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1,168 results on '"Martel-Pelletier, J."'

3. Alternative and complementary therapies in osteoarthritis and cartilage repair

Author

Fuggle, N. R., Cooper, C., Oreffo, R. O. C., Price, A. J., Kaux, J. F., Maheu, E., Cutolo, M., Honvo, G., Conaghan, P. G., Berenbaum, F., Branco, J., Brandi, M. L., Cortet, B., Veronese, N., Kurth, A. A., Matijevic, R., Roth, R., Pelletier, J. P., Martel-Pelletier, J., Vlaskovska, M., Thomas, T., Lems, W. F., Al-Daghri, N., Bruyère, O., Rizzoli, R., Kanis, J. A., and Reginster, J. Y.

Published
2020
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4. OARSI Clinical Trials Recommendations: Hip imaging in clinical trials in osteoarthritis

Author

Gold, GE, Cicuttini, F, Crema, MD, Eckstein, F, Guermazi, A, Kijowski, R, Link, TM, Maheu, E, Martel-Pelletier, J, Miller, CG, Pelletier, J-P, Peterfy, CG, Potter, HG, Roemer, FW, and Hunter, DJ

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Biomedical Imaging, Clinical Research, Aging, Arthritis, Musculoskeletal, Clinical Trials as Topic, Diagnostic Imaging, Disease Progression, Humans, Osteoarthritis, Hip, Practice Guidelines as Topic, Clinical trial guidelines, Hip osteoarthritis, Imaging, Biomedical Engineering, Human Movement and Sports Sciences, Arthritis & Rheumatology, Clinical sciences, Sports science and exercise
Abstract

Imaging of hip in osteoarthritis (OA) has seen considerable progress in the past decade, with the introduction of new techniques that may be more sensitive to structural disease changes. The purpose of this expert opinion, consensus driven recommendation is to provide detail on how to apply hip imaging in disease modifying clinical trials. It includes information on acquisition methods/techniques (including guidance on positioning for radiography, sequence/protocol recommendations/hardware for magnetic resonance imaging (MRI)); commonly encountered problems (including positioning, hardware and coil failures, artifacts associated with various MRI sequences); quality assurance/control procedures; measurement methods; measurement performance (reliability, responsiveness, and validity); recommendations for trials; and research recommendations.

Published
2015

16. Single nucleotide polymorphism genes and mitochondrial DNA haplogroups as biomarkers for early prediction of knee osteoarthritis structural progressors: use of supervised machine learning classifiers.

Author

Bonakdari, H, Pelletier, J-P, Blanco, FJ, Rego-Pérez, I, Durán-Sotuela, A, Aitken, D, Jones, G, Cicuttini, F, Jamshidi, A, Abram, F, Martel-Pelletier, J, Bonakdari, H, Pelletier, J-P, Blanco, FJ, Rego-Pérez, I, Durán-Sotuela, A, Aitken, D, Jones, G, Cicuttini, F, Jamshidi, A, Abram, F, and Martel-Pelletier, J

Abstract

BACKGROUND: Knee osteoarthritis is the most prevalent chronic musculoskeletal debilitating disease. Current treatments are only symptomatic, and to improve this, we need a robust prediction model to stratify patients at an early stage according to the risk of joint structure disease progression. Some genetic factors, including single nucleotide polymorphism (SNP) genes and mitochondrial (mt)DNA haplogroups/clusters, have been linked to this disease. For the first time, we aim to determine, by using machine learning, whether some SNP genes and mtDNA haplogroups/clusters alone or combined could predict early knee osteoarthritis structural progressors. METHODS: Participants (901) were first classified for the probability of being structural progressors. Genotyping included SNP genes TP63, FTO, GNL3, DUS4L, GDF5, SUPT3H, MCF2L, and TGFA; mtDNA haplogroups H, J, T, Uk, and others; and clusters HV, TJ, KU, and C-others. They were considered for prediction with major risk factors of osteoarthritis, namely, age and body mass index (BMI). Seven supervised machine learning methodologies were evaluated. The support vector machine was used to generate gender-based models. The best input combination was assessed using sensitivity and synergy analyses. Validation was performed using tenfold cross-validation and an external cohort (TASOAC). RESULTS: From 277 models, two were defined. Both used age and BMI in addition for the first one of the SNP genes TP63, DUS4L, GDF5, and FTO with an accuracy of 85.0%; the second profits from the association of mtDNA haplogroups and SNP genes FTO and SUPT3H with 82.5% accuracy. The highest impact was associated with the haplogroup H, the presence of CT alleles for rs8044769 at FTO, and the absence of AA for rs10948172 at SUPT3H. Validation accuracy with the cross-validation (about 95%) and the external cohort (90.5%, 85.7%, respectively) was excellent for both models. CONCLUSIONS: This study introduces a novel source of decision support in preci

