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1. Lesson in understanding parents’ perspective: perception of quality of care and COVID-19-related fears among users of paediatric health services over the COVID-19 pandemic in 11 facilities in Italy

Author

Egidio Barbi, Silvia Bressan, Stefano Masi, Marzia Lazzerini, Paola Cogo, Vanna Graziani, Federico Marchetti, Giorgio Cozzi, Ilaria Mariani, Ilaria Liguoro, Francesca Tirelli, Chiara Stefani, Sarah Contorno, Stefano Martelossi, Alessandro Amaddeo, Alessia Marcellino, Riccardo Lubrano, Enrico Felici, Annunziata Lucarelli, Gian Luca Trobia, Elia Balestra, Benmario Castaldo, Alice Del Colle, Chiara Pilotto, Paola Moras, Marcella Massarotto, Paola Crotti, Benedetta Ferro, Riccardo Pavanello, Silvia Fasoli, Chiara Grisaffi, Idanna Sforzi, Rosa Santangelo, Andrea Iuorio, Sara Dal Bo, Vanessa Martucci, Mariateresa Sanseviero, Roberta Parrino, Giuseppina de Rosa, Vita Antonella Di Stefano, Francesca Patané, Marta Minute, Fabio Cardinale, Alessandra Iacono, Alessandro Zago, Angela Troisi, Marta Arrabito, Paolo Dalena, Massimo Dagnelut, Maristella Toniutti, Silvia Galiazzo, Maria Luisa Casciana, Marta Gagliardi, Kevin Valentino, Lucia Grazia Tricarico, Mariateresa De Sario, Alessandra Pisani, Maria Carla Finocchiaro, Laura Portale, Marco Greco, Emiliano Talanti, Anna Madera, Paola Stillo, Nicolò Chiti, Silvia Bloise, Silvia Sordelli, Mariangela Labruzzo, Massimo Lo Verde, Domenico Cipolla, Carlotta Farneti, Francesco Oppido, Giulia Sansovini, Giada Sartor, Marta Magnolato, Michele Maiola, Michela Pandullo, and Sara Rivellini

Subjects
Pediatrics, RJ1-570
Abstract

Background The COVID-19 pandemic had an important psychological impact on children and their families. This study aims to explore paediatric health services users’ perceptions of quality of care (QOC) and COVID-19-related fears, and their evolution over time in relation to COVID-19 pandemic.Methods In a multicentre cross-sectional study involving 11 public hospitals providing paediatric care across the Italian territory, we collected data from services users through a validated questionnaire. We analysed four indicators—(1) QOC perceived in relation to COVID-19; (2) overall QOC perceived; (3) fear of accessing health services due to COVID-19; (4) fear of contracting COVID-19 in hospital—and calculated Spearman’s correlation indexes (ρ) with the number of COVID-19 new cases over time. Subgroup analyses were conducted by macroregions and single facility.Results Data from 956 services users were analysed. QOC indicators were stable over time at values close to the maximum (range 77–100 and median 100 for COVID-19 QOC, range 74–98 and median 80 for overall QOC), and no correlations were found with the COVID-19 new cases (ρ=−0.073 and −0.016, respectively). Fear of accessing care and fear of contracting the infection varied over time in between 0%–52% and 0%–53%, respectively, but did not correlate directly with number of COVID-19 new cases (ρ=0.101, 0.107 and 0.233, 0.046, respectively). At subgroup analyses, significantly higher frequencies of fear (p values

Published
2024
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2. Evaluation of the WHO standards to assess quality of care for children with acute respiratory infections: findings of a baseline multicentre assessment (CHOICE) in Italy

Author

Egidio Barbi, Silvia Bressan, Stefano Masi, Marzia Lazzerini, Paola Cogo, Vanna Graziani, Federico Marchetti, Giorgio Cozzi, Ilaria Mariani, Ilaria Liguoro, Francesca Tirelli, Chiara Stefani, Sarah Contorno, Stefano Martelossi, Alessandro Amaddeo, Alessia Marcellino, Riccardo Lubrano, Enrico Felici, Annunziata Lucarelli, Gian Luca Trobia, Elia Balestra, Benmario Castaldo, Alice Del Colle, Chiara Pilotto, Paola Moras, Marcella Massarotto, Paola Crotti, Benedetta Ferro, Riccardo Pavanello, Silvia Fasoli, Chiara Grisaffi, Idanna Sforzi, Rosa Santangelo, Andrea Iuorio, Sara Dal Bo, Vanessa Martucci, Mariateresa Sanseviero, Roberta Parrino, Giuseppina de Rosa, Vita Antonella Di Stefano, Francesca Patané, Marta Minute, Fabio Cardinale, Alessandra Iacono, Angela Troisi, Marta Arrabito, Paolo Dalena, Massimo Dagnelut, Maristella Toniutti, Silvia Galiazzo, Maria Luisa Casciana, Marta Gagliardi, Kevin Valentino, Lucia Grazia Tricarico, Mariateresa De Sario, Alessandra Pisani, Maria Carla Finocchiaro, Laura Portale, Marco Greco, Emiliano Talanti, Anna Madera, Paola Stillo, Nicolò Chiti, Silvia Bloise, Silvia Sordelli, Mariangela Labruzzo, Massimo Lo Verde, Domenico Cipolla, Carlotta Farneti, Francesco Oppido, Giulia Sansovini, Giada Sartor, Marta Magnolato, Michele Maiola, Michela Pandullo, and Sara Rivellini

Subjects
Pediatrics, RJ1-570
Published
2024
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3. Implementation of the WHO standards to assess the quality of care for children with acute diarrhoea: findings of a multicentre study (CHOICE) in Italy

Author

Egidio Barbi, Silvia Bressan, Stefano Masi, Marzia Lazzerini, Paola Cogo, Vanna Graziani, Federico Marchetti, Giorgio Cozzi, Ilaria Mariani, Valentina Baltag, Ilaria Liguoro, Francesca Tirelli, Chiara Stefani, Sarah Contorno, Stefano Martelossi, Alessandro Amaddeo, Alessia Marcellino, Riccardo Lubrano, Enrico Felici, Annunziata Lucarelli, Gian Luca Trobia, Elia Balestra, Benmario Castaldo, Alice Del Colle, Chiara Pilotto, Paola Moras, Marcella Massarotto, Paola Crotti, Benedetta Ferro, Riccardo Pavanello, Silvia Fasoli, Chiara Grisaffi, Idanna Sforzi, Rosa Santangelo, Andrea Iuorio, Vanessa Martucci, Mariateresa Sanseviero, Roberta Parrino, Giuseppina de Rosa, Francesca Patané, Marta Minute, Fabio Cardinale, Alessandra Iacono, Angela Troisi, Marta Arrabito, Paolo Dalena, Massimo Dagnelut, Maristella Toniutti, Silvia Galiazzo, Maria Luisa Casciana, Marta Gagliardi, Kevin Valentino, Lucia Grazia Tricarico, Mariateresa De Sario, Alessandra Pisani, Maria Carla Finocchiaro, Laura Portale, Marco Greco, Emiliano Talanti, Anna Madera, Paola Stillo, Nicolò Chiti, Silvia Bloise, Silvia Sordelli, Mariangela Labruzzo, Massimo Lo Verde, Domenico Cipolla, Carlotta Farneti, Francesco Oppido, Giulia Sansovini, Giada Sartor, Marta Magnolato, Michele Maiola, Michela Pandullo, Sara Rivellini, Sara Dal Bo, and Vita Antonella Di Stefano

Subjects
Pediatrics, RJ1-570
Published
2024
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4. Implementation of the WHO Standards to assess quality of paediatric care at the facility level using service users’ perspective as source of data: a multicentre quality improvement study in Italy

Author

Egidio Barbi, Silvia Bressan, Stefano Masi, Marzia Lazzerini, Paola Cogo, Vanna Graziani, Federico Marchetti, Giorgio Cozzi, Ilaria Mariani, Valentina Baltag, Ilaria Liguoro, Francesca Tirelli, Chiara Stefani, Sarah Contorno, Stefano Martelossi, Alessandro Amaddeo, Alessia Marcellino, Riccardo Lubrano, Enrico Felici, Annunziata Lucarelli, Gian Luca Trobia, Elia Balestra, Benmario Castaldo, Alice Del Colle, Chiara Pilotto, Paola Moras, Marcella Massarotto, Paola Crotti, Benedetta Ferro, Riccardo Pavanello, Silvia Fasoli, Chiara Grisaffi, Idanna Sforzi, Rosa Santangelo, Andrea Iuorio, Sara Dal Bo, Vanessa Martucci, Mariateresa Sanseviero, Roberta Parrino, Giuseppina de Rosa, Vita Antonella Di Stefano, Francesca Patané, Marta Minute, Fabio Cardinale, Alessandra Iacono, Angela Troisi, Marta Arrabito, Paolo Dalena, Massimo Dagnelut, Maristella Toniutti, Silvia Galiazzo, Maria Luisa Casciana, Marta Gagliardi, Kevin Valentino, Lucia Grazia Tricarico, Mariateresa De Sario, Alessandra Pisani, Maria Carla Finocchiaro, Laura Portale, Marco Greco, Emiliano Talanti, Anna Madera, Paola Stillo, Nicolò Chiti, Silvia Bloise, Silvia Sordelli, Mariangela Labruzzo, Massimo Lo Verde, Domenico Cipolla, Carlotta Farneti, Francesco Oppido, Giulia Sansovini, Giada Sartor, Marta Magnolato, Michele Maiola, Michela Pandullo, Sara Rivellini, and Giuseppina De Rosa

Subjects
Pediatrics, RJ1-570
Published
2024
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5. Implementation of the WHO standards to assess quality of care for children with acute pain in EDs: findings of a multicentre study (CHOICE) in Italy

Author

Egidio Barbi, Silvia Bressan, Stefano Masi, Marzia Lazzerini, Paola Cogo, Vanna Graziani, Federico Marchetti, Giorgio Cozzi, Ilaria Mariani, Valentina Baltag, Ilaria Liguoro, Francesca Tirelli, Chiara Stefani, Sarah Contorno, Stefano Martelossi, Alessandro Amaddeo, Alessia Marcellino, Riccardo Lubrano, Enrico Felici, Annunziata Lucarelli, Gian Luca Trobia, Elia Balestra, Benmario Castaldo, Alice Del Colle, Chiara Pilotto, Paola Moras, Marcella Massarotto, Paola Crotti, Benedetta Ferro, Riccardo Pavanello, Silvia Fasoli, Chiara Grisaffi, Idanna Sforzi, Rosa Santangelo, Andrea Iuorio, Sara Dal Bo, Vanessa Martucci, Mariateresa Sanseviero, Roberta Parrino, Giuseppina de Rosa, Vita Antonella Di Stefano, Francesca Patané, Marta Minute, Fabio Cardinale, Alessandra Iacono, Angela Troisi, Marta Arrabito, Paolo Dalena, Massimo Dagnelut, Maristella Toniutti, Silvia Galiazzo, Maria Luisa Casciana, Marta Gagliardi, Kevin Valentino, Lucia Grazia Tricarico, Mariateresa De Sario, Alessandra Pisani, Maria Carla Finocchiaro, Laura Portale, Marco Greco, Emiliano Talanti, Anna Madera, Paola Stillo, Nicolò Chiti, Silvia Bloise, Silvia Sordelli, Mariangela Labruzzo, Massimo Lo Verde, Domenico Cipolla, Carlotta Farneti, Francesco Oppido, Giulia Sansovini, Giada Sartor, Marta Magnolato, Michele Maiola, Michela Pandullo, and Sara Rivellini

