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2. Implication of myddosome complex genetic variants in outcome severity of COVID-19 patients

Author

Martínez-Gómez, Laura E., Martinez-Armenta, Carlos, Medina-Luna, Daniel, Ordoñez-Sánchez, María Luisa, Tusie-Luna, Tere, Ortega-Peña, Silvestre, Herrera-López, Brígida, Suarez-Ahedo, Carlos, Jimenez-Gutierrez, Guadalupe Elizabeth, Hidalgo-Bravo, Alberto, Vázquez-Cárdenas, Paola, Vidal-Vázquez, Rosa P., Ramírez-Hinojosa, Juan P., Martinez Matsumoto, Pilar Miyoko, Vargas-Alarcón, Gilberto, Posadas-Sánchez, Rosalinda, Fragoso, José-Manuel, Martínez-Ruiz, Felipe de J., Zayago-Angeles, Dulce M., Mata-Miranda, Mónica Maribel, Vázquez-Zapién, Gustavo Jesús, Martínez-Cuazitl, Adriana, Andrade-Alvarado, Javier, Granados, Julio, Ramos-Tavera, Luis, Camacho-Rea, María del Carmen, Segura-Kato, Yayoi, Rodríguez-Pérez, José Manuel, Coronado-Zarco, Roberto, Franco-Cendejas, Rafael, López-Jácome, Luis Esau, Magaña, Jonathan J., Vela-Amieva, Marcela, Pineda, Carlos, Martínez-Nava, Gabriela Angélica, and López-Reyes, Alberto

Published
2023
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3. The impact of short-chain fatty acid–producing bacteria of the gut microbiota in hyperuricemia and gout diagnosis

Author

Martínez-Nava, Gabriela A., Méndez-Salazar, Eder O., Vázquez-Mellado, Janitzia, Zamudio-Cuevas, Yessica, Francisco-Balderas, Adriana, Martínez-Flores, Karina, Fernández-Torres, Javier, Lozada-Pérez, Carlos, Guido-Gómora, Dafne L., Martínez-Gómez, Laura E., Jiménez-Gutiérrez, Guadalupe E., Pineda, Carlos, Silveira, Luis H., Sánchez-Chapul, Laura, Sánchez-Sánchez, Roberto, Camacho-Rea, María del Carmen, Martínez-Armenta, Carlos, Burguete-García, Ana I., Orbe-Orihuela, Citlalli, Lagunas-Martínez, Alfredo, Palacios-González, Berenice, and López-Reyes, Alberto

Published
2023
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4. Association of the Transmembrane Serine Protease-2 (TMPRSS2) Polymorphisms with COVID-19

Author

Posadas-Sánchez, Rosalinda, primary, Fragoso, José Manuel, additional, Sánchez-Muñoz, Fausto, additional, Rojas-Velasco, Gustavo, additional, Ramírez-Bello, Julian, additional, López-Reyes, Alberto, additional, Martínez-Gómez, Laura E., additional, Sierra-Fernández, Carlos, additional, Rodríguez-Reyna, Tatiana, additional, Regino-Zamarripa, Nora Elemi, additional, Ramírez-Martínez, Gustavo, additional, Zuñiga-Ramos, Joaquín, additional, and Vargas-Alarcón, Gilberto, additional

Published
2022
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5. The Critical Role of Hypoxia in the Re-Differentiation of Human Articular Chondrocytes

Author

Martinez-Armenta, Carlos, primary, Suarez-Ahedo, Carlos, additional, Olivos-Meza, Anell, additional, Camacho-Rea, María C., additional, Martínez-Gómez, Laura E., additional, Jimenez-Gutierrez, Guadalupe Elizabeth, additional, Martínez-Nava, Gabriela A., additional, Gomez-Quiroz, Luis E., additional, Pineda, Carlos, additional, and López-Reyes, Alberto, additional

Published
2022
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7. ACE and ACE2 Gene Variants Are Associated With Severe Outcomes of COVID-19 in Men

Author

Martínez-Gómez, Laura E., primary, Herrera-López, Brígida, additional, Martinez-Armenta, Carlos, additional, Ortega-Peña, Silvestre, additional, Camacho-Rea, María del Carmen, additional, Suarez-Ahedo, Carlos, additional, Vázquez-Cárdenas, Paola, additional, Vargas-Alarcón, Gilberto, additional, Rojas-Velasco, Gustavo, additional, Fragoso, José Manuel, additional, Vidal-Vázquez, Patricia, additional, Ramírez-Hinojosa, Juan P., additional, Rodríguez-Sánchez, Yunuen, additional, Barrón-Díaz, David, additional, Moreno, Mariana L., additional, Martínez-Ruiz, Felipe de J., additional, Zayago-Angeles, Dulce M., additional, Mata-Miranda, Mónica Maribel, additional, Vázquez-Zapién, Gustavo Jesús, additional, Martínez-Cuazitl, Adriana, additional, Barajas-Galicia, Edith, additional, Bustamante-Silva, Ludwing, additional, Zazueta-Arroyo, Diana, additional, Rodríguez-Pérez, José Manuel, additional, Hernández-González, Olivia, additional, Coronado-Zarco, Roberto, additional, Lucas-Tenorio, Vania, additional, Franco-Cendejas, Rafael, additional, López-Jácome, Luis Esau, additional, Vázquez-Juárez, Rocío Carmen, additional, Magaña, Jonathan J., additional, Cruz-Ramos, Marlid, additional, Granados, Julio, additional, Hernández-Doño, Susana, additional, Delgado-Saldivar, Diego, additional, Ramos-Tavera, Luis, additional, Coronado-Zarco, Irma, additional, Guajardo-Salinas, Gustavo, additional, Muñoz-Valle, José Francisco, additional, Pineda, Carlos, additional, Martínez-Nava, Gabriela Angélica, additional, and López-Reyes, Alberto, additional

