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15 results on '"Martin‐García, David"'

2. CCND2 and CCND3 hijack immunoglobulin light-chain enhancers in cyclin D1− mantle cell lymphoma

Author

Martín-Garcia, David, Navarro, Alba, Valdés-Mas, Rafael, Clot, Guillem, Gutiérrez-Abril, Jesús, Prieto, Miriam, Ribera-Cortada, Inmaculada, Woroniecka, Renata, Rymkiewicz, Grzegorz, Bens, Susanne, de Leval, Laurence, Rosenwald, Andreas, Ferry, Judith A., Hsi, Eric D., Fu, Kai, Delabie, Jan, Weisenburger, Dennis, de Jong, Daphne, Climent, Fina, O'Connor, Sheila J., Swerdlow, Steven H., Torrents, David, Beltran, Sergi, Espinet, Blanca, González-Farré, Blanca, Veloza, Luis, Costa, Dolors, Matutes, Estella, Siebert, Reiner, Ott, German, Quintanilla-Martinez, Leticia, Jaffe, Elaine S., López-Otín, Carlos, Salaverria, Itziar, Puente, Xose S., Campo, Elias, and Beà, Sílvia

Published
2019
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3. A gene signature that distinguishes conventional and leukemic nonnodal mantle cell lymphoma helps predict outcome

Author

Clot, Guillem, Jares, Pedro, Giné, Eva, Navarro, Alba, Royo, Cristina, Pinyol, Magda, Martín-Garcia, David, Demajo, Santiago, Espinet, Blanca, Salar, Antonio, Ferrer, Ana, Muntañola, Ana, Aymerich, Marta, Rauert-Wunderlich, Hilka, Jaffe, Elaine S., Connors, Joseph M., Gascoyne, Randy D., Delabie, Jan, López-Guillermo, Armando, Ott, German, Wright, George W., Staudt, Louis M., Rosenwald, Andreas, Scott, David W., Rimsza, Lisa M., Beà, Sílvia, and Campo, Elías

Published
2018
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4. A comprehensive flow-cytometry-based immunophenotypic characterization of Burkitt-like lymphoma with 11q aberration

Author

Rymkiewicz, Grzegorz, Grygalewicz, Beata, Chechlinska, Magdalena, Blachnio, Katarzyna, Bystydzienski, Zbigniew, Romejko-Jarosinska, Joanna, Woroniecka, Renata, Zajdel, Michalina, Domanska-Czyz, Katarzyna, Martin-Garcia, David, Nadeu, Ferran, Swoboda, Pawel, Rygier, Jolanta, Pienkowska-Grela, Barbara, Siwicki, Jan Konrad, Prochorec-Sobieszek, Monika, Salaverria, Itziar, Siebert, Reiner, and Walewski, Jan

Published
2018
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5. Correction to: An Original Social Marketing Campaign to 'Try Vegan': Effectiveness and Impact on Quality of Life

Author

Díaz, Estela M., Lado, Nora, Martín-García, David F., Sirgy, Joe, Editorial Board Member, Alves, Helena, Series Editor, Tonon, Graciela, Editorial Board Member, Kraeger, Patsy, Editorial Board Member, Sarracino, Francesco, Editorial Board Member, Ludwigs, Kai, Editorial Board Member, Galan-Ladero, M. Mercedes, editor, and Rivera, Reynaldo G., editor

Published
2021
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6. Clinical impact of clonal and subclonal TP53, SF3B1, BIRC3, NOTCH1, and ATM mutations in chronic lymphocytic leukemia

Author

Nadeu, Ferran, Delgado, Julio, Royo, Cristina, Baumann, Tycho, Stankovic, Tatjana, Pinyol, Magda, Jares, Pedro, Navarro, Alba, Martín-García, David, Beà, Sílvia, Salaverria, Itziar, Oldreive, Ceri, Aymerich, Marta, Suárez-Cisneros, Helena, Rozman, Maria, Villamor, Neus, Colomer, Dolors, López-Guillermo, Armando, González, Marcos, Alcoceba, Miguel, Terol, Maria José, Colado, Enrique, Puente, Xose S., López-Otín, Carlos, Enjuanes, Anna, and Campo, Elías

