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4. Global DNA methylation and telomere length as markers of accelerated aging in people living with HIV and non-alcoholic fatty liver disease

Author

Moreno, Elena, Martínez-Sanz, Javier, Martín-Mateos, Rosa, Díaz-Álvarez, Jorge, Serrano-Villar, Sergio, Burgos-Santamaría, Diego, Luna, Laura, Vivancos, María Jesús, Moreno-Zamora, Ana, Pérez-Elías, María Jesús, Moreno, Santiago, Dronda, Fernando, Montes, María Luisa, and Sánchez-Conde, Matilde

Published
2023
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7. Expanding HIV clinical monitoring: the role of CD4, CD8, and CD4/CD8 ratio in predicting non-AIDS events

Author

Jarrín, Inma, Dalmau, David, Navarro, M. Luisa, González, M. Isabel, Garcia, Federico, Poveda, Eva, Iribarren, Jose Antonio, Gutiérrez, Félix, Rubio, Rafael, Vidal, Francesc, Berenguer, Juan, González, Juan, Muñoz-Fernández, M. Ángeles, Jarrín, Inmaculada, Moreno, Cristina, Rava, Marta, Izquierdo, Rebeca, Mauleón, Elba, Portilla, Joaquín, Portilla, Irene, Merino, Esperanza, García, Gema, Agea, Iván, Sánchez-Payá, José, Rodríguez, Juan Carlos, Giner, Livia, Reus, Sergio, Boix, Vicente, Torrus, Diego, Pérez, Verónica, Portilla, Julia, Gómez, Juan Luís, Hernández, Jehovana, Lirola, Ana López, García, Dácil, Díaz-Flores, Felicitas, Alonso, M. Mar, Pelazas, Ricardo, Alemán, M. Remedios, Asensi, Víctor, Rivas Carmenado, María Eugenia, Suarez-Zarracina, Tomás, Pulido, Federico, Bisbal, Otilia, Hernando, M. Asunción, Rial, David, de Lagarde, María, Arce, Octavio, Pinto, Adriana, Bermejo, Laura, Santacreu, Mireia, Navarro, Roser, Gonzalez, Candela, Aramburu, M. José, Camino, Xabier, Ángel von Wichmann, Miguel, Goenaga, Miguel Ángel, Bustinduy, M. Jesús, Azkune, Harkaitz, Ibarguren, Maialen, Kortajarena, Xabier, Álvarez-Rodriguez, Ignacio, Gil, Leire, Martínez, Lourdes, Robledano, Catalina, Masiá, Mar, Padilla, Sergio, Adsuar, Araceli, Pascual, Rafael, Fernández, Marta, Galiana, Antonio, García, José Alberto, Barber, Xavier, Agullo, Vanessa, Abellán, Javier Garcia, Pascual, Reyes, Telenti, Guillermo, Guillén, Lucia, Botella, Ángela, Muga, Roberto, Sanvisens, Arantza, Fuster, Daniel, Gutierrez, Isabel, López, Juan Carlos, Ramírez, Margarita, Padilla, Belén, Gijón, Paloma, Aldamiz-Echevarría, Teresa, Tejerina, Francisco, Diez, Cristina, Pérez, Leire, Fanciulli, Chiara, Corral, Saray, Martí, Anna, Peraire, Joaquín, Viladés, Consuelo, Vargas, Montserrat, Olona, Montserrat, Rull, Anna, Alba, Verónica, Yeregui, Elena, Masip, Jenifer, García-Pardo, Graciano, Bertomeu, Frederic Gómez, Espineira, Sonia, Montero, Marta, Cuéllar, Sandra, Blanes, Marino, Tasias, María, Calabuig, Eva, Salavert, Miguel, Fernández, Juan, Segarra, Inmaculada, González-García, Juan, Delgado, Ana, Arnalich, Francisco, Arribas, José Ramón, Bernardino, Jose Ignacio, Castro, Juan Miguel, Escosa, Luis, Herranz, Pedro, Hontañón, Victor, García-Bujalance, Silvia, García, Milagros, González-Baeza, Alicia, Martín-Carbonero, M. Luz, Mayoral, Mario, Mellado, M. Jose, Esteban, Rafael, Montejano, Rocío, Montes, M. Luisa, Moreno, Victoria, Pérez-Valero, Ignacio, Rodés, Berta, Rúa, Guadalupe, Sainz, Talía, Sendagorta, Elena, Valencia, Eulalia, Busca, Carmen, Cano, Joanna, Cardiñanos, Julen, de Miguel, Rosa, Blanco, Jose Ramón, Pérez-Martínez, Laura, Oteo, José Antonio, Ibarra, Valvanera, Metola, Luis, Sanz, Mercedes, Arazo, Piedad, Sampériz, Gloria, Martinez, Marina, Jaén, Angels, Sanmartí, Montse, Cairó, Mireia, Martinez-Lacasa, Javier, Velli, Pablo, Font, Roser, Xercavins, Mariona, Alonso, Noemí, Aiello, Francesco, Rivero, María, Piérola, Beatriz, Goikoetxea, Maider, Gracia, María, Ibero, Carlos, Moreno, Estela, Repáraz, Jesús, Navarro, Gemma, Garcia, Manel Cervantes, Isbert, Sonia Calzado, Vilasaro, Marta Navarro, Garcia, Belen Lopez, Santos, Ignacio de los, Santos, Alejandro de los, Sanz, Jesús, García-Fraile, Lucio, Martín, Enrique, Sánchez-Cerrillo, Ildefonso, Calvet, Marta, Barrios, Ana, Bautista, Azucena, Sáez, Carmen, Ciudad, Marianela, Gutiérrez, Ángela, Moreno, Santiago, Campo, Santos del, Casado, José Luis, Dronda, Fernando, Moreno, Ana, Pérez, M. Jesús, Serrano, Sergio, Vivancos, M<ce:sup loc='post">a</ce:sup> Jesús, Martínez-Sanz, Javier, Vallejo, Alejandro, Sanchez, Matilde, Pérez-Molina, Jose Antonio, Hermida, José Manuel, Bernal, Enrique, Alcaraz, Antonia, Bravo, Joaquín, Muñoz, Ángeles, Tomás, Cristina, Martínez, Mónica, Villalba, M. Carmen, García, Federico, Martínez, Clara, Hernández, José, Medina, Leopoldo Muñoz, Álvarez, Marta, Chueca, Natalia, Vinuesa, David, de Salazar, Adolfo, Fuentes, Ana, Guirao, Emilio, Viñuela, Laura, Ruiz-Sancho, Andrés, Anguita, Francisco, Del Romero, Jorge, Raposo, Montserrat, Rodríguez, Carmen, Puerta, Teresa, Carrió, Juan Carlos, Vera, Mar, Ballesteros, Juan, Ayerdi, Oskar, Baza, Begoña, Orviz, Eva, Antela, Antonio, Losada, Elena, Riera, Melchor, Peñaranda, María, Ribas, M. Angels, Campins, Antoni A., Garcia-Gazalla, Mercedes, Fanjul, Francisco J., Murillas, Javier, Homar, Francisco, Vilchez, Helem H., Martin, Luisa, Payeras, Antoni, Santos, Jesús, López, María, Gómez, Crisitina, Viciana, Isabel, Palacios, Rosario, López-Cortés, Luis Fernando, Espinosa, Nuria, Roca, Cristina, Llaves, Silvia, Tiraboschi, Juan Manuel, Imaz, Arkaitz, Silva, Ana Karina, Saumoy, María, Scévola, Sofía Catalina, Curran, Adrián, Falcó, Vicenç, Navarro, Jordi, Burgos, Joaquin, Suanzes, Paula, García, Jorge, Descalzo, Vicente, Álvarez, Patricia, Planas, Bibiana, Sanchiz, Marta, Rodríguez, Lucía, Olalla, Julián, Sánchez, M José, Pérez, Javier, Arco, Alfonso del, Torre, Javier de la, Prada, José Luis, Martínez, Onofre Juan, Martinez, Lorena, Vera, Francisco Jesús, García, Josefina, Alcaraz, Begoña, Sánchez Guirao, Antonio Jesús, Mena, Alvaro, Castro, Angeles, Pernas, Berta, Vázquez, Pilar, López, Soledad, Ibarra, Sofía, García, Guillermo, Mirena, Josu, Ferrero, Oscar Luis, López, Josefina, Cámara, M. Mar, Peña, Mireia de la, Lopez, Miriam, Lopez, Iñigo, Lombide, Itxaso, Polo, Victor, de Miguel, Joana, Galera, Carlos, Fernández, Marian, Albendin, Helena, Castillo, Antonia, Iborra, Asunción, Moreno, Antonio, Merlos, M. Angustias, Vidal, Asunción, Amador, Concha, Pasquau, Francisco, Gil, Concepcion, Algado, Jose Tomás, Suarez-García, Inés, Malmierca, Eduardo, González-Ruano, Patricia, Ruiz, M. Pilar, Pascual, José Francisco, Sáez, Elena, Balsalobre, Luz, López, M. Villa, Omar, Mohamed, Herrero, Carmen, Gómez, M. Amparo, Alberto de Zarraga, Miguel, Pérez, Desiré, Estrada, Vicente, Sanz, Nieves, Cabello, Noemí, García, Jorge Vergas, Núñez, Maria Jose, Sagastagoitia, Iñigo, Górgolas, Miguel, Cabello, Alfonso, Álvarez, Beatriz, Prieto, Laura, Carrillo, Irene, Sanz, José, Arranz, Alberto, Hernández, Cristina, Novella, María, Galindo, M. José, Ferrer, Ana, Román, Antonio Rivero, Ruíz, Inma, Juárez, Antonio Rivero, López, Pedro, Machuca, Isabel, Frias, Mario, Camacho, Ángela, Pérez, Ignacio, Corona, Diana, Cervero, Miguel, Torres, Rafael, Pineda, Juan Antonio, Rincón, Pilar, Macías, Juan, Real, Luis Miguel, Corma, Anais, Gonzalez-Serna, Alejandro, Pérez, Alexandre, Morano, Luis, Miralles, Celia, Ocampo, Antonio, Pousada, Guillermo, Patiño, Lucía, Dueñas, Carlos, Gutiérrez, Sara, Tapia, Elena, Novoa, Cristina, Egües, Xjoylin, Telleria, Pablo, Díaz-Álvarez, Jorge, Rosas Cancio-Suarez, Marta, Ron, Raquel, Iribarren, José Antonio, Ruiz Sancho, Andrés, Cabello, Noemi, and Serrano-Villar, Sergio

