information, guidance and/or assistance to SME owner clients and are in contact with them at least 3 times a year. The business advisors will invite their SME-owner clients to complete 3 online surveys at baseline, 6- and 12-months. Business advisors will be randomised to one of two conditions, using a 1:1 allocation ratio: (1) MHFA with RBT; or (2) MHFA alone, and complete 3 online surveys at baseline, 2- and 6-months. Primary outcomes will be measured in the business advisors and consist of the quality of the relationship, stigmatizing attitude, confidence to offer mental health first aid, quality of life and provision of mental health first aid. Secondary outcomes will be measured in the SME owners and includes trust in their business advisors, the quality of this relationship, financial wellbeing, financial distress, psychological distress, help-seeking behaviour, and quality of life. To complement the quantitative data, we will include a qualitative process evaluation to examine what contextual factors impacted the reach, effectiveness, adoption, impl

Published
2022

18. 177Lu-PSMA-617 and Idronoxil in Men with End-Stage Metastatic Castration-Resistant Prostate Cancer (LuPIN) Patient Outcomes and Predictors of Treatment Response in a Phase I/II Trial

Author

Pathmanandavel, S, Crumbaker, M, Yam, AO, Nguyen, A, Rofe, C, Hovey, E, Gedye, C, Kwan, EM, Hauser, C, Azad, AA, Eu, P, Martin, AJ, Joshua, AM, Emmett, L, Pathmanandavel, S, Crumbaker, M, Yam, AO, Nguyen, A, Rofe, C, Hovey, E, Gedye, C, Kwan, EM, Hauser, C, Azad, AA, Eu, P, Martin, AJ, Joshua, AM, and Emmett, L

Abstract

177Lu-PSMA-617 is an effective therapy for metastatic castration-resistant prostate cancer (mCRPC). However, treatment resistance occurs frequently, and combination therapies may improve outcomes. We report the final safety and efficacy results of a phase I/II study combining 177Lu-PSMA-617 with idronoxil (NOX66), a radiosensitizer, and examine potential clinical, blood-based, and imaging biomarkers. Methods: Fifty-six men with progressive mCRPC previously treated with taxane chemotherapy and novel androgen signaling inhibitor (ASI) were enrolled. Patients received up to 6 doses of 177Lu-PSMA-617 (7.5 GBq) on day 1 in combination with a NOX66 suppository on days 1-10 of each 6-wk cycle. Cohort 1 (n = 8) received 400 mg of NOX66, cohort 2 (n = 24) received 800 mg, and cohort 3 (n = 24) received 1,200 mg. 68Ga-PSMA and 18F-FDG PET/CT were performed at study entry, and semiquantitative imaging analysis was undertaken. Blood samples were collected for analysis of blood-based biomarkers, including androgen receptor splice variant 7 expression. The primary outcomes were safety and tolerability; secondary outcomes included efficacy, pain scores, and xerostomia. Regression analyses were performed to explore the prognostic value of baseline clinical, blood-based, and imaging parameters. Results: Fifty-six of the 100 men screened were enrolled (56%), with a screening failure rate of 26% (26/100) for PET imaging criteria. All men had received prior treatment with ASI and docetaxel, and 95% (53/56) had received cabazitaxel. Ninety-six percent (54/56) of patients received at least 2 cycles of combination NOX66 and 177Lu-PSMA-617, and 46% (26/56) completed 6 cycles. Common adverse events were anemia, fatigue, and xerostomia. Anal irritation attributable to NOX66 occurred in 38%. Forty-eight of 56 had a reduction in prostate-specific antigen (PSA) level (86%; 95% CI, 74%-94%); 34 of 56 (61%; 95% CI, 47%-74%) had a PSA reduction of at least 50%. Median PSA progression-free survival

Published
2022

19. Health-Related Quality of Life in Metastatic, Hormone-Sensitive Prostate Cancer: ENZAMET (ANZUP 1304), an International, Randomized Phase III Trial Led by ANZUP

Author

Stockler, MR, Martin, AJ, Davis, ID, Dhillon, HM, Begbie, SD, Chi, KN, Chowdhury, S, Coskinas, X, Frydenberg, M, Hague, WE, Horvath, LG, Joshua, AM, Lawrence, NJ, Marx, GM, McCaffrey, J, McDermott, R, McJannett, M, North, SA, Parnis, F, Parulekar, WR, Pook, DW, Reaume, MN, Sandhu, S, Tan, A, Tan, TH, Thomson, A, Vera-Badillo, F, Williams, SG, Winter, DG, Yip, S, Zhang, AY, Zielinski, RR, Sweeney, CJ, Stockler, MR, Martin, AJ, Davis, ID, Dhillon, HM, Begbie, SD, Chi, KN, Chowdhury, S, Coskinas, X, Frydenberg, M, Hague, WE, Horvath, LG, Joshua, AM, Lawrence, NJ, Marx, GM, McCaffrey, J, McDermott, R, McJannett, M, North, SA, Parnis, F, Parulekar, WR, Pook, DW, Reaume, MN, Sandhu, S, Tan, A, Tan, TH, Thomson, A, Vera-Badillo, F, Williams, SG, Winter, DG, Yip, S, Zhang, AY, Zielinski, RR, and Sweeney, CJ

Abstract

PURPOSE: We previously reported that enzalutamide improved overall survival when added to standard of care in metastatic, hormone-sensitive prostate cancer. Here, we report its effects on aspects of health-related quality of life (HRQL). METHODS: HRQL was assessed with the European Organisation for Research and Treatment of Cancer core quality-of-life questionnaire and QLM-PR25 at weeks 0, 4, 12, and then every 12 weeks until progression. Scores from week 4 to 156 were analyzed with repeated measures modeling to calculate group means and differences. Deterioration-free survival was from random assignment until the earliest of death, clinical progression, discontinuation of study treatment, or a worsening of 10 points or more from baseline in fatigue, physical function, cognitive function, or overall health and quality of life (OHQL). HRQL scores range from 0 (lowest possible) to 100 (highest possible). RESULTS: HRQL was assessed in 1,042 of 1,125 participants (93%). Differences in means favored control over enzalutamide for fatigue (5.2, 95% CI, 3.6 to 6.9; P < .001), cognitive function (4.0, 95% CI, 2.5 to 5.5; P < .001), and physical function (2.6, 95% CI, 1.3 to 3.9; P < .001), but not OHQL (1.2, 95% CI, -0.2 to 2.7; P = .1). Deterioration-free survival rates at 3 years, and log-rank P values comparing the whole distributions, favored enzalutamide over control for OHQL (31% v 17%; P < .0001), cognitive function (31% v 20%; P = .001), and physical function (31% v 22%; P < .001), but not fatigue (24% v 18%; P = .16). The effects of enzalutamide on HRQL were independent of baseline characteristics. CONCLUSION: Enzalutamide was associated with worsening of self-reported fatigue, cognitive function, and physical function, but not OHQL. Enzalutamide was associated with improved deterioration-free survival for OHQL, physical function, and cognitive function because delays in disease progression outweighed early deteriorations in these aspects of HRQL.

Published
2022

20. 'Pain-free TRUS B': a phase 3 double-blind placebo-controlled randomized trial of methoxyflurane with periprostatic local anaesthesia to reduce the discomfort of transrectal ultrasonography-guided prostate biopsy (ANZUP 1501)

Author

Hayne, D, Grummet, J, Espinoza, D, McCombie, SP, Chalasani, V, Ford, KS, Frydenberg, M, Gilling, P, Gordon, B, Hawks, C, Konstantatos, A, Martin, AJ, Nixon, A, O'Brien, C, Patel, M, Sengupta, S, Shahbaz, S, Subramaniam, S, Williams, S, Woo, HH, Stockler, MR, Davis, ID, Buchan, N, Hayne, D, Grummet, J, Espinoza, D, McCombie, SP, Chalasani, V, Ford, KS, Frydenberg, M, Gilling, P, Gordon, B, Hawks, C, Konstantatos, A, Martin, AJ, Nixon, A, O'Brien, C, Patel, M, Sengupta, S, Shahbaz, S, Subramaniam, S, Williams, S, Woo, HH, Stockler, MR, Davis, ID, and Buchan, N