Subjects
Pediatrics, RJ1-570
Published
2024
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6. Implementation of the WHO Standards to assess the quality of paediatric care using health workers as source of data: findings of a multicentre study (CHOICE) in Italy

Author

Egidio Barbi, Silvia Bressan, Stefano Masi, Marzia Lazzerini, Paola Cogo, Vanna Graziani, Federico Marchetti, Ilaria Mariani, Valentina Baltag, Ilaria Liguoro, Francesca Tirelli, Chiara Stefani, Sarah Contorno, Stefano Martelossi, Alessia Marcellino, Riccardo Lubrano, Enrico Felici, Annunziata Lucarelli, Gian Luca Trobia, Elia Balestra, Benmario Castaldo, Alice Del Colle, Chiara Pilotto, Paola Moras, Marcella Massarotto, Paola Crotti, Benedetta Ferro, Riccardo Pavanello, Silvia Fasoli, Chiara Grisaffi, Idanna Sforzi, Rosa Santangelo, Andrea Iuorio, Vanessa Martucci, Mariateresa Sanseviero, Roberta Parrino, Giuseppina de Rosa, Vita Antonella Di Stefano, Francesca Patané, Marta Minute, Fabio Cardinale, Alessandra Iacono, Marta Arrabito, Paolo Dalena, Massimo Dagnelut, Maristella Toniutti, Silvia Galiazzo, Maria Luisa Casciana, Marta Gagliardi, Kevin Valentino, Lucia Grazia Tricarico, Mariateresa De Sario, Alessandra Pisani, Maria Carla Finocchiaro, Laura Portale, Marco Greco, Emiliano Talanti, Anna Madera, Paola Stillo, Nicolò Chiti, Silvia Bloise, Silvia Sordelli, Mariangela Labruzzo, Massimo Lo Verde, Domenico Cipolla, Carlotta Farneti, Francesco Oppido, Giulia Sansovini, Giada Sartor, Marta Magnolato, Michele Maiola, Michela Pandullo, Sara Rivellini, Sara Dal Bo, Giuseppina De Rosa, Dal Bo Sara, Troisi Angela, Cozzi Giorgio, and Amaddeo Alessandro

Subjects
Pediatrics, RJ1-570
Published
2024
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7. Increased bronchiolitis burden and severity after the pandemic: a national multicentric study

Author

Sergio Ghirardo, Nicola Ullmann, Alessandro Zago, Michele Ghezzi, Marta Minute, Barbara Madini, Enza D’Auria, Cecilia Basile, Francesca Castelletti, Federica Chironi, Agata Capodiferro, Beatrice Andrenacci, Francesco Maria Risso, Salvatore Aversa, Laura Dotta, Antonella Coretti, Anna Chiara Vittucci, Raffaele Badolato, Alessandro Amaddeo, Egidio Barbi, and Renato Cutrera

Subjects
Bronchiolitis, Post-phandemic viral epidemiology, Bronchiolitis severity, Coinfections, COVID-19 and bronchiolitis, Pediatrics, RJ1-570
Abstract

Abstract Background The coronavirus 2019 (COVID-19) related containment measures led to the disruption of all virus distribution. Bronchiolitis-related hospitalizations shrank during 2020–2021, rebounding to pre-pandemic numbers the following year. This study aims to describe the trend in bronchiolitis-related hospitalization this year, focusing on severity and viral epidemiology. Methods We conducted a retrospective investigation collecting clinical records data from all infants hospitalized for bronchiolitis during winter (1st September-31th March) from September 2018 to March 2023 in six Italian hospitals. No trial registration was necessary according to authorization no.9/2014 of the Italian law. Results Nine hundred fifty-three infants were hospitalized for bronchiolitis this last winter, 563 in 2021–2022, 34 in 2020–2021, 395 in 2019–2020 and 483 in 2018–2019. The mean length of stay was significantly longer this year compared to all previous years (mean 7.2 ± 6 days in 2022–2023), compared to 5.7 ± 4 in 2021–2022, 5.3 ± 4 in 2020–2021, 6.4 ± 5 in 2019–2020 and 5.5 ± 4 in 2018–2019 (p

Published
2024
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8. Impact of near infrared light in pediatric blood drawing Centre on rate of first attempt success and time of procedure

Author

Ester Conversano, Giorgio Cozzi, Matteo Pavan, Marta Minute, Elena Gortan, Marcella Montico, Liza Vecchi Brumatti, Luca Ronfani, and Egidio Barbi

Subjects
Phlebotomy, Venipuncture, Blood sample, Near-infrared light, Pediatric, Pediatrics, RJ1-570
Abstract

Abstract Background Peripheral blood access and venipuncture are a stressful and painful experience in pediatric patients; moreover, it is estimated that more than one attempt is required to achieve the procedure in about one third of children. For this reason, we investigated if Near-infrared light technology routinely used, could give an advantage to venipuncture in a pediatric blood center setting. Methods We conducted an open, pseudo-randomized controlled trial with two parallel arms, in the blood-drawing center, with enrolment of 115 patients between 0 and 18 years, in 14 consecutive working days. Fifty-three subjects were enrolled in group 1 (VeinViewer®) and 62 in group 2 (control group). We divided patients into three subgroups considering their age ( 10 years). The primary study outcome was to assess if the use of VeinViewer® was associated with a reduction of time to perform blood sampling. The secondary outcome was to analyze VienViewer®‘s impact on first attempt success rate in blood sampling. Results No difference was found regarding the duration of blood sampling between the two groups, even after stratifying the patients into the three age subgroups. There was no difference between the two groups in the success at the first attempt in blood sampling. Conclusions Routine use of VeinViewer® is not useful to reduce time of the procedure during venipuncture. Trial registration The study was registered with ClinicalTrials.gov, with number NCT03277092, on September 8, 2017.

Published
2018
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9. Proceedings of the 23rd Paediatric Rheumatology European Society Congress: part two