Published
2022

17. Restricting Branched-Chain Amino Acids within a High-Fat Diet Prevents Obesity.

Author

Liu, M, Huang, Y, Zhang, H, Aitken, D, Nevitt, MC, Rockel, JS, Pelletier, J-P, Lewis, CE, Torner, J, Rampersaud, YR, Perruccio, AV, Mahomed, NN, Furey, A, Randell, EW, Rahman, P, Sun, G, Martel-Pelletier, J, Kapoor, M, Jones, G, Felson, D, Qi, D, Zhai, G, Liu, M, Huang, Y, Zhang, H, Aitken, D, Nevitt, MC, Rockel, JS, Pelletier, J-P, Lewis, CE, Torner, J, Rampersaud, YR, Perruccio, AV, Mahomed, NN, Furey, A, Randell, EW, Rahman, P, Sun, G, Martel-Pelletier, J, Kapoor, M, Jones, G, Felson, D, Qi, D, and Zhai, G

Abstract

Obesity is a global pandemic, but there is yet no effective measure to control it. Recent metabolomics studies have identified a signature of altered amino acid profiles to be associated with obesity, but it is unclear whether these findings have actionable clinical potential. The aims of this study were to reveal the metabolic alterations of obesity and to explore potential strategies to mitigate obesity. We performed targeted metabolomic profiling of the plasma/serum samples collected from six independent cohorts and conducted an individual data meta-analysis of metabolomics for body mass index (BMI) and obesity. Based on the findings, we hypothesized that restriction of branched-chain amino acids (BCAAs), phenylalanine, or tryptophan may prevent obesity and tested our hypothesis in a dietary restriction trial with eight groups of 4-week-old male C57BL/6J mice (n = 5/group) on eight different types of diets, respectively, for 16 weeks. A total of 3397 individuals were included in the meta-analysis. The mean BMI was 30.7 ± 6.1 kg/m2, and 49% of participants were obese. Fifty-eight metabolites were associated with BMI and obesity (all p ≤ 2.58 × 10-4), linked to alterations of the BCAA, phenylalanine, tryptophan, and phospholipid metabolic pathways. The restriction of BCAAs within a high-fat diet (HFD) maintained the mice's weight, fat and lean volume, subcutaneous and visceral adipose tissue weight, and serum glucose and insulin at levels similar to those in the standard chow group, and prevented obesity, adipocyte hypertrophy, adipose inflammation, and insulin resistance induced by HFD. Our data suggest that four metabolic pathways, BCAA, phenylalanine, tryptophan, and phospholipid metabolic pathways, are altered in obesity and restriction of BCAAs within a HFD can prevent the development of obesity and insulin resistance in mice, providing a promising strategy to potentially mitigate diet-induced obesity.

Published
2022

18. POS0231 GENETIC BIOMARKERS, SNP GENES AND mtDNA HAPLOGROUPS, PREDICT OSTEOARTHRITIS STRUCTURAL PROGRESSORS THROUGH THE USE OF SUPERVISED MACHINE LEARNING

Author

Bonakdari, H., primary, Pelletier, J. P., additional, Blanco, F. J., additional, Rego-Perez, I., additional, Durán-Sotuela, A., additional, Aitken, D., additional, Jones, G., additional, Cicuttini, F., additional, Jamshidi, A., additional, Abram, F., additional, and Martel-Pelletier, J., additional

Published
2022
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19. AB0994 Exploring knee osteoarthritis pain trajectories and movement-evoked pain changes during a 24-week outdoor walking program (WALK)