Abstract

OBJECTIVE: To determine whether the addition of inhaled methoxyflurane to periprostatic infiltration of local anaesthetic (PILA) during transrectal ultrasonography-guided prostate biopsies (TRUSBs) improved pain and other aspects of the experience. PATIENTS AND METHODS: We conducted a multicentre, placebo-controlled, double-blind, randomized phase 3 trial, involving 420 men undergoing their first TRUSB. The intervention was PILA plus a patient-controlled device containing either 3 mL methoxyflurane, or 3 mL 0.9% saline plus one drop of methoxyflurane to preserve blinding. The primary outcome was the pain score (0-10) reported by the participant after 15 min. Secondary outcomes included ratings of other aspects of the biopsy experience, willingness to undergo future biopsies, urologists' ratings, biopsy completion, and adverse events. RESULTS: The mean (SE) pain scores 15 min after TRUSB were 2.51 (0.22) in those assigned methoxyflurane vs 2.82 (0.22) for placebo (difference 0.31, 95% confidence interval [CI] -0.75 to 0.14; P = 0.18). Methoxyflurane was associated with better scores for discomfort (difference -0.48, 95% CI -0.92 to -0.03; P = 0.035, adjusted [adj.] P = 0.076), whole experience (difference -0.50, 95% CI -0.92 to -0.08; P = 0.021, adj. P = 0.053), and willingness to undergo repeat biopsies (odds ratio 1.67, 95% CI 1.12-2.49; P = 0.01) than placebo. Methoxyflurane resulted in higher scores for drowsiness (difference +1.64, 95% CI 1.21-2.07; P < 0.001, adj. P < 0.001) and dizziness (difference +1.78, 95% CI 1.31-2.24; P < 0.001, adj. P < 0.001) than placebo. There was no significant difference in the number of ≥ grade 3 adverse events. CONCLUSIONS: We found no evidence that methoxyflurane improved pain scores at 15 min, however, improvements were seen in patient-reported discomfort, overall experience, and willingness to undergo repeat biopsies.

Published
2022

21. Counting on U training to enhance trusting relationships and mental health literacy among business advisors: protocol for a randomised controlled trial

Author

Saxon, L, Bromfield, S, Leow-Taylor, SH, Vega, CE, Berk, M, LaMontagne, AD, Martin, AJ, Mohebbi, M, Nielsen, K, Reavley, NJ, Walker, A, Conway, A, de Silva, A, Memish, K, Rossetto, A, Tanewski, G, Noblet, A, Saxon, L, Bromfield, S, Leow-Taylor, SH, Vega, CE, Berk, M, LaMontagne, AD, Martin, AJ, Mohebbi, M, Nielsen, K, Reavley, NJ, Walker, A, Conway, A, de Silva, A, Memish, K, Rossetto, A, Tanewski, G, and Noblet, A

Abstract

BACKGROUND: Financial distress is thought to be a key reason why small-medium enterprise (SME) owners experience higher levels of mental health conditions compared with the broader population. Business advisors who form trusting, high-quality relationships with their SME clients, are therefore well placed to: (1) help prevent/reduce key sources of financial distress, (2) better understand the business and personal needs of their clients and, (3) recognise the signs and symptoms of mental health conditions and encourage help-seeking where appropriate. The aim of this study is to compare the effectiveness of relationship building training (RBT) combined with mental health first aid (MHFA) training for business advisors with MHFA alone, on the financial and mental health of their SME-owner clients. METHODS: This is a single blind, two-arm randomised controlled trial. Participants will be business advisors who provide information, guidance and/or assistance to SME owner clients and are in contact with them at least 3 times a year. The business advisors will invite their SME-owner clients to complete 3 online surveys at baseline, 6- and 12-months. Business advisors will be randomised to one of two conditions, using a 1:1 allocation ratio: (1) MHFA with RBT; or (2) MHFA alone, and complete 3 online surveys at baseline, 2- and 6-months. Primary outcomes will be measured in the business advisors and consist of the quality of the relationship, stigmatizing attitude, confidence to offer mental health first aid, quality of life and provision of mental health first aid. Secondary outcomes will be measured in the SME owners and includes trust in their business advisors, the quality of this relationship, financial wellbeing, financial distress, psychological distress, help-seeking behaviour, and quality of life. To complement the quantitative data, we will include a qualitative process evaluation to examine what contextual factors impacted the reach, effectiveness, adoption, impl

Published
2022

22. Overview of JET results for optimising ITER operation

Author

Mailloux, J, Abid, N, Abraham, K, Abreu, P, Adabonyan, O, Adrich, P, Afanasev, V, Afzal, M, Ahlgren, T, Aho-Mantila, L, Aiba, N, Airila, M, Akhtar, M, Albanese, R, Alderson-Martin, M, Alegre, D, Aleiferis, S, Aleksa, A, Alekseev, A, Alessi, E, Aleynikov, P, Algualcil, J, Ali, M, Allinson, M, Alper, B, Alves, E, Ambrosino, G, Ambrosino, R, Amosov, V, Sunden, E, Andrew, P, Angelini, B, Angioni, C, Antoniou, I, Appel, L, Appelbee, C, Aria, S, Ariola, M, Artaserse, G, Arter, W, Artigues, V, Asakura, N, Ash, A, Ashikawa, N, Aslanyan, V, Astrain, M, Asztalos, O, Auld, D, Auriemma, F, Austin, Y, Avotina, L, Aymerich, E, Baciero, A, Bairaktaris, F, Balbin, J, Balbinot, L, Balboa, I, Balden, M, Balshaw, C, Balshaw, N, Bandaru, V, Banks, J, Baranov, Y, Barcellona, C, Barnard, A, Barnard, M, Barnsley, R, Barth, A, Baruzzo, M, Barwell, S, Bassan, M, Batista, A, Batistoni, P, Baumane, L, Bauvir, B, Baylor, L, Beaumont, P, Beckett, D, Begolli, A, Beidler, M, Bekris, N, Beldishevski, M, Belli, E, Belli, F, Belonohy, E, Ben Yaala, M, Benayas, J, Bentley, J, Bergsaker, H, Bernardo, J, Bernert, M, Berry, M, Bertalot, L, Betar, H, Beurskens, M, Bickerton, S, Bieg, B, Bielecki, J, Bierwage, A, Biewer, T, Bilato, R, Bilkova, P, Birkenmeier, G, Bishop, H, Bizarro, J, Blackburn, J, Blanchard, P, Blatchford, P, Bobkov, V, Boboc, A, Bohm, P, Bohm, T, Bolshakova, I, Bolzonella, T, Bonanomi, N, Bonfiglio, D, Bonnin, X, Bonofiglo, P, Boocock, S, Booth, A, Booth, J, Borba, D, Borodin, D, Borodkina, I, Boulbe, C, Bourdelle, C, Bowden, M, Boyd, K, Mihalic, I, Bradnam, S, Braic, V, Brandt, L, Bravanec, R, Breizman, B, Brett, A, Brezinsek, S, Brix, M, Bromley, K, Brown, B, Brunetti, D, Buckingham, R, Buckley, M, Budny, R, Buermans, J, Bufferand, H, Buratti, P, Burgess, A, Buscarino, A, Busse, A, Butcher, D, de la Cal, E, Calabro, G, Calacci, L, Calado, R, Camenen, Y, Canal, G, Cannas, B, Cappelli, M, Carcangiu, S, Card, P, Cardinali, A, Carman, P, Carnevale, D, Carr, M, Carralero, D, Carraro, L, Carvalho, I, Carvalho, P, Casiraghi, I, Casson, F, Castaldo, C, Catalan, J, Catarino, N, Causa, F, Cavedon, M, Cecconello, M, Challis, C, Chamberlain, B, Chang, C, Chankin, A, Chapman, B, Chernyshova, M, Chiariello, A, Chmielewski, P, Chomiczewska, A, Chone, L, Ciraolo, G, Ciric, D, Clark, M, Clarkson, R, Clements, C, Cleverly, M, Coad, J, Coates, P, Cobalt, A, Coccorese, V, Coelho, R, Coenen, J, Coffey, I, Colangeli, A, Colas, L, Collins, C, Collins, J, Collins, S, Conka, D, Conroy, S, Conway, B, Conway, N, Coombs, D, Cooper, P, Cooper, S, Corradino, C, Corrigan, G, Coster, D, Cox, P, Craciunescu, T, Cramp, S, Crapper, C, Craven, D, Craven, R, Esposito, M, Croci, G, Croft, D, Croitoru, A, Crombe, K, Cronin, T, Cruz, N, Crystal, C, Cseh, G, Cufar, A, Cullen, A, Curuia, M, Czarski, T, Dabirikhah, H, Dal Molin, A, Dale, E, Dalgliesh, P, Dalley, S, Dankowski, J, David, P, Davies, A, Davies, S, Davis, G, Dawson, K, Dawson, S, Day, I, De Bock, M, De Temmerman, G, De Tommasi, G, Deakin, K, Deane, J, Dejarnac, R, Del Sarto, D, Delabie, E, Del-Castillo-Negrete, D, Dempsey, A, Dendy, R, Devynck, P, Di Siena, A, Di Troia, C, Dickson, T, Dinca, P, Dittmar, T, Dobrashian, J, Doerner, R, Donne, A, Dorling, S, Dormido-Canto, S, Douai, D, Dowson, S, Doyle, R, Dreval, M, Drewelow, P, Drews, P, Drummond, G, Duckworth, P, Dudding, H, Dumont, R, Dumortier, P, Dunai, D, Dunatov, T, Dunne, M, Durodie, F, Dux, R, Dvornova, A, Eastham, R, Edwards, J, Eich, T, Eichorn, A, Eidietis, N, Eksaeva, A, El Haroun, H, Ellwood, G, Elsmore, C, Embreus, O, Emery, S, Ericsson, G, Eriksson, B, Eriksson, F, Eriksson, J, Eriksson, L, Ertmer, S, Esquembri, S, Esquisabel, A, Estrada, T, Evans, G, Evans, S, Fable, E, Fagan, D, Faitsch, M, Falessi, M, Fanni, A, Farahani, A, Farquhar, I, Fasoli, A, Faugeras, B, Fazinic, S, Felici, F, Felton, R, Fernandes, A, Fernandes, H, Ferrand, J, Ferreira, D, Ferreira, J, Ferro, G, Fessey, J, Ficker, O, Field, A, Figueiredo, A, Figueiredo, J, Fil, A, Fil, N, Finburg, P, 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AP, van de Plassche, KL, Poli, FM, Pompilian, OG, Porfiri, MT, Rasmussen, JJ, Richiusa, ML, Rimini, FG, Roach, CM, Ramos, MR, Ruiz, JR, Schneider, PA, Sharapov, SE, Silburn, SA, Sipila, SK, Sips, ACC, Solano, ER, Strauss, HR, Stuart, CI, Sun, HJ, Susts, TE, Teimane, AS, Tinguely, RA, Turner, MM, Olivares, PV, Rinati, GV, Virtanen, AJ, Walkden, NR, Maxwell, HW, Williams, JC, Wright, JC, Zabolockis, RJ, Zaitsev, FS, Fernandez, DZ, Zastrow, KD, and Zotta, VK