Published
2023
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8. A 12-week multicomponent exercise program enhances frailty by increasing robustness, improves physical performance, and preserves muscle mass in older adults with HIV: MOVIhNG study

Author

Brañas, Fátima, primary, Díaz-Álvarez, Jorge, additional, Fernández-Luna, Jesús, additional, Vásquez-Brolen, Brian D., additional, García-Molina, Rafael, additional, Moreno, Elena, additional, Ryan, Pablo, additional, Martínez-Sanz, Javier, additional, Luna, Laura, additional, Martínez, Marta, additional, Dronda, Fernando, additional, and Sánchez-Conde, Matilde, additional

Published
2024
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10. A gut microbiome signature for HIV and metabolic dysfunction-associated steatotic liver disease

Author

Martínez Sanz, Javier, Talavera Rodríguez, Alba, Díaz Álvarez, Jorge, Rosas Cancio-Suárez, Marta, Rodríguez Gómez, Juan Miguel, Alba Rubio, Claudio, Montes, María Luisa, Martín Mateos, Rosa, Burgos Santamaría, Diego, Moreno, Santiago, Serrano Villar, Sergio, Sánchez Conde, Matilde, Martínez Sanz, Javier, Talavera Rodríguez, Alba, Díaz Álvarez, Jorge, Rosas Cancio-Suárez, Marta, Rodríguez Gómez, Juan Miguel, Alba Rubio, Claudio, Montes, María Luisa, Martín Mateos, Rosa, Burgos Santamaría, Diego, Moreno, Santiago, Serrano Villar, Sergio, and Sánchez Conde, Matilde

Abstract

Author contributions: JM: Formal Analysis, Investigation, Software, Writing – original draft. AT: Formal Analysis, Investigation, Writing – original draft. JD: Supervision, Writing – review & editing. MC: Writing – review & editing. JR: Formal Analysis, Methodology, Software, Writing – review & editing. CA: Investigation, Writing – review & editing. MM: Writing – review & editing. RM: Writing – review & editing. DB: Writing – review & editing. SM: Writing – review & editing. SS: Conceptualization, Methodology, Validation, Writing – review & editing. MS: Conceptualization, Formal Analysis, Investigation, Methodology, Resources, Supervision, Writing – original draft, Writing – review & editing., Introduction: Metabolic dysfunction-associated steatotic liver disease (MASLD), has emerged as an increasingly recognized problem among people living with HIV (PLWH). The gut-liver axis is considered to be strongly implicated in the pathogenesis of MASLD. We aimed to characterize the gut microbiota composition in PLWH and MASLD and compare it with that of two control groups: PLWH without MASLD and individuals with MASLD without HIV infection. Methods: We collected clinical data and stool samples from participants. Bacterial 16S rRNA genes were amplified, sequenced, and clustered into operational taxonomic unit. Alpha diversity was studied by Shannon and Simpson indexes. To study how different the gut microbiota composition is between the different groups, beta diversity estimation was evaluated by principal coordinate analysis (PCoA) using Bray-Curtis dissimilarity. To further analyze differences in microbiome composition we performed a linear discriminant analysis (LDA) effect size (LEfSe). Results: We included 30 HIV+MASLD+, 30 HIV+MASLD- and 20 HIV-MASLD+ participants. Major butyrate producers, including Faecalibacterium, Ruminococcus, and Lachnospira dominated the microbiota in all three groups. Shannon’s and Simpson’s diversity metrics were higher among MASLD+ individuals (Kruskal-Wallis p = 0.047). Beta diversity analysis showed distinct clustering in MASLD-, with MASLD+ participants overlapping regardless of HIV status (ADONIS significance <0.001). MASLD was associated with increased homogeneity across individuals, in contrast to that observed in the HIV+NAFDL- group, in which the dispersion was higher (Permanova test, p value <0.001; ANOSIM, p value <0.001). MASLD but not HIV determined a different microbiota structure (HIV+MASLD- vs. HIV+MASLD+, q-value = 0.002; HIV-MASLD+ vs. HIV+MASLD+, q-value = 0.930; and HIV-MASLD+ vs. HIV+MASLD-, q-value < 0.001). The most abundant genera in MASLD- were Prevotella, Bacteroides, Dialister, Acidaminococcos, Alloprevotel, Ministerio de Ciencia, Innovación y Universidades (España), Sección Dptal. de Nutrición y Ciencia de los Alimentos (Veterinaria), Fac. de Veterinaria, TRUE, pub

Published
2024

11. Proteomic snapshot of saliva samples predicts new pathways implicated in SARS-CoV-2 pathogenesis

Author

Instituto de Salud Carlos III, Conferencia de Rectores de las Universidades Españolas, Fundación Científica Asociación Española Contra el Cáncer, Consejo Superior de Investigaciones Científicas (España), European Commission, Agencia Estatal de Investigación (España), Ministerio de Ciencia, Innovación y Universidades (España), Ministerio de Ciencia e Innovación (España), Corrales, Fernando J. [0000-0002-0231-5159], Moreno, Elena, Ciordia, Sergio, Fátima, Santos Milhano, Jiménez, Daniel, Martínez-Sanz, Javier, Vizcarra, Pilar, Ron, Raquel, Sánchez-Conde, Matilde, Bargiela, Rafael, Sanchez-Carrillo, Sergio, Moreno, Santiago, Corrales, Fernando J., Ferrer, Manuel, Serrano-Villar, Sergio, Instituto de Salud Carlos III, Conferencia de Rectores de las Universidades Españolas, Fundación Científica Asociación Española Contra el Cáncer, Consejo Superior de Investigaciones Científicas (España), European Commission, Agencia Estatal de Investigación (España), Ministerio de Ciencia, Innovación y Universidades (España), Ministerio de Ciencia e Innovación (España), Corrales, Fernando J. [0000-0002-0231-5159], Moreno, Elena, Ciordia, Sergio, Fátima, Santos Milhano, Jiménez, Daniel, Martínez-Sanz, Javier, Vizcarra, Pilar, Ron, Raquel, Sánchez-Conde, Matilde, Bargiela, Rafael, Sanchez-Carrillo, Sergio, Moreno, Santiago, Corrales, Fernando J., Ferrer, Manuel, and Serrano-Villar, Sergio

Abstract

Background Information on the microbiome's human pathways and active members that can affect SARS-CoV-2 susceptibility and pathogenesis in the salivary proteome is very scarce. Here, we studied a unique collection of samples harvested from April to June 2020 from unvaccinated patients. Methods We compared 10 infected and hospitalized patients with severe (n = 5) and moderate (n = 5) coronavirus disease (COVID-19) with 10 uninfected individuals, including non-COVID-19 but susceptible individuals (n = 5) and non-COVID-19 and nonsusceptible healthcare workers with repeated high-risk exposures (n = 5). Results By performing high-throughput proteomic profiling in saliva samples, we detected 226 unique differentially expressed (DE) human proteins between groups (q-value ≤ 0.05) out of 3376 unambiguously identified proteins (false discovery rate ≤ 1%). Major differences were observed between the non-COVID-19 and nonsusceptible groups. Bioinformatics analysis of DE proteins revealed human proteomic signatures related to inflammatory responses, central cellular processes, and antiviral activity associated with the saliva of SARS-CoV-2-infected patients (p-value ≤ 0.0004). Discriminatory biomarker signatures from human saliva include cystatins, protective molecules present in the oral cavity, calprotectins, involved in cell cycle progression, and histones, related to nucleosome functions. The expression levels of two human proteins related to protein transport in the cytoplasm, DYNC1 (p-value, 0.0021) and MAPRE1 (p-value, 0.047), correlated with angiotensin-converting enzyme 2 (ACE2) plasma activity. Finally, the proteomes of microorganisms present in the saliva samples showed 4 main microbial functional features related to ribosome functioning that were overrepresented in the infected group. Conclusion Our study explores potential candidates involved in pathways implicated in SARS-CoV-2 susceptibility, although further studies in larger cohorts will be necessary.