Author

Olga Lomakina, Ekaterina Alekseeva, Sania Valieva, Tatiana Bzarova, Irina Nikishina, Elena Zholobova, Svetlana Rodionovskaya, Maria Kaleda, Yasuo Nakagishi, Masaki Shimizu, Mao Mizuta, Akihiro Yachie, Yuko Sugita, Nami Okamoto, Kousuke Shabana, Takuji Murata, Hiroshi Tamai, Eve M. Smith, Peng Yin, Andrea L. Jorgensen, Michael W. Beresford, on behalf of On behalf of the UK JSLE Cohort Study, Antonio Eleuteri, Beatrice Goilav, Laura Lewandowski, Angel Phuti, Dawn Wahezi, Tamar Rubinstein, Caroline Jones, Paul Newland, Stephen Marks, Rachel Corkhill, Diana Ekdawy, Clarissa Pilkington, Kjell Tullus, Chaim Putterman, Chris Scott, Antony C. Fisher, Andrea Jorgensen, Ezgi Deniz Batu, Can Kosukcu, Ekim Taskiran, Sema Akman, Kubra Ozturk, Betul Sozeri, Erbil Unsal, Zelal Ekinci, Yelda Bilginer, Mehmet Alikasifoglu, Seza Ozen, Hanna Lythgoe, Hermine I. Brunner, Gaurav Gulati, Jordan T. Jones, Mekibib Altaye, Jamie Eaton, Mark Difrancesco, Joo Guan Yeo, Jingyao Leong, Loshinidevi D/O Thana Bathi, Thaschawee Arkachaisri, Salvatore Albani, Nagla Abdelrahman, Michael W Beresford, Valentina Leone, UK JSLE study group supported by the National Institute of Health Research Clinical Research Network, Noortje Groot, D. Shaikhani, I. E. M. Bultink, M. Bijl, R. J. E. M. Dolhain, Y. K. O. Teng, E. Zirkzee, K. de Leeuw, R. Fritsch-Stork, S. S. M. Kamphuis, Rachael D. Wright, Reem Abdawani, Laila Al Shaqshi, Ibrahim Al Zakwani, Natali W. Gormezano, David Kern, Oriany L. Pereira, Gladys C. C. Esteves, Adriana M. Sallum, Nadia E. Aikawa, Rosa M. Pereira, Clovis A. Silva, Eloisa Bonfa, Jessica Beckmann, Nora Bartholomä, Nils Venhoff, Philipp Henneke, Ulrich Salzer, Ales Janda, Alina Lucica Boteanu, Sandra Garrote Corral, Alberto Sifuentes Giraldo, Mariluz Gámir Gámir, Antonio Zea Mendoza, Amra Adrovic, Reyhan Dedeoglu, Sezgin Sahin, Kenan Barut, Aida Koka, Funda Oztunc, Ozgur Kasapcopur, Ana Luisa Rodriguez-Lozano, Francisco Rivas-Larrauri, Silvestre García de la Puente, Andressa G. F. Alves, Maria F. D. A. Giacomin, Juliana Farhat, Alfésio L. F. Braga, Adriana M. E. Sallum, Lúcia M. D. A. Campos, Luiz A. A. Pereira, Ana J. D. F. C. Lichtenfels, Clóvis A. Silva, Sylvia C. L. Farhat, Banu Acar, Z. Birsin Ozcakar, Nilgün Çakar, Nermin Uncu, Gökçe Gür, Semanur Özdel, Fatoş Yalçınkaya, Christiaan Scott, Nicky Brice, Peter Nourse, Christine Arango, Angela C. Mosquera, Clara Malagon, Ana P. Sakamoto, Marco F. C. D. Silva, Ananadreia S. Lopes, Gleice C. S. Russo, Adriana E. M. Sallum, Katia Kozu, Eloisa Bonfá, Claudia Saad-Magalhães, Rosa M. R. Pereira, Claudio A. Len, Maria T. Terreri, Deepti Suri, Siyaram Didel, Amit Rawat, Surjit Singh, Despoina Maritsi, MArgarita Onoufriou, Olga Vougiouka, Maria Tsolia, Edi Paleka Bosak, Mandica Vidović, Mirta Lamot, Lovro Lamot, Miroslav Harjaček, Erika Van Nieuwenhove, Adrian Liston, Carine Wouters, Fatemeh Tahghighi, Vahid Ziaee, Seid-Reza Raeeskarami, Francisca Aguiar, Sandra Pereira, Mariana Rodrigues, Cláudia Moura, Gustavo Rocha, Hercília Guimarães, Iva Brito, Rita Fonseca, Gerd Horneff, Ariane Klein, Kirsten Minden, Hans-Iko Huppertz, Frank Weller-Heinemann, Jasmin Kuemmerle-Deschner, J-Peter Haas, Anton Hospach, BIKER collaborative group, Ricardo Menendez-Castro, Boris Huegle, Johannes-Peter Haas, Joost Swart, Gabriella Giancane, Francesca Bovis, Elio Castagnola, Andreas Groll, Daniel J. Lovell, Tom Wolfs, Michael Hofer, Violeta Panaviene, Susan Nielsen, Jordi Anton, Florence Uettwiller, Valda Stanevicha, Maria Trachana, Denise Pires Marafon, Constantin Ailioaie, Elena Tsitsami, Sylvia Kamphuis, Troels Herlin, Pavla Doležalová, Gordana Susic, Berit Flatø, Flavio Sztajnbok, Angela Pistorio, Alberto Martini, Nico Wulffraat, Nicolino Ruperto, Marco Gattorno, Antonio Brucato, Martina Finetti, George Lazaros, Silvia Maestroni, Mara Carraro, Davide Cumetti, Alessandra Carobbio, Monia Lorini, Alessandro Rimini, Renzo Marcolongo, Anna Valenti, Gian Luca Erre, Riccardo Belli, Fiorenzo Gaita, Maria Pia Sormani, Massimo Imazio, Mario Abinun, Nicola Smith, Tim Rapley, Flora McErlane, Lianne Kearsley-Fleet, Kimme L. Hyrich, Helen Foster, Nikolay Tzaribachev, Andrew Zeft, Rolando Cimaz, John Bohnsack, Thomas Griffin, Ruy Carrasco, Jason Dare, Ivan Foeldvari, Richard Vehe, Teresa Simon, Hermine Brunner, S. Verazza, S. Davì, A. Consolaro, A. Insalaco, V. Gerloni, R. Cimaz, F. Zulian, S. Pastore, F. Corona, G. Conti, P. Barone, M. Cattalini, E. Cortis, L. Breda, A. N. Olivieri, A. Civino, R. Podda, D. Rigante, F. La Torre, G. D’Angelo, M. Jorini, R. Gallizzi, M. C. Maggio, R. Consolini, A. De Fanti, M. G. Alpigiani, A. Martini, A. Ravelli, on behalf of Italian Pediatric Rheumatology Study Group, Aysenur Pac Kısaarslan, Zubeyde Gunduz, Ruhan Dusunsel, Ismail Dursun, Hakan Poyrazoglu, Ekaterina Kuchinskaya, Farida Abduragimova, Mikhail Kostik, Erik Sundberg, Soley Omarsdottir, Lena Klevenvall, Helena Erlandsson-Harris, Gokalp Basbozkurt, Ozge Erdemli, Dogan Simsek, Fatih Yazici, Yildirim Karsioglu, Aysen Tezcaner, Dilek Keskin, Huseyin Ozkan, Cengizhan Acikel, Erkan Demirkaya, Ilonka Orbán, Krisztina Sevcic, Valentin Brodszky, Emese Kiss, Ismaiel A. Tekko, Madeleine Rooney, James McElnay, Cliff Taggart, Helen McCarthy, Ryan F. Donnelly, Drug Delivery Group, Mary Slatter, Zohreh Nademi, Mark Friswell, Sharmila Jandial, Terence Flood, Sophie Hambleton, Andrew Gennery, Andrew Cant, Phoi-Ngoc Duong, Isabelle Koné-Paut, Giovanni Filocamo, María Luz Gamir, Helga Sanner, Laura Carenini, Mesut Topdemir, Yildirim Karslioglu, Faysal Gok, Nadezhda Tsurikova, Elena Ligostaeva, Navdha R. Ramchurn, O. Kostareva, I. Nikishina, S. Arsenyeva, S. Rodionovskaya, M. Kaleda, D. Alexeev, Ismail Dursun Dursun, Sara Murias, Estefania Barral, Rosa Alcobendas, Eugenia Enriquez, Agustin Remesal, Jaime de Inocencio, Tania M. Castro, Simone A. Lotufo, Tatjana Freye, Raffaella Carlomagno, Thomas Zumbrunn, Jan Bonhoeffer, Elvira Cannizzaro Schneider, Daniela Kaiser, Michaël Hofer, Véronique Hentgen, Andreas Woerner, Juvenile Inflammatory Rheumatism (JIR) Cohort, Tobias Schwarz, Jens Klotsche, Martina Niewerth, Gerd Ganser, ICON study group, Jerold Jeyaratnam, Nienke ter Haar, Donato Rigante, Fatma Dedeoglu, Ezgi Baris, Sebastiaan Vastert, Joost Frenkel, Jonathan S. Hausmann, Kathleen G. Lomax, Ari Shapiro, Karen L. Durrant, P. A. Brogan, M. Hofer, J. B. Kuemmerle-Deschner, B. Lauwerys, A. Speziale, K. Leon, X. Wei, R. M. Laxer, Sara Signa, Marta Rusmini, Elena Campione, Sabrina Chiesa, Alice Grossi, Alessia Omenetti, Roberta Caorsi, Gianmaria Viglizzo, Isabella Ceccherini, Silvia Federici, Helen Lachmann, Nicola Ruperto, on behalf of PRINTO and Eurofever Registry, Federica Vanoni, on behalf of PRINTO and Eurofever Project, Sonia Melo Gomes, Ebun Omoyinmi, Juan I. Arostegui, Eva Gonzalez-Roca, Despina Eleftheriou, Nigel Klein, Paul Brogan, Stefano Volpi, Elettra Santori, Paolo Picco, Claudia Pastorino, Gillian Rice, Alessandra Tesser, Yanick Crow, Fabio Candotti, Ada B. Sinoplu, Gozde Yucel, Gizem Pamuk, Laura O. Damian, Cecilia Lazea, Mihaela Sparchez, Paulina Vele, Laura Muntean, Adriana Albu, Simona Rednic, Calin Lazar, Leonardo O. Mendonça, Alessandra Pontillo, Jorge Kalil, Fabio M. Castro, Myrthes T. Barros, Manuela Pardeo, Virginia Messia, Fabrizio De Benedetti, Antonella Insalaco, Giorgia Malighetti, Chiara Gorio, Francesca Ricci, Ilaria Parissenti, Paola Montesano, Barbara Bonafini, Veronica Medeghini, Marco Cattalini, Lucio Giordano, Giulia Zani, Rosalba Ferraro, Donatella Vairo, Silvia Giliani, Maria Cristina Maggio, Girolamo Luppino, Giovanni Corsello, Maria Isabel Gonzalez Fernandez, Berta Lopez Montesinos, Adriana Rodriguez Vidal, Juan I. Arostegui Gorospe, Inmaculada Calvo Penades, Nadia K. Rafiq, Karen Wynne, Khalid Hussain, Paul A. Brogan, Elizabeth Ang, Nicholas Ng, Ayla Kacar, Ozge Altug Gucenmez, Balahan Makay, Sevket Erbil Unsal, Yasin Sahin, Tufan Kutlu, Fugen Cullu-Cokugras, Hasret Ayyildiz-Civan, Tulay Erkan, Sana Al Zuhbi, Eiman Abdalla, Ricardo A. Russo, María M. Katsicas, Francesca Minoia, Angelo Ravelli, Sagar Bhattad, Anju Gupta, Vignesh Pandiarajan, Ritambhra Nada, Kaara Tiewsoh, Philip Hawkins, Dorota Rowczenio, Sarka Fingerhutova, Jana Franova, Leona Prochazkova, Eva Hlavackova, Pavla Dolezalova, Havva Evrengül, Selçuk Yüksel, Mustafa Doğan, Dolunay Gürses, Harun Evrengül, Silvia De Pauli, Serena Pastore, Anna Monica Bianco, Giovanni Maria Severini, Andrea Taddio, Alberto Tommasini, Svetlana O. Salugina, Evgeny Fedorov, Elena Kamenets, Ekaterina Zaharova, Tatiana Sleptsova, Ekaterina Alexeeva, Kirill Savostyanov, Alexander Pushkov, Tatyana Bzarova, Saniya Valieva, Rina Denisova, Kseniya Isayeva, Evgeniya Chistyakova, Margarita Soloshenko, Elena Kaschenko, Utako Kaneko, Chihaya Imai, Akihiko Saitoh, Vitor A. Teixeira, Filipa O. Ramos, Manuela Costa, Yonatan Butbul Aviel, Shafe Fahoum, Riva Brik, Zeynep Birsin Özçakar, Banu Acar Celikel, Fatos Yalcinkaya, Benedetta Schiappapietra, Sergio Davi’, Federica Mongini, Luisa Giannone, Cecilia Bava, Maria Giannina Alpigiani, Alessandro Consolaro, Dragana S. Lazarevic, Jelena Vojinovic, Jelena Basic, Valentina Muratore, Valentina Marzetti, Neus Quilis, Belen Serrano Benavente, Alessandra Alongi, Adele Civino, Lorenzo Quartulli, Giedre Januskeviciute, Pieter van Dijkhuizen, N. Groot, W. van Dijk, A. Kardolus, Raul Gutiérrez Suárez, Ellen B. Nordal, Veronika G. Rypdal, Lillemor Berntson, Maria Ekelund, Kristiina Aalto, Suvi Peltoniemi, Marek Zak, Mia Glerup, Ellen D. Arnstad, Anders Fasth, Marite Rygg, the Nordic Study Group of Pediatric Rheumatology (NoSPeR), Ana Catarina Duarte, Sandra Sousa, Lídia Teixeira, Ana Cordeiro, Mª José Santos, Ana Filipa Mourão, Maria José Santos, Mónica Eusébio, Ana Lopes, Filipa Oliveira-Ramos, Manuel Salgado, Paula Estanqueiro, José Melo-Gomes, Fernando Martins, José Costa, Carolina Furtado, Ricardo Figueira, Jaime C. Branco, João E. Fonseca, Helena Canhão, Ana F. Mourão, Maria Jose Santos, Andrea Coda, Samuel Cassidy, Kerry West, Gordon Hendry, Debra Grech, Julie Jones, Fiona Hawke, Davinder Singh Grewal, Charlene Foley, Orla Killeen, Emma MacDermott, Douglas Veale, Ursula Fearon, Dilek Konukbay, Ela Tarakci, Nilay Arman, Sezgin Şahin, Jane Munro, Esi Morgan, Meredith Riebschleger, Jennifer Horonjeff, Vibeke Strand, Clifton Bingham, Ma. Theresa M. Collante, Margarita Ganeva, Stefan Stefanov, Albena Telcharova, Dimitrina Mihaylova, Radoslava Saraeva, Reni Tzveova, Radka Kaneva, Adelina Tsakova, Katya Temelkova, GRANT Medical University, Sofia 68/, Maria Mercedes C. Picarelli, Luiz C. Danzmann, Florencia Barbé-Tuana, Lucas K. Grun, Marcus H. Jones, Marijan Frković, Karla Ištuk, Ika Birkić, Saša Sršen, Marija Jelušić, Alan Easton, Rachael Quarmby, Raju Khubchandani, Mercedes Chan, Radoslav Srp, Katerina Kobrova, Dana Nemcova, Jozef Hoza, Michal Uher, Melania Saifridova, Lenka Linkova, Sirirat Charuvanij, Isree Leelayuwattanakul, Thita Pacharapakornpong, Sakda A.