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392 results on '"Martínez-Mir, A."'

8. Fluticasone in mild to moderate atopic dermatitis relapse: A randomized controlled trial

Author

Rubio-Gomis, E., Martinez-Mir, I., Morales-Olivas, F.J., Martorell-Aragones, A., Palop-Larrea, V., Bernalte-Sesé, A., Cerda-Mir, J.C., Polo-Martín, P., Febrer, I., Aranda-Grau, L., Llosa-Cortes, I., Tejedor-Sanz, Mª.J., Julia-Benito, J.C., Alvarez-de-Laviada-Mulero, T., Planelles-Cantarino, Mª.V., Apolinar-Valiente, E., Loriente-Tur, M., Abella-Bazataqui, A.M., Alvarez-Gonzalez, I., Morales-Carpi, C., Burches-Greus, Mª.E., Ferrer-Bautista, A.B., Felix-Toledo, R., Marmaneu-Laguia, D., Garcia-Martinez, V.E., Beltran-Marques, Mª.A., and Rodriguez-Gracia, B.

Published
2018
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10. A Neuroligin-1 mutation associated with Alzheimer’s disease produces memory and age-dependent impairments in hippocampal plasticity

Author

Universidad de Sevilla. Departamento de Fisiología Médica y Biofísica, European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER), Junta de Andalucía, Ministerio de Ciencia, Innovación y Universidades (MICINN). España, Ministerio de Economia, Industria y Competitividad (MINECO). España, Formación de Profesorado Universitario predoctoral fellowship del Ministerio de Universidades, Arias-Aragón, Francisco, Tristán Clavijo, Enriqueta, Martínez Gallego, Irene, Robles Lanuza, Estefanía, Coatl-Cuaya, Heriberto, Martín-Cuevas, Celia, Sánchez Hidalgo, Ana Carmen, Rodríguez Moreno, Antonio, Martínez Mir, Amalia, Gómez Scholl, Francisco Manuel, Universidad de Sevilla. Departamento de Fisiología Médica y Biofísica, European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER), Junta de Andalucía, Ministerio de Ciencia, Innovación y Universidades (MICINN). España, Ministerio de Economia, Industria y Competitividad (MINECO). España, Formación de Profesorado Universitario predoctoral fellowship del Ministerio de Universidades, Arias-Aragón, Francisco, Tristán Clavijo, Enriqueta, Martínez Gallego, Irene, Robles Lanuza, Estefanía, Coatl-Cuaya, Heriberto, Martín-Cuevas, Celia, Sánchez Hidalgo, Ana Carmen, Rodríguez Moreno, Antonio, Martínez Mir, Amalia, and Gómez Scholl, Francisco Manuel

Abstract

Alzheimer’s disease (AD) is characterized by memory impairments and age-dependent synapse loss. Experimental and clinical studies have shown decreased expression of the glutamatergic protein Neuroligin-1 (Nlgn1) in AD. However, the consequences of a sustained reduction of Nlgn1 are unknown. Here, we generated a knockin mouse that reproduces the NLGN1 Thr271fs mutation, identified in heterozygosis in a familial case of AD. We found that Nlgn1 Thr271fs mutation abolishes Nlgn1 expression in mouse brain. Importantly, heterozygous Nlgn1 Thr271fs mice showed delay-dependent amnesia for recognition memory. Electrophysiological recordings uncovered age-dependent impairments in basal synaptic transmission and long-term potentiation (LTP) in CA1 hippocampal neurons of heterozygous Nlgn1 Thr271fs mice. In contrast, homozygous Nlgn1 Thr271fs mice showed impaired fear-conditioning memory and normal basal synaptic transmission, suggesting unshared mechanisms for a partial or total loss of Nlgn1. These data suggest that decreased Nlgn1 may contribute to the synaptic and memory deficits in AD.