Published
2024

12. Design and Proof of Concept of a Web-Based Questionnaire to Identify Patients at Risk for HIV and HCV Infection.

Author

García-Ruiz de Morales, Alejandro G., Vivancos, María Jesús, Lázaro, Jorge, Romero Hernández, Beatriz, Mateos, Beatriz, Pérez-Elías, Pilar, Herrero Delgado, Margarita, Villanova Cuadra, Laura, Moreno, Santiago, Martínez-Sanz, Javier, and Pérez-Elías, María Jesús

Subjects
HIV infections, HIV, HEPATITIS C virus, DELAYED diagnosis, PRE-exposure prophylaxis
Abstract

Despite remarkable improvement in the human immunodeficiency virus (HIV) and hepatitis C virus (HCV) care continuum, the rate of late diagnosis of HIV and HCV in high-income countries remains unacceptably high. Testing relies mainly on primary care physicians' identification of risk factors. We aimed to adapt an analogic to an online questionnaire to help HIV and HCV screening and perform a pilot study to assess its accuracy and acceptability. We used the Delphi method to adapt a previously validated analogical questionnaire to a user-friendly online tool. It aimed to identify participants who should be screened for HIV or HCV and those who should be referred for pre-exposure prophylaxis (PrEP). We then designed a proof-of-concept pilot study from July to October 2022 to test its feasibility and suitability for use on a larger scale and to assess its accuracy in identifying patients at risk for HIV or HCV or with indication for PrEP. The final questionnaire consisted of 37 questions. A total of 142 participants provided informed consent, and 102 completed the questionnaire: 41 random patients recruited at the primary care level, 10 participants recently diagnosed with HIV, 20 participants with HIV on follow-up, 21 participants from the PrEP program, and 10 patients diagnosed with HCV. The tool adequately indicated the need for testing in more than 98% of participants with confirmed HIV/HCV infections or in the PrEP program. Furthermore, it adequately assessed PrEP referral in 94% of participants already on PrEP or with known HIV infection. Participants were highly satisfied with the tool, and 98% of them recommended its use. A self-administered web-based tool to identify patients who should be tested for HIV or HCV or referred to PrEP could simplify patient selection and help reduce late diagnosis. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Corrigendum: CD4/CD8 ratio and CD8+ T-cell count as prognostic markers for non-AIDS mortality in people living with HIV. A systematic review and meta-analysis

Author

Ron, Raquel, primary, Martínez-Sanz, Javier, additional, Herrera, Sabina, additional, Ramos-Ruperto, Luis, additional, Díez-Vidal, Alejandro, additional, Sainz, Talía, additional, Álvarez-Díaz, Noelia, additional, Correa-Pérez, Andrea, additional, Muriel, Alfonso, additional, López-Alcalde, Jesús, additional, Pérez-Molina, José A., additional, Moreno, Santiago, additional, and Serrano-Villar, Sergio, additional

Published
2024
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14. CD4/CD8 ratio and CD8+ T-cell count as prognostic markers for non-AIDS mortality in people living with HIV. A systematic review and meta-analysis

Author

Ron, Raquel, primary, Martínez-Sanz, Javier, additional, Herrera, Sabina, additional, Ramos-Ruperto, Luis, additional, Díez, Alejandro, additional, Sainz, Talía, additional, Álvarez-Díaz, Noelia, additional, Correa-Pérez, Andrea, additional, Muriel, Alfonso, additional, López-Alcalde, Jesús, additional, Pérez-Molina, José A., additional, Moreno, Santiago, additional, and Serrano-Villar, Sergio, additional

Published
2024
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18. Effects of first-line antiretroviral therapy on the CD4/CD8 ratio and CD8 cell counts in CoRIS: a prospective multicentre cohort study

Author

Jarrin, Inmaculada, Moreno, Santiago, Alejos, Belén, Muñoz-Fernández, MÁngeles, Consuegra, Irene, Merino, Esperanza, García, Gema, Lirola, Ana López, García, Dácil, Asensi, Víctor, Valle, Eulalia, Rubio, Rafael, Pulido, Federico, Iribarren, José Antonio, Arrizabalaga, Julio, Gutiérrez, Félix, Masiá, Mar, Muga, Roberto, Sanvisens, Arantza, Berenguer, Juan, Vidal, Francesc, Montero, Marta, Blanco, José Ramón, López Bernarlo de Quirós, Juan Carlos, González-Garcia, Juan, Peraire, Joaquín, Arazo, Piedad, López-Aldeguer, José, Dalmau, David, Arnalich, Francisco, Rivero, Maria, Oteo, José Antonio, Sampériz, Gloria, Amengual, María José, Jaén, Angels, de los Santos, Ignacio, Repáraz, Jesús, Navarro, Gemma, Bernal, Enrique, Sanz, Jesús, Viciana, Pompeyo, García, Federico, Casado, José Luis, Del Romero, Jorge, Cano, Alfredo, Antela, Antonio, Quero, José Hernández, Riera, Melchor, Raposo, Montserrat, Santos, Jesús, Losada, Elena, Daniel, Podzamczer, Peñaranda, María, Ayerbe, Cristina Gómez, Espinosa, Nuria, Olalla, Julián, Imaz, Arkaitz, Martínez, Onofre, Curran, Adrian, Castro, Ángeles, Pérez Stachowski, Javier, Muñoz, Josefa, Vera, Francisco Jesús, Galera, Carlos, Pernas, Berta, Amador, Concha, Zuriñe, Miren, Albendin, Helena, Suárez-García, Inés, Pasquau, Francisco, Omar, Mohamed, Malmierca, Eduardo, de Zarraga, Miguel Alberto, Gómez Vidal, María Amparo, Estrada, Vicente, Górgolas, Miguel, Sanz, José, Téllez, María Jesús, Galindo, María José, Cabello, Alfonso, Rivero, Antonio, Arranz, Alberto, Cervero, Miguel, Vilalta, Ramón, Pineda, Juan A, Rivero-Juárez, Antonio, Torres, Rafael, Poveda, Eva, Rincón, Pilar, Pérez, Alexandre, Moreno, Cristina, Portilla, Irene, Díaz-Flores, Felicitas, Rivas, María E, Bisbal, Otilia, Aramburu, María J, Padilla, Sergio, Fuster, Daniel, Gutiérrez, Isabel, Viladés, Consuelo, Blanes, Marino, Arribas, José Ramón, Ibarra, Valvanera, Sanmartí, Montse, de Alda, María Ruiz, Cervantes, Manel, Salas, Ana, Dronda, Fernando, Alcaraz, Antonia, Muñoz, Leopoldo, Rodríguez, Carmen, Ribas, María Angels, Viciana, Isabel, López-Cortés, Luis, Tiraboschi, Juan, del Arco, Alfonso, Martínez, Lorena, Mena, Álvaro, Mirena, Josu, Pérez, Aurora, Ena, Javier, González-Ruano, Patricia, Vergas, Jorge, Álvarez, Beatriz, Hernández, Cristina, Ferrer, Ana, López, Pedro, Macías, Juan, Crespo, Manuel, Navarro, Maria Luisa, Iniesta, Carlos, Agea, Iván, Gómez, Juan Luis, Suárez-Zarracina, Tomás, Hernando, Asunción, Camino, Xabier, Robledano, Catalina, Ramírez, Margarita, Veloso, Sergio, Tasias, María, Bernardino, Jose Ignacio, Metola, Luis, Cairó, Mireia, de León Cano, María Teresa, Calzado, Sonia, Sarria, Cristina, Moreno, Ana, Bravo, Joaquín, Alvarez, Marta, Puerta, Teresa, Campins, Antoni A, Palacios, Rosario, Silva, Ana, de la Torre, Javier, García, Josefina, Ibarra, Sofía, Iborra, Asunción, Benito, Concha, Martín, Dolores, Pérez-Somarriba, Juncal, Prieto, Laura, Novella, María, Machuca, Isabel, Merchante, Nicolás, Morano, Luis, González, Maria Isabel, García, Luis NM, Portilla, Joaquín, Alonso, María del Mar, Pérez, Laura, Domínguez, Lourdes, Rodríguez-Arrondo, Francisco, Colomé, Joan Gregori, Padilla, Belén, Vargas, Montserrat, Castro, Iván, Castro, Juan Miguel, Sanz, Mercedes, Martinez-Lacasa, Javier, Pierola, Beatriz, Navarro, Marta, Garcia-Fraile, Lucio, Pérez-Elias, Maria Jesús, Muñoz, Ángeles, Chueca, Natalia, Carrió, Juan Carlos, Vidal, Carmen, Pérez, Carmen, Saumoy, María, Prada, José Luis, Alcaraz, Begoña, Ferrero, Oscar, Moreno, Antonio, Fenoll, Vicenta, Ruiz, Mª Pilar, Frias, Mario, Real, Luis Miguel, Miralles, Celia, Garcia, Federico, Sanz, Nieves, Sánchez-Payá, José, Pelazas, Ricardo, Rial, David, von Wichman, Miguel Ángel, Adsuar, Araceli, Gijón, Paloma, Olona, Montserrat, Calabuig, Eva, Delgado, Ana, Pérez-Martínez, Laura, Velli, Pablo, Martín-Gayo, Enrique, Gutiérrez, Carolina, Alcaraz, Maria José, Vinuesa, David, Vera, Mar, Fanjul, Francisco, Gonzalez-Domenec, Carmen, Prieto, Paula, de las Lomas, José N García, Jimeno, Amaya, López, Josefina, Merlos, Maria, Gil, Concepción, Camacho, Angela, Corma, Anais, Ocampo, Antonio, Rava, Marta, Rodríguez, Juan Carlos, Hernández, Jehovana, Bermejo, Laura, Pascual, Lidia, Pascual, Rafael, Aldamiz-Echevarría, Teresa, Rull, Anna, Cuéllar, Sandra, Escosa, Luis, Font, Roser, Madrid, Nadia, del Carmen Villalba, Maria, Martinez-Montes, Clara, Ballesteros, Juan, Murillas, Javier, Cámara, María Mar, Vidal, Asunción, Algado, José Tomas, Fernández, Marta, Pousada, Guillermo, Iribarren, Jose Antonio, Gimeno, Lina, Alemán, María Remedios, Santacreu, Mireia, Goenaga, Miguel Ángel, Tejerina, Francisco, Rodríguez-Gallego, Esther, Salavert, Miguel, Herranz, Pedro, Martinez, Marina, del Campo, Santos, Guerrero, Carlos, Ayerdi, Oskar, Homar, Francisco, de la Peña, Mireia, Meca, Marisa, Díez, Marcos, Azkune, Harkaitz, Barber, Xavier, Balsalobre, Pascual, Castellanos, Alfonso Javier, García-Bujalance, Silvia, Vivancos, Maria Jesús, Fuentes, Ana, Martin, Maria Luisa, Lopez, Iñigo, Vilchez, Helem, Lopez, Miriam, Carreres, Melissa, Ibarguren, Maialen, Agullo, Vanessa, Diez, Cristina, López-Dupla, Miguel, García, Milagros, Umerez, Maitane, Martínez-Sanz, Javier, Payeras, Antoni, Reus, Sergio, Lizardi, Aitziber, Garcia, Javier, Pérez, Leire, González-Baeza, Alicia, Anxa, Usua, González, Juan, Boix, Vicente, Kortajarena, Xabier, Pascual, Reyes, Fanciulli, Chiara, Martín-Carbonero, Maria Luz, Mellado, Maria José, Micán, Rafael, Montejano, Rocio, Montes, María Luisa, Moreno, Victoria, Pérez-Valero, Ignacio, Rúa, Guadalupe, Rodés, Berta, Sainz, Talia, Sendagorta, Elena, Stella, Natalia, Valencia, Eulalia, Velasco, Tamara, Muñoz-Fernández, María Ángeles, Torrús, Diego, Carmona, María Pilar, Roca, María, Mayoral, Mario, Vallejo, Alejandro, Serrano-Villar, Sergio, Ron, Raquel, Talavera-Rodríguez, Alba, Fernández-Felix, Borja M, Herrera, Sabina, Muriel, Alfonso, de Zárraga, Miguel Alberto, and Vivancos, María J