-O. Vallipakorn, Butsabong Lerkvaleekul, Soamarat Vilaiyuk, Stefano Lanni, Sergio Davì, Randy Q. Cron, Chiara Passarelli, Elisa Pisaneschi, Antonio Novelli, Claudia Bracaglia, Ivan Caiello, Kathy de Graaf, Florence Guilhot, Walter Ferlin, Grant Schulert, Alexi A. Grom, Robert Nelson, Cristina de Min, Dirk Holzinger, Christoph Kessel, Ndate Fall, Alexei Grom, Wilco de Jager, Raffaele Strippoli, Anna Horne, Stephan Ehl, Sandra Ammann, Kai Lehmberg, Karin Beutel, Dirk Foell, AnnaCarin Horne, Laura Pagani, Graciela Espada, Yi-jin Gao, Susan Shenoi, Sheila Weitzman, Giusi Prencipe, Antonia Pascarella, Walter G. Ferlin, Laurence Chatel, Philippe Jacqmin, Kathy De Graaf, Maria Ballabio, Zoë Johnson, Geneviève Lapeyre, Fabrizio de Benedetti, de Min Cristina, Hiroyuki Wakiguchi, Shunji Hasegawa, Reiji Hirano, Fumiko Okazaki, Tamaki Nakamura, Hidenobu Kaneyasu, Shouichi Ohga, Kazuko Yamazaki, Tomo Nozawa, Taichi Kanetaka, Shuichi Ito, Shumpei Yokota, Kirsty McLellan, Ishbel MacGregor, Neil Martin, Joyce Davidson, Sandra Hansmann, Andreas Eikelberg, Iris Haug, Sabrina Schuller, Susanne M. Benseler, Single Hub and Access point for paediatric Rheumatology in Europe (SHARE), Liliia S. Nazarova, Kseniia V. Danilko, Viktor A. Malievsky, Tatiana V. Viktorova, Angela Mauro, Angela Barnicoat, Jane Hurst, Nathalie Canham, Sandrine Lacassagne, Anastasia Wiener, Boris Hügle, Bernd Denecke, Ivan Costa-Filho, Johannes Peter Haas, Klaus Tenbrock, David Popp, Arjan Boltjes, Frank Rühle, Stefanie Herresthal, Femke van Wijk, Joachim Schultze, Monika Stoll, Luisa Klotz, Thomas Vogl, Johannes Roth, Estefania Quesada-Masachs, Daniel Álvarez de la Sierra, Marina Garcia Prat, Ana M. Marín Sánchez, Ricardo Pujol Borrell, Sara Marsal Barril, Mónica Martínez Gallo, Consuelo Modesto Caballero, Iryna Chyzheuskaya, Lyudmyla M. Byelyaeva, Rostislav M. Filonovich, Helena K. Khrustaleva, Larisa I. Zajtseva, Tamara M. Yuraga, Thomas Giner, Lukas Hackl, Julia Albrecht, Reinhard Würzner, Juergen Brunner, Marta Minute, Fulvio Parentin, Agostino Nocerino, Mette Nørgaard, Mikel Alberdi-Saugstrup, Marek S. Zak, Susan M. Nielsen, Ellen Nordal, Klaus G. Müller, Nordic Study Group of Pediatric Rheumatology (NoSPeR), Mojca Zajc Avramovič, Vita Dolžan, Nataša Toplak, Tadej Avčin, N. Ruperto, D. J. Lovell, C. Wallace, M. Toth, I. Foeldvari, J. Bohnsack, D. Milojevic, C. Rabinovich, D. Kingsbury, K. Marzan, P. Quartier, K. Minden, E. Chalom, G. Horneff, R. M. Kuester, J. Dare, M. Heinrich, H. Kupper, J. Kalabic, H. I. Brunner, on behalf of PRINTO and PRCSG, Ruben Burgos-Vargas, Tamas Constantin, Joke Dehoorne, Valda Stanevica, Katarzyna Kobusinska, Zbigniew Zuber, Richard Mouy, Ingrida Rumba-Rozenfelde, Chantal Job-Deslandre, Ronald Pederson, Jack Bukowski, Tina Hinnershitz, Bonnie Vlahos, Paula Keskitalo, Salla Kangas, Paula Vähäsalo, Raul A. Chavez Valencia, David Martino, Anne-Louise Ponsonby, Rachel Chiaroni-Clarke, Braydon Meyer, Roger C. Allen, Jonathan D. Akikusa, Jeffrey M. Craig, Richard Saffrey, Justine A. Ellis, Carol Wallace, Yosef Uziel, Gary Sterba, Rayfel Schneider, Ricardo Russo, Athimalaipet V. Ramanan, Jana Pachlopnik Schmid, Kim E Nichols, Paivi Miettunen, Toshiyuki Kitoh, Norman T. Ilowite, Jan-Inge Henter, Alexei A Grom, Edward M. Behrens, Tadej Avcin, Maurizio Aricò, Sriharsha Grevich, Peggy Lee, Sarah Ringold, Brian Leroux, Hannah Leahey, Megan Yuasa, Jessica Foster, Jeremy Sokolove, Lauren Lahey, William Robinson, Joshua Newson, Anne Stevens, Stephanie J. W. Shoop, Suzanne M. M. Verstappen, Wendy Thomson, Janet E. McDonagh, CAPS, Timothy Beukelman, Yuki Kimura, Marc Natter, Norm Ilowite, Kelly Mieszkalski, Grendel Burrell, Brian Best, Helen Bristow, Shannon Carr, Anne Dennos, Rachel Kaufmann, Laura Schanberg, for the CARRA Registry Investigators, Gabriele Simonini, Francesca Lancini, Margaux Gerbaux, Phu-Quoc Lê, Laurence Goffin, Valérie Badot, Céline La, Laure Caspers, François Willermain, Alina Ferster, Maria Ceci, Francesco Licciardi, Marco Turco, Francesca Santarelli, Davide Montin, Claudia Toppino, Clotilde Alizzi, Bruno Papia, Beatrice Vergara, Umberto Corpora, Luca Messina, Maria Tsinti, Vasiliko Dermentzoglou, Panagiotis Tziavas, Marija Perica, Lana Tambić Bukovac, Mustafa Çakan, Nuray Aktay Ayaz, Gonca Keskindemirci, Michael Lang, Catherine Laing, Susanne Benseler, Tommy Gerschman, Nadia Luca, Heinrike Schmeling, Anastasia Dropol, Jaymi Taiani, Nicole Johnson, Brian Rusted, Panagiota Nalbanti, Polyxeni Pratsidou, Grigoris Pardalos, Vasiliki Tzimouli, Anna Taparkou, Maria Stavrakidou, Fotios Papachristou, Florence Kanakoudi-Tsakalidou, Peter Bale, Emily Robinson, Jason Palman, Elizabeth Ralph, Kimberly Gilmour, Clare Heard, Lucy R. Wedderburn, Yara Barrense-Dias, Antonarakis Gregory, Dhouib Amira, Scolozzi Paolo, Hanquinet Sylviane, Hofer Michaël, Nataliya Panko, Salah Shokry, Liudmila Rakovska, Sally Pino, Adriana Diaz-Maldonado, Pilar Guarnizo, Sofia Torreggiani, Paolo Cressoni, Umberto Garagiola, Giancarla Di Landro, Giampietro Farronato, Fabrizia Corona, Samantha Bell, Parveen Bhatti, Lee Nelson, Beth A. Mueller, T. A. Simon, A. Baheti, N. Ray, Z. Guo, Anasuya Hazra, Thomas Stock, Ronnie Wang, Charles Mebus, Christine Alvey, Manisha Lamba, Sriram Krishnaswami, Umberto Conte, Min Wang, Daniel Kingsbury, Elena Koskova, Elzbieta Smolewska, Richard K. Vehe, Daniel Lovell, Tomohiro Kubota, Junko Yasumura, Toshitaka Kizawa, Masato Yashiro, Tsuyoshi Yamatou, Yuichi Yamasaki, Syuji Takei, Yoshifumi Kawano, Ulrika Järpemo Nykvist, Bo Magnusson, Rikard Wicksell, Karin Palmblad, Gunnar L. Olsson, Mohammadreza Modaressi, Mohammad-Hassan Moradinejad, Valentina Seraya, Alisa Vitebskaya, Veronica Moshe, Gil Amarilyo, Liora Harel, Phillip J Hashkes, Amir Mendelson, Noa Rabinowicz, Yonit Reis, Zane Dāvidsone, Arina Lazareva, Ruta Šantere, Dace Bērziņa, Valda Staņēviča, Giulia Camilla Varnier, Susan Maillard, Cristina Ferrari, Silvia Zaffarano, Juvenile Dermatomyositis Research Group and European Federation of Immunological Societies, Judith Wienke, Felicitas Bellutti Enders, Lucas L. van den Hoogen, Jorre S. Mertens, Timothy R. Radstake, Henny G. Hotten, Ruth Fritsch, Lucy Wedderburn, Kiran Nistala, Berent Prakken, Annet van Royen-Kerkhof, Mohammad Alhemairi, Mohammed Muzaffer, Pieter Van Dijkhuizen, Claire T. Deakin, Stefania Simou, Maria De Iorio, Qiong Wu, Tania Amin, Lee Dossetter, Juvenile Dermatomyositis Research Group (JDRG), Raquel Campanilho-Marques, Claire Deakin, Clarissa A. Pilkington, on behalf of Juvenile Dermatomyositis Research Group (JDRG), Silvia Rosina, Sirisucha Soponkanaporn, on behalf of the UK Juvenile Dermatomyositis Research Group (JDRG), Zehra S. Arıcı, Gökçen D. Tuğcu, Ezgi D. Batu, Hafize E. Sönmez, Deniz Doğru-Ersöz, Beril Talim, Nural Kiper, Seza Özen, Alexander Solyom, Ezgi Batu, John Mitchell, Ariana Kariminejad, Fatemeh Hadipour, Zahra Hadipour, Marta Torcoletti, Carlo Agostoni, Maja Di Rocco, Pranoot Tanpaiboon, Andrea Superti-Furga, Luisa Bonafé, Nur Arslan, Norberto Guelbert, Karoline Ehlert, Giedre Grigelioniene, Ratna Puri, Edward Schuchman, Pilar Gomez, Tatiana Gonzalez, Ricardo Yepez, Camilo Vargas, GRIP study group, Falcini Fernanda, Gemma Lepri, Alessandra Ferrari, Marco Matucci-Cerinic, Antonella Meini, Gian Marco Moneta, Emiliano Marasco, Rebecca Nicolai, Luisa Bracci-Laudiero, Olga Kopchak, Alexander Mushkin, Alexey Maletin, Catalina Mosquera, Rita A. Amorim, Juliana Molina, Gustavo Moreira, Flávia H. Santos, Melissa Fraga, Livia Keppeke, Vanessa M. Silva, Camila Hirotsu, Sergio Tufik, Maria Teresa Terreri, Vinícius L. Braga, Maria Beatriz Fonseca, Vania Schinzel, Maria Teresa R. Terreri, Liliana Jorge, Liana Guerra, Edson Amaro Junior, Maria Cristina Castiglione, Alessandra Tricarico, Emily Boulter, Andre Schultz, Kevin Murray, Fernanda Falcini, Stefano Stagi, Eleonora Bellucci, Ingrid H. R. Grein, Gecilmara Pileggi, Natália B. F. Pinto, Aline L. de Oliveira, Lyudmila Belyaeva, Rostislav Filonovich, Helena Khrustaleva, Larisa Zajtseva, Jaanika Ilisson, Chris Pruunsild, Olivier Gilliaux, Francis Corazza, Christophe Lelubre, on behalf of PANLAR Pediatric Rheumatology Study Group, Zoilo Morel, Claudia Saad-Magalhães C, Luis Lira, Mabel Ladino, Ruth Eraso, Ivonne Arroyo, Clovis Silva, Carlos Rose, and PANLAR Pediatric Rheumatology Study Group