Published
2023

12. Supplemental information. A Neuroligin-1 mutation associated with Alzheimer’s disease produces memory and age-dependent impairments in hippocampal plasticity

Author

Arias-Aragón, Francisco, Tristán Clavijo, E., Martínez-Gallego, Irene, Robles Lanuza, Estefanía, Coatl-Cuaya, Heriberto, Martín-Cuevas, Celia, Sánchez-Hidalgo, Ana C., Rodríguez-Moreno, Antonio, Martínez Mir, Amalia, Scholl, Francisco G., Arias-Aragón, Francisco, Tristán Clavijo, E., Martínez-Gallego, Irene, Robles Lanuza, Estefanía, Coatl-Cuaya, Heriberto, Martín-Cuevas, Celia, Sánchez-Hidalgo, Ana C., Rodríguez-Moreno, Antonio, Martínez Mir, Amalia, and Scholl, Francisco G.

Published
2023

13. A Neuroligin-1 mutation associated with Alzheimer's disease produces memory and age-dependent impairments in hippocampal plasticity

Author

Ministerio de Ciencia, Innovación y Universidades (España), Junta de Andalucía, Ministerio de Economía y Competitividad (España), Agencia Estatal de Investigación (España), European Commission, Universidad de Sevilla, Arias-Aragón, Francisco, Tristán Clavijo, E., Martínez-Gallego, Irene, Robles Lanuza, Estefanía, Coatl-Cuaya, Heriberto, Martín-Cuevas, Celia, Sánchez-Hidalgo, Ana C., Rodríguez-Moreno, Antonio, Martínez Mir, Amalia, Scholl, Francisco G., Ministerio de Ciencia, Innovación y Universidades (España), Junta de Andalucía, Ministerio de Economía y Competitividad (España), Agencia Estatal de Investigación (España), European Commission, Universidad de Sevilla, Arias-Aragón, Francisco, Tristán Clavijo, E., Martínez-Gallego, Irene, Robles Lanuza, Estefanía, Coatl-Cuaya, Heriberto, Martín-Cuevas, Celia, Sánchez-Hidalgo, Ana C., Rodríguez-Moreno, Antonio, Martínez Mir, Amalia, and Scholl, Francisco G.

Abstract

Alzheimer's disease (AD) is characterized by memory impairments and age-dependent synapse loss. Experimental and clinical studies have shown decreased expression of the glutamatergic protein Neuroligin-1 (Nlgn1) in AD. However, the consequences of a sustained reduction of Nlgn1 are unknown. Here, we generated a knockin mouse that reproduces the NLGN1 Thr271fs mutation, identified in heterozygosis in a familial case of AD. We found that Nlgn1 Thr271fs mutation abolishes Nlgn1 expression in mouse brain. Importantly, heterozygous Nlgn1 Thr271fs mice showed delay-dependent amnesia for recognition memory. Electrophysiological recordings uncovered age-dependent impairments in basal synaptic transmission and long-term potentiation (LTP) in CA1 hippocampal neurons of heterozygous Nlgn1 Thr271fs mice. In contrast, homozygous Nlgn1 Thr271fs mice showed impaired fear-conditioning memory and normal basal synaptic transmission, suggesting unshared mechanisms for a partial or total loss of Nlgn1. These data suggest that decreased Nlgn1 may contribute to the synaptic and memory deficits in AD.

Published
2023

15. Translational study of obesity management using the Diabetes Prevention Program 'Group Lifestyle Balance' in primary care clinics and public hospitals from Mexico: study protocol

Author

Rolando Giovanni Díaz-Zavala, Brianda Ioanna Armenta-Guirado, Teresita de Jesús Martínez-Contreras, Maria del Carmen Candia-Plata, Julián Esparza-Romero, Raúl Martínez-Mir, Michelle M. Haby, and Mauro E. Valencia

Subjects
Diabetes Prevention Program, Translational Medical Research, Weight Loss, Obesity, Life Style, Health Knowledge, Nutrition. Foods and food supply, TX341-641, Nutritional diseases. Deficiency diseases, RC620-627
Abstract