Published
2020
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19. Description of COVID-19 in HIV-infected individuals: a single-centre, prospective cohort

Author

Moreno, Santiago, Pérez-Elías, Maria Jesús, Fortún, Jesús, Navas, Enrique, Quereda, Carmen, Dronda, Fernando, Del Campo, Santos, López-Vélez, Rogelio, Cobo Reinoso, Javier, Casado, José Luis, Moreno, Ana, Norman, Franceca, Martín-Dávila, Pilar, Hermida, José Manuel, Pérez Molina, José Antonio, Monge, Begoña, Pintado, Vicente, Serrano-Villar, Sergio, Sánchez-Conde, Matilde, Chamorro, Sandra, Escudero, Rosa, Gioia, Francesca, Comeche, Belén, Crespillo, Clara, Herrera, Sabina, Ron, Raquel, Martínez-Sanz, Javier, Pons-Guillén, Mario, Vivancos, María Jesús, Vizcarra, Pilar, Pérez-Elías, María J, Vivancos, María J, and Casado, José L

Published
2020
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21. Expanding HIV clinical monitoring: the role of CD4, CD8, and CD4/CD8 ratio in predicting non-AIDS events

Author

Martínez-Sanz, Javier, primary, Díaz-Álvarez, Jorge, additional, Rosas Cancio-Suarez, Marta, additional, Ron, Raquel, additional, Iribarren, José Antonio, additional, Bernal, Enrique, additional, Gutiérrez, Félix, additional, Ruiz Sancho, Andrés, additional, Cabello, Noemi, additional, Olalla, Julián, additional, Moreno, Santiago, additional, Serrano-Villar, Sergio, additional, Jarrín, Inma, additional, Dalmau, David, additional, Navarro, M. Luisa, additional, González, M. Isabel, additional, Garcia, Federico, additional, Poveda, Eva, additional, Iribarren, Jose Antonio, additional, Rubio, Rafael, additional, Vidal, Francesc, additional, Berenguer, Juan, additional, González, Juan, additional, Muñoz-Fernández, M. Ángeles, additional, Jarrín, Inmaculada, additional, Moreno, Cristina, additional, Rava, Marta, additional, Izquierdo, Rebeca, additional, Mauleón, Elba, additional, Portilla, Joaquín, additional, Portilla, Irene, additional, Merino, Esperanza, additional, García, Gema, additional, Agea, Iván, additional, Sánchez-Payá, José, additional, Rodríguez, Juan Carlos, additional, Giner, Livia, additional, Reus, Sergio, additional, Boix, Vicente, additional, Torrus, Diego, additional, Pérez, Verónica, additional, Portilla, Julia, additional, Gómez, Juan Luís, additional, Hernández, Jehovana, additional, Lirola, Ana López, additional, García, Dácil, additional, Díaz-Flores, Felicitas, additional, Alonso, M. Mar, additional, Pelazas, Ricardo, additional, Alemán, M. Remedios, additional, Asensi, Víctor, additional, Rivas Carmenado, María Eugenia, additional, Suarez-Zarracina, Tomás, additional, Pulido, Federico, additional, Bisbal, Otilia, additional, Hernando, M. Asunción, additional, Rial, David, additional, de Lagarde, María, additional, Arce, Octavio, additional, Pinto, Adriana, additional, Bermejo, Laura, additional, Santacreu, Mireia, additional, Navarro, Roser, additional, Gonzalez, Candela, additional, Aramburu, M. José, additional, Camino, Xabier, additional, Ángel von Wichmann, Miguel, additional, Goenaga, Miguel Ángel, additional, Bustinduy, M. Jesús, additional, Azkune, Harkaitz, additional, Ibarguren, Maialen, additional, Kortajarena, Xabier, additional, Álvarez-Rodriguez, Ignacio, additional, Gil, Leire, additional, Martínez, Lourdes, additional, Robledano, Catalina, additional, Masiá, Mar, additional, Padilla, Sergio, additional, Adsuar, Araceli, additional, Pascual, Rafael, additional, Fernández, Marta, additional, Galiana, Antonio, additional, García, José Alberto, additional, Barber, Xavier, additional, Agullo, Vanessa, additional, Abellán, Javier Garcia, additional, Pascual, Reyes, additional, Telenti, Guillermo, additional, Guillén, Lucia, additional, Botella, Ángela, additional, Muga, Roberto, additional, Sanvisens, Arantza, additional, Fuster, Daniel, additional, Gutierrez, Isabel, additional, López, Juan Carlos, additional, Ramírez, Margarita, additional, Padilla, Belén, additional, Gijón, Paloma, additional, Aldamiz-Echevarría, Teresa, additional, Tejerina, Francisco, additional, Diez, Cristina, additional, Pérez, Leire, additional, Fanciulli, Chiara, additional, Corral, Saray, additional, Martí, Anna, additional, Peraire, Joaquín, additional, Viladés, Consuelo, additional, Vargas, Montserrat, additional, Olona, Montserrat, additional, Rull, Anna, additional, Alba, Verónica, additional, Yeregui, Elena, additional, Masip, Jenifer, additional, García-Pardo, Graciano, additional, Bertomeu, Frederic Gómez, additional, Espineira, Sonia, additional, Montero, Marta, additional, Cuéllar, Sandra, additional, Blanes, Marino, additional, Tasias, María, additional, Calabuig, Eva, additional, Salavert, Miguel, additional, Fernández, Juan, additional, Segarra, Inmaculada, additional, González-García, Juan, additional, Delgado, Ana, additional, Arnalich, Francisco, additional, Arribas, José Ramón, additional, Bernardino, Jose Ignacio, additional, Castro, Juan Miguel, additional, Escosa, Luis, additional, Herranz, Pedro, additional, Hontañón, Victor, additional, García-Bujalance, Silvia, additional, García, Milagros, additional, González-Baeza, Alicia, additional, Martín-Carbonero, M. Luz, additional, Mayoral, Mario, additional, Mellado, M. Jose, additional, Esteban, Rafael, additional, Montejano, Rocío, additional, Montes, M. Luisa, additional, Moreno, Victoria, additional, Pérez-Valero, Ignacio, additional, Rodés, Berta, additional, Rúa, Guadalupe, additional, Sainz, Talía, additional, Sendagorta, Elena, additional, Valencia, Eulalia, additional, Busca, Carmen, additional, Cano, Joanna, additional, Cardiñanos, Julen, additional, de Miguel, Rosa, additional, Blanco, Jose Ramón, additional, Pérez-Martínez, Laura, additional, Oteo, José Antonio, additional, Ibarra, Valvanera, additional, Metola, Luis, additional, Sanz, Mercedes, additional, Arazo, Piedad, additional, Sampériz, Gloria, additional, Martinez, Marina, additional, Jaén, Angels, additional, Sanmartí, Montse, additional, Cairó, Mireia, additional, Martinez-Lacasa, Javier, additional, Velli, Pablo, additional, Font, Roser, additional, Xercavins, Mariona, additional, Alonso, Noemí, additional, Aiello, Francesco, additional, Rivero, María, additional, Piérola, Beatriz, additional, Goikoetxea, Maider, additional, Gracia, María, additional, Ibero, Carlos, additional, Moreno, Estela, additional, Repáraz, Jesús, additional, Navarro, Gemma, additional, Garcia, Manel Cervantes, additional, Isbert, Sonia Calzado, additional, Vilasaro, Marta Navarro, additional, Garcia, Belen Lopez, additional, Santos, Ignacio de los, additional, Santos, Alejandro de los, additional, Sanz, Jesús, additional, García-Fraile, Lucio, additional, Martín, Enrique, additional, Sánchez-Cerrillo, Ildefonso, additional, Calvet, Marta, additional, Barrios, Ana, additional, Bautista, Azucena, additional, Sáez, Carmen, additional, Ciudad, Marianela, additional, Gutiérrez, Ángela, additional, Campo, Santos del, additional, Casado, José Luis, additional, Dronda, Fernando, additional, Moreno, Ana, additional, Pérez, M. Jesús, additional, Serrano, Sergio, additional, Vivancos, Ma Jesús, additional, Martínez-Sanz, Javier, additional, Vallejo, Alejandro, additional, Sanchez, Matilde, additional, Pérez-Molina, Jose Antonio, additional, Hermida, José Manuel, additional, Alcaraz, Antonia, additional, Bravo, Joaquín, additional, Muñoz, Ángeles, additional, Tomás, Cristina, additional, Martínez, Mónica, additional, Villalba, M. Carmen, additional, García, Federico, additional, Martínez, Clara, additional, Hernández, José, additional, Medina, Leopoldo