Subjects
Pediatrics, RJ1-570, Diseases of the musculoskeletal system, RC925-935
Published
2017
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10. Children with cancer: a survey on the experience of Italian primary care pediatricians

Author

Marta Minute, Giorgio Cozzi, Chiara Plotti, Giuseppe Montanari, Paolo Pecile, Giulio Andrea Zanazzo, Alessandro Ventura, and Egidio Barbi

Subjects
Childhood cancer, Pediatric primary care, Pediatric oncology, Pediatrics, RJ1-570
Abstract

Abstract Background Cancer is the second cause of death in children and its diagnosis can be difficult, due to the presence of vague and non-specific symptoms. The primary care pediatrician is often involved in the diagnostic process, but no longer in child care once the treatment started. Care models involving both primary care pediatricians and oncologic referral centre highlighted a higher family satisfaction when they worked together. We conducted a survey on primary care pediatricians involved in childhood cancer in order to describe the actual situation. Methods We conducted a retrospective survey enrolling primary care pediatricians from a north-eastern area of Italy. They received a questionnaire that consisted in two parts: the first one aimed to assess the physician’s seniority and experience and the second one pertained to each case of cancer and explored the relationship between the pediatrician, the family and the referral centre, and pediatricians degree of satisfaction and emotional impact. Results We obtained data from 79 pediatricians who described 150 cancer cases. In 99 cases the primary care pediatrician had visited the child at the onset of symptoms and had referred him to the hospital. In 89 cases, he understood the severity of the disease. In 53.3% of cases the pediatrician was informed by the referral centre. The relationship between the pediatrician and child’s family improved in 38% of cases and this was related with their participation to the multidisciplinary meetings on child health. Conclusions Primary pediatricians’ sharing in the management of their patients with cancer was not satisfactory. Development of specific protocols targeted to an integrated care is needed to increase primary pediatricians’ involvement and families’ satisfactions.

Published
2017
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11. Impact and Sustainability of Antibiotic Stewardship in Pediatric Emergency Departments: Why Persistence Is the Key to Success

Author

Elisa Barbieri, Maia De Luca, Marta Minute, Carmen D’Amore, Marta Luisa Ciofi Degli Atti, Stefano Martelossi, Carlo Giaquinto, Liviana Da Dalt, Theoklis Zaoutis, and Daniele Dona

Subjects
antibiotic stewardship, pharyngitis, acute otitis media, clinical pathways, children, emergency departments, Therapeutics. Pharmacology, RM1-950
Abstract

Antibiotic stewardship programs proved to be effective in improving prescribing appropriateness. This multicenter quasi-experimental study, aimed to assesses the stewardship impact on antibiotics prescribing in different semesters from 2014 to 2019 in three pediatric emergency departments (Center A, B, and C) in Italy. All consecutive patients diagnosed with acute otitis media or pharyngitis were evaluated for inclusion. Two different stewardship were adopted: for Center A and B, clinical pathways were implemented and disseminated, and yearly lectures were held, for Center C, only pathways were implemented. Broad-spectrum prescription rates decreased significantly by 80% for pharyngitis and 29.5 to 55.2% for otitis after the implementation. In Center C, rates gradually increased from the year after the implementation. Amoxicillin dosage adjusted to pharyngitis recommendations in Center C (53.7 vs. 51.6 mg/kg/die; p = 0.011) and otitis recommendations in Center A increasing from 50.0 to 75.0 mg/kg/die (p < 0.001). Days of therapy in children < 24 months with otitis increased from 8.0 to 10.0 in Center A, while in older children decreased in Center A (8.0 vs. 7.0; p < 0.001) and Center B (10.0 vs. 8.0; p < 0.001). Clinical pathways combined with educational lectures is a feasible and sustainable program in reducing broad-spectrum antibiotic prescribing with stable rates over time.

Published
2020
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12. Prevalence of SARS-CoV-2 positivity in infants with bronchiolitis: a multicentre international study

Author

Giorgio, Cozzi, Luisa, Cortellazzo Wiel, Alessandro, Amaddeo, Antonio, Gatto, Manuela, Giangreco, Adi, Klein-Kremer, Samantha, Bosis, Davide, Silvagni, Carla, Debbia, Laura, Nanni, Sara, Chiappa, Marta, Minute, Ilaria, Corsini, Giuliana, Morabito, Anna Jolanda, Gortan, Marco, Colombo, Federico, Marchetti, Davide, Garelli, Arianna, Piffer, Fabio, Cardinale, Nitai, Levy, Antonietta, Curatola, Bojana, Gojsina, Suvradeep, Basu, Egidio, Barbi, Aleksandar, Sovtic, Jelena, Visekruna, Cozzi, Giorgio, Cortellazzo Wiel, Luisa, Amaddeo, Alessandro, Gatto, Antonio, Giangreco, Manuela, Klein-Kremer, Adi, Bosis, Samantha, Silvagni, Davide, Debbia, Carla, Nanni, Laura, Chiappa, Sara, Minute, Marta, Corsini, Ilaria, Morabito, Giuliana, Gortan, Anna Jolanda, Colombo, Marco, Marchetti, Federico, Garelli, Davide, Piffer, Arianna, Cardinale, Fabio, Levy, Nitai, Curatola, Antonietta, Gojsina, Bojana, Basu, Suvradeep, Barbi, Egidio, and Sovtic, Aleksandar

Subjects
Settore MED/38 - Pediatria Generale e Specialistica, COVID-19, epidemiology, intensive care units, paediatric emergency medicine, virology, Pediatrics, Perinatology and Child Health, intensive care unit
Abstract

BackgroundBronchiolitis is the leading acute respiratory tract infection in infants during the winter season. Since the beginning of the SARS-CoV-2 pandemic, a reduction in the number of bronchiolitis diagnoses has been registered.ObjectiveThe present study aimed to describe the incidence and clinical features of bronchiolitis during the 2020–2021 winter season in a large cohort of children in Europe and Israel, and to clarify the role of SARS-CoV-2.Setting, patients, interventionsWe conducted a multicentre observational cross-sectional study in 23 paediatric emergency departments in Europe and Israel. Clinical and demographic data about all the cases of infants diagnosed with bronchiolitis from 1 October 2020 to 30 April 2021 were collected. For each enrolled patient, diagnostic tests, treatments and outcomes were reported.Main outcome measuresThe main outcome was the prevalence of SARS-CoV-2-positive bronchiolitis.ResultsThree hundred and fourteen infants received a diagnosis of bronchiolitis during the study period. Among 535 infants who tested positive for SARS-CoV-2, 16 (3%) had bronchiolitis. Median age, male sex predominance, weight, history of prematurity and presence of comorbidities did not differ between the SARS-CoV-2-positive and SARS-CoV-2-negative groups. Rhinovirus was the most common involved pathogen, while respiratory syncytial virus (RSV) was detected in one case. SARS-CoV-2 bronchiolitis had a mild clinical course, with one patient receiving oxygen supplementation and none requiring paediatric or neonatal intensive care unit admission.ConclusionsDuring the SARS-CoV-2 pandemic, a marked decrease in the number of bronchiolitis diagnoses and the disappearance of the RSV winter epidemic were observed. SARS-CoV-2-related bronchiolitis was rare and mostly displayed a mild clinical course.

Published
2022

13. SARS-CoV-2-related bronchiolitis: a multicentre international study

Author

Giorgio Cozzi, Aleksandar Sovtic, Davide Garelli, Uros Krivec, Davide Silvagni, Ilaria Corsini, Marco Colombo, Manuela Giangreco, Antonietta Giannattasio, Gregorio Paolo Milani, Marta Minute, Federico Marchetti, Antonio Gatto, Carla Debbia, Anna Jolanda Gortan, Marta Massaro, Elpis Hatziagorou, Domenico Ravidà, Raz Diamand, Elizabeth Jones, Jelena Visekruna, Alessandro Zago, Egidio Barbi, Alessandro Amaddeo, and Luisa Cortellazzo Wiel

Subjects
Pediatrics, Perinatology and Child Health
Abstract

BackgroundBronchiolitis is the main acute lower respiratory tract infection in infants. Data regarding SARS-CoV-2-related bronchiolitis are limited.ObjectiveTo describe the main clinical characteristics of infants with SARS-CoV-2-related bronchiolitis in comparison with infants with bronchiolitis associated with other viruses.Setting, patients, interventionsA multicentre retrospective study was conducted in 22 paediatric emergency departments (PED) in Europe and Israel. Infants diagnosed with bronchiolitis, who had a test for SARS-CoV-2 and were kept in clinical observation in the PED or admitted to hospital from 1 May 2021 to 28 February 2022 were considered eligible for participation. Demographic and clinical data, diagnostic tests, treatments and outcomes were collected.Main outcome measuresThe main outcome was the need for respiratory support in infants testing positive for SARS-CoV-2 compared with infants testing negative.Results2004 infants with bronchiolitis were enrolled. Of these, 95 (4.7%) tested positive for SARS-CoV-2. Median age, gender, weight, history of prematurity and presence of comorbidities did not differ between the SARS-CoV-2-positive and SARS-CoV-2-negative infants. Human metapneumovirus and respiratory syncytial virus were the viruses most frequently detected in the group of infants negative for SARS-CoV-2.Infants testing positive for SARS-CoV-2 received oxygen supplementation less frequently compared with SARS-CoV-2-negative patients, 37 (39%) vs 1076 (56.4%), p=0.001, OR 0.49 (95% CI 0.32 to 0.75). They received less ventilatory support: 12 (12.6%) high flow nasal cannulae vs 468 (24.5%), p=0.01; 1 (1.0%) continuous positive airway pressure vs 125 (6.6%), p=0.03, OR 0.48 (95% CI 0.27 to 0.85).ConclusionsSARS-CoV-2 rarely causes bronchiolitis in infants. SARS-CoV-2-related bronchiolitis mostly has a mild clinical course.