Introduction: Obesity is the main modifiable risk factor for the development of chronic diseases in Mexico. Several randomized controlled trials have shown that intensive lifestyle programs are efficacious for the management of obesity. These programs include frequent sessions (14 or more contacts in the first 6 months) focused on diet and physical activity and use a behavior change protocol. However, most Mexican primary care clinics and public hospitals apply traditional treatments for obesity management with limited results on weight loss. The purpose of the study is to evaluate the effectiveness of the Diabetes Prevention Program (DPP) “Group Lifestyle Balance” for weight loss among adults with overweight and obesity from baseline to 6 months and from baseline to 12 months in primary care clinics and public hospitals from Sonora, Mexico. Material and Methods: This is a translational, multi-center, non-controlled, 6 and 12-month follow-up clinical study with a pre-test and post-test design. Healthcare providers from two primary care clinics, two hospitals and one university clinic will be trained with the DPP protocol to implement on their patients with overweight and obesity. Body weight, body mass index, waist circumference, systolic and diastolic blood pressure, depression, quality of life and stress scales will be measured in participants receiving the program at baseline, 6 and 12 months. Biochemical parameters will be measured at baseline and 12 months. The primary outcome is the change in body weight at 6 and 12 months. Discussion: This study will provide scientific evidence of the effectiveness of the DPP protocol as a model for obesity management in real world clinical practice among the adult Mexican population.

Published
2017
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16. Efectos del masaje terapéutico recíproco sobre la limitación del movimiento del raquis cervical y el apoyo social en el adulto mayor y su cuidador familiar

Author

Reyes Figueroa Martínez, Ena Monserrat Romero Pérez, Raúl Martínez Mir, Gabriel Nuñez Othon, Mario Alberto Horta Gim, and José Antonio De Paz Fernández

Abstract

El cuidador familiar (CF) facilita la extensión al hogar de los servicios de salud para el creciente número de adultos mayores (AM). El objetivo del trabajo fue evaluar los efectos de una intervención de masaje terapéutico (MT) aplicado recíprocamente entre AM y CF, para medir cambios en la limitación del movimiento cervical y la percepción de apoyo recibido de parte de cada integrante de la pareja. Al término de la intervención se identificó un aumento significativo en el arco de movimiento del raquis cervical en el AM y CF al comparar las puntuaciones pre-post, sugiriéndose que el MT puede revertir la limitación de movilidad cervical en proveedor y receptor de cuidados, así como favorecer la percepción de apoyo mutuo.

Published
2022
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21. Selective expression of the neurexin substrate for presenilin in the adult forebrain causes deficits in associative memory and presynaptic plasticity

Author

Ministerio de Ciencia, Innovación y Universidades (España), Junta de Andalucía, European Commission, Ministerio de Economía, Industria y Competitividad (España), Universidad de Sevilla, Sánchez-Hidalgo, Ana C., Arias-Aragón, Francisco, Romero-Barragán, M. Teresa, Martín-Cuevas, Celia, Delgado-García, José M., Martínez Mir, Amalia, Ministerio de Ciencia, Innovación y Universidades (España), Junta de Andalucía, European Commission, Ministerio de Economía, Industria y Competitividad (España), Universidad de Sevilla, Sánchez-Hidalgo, Ana C., Arias-Aragón, Francisco, Romero-Barragán, M. Teresa, Martín-Cuevas, Celia, Delgado-García, José M., and Martínez Mir, Amalia