Abstract

The JET 2019-2020 scientific and technological programme exploited the results of years of concerted scientific and engineering work, including the ITER-like wall (ILW: Be wall and W divertor) installed in 2010, improved diagnostic capabilities now fully available, a major neutral beam injection upgrade providing record power in 2019-2020, and tested the technical and procedural preparation for safe operation with tritium. Research along three complementary axes yielded a wealth of new results. Firstly, the JET plasma programme delivered scenarios suitable for high fusion power and alpha particle (alpha) physics in the coming D-T campaign (DTE2), with record sustained neutron rates, as well as plasmas for clarifying the impact of isotope mass on plasma core, edge and plasma-wall interactions, and for ITER pre-fusion power operation. The efficacy of the newly installed shattered pellet injector for mitigating disruption forces and runaway electrons was demonstrated. Secondly, research on the consequences of long-term exposure to JET-ILW plasma was completed, with emphasis on wall damage and fuel retention, and with analyses of wall materials and dust particles that will help validate assumptions and codes for design and operation of ITER and DEMO. Thirdly, the nuclear technology programme aiming to deliver maximum technological return from operations in D, T and D-T benefited from the highest D-D neutron yield in years, securing results for validating radiation transport and activation codes, and nuclear data for ITER.

Published
2022

23. The 'ins and outs' of student engagement in mathematics: shifts in engagement factors among high and low achievers

Author

Skilling, K, Bobis, J, and Martin, AJ

Subjects
General Mathematics, media_common.quotation_subject, education, 05 social sciences, 050301 education, Student engagement, Questionnaire data, Education, Interview data, Achievement level, Feeling, Low achievers, Mathematics education, 0501 psychology and cognitive sciences, Disengagement theory, 0503 education, 050104 developmental & child psychology, media_common
Abstract

Student engagement in mathematics in the early secondary years can be fragile. Engagement in learning fluctuates in response to students’ mathematics experiences and is underpinned by numerous adaptive and maladaptive factors. Thirty-seven 11–12 year old students (grades 6–7) responded twice to a questionnaire to measure shifts in their engagement and motivation over a 1-year period as they transitioned from primary to secondary school. When plotted on spider graphs, the results of specific adaptive and maladaptive factors visually demonstrate “in and out” movements as students’ engagement levels shifted from time 1 to time 2. Subsequent semistructured interviews complemented questionnaire data by eliciting student beliefs about their achievement, feelings and behaviours towards mathematics. Interview data shed light on the reasons for individual student shifts in motivation and engagement during the transition. Together, data reveal four unique engagement/achievement characteristics. Significantly, students who were more alike in terms of their engagement reported similar factor patterns regardless of their achievement level. Findings draw attention to the importance of addressing mathematics engagement for students of all achievement levels.

Published
2020

24. Platelet-Rich Plasma Versus Autologous Fat Graft for Chronic Wound Management in Low-Resource Settings: A Single-Center Pilot Randomized Controlled Trial

Author

Martin Ajujo, Stanley Khainga, Ferdinand Nangole, Daniel Zuriel, and Thomas Amuti

Subjects
platelet-rich plasma, autologous fat grafting, chronic wound healing, granulation, Surgery, RD1-811
Abstract

Background: Autologous fat grafts (AFGs) and platelet-rich plasmas (PRPs) are useful adjuncts to healing of chronic wounds. In the resource-limited setting, PRP is the more attractive option owing to its ease of use. There is, however, a paucity of data comparing the two. Methods: In this single-center randomized controlled trial, we recruited 56 participants in the AFG (26) and PRP (30) groups. Bed preparation and standard dressings were done, then AFGs or PRPs were injected at the wound base and peri-wound area. On days 3, 7, 14, 21, and 28 data for epithelialization, granulation, wound contraction, pain, and infections were collected and analyzed using SPSS. Results: Granulation and epithelialization increased from day 0 to 28 in both groups with statistical differences observed on days 0, 14, and 21 (p values = 0.033, 0.002, and 0.002, respectively, for granulation and no significant difference noted for epithelialization). Contraction was observed in both groups from day 0 to 28 with a significant difference noted on days 3 and 7 (p value = 0.015 and 0.004, respectively). Pain decreased from day 0 to 28, with the PRP group recording lower values. There were no infections among the AFG group, while in the PRP group, infections were reported on day 3. Conclusions: PRP provides a viable option over fat graft in the management of chronic wounds.

Published
2024
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25. A Multilevel Person-Centered Examination of Teachers' Workplace Experiences: Replication and Extension With Links to Instructional Support and Achievement

Author

Collie, RJ, Martin, AJ, Morin, AJS, Malmberg, LE, Sammons, P, Collie, RJ, Martin, AJ, Morin, AJS, Malmberg, LE, and Sammons, P

Abstract

In a replication and extension of an earlier study, we relied on person-centered analyses to identify teacher (Level 1) and school (Level 2) profiles based on teachers' experiences of job demands (barriers to professional development, disruptive student behavior), job resources (teacher collaboration, input in decision-making), and personal resources (self-efficacy). We examined data from 5,439 teachers working in 364 schools in Australia and 2,216 teachers working in 149 schools in England. Latent profile analysis revealed six teacher profiles: Low-Demand-Flourisher (11%), Mixed-Demand-Flourisher (17%), Job-Resourced-Average (11%), Balanced-Average (14%), Mixed-Resourced-Struggler (11%), and Low-Resourced-Struggler (36%). Two school profiles were identified: an Unsupportive school profile (43%) and a Supportive school profile (57%). Several significant relations between these profiles and teacher/school characteristics and work-related outcomes were also identified at both levels. Although our results generally replicated prior findings, some differences were also observed, possibly as a results of recent changes in policies regarding in teacher support and accountability. Next, we extended prior work using a subsample of the Australian teachers for whom we had matching student data. This second set of results revealed that schools with a greater proportion of low-SES students were more likely to present an Unsupportive school profile. Moreover, the Supportive school profile was associated with higher levels of student-reported instructional support and school-average achievement in reading, mathematics, and science.

Published
2021

26. The role of mobile technology in promoting social inclusion among adults with intellectual disabilities

Author

Martin, AJ, Strnadová, I, Loblinzk, J, Danker, JC, Cumming, TM, Martin, AJ, Strnadová, I, Loblinzk, J, Danker, JC, and Cumming, TM

Abstract

Background: Mobile technology has the potential to assist adults with intellectual disabilities to initiate and maintain social connections in important areas of their lives, such as family, friends and work/volunteering. Method: The present study investigated how specific aspects of mobile device/app use are associated with the social inclusion of people with intellectual disabilities. The study also examined what background attributes were associated with particular patterns of mobile device/app use and social inclusion. Results: The findings revealed that the use of mobile technology among adults with intellectual disabilities was positively associated with their social inclusion with family, friends and work/volunteering. There were also some key background attributes associated with participants’ use of mobile technology and the extent to which mobile technology assisted their social inclusion. Conclusions: Implications for practice and policy are discussed.