Muñoz, additional, Álvarez, Marta, additional, Chueca, Natalia, additional, Vinuesa, David, additional, de Salazar, Adolfo, additional, Fuentes, Ana, additional, Guirao, Emilio, additional, Viñuela, Laura, additional, Ruiz-Sancho, Andrés, additional, Anguita, Francisco, additional, Del Romero, Jorge, additional, Raposo, Montserrat, additional, Rodríguez, Carmen, additional, Puerta, Teresa, additional, Carrió, Juan Carlos, additional, Vera, Mar, additional, Ballesteros, Juan, additional, Ayerdi, Oskar, additional, Baza, Begoña, additional, Orviz, Eva, additional, Antela, Antonio, additional, Losada, Elena, additional, Riera, Melchor, additional, Peñaranda, María, additional, Ribas, M. Angels, additional, Campins, Antoni A., additional, Garcia-Gazalla, Mercedes, additional, Fanjul, Francisco J., additional, Murillas, Javier, additional, Homar, Francisco, additional, Vilchez, Helem H., additional, Martin, Luisa, additional, Payeras, Antoni, additional, Santos, Jesús, additional, López, María, additional, Gómez, Crisitina, additional, Viciana, Isabel, additional, Palacios, Rosario, additional, López-Cortés, Luis Fernando, additional, Espinosa, Nuria, additional, Roca, Cristina, additional, Llaves, Silvia, additional, Tiraboschi, Juan Manuel, additional, Imaz, Arkaitz, additional, Silva, Ana Karina, additional, Saumoy, María, additional, Scévola, Sofía Catalina, additional, Curran, Adrián, additional, Falcó, Vicenç, additional, Navarro, Jordi, additional, Burgos, Joaquin, additional, Suanzes, Paula, additional, García, Jorge, additional, Descalzo, Vicente, additional, Álvarez, Patricia, additional, Planas, Bibiana, additional, Sanchiz, Marta, additional, Rodríguez, Lucía, additional, Sánchez, M José, additional, Pérez, Javier, additional, Arco, Alfonso del, additional, Torre, Javier de la, additional, Prada, José Luis, additional, Martínez, Onofre Juan, additional, Martinez, Lorena, additional, Vera, Francisco Jesús, additional, García, Josefina, additional, Alcaraz, Begoña, additional, Sánchez Guirao, Antonio Jesús, additional, Mena, Alvaro, additional, Castro, Angeles, additional, Pernas, Berta, additional, Vázquez, Pilar, additional, López, Soledad, additional, Ibarra, Sofía, additional, García, Guillermo, additional, Mirena, Josu, additional, Ferrero, Oscar Luis, additional, López, Josefina, additional, Cámara, M. Mar, additional, Peña, Mireia de la, additional, Lopez, Miriam, additional, Lopez, Iñigo, additional, Lombide, Itxaso, additional, Polo, Victor, additional, de Miguel, Joana, additional, Galera, Carlos, additional, Fernández, Marian, additional, Albendin, Helena, additional, Castillo, Antonia, additional, Iborra, Asunción, additional, Moreno, Antonio, additional, Merlos, M. Angustias, additional, Vidal, Asunción, additional, Amador, Concha, additional, Pasquau, Francisco, additional, Gil, Concepcion, additional, Algado, Jose Tomás, additional, Suarez-García, Inés, additional, Malmierca, Eduardo, additional, González-Ruano, Patricia, additional, Ruiz, M. Pilar, additional, Pascual, José Francisco, additional, Sáez, Elena, additional, Balsalobre, Luz, additional, López, M. Villa, additional, Omar, Mohamed, additional, Herrero, Carmen, additional, Gómez, M. Amparo, additional, Alberto de Zarraga, Miguel, additional, Pérez, Desiré, additional, Estrada, Vicente, additional, Sanz, Nieves, additional, Cabello, Noemí, additional, García, Jorge Vergas, additional, Núñez, Maria Jose, additional, Sagastagoitia, Iñigo, additional, Górgolas, Miguel, additional, Cabello, Alfonso, additional, Álvarez, Beatriz, additional, Prieto, Laura, additional, Carrillo, Irene, additional, Sanz, José, additional, Arranz, Alberto, additional, Hernández, Cristina, additional, Novella, María, additional, Galindo, M. José, additional, Ferrer, Ana, additional, Román, Antonio Rivero, additional, Ruíz, Inma, additional, Juárez, Antonio Rivero, additional, López, Pedro, additional, Machuca, Isabel, additional, Frias, Mario, additional, Camacho, Ángela, additional, Pérez, Ignacio, additional, Corona, Diana, additional, Cervero, Miguel, additional, Torres, Rafael, additional, Pineda, Juan Antonio, additional, Rincón, Pilar, additional, Macías, Juan, additional, Real, Luis Miguel, additional, Corma, Anais, additional, Gonzalez-Serna, Alejandro, additional, Pérez, Alexandre, additional, Morano, Luis, additional, Miralles, Celia, additional, Ocampo, Antonio, additional, Pousada, Guillermo, additional, Patiño, Lucía, additional, Dueñas, Carlos, additional, Gutiérrez, Sara, additional, Tapia, Elena, additional, Novoa, Cristina, additional, Egües, Xjoylin, additional, and Telleria, Pablo, additional

Published
2023
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23. Life expectancy of people with HIV on antiretroviral therapy in Spain

Author

Jarrín, Inma, primary, Rava, Marta, additional, Raposo, Jorge Del Romero, additional, Rivero, Antonio, additional, Del Romero Guerrero, Jorge, additional, De Lagarde, María, additional, Martínez Sanz, Javier, additional, Navarro, Gemma, additional, Dalmau, David, additional, Blanco, José Ramón, additional, Koerting, Ana, additional, Gomez Castell, Javier, additional, and Del Amo, Julia, additional

Published
2023
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24. Description of mpox reinfection by whole genome sequencing

Author

Martínez-Sanz, Javier, primary, Ponce, Manuel, additional, Martínez-García, Laura, additional, de la Cueva, Víctor, additional, Olavarrieta, Leticia, additional, Montero, Laura, additional, Pérez-Elías, María Jesús, additional, and Galán, Juan Carlos, additional

Published
2023
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25. Fecal microbiota transplantation in HIV: A pilot placebo-controlled study

Author

Serrano-Villar, Sergio, Talavera-Rodríguez, Alba, Gosalbes, María José, Madrid, Nadia, Pérez-Molina, José A., Elliott, Ryan J., Navia, Beatriz, Lanza, Val F., Vallejo, Alejandro, Osman, Majdi, Dronda, Fernando, Budree, Shrish, Zamora, Javier, Gutiérrez, Carolina, Manzano, Mónica, Vivancos, María Jesús, Ron, Raquel, Martínez-Sanz, Javier, Herrera, Sabina, Ansa, Uxua, Moya, Andrés, and Moreno, Santiago

Published
2021
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26. Proteomic snapshot of saliva samples predicts new pathways implicated in SARS-CoV-2 pathogenesis

Author

Olmo, Elena Moreno del, primary, Ciordia, Sergio, additional, Santos, Fátima Millhano, additional, Jiménez, Daniel, additional, Martínez-Sanz, Javier, additional, Vizcarra, Pilar, additional, Ron, Raquel, additional, Sánchez-Conde, Matilde, additional, Bargiela, Rafael, additional, Sanchez-Carrillo, Sergio, additional, Moreno, Santiago, additional, Corrales, Fernando José, additional, Ferrer, Manuel, additional, and Serrano-Villar, Sergio, additional

Published
2023
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27. Incidence of Anal Cancer and Related Risk Factors in HIV-Infected Patients Enrolled in the National Prospective Spanish Cohort CoRIS

Author

Cudós, Elena Sendagorta, primary, De La Piedra, César Sotomayor, additional, Canuto, Mar Masia, additional, Úbeda, Alfonso Cabello, additional, Curran, Adrian, additional, Hermida, Antonio Ocampo, additional, Rava, Marta, additional, Muriel, Alfonso, additional, Macías, Juan, additional, Rial-Crestelo, David, additional, Martínez-Sanz, Javier, additional, Martinez, Lorena, additional, De La Villa López-Sánchez, María, additional, and Perez-Molina, José A., additional

Published
2023
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29. HIV and HCV screening by non-infectious diseases physicians: can we improve testing and hidden infection rates?