Abstract

Presenilins (PS) form the active subunit of the gamma-secretase complex, which mediates the proteolytic clearance of a broad variety of type-I plasma membrane proteins. Loss-of-function mutations in PSEN1/2 genes are the leading cause of familial Alzheimer's disease (fAD). However, the PS/gamma-secretase substrates relevant for the neuronal deficits associated with a loss of PS function are not completely known. The members of the neurexin (Nrxn) family of presynaptic plasma membrane proteins are candidates to mediate aspects of the synaptic and memory deficits associated with a loss of PS function. Previous work has shown that fAD-linked PS mutants or inactivation of PS by genetic and pharmacological approaches failed to clear Nrxn C-terminal fragments (NrxnCTF), leading to its abnormal accumulation at presynaptic terminals. Here, we generated transgenic mice that selectively recreate the presynaptic accumulation of NrxnCTF in adult forebrain neurons, leaving unaltered the function of PS/gamma-secretase complex towards other substrates. Behavioral characterization identified selective impairments in NrxnCTF mice, including decreased fear-conditioning memory. Electrophysiological recordings in medial prefrontal cortex-basolateral amygdala (mPFC-BLA) of behaving mice showed normal synaptic transmission and uncovered specific defects in synaptic facilitation. These data functionally link the accumulation of NrxnCTF with defects in associative memory and short-term synaptic plasticity, pointing at impaired clearance of NrxnCTF as a new mediator in AD.

Published
2022

23. Gender influence in the quantity of drugs used in primary care Influencia del género en la cantidad de los medicamentos utilizados en atención primaria

Author

José Sanfélix, Vicente Palop, Inmaculada Pereiró, Elena Rubio, Victoria Gosalbes, and Inocencia Martínez-Mir

Subjects
Diferencias de género, Medicamentos, Problemas de salud, Estudio transversal, Atención primaria, Gender differences, Drugs, Health problems, Cross-sectional study, Primary care, Public aspects of medicine, RA1-1270
Abstract

Objective: To analyze whether for an equal health problem there are gender differences in the drugs used in an adult population attended in the Health Care Centers of the Valencian Community (Spain). Methods: A cross-sectional analytical study was carried out between February-August 1997. The independent variables were: socio-economic parameters, frequency of visits, and self-perceived or diagnosed health problems, and the dependent one the number of drugs consumed. Results: Of the 812 patients considered, 801 consumed medication. Eighty percent of the health problems for which drugs were used involved 5 apparatuses and systems (mean: 3.3 health problems/patient). The 5 most consumed therapeutic groups accounted for 81% of the total (mean: 4.5 drugs/patient). Significant differences were recorded, with greater female consumption in the central nervous system and genitourinary tract therapeutic groups, and with greater male consumption in relation to the respiratory system and systemic anti-infectious therapy. Drug use increased with age, lowest educational level, lowest professional categories, and with the highest frequency of visits to the physician. Significant differences were also recorded in drug use by occupational status, marital status and family structure. The multivariate analysis showed the number of health problems and the frequency of visits accounted for 82.2% of the variability of the variable «number of drugs consumed». The variability accounted for by gender was explained by the variable health problems, the main factor underlying drug consumption among women and men. Conclusion: The main finding is probably that women do not use larger numbers of drugs than men if health problems and frequency of visits are controlled.Objetivo: Analizar si para el mismo problema de salud hay diferencias de género en los medicamentos utilizados en una población adulta atendida en centros de salud de la Comunidad Valenciana. Métodos: Estudio observacional transversal analítico realizado entre febrero y agosto de 1997. Variables independientes: parámetros socioeconómicos, frecuentación de los servicios de salud y problemas de salud autopercibidos o diagnosticados. Variable independiente: número de medicamentos consumidos. Resultados: De los 812 pacientes, 801 tomaban medicamentos. El 80% de los problemas de salud por los que se medicaban pertenece a 5 aparatos y sistemas (media: 3,3 problemas de salud por paciente). Los 5 grupos terapéuticos más consumidos suponen el 81% del total (media: 4,5 medicamentos por paciente). Se evidenció un mayor consumo significativo por la mujer de medicamentos de los grupos terapéuticos del sistema nervioso central e infecciones genitourinarias, y mayor consumo por los varones de medicamentos de los grupos terapéuticos del sistema respiratorio y terapia antiinfecciosa sistémica. El uso de los medicamentos incrementó con la edad, el menor nivel educativo, menor categoría profesional y con la mayor frecuencia de visitas. También se encontraron diferencias significativas en el uso de medicamentos según la situación laboral, estado marital y la estructura familiar. El análisis multivariante mostró que el número de problemas de salud y la frecuencia de visitas explicaban el 82,2% de la variabilidad de la variable «número de medicamentos consumidos». La variabilidad representada por el género se explicó por la variable de problemas de salud, el principal factor subyacente del consumo de medicamentos entre mujeres y hombres. Conclusiones: El hallazgo principal es, probablemente, que las mujeres no utilizan mayor número de medicamentos que los hombres al ajustar por problemas de salud y la frecuencia de las visitas.

