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2. Global position paper on cardiovascular regenerative medicine

Author

Fernández-Avilés, Francisco, Sanz-Ruiz, Ricardo, Climent, Andreu M, Badimon, Lina, Bolli, Roberto, Charron, Dominique, Fuster, Valentin, Janssens, Stefan, Kastrup, Jens, Kim, Hyo-Soo, Lüscher, Thomas F, Martin, John F, Menasché, Philippe, Simari, Robert D, Stone, Gregg W, Terzic, Andre, Willerson, James T, Wu, Joseph C, Group, the TACTICS Writing, Broughton, Kathleen, DiFede, Darcy L, Dimmeler, Stefanie, Madonna, Rosalinda, Penn, Marc S, Sussman, Mark A, Sluijter, Joost PG, Wollert, Kai C, Balkan, Wayne, Chamuleau, Steven, Fernández-Santos, María Eugenia, Goliasch, Georg, Gyöngyösi, Mariann, Hare, Joshua M, Tompkins, Bryon A, Winkler, Johannes, Bayés-Genís, Antoni, Henry, Timothy D, Taylor, Doris A, Lerman, Amir, Pelacho, Beatriz, Prosper, Felipe, Perin, Emerson C, Pompilio, Giulio, Gersh, Bernard, Bartunek, Jozef, Duckers, Eric, Ferdinandy, Péter, Losordo, Douglas W, Sánchez, Pedro L, Sherman, Warren, Wojakowski, Wojtek, Zeiher, Andreas, Roncalli, Jerome, Mathur, Anthony, Crea, Filippo, D´Amario, Domenico, Povsic, Thomas J, Traverse, Jay, and Ylä-Herttuala, Seppo

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Clinical Sciences, Cardiovascular Diseases, Consensus, Humans, Precision Medicine, Regenerative Medicine, TACTICS (Transnational Alliance for Regenerative Therapies in Cardiovascular Syndromes) Writing Group, Authors/Task Force Members. Chairpersons, Basic Research Subcommittee, Translational Research Subcommittee, Challenges of Cardiovascular Regenerative Medicine Subcommittee, Tissue Engineering Subcommittee, Delivery, Navigation, Tracking and Assessment Subcommittee, Clinical Trials Subcommittee, Regulatory and funding strategies subcommittee, Delivery, Navigation, Tracking and Assessment Subcommittee, Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology, Cardiovascular medicine and haematology, Clinical sciences
Published
2017

3. Optical Transition Radiation Monitor for the T2K Experiment

Author

Bhadra, Sampa, Cadabeschi, Mircea, de Perio, Patrick, Galymov, Vyacheslav, Hartz, Mark, Kirby, Brian, Konaka, Akira, Marino, Alysia D., Martin, John F., Morris, David, and Stawnyczy, Leif

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract

An Optical Transition Radiation monitor has been developed for the proton beam-line of the T2K long base-line neutrino oscillation experiment. The monitor operates in the highly radioactive environment in proximity to the T2K target. It uses optical transition radiation, the light emitted from a thin metallic foil when the charged beam passes through it, to form a 2D image of a 30 GeV proton beam. One of its key features is an optical system capable of transporting the light over a large distance out of the harsh environment near the target to a lower radiation area where it is possible to operate a camera to capture this light. The monitor measures the proton beam position and width with a precision of better than 500 {\mu}m, meeting the physics requirements of the T2K experiment., Comment: 17 pages, 21 figures, Submitted to NIM A

Published
2012
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5. Exploring Service Learning Outcomes in Students: A Mixed Methods Study for Nursing

Author

Martin, John F.

Abstract

This mixed methods study exploring student outcomes of service learning experiences is inter-disciplinary, near the intersection of higher education research, moral development, and nursing. The specific problem examined in this study is that service learning among university students is utilized by educators, but largely without a full understanding of its effect upon students. The purpose of this mixed-methods study was to explore the change in affective rather than cognitive personal development characteristics pertaining to moral orientation and caring within nursing students following a service learning experience. The study consisted of a mixed methods approach, using a pre-test/post-test design for the quantitative portion of the study and interviews with students after they experience their service learning assignment in nursing within the qualitative part of the study. The research encompassed pre-post survey responses of nursing students from multiple campuses, before and after a clinical nursing service learning experience. In addition to survey responses, the data collected included focused interviews with students following their service learning experiences. The study drew theoretical foundations from two theories in the fields of nursing and moral development. The statistical analysis of survey findings, along with the qualitative analysis of rich and thick data emerging from the student interviews, revealed that when students have clinical experiences in the context of community service or public health, with an opportunity for reflection, they feel a growing sense of competency in nursing and confidence in finding their professional voice. Recommendations were made for sharpening the practice of service learning. More extensive and robust quantitative studies, some requiring funding, are needed to exceed purely isolated case studies and to ascertain outcomes across a more generalized population. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://www.proquest.com/en-US/products/dissertations/individuals.shtml.]