Author

García-Ruiz de Morales, Alejandro G., primary, Martínez-Sanz, Javier, additional, Vivancos-Gallego, María J., additional, Sánchez-Conde, Matilde, additional, Vélez-Díaz-Pallarés, Manuel, additional, Romero-Hernández, Beatriz, additional, Vázquez, María Dolores González, additional, de Luque, Carmen María Cano, additional, González-Sarria, Ander, additional, Galán, Juan Carlos, additional, Rodríguez, Francisco Gea, additional, Moreno, Santiago, additional, and Pérez-Elías, María Jesús, additional

Published
2023
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30. Impact of COVID-19 on the Care of Patients with HIV Infection

Author

Rosas Cancio-Suárez, Marta, primary, Alonso, Cecilia, additional, Vivancos, María Jesús, additional, Pérez-Elías, María Jesús, additional, Cárdenas, María José, additional, Vélez-Díaz-Pallarés, Manuel, additional, Corbacho, María Dolores, additional, Martín-Pedraza, Laura, additional, Muriel, Alfonso, additional, Martínez-Sanz, Javier, additional, and Moreno, Santiago, additional

Published
2023
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31. Differential abundance of lipids and metabolites related to SARS- CoV-2 infection and susceptibility

Author

Albóniga, Oihane E., primary, Olmo, Elena Moreno del, additional, Martínez-Sanz, Javier, additional, Vizcarra, Pilar, additional, Ron, Raquel, additional, Diaz, Jorge, additional, Rosas, Marta, additional, Sánchez-Conde, Matilde, additional, Galán, Juan Carlos, additional, Angulo, Santiago, additional, Moreno, Santiago, additional, Barbas, Coral, additional, and Serrano-Villar, Sergio, additional

Published
2023
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33. Global DNA methylation and telomere length as markers of accelerated ageing in non-alcoholic fatty liver disease patients with HIV infection

Author

Moreno, Elena, primary, Martínez-Sanz, Javier, additional, Martín-Mateos, Rosa, additional, Díaz-Álvarez, Jorge, additional, Serrano-Villar, Sergio, additional, Burgos-Santamaría, Diego, additional, Luna, Laura, additional, Vivancos, María Jesús, additional, Moreno-Zamora, Ana, additional, Pérez-Elías, María Jesús, additional, Moreno, Santiago, additional, Dronda, Fernando, additional, Montes, María Luisa, additional, and Sánchez-Conde, Matilde, additional

Published
2023
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34. Differences in saliva ACE2 activity among infected and non-infected adult and pediatric population exposed to SARS-CoV-2

Author

Instituto de Salud Carlos III, Conferencia de Rectores de las Universidades Españolas, European Commission, Martínez-Sanz, Javier [0000-0003-2020-3908], Moreno, Elena [0000-0002-2301-4558], Vizcarra, Pilar [0000-0001-8553-6995], Rodríguez-Domínguez, Mario [0000-0002-1783-9318], Ron, Raquel [0000-0002-3439-8438], Norman, Francesca [0000-0003-0336-7767], Ferrer, Manuel [0000-0003-4962-4714], Jiménez, Daniel, Martínez-Sanz, Javier, Sainz, Talia, Calvo, Cristina, Méndez-Echevarría, Ana, Moreno, Elena, Blázquez-Gamero, Daniel, Vizcarra, Pilar, Rodríguez-Domínguez, Mario, Jenkins, Robert, Sánchez-Conde, Matilde, Ron, Raquel, Norman, Francesca, Moreno, Santiago, Ferrer, Manuel, Serrano-Villar, Sergio, Instituto de Salud Carlos III, Conferencia de Rectores de las Universidades Españolas, European Commission, Martínez-Sanz, Javier [0000-0003-2020-3908], Moreno, Elena [0000-0002-2301-4558], Vizcarra, Pilar [0000-0001-8553-6995], Rodríguez-Domínguez, Mario [0000-0002-1783-9318], Ron, Raquel [0000-0002-3439-8438], Norman, Francesca [0000-0003-0336-7767], Ferrer, Manuel [0000-0003-4962-4714], Jiménez, Daniel, Martínez-Sanz, Javier, Sainz, Talia, Calvo, Cristina, Méndez-Echevarría, Ana, Moreno, Elena, Blázquez-Gamero, Daniel, Vizcarra, Pilar, Rodríguez-Domínguez, Mario, Jenkins, Robert, Sánchez-Conde, Matilde, Ron, Raquel, Norman, Francesca, Moreno, Santiago, Ferrer, Manuel, and Serrano-Villar, Sergio

Abstract

Background Variations in the ACE2 activity in saliva could explain the striking differences of susceptibility to infection and risk of severe disease. Methods We analyze the activity of ACE2 in saliva in different population groups across a wide age range and disease status during April to June 2020, before SARS-CoV-2 vaccine implementation, and we establish differences between infected people and participants considered resistant (highly exposed healthcare workers and children who cohabited with parents with COVID-19 without isolation and remain IgG negative). Results We included 74 adults, of which 47 (64%) were susceptible and 27 (36%) were resistant, and 79 children, of which 41 (52%) were susceptible and 38 (48%) were resistant. Resistant adults have significantly lower ACE2 activity in saliva than susceptible adults and non-significant higher values than susceptible and resistant children. ACE2 activity is similar in the susceptible and resistant pediatric population (p = 0.527). In contrast, we observe an increase in activity as the disease's severity increases among the adult population (mild disease vs. severe disease, 39 vs. 105 FU, p = 0.039; severe disease vs. resistant, 105 vs. 31 FU, p < 0.001). Conclusions using an enzymatic test, we show that ACE2 activity in saliva correlates with the susceptibility to SARS-Cov-2 infection and disease severity. Children and adults with low-susceptibility to SARS-Cov-2 infection showed the lowest ACE2 activity. These findings could inform future strategies to identify at-risk individuals.

Published
2022

36. COVID-19 and geographical area of origin

Author

Vizcarra, Pilar, Norman, Francesca, Crespillo, Clara, Pérez-Molina, José, Comeche, Belén, Chamorro, Sandra, Monge, Begoña, Moreno, Santiago, López-Vélez, Rogelio, Pérez-Elías, Maria Jesús, Fortún, Jesús, Navas, Enrique, Quereda, Carmen, Dronda, Fernando, Del Campo, Santos, Reinoso, Javier Cobo, Casado, José Luis, Moreno, Ana, Martín-Dávila, Pilar, Hermida, José Manuel, Pintado, Vicente, Serrano-Villar, Sergio, Sánchez-Conde, Matilde, Escudero, Rosa, Gioia, Francesca, Herrera, Sabina, Ron, Raquel, Martínez-Sanz, Javier, Pons-Guillén, Mario, Vivancos, María Jesús, Norman, Francesca F., Crespillo-Andújar, Clara, Pérez-Molina, José Antonio, Monge-Maillo, Begoña, and Moreno-Guillén, Santiago

Published
2021
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38. From Innovation to Implementation: The Evolution of HIV Pre-Exposure Prophylaxis and Future Implications.

Author

Rosas Cancio-Suárez, Marta, Díaz-Álvarez, Jorge, Ron, Raquel, Martínez-Sanz, Javier, Serrano-Villar, Sergio, Moreno, Santiago, and Sánchez-Conde, Matilde

Subjects
PRE-exposure prophylaxis, HIV, HIV infections, HIV infection transmission, SEXUAL intercourse, ANTIRETROVIRAL agents
Abstract

Pre-exposure prophylaxis (PrEP) is a highly effective HIV-prevention strategy that involves the continuous administration of antiretroviral drugs to HIV-negative individuals with a substantial risk of contracting an HIV infection. The use of PrEP has shown a reduction in the risk of HIV acquisition through sexual intercourse by up to 99%. Despite its effectiveness, PrEP uptake remains low among populations at high risk of HIV infection. This highlights the need for further research in strategies to enhance awareness and uptake of PrEP amongst these specific populations. This article presents a comprehensive overview of the existing literature on the effectiveness of PrEP in reducing HIV transmission rates. Additionally, we examine the obstacles related to PrEP implementation and uptake and put forward potential strategies to raise awareness and improve its use among populations at an increased risk of contracting HIV. [ABSTRACT FROM AUTHOR]

Published
2023
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39. Human Monkeypox in People With HIV: Transmission, Clinical Features, and Outcome

Author

Vivancos-Gallego, María Jesús, primary, Sánchez-Conde, Matilde, additional, Rodríguez-Domínguez, Mario, additional, Fernandez-Gonzalez, Pablo, additional, Martínez-García, Laura, additional, Garcia-Mouronte, Emilio, additional, Martínez-Sanz, Javier, additional, Moreno-Zamora, Ana María, additional, Casado, Jose Luis, additional, Ron, Raquel, additional, Galán, Juan Carlos, additional, Pérez-Elías, María Jesús, additional, and Moreno, Santiago, additional