Published
2021

27. A cluster RCT to improve workplace mental health in a policing context: Findings of a mixed-methods implementation evaluation

Author

LaMontagne, AD, Martin, AJ, Page, KM, Papas, A, Reavley, NJ, Noblet, AJ, Milner, AJ, Keegel, T, Allisey, A, Witt, K, Smith, PM, LaMontagne, AD, Martin, AJ, Page, KM, Papas, A, Reavley, NJ, Noblet, AJ, Milner, AJ, Keegel, T, Allisey, A, Witt, K, and Smith, PM

Abstract

BACKGROUND: We conducted a cluster randomized trial of a workplace mental health intervention in an Australian police department. The intervention was co-designed and co-implemented with the police department. Intervention elements included tailored mental health literacy training for all members of participating police stations, and a leadership development and coaching program for station leaders. This study presents the results of a mixed-methods implementation evaluation of the trial. METHODS: Descriptive quantitative analyses characterized the extent of participation in intervention activities, complemented by a qualitative descriptive analysis of transcripts of 60 semistructured interviews with 53 persons and research team field notes. RESULTS: Participation rates in the multicomponent leadership development activities were highly variable, ranging from <10% to approximately 60% across stations. Approximately 50% of leaders and <50% of troops completed the mental health literacy training component of the intervention. Barriers to implementation included rostering challenges, high staff turnover and changes, competing work commitments, staff shortages, limited internal personnel resources to deliver the mental health literacy training, organizational cynicism, confidentiality concerns, and limited communication about the intervention by station command or station champions. Facilitators of participation were also identified, including perceived need for and benefits of the intervention, engagement at various levels, the research team's ability to create buy-in and manage stakeholder relationships, and the use of external, credible leadership development coaches. CONCLUSIONS: Implementation fell far short of expectations. The identified barriers and facilitators should be considered in the design and implementation of similar workplace mental health interventions.

Published
2021

28. Rate of Antibiotic Use and Associated Risk Factors in COVID-19 Hospitalized Patients

Author

Kelly E Pillinger, Martin Aj, Katelyn Quartuccio, Stephanie Shulder, and David M Dobrzynski

Subjects
Mechanical ventilation, ARDS, medicine.medical_specialty, Univariate analysis, Coronavirus disease 2019 (COVID-19), Hospitalized patients, business.industry, medicine.drug_class, medicine.medical_treatment, Antibiotics, medicine.disease, Internal medicine, Clinical endpoint, medicine, Observational study, business
Abstract

BackgroundLiterature suggests that antibiotic prescribing in COVID-19 patients is high, despite low rates of confirmed bacterial infection. There are little data on what drives prescribing habits.ObjectiveThis study sought to determine antibiotic prescribing rates and risk factors for antibiotic prescribing in hospitalized patients. It was the first study to assess risk factors for receiving more than one course of antibiotics.MethodsThis was a retrospective, multi-center, observational study. Patients admitted from March 1, 2020 to May 31, 2020 and treated for PCR-confirmed COVID-19 were included. The primary endpoint was the rate of antibiotic use during hospitalization. Secondary endpoints included risk factors associated with antibiotic use, risk factors associated with receiving more than one antibiotic course, and rate of microbiologically confirmed infections.ResultsA total of 208 encounters (198 patients) were included in the final analysis. Eighty-three percent of patients received at least one course of antibiotics, despite low rates of microbiologically confirmed infection (12%). Almost one-third of patients (30%) received more than one course of antibiotics. Risk factors identified for both antibiotic prescribing and receiving more than one course of antibiotics were more serious illness, increased hospital length of stay, intensive care unit admission, mechanical ventilation, and acute respiratory distress syndrome.Conclusion and relevanceThere were high rates of antibiotic prescribing with low rates of bacterial co-infection. Many patients received more than one course of antibiotics during hospitalization. This study highlights the need for increased antibiotic stewardship practices in COVID-19 patients.

Published
2020

29. An engineered pathway for glyoxylate metabolism in tobacco plants aimed to avoid the release of ammonia in photorespiration

Author

Carvalho Josirley de FC, Madgwick Pippa J, Powers Stephen J, Keys Alfred J, Lea Peter J, and Parry Martin AJ

Subjects
Biotechnology, TP248.13-248.65
Abstract

Abstract Background The photorespiratory nitrogen cycle in C3 plants involves an extensive diversion of carbon and nitrogen away from the direct pathways of assimilation. The liberated ammonia is re-assimilated, but up to 25% of the carbon may be released into the atmosphere as CO2. Because of the loss of CO2 and high energy costs, there has been considerable interest in attempts to decrease the flux through the cycle in C3 plants. Transgenic tobacco plants were generated that contained the genes gcl and hyi from E. coli encoding glyoxylate carboligase (EC 4.1.1.47) and hydroxypyruvate isomerase (EC 5.3.1.22) respectively, targeted to the peroxisomes. It was presumed that the two enzymes could work together and compete with the aminotransferases that convert glyoxylate to glycine, thus avoiding ammonia production in the photorespiratory nitrogen cycle. Results When grown in ambient air, but not in elevated CO2, the transgenic tobacco lines had a distinctive phenotype of necrotic lesions on the leaves. Three of the six lines chosen for a detailed study contained single copies of the gcl gene, two contained single copies of both the gcl and hyi genes and one line contained multiple copies of both gcl and hyi genes. The gcl protein was detected in the five transgenic lines containing single copies of the gcl gene but hyi protein was not detected in any of the transgenic lines. The content of soluble amino acids including glycine and serine, was generally increased in the transgenic lines growing in air, when compared to the wild type. The content of soluble sugars, glucose, fructose and sucrose in the shoot was decreased in transgenic lines growing in air, consistent with decreased carbon assimilation. Conclusions Tobacco plants have been generated that produce bacterial glyoxylate carboligase but not hydroxypyruvate isomerase. The transgenic plants exhibit a stress response when exposed to air, suggesting that some glyoxylate is diverted away from conversion to glycine in a deleterious short-circuit of the photorespiratory nitrogen cycle. This diversion in metabolism gave rise to increased concentrations of amino acids, in particular glutamine and asparagine in the leaves and a decrease of soluble sugars.

Published
2011
Full Text
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31. Adaptability, engagement, and degree completion: a longitudinal investigation of university students*

Author

Holliman, AJ, Martin, AJ, Collie, RJ, Holliman, AJ, Martin, AJ, and Collie, RJ

Abstract

© 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group. University entry and the passage through university is a time of great change. The extent to which students are able to adjust to successfully navigate this change (adaptability) is likely to influence their academic outcomes. Prior research has identified a link between university students’ adaptability and academic achievement via behavioural engagement. The current longitudinal study extends this research by examining whether university students’ adaptability predicts degree completion via behavioural engagement. Undergraduate students (N = 186) were surveyed for their adaptability and behavioural engagement at degree commencement. Their completion status was extracted from the University Records System at the end of the degree. Findings showed that adaptability predicts both positive and negative behavioural engagement, and that negative (but not positive) behavioural engagement predicts degree completion. Adaptability was also found to influence degree completion indirectly via negative behavioural engagement. These findings hold important theoretical and practical implications for educators and researchers seeking to understand how students manage the transition to university and the extent to, and mechanisms by which students’ adaptability is associated with university degree completion.

Published
2018

32. Neonatal morbidity at term, early child development, and school performance: A population study

Author

Bentley, JP, Schneuer, FJ, Lain, SJ, Martin, AJ, Gordon, A, Nassar, N, Bentley, JP, Schneuer, FJ, Lain, SJ, Martin, AJ, Gordon, A, and Nassar, N

Abstract

OBJECTIVES: Investigate the association between severe neonatal morbidity (SNM) and child development and school performance among term infants. METHODS: The study population included term infants without major congenital conditions born between 2000 and 2007 in New South Wales, Australia, with a linked record of developmental assessment at ages 4 to 6 years in 2009 or 2012 (n = 144 535) or school performance at ages 7 to 9 years from 2009 to 2014 (n = 253 447). Developmental outcomes included special needs or being vulnerable and/or at risk in 1 of 5 developmental domains. School performance outcomes were test exemption, or performing <-1 SD on reading or numeracy tests. Binary generalized estimating equations were used to estimate associations between SNM and outcomes, adjusting for sociodemographic, perinatal, and assessment and/or test characteristics. RESULTS: Overall, 2.1% of infants experienced SNM. The adjusted odds ratio (95% confidence interval) for SNM and physical health was 1.18 (1.08-1.29), 1.14 (1.02-1.26) for language and cognitive skills, and 1.14 (1.06-1.24) and 1.13 (1.05-1.21) for scoring <-1 SD in reading and numeracy, respectively. SNM was most strongly associated with special needs 1.34 (1.15-1.55) and test exemption 1.50 (1.25-1.81). SNM infants born at 37 to 38 weeks' gestation and who were small for gestational age had the greatest likelihood of poorer outcomes. CONCLUSIONS: Term infants with SNM have greater odds of poor neurodevelopment in childhood. These findings provide population-based information for families and can inform clinical counseling and guidelines for follow-up and early intervention.