Published
2008

26. Adecuación de la seguridad del metamizol y agranulocitosis

Author

Cristina Garcia del Campo, Vicente Palop Larrea, Inocencia Martínez-Mir, and Miguel Murcia Soler

Subjects
Metamizole, Medicine (General), Databases, Factual, Original, Anti-Inflammatory Agents, Non-Steroidal, Metamizol, Dipyrone, Drug safety update, General Medicine, 030226 pharmacology & pharmacy, 03 medical and health sciences, 0302 clinical medicine, R5-920, Spain, Nota informativa, Humans, 030212 general & internal medicine, Agranulocitosis, Safety, Family Practice, Seguridad, Agranulocytosis
Abstract

Resumen: Objetivo: Analizar si la nota informativa de la Agencia Española de Medicamentos y Productos Sanitarios (AEMPS), de 30 de octubre del 2018, sobre agranulocitosis y metamizol contiene la información precisa y necesaria para proteger a los pacientes de la aparición de esta reacción adversa (RA) y si la documentación oficial de los medicamentos con metamizol para médicos, farmacéuticos y población general está adaptada a las directrices de la AEMPS para disminuir el riesgo. Emplazamiento y participantes: Nota informativa, búsqueda bibliográfica, información sobre los medicamentos con metamizol comercializados en España en la Agencia Europea del Medicamento, fichas técnicas, prospectos, base de datos de información sanitaria Bot PLUS y Catálogo de Especialidades Farmacéuticas. Notificación de 4 casos de agranulocitosis por metamizol posteriores a la fecha de la nota informativa. Intervenciones y mediciones principales: Comparación de los puntos clave de la nota informativa y de los documentos oficiales sobre metamizol con la bibliografía. Descripción de 4 casos de agranulocitosis por metamizol y aplicación del algoritmo de causalidad y gravedad. Resultados: La nota informativa presenta ausencias y dudas respecto a la bibliografía y al uso de metamizol en la práctica asistencial. Los documentos oficiales presentan faltas de actualización, indicaciones no aprobadas y dosis superiores a las recomendadas. La nota informativa no ha frenado la presentación de casos de agranulocitosis por metamizol. Conclusiones: La nota informativa de la AEMPS es mejorable y es necesario actualizar los documentos oficiales de información sobre el metamizol para profesionales sanitarios y pacientes para disminuir el riesgo de agranulocitosis. Abstract: Objective: To analyze whether the drug safety update issued by the Spanish Agency of Medicines and Healthcare Products (AEMPS), dated October 30, 2018, on agranulocytosis and metamizole contains accurate and necessary information to protect patients from the presentation of this adverse reaction (AR) and if the official documentation of medicines containing metamizole for doctors, pharmacists and the general population conforms to the guidelines of the AEMPS to reduce this risk. Setting and participants: Drug safety update, bibliographic search, information at the European Medicines Agency on metamizole drugs marketed in Spain, technical datasheets, leaflets, Bot PLUS Health Information Database and Catalog of Pharmaceutical Specialties. Notification of 4 cases of agranulocytosis due to metamizole after the drug safety update was issued. Main interventions and measurements: Comparison of the key points of the drug safety update and official documents on metamizole with the bibliography. Description of the 4 cases of agranulocytosis due to metamizole and application of the causality and severity algorithm. Results: The drug safety update contains omissions and contradiction in respect to the bibliography and the actual use of metamizole in healthcare practice. The official documents show a lack of updating, unapproved indications and doses higher than those recommended. The drug safety update has not stopped the presentation of cases of agranulocytosis due to metamizole. Conclusions: The AEMPS drug safety update can be improved and it is necessary to update the official information documents on metamizole for health professionals and patients in order to decrease the risk of agranulocytosis.