Published
2022
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8. Complicidad del fenotipo clínico preexistente con el resultado de muerte en los pacientes de COVID-19

Author

Martínez-Gómez, Laura E, primary, Herrera-López, Brígida, additional, Martinez-Armenta, Carlos, additional, Ortega-Peña, Silvestre, additional, Guido-Gómora, Dafne L, additional, Camacho-Rea, María Carmen, additional, Suárez-Ahedo, Carlos, additional, Vázquez-Cárdenas, Paola, additional, Vargas-Alarcón, Gilberto, additional, Rojas-Velasco, Gustavo, additional, Fragoso, José Manuel, additional, Vidal-Vázquez, Rosa P, additional, Ramírez-Hinojosa, Juan P, additional, Martínez-Ruiz, Felipe de J, additional, Zayago-Ángeles, Dulce M, additional, Mata-Miranda, Mónica Maribel, additional, Vázquez-Zapién, Gustavo Jesús, additional, Martínez-Cuatzitl, Adriana, additional, Barajas-Galicia, Edith, additional, Rodríguez-Pérez, José Manuel, additional, Coronado-Zarco, Roberto, additional, Lucas-Tenorio, Vania, additional, Franco-Cendejas, Rafael, additional, López-Jácome, Luis Esaú, additional, Vázquez-Juárez, Rocío Carmen, additional, Magaña, Jonathan J, additional, Granados, Julio, additional, Rámos-Tavera, Luis, additional, Pineda, Carlos, additional, Martínez-Nava, Gabriela Angélica, additional, and López-Reyes, Alberto, additional

Published
2022
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9. Metabolic Reprogramming in SARS-CoV-2 Infection Impacts the Outcome of COVID-19 Patients.

Author

Martínez-Gómez, Laura E., Ibarra-González, Isabel, Fernández-Lainez, Cynthia, Tusie, Teresa, Moreno-Macías, Hortensia, Martinez-Armenta, Carlos, Jimenez-Gutierrez, Guadalupe Elizabeth, Vázquez-Cárdenas, Paola, Vidal-Vázquez, Patricia, Ramírez-Hinojosa, Juan P., Rodríguez-Zulueta, Ana P., Vargas-Alarcón, Gilberto, Rojas-Velasco, Gustavo, Sánchez-Muñoz, Fausto, Posadas-Sanchez, Rosalinda, Martínez-Ruiz, Felipe de J., Zayago-Angeles, Dulce M., Moreno, Mariana L., Barajas-Galicia, Edith, and Lopez-Cisneros, Gerardo

Subjects
COVID-19, SARS-CoV-2, TANDEM mass spectrometry, TYPE 2 diabetes, CORONAVIRUS diseases, AMINO acids
Abstract

Severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2) infection triggers inflammatory clinical stages that affect the outcome of patients with coronavirus disease 2019 (COVID-19). Disease severity may be associated with a metabolic imbalance related to amino acids, lipids, and energy-generating pathways. The aim of this study was to characterize the profile of amino acids and acylcarnitines in COVID-19 patients. A multicenter, cross-sectional study was carried out. A total of 453 individuals were classified by disease severity. Levels of 11 amino acids, 31 acylcarnitines, and succinylacetone in serum samples were analyzed by electrospray ionization–triple quadrupole tandem mass spectrometry. Different clusters were observed in partial least squares discriminant analysis, with phenylalanine, alanine, citrulline, proline, and succinylacetone providing the major contribution to the variability in each cluster (variable importance in the projection >1.5). In logistic models adjusted by age, sex, type 2 diabetes mellitus, hypertension, and nutritional status, phenylalanine was associated with critical outcomes (odds ratio=5.3 (95% CI 3.16-9.2) in the severe vs. critical model, with an area under the curve of 0.84 (95% CI 0.77-0.90). In conclusion the metabolic imbalance in COVID-19 patients might affect disease progression. This work shows an association of phenylalanine with critical outcomes in COVID-19 patients, highlighting phenylalanine as a potential metabolic biomarker of disease severity. [ABSTRACT FROM AUTHOR]

Published
2022
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