Published
2018

33. Adaptability, personal best (PB) goals setting, and gains in students’ academic outcomes: A longitudinal examination from a social cognitive perspective

Author

Burns, EC, Martin, AJ, Collie, RJ, Burns, EC, Martin, AJ, and Collie, RJ

Abstract

© 2018 Elsevier Inc. The present investigation examines how two novel constructs, adaptability (for self-regulation) and PB goal setting (for goal setting), operate alongside the more “traditional” constructs of the triadic model of social cognitive theory (SCT; Bandura, 1986) to predict students’ academic gains over time. Given that the triadic model highlights the importance of self-regulation and goal setting in human motivation, it is important to revisit classic models (such as SCT) to ascertain the role and validity of these new and relevant constructs in seminal conceptualizing. A longitudinal process model explored the extent to which: social support from parents, peers, and teachers (environmental factors) predicted gains in students’ self-efficacy, perceived control, adaptability, and PB goal setting (personal factors); self-efficacy, perceived control, and adaptability predicted growth in students’ PB goal setting; and, PB goal setting predicted academic growth in engagement and achievement (behavioral factors). Data were collected via survey one year apart across the 2014 and 2015 academic years from N = 1481 students in nine Australian high schools. Longitudinal structural equation modelling indicated that parent, peer, and teacher social support significantly predicted gains in adaptability and self-efficacy; adaptability, self-efficacy, and teacher support significantly predicted gains in PB goal setting; and PB goal setting significantly predicted gains in both academic engagement and achievement. These findings extend and augment previous work by providing support for the positive role adaptability and PB goal setting play in student academic functioning over time. Similarly, this investigation confirms the viability of including adaptability and PB goal setting within SCT's triadic model and provides evidence for their impact within the larger psycho-educational terrain.

Published
2018

34. Social and Emotional Behavioral Profiles in Kindergarten: A Population-Based Latent Profile Analysis of Links to Socio-Educational Characteristics and Later Achievement

Author

Collie, RJ, Martin, AJ, Nassar, N, Roberts, CL, Collie, RJ, Martin, AJ, Nassar, N, and Roberts, CL

Abstract

Relatively little attention has been given to understanding different social and emotional behavior (SEB) profiles among students and their links to important educational outcomes. We applied latent profile analysis to identify SEB profiles among kindergarten students based on five SEBs: cooperative, socially responsible, helpful, anxious, and aggressive-disruptive behavior. In Study 1, we identified SEB profiles among the population of students who attended kindergarten in New South Wales (NSW; Australia's most populous state comprising Australia's largest education jurisdictions), Australia in 2012 (N = 100,776). We also examined whether profile membership was differentially associated with students' socioeducational characteristics (gender, age group, language background, neighborhood socioeconomic status, and learning disability status). Results revealed four different SEB profiles: social-emotional prosocial (SE-Prosocial), SE-Anxious, SE-Aggressive, and SE-Vulnerable groups. Profile membership was associated with the socioeducational characteristics in different ways (e.g., female and older students tended to be in the SE-Prosocial profile). In Study 2, we undertook replication with a different sample of children who attended kindergarten in 2009 in NSW (n = 52,661). We also examined whether the SEB profiles were associated with academic achievement in Grades 3 and 5 using standardized test scores. Results revealed the same four profiles as Study 1 and similarities in how profile membership was associated with the socioeducational characteristics. Moreover, profiles were associated with significantly different levels of achievement in Grades 3 and 5-highest for the SE-Prosocial and lowest for the SE-Vulnerable profiles. Together, the findings have implications for healthy student development and academic intervention.

Published
2018

35. Students’ self-worth protection and approaches to learning in higher education: predictors and consequences

Author

Cano, F, Martin, AJ, Ginns, P, Berbén, ABG, Cano, F, Martin, AJ, Ginns, P, and Berbén, ABG

Abstract

© 2017, Springer Science+Business Media B.V., part of Springer Nature. The aim of this study was to test a process model of students’ learning in higher education, linking anxiety, course experience (positive and negative), self-worth protection (SWP) (self-handicapping, defensive expectations, reflectivity), student approach to learning (SAL) (deep/surface), and achievement. Path and bootstrap analyses of data from 899 first-year university students showed that anxiety significantly predicted all SWP strategies and that positive course experience negatively predicted defensive expectations, whereas negative course experience was linked to higher levels of self-handicapping and reflectivity. Deep approach was linked negatively to self-handicapping and positively to reflectivity, whereas surface approach was associated positively with both self-handicapping and defensive expectations. Finally, deep approach positively predicted achievement and partially mediated the effect of self-handicapping on achievement. These findings support the validity of linking SWP with SAL and demonstrate meaningful connections between these and the anxiety and course experience of students. Implications for theory and practice are discussed.

Published
2018

36. Achievement in large-scale national numeracy assessment: An ecological study of motivation and student, home, and school predictors

Author

Martin, AJ, Lazendic, G, Martin, AJ, and Lazendic, G

Abstract

With the rise of large-scale academic assessment programs around the world, there is a need to better understand the factors predicting students' achievement in these assessment exercises. This investigation into national numeracy assessment drew on ecological and transactional conceptualizing involving student, student/home, and school factors. Student factors comprised mathematics ability, gender, and year group. Student/home factors comprised mathematics tutoring, mathematics competition participation, computer support for mathematics, and practice mathematics tests. School factors included schoolaverage mathematics ability, school-average practice mathematics tests and competition participation, and socioeducational status. These educational ecology factors were modeled as predictors of mathematics motivation. In turn, educational ecology factors and mathematics motivation were modeled as predictors of numeracy achievement. Data were drawn from N = 12,736 Australian elementary (Years 3 and 5) and secondary (Years 7 and 9) school students from 231 schools participating in a national numeracy assessment exercise. Multilevel structural equation modeling revealed that student and student/home factors (Level 1) and school factors (Level 2) explained significant variance in student- and school-level mathematics motivation. In turn, these factors explained significant variance in student- and school-level numeracy achievement. Findings hold implications for the nature, breadth, and depth of efforts aimed at improving mathematics motivation and numeracy achievement in large-scale assessment programs.

Published
2018

37. Load reduction instruction: Exploring a framework that assesses explicit instruction through to independent learning

Author

Martin, AJ, Evans, P, Martin, AJ, and Evans, P

Abstract

© 2018 Elsevier Ltd Load reduction instruction (LRI) is an instructional approach aimed at managing the cognitive burden on students in the initial stages of learning; then, as fluency and automaticity develop, students are encouraged to engage in guided independent learning. LRI comprises five factors: difficulty reduction, support and scaffolding, practice, feedback, and guided independence. This study examined an instrument (the Load Reduction Instruction Scale, LRIS) aimed at assessing these five factors. Among a sample of high school students from 40 classrooms, findings supported the validity of the LRIS, the conceptualising underpinning it, and its potential to guide instructional practice.

Published
2018

38. The roles of anxious and prosocial behavior in early academic performance: A population-based study examining unique and moderated effects

Author

Collie, RJ, Martin, AJ, Roberts, CL, Nassar, N, Collie, RJ, Martin, AJ, Roberts, CL, and Nassar, N

Abstract

© 2018 Elsevier Inc. We examined two social and emotional behaviors (anxious and prosocial behavior) and their links with academic achievement among kindergarten students. We conducted a population-level examination among kindergarten students in New South Wales in 2009 and 2012 (N = 206,210) of the extent to which the two behaviors are associated with kindergarten achievement (unique and moderated effects). With a subsample (n = 52,661), we examined additional links to grade 3 achievement. Findings showed that anxious behavior was not, whereas prosocial behavior was, meaningfully associated with kindergarten achievement. There was no evidence of moderation. With the subsample, prosocial behavior was meaningfully associated with kindergarten achievement, and kindergarten achievement was associated with grade 3 achievement. An indirect association from prosocial behavior to grade 3 achievement via kindergarten achievement was also evident. Together, the findings yield information that is relevant to efforts aiming to promote academic achievement in the early years of schooling.

