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Community-based participatory media projects form a promising new strategy for mental health promotion that can help address the mental health-gap identified by the World Health Organization. (2008b) mhGAP, Mental Health Gap Action Programme: Scaling Up Care for Mental, Neurological and Substance Use Disorders. World Health Organization, Geneva. In this article we present an ethnographic study about a participatory media project that was developed to promote mental health in selected Dutch low socio-economic status neighborhoods. Through narrowcastings (group film viewings), participant observation and interviews we mapped the ways in which the media project effected and facilitated the collective sense-making process of the audience with regard to sources of stress impacting mental health and opportunities for action. These determinants of mental health are shaped by cultural dimensions, since the cultural context shapes everyday experiences of stress as well as the resources and skills to manage them. Our analysis shows that the media project engaged cultural resources to challenge stressful social scripts. We conclude that more attention should be paid to cultural narratives in a community to understand how health promotion strategies can support social resilience.

Increases in incidents involving so-called confused persons have brought attention to the potential costs of recent changes to public mental health (PMH) services in the Netherlands. Decentralized under the (Community) Participation Act (2014), local governments must find resources to compensate for reduced central funding to such services or "innovate." But innovation, even when pressure for change is intense, is difficult.This perspective paper describes experience during and after an investigation into a particularly violent incident and murder. The aim was to provide recommendations to improve the functioning of local PMH services. The investigation concluded that no specific failure by an individual professional or service provider facility led to the murder. Instead, also as a result of the Participation Act that severed communication lines between individuals and organizations, information sharing failures were likely to have reduced system level capacity to identify risks. The methods and analytical frameworks employed to reach this conclusion, also lead to discussion as to the plausibility of an unconventional solution. If improving communication is the primary problem, non-hierarchical information, and organizational networks arise as possible and innovative system solutions.The proposal for debate is that traditional "health system" definitions, literature and narratives, and operating assumptions in public (mental) health are 'locked in' constraining technical and organization innovations. If we view a "health system" as an adaptive system of economic and social "networks," it becomes clear that the current orthodox solution, the so-called integrated health system, typically results in a "centralized hierarchical" or "tree" network. An overlooked alternative that breaks out of the established policy narratives is the view of a 'health systems' as a non-hierarchical organizational structure or 'Open Network.' In turn, this opens new technological and organizational possibilities in seeking policy solutions, and suggests an alternative governance model of huge potential value in public health both locally and globally.

This article offers a critical analysis of how to address social inequalities in mental health. In public mental health, inequalities are commonly construed as a problem of reach, implying that existing mental health expertise often fails to reach low-income groups. We discuss two critiques on the ‘reach-paradigm’ in mental health promotion: the impoverishment of idioms of distress and the tendency to transform complex political issues into clinical ones that are assumed to be backed by evidence. Furthermore, we present the findings of our ethnographic research of an alternative approach to mental health promotion that used media storytelling focused on local knowledge and social context. Our analysis is guided by anthropological research on idioms of distress and sociological literature on health promotion and social inequalities.

Most of the street-based children are not educated beyond primary school and their living conditions are based on begging and doing odd jobs in the market and streets. Forty-six percent of the on-the-street children live with one parent, and 97 percent of the of-the-street children have lost contact with their parents. The on-the-street children have a higher percentage of family sector networks than the of-the-street children and the shelter or institutionalized children. Generally, school children still have strong family ties.

The context in which Bediüzzaman Said Nursi wrote the first version of his now famous Damascus sermon was a meeting on a continent and in an age in which Muslims were being forced to reflect on their identity due to negative interaction with non-Muslims.Meanwhile, the relationships between Muslims and non-Muslims have changed drastically. Nonetheless, not only Muslims but also Christians and even Muslims and Christians together in dialogue now have more rather than fewer reasons to be concerned about the question of how they, based on their authentic religious values, can contribute to a good society.Even the mid-20th century Turkish revision of the Damascus sermon is dated. The document does, however, offer a clarifying template that can still be highly beneficial for Muslims and Christians a century later in striving for what is beneficial for themselves and their environment while keeping their own identities in mind.Christians could also acknowledge a great deal in the six ailments and remedies the healer identifies in the “Six Words.” At the same time, it suits the spirit of the age to proceed not only via a set of major resemblances between both religions but also mutatis mutandis in connection with what is typical for each religion. As a Christian, I would like to flesh this out with “hope,” “faithfulness,” “love,” “unity,” “dignity,” and “consultation,” based on my faith, of which Jesus Christ is the centre.The challenge of today’s and tomorrow’s globalised reality that Muslims and Christians have to cope with is, for instance, to formulate a new Purifying paradigm based on the concepts listed by Nursi, designed to be fully respective of the well understood uniqueness of the other. Christian acceptance of Muslims should not depend on the extent to which they are integrated into Western society, nor should Christians be viewed by Muslims as pre-Muslims.This challenge goes further and is more difficult than striving to come to “a common word”: in fact, we will need to understand a variety of words. But if the efforts are crowned with success, this is a more valid way for Muslims and Christians - who together make up the majority of the world’s population - to be a good example for society.From a Christian point of view and that of the 20th century’s disenchantment, Nursi is overly optimistic when he suggests society can be affected by implementing religious values. Religious people and non-religious people alike in the current demographic will continue to co-exist and individually suffer from the cited and notcited maladies, and this was no different in the golden eras of yore.Nevertheless, we can point to signs of hope when we succeed together in resolving the dilemma of right-wing capitalism and liberalism on the one hand and left-wing communism and socialism on the other by means of our own religiously motivated values to allow Christians, Muslims, and others to sample a bit of the future heaven on earth.