Published
2022
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40. Metabolic-Related Outcomes After Switching From Tenofovir Disoproxil Fumarate to Tenofovir Alafenamide in Adults With Human Immunodeficiency Virus (HIV): A Multicenter Prospective Cohort Study

Author

Martínez-Sanz, Javier, primary, Serrano-Villar, Sergio, additional, Muriel, Alfonso, additional, García Fraile, Lucio J, additional, Orviz, Eva, additional, Mena de Cea, Álvaro, additional, Campins, Antoni A, additional, and Moreno, Santiago, additional

Published
2022
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41. The Negative Impact of COVID-19 in HCV, HIV, and HPV Surveillance Programs During the Different Pandemic Waves

Author

Romero-Hernández, Beatriz, primary, Martínez-García, Laura, additional, Rodríguez-Dominguez, Mario, additional, Martínez-Sanz, Javier, additional, Vélez-Díaz-Pallarés, Manuel, additional, Pérez Mies, Belen, additional, Muriel, A., additional, Gea, Francisco, additional, Pérez-Elías, María Jesús, additional, and Galán, Juan Carlos, additional

Published
2022
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42. Effects of HIV Infection in Plasma Free Fatty Acid Profiles among People with Non-Alcoholic Fatty Liver Disease

Author

Martínez-Sanz, Javier, primary, Calvo, María Visitación, additional, Serrano-Villar, Sergio, additional, Montes, María Luisa, additional, Martín-Mateos, Rosa, additional, Burgos-Santamaría, Diego, additional, Díaz-Álvarez, Jorge, additional, Talavera-Rodríguez, Alba, additional, Rosas, Marta, additional, Moreno, Santiago, additional, Fontecha, Javier, additional, and Sánchez-Conde, Matilde, additional

Published
2022
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43. CD4/CD8 Ratio During Human Immunodeficiency Virus Treatment: Time for Routine Monitoring?

Author

Ron, Raquel, Moreno, Elena, Martínez-Sanz, Javier, Brañas, Fátima, Sainz, Talía, Moreno, Santiago, and Serrano-Villar, Sergio

Subjects
HIV infections, ANTI-HIV agents, RNA virus infections, VIRAL load, TREATMENT effectiveness, PATIENT monitoring, CD4 lymphocyte count, IMMUNITY, DECISION making, T cells, ROUTINE diagnostic tests, PSYCHOLOGY of HIV-positive persons
Abstract

In the last decade, studies in persons with HIV (PWH) on antiretroviral therapy (ART) have shed light on the significance of persistently high CD8 counts and low CD4/CD8 ratios. A low CD4/CD8 ratio reflects increased immune activation and is associated with an increased risk of severe non-AIDS events. As a result, many clinicians now believe that the CD4/CD8 ratio can help in HIV monitoring, and many researchers now report it as an efficacy marker in interventional studies. However, the topic is more complex. Recent studies have not yielded unanimous conclusions on the ability of the CD4/CD8 ratio to predict adverse outcomes, and only some clinical guidelines recommend monitoring it. Knowledge gaps remain on the best cutoff points, associated clinical events, effects of treatments, and how the CD4/CD8 ratio could improve decision making in the clinic. Here, we critically review the literature, identify knowledge gaps, and discuss the role of the CD4/CD8 ratio as a marker for HIV monitoring. [ABSTRACT FROM AUTHOR]

Published
2023
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44. Similar CD4/CD8 Ratio Recovery After Initiation of Dolutegravir Plus Lamivudine Versus Dolutegravir or Bictegravir-Based Three-Drug Regimens in Naive Adults With HIV

Author

Universidad de Sevilla. Departamento de Medicina, Red Temática de Investigación Cooperativa en Sida, Instituto de Salud Carlos III, European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER), Martínez-Sanz, Javier, Ron, Raquel, Moreno, Elena, Sánchez-Conde, Matilde, Muriel, Alfonso, López Cortés, Luis Fernando, Pineda Vergara, Juan Antonio, Serrano-Villar, Sergio, Universidad de Sevilla. Departamento de Medicina, Red Temática de Investigación Cooperativa en Sida, Instituto de Salud Carlos III, European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER), Martínez-Sanz, Javier, Ron, Raquel, Moreno, Elena, Sánchez-Conde, Matilde, Muriel, Alfonso, López Cortés, Luis Fernando, Pineda Vergara, Juan Antonio, and Serrano-Villar, Sergio

Abstract

The initiation of antiretroviral treatment based on a 2-drug regimen (2DR) with dolutegravir plus lamivudine has demonstrated non-inferior efficacy than dolutegravir-based three-drug regimens (3DR). We aimed to assess whether the treatment initiation with this 2DR has a different impact on the CD4/CD8 ratio recovery than INSTI-based 3DR. Methods: We emulated a target trial using observational data from the Spanish HIV Research Network cohort (CoRIS). The outcomes of interest were the normalization of the CD4/CD8 ratio at 48 weeks using three different cutoffs: 0.5, 1.0, and 1.5. We matched each participant who started 2DR with up to four participants who received 3DR. Subsequently, we fitted generalized estimating equation (GEE) models and used the Kaplan–Meier method for survival curves. Results: We included 485, 805, and 924 participants for cutoffs of 0.5, 1.0, and 1.5, respectively. At 48 weeks, 45% of participants achieved a CD4/CD8 ratio >0.5, 15% achieved a ratio >1.0, and 6% achieved a ratio >1.5. GEE models yielded a similar risk of reaching a CD4/CD8 ratio >0.5 (OR 1.00, 95% CI 0.67 - 1.50), CD4/CD8 >1.0 (OR 1.03, 95% CI 0.68 - 1.58), and CD4/CD8 >1.5 (OR 0.86, 95% CI 0.48 - 1.54) between both treatment strategies. There were no differences between 2DR and 3DR in the incidence ratio of CD4/CD8 ratio normalization at 0.5, 1.0 and 1.5 cut-offs. Conclusions: In this large cohort study in people with HIV, ART initiation with dolutegravir plus lamivudine vs. dolutegravir or bictegravir-based triple antiretroviral therapy showed no difference in the rates of CD4/CD8 normalization at 48 weeks.

Published
2022

45. Effects of HIV infection in plasma free fatty acid profiles among people with non-alcoholic fatty liver disease

Author

Instituto de Salud Carlos III, European Commission, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Martínez-Sanz, Javier, Calvo, Maria V., Serrano-Villar, Sergio, Montes, María Luisa, Martín-Mateos, Rosa, Burgos-Santamaría, Diego, Díaz-Álvarez, Jorge, Talavera-Rodríguez, Alba, Rosas, Marta, Moreno, Santiago, Fontecha, F. Javier, Sánchez-Conde, Matilde, Instituto de Salud Carlos III, European Commission, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Martínez-Sanz, Javier, Calvo, Maria V., Serrano-Villar, Sergio, Montes, María Luisa, Martín-Mateos, Rosa, Burgos-Santamaría, Diego, Díaz-Álvarez, Jorge, Talavera-Rodríguez, Alba, Rosas, Marta, Moreno, Santiago, Fontecha, F. Javier, and Sánchez-Conde, Matilde

Abstract

Despite its high prevalence, the mechanisms underlying non-alcoholic fatty liver disease (NAFLD) in people living with HIV (PLWH) are still unclear. In this prospective cohort study, we aim to evaluate differences in plasma fatty acid profiles between HIV-infected and HIV-uninfected participants with NAFLD. We included participants diagnosed with NAFLD, both HIV-infected and HIV-uninfected. Fatty acid methyl esters were measured from plasma samples. Ratios ([product]/[substrate]) were used to estimate desaturases and elongases activity. We used linear regression for adjusted analyses. We included 31 PLWH and 22 HIV-uninfected controls. We did not find differences in the sum of different types of FA or in FA with a greater presence of plasma. However, there were significant differences in the distribution of some FA, with higher concentrations of ALA, trans-palmitoleic, and behenic acids, and a lower concentration of lignoceric acid in PLWH. PLWH had lower C24:0/C22:0 and C16:0/C14:0 ratios, which estimates the activity of elongases ELOVL1 and ELOVL6. Both groups had similar fatty acid distribution, despite differences in traditional risk factors. PLWH had a lower proportion of specific ratios that estimate ELOVL1 and ELOVL6 activity, which had been previously described for other inflammatory conditions, such as psoriasis.