Published
2023
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15. Distraction Using Buzzy or Handheld Computers During Venipuncture

Author

Giorgio Cozzi, Gabriella Bertossa, Veronica Dri, Franca Crevatin, Marta Minute, Patrizia Rizzitelli, Daniela Matassi, Egidio Barbi, Luca Ronfani, Cozzi, Giorgio, Crevatin, Franca, Dri, Veronica, Bertossa, Gabriella, Rizzitelli, Patrizia, Matassi, Daniela, Minute, Marta, Ronfani, Luca, and Barbi, Egidio

Subjects
medicine.medical_specialty, Analgesic, Pain, law.invention, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, Phlebotomy, children, Interquartile range, Rating scale, law, 030225 pediatrics, Distraction, medicine, Humans, Pain Management, 030212 general & internal medicine, Prospective Studies, Tertiary level, Child, Venipuncture, distraction, Buzzy, Mild pain, business.industry, General Medicine, Computers, Handheld, Pediatrics, Perinatology and Child Health, Emergency Medicine, Physical therapy, business
Abstract

Objectives Venipuncture is one of the most frequently performed painful procedures in children. The aim of this study was to investigate the effectiveness of 2 analgesic strategies for venipuncture in children in a specific setting like a blood-drawing center. Methods This was a prospective randomized controlled trial. It was conducted in the blood-drawing center of a tertiary level children's hospital in Italy, between November 2014 and February 2015. Eligible patients were children aged from 4 to 12 years referred to the blood-drawing center for venipuncture. Enrolled children were randomized to be distracted by Buzzy device or by playing with a handheld computer. The procedural pain was measured with the faces pain scale-revised by children aged from 4 to 7 years and with a numerical rating scale by children aged from 8 to 12 years. Results Two hundred children with a median age of 8 years were enrolled in the study. The self-reported procedural pain was not statistically different between the Buzzy group and the handheld computer group: median (interquartile range) = 3.0 (1.0-4.8) and 2.0 (1.0-4.8), respectively (P = 0.72). Children reported significant pain in 25% of cases with both distraction strategies. The procedural success rate at the first attempt was not significantly different in the 2 groups. Conclusions Analgesia provided by Buzzy or by a handheld computer was not significantly different in children undergoing venipuncture in a blood-drawing center, with the great proportion of them reporting no or mild pain during procedure.

Published
2021

16. Has COVID-19 Delayed the Diagnosis and Worsened the Presentation of Type 1 Diabetes in Children?

Author

Rabbone, Ivana, Schiaffini, Riccardo, Cherubini, Valentino, Maffeis, Claudio, Scaramuzza, Andrea, Diabetes Study Group of the Italian Society for Pediatric Endocrinology and Diabetes (Enrica Bertelli, Lucia, Ferlito, Adriana, Bobbio, Eleonardo, Schieven, Maurizio, Delvecchio, Giulio, Maltoni, Petra, Reinstadler, Barbara, Felappi, Francesco, Gallo, Carlo, Ripoli, Filomena, Pascarella, Filomena, A Stamati, Donatella Lo Presti, Felice, Citriniti, Stefano, Tumini, Maria, Zampolli, Rosaria De Marco, Claudio, Cavalli, Valeria De Donno, Sonia, Toni, Maria Susanna Coccioli, Giuseppe, D'Annunzio, Paola Sogno Valin, Dante, Cirillo, Silvia, Sordelli, Fortunato, Lombardo, Riccardo, Bonfanti, Chiara, Mameli, Predieri, Barbara, Adriana, Franzese, Dario, Iafusco, Silvia, Savastio, Gavina, Piredda, Francesca, Cardella, Valeria, Calcaterra, Emioli, Randazzo, Anna, Favia, Tosca, Suprani, Alessandra, Lasagni, Novella, Rapini, Irene, Rutigliano, Alberto, Gaiero, Luisa De Sanctis, Vittoria, Cauvin, Marta, Minute, Gianluca, Tornese, Francesca, Franco, Gianluca, Musolino, Marco, Marigliano, Silvia, Innaturato, Claudia, Arnaldi), Rabbone, Ivana, Schiaffini, Riccardo, Cherubini, Valentino, Maffeis, Claudio, Scaramuzza, Andrea, Tornese, Gianluca, Rabbone, I., Schiaffini, R., Cherubini, V., Maffeis, C., Scaramuzza, A., Italian Study Group of Diabetes of, Isped, and Iafusco, D

Subjects
Research design, Male, Pediatrics, Delayed Diagnosis, Cross-sectional study, Endocrinology, Diabetes and Metabolism, Clinical Laboratory Technique, 0302 clinical medicine, COVID-19 Testing, 030212 general & internal medicine, Viral, Child, Emergency Service, Delayed Diagnosi, COVID-19, diabetes mellitus type 1, Italy, Adolescent, Child, Preschool, Clinical Laboratory Techniques, Coronavirus Infections, Cross-Sectional Studies, Diabetes Mellitus, Type 1, Diabetic Ketoacidosis, Emergency Service, Hospital, Female, Humans, Infant, Pandemics, Pneumonia, Viral, SARS-CoV-2, Betacoronavirus, medicine.symptom, Human, Type 1, medicine.medical_specialty, Diabetic ketoacidosis, 030209 endocrinology & metabolism, Asymptomatic, Diabetic Ketoacidosi, 03 medical and health sciences, Hospital, Diabetes mellitus, Internal Medicine, medicine, Diabetes Mellitus, Preschool, Advanced and Specialized Nursing, Cross-Sectional Studie, Type 1 diabetes, Pandemic, business.industry, Coronavirus Infection, Emergency department, Pneumonia, medicine.disease, business
Abstract

OBJECTIVE To evaluate whether the diagnosis of pediatric type 1 diabetes or its acute complications changed during the early phase of the coronavirus disease 2019 (COVID-19) pandemic in Italy. RESEARCH DESIGN AND METHODS This was a cross-sectional, web-based survey of all Italian pediatric diabetes centers to collect diabetes, diabetic ketoacidosis (DKA), and COVID-19 data in patients presenting with new-onset or established type 1 diabetes between 20 February and 14 April in 2019 and 2020. RESULTS Fifty-three of 68 centers (77.9%) responded. There was a 23% reduction in new diabetes cases in 2020 compared with 2019. Among those newly diagnosed patients who presented in a state of DKA, the proportion with severe DKA was 44.3% in 2020 vs. 36.1% in 2019 (P = 0.03). There were no differences in acute complications. Eight patients with asymptomatic or mild COVID-19 had laboratory-confirmed severe acute respiratory syndrome coronavirus 2. CONCLUSIONS The COVID-19 pandemic might have altered diabetes presentation and DKA severity. Preparing for any “second wave” requires strategies to educate and reassure parents about timely emergency department attendance for non–COVID-19 symptoms.

Published
2020

18. Risk of hospitalisation after early-revisit in the emergency department

Author

Ilaria Proietti, Ilaria Fiorese, Lorenzo Monasta, Marta Minute, Giorgio Cozzi, Sergio Ghirardo, Egidio Barbi, and Lorenzo Calligaris

Subjects
Pediatrics, medicine.medical_specialty, education.field_of_study, business.industry, Population, Severe disease, 030208 emergency & critical care medicine, Retrospective cohort study, Emergency department, Triage, humanities, 03 medical and health sciences, 0302 clinical medicine, 030225 pediatrics, Pediatrics, Perinatology and Child Health, Emergency medicine, Cohort, medicine, business, Risk assessment, education, Paediatric emergency
Abstract

Aim Early-revisits are frequent in the paediatric emergency department (ED) setting, but few data are available about early-revisited patients. The aim of this study was to investigate the hospitalisation rate of a population of early-revisited patients and to detect if an early-revisited patient was at risk of a more severe disease. Methods Between June 2014 and January 2015, we conducted a retrospective cohort study, considering all patients presented to the ED of a tertiary level children's hospital in Italy. We selected all patients who were revisited within 72 h from the initial visit (study cohort), while all other patients accessed in the same period were considered the control cohort. The two cohorts were compared for age, gender, triage category, hospitalisation rate, diagnosis at admission and hospital length of stay. Results In the study period, we reviewed 10 750 visits, of which 430 (4%) were unplanned revisits for the same chief complaint within 72 h from the initial visit. Hospitalisation rate of early-revisited patients was significantly higher compared to control patients (8.4 vs. 2.9%). Hospitalisation rate increases in parallel with the number of revisits, but in many cases, it was not directly related to a worst triage category, neither to a longer hospital length of stay. Conclusion Early revisited patients in the ED had a significantly higher risk of hospitalisation, but this risk was only partially related to their clinical conditions.

Published
2017
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19. Afebrile seizures in infants: Never forget magnesium!

Author

Rita Giorgi, Giovanna Ventura, Paola Costa, Marta Minute, Flavio Faletra, and Giorgio Cozzi

Subjects
Pediatrics, medicine.medical_specialty, Metal metabolism, Magnesium, business.industry, Magnesium blood, Afebrile seizures, chemistry.chemical_element, 030209 endocrinology & metabolism, 03 medical and health sciences, 0302 clinical medicine, chemistry, Pediatrics, Perinatology and Child Health, Mutation (genetic algorithm), medicine, business, 030217 neurology & neurosurgery
Published
2018
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21. Sedation and analgesia in children with cerebral palsy: a narrative review

Author

Francesca Peri, Marta Minute, Alberto Di Mascio, Ingrid Rabach, Emanuela Aru, Egidio Barbi, Marianna Lucafò, Giorgio Cozzi, Rabach, I., Peri, F., Minute, M., Aru, E., Lucafo, M., Di Mascio, A., Cozzi, G., and Barbi, E.

Subjects
medicine.medical_specialty, Sedation, MEDLINE, Intellectual disability, Conscious Sedation, Pain, Cochrane Library, Cerebral palsy, 03 medical and health sciences, 0302 clinical medicine, 030225 pediatrics, Pediatric surgery, medicine, Humans, Pain Management, 030212 general & internal medicine, Child, Pain Measurement, business.industry, Cerebral Palsy, Procedural sedation, medicine.disease, Analgesia, Pediatrics, Perinatology and Child Health, Physical therapy, Anxiety, Narrative review, medicine.symptom, business
Abstract

Background: Patients with cognitive impairment due to cerebral palsy experience pain more often than healthy peers and frequently require diagnostic and therapeutic painful procedures. Analgesia and procedural sedation outside the operating room are often required, but they may not adequately be provided because of the inability to accurately recognize and classify the state of pain and for the perceived higher risk of complications. Data sources: We reviewed the available literature to highlight the specific risk factors and area of criticism, that should be further improved. We searched the Cochrane Library, Medline, Pubmed from 1987 to September 2018 using key words such as ‘cerebral palsy and children and pain’ or ‘sedation and cerebral palsy and children’. Results: While different pain scales are useful in recognizing pain expressions, anxiety scales are not available. Moreover, studies on non-pharmacological techniques do not always have comparable results. Several risk factors, from anatomic abnormalities to liver and kidney functioning, should be kept in mind before proceeding with sedation. Conclusions: Large trials are needed to assess the impact of non-pharmacological techniques and to evaluate which pain control strategy (pharmacological and non-pharmacological) should be used in different settings.

