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Your search keyword '"Martínez-López, A.L."' showing total 14 results
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14 results on '"Martínez-López, A.L."'

3. List of contributors

Author

Abo Dena, Ahmed S., primary, Acquah, Caleb, additional, Ahmed, Tanvir, additional, Ajit, Azilah, additional, Al-Awthan, Yahya S., additional, Albuquerque, Tânia, additional, Anil, Sukumaran, additional, Apolonio–Hernandez, Nuvia Marina, additional, Atanase, Leonard Ionut, additional, Bahattab, Omar, additional, Behera, Anindita, additional, Bilal, Muhammad, additional, Bugarski, Branko, additional, Campa-Mada, A.C., additional, Carbajal-Valenzuela, Ireri Alejandra, additional, Carvajal-Millan, E., additional, Chen, Long, additional, Cheng, Wai Teng, additional, Colmenarez Lobo, Custodiana A., additional, Costa, Diana, additional, Costa, Eduardo, additional, Dalavi, Pandurang Appana, additional, Danquah, Michael K., additional, De Anda-Flores, Y., additional, Deshmukh, Harshal, additional, Dhara, Amal Kumar, additional, El-Sherbiny, Ibrahim M., additional, Faria, Rúben, additional, Feregrino-Pérez, Ana Angelica, additional, Figueroa-Pizano, M.D., additional, Gamage, D.A.S., additional, González-Arias, Beatriz, additional, Govindan, Natanamurugaraj, additional, Guevara-González, Ramón Gerardo, additional, Gutierrez-Chavez, Diana Vanesa, additional, Hasnain, Md Saquib, additional, Hossain, Shafiul, additional, Imran, Muhammad, additional, Iqbal, Hafiz M.N., additional, Jeevanandam, Jaison, additional, Jimenez-Hernandez, Alejandra, additional, Jin, Zhengyu, additional, Kabir, Sumaya F., additional, Kanny, Krishnan, additional, Lakkakula, Jaya, additional, Lizardi-Mendoza, J., additional, Machado, Manuela, additional, Madhujith, T., additional, Maniam, Gaanty Pragas, additional, Manzano, Verónica E., additional, Martínez-López, A.L., additional, Martínez-Robinson, K.G., additional, McClements, David Julian, additional, Miao, Ming, additional, Milivojevic, Milan, additional, Minhajul Islam, Md., additional, Mok Tsze Chung, Aurelie Sarah, additional, Mubarak, Mohammad S., additional, Muhammad, Naveed, additional, Munir, Hira, additional, Murugan, Sesha Subramanian, additional, Nayak, Amit Kumar, additional, Neves, Ana R., additional, Olatunde, Ahmed, additional, Pajic-Lijakovic, Ivana, additional, Pal, Dilipkumar, additional, Papagiannopoulos, Aristeidis, additional, Pintado, Manuela, additional, Popa, Marcel, additional, Qamar, Sarmad Ahmad, additional, Quintela, Telma, additional, Racovita, Stefania, additional, Rafeeq, Hamza, additional, Rahim, Mohd Hasbi Ab., additional, Rahman, Ashiqur, additional, Rahman, Mohammed Mizanur, additional, Raj, Khushboo, additional, Rane, Ajay Vasudeo, additional, Rascón-Chu, A., additional, Rauf, Abdur, additional, Repetto, Evangelina, additional, Rico-García, Enrique, additional, Saha, Supriyo, additional, Sazedul Islam, Md., additional, Shahruzzaman, Md., additional, Silva, Sara, additional, Sousa, Ângela, additional, Sulaiman, Ahmad Ziad, additional, Sultana, Sabrina, additional, Tan, Joash Ban Lee, additional, Tanori-Cordova, J., additional, Teo, Yong Kiat, additional, Tiwari, Himja, additional, torres-Pacheco, Irineo, additional, Tufail, Tabussam, additional, Vasiliu, Silvia, additional, Venkatesan, Jayachandran, additional, Vlassi, Eleni, additional, Wagh, Nilesh Shirish, additional, Wedamulla, N.E., additional, Yadav, Deepti, additional, and Yang, Zhongyu, additional