Published
2018

40. The impact of general anesthesia on child development and school performance: a population-based study

Author

Schneuer, FJ, Bentley, JP, Davidson, AJ, Holland, AJA, Badawi, N, Martin, AJ, Skowno, J, Lain, SJ, Nassar, N, Schneuer, FJ, Bentley, JP, Davidson, AJ, Holland, AJA, Badawi, N, Martin, AJ, Skowno, J, Lain, SJ, and Nassar, N

Abstract

BACKGROUND: There has been considerable interest in the possible adverse neurocognitive effects of exposure to general anesthesia and surgery in early childhood. AIMS: The aim of this data linkage study was to investigate developmental and school performance outcomes of children undergoing procedures requiring general anesthesia in early childhood. METHODS: We included children born in New South Wales, Australia of 37+ weeks' gestation without major congenital anomalies or neurodevelopmental disability with either a school entry developmental assessment in 2009, 2012, or Grade-3 school test results in 2008-2014. We compared children exposed to general anesthesia aged <48 months to those without any hospitalization. Children with only 1 hospitalization with general anesthesia and no other hospitalization were assessed separately. Outcomes included being classified developmentally high risk at school entry and scoring below national minimum standard in school numeracy and reading tests. RESULTS: Of 211 978 children included, 82 156 had developmental assessment and 153 025 had school test results, with 12 848 (15.7%) and 25 032 (16.4%) exposed to general anesthesia, respectively. Children exposed to general anesthesia had 17%, 34%, and 23% increased odds of being developmentally high risk (adjusted odds ratio [aOR]: 1.17; 95% CI: 1.07-1.29); or scoring below the national minimum standard in numeracy (aOR: 1.34; 95% CI: 1.21-1.48) and reading (aOR: 1.23; 95% CI: 1.12-1.36), respectively. Although the risk for being developmentally high risk and poor reading attenuated for children with only 1 hospitalization and exposure to general anesthesia, the association with poor numeracy results remained. CONCLUSION: Children exposed to general anesthesia before 4 years have poorer development at school entry and school performance. While the association among children with 1 hospitalization with 1 general anesthesia and no other hospitalization was attenuated, poor numeracy outc

Published
2018

41. Simulation and Quality in Clinical Education

Author

Sunderland, AB, Nicklin, J, and martin, AJ

Abstract

Background Simulation-based education (SBE) has become commonplace in healthcare education within hospitals, higher education institutions, the private healthcare sector, and private education providers. The standards and quality of delivery vary across the UK (1), leading to differing degrees of learning for healthcare professionals. This variance in standards makes research into the impact of SBE on the end user (the patient) difficult to measure. Review The delivery of SBE needs to be of a high standard if learning via this pedagogy is to be maximised and benefits to patients accurately assessed. This article aims to summarise the importance of quality within clinical SBE and how it can be achieved and maintained to produce a measurable impact on patient care. The current progress of the implementation of UK national standards for SBE is included to highlight the need for standardisation and guidance to support simulation centres and individuals to benchmark practice and work towards accreditation through quality measurement and monitoring processes. Suggestions are made on how such standards will affect the future of SBE and all those involved. Conclusion There is a clear need for the development of national standards for SBE delivery and for a stepped approach [i.e. minimum, intermediate, and advanced standards] depending on the size, capacity, and frequency of SBE education delivery. Considerable financial outlay will be required to monitor standards effectively. The enhanced use of current and future technologies should be considered with regards to monitoring standards as well as data collection for future research opportunities. Keywords Simulation, quality improvement, educational standards

Published
2017

43. Search for quark contact interactions in dijet angular distributions in pp collisions at root s=7 TeV measured with the ATLAS detector