Published
2019

22. Impact of near infrared light in pediatric blood drawing Centre on rate of first attempt success and time of procedure

Author

Egidio Barbi, Luca Ronfani, Ester Conversano, Giorgio Cozzi, Matteo Pavan, Marta Minute, Marcella Montico, Liza Vecchi Brumatti, Elena Gortan, Conversano, Ester, Cozzi, Giorgio, Pavan, Matteo, Minute, Marta, Gortan, Elena, Montico, Marcella, Vecchi Brumatti, Liza, Ronfani, Luca, and Barbi, Egidio

Subjects
Male, medicine.medical_specialty, Time Factors, Time Factor, Near-infrared light, Adolescent, Infrared Rays, Pediatrics, law.invention, 03 medical and health sciences, 0302 clinical medicine, Secondary outcome, Randomized controlled trial, Phlebotomy, law, 030225 pediatrics, Medicine, Humans, Age Factor, Blood sample, Preschool, Child, Lighting, Pediatric, Near infrared light, Venipuncture, business.industry, Research, lcsh:RJ1-570, Age Factors, Infant, Newborn, Infant, lcsh:Pediatrics, 030208 emergency & critical care medicine, Infrared Ray, Perinatology and Child Health, Newborn, Blood center, Child, Preschool, Female, Pediatrics, Perinatology and Child Health, Physical therapy, business, Human, Blood sampling, Blood drawing
Abstract

Background Peripheral blood access and venipuncture are a stressful and painful experience in pediatric patients; moreover, it is estimated that more than one attempt is required to achieve the procedure in about one third of children. For this reason, we investigated if Near-infrared light technology routinely used, could give an advantage to venipuncture in a pediatric blood center setting. Methods We conducted an open, pseudo-randomized controlled trial with two parallel arms, in the blood-drawing center, with enrolment of 115 patients between 0 and 18 years, in 14 consecutive working days. Fifty-three subjects were enrolled in group 1 (VeinViewer®) and 62 in group 2 (control group). We divided patients into three subgroups considering their age ( 10 years). The primary study outcome was to assess if the use of VeinViewer® was associated with a reduction of time to perform blood sampling. The secondary outcome was to analyze VienViewer®‘s impact on first attempt success rate in blood sampling. Results No difference was found regarding the duration of blood sampling between the two groups, even after stratifying the patients into the three age subgroups. There was no difference between the two groups in the success at the first attempt in blood sampling. Conclusions Routine use of VeinViewer® is not useful to reduce time of the procedure during venipuncture. Trial registration The study was registered with ClinicalTrials.gov, with number NCT03277092, on September 8, 2017.

Published
2018

23. A quasi randomized-controlled trial to evaluate the effectiveness of clowntherapy on children’s anxiety and pain levels in emergency department

Author

Ingrid Rabach, Andrea Taddio, Rita Giorgi, Marta Minute, Egidio Barbi, Isabella Lonciari, Marcella Montico, Margherita Felluga, Felluga, Margherita, Rabach, Ingrid, Minute, Marta, Montico, Marcella, Giorgi, Rita, Lonciari, Isabella, Taddio, Andrea, and Barbi, Egidio

Subjects
Male, medicine.medical_specialty, media_common.quotation_subject, Pain, Anxiety, Pediatrics, law.invention, Laughter, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, Rating scale, Surveys and Questionnaires, 030225 pediatrics, Humans, Pain Management, Medicine, Clown therapy, Laughter Therapy, Prospective Studies, 030212 general & internal medicine, Child, Psychiatry, Pain Measurement, media_common, Emergency department, business.industry, Medical evaluation, Perinatology and Child Health, Procedural pain, Procedural Pain, Treatment Outcome, Child, Preschool, Pediatrics, Perinatology and Child Health, Female, medicine.symptom, Emergency Service, Hospital, business, Follow-Up Studies
Abstract

The aim of the study is to investigate if the presence of medical clowns during painful procedures in the emergency department (ED) affects children's anxiety and pain. Forty children (4-11 years) admitted to the ED with the need of painful procedures were prospectively enrolled. They were randomly assigned to the clown group, where children interacted with clowns or to the control group in which they were entertained by parents and ED nurses. The children's anxiety was assessed by the Children's Anxiety and Pain Scales; pain was evaluated with the Numerical Rating Scale and Wong-Backer Scale, according to the children's age. Staff and clown's opinions were evaluated by means of dedicated questionnaires. Children's anxiety levels in the clown group were significantly lower than those compared with the control group, while children's pain levels did not change between the two groups. Conclusion The presence of clowns in the ED before and during painful procedures was effective in reducing children's anxiety. What is known • Anxiety and fear caused by medical procedures exacerbate children's pain and may interfere with the procedure. • To reduce anxiety, fear, and pain and to facilitate patient's evaluation, different non-pharmacological approaches have been proposed and positive effects of laughter and humor have been reported. What is New: • The presence of clowns in the waiting room and in the ED during medical evaluation and painful procedures helps to reduce children's anxiety.

Published
2016
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24. Mental Health Problems in Children and Adolescents in the Emergency Department: 'The Times They Are A-Changin''

Author

Giovanna Ventura, Giorgio Cozzi, Marta Minute, and Egidio Barbi

Subjects
Mental Health Services, Adolescent, business.industry, Mental Disorders, MEDLINE, General Medicine, Emergency department, medicine.disease, Mental health, 03 medical and health sciences, 0302 clinical medicine, Patient Admission, 030225 pediatrics, Pediatrics, Perinatology and Child Health, Emergency Medicine, Medicine, Humans, 030212 general & internal medicine, Medical emergency, business, Child, Emergency Service, Hospital
Published
2017

25. Afebrile seizures in infants: Never forget magnesium!

Author

Marta, Minute, Giovanna, Ventura, Rita, Giorgi, Flavio, Faletra, Paola, Costa, and Giorgio, Cozzi

Subjects
Hypocalcemia, Seizures, Mutation, Humans, Infant, Female, Magnesium, Metal Metabolism, Inborn Errors
Published
2017

26. Somatic symptom disorder was common in children and adolescents attending an emergency department complaining of pain

Author

Mohamad Jaber, Egidio Barbi, Marcella Montico, Marta Minute, Giorgio Cozzi, Aldo Skabar, Alessandro Ventura, Angela Pirrone, Elena Neri, Cozzi, Giorgio, Minute, Marta, Skabar, Aldo, Pirrone, Angela, Jaber, Mohamad, Neri, Elena, Montico, Marcella, Ventura, Alessandro, and Barbi, Egidio

Subjects
Male, medicine.medical_specialty, Functional impairment, Adolescent, Pain, Paediatric emergency department, Somatic symptom disorder, Pediatrics, 03 medical and health sciences, 0302 clinical medicine, Somatic pain, Primary headache, 030225 pediatrics, Medicine, Humans, Medical history, Prospective Studies, Child, business.industry, Functional pain, Pediatrics, Perinatology and Child Health, General Medicine, Emergency department, Perinatology and Child Health, medicine.disease, Medically Unexplained Symptoms, Italy, Physical therapy, Observational study, Female, business, Emergency Service, Hospital, 030217 neurology & neurosurgery, Paediatric emergency
Abstract

Aim The aim of this study was to quantify the prevalence of somatic pain in a paediatric emergency department (ED). Methods We conducted a prospective observational study using patients admitted to the ED of an Italian children's hospital between December 2014 and February 2015. We enrolled children aged 7–17 who turned up at the ED complaining of pain. Patients and parents were asked to fill in a questionnaire to allow the analysis of the patients’ medical history and provide contact details for follow-up. We divided the enrolled patients into four groups: post-traumatic pain, organic pain, functional pain and somatic pain. The questionnaire was used to define pain characteristics and to generate an impairment score. Results Of the 713 patients who met inclusion criteria, 306 (42.9%) were enrolled in the study. Of these, 135 (44.0%) suffered from post-traumatic pain, 104 (34.0%) from organic pain, 41 (13.4%) from functional pain and 26 (8.6%) from somatic pain. Somatic pain patients had endured pain longer, had missed more school days and had suffered severe functional impairment. Conclusion This study highlighted that somatic pain was a significant contributor to paediatric emergency room visits and should be suspected and diagnosed in children reporting pain.

Published
2016

27. An adolescent with disabling abdominal pain

Author

Egidio Barbi, Marta Minute, Giorgio Cozzi, Minute, Marta, Cozzi, Giorgio, and Barbi, Egidio

Subjects
Abdominal pain, medicine.medical_specialty, Pediatrics, Adolescent, Nausea, media_common.quotation_subject, Vital signs, Stress, Severity of Illness Index, 03 medical and health sciences, 0302 clinical medicine, Weight loss, 030225 pediatrics, Severity of illness, Absenteeism, medicine, Humans, Girl, Medically Unexplained Symptom, Fatigue, media_common, Pain Measurement, business.industry, Cardiorespiratory fitness, General Medicine, Social Participation, Surgery, Abdominal Pain, Medically Unexplained Symptoms, Vomiting, Psychological, Female, Stress, Psychological, medicine.symptom, business, 030217 neurology & neurosurgery, Human
Abstract

A previously healthy teenager was taken to a paediatric emergency department with abdominal pain, nausea, and fatigue. The pain had started four months earlier and had increased in severity and frequency, occurring daily in the past month and resulting in her missing three weeks of school and preventing her from participating in other activities. Painkillers had not helped. The results of repeated diagnostic tests were all normal, including complete blood cell count; blood and faecal inflammatory markers; renal, hepatic, and pancreatic function; urine analysis; and serial abdominal ultrasound scans. Despite repeated medical evaluations, there was no defined diagnosis. The girl reported a dull discomfort in the periumbilical area. She had no fever, vomiting, stool alteration, weight loss, nocturnal pain, or sleep problems. Her parents were concerned that this was a serious illness, given the worsening of symptoms over the past month, the lack of response to drug treatment, and the absence of a clear diagnosis. On examination, the girl appeared well, although she rated her pain 8 out of 10. Vital signs were normal and cardiorespiratory and abdominal examinations were unremarkable.

Published
2016

28. Sirolimus Therapy in Congenital Hyperinsulinism: A Successful Experience Beyond Infancy

Author

Alessandro Ventura, Elena Faleschini, Giuseppa Patti, Gianluca Tornese, Chiara Zuiani, Marta Minute, Minute, Marta, Patti, Giuseppa, Tornese, Gianluca, Faleschini, Elena, Zuiani, Chiara, and Ventura, Alessandro

Subjects
Male, Pediatrics, medicine.medical_specialty, Octreotide, Child, Congenital Hyperinsulinism, Humans, Remission Induction, Sirolimus, ABCC8, Quality of life, medicine, Diazoxide, Adverse effect, biology, business.industry, hyperinsulinism sirolimus CHI, medicine.disease, Surgery, Partial Pancreatectomy, Pediatrics, Perinatology and Child Health, Congenital hyperinsulinism, biology.protein, business, medicine.drug
Abstract

Congenital hyperinsulinism (CHI) due to diffuse involvement of the pancreas is a challenging and severe illness in children. Its treatment is based on chronic therapy with diazoxide and/or octreotide, followed by partial pancreatectomy, which is often not resolutive. Sirolimus, a mammalian target of rapamycin inhibitor, was reported to be effective in treating CHI in infants. We report here the case of an 8-year-old boy affected by a severe form of CHI due to a biallelic heterozygous ABCC8 mutation who responded to sirolimus with a dramatic improvement in his glucose blood level regulation and quality of life, with no serious adverse events after 6 months of follow-up. To the best of our knowledge, this is the first report of a successful intervention in an older child. It provides a promising basis for further studies comparing sirolimus with other treatments, particularly in older children.

