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3. Clinical factors associated with death in 3044 COVID-19 patients managed in internal medicine wards in Italy: results from the SIMI-COVID-19 study of the Italian Society of Internal Medicine (SIMI)

Author

Corradini, E., Ventura, P., Ageno, W., Cogliati, C. B., Muiesan, M. L., Girelli, Davide Nicola, Pirisi, M., Gasbarrini, Antonio, Angeli, P., Querini, P. R., Bosi, E., Tresoldi, M., Vettor, R., Cattaneo, M., Piscaglia, F., Brucato, A. L., Perlini, S., Martelletti, P., Pontremoli, R., Porta, M., Minuz, P., Olivieri, O., Sesti, G., Biolo, G., Rizzoni, D., Serviddio, G., Cipollone, F., Grassi, D., Manfredini, R., Moreo, G. L., Pietrangelo, A., Teatini, T., Salvetti, Maria Cristina, Crisafulli, E., Sainaghi, Pier Paolo, Zileri Dal Verme, Lorenzo, Piano, S., De Lorenzo, R., Arcidiacono, G., Podda, Maria Vittoria, Muratori, L., Gabiati, C., Salinaro, F., Luciani, Massimiliano, Barnini, C., Morra di Cella, S., Dalbeni, A., Friso, S., Mearelli, F., Malerba, P., Cavallone, F., D'Ardes, D., Notargiacomo, S., De Giorgi, A., Mansi, M., Buzzetti, E., Ricci, A., Martelli, Franco, Girelli D., Gasbarrini A. (ORCID:0000-0002-7278-4823), Salvetti M., Sainaghi P. P., Zileri Dal Verme L., Podda M. (ORCID:0000-0002-2779-8417), Luciani M., Martelli F., Corradini, E., Ventura, P., Ageno, W., Cogliati, C. B., Muiesan, M. L., Girelli, Davide Nicola, Pirisi, M., Gasbarrini, Antonio, Angeli, P., Querini, P. R., Bosi, E., Tresoldi, M., Vettor, R., Cattaneo, M., Piscaglia, F., Brucato, A. L., Perlini, S., Martelletti, P., Pontremoli, R., Porta, M., Minuz, P., Olivieri, O., Sesti, G., Biolo, G., Rizzoni, D., Serviddio, G., Cipollone, F., Grassi, D., Manfredini, R., Moreo, G. L., Pietrangelo, A., Teatini, T., Salvetti, Maria Cristina, Crisafulli, E., Sainaghi, Pier Paolo, Zileri Dal Verme, Lorenzo, Piano, S., De Lorenzo, R., Arcidiacono, G., Podda, Maria Vittoria, Muratori, L., Gabiati, C., Salinaro, F., Luciani, Massimiliano, Barnini, C., Morra di Cella, S., Dalbeni, A., Friso, S., Mearelli, F., Malerba, P., Cavallone, F., D'Ardes, D., Notargiacomo, S., De Giorgi, A., Mansi, M., Buzzetti, E., Ricci, A., Martelli, Franco, Girelli D., Gasbarrini A. (ORCID:0000-0002-7278-4823), Salvetti M., Sainaghi P. P., Zileri Dal Verme L., Podda M. (ORCID:0000-0002-2779-8417), Luciani M., and Martelli F.

Abstract

During the COVID-19 2020 outbreak, a large body of data has been provided on general management and outcomes of hospitalized COVID-19 patients. Yet, relatively little is known on characteristics and outcome of patients managed in Internal Medicine Units (IMU). To address this gap, the Italian Society of Internal Medicine has conducted a nationwide cohort multicentre study on death outcome in adult COVID-19 patients admitted and managed in IMU. This study assessed 3044 COVID-19 patients at 41 referral hospitals across Italy from February 3rd to May 8th 2020. Demographics, comorbidities, organ dysfunction, treatment, and outcomes including death were assessed. During the study period, 697 patients (22.9%) were transferred to intensive care units, and 351 died in IMU (death rate 14.9%). At admission, factors independently associated with in-hospital mortality were age (OR 2.46, p = 0.000), productive cough (OR 2.04, p = 0.000), pre-existing chronic heart failure (OR 1.58, p = 0.017) and chronic obstructive pulmonary disease (OR 1.17, p = 0.048), the number of comorbidities (OR 1.34, p = 0.000) and polypharmacy (OR 1.20, p = 0.000). Of note, up to 40% of elderly patients did not report fever at admission. Decreasing PaO2/FiO2 ratio at admission was strongly inversely associated with survival. The use of conventional oxygen supplementation increased with the number of pre-existing comorbidities, but it did not associate with better survival in patients with PaO2/FiO2 ratio < 100. The latter, significantly benefited by the early use of non-invasive mechanical ventilation. Our study identified PaO2/FiO2 ratio at admission and comorbidity as the main alert signs to inform clinical decisions and resource allocation in non-critically ill COVID-19 patients admitted to IMU.

Published
2021

9. AFM characterization of rabbit spermatozoa

Author

Ierardi, Vincenzo, Niccolini, Alberto, Alderighi, Michele, Gazzano, Angelo, Martelli, Franco, Solaro, Roberto, Vol, PP IN PRESS, and Pag, T. O. T.

Subjects
Male, Ejaculated spermatozoa, plasmatic membrane, Histology, Materials science, Morphology (linguistics), rabbit, AFM, rabbit spermatozoa, cell morphology, Cell morphology, Microscopy, Atomic Force, Image Processing, Computer-Assisted, Animals, Acrosome, Instrumentation, Cell Size, Atomic force microscopy, Rabbit (nuclear engineering), Spermatozoa, Characterization (materials science), Plasmatic membrane, Medical Laboratory Technology, Crystallography, Rabbits, Anatomy, spermatozoa
Abstract

Atomic force microscopy (AFM) has been applied for determining the topological and structural features of rabbit spermatozoa. Fresh ejaculated spermatozoa were adsorbed pas- sively onto a silicon slide or by motility from suspension onto a poly(L-lysine)-coated glass coverslip and then imaged in air and in buffer saline, respectively. AFM images clearly highlighted many details of spermatozoa head, neck, and tail. Distinct features were observed in the plasmatic mem- brane of spermatozoa. In particular, head topography easily recognized the acrosome, equatorial segment, equatorial subsegment, and postacrosome regions. Moreover, AFM images revealed the presence of double belt of invaginations around the spermatozoa head, at the boundary between equatorial subsegment and postacrosome regions. All together, the collected AFM images clearly defined a detailed map of spermatozoa morphology while giving some hints on the internal struc- ture. Microsc. Res. Tech. 71:529-535, 2008. V C 2008 Wiley-Liss, Inc.

Published
2008

42. Coenzyme Q10 and vitamin E in human semen

Author

Martelli, Franco, Gazzano, Angelo, Voliani, S., Niccolini, A., Rossi, P., Lemmi, C., Barsacchi, R., Sighieri, Claudio, Ducci, M., and MENCHINI FABRIS, F.

Subjects
Coenzyme Q10 - vitamin E - human semen
Published
2003

49. Coenzyme Q10 levels in human follicular fluid

Author

Gazzano, Angelo, Artini, PAOLO GIOVANNI, Niccolini, Alberto, Sighieri, Claudio, Martelli, Franco, and Ducci, Michele

Subjects
Coenzyme Q10 - human follicular fluid, Coenzyme Q10 - follicular fluid - human
Published
2002

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