Author

Aad, G[ 1 ], Abbott, B[ 138 ], Abdallah, J[ 16 ], Abdelalim, AA[ 67 ], Abdesselam, A[ 145 ], Abdinov, O[ 15 ], Abi, B[ 139 ], Abolins, M[ 112 ], Abramowicz, H[ 193 ], Abreu, H[ 142 ], Acerbi, 113, E[, 114, ], Acharya, Bs[, 206, 207, ], Ackers, M[ 31 ], Adams, DL[ 36 ], Addy, TN[ 76 ], Adelman, J[ 221 ], Aderholz, M[ 124 ], Adomeit, S[ 123 ], Adorisio, C[, 54, 55, ], Adragna, R[ 99 ], Adye, T[ 160 ], Aefsky, S[ 33 ], Aguilar, Saavedra, Ja[, 153, 154, 155, ], Aharrouche, M[ 105 ], Ahlen, SP[ 32 ], Ahles, F[ 1 ], Ahmad, A[ 188 ], Ahmed, H[ 3 ], Ahsan, M[ 59 ], Aielli, 165, G[, 166, ], Akdogan, T[ 25 ], Akesson, TPA[ 103 ], Akimoto, 195, G[, 196, ], Akimov, AV[ 119 ], Aktas, A[ 1 ], Alam, MS[ 2 ], Alam, MA[ 100 ], Albrand, S[ 75 ], Aleksa, M[ 43 ], Aleksandrov, IN[ 87 ], Aleppo, 113, M[, Alessandria, F[ 113 ], Alexa, C[ 37 ], Alexander, G[ 193 ], Alexandre, G[ 67 ], Alexopoulos, T[ 14 ], Alhroob, M[ 31 ], Aliev, M[ 22 ], Alimonti, G[ 113 ], Alison, J[ 148 ], Aliyev, M[ 15 ], Allport, PP[ 96 ], Allwood Spiers, SE[ 73 ], Almond, J[ 106 ], Aloisio, 127, A[, 128, ], Alon, R[ 217 ], Alonso, A[ 103 ], Alonso, J[, 20, 21, ], Alviggi, Mg[, 127, Amako, K[ 88 ], Amaral, P[ 43 ], Ambrosio, G[ 113 ], Amelung, C[ 33 ], Ammosov, VV[ 159 ], Amorim, 153, A[, 234, ], Amoros, 211, G[, 212, 213, ], Amram, N[ 193 ], Anastopoulos, C[ 176 ], Andeen, T[ 52 ], Anders, CF[ 31 ], Anderson, KJ[ 44 ], Andreazza, 113, A[, Andrei, V[ 78 ], Andrieux, ML[ 75 ], Anduaga, XS[ 92 ], Angerami, A[ 52 ], Anghinolfi, F[ 43 ], Anjos, N[ 153 ], Annovi, A[ 66 ], Antonaki, A[ 13 ], Antonelli, M[ 66 ], Antonelli, S[, 29, 30, ], Antos, J[ 182 ], Antunovic, B[ 60 ], Anulli, F[ 163 ], Aoun, S[ 107 ], Apolle, R[ 145 ], Arabidze, G[ 112 ], Aracena, I[ 180 ], Arai, Y[ 88 ], Arce, ATH[ 63 ], Archambault, JP[ 42 ], Arfaoui, S[ 43 ], Arguin, Jf[, 20, Argyropoulos, T[ 14 ], Arik, E[ 25 ], Arik, M[ 25 ], Armbruster, AJ[ 111 ], Arms, KE[ 136 ], Armstrong, SR[ 36 ], Arnaez, O[ 9 ], Arnault, C[ 142 ], Artamonov, A[ 120 ], Arutinov, D[ 31 ], Asai, M[ 180 ], Asai, 195, S[, Asfandiyarov, R[ 218 ], Ask, S[ 41 ], Asman, 185, B[, 186, ], Asner, D[ 42 ], Asquith, L[ 10 ], Assamagan, K[ 36 ], Astbury, A[ 215 ], Astvatsatourov, A[ 72 ], Atoian, G[ 221 ], Aubert, B[ 9 ], Auerbach, B[ 221 ], Auge, E[ 142 ], Augsten, K[ 158 ], Aurousseau, M[ 9 ], Austin, N[ 96 ], Avolio, G[ 205 ], Avramidou, R[ 14 ], Axen, D[ 214 ], C[ 74 ], Ay, Azuelos, G[ 118 ], Azuma, 195, Y[, Baak, MA[ 43 ], Baccaglioni, G[ 113 ], Bacci, 167, C[, 168, ], Bach, Am[, 20, Bachacou, H[ 173 ], Bachas, K[ 43 ], Bachy, G[ 43 ], Backes, M[ 67 ], Badescu, E[ 37 ], Bagnaia, 163, P[, 164, ], Bai, Y[ 47 ], Bailey, DC[ 199 ], Bain, T[ 199 ], Baines, JT[ 160 ], Baker, OK[ 221 ], Baker, MD[ 36 ], Baker, S[ 101 ], Pedrosa, FBD[ 43 ], Banas, E[ 57 ], Banerjee, P[ 118 ], Banerjee, S[ 215 ], Banfi, 113, D[, Bangert, 163, A[, 174, ], Bansal, V[ 215 ], Baranov, SP[ 119 ], Baranov, S[ 87 ], Barashkou, A[ 87 ], Galtieri, Ab[, 20, Barber, T[ 41 ], Barberio, EL[ 110 ], Barberis, D[, 68, 69, ], Barbero, M[ 31 ], Bardin, DY[ 87 ], Barillari, T[ 124 ], Barisonzi, M[ 220 ], Barklow, T[ 180 ], Barlow, N[ 41 ], Barnett, BM[ 160 ], Barnett, Rm[, 20, Baroncelli, A[ 167 ], Barone, M[ 66 ], Barr, AJ[ 145 ], Barreiro, F[ 104 ], da Costa, JBG[ 77 ], Barrillon, P[ 142 ], Bartoldus, R[ 180 ], Bartsch, D[ 31 ], Bates, RL[ 73 ], Batkova, L[ 181 ], Batley, JR[ 41 ], Battaglia, A[ 23 ], Battistin, M[ 43 ], Battistoni, G[ 113 ], Bauer, F[ 173 ], Bawa, HS[ 180 ], Bazalova, M[ 156 ], Beare, B[ 199 ], Beau, T[ 102 ], Beauchemin, PH[ 145 ], Beccherle, R[ 68 ], Bechtle, R[ 60 ], Beck, GA[ 99 ], Beck, HP[ 23 ], Beckingham, M[ 1 ], Becks, KH[ 220 ], Beddall, AJ[ 27 ], Beddall, A[ 27 ], Bednyakov, VA[ 87 ], Bee, C[ 107 ], Begel, M[ 36 ], Harpaz, SB[ 192 ], Behera, PK[ 85 ], Beimforde, M[ 124 ], Belanger Champagne, C[ 210 ], Belhorma, B[ 75 ], Bell, PJ[ 67 ], Bell, WH[ 67 ], Bella, G[ 193 ], Bellagamba, L[ 29 ], Bellina, F[ 43 ], Bellomo, 113, G[, Bellomo, M[ 146 ], Belloni, A[ 77 ], Belotskiy, K[ 121 ], Beltramello, O[ 43 ], Ben Ami, S[ 192 ], Benary, O[ 193 ], Benchekroun, D[ 169 ], Benchouk, C[ 107 ], Bendel, M[ 105 ], Benedict, BH[ 205 ], Benekos, N[ 209 ], Benhammou, Y[ 193 ], Benincasa, GP[ 153 ], Benjamin, DP[ 63 ], Benoit, M[ 142 ], Bensinger, JR[ 33 ], Benslama, K[ 161 ], Bentvelsen, 131, S[, 132, ], Beretta, M[ 66 ], Berge, D[ 43 ], Kuutmann, EB[ 60 ], Berger, N[ 9 ], Berghaus, F[ 215 ], Berglund, E[ 67 ], Beringer, J[, 21, 20, ], Bernardet, K[ 107 ], Bernat, P[ 142 ], Bernhard, R[ 1 ], Bernius, C[ 101 ], Berry, T[ 100 ], Bertin, A[, 29, Bertinelli, F[ 43 ], Bertolucci, 150, F[, 151, ], Bertolucci, S[ 66 ], Besana, Mi[, 113, Besson, N[ 173 ], Bethke, S[ 124 ], Bhimji, W[ 64 ], Bianchi, RM[ 1 ], Bianco, M[, 94, 95, ], Biebel, O[ 123 ], Biesiada, Biglietti, 163, M[, Bilokon, H[ 66 ], Binder, M[ 123 ], Bindi, M[, 29, Binet, S[ 142 ], Bingul, A[ 27 ], Bini, 163, C[, Biscarat, C[ 226 ], Bischof, R[ 84 ], Bitenc, U[ 1 ], Black, KM[ 77 ], Blair, RE[ 10 ], 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178 ], Zitoun, R[ 9 ], Zivkovic, L[ 52 ], Zmouchko, VV[ 159 ], Zobernig, G[ 218 ], Zoccoli, Zolnierowski, Y[ 9 ], Zsenei, A[ 43 ], zur Nedden, M[ 22 ], Zutshi, V[ 133 ]Cauz, Diego, Cobal, Marina, Del Papa, Carlo, DE LOTTO, Barbara, Giordani, Mario, Aad, G, Abbott, B, Abdallah, J, Abdelalim, Aa, Abdesselam, A, Abdinov, O, Abi, B, Abolins, M, Abramowicz, H, Abreu, H, Acerbi, E, Acharya, B, Ackers, M, Adams, Dl, Addy, Tn, Adelman, J, Aderholz, M, Adomeit, S, Adorisio, C, Adragna, R, Adye, T, Aefsky, S, Aguilar Saavedra, Ja, Aharrouche, M, Ahlen, Sp, Ahles, F, Ahmad, A, Ahmed, H, Ahsan, M, Aielli, G, Akdogan, T, Akesson, Tpa, Akimoto, G, Akimov, Av, Aktas, A, Alam, M, Alam, Ma, Albrand, S, Aleksa, M, Aleksandrov, In, Aleppo, M, Alessandria, F, Alexa, C, Alexander, G, Alexandre, G, Alexopoulos, T, Alhroob, M, Aliev, M, Alimonti, G, Alison, J, Aliyev, M, Allport, Pp, Allwood Spiers, Se, Almond, J, Aloisio, A, Alon, R, Alonso, A, Alonso, J, Alviggi, Mg, Amako, K, Amaral, P, Ambrosio, G, 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Vaniachine, A, Vankov, P, Vannucci, F, Rodriguez, Fv, Vari, R, Varnes, Ew, Varouchas, D, Vartapetian, A, Varvell, Ke, Vasilyeva, L, Vassilakopoulos, Vi, Vazeille, F, Vegni, G, Veillet, Jj, Vellidis, C, Veloso, F, Veness, R, Veneziano, S, Ventura, A, Ventura, D, Ventura, S, Venturi, M, Venturi, N, Vercesi, V, Verducci, M, Verkerke, W, Vermeulen, Jc, Vertogardov, L, Vetterli, Mc, Vichou, I, Vickey, T, Viehhauser, Gha, Viel, S, Villa, M, Villani, Eg, Perez, Mv, Vilucchi, E, Vincter, Mg, Vinek, E, Vinogradov, Vb, Virchaux, M, Viret, S, Virzi, J, Vitale, A, Vitells, O, Vivarelli, I, Vaque, Fv, Vlachos, S, Vlasak, M, Vlasov, N, Vogel, A, Vokac, P, Volpi, M, Volpini, G, von der Schmitt, H, von Loeben, J, von Radziewski, H, von Toerne, E, Vorobel, V, Vorobiev, Ap, Vorwerk, V, Vos, M, Voss, R, Voss, Tt, Vossebeld, Jh, Vovenko, A, Vranjes, N, Milosavljevic, Mv, Vrba, V, Vreeswijk, M, Anh, Tv, Vudragovic, D, Vuillermet, R, Vukotic, I, Wagner, W, Wagner, P, Wahlen, H, Walbersloh, J, Walder, J, 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Vv, Zobernig, G, Zoccoli, A, Zolnierowski, Y, Zsenei, A, zur Nedden, M, and Zutshi, V.

Subjects
Astrophysics::High Energy Astrophysical Phenomena, High Energy Physics::Phenomenology, High Energy Physics::Experiment
Abstract

""Dijet angular distributions from the first LHC pp collisions at center-of-mass energy root s = 7 TeV have been measured with the ATLAS detector. The dataset used for this analysis represents an integrated luminosity of 3.1 pb(-1). Dijet chi distributions and centrality ratios have been measured up to dijet masses of 2.8 TeV, and found to be in good agreement with Standard Model predictions. Analysis of the chi distributions excludes quark contact interactions with a compositeness scale Lambda below 3.4 TeV, at 95% confidence level, significantly exceeding previous limits. (C) 2010 CERN. Published by Elsevier B.V. All rights reserved.""

Published
2011

45. ADHD, personal and interpersonal agency, and achievement: Exploring links from a social cognitive theory perspective

Author

Martin, AJ, Burns, EC, Collie, RJ, Martin, AJ, Burns, EC, and Collie, RJ

Abstract

© 2016 Elsevier Inc. Harnessing social cognitive theory (SCT), we investigated the roles of personal agency (self-efficacy and perceived control) and interpersonal agency (relational support) in the academic achievement (via literacy and numeracy testing) of students with attention-deficit/hyperactivity disorder (ADHD) and their non-ADHD peers. A sample of N = 164 students diagnosed with ADHD were investigated alongside N = 4658 non-ADHD peers in the same schools and year levels. Using structural equation modeling, findings showed that self-efficacy and relational support were consistently associated with better academic achievement for both groups, but with positive effects significantly stronger for students with ADHD than for students without ADHD. Although perceived control was significantly associated with achievement for students without ADHD and not significantly so for students with ADHD, there was not much difference in absolute size of perceived control effects for the two groups. Findings are relevant to theory, research, and practice identifying motivational factors and processes that may assist in closing well-known achievement gaps for students with ADHD whilst also maintaining positive outcomes for students without ADHD.

