Search

Your search keyword '"Martínez-Valladares, Maria"' showing total 20 results
Start Over Author "Martínez-Valladares, Maria"
20 results on '"Martínez-Valladares, Maria"'

10. 100 Questions in Livestock Helminthology Research

Author

Morgan, Eric R., Aziz, Nor-Azlina A., Blanchard, Alexandra, Charlier, Johannes, Charvet, Claude, Claerebout, Edwin, Geldhof, Peter, Greer, Andrew W., Hertzberg, Hubertus, Hodgkinson, Jane, Höglund, Johan, Hoste, Hervé, Kaplan, Ray M., Martínez-Valladares, María, Mitchell, Siân, Ploeger, Harm W., Rinaldi, Laura, von Samson-Himmelstjerna, Georg, Sotiraki, Smaragda, Schnyder, Manuela, Skuce, Philip, Bartley, David, Kenyon, Fiona, Thamsborg, Stig M., Vineer, Hannah Rose, de Waal, Theo, Williams, Andrew R., van Wyk, Jan A., and Vercruysse, Jozef

Published
2019
Full Text
View/download PDF

11. Secretory IgA as Biomarker for Gastrointestinal Nematodes Natural Infection in Different Breed Sheep

Author

European Commission, Junta de Castilla y León, Giráldez, Francisco Javier [0000-0002-0680-1541], Balaña-Fouce, Rafael [0000-0003-0418-6116], Martínez Valladares, Maria [0000-0002-3723-1895], Castilla Gómez de Agüero, Verónica, Valderas García, Elora, González del Palacio, Laura, Giráldez, Francisco Javier, Balaña-Fouce, Rafael, Martínez Valladares, María, European Commission, Junta de Castilla y León, Giráldez, Francisco Javier [0000-0002-0680-1541], Balaña-Fouce, Rafael [0000-0003-0418-6116], Martínez Valladares, Maria [0000-0002-3723-1895], Castilla Gómez de Agüero, Verónica, Valderas García, Elora, González del Palacio, Laura, Giráldez, Francisco Javier, Balaña-Fouce, Rafael, and Martínez Valladares, María

Abstract

Specific IgA antibody has been shown to play an important role in resistance to gastrointestinal nematode (GIN) infections in sheep, particularly in Teladorsagia circumcincta parasitosis. In some breeds, negative associations have been shown between IgA levels and worm burden in experimentally infected sheep. In the present study, we have studied the relationship between IgA levels in naturally infected sheep (582 ewes in total; 193 younger than one year old and 389 older than one year old) and fecal egg count (FEC) in the Assaf, Castellana, and Churra breeds. ELISA assays were performed to measure IgA levels against the somatic antigen of T. circumcincta third larval stage (L3) and a 203-amino-acid fragment of the protein disulfide isomerase from the same GIN species. A multilevel random intercept model was developed to predict the infection risk according to age or breed. Spearman’s correlation rank was used for statistical analysis. The prediction model showed that breed was not an influential factor in this study, although the Assaf breed could be considered slightly more susceptible than the others. In addition, age affected the infection risk, with the young ewes more susceptible to infection than the adult groups, except for the Castellana breed, whose risk of infection was similar at all ages. The most significant positive association was found between FEC and IgA measured in the nasal secretions of young ewes using both antigens (Rho = 0.5; p = 0.00); the correlation of FEC with IgA in serum was moderately significant (Rho = 0.306; p = 0.00). Comparing both antigens, the protein disulfide isomerase antigen was less reactive than the somatic antigen from L3. In conclusion, under natural conditions, specific IgA against GIN was positively associated with FEC in sheep, with nasal secretions from young animals being the sample where this association is stronger, which, therefore, could be used as a marker of infection in further studies.

Published
2023

13. Molecular analysis of Strongyloides stercoralis beta-tubulin gene and the possible effects on albendazole efficacy

Author

Cambra Pelletjá, María, Grau-Pujol, B., Escola, V., Gandasegui, Javier, Jamine, J.C., Muchisse, O., Cossa, A., Messa Jr, A., Balaña-Fouce, R., Martínez Valladares, Maria, Cambra-Pelletjà, María, Martínez Valladares, María, Cambra-Pelletjà, María [0000-0002-8898-992X], and Martínez Valladares, María [0000-0002-3723-1895]

Abstract

Trabajo presentado al: 12th European Congress on Tropical Medicine and International Health (ECTMIH). Norway. 28 september-1 octubrer. Virtual meeting.