Published
2021

31. Modelo de actuación para las/los psicólogas/os que intervienen como peritos en delitos sexuales y violencia familiar

Author

Marco Antonio Gutiérrez Landavazo, Adelina Fuentes Ornelas, Héctor Guillermo Campbell Araujo, María Luisa Esquer Castro, José Rodrigo Abril López, Mayra Cecilia Arriola Álvarez, Luis Enrique Fierros Dávila, Danitza Dayanara Chaires Borboa, Raúl Martínez Mir, Martín de Jesús Jiménez Flores, Roberto Corral Valencia, Miguel Espinoza de Santiago, Miguel Armando Gutiérrez Dávila, and Francisco Javier Marrujo Castillo

Abstract

La presente obra responde a la necesidad de sustentar legal y científicamente los estudios, dictámenes o informes del área de psicología en el ámbito foren¬se de los casos de violencia familiar y delitos sexuales en cualquiera de sus modalidades. Su finalidad es ofrecer procesos, procedimientos y directrices generales para apoyar a los profesionales en psicología que realicen intervenciones en esta materia, facilitar la evaluación de los daños y la elaboración del informe pericial o dictamen. Las pautas de recomendación presentadas podrán ser aplicadas en personas de diferente edad, sexo, condición social, personas vulnerables e incluso de diversas nacionalidades, y ser consideradas como una directriz en un sentido de transparencia.

Published
2021
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32. Revealing the spatio-phenotypic patterning of cells in healthy and tumor tissues with mLSR-3D and STAPL-3D

Author

Ravian L, van Ineveld, Michiel, Kleinnijenhuis, Maria, Alieva, Sam, de Blank, Mario, Barrera Roman, Esmée J, van Vliet, Clara, Martínez Mir, Hannah R, Johnson, Frank L, Bos, Raimond, Heukers, Susana M, Chuva de Sousa Lopes, Jarno, Drost, Johanna F, Dekkers, Ellen J, Wehrens, and Anne C, Rios

Subjects
Deep Learning, Imaging, Three-Dimensional, Phenotype, Neoplasms, Biomarkers, Tumor, Image Processing, Computer-Assisted, Humans, Kidney, Software, Fluorescent Dyes
Abstract

Despite advances in three-dimensional (3D) imaging, it remains challenging to profile all the cells within a large 3D tissue, including the morphology and organization of the many cell types present. Here, we introduce eight-color, multispectral, large-scale single-cell resolution 3D (mLSR-3D) imaging and image analysis software for the parallelized, deep learning-based segmentation of large numbers of single cells in tissues, called segmentation analysis by parallelization of 3D datasets (STAPL-3D). Applying the method to pediatric Wilms tumor, we extract molecular, spatial and morphological features of millions of cells and reconstruct the tumor's spatio-phenotypic patterning. In situ population profiling and pseudotime ordering reveals a highly disorganized spatial pattern in Wilms tumor compared to healthy fetal kidney, yet cellular profiles closely resembling human fetal kidney cells could be observed. In addition, we identify previously unreported tumor-specific populations, uniquely characterized by their spatial embedding or morphological attributes. Our results demonstrate the use of combining mLSR-3D and STAPL-3D to generate a comprehensive cellular map of human tumors.