Author

Drummen, S., primary, Balogun, S., additional, Scheepers, L., additional, Munugoda, I., additional, Lahham, A., additional, Bennell, K., additional, Hinman, R., additional, Callisaya, M., additional, Cai, G., additional, Otahal, P., additional, Winzenberg, T., additional, Wang, Z., additional, Antony, B., additional, Martel-Pelletier, J., additional, Pelletier, J. P., additional, Abram, F., additional, Jones, G., additional, and Aitken, D., additional

Published
2022
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32. Automatic human knee cartilage segmentation from 3-D magnetic resonance images

Author

Dodin, P., Pelletier, J., Martel-Pelletier, J., and Abram, F.

Subjects
Cartilage -- Observations, Magnetic resonance imaging -- Analysis, Osteoarthritis -- Diagnosis, Radiography -- Usage, Knee -- Injuries, Knee -- Diagnosis, Biological sciences, Business, Computers, Health care industry
Published
2010

38. Alternative and complementary therapies in osteoarthritis and cartilage repair

Author

Fuggle, Nicholas, Cooper, Cyrus, Oreffo, Richard, Price, A.J., Kaux, J.F., Maheu, E., Cutolo, M., Honvo, G., Conaghan, P.G., Berenbaum, F., Branco, J., Brandi, M.L., Cortet, B., Veronese, N., Kurth, A.A., Matijevic, R., Roth, R., Pelletier, J.P., Martel-Pelletier, J., Vlaskovska, M., Thomas, T., Lems, W.F., Al-Daghri, N., Bruyere, O., Rizzoli, R., Kanis, J.A., and Reginster, J.Y.

Abstract

Osteoarthritis (OA) is the most common joint condition and, with a burgeoning ageing population, is due to increase in prevalence. Beyond conventional medical and surgical interventions, there are an increasing number of ‘alternative’ therapies. These alternative therapies may have a limited evidence base and, for this reason, are often only afforded brief reference (or completely excluded) from current OA guidelines. Thus, the aim of this review was to synthesize the current evidence regarding autologous chondrocyte implantation (ACI), mesenchymal stem cell (MSC) therapy, platelet-rich plasma (PRP), vitamin D and other alternative therapies. The majority of studies were in knee OA or chondral defects. Matrix-assisted ACI has demonstrated exceedingly limited, symptomatic improvements in the treatment of cartilage defects of the knee and is not supported for the treatment of knee OA. There is some evidence to suggest symptomatic improvement with MSC injection in knee OA, with the suggestion of minimal structural improvement demonstrated on MRI and there are positive signals that PRP may also lead to symptomatic improvement, though variation in preparation makes inter-study comparison difficult. There is variability in findings with vitamin D supplementation in OA, and the only recommendation which can be made, at this time, is for replacement when vitamin D is deplete. Other alternative therapies reviewed have some evidence (though from small, poor-quality studies) to support improvement in symptoms and again there is often a wide variation in dosage and regimens. For all these therapeutic modalities, although controlled studies have been undertaken to evaluate effectiveness in OA, these have often been of small size, limited statistical power, uncertain blindness and using various methodologies. These deficiencies must leave the question as to whether they have been validated as effective therapies in OA (or chondral defects). The conclusions of this review are that all alternative interventions definitely require clinical trials with robust methodology, to assess their efficacy and safety in the treatment of OA beyond contextual and placebo effects.

Published
2020

43. What is the predictive value of MRI for the occurrence of knee replacement surgery in knee osteoarthritis?

Author

Pelletier, J-P, Cooper, C, Peterfy, C, Reginster, J-Y, Brandi, M-L, Bruyère, O, Chapurlat, R, Cicuttini, F, Conaghan, P G, Doherty, M, Genant, H, Giacovelli, G, Hochberg, M C, Hunter, D J, Kanis, J A, Kloppenburg, M, Laredo, J-D, McAlindon, T, Nevitt, M, Raynauld, J-P, Rizzoli, R, Zilkens, C, Roemer, F W, Martel-Pelletier, J, and Guermazi, A

Published
2013
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