Published
2022

46. An Easy-to-Implement Risk Score for Targeted Hepatitis C Virus Testing in the General Population

Author

Martínez-Sanz, Javier, primary, Vivancos-Gallego, María Jesús, additional, Fernández-Felix, Borja Manuel, additional, Muriel, Alfonso, additional, Pérez-Elías, Pilar, additional, Uranga, Almudena, additional, Romero, Beatriz, additional, Galán, Juan Carlos, additional, Moreno, Santiago, additional, and Pérez-Elías, María Jesús, additional

Published
2022
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47. Similar CD4/CD8 Ratio Recovery After Initiation of Dolutegravir Plus Lamivudine Versus Dolutegravir or Bictegravir-Based Three-Drug Regimens in Naive Adults With HIV

Author

Martínez-Sanz, Javier, Ron, Raquel, Moreno, Elena, Sánchez-Conde, Matilde, Muriel, Alfonso, López Cortés, Luis Fernando, Pineda Vergara, Juan Antonio, Serrano-Villar, Sergio, Universidad de Sevilla. Departamento de Medicina, Red Temática de Investigación Cooperativa en Sida, Instituto de Salud Carlos III, and European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER)

Subjects
Dual therapy, CD4/CD8 ratio, Integrase inhibitors, HIV, Antiretroviral therapy
Abstract

The initiation of antiretroviral treatment based on a 2-drug regimen (2DR) with dolutegravir plus lamivudine has demonstrated non-inferior efficacy than dolutegravir-based three-drug regimens (3DR). We aimed to assess whether the treatment initiation with this 2DR has a different impact on the CD4/CD8 ratio recovery than INSTI-based 3DR. Methods: We emulated a target trial using observational data from the Spanish HIV Research Network cohort (CoRIS). The outcomes of interest were the normalization of the CD4/CD8 ratio at 48 weeks using three different cutoffs: 0.5, 1.0, and 1.5. We matched each participant who started 2DR with up to four participants who received 3DR. Subsequently, we fitted generalized estimating equation (GEE) models and used the Kaplan–Meier method for survival curves. Results: We included 485, 805, and 924 participants for cutoffs of 0.5, 1.0, and 1.5, respectively. At 48 weeks, 45% of participants achieved a CD4/CD8 ratio >0.5, 15% achieved a ratio >1.0, and 6% achieved a ratio >1.5. GEE models yielded a similar risk of reaching a CD4/CD8 ratio >0.5 (OR 1.00, 95% CI 0.67 - 1.50), CD4/CD8 >1.0 (OR 1.03, 95% CI 0.68 - 1.58), and CD4/CD8 >1.5 (OR 0.86, 95% CI 0.48 - 1.54) between both treatment strategies. There were no differences between 2DR and 3DR in the incidence ratio of CD4/CD8 ratio normalization at 0.5, 1.0 and 1.5 cut-offs. Conclusions: In this large cohort study in people with HIV, ART initiation with dolutegravir plus lamivudine vs. dolutegravir or bictegravir-based triple antiretroviral therapy showed no difference in the rates of CD4/CD8 normalization at 48 weeks.

Published
2022

48. Long-Term Changes of Inflammatory Biomarkers in Individuals on Suppressive Three-Drug or Two-Drug Antiretroviral Regimens

Author

Serrano-Villar, Sergio, Lopez-Huertas, Maria Rosa, Jiménez, Daniel, Galera, Carlos, Martínez-Sanz, Javier, Moreno, Elena, Muriel, Alfonso, Gutiérrez, Félix, Busca, Carmen, Portilla, Joaquín, Bisbal, Otilia, Iribarren, José Antonio, Tejerina, Francisco, de los Santos, Ignacio, Moreno, Santiago, CoRIS Cohort, Instituto de Salud Carlos III, Ministerio de Sanidad (España), Plan de Recuperación, Transformación y Resiliencia (España), Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF), Red de Investigación Cooperativa en Investigación en Sida, Centro de Investigación Biomédica en Red - CIBERINFEC (Enfermedades Infecciosas), and Gilead Sciences (Spain)

Subjects
Inflammation, C reactive protein, Anti-HIV Agents, Immunology, HIV, HIV Infections, Antiretroviral therapy, C-Reactive Protein, Anti-Retroviral Agents, Lamivudine, D-dimer, Humans, Immunology and Allergy, Biomarkers
Abstract

Background: Because inflammation is associated with mortality and has been linked to HIV transcription in lymphoid tissues during ART, it is necessary to address the long-term effects of switching 3-drug (3DR) to 2-drug regimens (2DR) on inflammation. Methods: Nested study in the Spanish AIDS Research Network. We selected PWH ART-naive initiating 3DR who achieved viral suppression in the first 48 weeks and either remained on 3DR or switched to 2DR (3TC+bPI; 3TC+DTG; DTG+RPV). We assessed the trajectories on inflammatory markers during ART using multivariate piecewise mixed models. Results: We analyzed 619 plasma samples from 148 patients (3DR, N=90; 2DR, N=58), the median follow-up was 4.6 (IQR 3.2-6.2) years. There were no significant differences in baseline characteristics between groups. After adjusting for potential confounders, patients with 3DR experienced a slow decline of IL6, hs-CRP, sCD14, sCD163, and D-dimer over time. In contrast, compared to 3DR, switching to 2DR was associated with increases in IL-6 (p=0.001), hs-CRP (p=0.003), and D-dimer (p=0.001) after year 3 from virologic suppression. 2DR was associated with a higher risk of hs-CRP quartile increase (aOR 3.3, 95%CI 1.1-10) and D-dimer quartile increase (aOR 3.7, 95%CI 1.1-13). The adjusted biomarker trajectories did not reveal a distinct pattern according to the type of 2DR used (bPI vs DTG). Conclusions: In this study in virally suppressed individuals, maintaining 3DR was associated with a more favorable long-term inflammatory profile than switching to 2DR. The potential clinical implications of these findings on the development of non-AIDS events deserve further investigation. The HIV BioBank, integrated in the Spanish AIDS Research Network, is supported by Instituto de Salud Carlos III, Spanish Health Ministry (Grant n° proyectos RD06/0006/0035, RD12/0017/0037 and RD16/0025/0019) as part of the Plan Nacional R + D + I and co-financed by the European Development Regional Fund ‘‘A way to achieve Europe’’ (ERDF). The RIS Cohort (CoRIS) is funded by the Instituto de Salud Carlos III through the Red Temática de Investigación Cooperativa en SIDA (RIS C03/173, RD12/0017/0018 and RD16/0002/0006) as part of the Plan Nacional R+D+I and cofinanced by ISCIII-Subdirección General de Evaluacion and Fondo Europeo de Desarrollo Regional (FEDER)”. This work was supported by the Instituto de Salud Carlos III projects AC17/00019, PI18/00154, ICI20/00058, CIBER de Enfermedades Infecciosas, and Gilead Sciences (Investigator Sponsored Research ISR-17-10192). The funders had no role in the study design, data analysis, or in the interpretation of the results. Sí

Published
2022

49. Metabolic-Related Outcomes After Switching From Tenofovir Disoproxil Fumarate to Tenofovir Alafenamide in Adults With Human Immunodeficiency Virus (HIV): A Multicenter Prospective Cohort Study.

Author

Martínez-Sanz, Javier, Serrano-Villar, Sergio, Muriel, Alfonso, Fraile, Lucio J García, Orviz, Eva, Cea, Álvaro Mena de, Campins, Antoni A, and Moreno, Santiago

Subjects
*HYPERTENSION epidemiology, *HIV infections, *HIV-positive persons, *RESEARCH, *HDL cholesterol, *LIPOPROTEINS, *TRIGLYCERIDES, *GENERIC drug substitution, *ANTILIPEMIC agents, *TENOFOVIR, *ANTIRETROVIRAL agents, *DIABETES, *TREATMENT effectiveness, *METABOLIC disorders, *RISK assessment, *WEIGHT gain, *DESCRIPTIVE statistics, *RESEARCH funding, *LONGITUDINAL method, *CHOLESTEROL, *DISEASE risk factors, *ADULTS
Abstract

Background Tenofovir alafenamide (TAF) has replaced tenofovir disoproxil fumarate (TDF) in many clinical settings. However, concerns remain about potential metabolic complications of TAF. We aimed to evaluate changes in weight, laboratory markers, and metabolic-related clinical events after replacing TDF with TAF. Methods Multicenter prospective cohort study in the Spanish CoRIS cohort. We included virologically suppressed adults with human immunodeficiency virus (HIV) receiving TDF for more than 12 months who either switched to TAF or maintained TDF, with no changes in the core agent. Participants were matched by propensity score. We fitted generalized equation models to assess changes in weight, blood lipids, and hepatic steatosis index, and to compare the incidence of diabetes, hypertension, and lipid-lowering drug use after 144 weeks. Results In total, 1446 participants were matched in each group. Median age was 38 years, 85% were male, mean weight at baseline was 73 kg. Participants who switched to TAF had a mean weight increase of +0.5 kg at 144 weeks over those who maintained TDF, with no difference in the occurrence of overweight or obesity. Individuals who switched to TAF had a significant increase in total cholesterol (+7.9 mg/dL) and triglycerides (+11.2 mg/dL), with no differences in the total cholesterol-high-density lipoprotein (HDL) ratio. However, no increased incidence of diabetes, hypertension, or lipid-lowering drug use was observed after the follow-up period. Conclusions Switching from TDF to TAF is associated with modest weight gain and increases in total cholesterol and triglycerides, without an impact on the incidence of obesity or metabolic-related clinical events, in this Spanish cohort with a majority White male population. [ABSTRACT FROM AUTHOR]

Published
2023
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50. Similar CD4/CD8 Ratio Recovery After Initiation of Dolutegravir Plus Lamivudine Versus Dolutegravir or Bictegravir-Based Three-Drug Regimens in Naive Adults With HIV

Author

Martínez-Sanz, Javier, primary, Ron, Raquel, additional, Moreno, Elena, additional, Sánchez-Conde, Matilde, additional, Muriel, Alfonso, additional, López Cortés, Luis Fernando, additional, Blanco, José Ramón, additional, Pineda, Juan Antonio, additional, Mena, Álvaro, additional, Calzado Isbert, Sonia, additional, Moreno, Santiago, additional, and Serrano-Villar, Sergio, additional

Published
2022
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