Published
2022
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8. Oral administration of zein-based nanoparticles reduces glycemia and improves glucose tolerance in rats

Author

Reboredo-Fuentes, C. (Cristian), Gonzalez-Navarro, C.J. (Carlos Javier), Martínez-López, A.L. (Ana L.), and Irache, J.M. (Juan Manuel)

Subjects
Zein, Diabetes, Nanoparticles, Insulin, Hypoglycemic, GLP-1
Abstract

The aim was to evaluate the effect of zein-based nanoparticles on the glucose homeostasis, following oral administration to Wistar rats. For this purpose, bare nanoparticles (NP, with tropism for the upper intestinal regions) and poly(ethylene glycol)-coated nanoparticles (NP-PEG), with the capability to reach the ileum and cecum of animals, were evaluated. Both formulations were spherical in shape, displaying sizes around 200 nm and a negative surface zeta potential. The oral administration of a single dose of these nanoparticles to animals (50 mg/kg) induced a significant decrease of the glycemia, compared control rats and in animals treated with the free protein (p < 0.001). Moreover, these nanoparticles improved the glycemic control against an intraperitoneal glucose tolerance test; particularly NP-PEG. These findings would be due to an increased release of glucagon-like peptide-1 (GLP-1) by L-cells, which are more abundant in distal regions of the intestine. In fact, the GLP-1 blood levels of animals treated with nanoparticles were significantly higher than controls (about 40 % and 60 % for NP and NP-PEG groups, respectively). This higher capability of NP-PEG, with respect to NP, to increase the release of GLP-1 and control glycemia would be related to its ability to reach the distal areas of the small intestine.

Published
2022

10. Preparation and evaluation of PEG-coated zein nanoparticles for oral drug delivery purposes

Author

Reboredo-Fuentes, C. (Cristian), Gonzalez-Navarro, C.J. (Carlos Javier), Martinez-Oharriz, C. (Cristina), Martínez-López, A.L. (Ana L.), and Irache, J.M. (Juan Manuel)

Subjects
Oral delivery, Zein, technology, industry, and agriculture, Nanoparticles, macromolecular substances, PEG, Mucus-permeating
Abstract

The aim was to produce PEG-coated nanoparticles (NP-PEG), with mucus-permeating properties, for oral drug delivery purposes by using simple procedures and regulatory-approved compounds in order to facilitate a po- tential clinical development. For this purpose, zein nanoparticles were prepared by desolvation and, then, coated by incubation with PEG 35,000. The resulting nanocarriers displayed a mean size of about 200 nm and a negative zeta potential. The presence of PEG on the surface of nanoparticles was evidenced by electron microscopy and confirmed by FTIR analysis. Likely, the hydrophobic surface of zein nanoparticles (NP) was significantly reduce by their coating with PEG. This increase of the hydrophilicity of PEG-coated nanoparticles was associated with an important increase of their mobility in pig intestinal mucus. In laboratory animals, NP-PEG (fluorescently labelled with Lumogen® Red 305) displayed a different behavior when compared with bare nanoparticles. After oral administration, NP appeared to be trapped in the mucus mesh, whereas NP-PEG were capable of crossing the protective mucus layer and reach the epithelium. Finally, PEG-coated zein nanoparticles, prepared by a simple and reproducible method without employing reactive reagents, may be adequate carriers for promoting the oral bioavailability of biomacromolecules and other biologically active compounds with low permeability properties

Published
2021

12. Effect of the Sb content and the n− and p−GaSb(100) substrates on the physical and chemical properties of InSb As1- alloys for mid-infrared applications: Analysis of surface, bulk and interface

Author

Casallas-Moreno, Y.L., primary, Ramírez-López, M., additional, Villa-Martínez, G., additional, Martínez-López, A.L., additional, Macias, M., additional, Cruz-Orea, A., additional, González de la Cruz, G., additional, Tomás, S.A., additional, Rodríguez-Fragoso, P., additional, Herrera-Pérez, J.L., additional, and Mendoza-Álvarez, J.G., additional

Published
2021
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