Published
2016
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7. Landscape of somatic mutations and clonal evolution in mantle cell lymphoma

Author

Beà, Sílvia, Valdés-Mas, Rafael, Navarro, Alba, Salaverria, Itziar, Martín-Garcia, David, Jares, Pedro, Giné, Eva, Pinyol, Magda, Royo, Cristina, Nadeu, Ferran, Conde, Laura, Juan, Manel, Clot, Guillem, Vizán, Pedro, Di Croce, Luciano, Puente, Diana A., López-Guerra, Mónica, Moros, Alexandra, Roue, Gael, Aymerich, Marta, Villamor, Neus, Colomo, Lluís, Martínez, Antonio, Valera, Alexandra, Martín-Subero, José I., Amador, Virginia, Hernández, Luis, Rozman, Maria, Enjuanes, Anna, Forcada, Pilar, Muntañola, Ana, Hartmann, Elena M., Calasanz, María J., Rosenwald, Andreas, Ott, German, Hernández-Rivas, Jesús M., Klapper, Wolfram, Siebert, Reiner, Wiestner, Adrian, Wilson, Wyndham H., Colomer, Dolors, López-Guillermo, Armando, López-Otín, Carlos, Puente, Xose S., and Campo, Elías

Published
2013

9. Revised International Prognostic Index and genetic alterations are associated with early failure to R‐CHOP in patients with diffuse large B‐cell lymphoma

Author

Dlouhy, Ivan, primary, Karube, Kennosuke, additional, Enjuanes, Anna, additional, Salaverria, Itziar, additional, Nadeu, Ferran, additional, Ramis‐Zaldivar, Juan Enric, additional, Valero, Juan G., additional, Rivas‐Delgado, Alfredo, additional, Magnano, Laura, additional, Martin‐García, David, additional, Pérez‐Galán, Patricia, additional, Clot, Guillem, additional, Rovira, Jordina, additional, Jares, Pedro, additional, Balagué, Olga, additional, Giné, Eva, additional, Mozas, Pablo, additional, Briones, Javier, additional, Sancho, Juan‐Manuel, additional, Salar, Antonio, additional, Mercadal, Santiago, additional, Alcoceba, Miguel, additional, Valera, Alexandra, additional, Campo, Elías, additional, and López‐Guillermo, Armando, additional

Published
2021
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10. Revised International Prognostic Index and genetic alterations are associated with early failure to R‐CHOP in patients with diffuse large B‐cell lymphoma.

Author

Dlouhy, Ivan, Karube, Kennosuke, Enjuanes, Anna, Salaverria, Itziar, Nadeu, Ferran, Ramis‐Zaldivar, Juan Enric, Valero, Juan G., Rivas‐Delgado, Alfredo, Magnano, Laura, Martin‐García, David, Pérez‐Galán, Patricia, Clot, Guillem, Rovira, Jordina, Jares, Pedro, Balagué, Olga, Giné, Eva, Mozas, Pablo, Briones, Javier, Sancho, Juan‐Manuel, and Salar, Antonio

Subjects
ANTINEOPLASTIC combined chemotherapy protocols, CELL cycle regulation, EXTRACELLULAR matrix, GENE expression profiling, DIFFUSE large B-cell lymphomas, TUMOR microenvironment
Abstract