Published
2020

40. Modelo de actuación para las/los psicólogas/os que intervienen como peritos en delitos sexuales y violencia familiar

Author

Gutiérrez Landavazo, Marco Antonio, primary, Fuentes Ornelas, Adelina, additional, Campbell Araujo, Héctor Guillermo, additional, Esquer Castro, María Luisa, additional, Abril López, José Rodrigo, additional, Arriola Álvarez, Mayra Cecilia, additional, Fierros Dávila, Luis Enrique, additional, Chaires Borboa, Danitza Dayanara, additional, Martínez Mir, Raúl, additional, Jiménez Flores, Martín de Jesús, additional, Corral Valencia, Roberto, additional, Espinoza de Santiago, Miguel, additional, Gutiérrez Dávila, Miguel Armando, additional, and Marrujo Castillo, Francisco Javier, additional

Published
2021
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43. Germline fumarate hydratase mutations and evidence for a founder mutation underlying multiple cutaneous and uterine leiomyomata

Author

Chuang, Gary S., Martinez-Mir, Amalia, Geyer, Adam, Engler, Danielle E., Glaser, Benjamin, Cserhalmi-Friedman, Peter B., Gordon, Derek, Horev, Liran, Lukash, Barbara, Herman, Eric, Cid, Manuel Prieto, Brenner, Sarah, Landau, Marina, Sprecher, Eli, Garcia Muret, Maria Pilar, Christiano, Angela M., and Zlotogorski, Abraham

Published
2005
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45. Effectiveness of the Diabetes Prevention Program for Obesity Treatment in Real World Clinical Practice in a Middle-Income Country in Latin America

Author

Rolando Giovanni Díaz-Zavala, Teresita Martínez-Contreras, Raúl Martínez-Mir, Mauro E. Valencia, Maria del Carmen Candia-Plata, Brianda Ioanna Armenta-Guirado, Julián Esparza-Romero, and Michelle M. Haby

Subjects
Adult, Counseling, Male, Program evaluation, Time Factors, Health Status, effectiveness, diabetes prevention, 030209 endocrinology & metabolism, lcsh:TX341-641, Type 2 diabetes, Article, Management of obesity, 03 medical and health sciences, 0302 clinical medicine, Patient Education as Topic, Risk Factors, Weight loss, Diabetes mellitus, medicine, Humans, Healthy Lifestyle, Obesity, 030212 general & internal medicine, Exercise, obesity treatment, lifestyle interventions, mexico, Nutrition and Dietetics, business.industry, latin america, Middle Aged, medicine.disease, Treatment Outcome, Diabetes Mellitus, Type 2, Female, Diet, Healthy, medicine.symptom, weight loss, business, Risk Reduction Behavior, Nutrition counseling, Body mass index, lcsh:Nutrition. Foods and food supply, Program Evaluation, Food Science, Demography
Abstract

The Diabetes Prevention Program (DPP) is effective for the prevention of type 2 diabetes by weight loss with diet and physical activity. However, there is little evidence as to whether this program could be translated into real-world clinical practice in Latin American countries. The objective of this work was to evaluate the effectiveness of the DPP for the management of overweightness and obesity at 6 and 12 months in clinical practice in Mexico. This was a non-controlled intervention study implemented in five public clinics in northern Mexico. Two hundred and thirty-seven adults aged 45.7 &plusmn, 9.9 years with a Body Mass Index (BMI) of 34.4 &plusmn, 5.4 kg/m2 received group sessions with an adaptation of the DPP, in addition to nutrition counseling. One hundred and thirty-three (56%) participants concluded the 6 month phase. They showed a significant weight loss, ranging from 2.76 &plusmn, 4.76 to 7.92 &plusmn, 6.85 kg (p &le, 0.01) in the clinics. The intention-to-treat analysis showed a more conservative weight loss. Participant retention at the end of 12 months was low (40%). The implementation of the DPP in different public clinics in Mexico was effective in the management of obesity in the short term, but better strategies are required to improve participant retention in the long term.

Published
2019

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