Published
2017

21. A theory of rapid evolutionary change explaining the de novo appearance of megakaryocytes and platelets in mammals

Author

Martin, John F, D'Avino, Paolo Pier, D'Avino, Paolo Pier [0000-0002-4773-6950], and Apollo - University of Cambridge Repository

Subjects
Platelets, Polyploidy, Blood Platelets, Mammals, Evolution, Animals, Megakaryocytes, Hemostatics, Cytokinesis
Abstract

Platelets are found only in mammals. Uniquely, they have a log Gaussian volume distribution and are produced from megakaryocytes, large cells that have polyploid nuclei. In this Hypothesis, we propose that a possible explanation for the origin of megakaryocytes and platelets is that, ∼220 million years ago, an inheritable change occurred in a mammalian ancestor that caused the haemostatic cell line of the animal to become polyploid. This inheritable change occurred specifically in the genetic programme of the cell lineage from which the haemostatic cell originated and led, because of increase in cell size, to its fragmentation into cytoplasmic particles (platelets) in the pulmonary circulatory system, as found in modern mammals. We hypothesize that these fragments originating from the new large haemostatic polyploid cells proved to be more efficient at stopping bleeding, and, therefore, the progeny of this ancestor prospered through natural selection. We also propose experimental strategies that could provide evidence to support this hypothesis.

Published
2022

22. Global Overview of the Transnational Alliance for Regenerative Therapies in Cardiovascular Syndromes (TACTICS) Recommendations: A Comprehensive Series of Challenges and Priorities of Cardiovascular Regenerative Medicine

Author

Fernández-Avilés, Francisco, Sanz-Ruiz, Ricardo, Climent, Andreu M., Badimon, Lina, Bolli, Roberto, Charron, Dominique, Fuster, Valentin, Janssens, Stefan, Kastrup, Jens, Kim, Hyo-Soo, Lüscher, Thomas F., Martin, John F., Menasché, Philippe, Pinto, Fausto J., Simari, Robert D., Stone, Gregg W., Terzic, Andre, Willerson, James T., and Wu, Joseph C.

Published
2018
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24. The Goal of Long Division

Author

Martin, John F.

Abstract

The advance of technology has caused many educators to question the time and energy expended for students to master the pencil-and-paper computation skills embodied in the long-division algorithm. In today's world, this mastery is truly a questionable goal. But understanding the conceptual infrastructure of the algorithm will add to students technological proficiency. The purpose of this article is to help readers reflect on the conceptual meaning buried within the division algorithm and to see how this understanding connects to students' prior knowledge. (Contains 1 table and 2 figures.)

Published
2009

26. The Derby Scheme and the Hinckley Local Military Service Tribunal During the First World War

Author

Martin, John F and King, Robert

Abstract

Transactions of the Leicestershire Archaeological and Historical Society, 91, 151-166, This article explores the transition of military service from the principle of individualism, whereby each individual operated on a self-reliant basis and made their own choices; to collectivism as represented by the Derby Scheme and Local Tribunals, whereby individuals were subjected to group decisions. Some historians would argue that it was a shift from volunteerism to collectivism which took place.

Published
2022
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27. The Emergence and Functioning of District Relief Committees during the First World War: A Case Study of Hinckley, Leicestershire

Author

Martin, John F and King, Robert

Abstract

Transactions of the Leicestershire Archaeological and Historical Society, 90, 215-244, Very little is known about the operation of the District Relief Committee (DRC) and the role it played during the First World War. This article undertakes a pioneering investigation into its significance by means of a case study of the DRC as it operated in the town of Hinckley, Leicestershire, and which demonstrated the unsung role that the organisation played in mobilising and coordinating the war effort at a local level. An important discovery was that over time the committee evolved from a charitable organisation, run by local dignitaries and personalities, from the onset of the war to, by 1916, a professionally operated de facto local government department. The effect of this largely unknown network, which has merited scant attention from historians, was to enable the government both rapidly to acquire and disseminate local information vital to the war effort, with the provision of aniline dyes being one such example.

Published
2022
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30. Peptides Derived from Vascular Endothelial Growth Factor B Show Potent Binding to Neuropilin‐1

Author

Mota, Filipa, primary, Yelland, Tamas, additional, Hutton, Jennie A., additional, Parker, Jennifer, additional, Patsiarika, Anastasia, additional, Chan, A. W. Edith, additional, O'Leary, Andrew, additional, Fotinou, Constantina, additional, Martin, John F., additional, Zachary, Ian C., additional, Djordjevic, Snezana, additional, Frankel, Paul, additional, and Selwood, David L., additional

Published
2021
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40. Female genital cutting and mother's age at birth are associated with the sex of offspring in Africa

Author

Martin, John F. and Williams, Robert C.