Summary: Relapsed or refractory diffuse large B‐cell lymphoma (DLBCL) cases have a poor outcome. Here we analysed clinico‐biological features in 373 DLBCL patients homogeneously treated with rituximab, cyclophosphamide, doxorubicin, vincristine and prednisolone (R‐CHOP), in order to identify variables associated with early failure to treatment (EF), defined as primary refractoriness or relapse within 12 months from diagnosis. In addition to clinical features, mutational status of 106 genes was studied by targeted next‐generation sequencing in 111 cases, copy number alterations in 87, and gene expression profile (GEP) in 39. Ninety‐seven cases (26%) were identified as EF and showed significantly shorter overall survival (OS). Patients with B symptoms, advanced stage, high levels of serum lactate dehydrogenase (LDH) or β2‐microglobulin, low lymphocyte/monocyte ratio and higher Revised International Prognostic Index (R‐IPI) scores, as well as those with BCL2 rearrangements more frequently showed EF, with R‐IPI being the most important in logistic regression. Mutations in NOTCH2, gains in 5p15·33 (TERT), 12q13 (CDK2), 12q14·1 (CDK4) and 12q15 (MDM2) showed predictive importance for EF independently from R‐IPI. GEP studies showed that EF cases were significantly enriched in sets related to cell cycle regulation and inflammatory response, while cases in response showed over‐representation of gene sets related to extra‐cellular matrix and tumour microenvironment. [ABSTRACT FROM AUTHOR]

Published
2022
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11. Expression of the transcribed ultraconserved region 70 and the related long non-coding RNA AC092652.2-202 has prognostic value in Chronic Lymphocytic Leukaemia

Author

Bomben, Riccardo, primary, Roisman, Alejandro, additional, D'Agaro, Tiziana, additional, Castellano, Giancarlo, additional, Baumann, Tycho, additional, Delgado, Julio, additional, López-Guillermo, Armando, additional, Zucchetto, Antonella, additional, Dal-Bo, Michele, additional, Bravin, Vanessa, additional, Slavutsky, Irma, additional, Vlasova, Anna, additional, Guigó, Roderic, additional, Martin-Subero, Jose I., additional, Chapaprieta, Vicente, additional, Beekman, Renee, additional, Martin-García, David, additional, Beà, Sílvia, additional, Salaverria, Itziar, additional, Aymerich, Marta, additional, Campo, Elias, additional, Gattei, Valter, additional, and Hernández, Luis, additional

Published
2018
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12. Expression of the transcribed ultraconserved region 70 and the related long non‐coding RNA AC092652.2‐202 has prognostic value in Chronic Lymphocytic Leukaemia.

Author

Bomben, Riccardo, Roisman, Alejandro, D'Agaro, Tiziana, Castellano, Giancarlo, Baumann, Tycho, Delgado, Julio, López‐Guillermo, Armando, Zucchetto, Antonella, Dal‐Bo, Michele, Bravin, Vanessa, Slavutsky, Irma, Vlasova, Anna, Guigó, Roderic, Martin‐Subero, Jose I., Chapaprieta, Vicente, Beekman, Renee, Martin‐García, David, Beà, Sílvia, Salaverria, Itziar, and Aymerich, Marta

Subjects
NON-coding RNA
Abstract

The article presents a study which explored the possible role of Transcribed Ultraconserved Region (T-UCR) in the pathogenesis of CLL. Topics include potential clinical value of the significantly modulated T-UCRs in two independent cohorts of chronic lymphocytic leukemia (CLL) patients, expression levels of uc.70 and uc.414 in the same cases studied by microarrays and in an independent series of CLL cases, and expression of uc.70-related transcripts using RNAseq data of CLL cases.

Published
2019
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13. Clinical Impact of Clonal and Subclonal TP53, SF3B1, BIRC3, and ATM Mutations in Chronic Lymphocytic Leukemia

Author

Nadeu, Ferran, Delgado, Julio, Royo, Cristina, Bauman, Tycho, Stankovic, Tatjana, Pinyol, Magda, Jares, Pedro, Navarro, Alba, Martín-García, David, Beà, Sílvia, Salaverria, Itziar, Oldreive, Ceri, Aymerich, Marta, Suárez-Cisneros, Helena, Rozman, Maria, Villamor, Neus, Colomer, Dolors, López-Guillermo, Armando, González, Marcos, Alcoceba, Miguel, Terol, María José, Colado, Enrique, Puente, Xose S, López-Otín, Carlos, Enjuanes, Anna, and Campo, Elías

Published
2015
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14. Gene Expression Profiling Signatures Allow the Identification of Unclassifiable Leukemic B-Cell Lymphoid Neoplasms

