156 results on '"Martin, Ruth L"'
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2. In-vitro modeling of intravenous drug precipitation by the optical spatial precipitation analyzer (OSPREY)
3. Drug-induced QT prolongation: Concordance of preclinical anesthetized canine model in relation to published clinical observations for ten CiPA drugs
4. Discovery of A-910, a Highly Potent and Orally Bioavailable Dual MerTK/Axl-Selective Tyrosine Kinase Inhibitor
5. In-vitro Modeling of Intravenous Drug Precipitation by the Optical Spatial Precipitation Analyzer (OSPREY)
6. Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours
7. Characterization of A-935142, a hERG enhancer, in the presence and absence of standard hERG blockers
8. Ventricular rate adaptation: A novel, rapid, cellular-based in-vitro assay to identify proarrhythmic and torsadogenic compounds
9. A novel secretagogue increases cardiac contractility by enhancement of L-type Ca2+ current
10. Author Correction: Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours
11. Electrophysiologic characterization of a novel hERG channel activator
12. Integrated Risk Assessment of Cardiovascular Safety in Drug Discovery
13. Comparative analysis of inactivated-state block of N-type (Cav2.2) calcium channels
14. The effects of plasma proteins on delayed repolarization in vitro with cisapride, risperidone, and d, l-sotalol
15. Functional consequences of methionine oxidation of hERG potassium channels
16. Block of hERG channel by ziprasidone: Biophysical properties and molecular determinants
17. Preclinical Characterization of A-582941: A Novel α7 Neuronal Nicotinic Receptor Agonist with Broad Spectrum Cognition-Enhancing Properties
18. ALTERING EXTRACELLULAR POTASSIUM CONCENTRATION DOES NOT MODULATE DRUG BLOCK OF HUMAN ETHER-A-GO-GO-RELATED GENE (hERG) CHANNELS
19. Utility of hERG Assays as Surrogate Markers of Delayed Cardiac Repolarization and QT Safety
20. Alterations in ATP-sensitive potassium channel sensitivity to ATP in failing human hearts
21. Cardiac sodium channels expressed in a peripheral neurotumor-derived cell line, RT4-B8
22. The [ 3H]dofetilide binding assay is a predictive screening tool for hERG blockade and proarrhythmia: Comparison of intact cell and membrane preparations and effects of altering [K +] o
23. A 3,4-diaminopyridine-insensitive, Ca(super 2+)-independent transient outward K(super +) current in cardiac ventricular myocytes
24. Abstract LB-A23: Discovery of a potent catalytic p300/CBP inhibitor that targets lineage-specific tumors
25. Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours
26. In vitro studies on a class of quinoline containing histamine H3 antagonists
27. Temperature Effects on Pharmacologic Enhancement of L-Type Calcium Current
28. Abstract C202: Discovery and initial characterization of the clinical compound ABT-348, a potent inhibitor of the VEGF, PDGF, and Aurora kinase families.
29. Drug-Induced hERG Current Enhancement is Modulated by Extracellular Proton and Potassium
30. In Vitro Cardiac Safety Profiling of a Novel Benzyl-Ethylamine Compound
31. Optimization of a Cav1.2 Cell Line for Use on QPatch and PatchXpress
32. Cannabinoid (CB) Receptors are not Involved in A-955840 Induced Negative Inotropic Effects in Isolated Cardiac Myocytes
33. Do hERG Enhancers and Blockers Compete?
34. Ion Channel Toolbox for Cardiac Safety Evaluation
35. Electrophysiologic Characterization of a Complex hERG Channel Activator
36. An evaluation of 3,4-methylenedioxy phenyl replacements in the aminopiperidine chromone class of MCHr1 antagonists
37. Preclinical Characterization of A-582941: A Novel α7 Neuronal Nicotinic Receptor Agonist with Broad Spectrum Cognition-Enhancing Properties
38. AN IN VITRO EXAMINATION OF DELAYED REPOLARIZATION: HOW PLASMA PROTEIN BINDING INFLUENCES DRUG EFFECTS
39. Syntheses of Potent, Selective, and Orally Bioavailable Indazole-Pyridine Series of Protein Kinase B/Akt Inhibitors with Reduced Hypotension
40. Hydroxypropyl β-Cyclodextrins: A Misleading Vehicle for the In Vitro hERG Current Assay
41. 1,4-Dihydroindeno[1,2-c]pyrazoles with Acetylenic Side Chains as Novel and Potent Multitargeted Receptor Tyrosine Kinase Inhibitors with Low Affinity for the hERG Ion Channel
42. Discovery of N-(4-(3-Amino-1H-indazol-4-yl)phenyl)-N‘-(2-fluoro-5-methylphenyl)urea (ABT-869), a 3-Aminoindazole-Based Orally Active Multitargeted Receptor Tyrosine Kinase Inhibitor
43. In Vitro Preclinical Cardiac Assessment of Tolterodine and Terodiline: Multiple Factors Predict the Clinical Experience
44. ABT-089: Pharmacological Properties of a Neuronal Nicotinic Acetylcholine Receptor Agonist for the Potential Treatment of Cognitive Disorders
45. The Utility of hERG and Repolarization Assays in Evaluating Delayed Cardiac Repolarization: Influence of Multi-Channel Block
46. Newly Cloned Threshold Channels
47. Slowly Inactivating Sodium Currents are Reduced by Exposure to Oxidative Stress
48. ABT-089: Pharmacological Properties of a Neuronal Nicotinic Acetylcholine Receptor Agonist for the Potential Treatment of Cognitive Disorders.
49. A 3,4-diaminopyridine-insensitive, Ca2+-independent transient outward K+ current in cardiac...
50. A 3,4-diaminopyridine-insensitive, Ca2+-independent transient outward K+ current in cardiac ventricular myocytes.
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