Subjects
Female circumcision, Biological sciences, Sociology and social work
Abstract

Female genital cutting (FGC) is widespread in Africa. Its short and long term medical consequences are widely reported. Here we report that FGC is associated with and may contribute to increases in the sex ratio at birth (Odds Ratio = 1.019; 95% C.I. = 1.007, 1.032) while mother's age at birth is inversely associated with probability of male birth (Odds Ratio = 0.998; 95% C.I. = 0.997, 0.999) in a generalized linear, logistic model with the probability of a male birth the dependent variable and eight potential explanatory variables applied to 413,384 births in 22 African countries. While these two associations are statistically significant, their odds ratios are close to 1.0 and they only slightly decrease the null deviance of the model. Therefore sex determination in these data is still a mostly stochastic process determined by the random variation in X or Y sperm production, transport, and conception.

Published
2008

41. Ammonium tetrathiomolybdate following ischemia/reperfusion injury: Chemistry, pharmacology, and impact of a new class of sulfide donor in preclinical injury models

Author

Dyson, Alex, Dal-Pizzol, Felipe, Sabbatini, Giovanni, Lach, Anna B., Galfo, Federica, dos Santos Cardoso, Juliano, Pescador Mendonça, Bruna, Hargreaves, Iain, Bollen Pinto, Bernardo, Bromage, Daniel I., Martin, John F., Moore, Kevin P., Feelisch, Martin, and Singer, Mervyn

Subjects
Molybdenum compounds -- Physiological aspects -- Usage, Reperfusion injury -- Care and treatment, Biological sciences
Abstract

Background Early revascularization of ischemic organs is key to improving outcomes, yet consequent reperfusion injury may be harmful. Reperfusion injury is largely attributed to excess mitochondrial production of reactive oxygen species (ROS). Sulfide inhibits mitochondria and reduces ROS production. Ammonium tetrathiomolybdate (ATTM), a copper chelator, releases sulfide in a controlled and novel manner, and may offer potential therapeutic utility. Methods and findings In vitro, ATTM releases sulfide in a time-, pH-, temperature-, and thiol-dependent manner. Controlled sulfide release from ATTM reduces metabolism (measured as oxygen consumption) both in vivo in awake rats and ex vivo in skeletal muscle tissue, with a superior safety profile compared to standard sulfide generators. Given intravenously at reperfusion/resuscitation to rats, ATTM significantly reduced infarct size following either myocardial or cerebral ischemia, and conferred survival benefit following severe hemorrhage. Mechanistic studies (in vitro anoxia/reoxygenation) demonstrated a mitochondrial site of action (decreased MitoSOX fluorescence), where the majority of damaging ROS is produced. Conclusions The inorganic thiometallate ATTM represents a new class of sulfide-releasing drugs. Our findings provide impetus for further investigation of this compound as a novel adjunct therapy for reperfusion injury., Author(s): Alex Dyson 1,2, Felipe Dal-Pizzol 1,3, Giovanni Sabbatini 1, Anna B. Lach 1,2, Federica Galfo 1,4, Juliano dos Santos Cardoso 3, Bruna Pescador Mendonça 3, Iain Hargreaves 5, Bernardo [...]

Published
2017
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46. Single cell transcriptional characterization of human megakaryocyte lineage commitment and maturation

Author

Choudry, Fizzah A, primary, Bagger, Frederik Otzen, additional, Macaulay, Iain C, additional, Farrow, Samantha, additional, Burden, Frances, additional, Kempster, Carly, additional, McKinney, Harriet, additional, Olsen, Lars R, additional, Huang, Ni, additional, Downes, Kate, additional, Voet, Thierry, additional, Uppal, Rakesh, additional, Martin, John F, additional, Mathur, Anthony, additional, Ouwehand, Willem H, additional, Laurenti, Elisa, additional, Teichmann, Sarah A, additional, and Frontini, Mattia, additional

Published
2020
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47. Single Cell Transcriptional Characterization of Human Megakaryocyte Lineage Commitment and Maturation

Author

Choudry, Fizzah, primary, Bagger, Frederik Otzen, additional, Macaulay, Iain C., additional, Farrow, Samatha, additional, Burden, Frances, additional, Kempster, Carly, additional, McKinney, Harriet, additional, Olsen, Lars R., additional, Huang, Ni, additional, Downes, Kate, additional, Voet, Thierry, additional, Uppal, Rakesh, additional, Martin, John F., additional, Mathur, Anthony, additional, Ouwehand, Willem H., additional, Laurenti, Elisa, additional, Teichmann, Sarah, additional, and Frontini, Mattia, additional

Published
2020
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