Author

Navarro, Alba, Clot, Guillem, Martinez-Trillos, Alejandra, Salaverria, Itziar, Martin-Garcia, David, Trim, Nicola, Fernandez, Veronica, Villamor, Neus, Colomer, Dolors, Pinyol, Magda, Jares, Pedro, Erber, Wendy N., Wiestner, Adrian, Wilson, Wyndham H., Siebert, Reiner, Aymerich, Marta, Lopez-Guillermo, Armando, Sánchez, Àlex, Campo, Elias, Matutes, Estella, and Beà, Sílvia

Published
2015
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15. Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia

Author

Law, Philip J., Berndt, Sonja I., Speedy, Helen E., Camp, Nicola J., Sava, Georgina P., Skibola, Christine F., Holroyd, Amy, Joseph, Vijai, Sunter, Nicola J., Nieters, Alexandra, Bea, Silvia, Monnereau, Alain, Martin-Garcia, David, Goldin, Lynn R., Clot, Guillem, Teras, Lauren R., Quintela, Inés, Birmann, Brenda M., Jayne, Sandrine, Cozen, Wendy, Majid, Aneela, Smedby, Karin E., Lan, Qing, Dearden, Claire, Brooks-Wilson, Angela R., Hall, Andrew G., Purdue, Mark P., Mainou-Fowler, Tryfonia, Vajdic, Claire M., Jackson, Graham H., Cocco, Pierluigi, Marr, Helen, Zhang, Yawei, Zheng, Tongzhang, Giles, Graham G., Lawrence, Charles, Call, Timothy G., Liebow, Mark, Melbye, Mads, Glimelius, Bengt, Mansouri, Larry, Glenn, Martha, Curtin, Karen, Diver, W Ryan, Link, Brian K., Conde, Lucia, Bracci, Paige M., Holly, Elizabeth A., Jackson, Rebecca D., Tinker, Lesley F., Benavente, Yolanda, Boffetta, Paolo, Brennan, Paul, Maynadie, Marc, McKay, James, Albanes, Demetrius, Weinstein, Stephanie, Wang, Zhaoming, Caporaso, Neil E., Morton, Lindsay M., Severson, Richard K., Riboli, Elio, Vineis, Paolo, Vermeulen, Roel C. H., Southey, Melissa C., Milne, Roger L., Clavel, Jacqueline, Topka, Sabine, Spinelli, John J., Kraft, Peter, Ennas, Maria Grazia, Summerfield, Geoffrey, Ferri, Giovanni M., Harris, Robert J., Miligi, Lucia, Pettitt, Andrew R., North, Kari E., Allsup, David J., Fraumeni, Joseph F., Bailey, James R., Offit, Kenneth, Pratt, Guy, Hjalgrim, Henrik, Pepper, Chris, Chanock, Stephen J., Fegan, Chris, Rosenquist, Richard, de Sanjose, Silvia, Carracedo, Angel, Dyer, Martin J. S., Catovsky, Daniel, Campo, Elias, Cerhan, James R., Allan, James M., Rothman, Nathanial, Houlston, Richard, and Slager, Susan

Abstract

Several chronic lymphocytic leukaemia (CLL) susceptibility loci have been reported; however, much of the heritable risk remains unidentified. Here we perform a meta-analysis of six genome-wide association studies, imputed using a merged reference panel of 1,000 Genomes and UK10K data, totalling 6,200 cases and 17,598 controls after replication. We identify nine risk loci at 1p36.11 (rs34676223, P=5.04 × 10−13), 1q42.13 (rs41271473, P=1.06 × 10−10), 4q24 (rs71597109, P=1.37 × 10−10), 4q35.1 (rs57214277, P=3.69 × 10−8), 6p21.31 (rs3800461, P=1.97 × 10−8), 11q23.2 (rs61904987, P=2.64 × 10−11), 18q21.1 (rs1036935, P=3.27 × 10−8), 19p13.3 (rs7254272, P=4.67 × 10−8) and 22q13.33 (rs140522, P=2.70 × 10−9). These new and established risk loci map to areas of active chromatin and show an over-representation of transcription factor binding for the key determinants of B-cell development and immune response.

Published
2017
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