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Although the diagnostic techniques of medical biotechnology are being applied in Mexico, there is still a significant percentage of people who do not have access to health services, a result of the country's economic inequality. This article aims to present the impact in Mexico of several diseases (COVID-19, acute diarrheal disease, cervical cancer, breast cancer, leishmaniasis, acute kidney injury and neurocysticercosis), the strategies implemented in their diagnosis and control, as well as perspectives of novel diagnostic tests. The article was conducted through a review of online documents from the Mexican government and scientific articles that study the implementation and characteristics of biotechnological tools for disease diagnosis. In the case of COVID-19, the availability of accurate and rapid procedures for its diagnosis has proven to be of vital importance in the control of this disease, as well as in the understanding of infection and immunity processes. In the case of acute diarrheal disease resulting from rotavirus infection, the high morbidity and mortality of diseases cannot be completely controlled until the quality of life of the population is improved. The tools of biotechnology in diagnostics applied through public programs to vulnerable populations provide a way to close the health gap between developed and developing areas. Even so, it must be considered that the amount of resources they use is still high., Aunque las últimas técnicas de diagnóstico de la biotecnología médica son aplicadas en México, existe aún un porcentaje importante de personas que no tienen acceso a servicios de salud, resultado de la desigualdad económica en el país. Este artículo tiene como objetivo presentar el impacto en México de diversas enfermedades (COVID-19, enfermedad diarreica aguda, cáncer cervicouterino, cáncer de mama, leishmaniasis, lesiones renales agudas y neurocisticercosis), las estrategias implementadas en su diagnóstico y control, así como las perspectivas de pruebas de diagnóstico novedosas. El artículo se realizó a través de una revisión de documentos en línea del Gobierno mexicano y de artículos científicos que estudian la implementación y las características de las herramientas biotecnológicas para el diagnóstico de enfermedades. En el caso de la COVID-19, la disponibilidad de procedimientos certeros y rápidos para su diagnóstico ha demostrado ser de vital importancia en el control de la enfermedad, así como en el entendimiento de la infección y los procesos de inmunidad. En el caso de la enfermedad diarreica aguda derivada de la infección por rotavirus, la elevada morbilidad y mortalidad de enfermedades no puede ser completamente controlada hasta que mejore la calidad de vida de la población. Las herramientas de la biotecnología para el diagnóstico, aplicadas por medio de programas públicos dirigidos a la población vulnerable, proporcionan una forma de cerrar la brecha de salud entre zonas desarrolladas y en vías de desarrollo. Aun así, se debe considerar que la cantidad de recursos que se utilizan sigue siendo elevada.

Despite significant efforts to improve pancreatic ductal adenocarcinoma (PDAC) clinical outcomes, overall survival remains dismal. The poor response to current therapies is partly due to the existence of pancreatic cancer stem cells (PaCSCs), which are efficient drivers of PDAC tumorigenesis, metastasis and relapse. To find new therapeutic agents that could efficiently kill PaCSCs, we screened a chemical library of 680 compounds for candidate small molecules with anti-CSC activity, and identified two compounds of a specific chemical series with potent activity in vitro and in vivo against patient-derived xenograft (PDX) cultures. The anti-CSC mechanism of action of this specific chemical series was found to rely on induction of lysosomal membrane permeabilization (LMP), which is likely associated with the increased lysosomal mass observed in PaCSCs. Using the well characterized LMP-inducer siramesine as a tool molecule, we show elimination of the PaCSC population in mice implanted with tumors from two PDX models. Collectively, our approach identified lysosomal disruption as a promising anti-CSC therapeutic strategy for PDAC.

En esta investigación cuantitativa, descriptiva con método explicativo - correlacional y de corte transversal, se observó e identificó cómo se relacionan las variables de autoeficacia, estrés y agencia en el docente joven, con sus prácticas encaminadas a la prevención de los problemas de convivencia en el aula. Esto a partir de lo propuesto por la Teoría Social Cognitiva de Bandura, y los aportes de Chaux (2003) entre otros, donde se enfatiza en la interacción de los factores personales, situacionales (ambientales) y conductuales que pueden llegar a interferir en la eficacia del docente para el manejo de problemas de convivencia en el aula. Para ello, se examina, la relación entre la práctica docente en el aula y la prevención de los problemas de convivencia. Los resultados indican la existencia de relaciones significativas entre algunas de las variables del estudio, específicamente entre algunas de las dimensiones que las componen. Al final se discuten los resultados y sus implicaciones., In this Quantitative explanatory - descriptive and correlational, Cross-sectional research it was observe and identified how is characterized the relationship between the variables of selfefficacy, stress and agency on the young teachers with teaching practices that are aimed at preventing the coexistences problems in the high-school classroom. This is based on what was proposed by Bandura’s Social Cognitive Theory, and the contributions of Chaux (2003) among others, where relevance is given to the interaction of personal, situational (environmental) and behavioral factors that may could interfere in the system and teacher effectiveness for handling coexistence problems in the classroom. To do this, it was examined the relationship between teacher classroom practices and preventing the problems of coexistence. The results show that it does exist some meaningful relationships between the study variables, specifically between their internal dimensions. At the end it is been discussed the results and also its implications.