Published
2021

14. In vivo toxicity and efficacy of two diamine and one benzimidazole derivatives against the gastrointestinal nematode Haemonchus contortus

Author

Valderas García, E., Castilla Gómez de Agüero, V., Cambra Pelletjá, María, del Olmo, Esther, Balaña-Fouce, R., Martínez Valladares, Maria, Ministerio de Economía y Competitividad (España), Agencia Estatal de Investigación (España), European Commission, Junta de Castilla y León, Valderas García, Elora, Castilla Gómez de Agüero, Verónica, Cambra-Pelletjà, María, Martínez Valladares, María, Valderas García, Elora [0000-0002-9970-896X], Castilla Gómez de Agüero, Verónica [0000-0002-6797-0170], Cambra-Pelletjà, María [0000-0002-8898-992X], and Martínez Valladares, María [0000-0002-3723-1895]

Abstract

Trabajo presentado al: 28th International Conference of the World Association for the Advancement of Veterinary Parasitology (WAAVP). Dublín. Virtual meeting., MINECO (AEI, FEDER, UE): AGL2016-79813-C2-1R/2R and SAF2017-83575-R and Junta de Castilla y León (JCyL) cofinanced by FEDER, UE [LE020p17]. EVG is funded by JCyL and MMV by Ramón y Cajal Programme (RYC-2015-18368).

Published
2021

15. Characterization of a new albendazole resistant Fasciola hepatica isolate

Author

Martínez Valladares, Maria, Valderas García, E., Castilla Gómez de Agüero, V., González-Warleta, M., Ceballos, L., Lirón, J. P., Sanabria, R., Pruzzo, C., Alvarez, L. I., Martínez Valladares, María, Valderas García, Elora, Castilla Gómez de Agüero, Verónica, Martínez Valladares, María [0000-0002-3723-1895], Valderas García, Elora [0000-0002-9970-896X], and Castilla Gómez de Agüero, Verónica [0000-0002-6797-0170]

Abstract

Trabajo presentado al: 28th International Conference of the World Association for the Advancement of Veterinary Parasitology (WAAVP). Dublín. p. 86. 19-22 julio. Virtual meeting.

Published
2021

17. Quantitative trait loci for resistance to trichostrongylid infection in Spanish Churra sheep

Author

Primitivo Fermin San, Meana Aranzazu, Bayón Yolanda, de la Fuente Luis-Fernando, Martínez-Valladares Maria, Álvarez Lorena, Pérez Jorge, Gutiérrez-Gil Beatriz, Rojo-Vázquez Francisco-Antonio, and Arranz Juan-José

Subjects
Animal culture, SF1-1100, Genetics, QH426-470
Abstract

Abstract Background For ruminants reared on grazing systems, gastrointestinal nematode (GIN) parasite infections represent the class of diseases with the greatest impact on animal health and productivity. Among the many possible strategies for controlling GIN infection, the enhancement of host resistance through the selection of resistant animals has been suggested by many authors. Because of the difficulty of routinely collecting phenotypic indicators of parasite resistance, information derived from molecular markers may be used to improve the efficiency of classical genetic breeding. Methods A total of 181 microsatellite markers evenly distributed along the 26 sheep autosomes were used in a genome scan analysis performed in a commercial population of Spanish Churra sheep to detect chromosomal regions associated with parasite resistance. Following a daughter design, we analysed 322 ewes distributed in eight half-sib families. The phenotypes studied included two faecal egg counts (LFEC0 and LFEC1), anti-Teladorsagia circumcincta LIV IgA levels (IgA) and serum pepsinogen levels (Peps). Results The regression analysis revealed one QTL at the 5% genome-wise significance level on chromosome 6 for LFEC1 within the marker interval BM4621-CSN3. This QTL was found to be segregating in three out of the eight families analysed. Four other QTL were identified at the 5% chromosome-wise level on chromosomes 1, 10 and 14. Three of these QTL influenced faecal egg count, and the other one had an effect on IgA levels. Conclusion This study has successfully identified segregating QTL for parasite resistance traits in a commercial population. For some of the QTL detected, we have identified interesting coincidences with QTL previously reported in sheep, although most of those studies have been focused on young animals. Some of these coincidences might indicate that some common underlying loci affect parasite resistance traits in different sheep breeds. The identification of new QTL may suggest the existence of complex host-parasite relationships that have unique features depending on the host-parasite combination, perhaps due to the different mechanisms underlying resistance in adult sheep (hypersensitivity reactions) and lambs (immunity). The most significant QTL identified on chromosome 6 for LFEC1 may be the target for future fine-mapping research efforts.

Published
2009
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results