Published
2017

46. Academic risk and resilience for children and young people in Asia

Author

Li, H, Martin, AJ, Yeung, WJJ, Li, H, Martin, AJ, and Yeung, WJJ

Abstract

© 2017 Informa UK Limited, trading as Taylor & Francis Group. In studies of academic resilience, researchers seek to identify factors that protect against adverse effects caused by risk and stress, and which ultimately assist students to be academically successful. However, because relatively few studies are conducted in Asian settings, Western-based research may have limited application for policy and prevention in the Asian context. It is therefore important to expand the context and culture in which resilience research takes place. This paper highlights academic resilience factors among Asian students that are located in the multiple levels of the social ecology (including individual, peers, family and school). This is consistent with results from the Western context. However, it also reports on some differences in academic resilience factors that are found both within Asian countries and between Asian and Western countries. From these results, we might thus conclude that alongside pan-human factors, Asian students’ academic success can also be considered in part due to uniquely Asian attributes. This reaffirms the importance of considering culture and national context in studies of academic resilience. Taken as a whole, this collection of papers showcases multiple approaches to building academic resilience and empowering students and their educators and caregivers across the Asian region.

Published
2017

47. Adaptability-What it is and what it is not: Comment on Chandra and Leong (2016)

Author

Martin, AJ and Martin, AJ

Abstract

Chandra and Leong (2016) propose a new model of adaptability: the diversified portfolio model (DPM) of adaptability. Further thought and research on adaptability is a welcome addition to the limited body of work conducted on this topic to date. However, in their discussion there is a lack of definitional clarity, and there is frequent conflation of adaptability and resilience. It is also the case that the hypothesized adaptability model is general and could apply to many psychological constructs and processes (not just adaptability). In addition, there are gaps in research suggested by the authors that have been addressed by other researchers and there is a good deal of contemporary adaptability research that is not cited. Addressing these limitations in future work is vital to the further development of theory, research, and practice in the area of adaptability.

Published
2017

48. The effect of anti-angiogenic agents on overall survival in metastatic oesophago-gastric cancer: A systematic review and meta-analysis

Author

Chan, DL, Sjoquist, KM, Goldstein, D, Price, TJ, Martin, AJ, Bang, YJ, Kang, YK, Pavlakis, N, Chan, DL, Sjoquist, KM, Goldstein, D, Price, TJ, Martin, AJ, Bang, YJ, Kang, YK, and Pavlakis, N

Abstract

Background Studies of anti-angiogenic agents (AAs), combined with chemotherapy (chemo) or as monotherapy in metastatic oesophago-gastric cancer (mOGC), have reported mixed outcomes. We undertook systematic review and meta-analysis to determine their overall benefits and harms. Methods Randomized controlled trials in mOGC were sought investigating the addition of AAs to standard therapy (best supportive care or chemo). The primary endpoint was overall survival (OS) with secondary endpoints progression-free survival (PFS), overall response rate (ORR) and toxicity. Estimates of treatment effect from individual trials were combined using standard techniques. Subgroup analyses were performed by line of therapy, region, age, performance status, histological type, number of metastatic sites, primary site, mechanism of action and HER2 status. Results Fifteen trials evaluating 3502 patients were included in quantitative analysis. The addition of AAs was associated with improved OS: HR 0ô81 (95% CI 0ô75-0ô88, p<0ô00001) and improved PFS: HR 0ô68 (95% CI 0ô63-0ô74, p<0ô00001). Subgroup analyses favoured greater benefit for OS in 2nd /3rd line settings (HR 0ô74) compared to 1st -line settings (HR 0ô91) (X2 = 6ô00, p = 0ô01). OS benefit was seen across all regions-Asia (HR 0ô83) and rest of world (HR 0ô75)-without significant subgroup interaction. Results from 8 trials evaluating 2602 patients were pooled for toxicity > = Grade 3: with OR 1ô39 (95% CI 1ô17-1ô65). Conclusions The addition of AAs to standard therapy in mOGC improves OS. Improved efficacy was only observed in 2nd - or 3rd -line setting and not in 1st -line setting. Consistent OS benefit was present across all geographical regions. This benefit is at the expense of increased overall toxicity.

Published
2017

49. Getting into flow in the arts classroom: Research findings and implications for practice

Author

Mansour, M, Martin, AJ, Anderson, M, Gibson, R, Mansour, M, Martin, AJ, Anderson, M, and Gibson, R

Abstract

Research has shown that participation in the arts at school and in the classroom has many academic and personal well-being benefits. Here we outline some of the key effects of arts participation, with particular focus on one of its psychological yields: “flow”. We then define flow and describe its nine ingredients with particular attention to how these occur in the arts classroom: action-awareness merging, clear goals, unambiguous feedback, concentration on the task at hand, sense of control, loss of selfconsciousness, transformation of time, and autotelic experience. Suggested implications for arts educators are then identified to provide guidance on how to build flow into the everyday activities of the arts classroom. Moreover, although we focus on the arts and the arts classroom, applications and implications for other subjects and classrooms are readily evident.ii.

Published
2017

50. Search for supersymmetry in pp collisions at root s=7 Te V in final states with missing transverse momentum and b-jets with the ATLAS detector

Author

Aad, G, Abbott, B, Abdallah, J, Khalek, Sa, Abdelalim, Aa, Abdesselam, A, Abdinov, O, Abi, B, Abolins, M, Abouzeid, Os, Abramowicz, H, Abreu, H, Acerbi, E, Acharya, Bs, Adamczyk, L, Adams, Dl, Addy, Tn, Adelman, J, Aderholz, M, Adomeit, S, Adragna, P, Adye, T, Aefsky, S, Aguilar Saavedra JA, Aharrouche, M, Ahlen, Sp, Ahles, F, Ahmad, A, Ahsan, M, Aielli, G, Akdogan, T, Akesson, Tpa, Akimoto, G, Akimov, Av, Akiyama, A, Alam, Ms, Alam, Ma, Albert, J, Albrand, S, Aleksa, M, Aleksandrov, In, Alessandria, F, Alexa, C, Alexander, G, Alexandre, G, Alexopoulos, T, Alhroob, M, Aliev, M, Alimonti, G, Alison, J, Aliyev, M, Allbrooke, Bmm, Allport, Pp, Allwood Spiers SE, Almond, J, Aloisio, A, Alon, R, Alonso, A, Gonzalez, Ba, Alviggi, Mg, Amako, K, Amaral, P, Amelung, C, Ammosov, Vv, Amorim, A, Amoros, G, Amram, N, Anastopoulos, C, Ancu, Ls, Andari, N, Andeen, T, Anders, Cf, Anders, G, Anderson, Kj, Andreazza, A, Andrei, V, Andrieux, Ml, Anduaga, Xs, Angerami, A, Anghinolfi, F, Anisenkov, A, Anjos, N, Annovi, A, Antonaki, A, Antonelli, M, Antonov, A, Antos, J, Anulli, F, Aoun, S, Bella, La, Apolle, R, Arabidze, G, Aracena, I, Arai, Y, Arce, Ath, Arfaoui, S, Arguin, Jf, Arik, E, Arik, M, Armbruster, Aj, Arnaez, O, Arnal, V, Arnault, C, Artamonov, A, Artoni, G, Arutinov, D, Asai, S, Asfandiyarov, R, Ask, S, Asman, B, Asquith, L, Assamagan, K, Astbury, A, Astvatsatourov, A, Aubert, B, Auge, E, Augsten, K, Aurousseau, M, Avolio, G, Avramidou, R, Axen, D, Ay, C, Azuelos, G, Azuma, Y, Baak, Ma, Baccaglioni, G, Bacci, C, Bach, Am, Bachacou, H, Bachas, K, Backes, M, Backhaus, M, Badescu, E, Bagnaia, P, Bahinipati, S, Bai, Y, Bailey, Dc, Bain, T, Baines, Jt, Baker, Ok, Baker, Md, Baker, S, Banas, E, Banerjee, P, Banerjee, S, Banfi, D, Bangert, A, Bansal, V, Bansil, Hs, Barak, L, Baranov, Sp, Barashkou, A, Galtieri, Ab, Barber, T, Barberio, El, Barberis, D, Barbero, M, Bardin, Dy, Barillari, T, Barisonzi, M, Barklow, T, Barlow, N, Barnett, Bm, Barnett, Rm, Baroncelli, A, Barone, G, 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Subjects
High Energy Physics::Theory, Hardware_MEMORYSTRUCTURES, Settore FIS/01 - Fisica Sperimentale, High Energy Physics::Phenomenology, Subatomic Physics, High Energy Physics::Experiment
Abstract

The results of a search for supersymmetry in events with large missing transverse momentum and heavy-flavor jets using an integrated luminosity corresponding to 2.05 fb(-1) of pp collisions at root s = 7 TeV recorded with the ATLAS detector at the Large Hadron Collider are reported. No significant excess is observed with respect to the prediction for standard model processes. Results are interpreted in a variety of R-parity conserving models in which scalar bottoms and tops are the only scalar quarks to appear in the gluino decay cascade, and in an SO(10) model framework. Gluino masses up to 600-900 GeV are excluded, depending on the model considered.

Published
2012

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