Published
2015

29. Galinstan Thermometer Is More Accurate Than Digital for the Measurement of Body Temperature in Children

Author

Marina Duranti, Silvana Schreiber, Luca Ronfani, Marta Minute, Gianluca Tornese, Egidio Barbi, Rita Giorgi, Schreiber, S, Minute, M, Tornese, Gianluca, Giorgi, R, Duranti, M, Ronfani, L, and Barbi, E.

Subjects
Male, Adolescent, Fever, Thermometers, chemistry.chemical_element, Sensitivity and Specificity, Body Temperature, Mercury thermometers, chemistry.chemical_compound, Predictive Value of Tests, Metals, Heavy, Alloys, Humans, Medicine, Prospective Studies, Child, Reference standards, Digital thermometers, business.industry, Infant, Mercury, General Medicine, Hospitals, Pediatric, Mercury (element), Galinstan, Italy, chemistry, Child, Preschool, Thermometer, Axilla, Pediatrics, Perinatology and Child Health, Emergency Medicine, Female, Emergency Service, Hospital, business, Nuclear medicine
Abstract

BACKGROUND: The mercury thermometer (MT) was considered the reference standard for the evaluation of body temperature; however, since April 2009, it has no longer been available in Italy. OBJECTIVE: This study aimed to evaluate the accuracy of digital thermometer (DT) and galinstan thermometer (GT) in comparison with the MT. METHODS: We prospectively recruited 284 children (age, 1 month to 17 years; mean, 8.5 years) seen in the emergency department of a tertiary pediatric hospital between November and December 2010. For each patient, body temperature was measured sequentially in the right axilla in a randomized fashion using DT, GT, and MT. Fever was defined as an axillary temperature of 37.5°C or greater. The temperature readings with DT and GT were compared statistically with those of MT (reference standard). RESULTS: No statistically significant difference in mean temperature was found between MT and GT in pairwise comparison (P = 0.06), whereas significant differences were found between MT and DT (P < 0.001) and between GT and DT (P < 0.001). Sensitivity and specificity of DT were 67.5% and 98.0%, respectively. When considering children with a temperature of 39°C or higher, the false-negative rate was 65.4% with DT and 30.8% with GT. CONCLUSIONS: Although both DT and GT had good specificity and positive predictive value compared with MT, GT had higher sensitivity and a lower rate of false-negative rates. Galinstan thermometer is more accurate in the measurement of body temperature compared with DT or MT.

Published
2013
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30. Experience from a single paediatric transplant centre with identification of some protective and risk factors concerning the development of hepatic veno-occlusive disease in children after allogeneic hematopoietic stem cell transplant

Author

Massimo Gregori, Antonio Pizzol, Valentina Kiren, Paolo Tamaro, Giovanna Ferrara, Marta Minute, Marcella Montico, Natalia Maximova, Maximova, N, Ferrara, G, Minute, M, Pizzol, A, Kiren, V, Montico, M, Gregori, M, and Tamaro, Paolo

Subjects
hepatic veno-occlusive disease, allogeneic hematopoietic stem cell transplant, Male, medicine.medical_specialty, Hepatic veno-occlusive disease, Adolescent, medicine.medical_treatment, Population, Hepatic Veno-Occlusive Disease, Hematopoietic stem cell transplantation, Disease, Defibrotide, Sepsis, Young Adult, Risk Factors, Internal medicine, medicine, Humans, Transplantation, Homologous, Mortality, education, Child, Retrospective Studies, education.field_of_study, business.industry, Mortality rate, Hematopoietic Stem Cell Transplantation, Infant, Newborn, Infant, Hematology, medicine.disease, Tacrolimus, Surgery, surgical procedures, operative, Child, Preschool, Female, business, medicine.drug
Abstract

Hepatic veno-occlusive disease (VOD) is a frequent and severe complication of hematopoietic stem cell transplantation (HSCT) affecting 9.6–17.3 % of cases. 200 HSCT, performed between January 1995 and March 2013 in our Paediatric HSCT Centre in Trieste, were retrospectively analysed to evaluate the frequency of VOD and to identify the associated risk factors. The frequency of VOD according to the Seattle criteria was 17 %, within the range reported in literature. The mortality rate was 37.5 % (75 out of 200 transplantations) in the general population and 73.5 % (25 out of 34) in VOD patients (p

Published
2014

31. Does EMLA cream application interfere with the success of venipuncture or venous cannulation? A prospective multicenter observational study

Author

Lorenza Matarazzo, Federico Poropat, E. Panontin, Silvana Schreiber, Luca Ronfani, Marta Minute, G. P. Chiaffoni, Claudio Germani, Egidio Barbi, Schreiber, S., Ronfani, L., Chiaffoni, G. P., Matarazzo, L., Minute, M., Panontin, Elisa, Poropat, F., Germani, C., and Barbi, E.

Subjects
Male, medicine.medical_specialty, Lidocaine, Venous cannulation, Pediatrics, Topical anesthetic, Prilocaine, Ointments, Phlebotomy, EMLA, Catheterization, Peripheral, medicine, Humans, Prospective Studies, Anesthetics, Local, Prospective cohort study, Child, Lidocaine, Prilocaine Drug Combination, Venipuncture, business.industry, Perinatology and Child Health, Surgery, Logistic Models, Vasoconstriction, Anesthesia, Child, Preschool, Pediatrics, Perinatology and Child Health, Observational study, Female, business, medicine.drug
Abstract

Venipuncture and intravenous cannulation are the most common painful procedures performed on children. The most widely used topical anesthetic is eutectic mixture of local anesthetics (EMLA). EMLA use is associated with a transient cutaneous vasoconstriction which can make it difficult to identify veins. We assessed with a prospective, multicenter, observational study whether EMLA interferes with venipuncture and intravenous cannulation. The primary study outcome was a success at first attempt in the course of venipuncture or venous cannulation. The study enrolled 388 children; 255 of them received EMLA and 133 did not. Eighty-six percent of procedures were successful at the first attempt in the EMLA group and 76.7 % in the no EMLA group. Conclusion: In this study, EMLA use did not interfere with the success of venipuncture or venous cannulation in children.

Published
2013

32. Under pressure

Author

Irene Berti, Angela De Cunto, Giorgio Longo, Marta Minute, De Cunto, A, Berti, I, Minute, M, and Longo, Giorgio

Subjects
Male, medicine.medical_specialty, integumentary system, Urticaria, business.industry, food and beverages, Delayed dermographism, medicine.disease, Dermatology, urticaria, immune system diseases, parasitic diseases, Pediatrics, Perinatology and Child Health, medicine, Pressure, Humans, Pressure urticaria, Physical urticaria, skin and connective tissue diseases, business, Child, Chronic urticaria
Abstract

Physical urticaria is a rare but challenging subset of chronic urticaria. Wheals of pressure urticaria are typically delayed in appearance. A pressure test can easily be done to confirm the diagnosis.

Published
2012

33. Videogame playing as distraction technique in course of venipuncture

Author

Laura Badina, Alessandro Ventura, Gabriele Cont, Luca Ronfani, Marta Minute, Marcella Montico, Egidio Barbi, Minute, M, Badina, Laura, Cont, G, Montico, M, Ronfani, L, Barbi, E, and Ventura, Alessandro

Subjects
Male, medicine.medical_specialty, Videogame, lcsh:Surgery, Pain, pain control, venipuncture, law.invention, Phlebotomy, children, Randomized controlled trial, Interquartile range, law, medicine, Humans, Prospective Studies, Videogame playing distraction, Anesthetics, Local, Child, Prospective cohort study, Lidocaine, Prilocaine Drug Combination, Venipuncture, business.industry, technique venipuncture, lcsh:RJ1-570, Lidocaine, lcsh:Pediatrics, lcsh:RD1-811, Prilocaine, Distress, Video Games, Child, Preschool, Anesthesia, Pediatrics, Perinatology and Child Health, FLACC scale, Physical therapy, Anxiety, Female, Surgery, Premedication, medicine.symptom, business
Abstract

Background: needle-related procedures (venipuncture, intravenous cannulation) are the most common source of pain and distress for children. reducing needle related pain and anxiety could be important in order to prevent further distress, especially for children needing multiple hospital admissions. the aim of the present open randomized controlled trial was to investigate the efficacy of adding an active distraction strategy (videogame) to eMlA premedication in needle-related pain in children. Methods: one-hundred and nine children (4 -10 years of age) were prospectively recruited to enter in the study. ninety-seven were randomized in two groups: CC group (conventional care: eMlA only) as control group and Ad group (active distraction: eMlA plus videogame) as intervention group. outcome measures were: selfreported pain by mean of FPS-r scale (main study outcome), observer-reported pain by FlACC scale, number of attempts for successful procedure. Results: in both groups FPS-r median rate was 0 (interquartile range: 0-2), with significant pain (FPS-r>4) reported by 9% of subjects. FlACC median rate was 1 in both groups (interquartile range 0-3 in CC group; 0-2 in Ad group). the percentage of children with major pain (FlACC>4) was 18% in CC group and 9% in Ad group (p=0.2). the median of necessary attempts to succeed in the procedures was 1 (interquartile range 1-2) in both groups.. Conclusion: Active distraction doesn’t improve eMlA analgesia for iv cannulation and venipuncture. even though, it resulted in an easily applicable strategy appreciated by children. this technique could be usefully investigated in other painful procedures.

Published
2012

34. Successful treatment of acne with isotretinoin in chronic granulomatous disease

Author

Floriana Zennaro, Egidio Barbi, Irene Berti, and Marta Minute

Subjects
medicine.medical_specialty, Pathology, business.industry, Dermatology, medicine.disease, Chronic granulomatous disease, Granulomatous disease, Immunopathology, medicine, business, Isotretinoin, Acne, medicine.drug
Abstract

Auteur(s) : Egidio BARBI1, Irene BERTI2, Marta MINUTE2 martaminute@gmail.com, Floriana ZENNARO3 1 Pediatria d’Urgenza, IRCCS Burlo Garofolo, University of Trieste, Italy 2 Clinica Pediatrica, IRCCS Burlo Garofolo, University of Trieste, Italy 3 Radiology Department, IRCCS Burlo Garofolo, University of Trieste, Italy Chronic granulomatous disease (CGD) is an immune deficiency caused by different mutations of the gene that encodes for the enzyme dinucleotide phosphate oxidase, which regulates free [...]

Published
2011
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