In T-cell Acute Lymphocytic Leukemia (T-ALL), the inhibitors of cyclin-dependent kinases (CDK) 4 and 6, p16 and p15, are inactivated almost universally at the DNA, RNA and protein levels. This suggests that CDK-targeting may be an effective therapeutic approach for T-ALL and other cancers. In this study, we tested 3 inhibitors of CDK4, 3-aminothioacridone (3-ATA), thioacridone (TA), and oxindole, for their effects on DNA synthesis and viability in primary T-ALL. Each compound was an effective inhibitor, with overall IC(50)s in similar ranges. In colony formation assay, leukemic cells were approximately 10-fold more sensitive to 3-ATA than normal bone marrow cells. When sorted by G1 protein status of T-ALL, p16(+), p15(+) or pRb(-) samples were significantly less sensitive to 3-ATA and TA, but not to oxindole, than p16(-), p15(-) or pRb(+) samples. There was no relationship of sensitivity with ARF expression. Despite their in vitro function as inhibitors of CDK4, 3-ATA did not inhibit pRb phosphorylation or cause G1 arrest, but did cause DNA damage and result in the induction and phosphorylation of p53. We conclude that 3-ATA efficacy can be predicted by p16 status in T-ALL, but the mechanism of action may be distinct from their in vitro ability to regulate CDK4 kinase activity

Street children are a high priority for health policy and service planning in Kenya. Poverty, wars, famine and disease have resulted in street children having a persistent presence in African cities and towns. The Maastricht Social Network Analysis (MSNA) was implemented as the core instrument in a battery to measure the health status of the street children. Owing to the absence of census data of street children in Kenya and the difficulty in tracking this mobile population, we implemented a mixed snowball and convenience sampling design to recruit research subjects. Three hundred street and orphanage children, and 100 primary school children as a control group, were included in the study. The MSNA provided a social diagnosis that complements the clinical diagnosis of the health status of the sample. Only one main methodological question is presented: is the MSNA applicable to describe the personal social networks of (1). children and of (2). people living in a Kenyan culture? Qualitative field observations, key informant interviews and focus groups inform the adaptation of the MSNA instrument, and improve its face validity. A case series analysis is presented. The main result is that the street children population consists of distinct subgroups defined by the UNICEF classification as 'on' and 'of' the street and by gender. Street children networks have some notable deficiencies depending on the subgroup. Constant across the groups is the deficiency of service providers in their networks. The conclusion is that the MSNA is a suitable instrument for obtaining a social diagnosis and gathering other useful information that helps in understanding the social and health backgrounds, status and daily experiences of Kenyan scavenging street children. Applying the MSNA protocol was successful in the diagnosis and interpretation of the findings.

Etats, syndromes et classes polythétiques: l'opérationalisation de l'analyse de classifications croisées dans la recherche dans les sciences du comportement. Par une analyse détaillée de la notion de classification et de la nomenclature de certains problèmes du comportement, les auteurs affinent les concepts de syndrome, de classe, de modèle et de type idéal, tout en précisant les relations étroites entre eux. La méthode de classifications croisées fournit un moyen d'opérationalisation de ces considérations. L'échantillonage d'expériences (ES), qui introduit des variables d'état mental et d'environnement immédiat, fournit un nouvel instrument de recherche. Ensemble ces développements constituent la méthodologie de recherche actuellement employée dans deux programmes importants de recherche sur le comportement: un sur l'anxiété, l'autre sur l'utilisation des drogues. La combinaison de ces deux techniques met en lumière des aspects nouveaux de la relation entre syndromes, analyse et modèles.